EXPRESS SCRIPTS INC
S-8, 1999-06-09
SPECIALTY OUTPATIENT FACILITIES, NEC
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      As Filed with the Securities and Exchange Commission on June 9, 1999
                                                    Registration No. 333-______
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM S-8
                             REGISTRATION STATEMENT
                                    Under the
                             SECURITIES ACT OF 1933

                              EXPRESS SCRIPTS, INC.
             (Exact name of Registrant as specified in its charter)

              DELAWARE                                      43-1420563
   (State or Other Jurisdiction of                       (I.R.S. Employer
   Incorporation or Organization)                        Identification No.)

                              13900 Riverport Drive
                        Maryland Heights, Missouri 63043
                                 (314) 770-1666
                   (Address, including zip code, and telephone
                         number, including area code, of
                    Registrant's principal executive offices)

                   AMENDED AND RESTATED EXPRESS SCRIPTS, INC.
                       1994 STOCK OPTION PLAN, AS AMENDED
                            (Full Title of the Plan)

                            Thomas M. Boudreau, Esq.
     Senior Vice President of Administration, General Counsel and Secretary
                              Express Scripts, Inc.
                              13900 Riverport Drive
                        Maryland Heights, Missouri 63043
                                 (314) 770-1666
            (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)


                           --------------------------

<TABLE>
<CAPTION>

                                           CALCULATION OF REGISTRATION FEE
- ----------------------------------------------------------------------------------------------------------------
                                                     Proposed Maximum     Proposed Maximum     Amount of
   Title of Securities            Amount to be       Offering Price       Aggregate            Registration
    to be Registered               Registered        Per Share(1)         Offering Price(1)    Fee
<S>                           <C>                         <C>                <C>                <C>
Class A Common  Stock,
par value  $0.01 per share
and the related options to
acquire such Common Stock     1,500,000 shares and        $68.4375           $102,656,250       $28,538.44
                                  options (2)
- ---------------------------------------------------------------------------------------------------------------
<FN>


(1)  Computed  pursuant to Rule 457(c) and Rule 457(h) solely for the purpose of
     determining  the   registration   fee.   Proposed  maximum  offering  price
     represents  the  average of the high and low  prices  for the  Registrant's
     Common Stock reported on the Nasdaq National Market on June 4, 1999.
(2)  Includes such additional shares of Class A common Stock as may be issuable
     pursuant to antidilution provisions of the Plan.
</FN>
</TABLE>

     II-26 This Registration  Statement registers  additional  securities of the
same class as other securities for which a registration  statement filed on this
form relating to the same stock option plan is effective. Consequently, pursuant
to General Instruction E of Form S-8, the contents of the Registration Statement
on Form S-8 filed by Express  Scripts,  Inc. (the "Company") with respect to the
Express Scripts,  Inc. Amended and Restated 1994 Stock Option Plan (the "Plan"),
on March 27, 1998,  Registration  No.  333-48767,  are incorporated by reference
into this Registration Statement.

Item 5.      Interest of Named Experts and Counsel

     Thomas M. Boudreau,  Esq., whose opinion is contained in Exhibit 5.1, owned
as of May 31, 1999, options to purchase 118,500 shares of Class A Common Stock.

Item 8.      Exhibits

     See Exhibit Index.


                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the undersigned
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this registration
statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of Maryland Heights, State of Missouri on May 26, 1999.

                                    EXPRESS SCRIPTS, INC.


                                    By: /s/ Barrett A. Toan
                                    Barrett A. Toan
                                    President and Chief Executive Officer

                                POWER OF ATTORNEY

     Each person whose signature  appears below hereby  constitutes and appoints
Barrett A. Toan,  George Paz and Thomas M.  Boudreau and each of them (with full
power to each of them to act alone) his or her true and lawful attorneys-in-fact
and  agents,  for him or her and on his or her  behalf  and is his or her  name,
place  and  stead,  in any and all  capacities,  to sign any and all  amendments
(including  post-effective  amendments) to this Registration  Statement,  and to
file the same,  with exhibits and any and all other documents filed with respect
thereto,  with the Securities and Exchange Commission (or any other governmental
or regulatory authority),  granting unto said attorneys,  and each of them, full
power and authority to do and to perform each and every act and thing  requisite
and  necessary to be done in and about the premises in order to  effectuate  the
same as fully to all  intents  and  purposes  as he or she  might or could do if
personally  present,  hereby ratifying and confirming all that said attorneys in
fact and agents,  or any of them,  may lawfully do or cause to be done by virtue
hereof.

     Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
Registration  Statement  has been signed below by the  following  persons in the
capacities and on the dates indicated.

Signatures                Title                                      Date


/s/ Barrett A. Toan       President, Chief Executive Officer       May 26, 1999
Barrett A. Toan           and Director

/s/ George Paz            Senior Vice President and Chief          May 26, 1999
George Paz                Financial Officer
                          (Principal Financial Officer)

/s/ Joseph W. Plum        Vice President and                       June 2, 1999
Joseph W. Plum            Chief Accounting Officer
                          (Principal Accounting Officer)

/s/ Howard I. Atkins      Director                                 May 26, 1999
Howard I. Atkins

/s/ Judith E. Campbell    Director                                 May 26, 1999
Judith E. Campbell

/s/ Richard M. Kernan, Jr.Director                                 May 26, 1999
Richard M. Kernan, Jr.

