PROCEPT INC
SC 13D/A, 1999-06-01
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13D
                                (Amendment No. 4)

                    Under the Securities Exchange Act of 1934


                                 Procept, Inc.
                                 -------------
                                (Name of Issuer)


                     Common Stock, par value $.01 per share
                     --------------------------------------
                         (Title of Class of Securities)

                                  742 683 10 5
                                  ------------
                                 (CUSIP Number)


                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300
                     --------------------------------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)



                                 March 13, 1999
                                 --------------
             (Date of Event which Requires Filing of this Statement)








<PAGE>

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which  is the  subject  of  this  Statement  because  of  Rule
13d-1(e), 13d-1(f) of 13d-1(g), check the following:
                                                                        [ ]





                                         2

<PAGE>

                                  SCHEDULE 13D
CUSIP No. 742683105                                          Page 3 of 16  Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

    Paramount Capital Asset Management, Inc.
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION
    Delaware
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                        None
  NUMBER OF
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY             6,696,072
EACH REPORTING
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        6,696,072
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON
         6,696,072
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                 [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         49.9%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         CO
- --------------------------------------------------------------------------------

                                       3

<PAGE>

                                  SCHEDULE 13D

CUSIP No. 742683105                                          Page 4 of 16  Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

    Aries Domestic Fund, L.P.
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION
    Delaware
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                        None
  NUMBER OF
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY             2,328,071
EACH REPORTING
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        2,328,071
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON
         2,328,071
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                 [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         19.4%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         PN
- --------------------------------------------------------------------------------

                                        4


<PAGE>

                                  SCHEDULE 13D
CUSIP No. 742683105                                          Page 5 of 16  Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

    The Aries Master Fund, A Cayman Island Exempted Company
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION
    Cayman Islands
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                        None
  NUMBER OF
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY             4,368,000
EACH REPORTING
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        4,368,000
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON
         4,368,000
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                 [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         34.5%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         OO (see Item 2)
- --------------------------------------------------------------------------------

                                        5


<PAGE>
                                  SCHEDULE 13D

CUSIP No. 742683105                                          Page 6 of 16  Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

    Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION
    United States
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                        1,263,122
  NUMBER OF
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY             6,696,072
EACH REPORTING
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        1,263,122
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        6,696,072
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON
         7,959,194
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                 [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         54.7%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         IN
- --------------------------------------------------------------------------------


                                       6


<PAGE>

Item 1. Security and Issuer.
        -------------------

        (a)    Common Stock, $.01 par value ("Shares")

               Procept, Inc. (the "Issuer")
               840 Memorial Drive
               Cambridge, MA 02139
               (617) 491-1100

Item 2. Identity and Background.
        -----------------------

        Names of Persons Filing:

        (a)    This  statement  is filed on behalf of  Paramount  Capital  Asset
               Management, Inc. ("Paramount Capital"), Aries Domestic Fund, L.P.
               ("Aries  Domestic"),  Aries Master Fund, a Cayman Island exempted
               company  ("Aries  Fund") and  Lindsay A.  Rosenwald,  M.D.  ("Dr.
               Rosenwald" and collectively,  "Reporting Parties").  See attached
               Exhibit A which is a copy of their  agreement  in writing to file
               this statement on behalf of each of them.

        (b)    Paramount   Capital's,   Aries  Domestic's  and  Dr.  Rosenwald's
               business address is 787 Seventh Avenue, 48th Floor, New York, New
               York,   10019.  The  business  address  for  Aries  Fund  is  c/o
               MeesPierson  (Cayman)  Limited,  P.O. Box 2003,  British American
               Centre, Phase 3, Dr. Roy's Drive, George Town, Grand Cayman.

        (c)    Dr. Rosenwald is an investment banker,  venture capitalist,  fund
               manager  and  sole  shareholder  of  Paramount  Capital,   /1/  a
               Subchapter S  corporation  incorporated  in  Delaware.  Paramount
               Capital is the General Partner of Aries  Domestic,  /2/ a limited
               partnership  incorporated in Delaware.  Paramount  Capital is the
               Investment  Manager to Aries Fund, /3/ a Cayman Islands  exempted
               company.

