<PAGE>
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13D
(Amendment No. 1)
Under the Securities Exchange Act of 1934
TRANSKARYOTIC THERAPIES, INC.
--------------------------------------------------------------------------------
(Name of Issuer)
Common Shares, $0.01 Par Value
--------------------------------------------------------------------------------
(Title of Class of Securities)
893735-10-0
--------------------------------------------------------------------------------
(CUSIP Number of Class of Securities)
Stephen Distler
E.M. Warburg, Pincus & Co., LLC
466 Lexington Avenue
New York, New York 10017
(212) 878-0600
--------------------------------------------------------------------------------
(Name, Address and Telephone Number of Person
Authorized to Receive Notices and Communications)
Copies to:
Peter H. Jakes, Esq.
Willkie Farr & Gallagher
787 Seventh Avenue
New York, NY 10019-6099
(212) 728-8000
June 16, 2000
--------------------------------------------------------------------------------
(Date of Event which Requires
Filing of this Schedule)
If the filing person has previously filed a statement on Schedule 13G to
report the acquisition which is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-1(b)(3) or (4), check the following: [ ]
<PAGE>
SCHEDULE 13D
------------------- -----------------
CUSIP No. 92829S104 Page 2 of 9 Pages
------------------- -----------------
----------- --------------------------------------------------------------------
1 NAME OF REPORT PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Warburg, Pincus Equity Partners, L.P. I.D. #13-3986317
----------- --------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) [X]
(b) [ ]
----------- --------------------------------------------------------------------
3 SEC USE ONLY
----------- --------------------------------------------------------------------
4 SOURCE OF FUNDS*
WC
----------- --------------------------------------------------------------------
5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT
TO ITEMS 2(d) or 2(e) [ ]
----------- --------------------------------------------------------------------
6 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
--------------------- --------- ------------------------------------------------
7 SOLE VOTING POWER
3,375,000
NUMBER OF --------- ------------------------------------------------
SHARES 8 SHARED VOTING POWER
BENEFICIALLY
OWNED BY
EACH --------- ------------------------------------------------
REPORTING 9 SOLE DISPOSITIVE POWER
PERSON WITH
3,375,000
--------- ------------------------------------------------
10 SHARED DISPOSITIVE POWER
----------- --------------------------------------------------------------------
11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON
3,375,000
----------- --------------------------------------------------------------------
12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
SHARES* [ ]
----------- --------------------------------------------------------------------
13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
13.0%
----------- --------------------------------------------------------------------
14 TYPE OF REPORTING PERSON*
PN
----------- --------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
(INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
<PAGE>
SCHEDULE 13D
------------------- -----------------
CUSIP No. 92829S104 Page 3 of 9 Pages
------------------- -----------------
----------- --------------------------------------------------------------------
1 NAME OF REPORT PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Warburg, Pincus & Co. I.D. #13-6358475
----------- --------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) [X]
(b) [ ]
----------- --------------------------------------------------------------------
3 SEC USE ONLY
----------- --------------------------------------------------------------------
4 SOURCE OF FUNDS*
N/A
----------- --------------------------------------------------------------------
5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT
TO ITEMS 2(d) or 2(e) [ ]
----------- --------------------------------------------------------------------
6 CITIZENSHIP OR PLACE OF ORGANIZATION
New York
--------------------- --------- ------------------------------------------------
7 SOLE VOTING POWER
38,667
NUMBER OF --------- ------------------------------------------------
SHARES 8 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 3,571,619
EACH
REPORTING --------- ------------------------------------------------
PERSON WITH 9 SOLE DISPOSITIVE POWER
38,667
--------- ------------------------------------------------
10 SHARED DISPOSITIVE POWER
3,571,619
----------- --------------------------------------------------------------------
11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON
3,610,286
----------- --------------------------------------------------------------------
12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
SHARES* [ ]
----------- --------------------------------------------------------------------
13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
13.8%
----------- --------------------------------------------------------------------
14 TYPE OF REPORTING PERSON*
PN
----------- --------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
(INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
<PAGE>
SCHEDULE 13D