                          Director                                 ______, 1999
Richard A. Norling

/s/ Frederick J. Sievert  Director                                 May 26, 1999
Frederick J. Sievert

/s/ Stephen N. Steinig    Director                                 May 26, 1999
Stephen N. Steinig

                          Director                                 ______, 1999
Seymour Sternberg

/s/ Howard L. Waltman     Director                                 May 26, 1999
Howard L. Waltman

/s/ Norman Zachary        Director                                 May 26, 1999
Norman Zachary


                                  EXHIBIT INDEX

Exhibit
Number             Description of Exhibits

4.1        Express Scripts, Inc. Amended and Restated 1994 Stock Option Plan,
               as amended

5.1        Opinion of Thomas M. Boudreau, Esq., Senior Vice President of
               Administration, General Counsel and Secretary of the Registrant

23.1       Consent of PricewaterhouseCoopers LLP

23.2       Consent of Ernst & Young LLP - Minneapolis, Minnesota

23.3       Consent of Ernst & Young LLP - Pittsburgh, Pennsylvania

23.4       Consent of Thomas M. Boudreau, Esq. (included in Exhibit 5.1)

24.1       Power of Attorney (included in Signature Page).



                                                                    Exhibit 4.1

                              EXPRESS SCRIPTS, INC.
                   AMENDED AND RESTATED 1994 STOCK OPTION PLAN


1.       Purposes; Definitions

         The  purposes of the Plan are to further the  growth,  development  and
financial  success of the Company by providing  incentives to those officers and
other key  employees  who have the  capacity  for  contributing  in  substantial
measure  toward the growth and  profitability  of the  Company and to assist the
Company in  attracting  and  retaining  employees  with the ability to make such
contributions.

         To  accomplish  such  purposes,  the Plan provides that the Company may
grant Incentive Stock Options and Nonqualified Stock Options.

         Whenever the following  terms are used in the Plan, they shall have the
meaning specified below unless the context clearly indicates to the contrary.

         "Board" shall mean the Board of Directors of the Company.

         "Cause"  shall mean the  willful  failure by an Employee to perform his
duties with the  Company,  a Parent or a Subsidiary  or the willful  engaging in
conduct  which  is  injurious  to the  Company,  a  Parent  or  any  Subsidiary,
monetarily or otherwise,  as determined by the Committee in its sole discretion,
provided that, if the Employee has entered into an employment agreement with the
Company, the Committee, in its sole discretion,  may determine to substitute the
definition set forth in such agreement.

         "Change in Control" shall mean the following:

                  (i) the first date on which both of the  following  conditions
         shall  exist:  (A) New York Life  Insurance  Company  ("New York Life")
         shall have ceased to be a Parent,  and (B) a "person"  (as such term is
         used in Section  13(d) and 14(d) of the Exchange  Act),  other than the
         Company or a Related  Entity is the  "beneficial  owner" (as defined in
         Rule  13d-3  under  the  Exchange  Act),  directly  or  indirectly,  of
         securities of the Company  representing  fifty percent (50%) or more of
         the  combined  voting  power  for  the  election  of  directors  of the
         Company's then outstanding securities;

                  (ii) the shareholders of the Company approve a plan of
         complete liquidation of the Company; or

                  (iii) the shareholders of the Company approve an agreement for
         the sale or disposition by the Company of all or  substantially  all of
         the Company's assets or any transaction having a similar effect.

         "Change in Control Date" shall mean, in the case of a Change in Control
defined in clause (i) or (ii) of the definition  thereof,  the date on which the
event occurs,  and in the case of a Change in Control defined in clause (iii) of
the definition thereof, the date on which the transaction closes.

         "Change  in  Control   Price"  shall  mean,  in  a  Change  in  Control
transaction in connection  with which New York Life receives  consideration  for
the  transfer or  cancellation  of its voting  securities,  the per share amount
received  by New York  Life;  and in the case of any  other  Change  in  Control
transaction,  the greater of the highest Fair Market Value or the highest  price
per share paid in a bona fide  transaction  related to such Change in Control at
any time during the 60 days immediately preceding the Change in Control Date.

         "Code"  shall mean the Internal  Revenue Code of 1986,  as amended from
time to time.

         "Committee"  shall  mean  the  Compensation  Committee  of  the  Board,
appointed as provided in Section 6.1.

         "Company" shall mean Express Scripts, Inc., a Delaware corporation, and
any successor corporation.

         "Comparable  Employment"  shall mean  employment  with the  Company any
successor to the Company's  business  following a Change in Control  pursuant to
which:

                  (i)  the  responsibilities  and  duties  of the  Employee  are
         substantially the same as before the Change of Control (such changes as
         are a  necessary  consequence  of the fact that the  securities  of the
         Company are no longer publicly traded if the Company's securities cease
         to be publicly  traded as a consequence  of the Change of Control shall
         not be  considered  a change in  responsibilities  or duties),  and the
         other  terms and  conditions  of  employment  following  the  Change in
         Control  do not  impose on the  Employee  obligations  materially  more
         burdensome  than those to which the Employee  was subject  prior to the
         Change in Control;

                  (ii) the aggregate  compensation  (including salary, bonus and
         other  benefit  plans,  including  option  plans) of such  Employee  is
         substantially   economically   equivalent   to  or  greater  than  such
         Employee's  aggregate  compensation  immediately prior to the Change in
         Control  Date. In making such  determination  there shall be taken into
         account    all    contingent    or   unvested    compensation,    under
         performance-based  compensation  plans or otherwise,  with  appropriate
         adjustment   for  rights  of   forfeiture,   vesting  rules  and  other
         contingencies to payment; and

                  (iii)  the  Employee  is not  required  to  relocate  from the
         metropolitan  area of his or her  residence  immediately  preceding the
         Change in Control  (A) unless the  Company or such  successor  pays the
         cost of such  relocation  (including  any  loss and  expenses  that the
         employee may incur upon the sale of his or her  residence),  (B) if the
         relocation  is to an area with a higher cost of living than the area of
         the Employee's  residence  prior to such  relocation,  such  Employee's
         compensation is equitably adjusted to account for such difference,  (C)
         unless the Employee is employed under a written  contract for a term of
         not less than three (3)  years,  and (D) is  required  to make only one
         such move during the first three years of the written contract.