        (d)    Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries Fund
               and  their  respective  officers,  directors,  general  partners,
               investment managers,  or trustees have not, during the five years
               prior to the date hereof, been convicted in a criminal proceeding
               (excluding traffic violations or similar misdemeanors).

        (e)    Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries Fund
               and  their  respective  officers,  directors,  general  partners,
               investment  managers,  or trustees have not been, during the five
               years prior to the date hereof,  parties to a civil proceeding of
               a judicial or administrative body of competent jurisdiction, as a
               result of which such  person  was or is  subject  to a  judgment,
               decree  or  final  order  enjoining  future   violations  of,  or
               prohibiting or mandating  activities subject to, Federal or State
               securities  laws or finding any  violation  with  respect to such
               laws.

        (f)    Dr. Rosenwald is a citizen of the United States.

Item 3. Source and Amount of Funds or Other Consideration.
        -------------------------------------------------

               Since the date of Amendment  No. 3 to the  Original  Statement on
               Schedule  13-D  ("Amendment  No. 3"),  filed on August 10,  1998,
               Aries Domestic used its general funds to purchase an aggregate of
               5,200  Shares  in the open  market  and the  Aries  Fund used its
               general  funds to purchase an aggregate  of 14,800  Shares in the
               open market.
- --------
               /1/    Please see  attached  Exhibit B indicating  the  executive
                      officers and directors of Paramount  Capital and providing
                      information  called for by Items 2-6 of this  statement as
                      to  said  officers  and  directors.  Exhibit  B is  herein
                      incorporated by reference.

               /2/    Please  see  attached  Exhibit C  indicating  the  general
                      partner  of  Aries  Domestic  and  the  general  partner's
                      executive officers and directors and providing information
                      called  for by  Items  2-6 of  this  statement  as to said
                      general  partners,  officers and  directors.  Exhibit C is
                      herein incorporated by reference.

               /3/    Please see attached  Exhibit D indicating  the  investment
                      manager  of the Aries  Fund and the  investment  manager's
                      executive officers and directors and providing information
                      called  for by  Items  2-6 of  this  statement  as to said
                      investment  manager and officers and directors.  Exhibit D
                      is herein incorporated by reference.



                                       7

<PAGE>

               In connection with a merger (the "Merger") between the Issuer and
               Pacific Pharmaceuticals,  Inc. ("Pacific"), which closed on March
               13, 1999, each of the Reporting Parties  exchanged  securities of
               Pacific for securities of the Issuer as follows:

               Aries Domestic:
               --------------

               (a) 4,299 shares of Series A Preferred Stock of Pacific converted
               into 135,872  shares of common stock of the Issuer with  attached
               contractual   rights  (the  "Article  VI  Common   Stock")  at  a
               conversion rate equal to 31.60543;

               (b) 49,240 shares of Article VI Common Stock were issued pursuant
               to certain  contractual  anti-dilutive  rights of the  Article VI
               Common Stock in (a) above that were triggered by the Merger;

               (c) a Unit Purchase Option to purchase (1) 430 shares of Series A
               Preferred Stock of Pacific and (2) Class A Warrants of Pacific to
               purchase  42,900  shares of common stock of Pacific (the "Pacific
               Common  Stock")  was  exchanged  for a Unit  Purchase  Option  to
               purchase  (x) 13,590  shares of  Article VI Common  Stock and (y)
               Class C Warrants  to  purchase  4,661  shares of  Procept  Common
               Stock;

               (d) warrants to purchase  4,925 shares of Article VI Common Stock
               were issued pursuant to certain contractual  anti-dilutive rights
               of the  Article  VI  Common  Stock  in  (c)(x)  above  that  were
               triggered by the Merger;

               (e) warrants to purchase  45,000  shares of Pacific  Common Stock
               were  exchanged for Class C Warrants to purchase  4,889 shares of
               Procept Common Stock;

               (f) 305,641  shares of Pacific  Common Stock were  exchanged  for
               33,208 shares of Procept Common Stock;