------------------- -----------------
CUSIP No. 92829S104 Page 4 of 9 Pages
------------------- -----------------
----------- --------------------------------------------------------------------
1 NAME OF REPORT PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
E.M. Warburg, Pincus & Co., LLC I.D. #13-3536050
----------- --------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) [X]
(b) [ ]
----------- --------------------------------------------------------------------
3 SEC USE ONLY
----------- --------------------------------------------------------------------
4 SOURCE OF FUNDS*
N/A
----------- --------------------------------------------------------------------
5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT
TO ITEMS 2(d) or 2(e) [ ]
----------- --------------------------------------------------------------------
6 CITIZENSHIP OR PLACE OF ORGANIZATION
New York
--------------------- --------- ------------------------------------------------
7 SOLE VOTING POWER
0
NUMBER OF --------- ------------------------------------------------
SHARES 8 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 3,610,286
EACH
REPORTING --------- ------------------------------------------------
PERSON WITH 9 SOLE DISPOSITIVE POWER
0
--------- ------------------------------------------------
10 SHARED DISPOSITIVE POWER
3,610,286
---------- ---------------------------------------------------------------------
11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON
---------- --------------------------------------------------------------------
12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
SHARES* [ ]
---------- --------------------------------------------------------------------
13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
13.8%
---------- ---------------------------------------------------------------------
14 TYPE OF REPORTING PERSON*
OO
----------- --------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
(INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
<PAGE>
This Amendment No. 1 (the "Amendment") amends the Schedule 13D filed on
June 16, 2000 (the "Schedule 13D") and is being filed on behalf of Warburg,
Pincus Equity Partners, L.P., a Delaware limited partnership ("WPEP"), Warburg,
Pincus & Co., a New York general partnership ("WP"), and E.M. Warburg, Pincus &
Co., LLC, a New York limited liability company ("EMW" and, together with WPEP
and WP, the "Reporting Entities"). This Amendment relates to the common shares,
par value $0.01, of Transkaryotic Therapies, Inc., a Delaware corporation (the
"Company"). Unless the context otherwise requires, references herein to the
"Common Stock" are to the common shares of Transkaryotic Therapies, par value
$0.01 per share. The holdings of Common Stock of WP and EMW in this Schedule 13D
include certain shares of Common Stock which may be deemed to be beneficially
owned by Warburg, Pincus Netherlands Equity Partners I, C.V. ("WPNEPI"),
Warburg, Pincus Netherlands Equity Partners II, C.V. ("WPNEPII") and Warburg,
Pincus Netherlands Equity Partners III, C.V. ("WPNEPIII" and, together with
WPNEPI, WPNEPII and WPEP, the "Investors"). WP, EMW and the Investors are
referred to herein as the "Group Members."
Unless otherwise indicated herein, each capitalized term used but not
defined herein shall have the meaning assigned to such term in the Schedule 13D.
<PAGE>
This Amendment is being filed as a result of the acquisition of an
additional 1,000 Series A Convertible Preferred Shares of the Company by the
Investors, pursuant to the Purchase Agreement.
Item 3. Source and Amount of Funds or Other Consideration.
Item 3 of the Schedule 13D is hereby amended to read as follows:
"The total amount of funds required by the Investors to purchase the
securities of the Company as described herein was US$100,000,000, and was
furnished from the working capital of the Investors."
Item 5. Interest in Securities of the Issuer.
Item 5 of the Schedule 13D is hereby amended to read as follows:
"(a) The Reporting Entities beneficially own shares of Common Stock of the
Company by virtue of their ownership of Series A Convertible Preferred Shares,
which are convertible into shares of Common Stock. As of June 28, 2000, WP and
EMW each beneficially owned 3,610,286 shares of Common Stock. Also as of this
date, WPEP beneficially owned 3,375,000 shares of Common Stock. Of the shares
beneficially owned by WP and EMW, 196,429 shares represent the aggregate Common
Stock beneficially held by WPNEPI, WPNEPII and WPNEPIII. By
<PAGE>
reason of WP's and EMW's respective relationships with the Investors, under Rule
13d-3 under the Exchange Act, WP and EMW may be deemed to own beneficially all
of the shares of Common Stock which are beneficially owned by these entities.
Assuming full conversion of the corresponding Series A Convertible
Preferred Shares, as of June 28, 2000, the 3,610,286 shares of Common Stock
beneficially held by the Reporting Entities represented approximately 13.8% of
the sum of the outstanding shares of Common Stock (based on the 22,683,306
shares of Common Stock outstanding as of April 21, 2000, as set forth in the
Company's definitive Proxy Statement for its Annual Meeting of Stockholders on
June 15, 2000) together with the 3,571,429 shares of Common Stock issuable upon
conversion of the Series A Preferred Shares held by the Reporting Entities.