         "Effective Date" shall have the meaning set forth in Section 7.1.

         "Employee"  shall mean any employee  (including any officer  whether or
not a director) of the Company, or of any corporation which is then a Subsidiary
that has been designated by the Board to participate in the Plan.

         "Early  Retirement"  shall mean  retirement  by an Employee from active
employment  with the Company,  a Parent or any  Subsidiary  (i) with the express
consent for purposes of the Plan of the Committee or such officer of the Company
as the Committee may designate  from time to time, or (ii) pursuant to the early
retirement  provisions of a pension plan maintained by the Company,  a Parent or
any Subsidiary.

     "Exchange Act" shall mean the Securities Exchange Act of 1934, as amended.

     "Fair Market  Value" per Share as of a particular  date shall mean,  unless
otherwise determined by the Committee:

                  (i) the closing sales price per Share on a national securities
         exchange  for the  last  preceding  date on which  there  was a sale of
         Shares on such exchange;

                  (ii) if  clause  (i) does not apply  and the  Shares  are then
         quoted on the National  Association  of  Securities  Dealers  Automated
         Quotation  system (known as  "NASDAQ"),  the closing price per Share as
         reported on such system for the last preceding date on which a sale was
         reported;

                  (iii) if clause  (i) or (ii) does not apply and the Shares are
         then traded on an  over-the-counter  market, the average of the closing
         bid and asked prices for the Shares in such over-the-counter market for
         the last preceding date on which such bid and asked prices were quoted;
         or

                  (iv)  if  the  Shares  are  not  then  listed  on  a  national
         securities exchange or traded in an over-the-counter market, such value
         as the Committee in its discretion may determine.

         "Incentive  Stock  Option"  shall  mean an  Option  intended  to be and
designated as an "incentive  stock option"  within the meaning of Section 422 of
the Code.

         "Nonqualified  Stock  Option"  shall  mean  an  Option  that  is not an
Incentive Stock Option.

         "Normal  Retirement"  shall mean  retirement by an Employee from active
employment  with  the  Company,  a  Parent  or any  Subsidiary  (i) on or  after
attainment of age  sixty-five  (65),  or (ii) pursuant to the normal  retirement
provisions  of a  pension  plan  maintained  by the  Company,  a  Parent  or any
Subsidiary.

         "Option" shall mean an option to purchase Shares (including  Restricted
Shares, if the Committee so determines) granted pursuant to the Plan.

         "Option  Agreement"  shall mean an Option  Agreement to be entered into
between  the  Company  and an  Optionee,  which  shall  set  forth the terms and
conditions of the Options granted to such Optionee.

         "Optionee"  shall mean an Employee  to whom an Option has been  granted
pursuant to the Plan.

         "Parent"  shall mean any  corporation  (other  than the  Company) in an
unbroken  chain  of  corporations  ending  with  the  Company  if  each  of  the
corporations  (other than the Company),  or if each group of commonly controlled
corporations, then (i) is the "beneficial owner" (as defined in Rule 13d-3 under
the Exchange Act),  directly or indirectly,  of securities of one or more of the
other corporations in such chain representing fifty percent (50%) or more of the
combined  voting power for the election of directors  for such  corporation,  or
(ii) if the  determination of whether a corporation is a Parent is being made to
determine whether the requirements  governing  Incentive Stock Options have been
met, owns stock  possessing  fifty  percent (50%) or more of the total  combined
voting power of all classes of stock of such corporation.

         "Payment  Date" shall mean a date not later than ten (10) business days
following the Change in Control Date.

         "Permanent  Disability"  shall  mean  that the  Employee  has  suffered
physical or mental  incapacity of such nature as to prevent him from engaging in
or performing the principal duties of his customary  employment or occupation on
a continuing or sustained basis,  provided that, if an Employee has entered into
an employment agreement with the Company, the Committee, in its sole discretion,
may determine to substitute  the  definition  set forth in such  agreement.  All
determinations  as to the date and extent of disability of any Employee shall be
made by the Committee  upon the basis of such evidence as it deems  necessary or
desirable.

         "Plan" shall mean this Express  Scripts,  Inc.  1994 Stock Option Plan,
as hereinafter amended from time to time.

         "Related  Entity"  shall mean a Parent,  a  Subsidiary  or any employee
benefit plan  (including a trust forming a part of such Plan)  maintained by the
Company, a Parent or a Subsidiary.

         "Restricted Shares" shall mean Shares which are received by an Optionee
upon the exercise of an Option and are subject to the restrictions  described in
Section 4.2(c).

         "Restriction  Period"  shall mean the period  during  which  Restricted
Shares are subject to the restrictions set forth in Section 4.2(c).

         "Retirement" shall mean Early Retirement or Normal Retirement.

         "Securities Act" shall mean the Securities Act of 1933, as amended.

         "Share" shall mean a share of the Company's  Class A Common Stock,  .01
par value.

         "Stockholder Approval Date" shall have the meaning set forth in Section
 7.1.

         "Subsidiary"  shall  mean  any  corporation  in an  unbroken  chain  of
corporations  beginning with the Company,  if each such corporation  (other than
the last  corporation  in the  unbroken  chain),  or if each  group of  commonly
controlled  corporations,  then owns  fifty  percent  (50%) or more of the total
combined voting power in one of the other corporations in such chain.

         "Ten-Percent  Stockholder" shall mean an Employee,  who, at the time an
Incentive  Stock  Option is to be  granted to the  Employee,  owns  (within  the
meaning of Section 422(b)(6) of the Code) stock possessing more than ten percent
(10%) of the total combined voting power of all classes of stock of the Company,
a Parent or a Subsidiary.