               (g) a note owed by Binary  Therapeutics,  Inc., a  subsidiary  of
               Pacific,  to Aries  Domestic was  exchanged  for 19,275 shares of
               Article VI Common Stock ;

               (h)  6,985   shares  of  Article  VI  Common   Stock   issued  as
               anti-dilution protection to the Article VI Common Stock issued in
               (g) above;

               (i) Class A Warrants  of Pacific to  purchase  429,900  shares of
               Pacific  Common  Stock were  exchanged  for Class C  Warrants  to
               purchase 46,709 shares of Article VI Common Stock;

               (j) 200,000  shares of Pacific  Common Stock were  exchanged  for
               21,730 shares of Procept Common Stock;

               (k) Class A Warrants to purchase 250,000 shares of Pacific Common
               Stock were exchanged for 27,163 shares of Procept Common Stock;

               (l) Unit Purchase Option to purchase (1) 31,250 shares of Pacific
               Common  Stock and (2) Class A Warrants  of  Pacific  to  purchase
               25,000  shares of Pacific  Common  Stock were  exchanged  for (x)
               3,395  shares of Article VI Common Stock and (y) Class C Warrants
               to purchase 2,716 shares of Procept Common Stock; and

               Aries Fund:
               ----------

               (a) 8,340 shares of Series A Preferred Stock of Pacific converted
               into 263,589 shares of Article VI Common Stock;

               (b) 95,525 shares of Article VI Common Stock were issued pursuant
               to certain  contractual  anti-dilutive  rights of the  Article VI
               Common Stock in (k) above that were triggered by the Merger;

               (c) Unit  Purchase  Option to purchase (1) 834 shares of Series A
               Preferred Stock of Pacific and (2) Class A Warrants of Pacific to
               purchase 83,400 shares of Pacific Common Stock were exchanged for
               a Unit  Purchase  Option to purchase (x) 26,359 shares of Article
               VI Common Stock and (y) Class C Warrants to purchase 9,061 shares
               of Procept Common Stock;



                                       8

<PAGE>

               (d) warrants to purchase  9,552 shares of Article VI Common Stock
               were issued pursuant to certain contractual  anti-dilutive rights
               of the  Article  VI  Common  Stock  in  (c)(x)  above  that  were
               triggered by the Merger;

               (e) warrants to purchase  105,000  shares of Pacific Common Stock
               were exchanged for Class C Warrants to purchase  11,408 shares of
               Procept Common Stock;

               (f) 305,641  shares of Pacific  Common Stock were  exchanged  for
               33,208 shares of Procept Common Stock;

               (g) a note owed by Binary  Therapeutics,  Inc., a  subsidiary  of
               Pacific,  to Aries  Domestic was  exchanged  for 19,275 shares of
               Article VI Common Stock ;

               (h)  6,985   shares  of  Article  VI  Common   Stock   issued  as
               anti-dilution protection to the Article VI Common Stock issued in
               (g) above;

               (i) Class A Warrants  of Pacific to  purchase  834,000  shares of
               Pacific  Common  Stock were  exchanged  for Class C  Warrants  to
               purchase 90,614 shares of Article VI Common Stock;

               (j) 200,000  shares of Pacific  Common Stock were  exchanged  for
               21,730 shares of Procept Common Stock;

               (k) Class A Warrants to purchase 250,000 shares of Pacific Common
               Stock were  exchanged for 27,163 shares of Procept  Common Stock;
               and

               (l) Unit Purchase Option to purchase (1) 31,250 shares of Pacific
               Common  Stock and (2) Class A Warrants  of  Pacific  to  purchase
               25,000  shares of Pacific  Common  Stock were  exchanged  for (x)
               3,395  shares of Article VI Common Stock and (y) Class C Warrants
               to purchase 2,716 shares of Procept Common Stock.