Assuming full conversion of the corresponding Series A Convertible Preferred
Shares, as of June 28, 2000, the 3,375,000 shares of Common Stock beneficially
held by WPEP represented approximately 13.0% of the sum of 3,375,000 and the
22,683,306 outstanding shares of Common Stock.
As of June 28, 2000, assuming full exercise of the applicable Shares,
WPNEPI, WPNEPII and WPNEPIII held beneficial ownership of an aggregate of
196,429 shares of Common Stock, which is 0.9% of the sum of 196,429 and
22,683,306.
<PAGE>
(b) WPEP has beneficial ownership over 3,375,000 shares of Common Stock.
WPNEPI, WPNEPII and WPNEPIII have beneficial ownership of an aggregate of
196,429 shares of Common Stock. WPEP, WPNEPI, WPNEPII and WPNEPIII each share
voting power and dispositive power over their holdings of such shares with EMW
and WP.
(c) Except for securities acquired pursuant to the Purchase Agreement,
during the last sixty days there were no transactions effected by the Reporting
Entities or by any of the persons set forth on Schedule I hereto.
(d) Except as set forth in this Item 5, no person other than each
respective record owner referred to herein of securities is known to have the
right to receive or the power to direct the receipt of dividends from, or the
proceeds from the sale of, such securities.
(e) Not applicable."
<PAGE>
SIGNATURES
After reasonable inquiry and to the best of our knowledge and belief, the
undersigned certify that the information set forth in this statement is true,
complete and correct.
Dated: June 29, 2000 WARBURG, PINCUS EQUITY
PARTNERS, L.P.
By: Warburg, Pincus & Co.,
General Partner
By: /s/ Stephen Distler
------------------------------
Stephen Distler
Partner
Dated: June 29, 2000 WARBURG, PINCUS & CO.
By: /s/ Stephen Distler
------------------------------
Stephen Distler
Partner
Dated: June 29, 2000 E.M. WARBURG, PINCUS & CO., LLC
By: /s/ Stephen Distler
------------------------------
Stephen Distler
Member
<PAGE>
SCHEDULE I
----------
Set forth below is the name, position and present principal occupation of
each of the general partners of Warburg, Pincus & Co. ("WP") and members of E.M.
Warburg, Pincus & Co., LLC ("EMW LLC"). The sole general partner of Warburg,
Pincus Equity Partners, L.P. ("WPEP") is WP. WPEP, WP, and EMW LLC are
hereinafter collectively referred to as the "Reporting Entities". Except as
otherwise indicated, the business address of each of such persons is 466
Lexington Avenue, New York, New York 10017, and each of such persons is a
citizen of the United States.
GENERAL PARTNERS OF WP
----------------------
---------------------------- ---------------------------------------------------
PRESENT PRINCIPAL OCCUPATION IN ADDITION
TO POSITION WITH WP, AND POSITIONS
NAME WITH THE REPORTING ENTITIES
---------------------------- ---------------------------------------------------
Joel Ackerman Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Harold Brown Partner of WP; Member and Senior Managing Director
of EMW LLC
---------------------------- ---------------------------------------------------
W. Bowman Cutter Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Cary J. Davis Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Stephen Distler Partner of WP; Member, Managing Director and
Treasurer of EMW LLC
---------------------------- ---------------------------------------------------
Stewart K. P. Gross Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
<PAGE>
---------------------------- ---------------------------------------------------
Patrick T. Hackett Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Jeffrey A. Harris Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
William H. Janeway Partner of WP; Member and Senior Managing Director
of EMW LLC
---------------------------- ---------------------------------------------------
Douglas M. Karp Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Charles R. Kaye Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Henry Kressel Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Joseph P. Landy Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Sidney Lapidus Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Kewsong Lee Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Jonathan S. Leff Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Reuben S. Leibowitz Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
David E. Libowitz Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Nancy Martin Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Edward J. McKinley Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Rodman W. Moorhead III Partner of WP; Member and Senior Managing Director
of EMW LLC
---------------------------- ---------------------------------------------------
Howard H. Newman Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
<PAGE>
---------------------------- ---------------------------------------------------
Gary D. Nusbaum Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Dalip Pathak Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Lionel I. Pincus Managing Partner of WP; Managing Member, Chairman
of the Board and Chief Executive Officer of EMW LLC
---------------------------- ---------------------------------------------------
John D. Santoleri Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Henry Schacht Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Steven G. Schneider Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
John L. Vogelstein Partner of WP; Member and Vice Chairman of EMW LLC
---------------------------- ---------------------------------------------------
Elizabeth H. Weatherman Partner of WP; Member and Managing Director of EMW
LLC
---------------------------- ---------------------------------------------------
Pincus & Co.*
---------------------------- ---------------------------------------------------
NL & Co.**
---------------------------- ---------------------------------------------------
---------------------
* New York limited partnership; primary activity is ownership interest in WP
and EMW LLC.