         "Termination   of   Employment"   shall   mean   the   time   when  the
employee-employer relationship between the Employee and the Company, a Parent or
a  Subsidiary  is  terminated  for any  reason  whatsoever,  but  excluding  any
termination where there is a simultaneous  reemployment by either the Company, a
Parent or a Subsidiary.

2.       Shares Subject to the Plan

2.1      Shares Subject to Plan

         The maximum number of Shares that may be issued or transferred pursuant
to Options under this Plan shall initially be 210,000. The Company shall reserve
such number of Shares for the purposes of the Plan,  out of its  authorized  but
unissued Shares or out of Shares held in the Company's  treasury,  or partly out
of each.  If any Shares that have been  subject to an Option cease to be subject
thereto,  or any Restricted  Shares received by an Optionee upon the exercise of
an Option are forfeited to the Company in accordance with the Option  Agreement,
such Shares may again be the subject of Options hereunder.

2.2      Changes in Company's Shares

         In the event that the outstanding  Shares are hereafter changed into or
exchanged  for a different  number or kind of shares or other  securities of the
Company, or of another corporation, by reason of reorganization, merger or other
subdivision,  consolidation,  recapitalization,  reclassification,  stock split,
issuance of warrants or rights, stock dividend, combination of shares or similar
event,  appropriate adjustments shall be made by the Committee in the number and
kind of Shares  subject to and which may be subject to Options  under this Plan,
and the purchase  price per Share,  to prevent  dilution or  enlargement  of the
benefits granted to, or available for, Optionees,  including  adjustments of the
limitations in Section 2.1 of the maximum number and kind of shares which may be
issued hereunder as Shares.

3.       Eligibility for Option Grants

         Any Employee who is employed on the senior staff, or as a member of the
sales force or who is  designated  by the  Committee as a key Employee  shall be
eligible to receive  Options  under this Plan.  In no event shall any Options be
granted to any member of the Board who is not an Employee.  The Committee  shall
from time to time, in its sole discretion:

         (a) select from among the eligible Employees  (including  Optionees who
have  previously  received  Options)  such of them as in its  opinion  should be
permitted to receive Options under this Plan;

         (b) determine the number of Shares to be subject to each Option granted
to such selected Employees;  provided, that in no event shall Options be granted
to any Employee in excess of 150,000;

         (c) determine the terms and conditions applicable to each Option (which
need not be identical), consistent with the Plan; and

         (d)  establish  such  conditions  as to the manner of  exercise of such
Options  as it may deem  necessary,  including  but not  limited  to,  requiring
Optionees  to  enter  into  agreements   regarding   transferability  and  other
restrictions with respect to Shares issuable upon exercise of such Options.

4        Terms of Options and Shares

4.1      Option Agreement

         Options  shall be granted only pursuant to an Option  Agreement,  which
shall be executed by the Optionee and an  authorized  officer of the Company and
which shall contain such terms and conditions as the Committee shall  determine,
consistent  with the  Plan,  including  appropriate  vesting  arrangements.  The
aggregate  Fair Market Value  (determined as of the date of grant) of the Shares
with respect to which  Incentive  Stock Options  granted under this Plan and all
other  option  plans  of the  Company,  the  Parent  and any  Subsidiary  become
exercisable by an Employee  during any calendar year shall not exceed  $100,000.
To the extent the  limitation  set forth in the preceding  sentence is exceeded,
the Options with respect to such excess amount shall be treated as  Nonqualified
Stock Options.

4.2      Terms

         The  Options  granted  hereunder  shall  have the  following  terms and
conditions:

         (a) Price.  The purchase price for the Shares subject to an Option,  or
the manner in which such purchase price is to be determined, shall be determined
by the Committee, in its sole discretion, and set forth in the Option Agreement,
provided  that the  purchase  price per Share shall not be less than one hundred
percent  (100%) of the Fair Market Value of a Share as of the date the Option is
granted (110% in the case of an Incentive  Stock Option granted to a Ten-Percent
Stockholder).

         (b)  Term.  Options  shall  be for  such  term as the  Committee  shall
determine, and as shall be set forth in each Option Agreement,  provided that no
Option shall be  exercisable  after the expiration of ten years from the date it
is granted  (five years in the case of an Incentive  Stock  Option  granted to a
Ten-Percent Stockholder).

         (c) Vesting.  Options shall be exercisable in such installments  (which
need not be equal) and at such times as may be  designated  by the Committee and
set forth in the Option  Agreement.  To the extent not  exercised,  installments
shall  accumulate  and may be exercised,  in whole or in part, at any time after
becoming  exercisable,  but not  later  than the date the  Option  expires.  The
Committee may accelerate the exercisability of any Option, or the vesting of any
Restricted Shares, or portion thereof at any time.

         The Committee may in its  discretion  provide that all or a part of the
Shares received by an Optionee upon the exercise of a Nonqualified  Stock Option
shall be Restricted  Shares subject to any or all of the following  restrictions
or conditions:

                  (i)  Subject  to the  provisions  of the Plan  and the  Option
         Agreement,  during a period set by the  Committee  commencing  with the
         date  of the  grant  of the  Option  (the  "Restriction  Period"),  the
         Optionee may not be permitted to sell,  transfer,  pledge or assign the
         Restricted  Shares. The Committee in its discretion may provide for the
         lapse of such  restrictions in installments and may accelerate or waive
         such  restrictions in whole or in part,  based on service,  performance
         and/or such other factors or criteria as the Committee may determine in
         its discretion,

                  (ii)  Except as  provided  in this  clause (ii) and clause (i)
         above, the Optionee shall have, with respect to the Restricted  Shares,
         all of the rights of a shareholder of the Company,  including the right
         to vote the Shares and the right to receive any cash  dividends.  Stock
         dividends issued with respect to Restricted  Shares shall be treated as
         additional  Restricted Shares that are subject to the same restrictions
         and other terms and conditions that apply to the Shares with respect to
         which such dividends are issued.