               Dr. Rosenwald:
               -------------

               (a) a note owed by Binary  Therapeutics,  Inc., a  subsidiary  of
               Pacific,  to Dr.  Rosenwald  was  exchanged  for 49,824 shares of
               Article VI Common Stock;

               (b)  18,056   shares  of  Article  VI  Common   Stock  issued  as
               anti-dilution protection to the Article VI Common Stock issued in
               (d) above;

               (c) 323,796  shares of Pacific  Common Stock were  exchanged  for
               31,180 shares of Procept Common Stock;

               (d) a Unit  Purchase  Option to purchase  (1)  192,197  shares of
               Pacific  Common  Stock and (2) Class A  Warrants  of  Pacific  to
               purchase 240,214 shares of Pacific Common Stock was exchanged for
               a Unit  Purchase  Option to purchase (x) 20,882 shares of Article
               VI Common  Stock  and (y) Class C  Warrants  to  purchase  26,099
               shares of Procept Common Stock;

               (e) a Unit Purchase Option to purchase (1) 5,701 shares of Series
               A Preferred  Stock of Pacific and (2) Class A Warrants of Pacific
               to purchase  570,064 shares of Pacific Common Stock was exchanged
               for a Unit  Purchase  Option to purchase  (x)  180,183  shares of
               Article  VI Common  Stock and (y) Class C  Warrants  to  purchase
               61,937 shares of Procept Common Stock;

               (f) 65,298  shares of  Article  pursuant  to certain  contractual
               anti-dilutive  rights of the Article VI Common Stock in paragraph
               (e)(x) above that were triggered by the Merger;

               (g) a Unit Purchase Option to purchase (1) 1,999 shares of Series
               A Preferred  Stock of Pacific and (2) Class A Warrants of Pacific
               to purchase  199,887 shares of Pacific Common Stock was exchanged
               for a Unit  Purchase  Option to  purchase  (x)  63,179  shares of
               Article  VI Common  Stock and (y) Class C  Warrants  to  purchase
               21,718 shares of Procept Common Stock; and

               (h) 22,896  shares of  Article  pursuant  to certain  contractual
               anti-dilutive  rights of the Article VI Common Stock in paragraph
               (g)(x) above that were triggered by the Merger.



                                       9

<PAGE>

               Further,   in  connection  with  a  contractual  reset  provision
               contained  in the Article VI Common  Stock held by the  Reporting
               Parties, on April 9, 1999, Aries Domestic was issued an aggregate
               of 649,514  additional  shares of Article VI Common Stock,  Aries
               Fund was issued an aggregate of  1,233,722  additional  shares of
               Article VI Common Stock and Dr.
               Rosenwald was issued an aggregate of 331,058.

               (i)  10,865  shares  of  common  stock  of the  Issuer  owned  by
               Paramount Catital Investments, LLC, of which Dr. Rosenwald is the
               Chairman and sole stockholder.

Item 4. Purpose of Transaction.
        ----------------------

               The  Reporting  Parties  acquired  shares of Common  Stock of the
               Issuer as an investment in the Issuer.

               Although the Reporting Parties have not formulated any definitive
               plans, they may from time to time acquire,  or dispose of, Common
               Stock and/or other securities of the Issuer if and when they deem
               it  appropriate.   The  Reporting  Parties  may  formulate  other
               purposes,  plans or proposals  relating to any of such securities
               of the Issuer to the extent  deemed  advisable in light of market
               conditions, investment policies and other factors.

               Except as indicated in this Schedule  13D, the Reporting  Parties
               currently  have no plans or  proposals  that  relate  to or would
               result  in any of the  matters  described  in  subparagraphs  (a)
               through (j) of Item 4 of Schedule 13D.

Item 5. Interest in Securities of the Issuer.
        ------------------------------------

               (a)    As  of  the  date  of  this  filing,  Dr.  Rosenwald  both
                      personally  and through  acquisition  of the shares by the
                      Aries  Fund  and  Aries  Domestic,  beneficially  owned an
                      aggregate  of  7,959,194,  Shares or 54.7% of the Issuer's
                      securi  ties  and  Paramount  Capital  beneficially  owned
                      6,696,072  Shares  or  49.9% of the  Issuer's  securities.
                      Aries  Domestic and the Aries Fund  beneficially  owned as
                      follows:

                                                          Amount Owned
                                                          ------------
                      Aries Domestic                      2,323,071 Shares
                      Aries Fund                          4,368,000 Shares

               (b)    Dr.  Rosenwald  and  Paramount  Capital share the power to
                      vote or to direct  the vote,  to  dispose or to direct the
                      disposition  of  those  shares  owned  by  each  of  Aries
                      Domestic and Aries Fund.