** New York limited partnership; primary activity is ownership interest in WP.
As of 6/00
<PAGE>
MEMBERS OF EMW LLC
------------------
---------------------------- ---------------------------------------------------
PRESENT PRINCIPAL OCCUPATION IN ADDITION
TO POSITION WITH EMW LLC, AND POSITIONS
NAME WITH THE REPORTING ENTITIES
---------------------------- ---------------------------------------------------
Joel Ackerman Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Frank M. Brochin (1) Member and Managing Director of EMW LLC
---------------------------- ---------------------------------------------------
Harold Brown Member and Senior Managing Director of EMW LLC;
Partner of WP
---------------------------- ---------------------------------------------------
W. Bowman Cutter Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Cary J. Davis Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Stephen Distler Member, Managing Director, and Treasurer of EMW
LLC; Partner of WP
---------------------------- ---------------------------------------------------
Tetsuya Fukagawa (2) Member and Managing Director of EMW LLC
---------------------------- ---------------------------------------------------
Stewart K. P. Gross Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Alf Grunwald (3) Member and Managing Director of EMW LLC
---------------------------- ---------------------------------------------------
Patrick T. Hackett Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Jeffrey A. Harris Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Roberto Italia (4) Member and Managing Director of EMW LLC
---------------------------- ---------------------------------------------------
William H. Janeway Member and Senior Managing Director of EMW LLC;
Partner of WP
---------------------------- ---------------------------------------------------
<PAGE>
---------------------------- ---------------------------------------------------
Douglas M. Karp Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Charles R. Kaye Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Henry Kressel Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Rajiv B. Lall (5) Member and Managing Director of EMW LLC
---------------------------- ---------------------------------------------------
Joseph P. Landy Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Sidney Lapidus Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Kewsong Lee Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Jonathan S. Leff Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Reuben S. Leibowitz Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
David E. Libowitz Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Nicholas J. Lowcock (6) Member and Managing Director of EMW LLC
---------------------------- ---------------------------------------------------
John W. MacIntosh (7) Member and Managing Director of EMW LLC
---------------------------- ---------------------------------------------------
Nancy Martin Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Edward J. McKinley Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
James McNaught-Davis (6) Member and Managing Director of EMW LLC
---------------------------- ---------------------------------------------------
Rodman W. Moorhead III Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Howard H. Newman Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
<PAGE>
---------------------------- ---------------------------------------------------
Gary D. Nusbaum Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Dalip Pathak Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Lionel I. Pincus Managing Member, Chairman of the Board and Chief
Executive of EMW LLC; Managing Partner of WP
---------------------------- ---------------------------------------------------
John D. Santoleri Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Henry Schacht Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Steven G. Schneider Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Dominic H. Shorthouse (6) Member and Managing Director of EMW LLC
---------------------------- ---------------------------------------------------
Melchior Stahl (3) Member and Managing Director of EMW LLC
---------------------------- ---------------------------------------------------
Chang Q. Sun (8) Member and Managing Director of EMW LLC
---------------------------- ---------------------------------------------------
John L. Vogelstein Member and Vice Chairman of EMW LLC; Partner of WP
---------------------------- ---------------------------------------------------
Elizabeth H. Weatherman Member and Managing Director of EMW LLC; Partner of
WP
---------------------------- ---------------------------------------------------
Jeremy S. Young (6) Member and Managing Director of EMW LLC
---------------------------- ---------------------------------------------------
Pincus & Co.*
---------------------------- ---------------------------------------------------
(1) - Citizen of France
(2) - Citizen of Japan
(3) - Citizen of Germany
(4) - Citizen of Italy
(5) - Citizen of India
(6) - Citizen of United Kingdom
(7) - Citizen of Canada
(8) - Citizen of China
<PAGE>
* New York limited partnership; primary activity is ownership interest in WP
and EMW LLC
As of 6/00