                  (iii)  Subject  to the  applicable  provisions  of the  Option
         Agreement and this Section,  upon Termination of Employment  during the
         Restriction  Period, all Shares still subject to restriction will vest,
         or  be  forfeited,   in  accordance   with  the  terms  and  conditions
         established by the Committee at grant.

                  (iv) If and when the  Restriction  Period  expires  without  a
         prior  forfeiture  of  the  Restricted  Shares,   certificates  for  an
         appropriate  number of  unrestricted  Shares  shall be delivered to the
         Optionee promptly.

         (d)  Termination  of  Employment.  Except as provided  in this  Section
4.2(d) or in the Option Agreement  evidencing such an Option,  in the event of a
Termination of Employment of an Optionee,  all outstanding  Options held by such
Optionee shall  terminate  immediately,  provided  that, if such  Termination of
Employment is due to the Optionee's death,  Permanent Disability,  or Retirement
or by the  Company,  a Parent or a Subsidiary  without  Cause,  all  outstanding
Options held by such Optionee shall immediately  become fully exercisable to the
extent not so exercisable, shall remain exercisable for a period of three months
following  such  Termination  of  Employment,  and shall  thereafter  terminate.
Notwithstanding the foregoing, (i) the Committee may provide, either at the time
an Option is granted or thereafter,  that the Option may be exercised  after the
period provided for in this Section  4.2(d),  but in no event beyond the term of
the Option,  and (ii) no  provision  in this  Section  4.2(d)  shall  extend the
exercise period of an Option beyond its original term.

4.3      Non-Transferability

         No Option granted under the Plan shall be  transferable by the Optionee
to whom granted  otherwise than by will or the laws of descent and distribution,
and an Option may be exercised  during the lifetime of such Optionee only by the
Optionee or his guardian or legal representative. The terms of such Option shall
be  binding  upon  the  beneficiaries,   executors,  administrators,  heirs  and
successors of the Optionee.

4.4      Method of Exercise

         The  exercise  of an  Option  shall be made  only by a  written  notice
delivered in person or by mail to the  Secretary of the Company at the Company's
principal executive office,  specifying the number of Shares to be purchased and
accompanied by full payment therefor and otherwise in accordance with the Option
Agreement  pursuant to which the Option was granted.  The purchase price for any
Shares  purchased  pursuant to the  exercise of an Option  shall be paid in full
upon such exercise in cash, by check or, at the  discretion of the Committee and
upon such terms and conditions as the Committee  shall approve,  by transferring
previously  owned Shares to the Company,  having  Shares  withheld or exercising
pursuant to a "cashless exercise"  procedure,  or any combination  thereof.  Any
Shares  transferred  to the  Company as payment of the  purchase  price under an
Option shall be valued at their Fair Market Value on the day  preceding the date
of exercise of such Option.  If requested by the  Committee,  the Optionee shall
deliver  the Option  Agreement  evidencing  the Option to the  Secretary  of the
Company who shall  endorse  thereon a notation of such  exercise and return such
Option Agreement to the Optionee.  Not less than one hundred (100) Shares may be
purchased at any time upon the exercise of an Option unless the number of Shares
so purchased  constitutes the total number of Shares then purchasable  under the
Option or the Committee determines otherwise in its sole discretion.

4.5      Rights as Stockholder

         No Optionee shall be deemed for any purpose to be or to have the rights
and privileges of the owner of any Shares subject to any Option unless and until
(a) the Option shall have been exercised pursuant to the terms thereof,  and (b)
the Company shall have issued the Shares to the Optionee.

5.       Change in Control Provisions

5.1      Impact of Change in Control Event

         Notwithstanding  anything  herein  to the  contrary,  in the event of a
Change  in  Control  (i) all  outstanding  Options,  whether  or not  previously
exercisable and vested, shall terminate  immediately and become null and void on
the Change in Control Date, and (ii) any Restricted  Shares shall be redeemed by
the Company and  canceled as of the Change in Control  Date;  and in either case
the Company shall pay such Optionee the amount, if any, determined in accordance
with Section 5.2 in lieu of such options or Restricted Shares.

5.2      Payment for Options and Restricted Shares

         (a) No Offer of  Comparable  Employment.  If an Optionee is not offered
Comparable  Employment  with  the  Company  or any  successor  to the  Company's
business on or prior to the Change in Control  Date,  the Company  shall pay the
Optionee for each of his Options that was terminated  pursuant to Section 5.1 an
amount  equal to the  excess,  if any of the  Change in  Control  Price over the
purchase  price for the shares subject to such Option,  and for each  Restricted
Share that was redeemed and  canceled,  an amount equal to the Change in Control
Price.  Such aggregate  amount shall be paid to the Optionee by the Company in a
cash lump sum on the Payment Date.

         (b) Offer of Comparable  Employment Accepted. If an Optionee is offered
and  accepts  Comparable  Employment  with the Company or any  successor  to the
Company's  business,  the Company shall pay the Optionee for each of his Options
that was canceled pursuant to Section 5.1 an amount equal to the excess, if any,
of the Change in Control Price over the purchase price for the shares subject to
such Option,  and for each Restricted  Share that was redeemed and canceled,  an
amount equal to the Change in Control Price. Such aggregate amount shall be paid
to the Optionee as follows:

                  (i) any amount  attributable to Options that were vested on or
         prior to the Change in Control  Date shall be paid to the  Optionee  on
         the Payment Date.