               (c)    Other  than as set  forth in Item 3 above,  the  Reporting
                      Parties have not engaged in any transactions in the Common
                      Stock of the Issuer during the past 60 days.

               (d) & (e)     Not applicable.

Item 6. Contracts, Arrangements, Understandings or Relationships
        with respect to Securities of the Issuer
        ---------------------------------------------------------

               Paramount Capital is the Investment Manager of the Aries Fund and
               the General  Partner of Aries Domestic and in such capacities has
               the authority to make certain  investment  decisions on behalf of
               such entities,  including decisions relating to the securities of
               the Issuer. In connection with its investment  management duties,
               Paramount   Capital   receives   certain   management   fees  and
               performance allocations from the Aries Fund and Aries Domestic.

               Dr.  Rosenwald is the Chairman and sole  shareholder of Paramount
               Capital.  Mr.  Michael  S.  Weiss,  formerly  a  Senior  Managing
               Director of the Placement  Agent (as defined  below),  joined the
               Board of Directors of the Issuer in  connection  with the initial
               investment by Aries  Domestic and the  predecessor in interest to
               the Aries Fund,  the Aries Trust,  a Cayman  Island trust in June
               1997 and receives compensation for such services.

               Pursuant to Article 6 of the Subscription  Agreement  executed by
               the  Issuer  and each  investor  in the  Private  Placement,  the
               Reporting  Parties are  entitled to the  contractual  rights (the
               "Article VI Rights")  attached to the Article VI Common  Stock as
               set forth in Exhibit O to Amendment No. 2.



                                       10

<PAGE>

               Paramount  Capital,  Inc., (the "Placement Agent") an NASD member
               broker  dealer and an affiliate  of Aries  Domestic and the Aries
               Fund has acted as Placement Agent for the Issuer and has received
               certain fees for such services including warrants (the "Placement
               Warrants")  to  purchase  shares of Common  Stock  with  attached
               contractual  rights.  On  June  30,  1997,  the  Issuer  and  the
               Placement Agent entered into a twenty-four  (24) month engagement
               agreement,  pursuant to which the Placement  Agent is entitled to
               receive a cash retainer and standard  success fees in addition to
               warrants (the "Advisory  Warrants") to purchase  shares of Common
               Stock with attached contractual rights.

               Except  as  indicated  in this  13D  and  exhibits,  there  is no
               contract, arrangement,  understanding or relationship between the
               Reporting  Parties  and any other  person,  with  respect  to any
               securities of the Issuer.


Item 7. Material to be Filed as Exhibits:
        --------------------------------

Exhibit A -    Copy of an Agreement  between Dr. Rosenwald,  Paramount  Capital,
               Aries  Domestic and Aries Fund to file this Statement on Schedule
               13D on behalf of each of them.

Exhibit B -    List of executive officers and directors of Paramount Capital and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.

Exhibit C -    List of executive  officers and  directors of Aries  Domestic and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.

Exhibit D -    List of  executive  officers  and  directors  of  Aries  Fund and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.



                                       11

<PAGE>

                                   SIGNATURES
                                   ----------


               After  reasonable  inquiry  and to the best of my  knowledge  and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.

                                     PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:       May 3, 1999
             New York, NY          By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                     ARIES DOMESTIC FUND, L.P.
                                     By Paramount Capital Asset Management, Inc.
                                        General Partner

Dated:       May 3, 1999
             New York, NY          By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                     THE ARIES FUND
                                     By Paramount Capital Asset Management, Inc.
                                        Investment Manager

Dated:       May 3, 1999
             New York, NY          By /s/ Lindsay A. Rosenwald, M.D.
                                   ---------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                        Chairman


Dated:       May 3, 1999
             New York, NY          By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                      Lindsay A. Rosenwald, M.D.


                                       12

<PAGE>

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13D



                  The undersigned hereby agrees to jointly prepare and file with
regulatory  authorities  a  Schedule  13D  and  any  future  amendments  thereto
reporting  each of the  undersigned's  ownership of securities of Endorex Corp.,
and hereby affirm that such Schedule 13D is being filed on behalf of each of the
undersigned.


                                     PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:       May 3, 1999
             New York, NY          By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                     ARIES DOMESTIC FUND, L.P.
                                     By Paramount Capital Asset Management, Inc.
                                        General Partner

Dated:       May 3, 1999
             New York, NY          By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                     THE ARIES FUND
                                     By Paramount Capital Asset Management, Inc.
                                        Investment Manager

Dated:       May 3, 1999
             New York, NY          By /s/ Lindsay A. Rosenwald, M.D.
                                   ---------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                        Chairman


Dated:       May 3, 1999
             New York, NY          By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                      Lindsay A. Rosenwald, M.D.



                                       13

<PAGE>

                                    EXHIBIT B

        The name and principal occupation or employment,  which in each instance
is with Paramount Capital Asset Management,  Inc. ("Paramount  Capital") located
at 787 Seventh Avenue,  48th Floor, New York, New York, 10019, of each executive
officer and director of Paramount Capital is as follows:

<TABLE>
<CAPTION>

                                                                    PRINCIPAL OCCUPATION
        NAME                                                        OR EMPLOYMENT
        ----                                                        -------------
<S>                                                <C>

Lindsay A. Rosenwald, M.D.                         Chairman of the Board of Paramount Capital Asset Management, Inc.,
                                                   Paramount Capital Investments, LLC and Paramount Capital, Inc.

Mark C. Rogers, M.D.                               President of Paramount Capital Asset Management, Inc., Paramount Capital
                                                   Investments, LLC and Paramount Capital, Inc.

Peter Morgan Kash                                  Director of Paramount Capital Asset Management, Inc., Senior Managing
                                                   Director, Paramount Capital, Inc.

Dr. Yuichi Iwaki                                   Director of Paramount Capital Asset Management, Inc., Professor, Univer
                                                   sity of Southern California School of Medicine

</TABLE>

Item 2.

        During  the  five  years  prior to the date  hereof,  none of the  above
persons  (to the best of  Paramount  Capital's  knowledge)  was  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

        Please refer to Items 3-6 herein reporting the beneficial ownership.



                                       14

<PAGE>

                                    EXHIBIT C

        The name and principal occupation or employment, which is located at 787
Seventh Avenue, 48th Floor, New York, New York, 10019, of the General Partner of
Aries Domestic is as follows:

<TABLE>
<CAPTION>


                                                                    PRINCIPAL OCCUPATION
        NAME                                                        OR EMPLOYMENT
        ----                                                        -------------
<S>                                                      <C>
Paramount Capital Asset Management, Inc.                  General Partner; Investment Manager

</TABLE>

        Exhibit B is hereby incorporated by reference.

Item 2.

        During the five years prior to the date hereof, the above person (to the
best of  Aries  Domestic's  knowledge)  has not  been  convicted  in a  criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a  civil  proceeding  of a  judicial  or  administrative  body  of  competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

        Please refer to Items 3-6 herein reporting the beneficial ownership.


                                       15




<PAGE>

                                    EXHIBIT D

        The name and principal occupation or employment,  which in each instance
is with The Aries Master Fund ("Aries Fund") located at 787 Seventh Avenue, 48th
Floor,  New York, New York,  10019,  of each  executive  officer and director of
Aries Trust is as follows:

                                                            PRINCIPAL OCCUPATION
        NAME                                                OR EMPLOYMENT
        ----                                                -------------

Paramount Capital Asset Management, Inc.                 Investment Manager

MeesPierson (Cayman) Management Limited                  Administrator

        Exhibit B is hereby incorporated by reference.

Item 2.

        During the five  years  prior to the date  hereof,  neither of the above
persons  (to the  best of Aries  Fund's  knowledge)  have  been  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

        Please refer to Items 3-6 herein reporting the beneficial ownership.



                                       16




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