                  (ii) any amount attributable to Options that would have become
         vested  after  the  Change  in  Control  Date but  prior to the  second
         anniversary of the Change in Control Date, or to Restricted  Shares the
         transferability and forfeiture  restrictions on which would have lapsed
         during such period,  shall be paid to the Optionee on the date that the
         Options  otherwise  would  have  vested  or the  restrictions  on  such
         Restricted Shares otherwise would have lapsed, as the case may be; and

                  (iii) any other  amounts due to the Optionee and not disbursed
         pursuant  to the  preceding  clauses  (i) and (ii) shall be paid in two
         cash installments on the first and second  anniversary of the Change in
         Control  Date,  the first  installment  being  equal to one-half of the
         amount that would have been paid in the absence of the preceding clause
         (ii)  above  minus the amount of any  payment  made prior to such first
         installment  pursuant  to the  preceding  clause  (ii),  and the second
         installment being equal to the remaining balance due to the Optionee.

Notwithstanding  the  foregoing,  in the event of a Termination of Employment of
the Optionee at any time before such second anniversary, other than by reason of
(A) the Optionee's death, Permanent Disability or Retirement, (B) termination by
the Company or any successor to the Company's  business  without  Cause,  or (C)
termination  by the Employee  after his  employment  ceases for any reason to be
Comparable Employment,  the Optionee shall forfeit any right to, an shall not be
paid,  any unpaid  installments.  In the case of a Termination of Employment for
any reason  specified in clause (A), (B) or (C) of the preceding  sentence,  all
unpaid  installments  shall be paid to the  Optionee  in a cash lump sum  within
thirty (30) days of such Termination of Employment.

         (c) Offer of Comparable  Employment Rejected. If an Optionee is offered
Comparable  Employment  with  the  Company  or any  successor  to the  Company's
business  and he rejects  such offer,  the Company  will pay to the Optionee for
each of his Options  that was fully  vested  immediately  prior to the Change in
Control  Date,  an amount equal to the excess,  if any, of the Change in Control
Price over the purchase  price for the shares  subject to such  Option,  and for
each  Restricted  Share that was  redeemed  and  canceled an amount equal to the
lesser of (i) the  Change  in  Control  Price,  or (ii) the  amount  paid by the
Optionee to acquire such Restricted Shares from the Company.  Except as provided
in the  preceding  sentence,  the Company  shall not be required to pay, and the
Optionee  shall not be entitled to receive,  any amount  under this Section 5 or
otherwise in connection with the  cancellation of any other Options  pursuant to
Section 5.1. Any amount  payable to the Optionee  hereunder  shall be payable on
the Payment Date.

5.3      Escrow of Deferred Payments

         (a) Any amount that may become payable to Optionees pursuant to Section
5.2(b) above shall be  deposited on the Payment Date in escrow with a U.S.  bank
with unrestricted capital and surplus of not less than $100,000,000.  Such funds
shall be invested in securities  issued or fully guaranteed as to both principal
and interest by the U.S. Government.  Interest earned shall be allocated ratably
among the  Optionees  receiving  payment of such funds and,  if any  amounts are
forfeited by an  Optionee,  to the  Company,  and shall be  disbursed  when such
payments are made.

         (b)      Disbursements

                  (i)  Subject to the  following  clauses  (ii) and  (iii),  the
         escrow  agreement  shall  provide for  disbursements  to  Optionees  in
         accordance with a schedule  attached thereto and prepared in accordance
         with Section 5.2(b)(ii) and (iii).

                  (ii) If an Optionee  forfeits his rights to any payments  from
         the   escrow,   the  Company   shall  give   written   notice   thereof
         contemporaneously  to the escrow agent and the Optionee by certified or
         registered mail (in the case of the Optionee, to the last known address
         of the Optionee on the records of the Company),  stating the reason for
         such forfeiture and the amount thereof. The escrow agent shall disburse
         the amount stated in such notice to the Company  thirty (30) days after
         receipt  thereof  unless prior to such time the escrow  agent  receives
         written notice of objection from the Optionee. If a notice of objection
         is received, the escrow agent shall disburse such funds only upon order
         of a court  of  competent  jurisdiction  or upon  written  instructions
         signed by both the Company and the Optionee.

                  (iii) If an Optionee  or his  successor  in  interest  becomes
         entitled to a payment  from the escrow  prior to the time stated in the
         schedule,  the Optionee or such  successor  shall give  written  notice
         thereof  contemporaneously  to the  escrow  agent  and the  Company  by
         certified or registered  mail,  stating the reason for such accelerated
         payment and the amount  thereof.  The escrow  agent shall  disburse the
         amount stated in such notice to the Optionee or such  successor  thirty
         (30) days after  receipt  thereof  unless prior to such time the escrow
         agent  receives  written  notice of objection  from the  Company.  If a
         notice of objection is received,  the escrow agent shall  disburse such
         funds  only upon  order of a court of  competent  jurisdiction  or upon
         written instructions signed by both the Company and the Optionee.

5.4      Parachute Payments

         In the event that the  aggregate  present  value of the  payments to an
Optionee under this Plan, and any other plan, program, or arrangement maintained
by the Company (a Subsidiary or, if applicable, a Parent) constitutes an "excess
parachute  payment"  (within the meaning of Section  280G(b)(1) of the Code) and
the excise tax on such payment  would cause the net  parachute  payments  (after
taking into account  federal,  state and local income and excise taxes) to which
the  Optionee  otherwise  would be  entitled,  to be less than what the Optionee
would have netted  (after  taking into account  federal,  state and local income
taxes) had the present value of his total parachute  payments equaled $1.00 less
than three times his "base amount" (within the meaning of Section  280G(b)(3)(A)
of the Code), the Optionee's total "parachute  payments"  (within the meaning of
Section  280G(b)(2)(A)  of the Code) shall be reduced  (by the minimum  possible
amount) so that their aggregate present value equals $1.00 less than three times
such base amount. For purposes of this calculation, it shall be assumed that the
Optionee's tax rate will be the maximum marginal federal, state and local income
tax rate on earned  income,  with such maximum  federal rate to be computed with
regard  to  Section  1(g) of the Code,  if  applicable.  In the  event  that the
Optionee and the Company or any successor to the  Company's  Business are unable
to agree as to the amount of the reduction described above, if any, the Optionee
shall select a law firm or accounting firm from among those regularly  consulted
(during the twelve-month  period immediately prior to the Change in Control that
resulted in the  characterization  of the payments as parachute payments) by the
Company  regarding  federal income tax or employee  benefit matters and such law
firm or accounting firm shall determine, at the Company's expense, the amount of
such  reduction  and such  determination  shall be final  and  binding  upon the
Optionee and the Company or such successor.

6.       Administration

6.1      Compensation Committee

         The Plan shall be  administered by the Committee which shall consist of
at least three  directors  of the  Company,  appointed  by the Board and holding
office at the pleasure of the Board.  All Committee  members shall be members of
the Board. All members of the Committee must be "disinterested persons," as such
term  is  described  in  Rule  16b-3  adopted  by the  Securities  and  Exchange
Commission  under the Exchange  Act, if and as such Rule is in effect and to the
extent  required by Section 162(m) of the Code and the  Regulations  promulgated
thereon, an "outside director" within the meaning thereof.

6.2      Duties and Powers of Committee

         It  shall  be  the  duty  of  the  Committee  to  conduct  the  general
administration  of the Plan in  accordance  with its terms and  provisions.  The
Committee  shall have the power to interpret the Plan and the Option  Agreements
and to adopt such rules for the  administration,  interpretation and application
of the Plan as are  consistent  therewith and to interpret,  amend or revoke any
such rules.

6.3      Majority Rule

         The  Committee  shall act by a majority of its  members in office.  The
Committee  may act  either  by vote at a  telephonic  or other  meeting  or by a
memorandum or other written instrument signed by a majority of the Committee .

6.4      Compensation; Professional Assistance; Good Faith Actions

         Members  of the  Committee  may  receive  such  compensation  for their
services  as  members  as may be  determined  by the  Board.  All  expenses  and
liabilities  incurred  by  members  of the  Committee  in  connection  with  the
administration  of the Plan shall be borne by the  Company.  The  Committee  may
employ attorneys,  consultants,  accountants,  appraisers, or other persons. The
Committee,  the Company and its officers and directors shall be entitled to rely
upon the advice,  opinions or valuations of any such persons.  All actions taken
and all  interpretations  and determinations made by the Committee in good faith
shall be final  and  binding  upon all  Optionees,  the  Company  and all  other
interested  persons.  No member of the Committee shall be personally  liable for
any action,  determination or interpretation  made in good faith with respect to
the  Plan or the  Options,  and all  members  of the  Committee  shall  be fully
protected  by the  Company  in  respect  to any such  action,  determination  or
interpretation.

7.       Other Provisions

7.1      Effective Date

         (a) Effective  Date. The Plan shall become  effective as of the date of
the adoption of the Plan by the Board,  subject to the approval of the Plan by a
majority  of the  Company's  stockholders  (the  "Effective  Date"),  and  shall
continue  in effect  until  June 6, 2004 or until the  Change in  Control  Date,
whichever is sooner; provided, that termination of the Plan shall not affect the
rights of any Optionee  with  respect to Options  granted or  Restricted  Shares
acquired  contemporaneously  with or prior to such termination.  Notwithstanding
anything  herein or in any Option  Agreement to the  contrary,  Options  granted
hereunder  shall  not  vest  and  may  not be  exercised  prior  to the  date of
stockholder  approval (the "Stockholder  Approval Date"), and, in the event that
the  Stockholder  Approval Date has not occurred on or prior to June 6, 1995 (or
such later date as determined by the Board in its sole discretion),  all Options
granted prior to such date shall be null and void and of no effect,  retroactive
to the  date of  grant,  and the Plan  shall be null and void and of no  effect,
retroactive to the date of Board approval.

         (b) Effect of Certain Amendments.  The amendments approved by the Board
of Directors on March 22, 1995,  other than the amendments to sections 2.1, 3(b)
and 6.1 hereof,  shall be effective  only with respect to Options  granted after
such date, provided,  however, that the Committee may enter into agreements with
Optionees  whose options were granted prior to such date to make such amendments
applicable, in whole or in part, to such Options.

7.2      Amendment, Suspension or Termination of the Plan

         The Plan may be wholly or  partially  amended  or  otherwise  modified,
suspended or terminated at any time or from time to time by the Board; provided,
however,  that,  except as  provided  in  Section  2.2,  no  amendment  shall be
effective  unless  approved by the  affirmative  vote of a majority of the votes
eligible  to be cast at a meeting of  stockholders  of the  Company  held within
twelve  (12)  months  of the date of  adoption  of such  amendment,  where  such
amendment will:

     (a) increase the number of Shares as to which  Options may be granted under
the Plan;

     (b) change the class of persons eligible to participate in the Plan;

     (c) change the  minimum  purchase  price of Shares  pursuant  to Options as
provided herein;

     (d) extend the maximum period for granting or exercising  Options  provided
herein; or

     (e) otherwise  materially increase the benefits accruing to Optionees under
the Plan.

         From and after the Effective  Date,  neither the amendment,  suspension
nor termination of the Plan shall, without the consent of the Optionee, alter or
impair  any  rights or  obligations  under any Option  theretofore  granted.  No
Options may be granted during any period of suspension nor after  termination or
expiration of the Plan.

7.3      Effect of Plan Upon Other Compensation and Incentive Plans

         The  adoption  of the Plan shall not affect any other  compensation  or
incentive plans in effect for the Company or any Subsidiary. Nothing in the Plan
shall be  construed  to limit  the right of the  Company  or any  Subsidiary  to
establish  any other forms of incentives  or  compensation  for Employees of the
Company or any Subsidiary.

7.4      Regulations and Other Approvals; Governing Law

         (a) The Plan and the rights of all persons claiming  hereunder shall be
construed and  determined  in accordance  with the laws of the State of Delaware
without giving effect to the choice of law principles thereof.

         (b) The  obligation  of the  Company  to sell or  deliver  Shares  with
respect to  Options  granted  under the Plan shall be subject to all  applicable
laws,  rules  and  regulations,  including  all  applicable  federal  and  state
securities  laws,  and the  obtaining  of all  such  approvals  by  governmental
agencies as may be deemed necessary or appropriate by the Committee.

         (c) The Board may make such changes as may be necessary or  appropriate
to comply  with the rules and  regulations  of any  government  authority  or to
obtain  the tax  benefits  under  the  applicable  provisions  of the  Code  and
regulations   promulgated  thereunder  for  Employees  granted  Incentive  Stock
Options.

         (d) Each Option is subject to the requirement  that, if at any time the
Committee determines, in its sole discretion, that the listing,  registration or
qualification  of  Shares  issuable  pursuant  to the  Plan is  required  by any
securities  exchange  or under any  state or  federal  law,  or the  consent  or
approval of any  governmental  regulatory  body is  necessary  or desirable as a
condition of, or in connection  with,  the grant of an Option or the issuance of
Shares,  no Options shall be granted or payment made or Shares issued,  in whole
or in part, unless listing, registration, qualification, consent or approval has
been effected or obtained free of any conditions as acceptable to the Committee.

         (e) In the event that the  disposition of Shares  acquired  pursuant to
the Plan is not  covered  by a then  current  registration  statement  under the
Securities Act, and is not otherwise exempt from such registration,  such Shares
shall be restricted  against  transfer to the extent  required by the Securities
Act or  regulations  thereunder,  and the Committee  may require any  individual
receiving  Shares  pursuant to the Plan, as a condition  precedent to receipt of
such Shares,  to represent to the Company in writing that the Shares acquired by
such  individual  are  acquired  for  investment  only  and  not  with a view to
distribution.  The  certificate  for such  shall  include  any  legend  that the
Committee deems appropriate to reflect any restrictions on transfer.

7.5      Withholding of Taxes

         No later than the date as to which an amount first  becomes  includable
in the gross income of an Optionee for Federal  income tax purposes with respect
to any Option granted under the Plan, the Optionee shall pay to the Company,  or
make  arrangements  satisfactory to the Committee  regarding the payment of, any
Federal,  state, or local taxes of any kind required by law or the Company to be
withheld with respect to such amount.  The  obligations of the Company under the
Plan shall be conditional  on such payment or  arrangements  and the Company,  a
Parent and any Subsidiary  shall, to the extent  permitted by law have the right
to deduct  any such  taxes from any  payment  of any kind  otherwise  due to the
Optionee.  In its  discretion,  the  Committee  may permit  Optionees to satisfy
withholding  obligations by delivering previously owned Shares or by electing to
have Shares withheld.

7.6      No Right to Continued Employment

         Nothing in the Plan or in any Option  Agreement  shall  confer upon any
Optionee  any right to  continue in the employ of the  Company,  a Parent or any
Subsidiary  or shall  interfere  with or  restrict  in any way the  right of the
Company, a Parent and any Subsidiary,  which are hereby expressly  reserved,  to
remove,  terminate  or  discharge  any  Optionee  at any  time  for  any  reason
whatsoever, with or without Cause.

7.7      Titles; Construction

         Titles are provided herein for convenience only and are not to serve as
a basis for  interpretation  or construction of the Plan. The masculine  pronoun
shall include the feminine and neuter and the singular shall include the plural,
when the context so indicates.

         Prior to amendment and  restatement,  Section 5, which will continue to
govern  currently  outstanding  awards of stock options and  restricted  shares,
formerly provided as follows:

5.       Change in Control Provisions

         In the event of a Change in Control,  (a) all  outstanding  Options not
previously exercisable and vested shall immediately become fully exercisable and
vested, and (b) the  transferability and forfeiture  restrictions  applicable to
any  Restricted  Shares to the extent not  already  lapsed,  shall  lapse and no
longer be applicable,  and such Shares shall be deemed fully vested and owned by
the Optionee.

         "Change in Control"  shall mean the  occurrence of any of the following
events at a time when New York Life  Insurance  Company,  A New York mutual life
insurance company, or any successor thereto is not a Parent:

                  (i) any  "person,"  as such term is used in Section  13(d) and
         14(d) of the Exchange Act, (other than the Company or a Related Entity,
         without the approval of the Board,  becomes the "beneficial  owner" (as
         defined in Rule 13d-3 under the Exchange Act),  directly or indirectly,
         of securities of the Company  representing  fifty percent (50%) or more
         of the  combined  voting  power for the  election of  directors  of the
         Company's then outstanding securities;

                  (ii) during any period of two  consecutive  years beginning on
         or  after  the  effective  date  of the  Plan,  individuals  who at the
         beginning  of such period  constitute  the Board,  and any new director
         (other than a director  designated  by a person who has entered into an
         agreement with the Company to effect a transaction  described in clause
         (i),  (iii) or (iv))  whose  election  by the Board or  nomination  for
         election by the  Company's  shareholders  was  approved by a vote of at
         least two-thirds (2/3) of the directors then still in office who either
         were  directors  at the  beginning  of the period or whose  election or
         nomination for election was previously so approved (unless the approval
         of the election or nomination for election of such new directors was in
         connection  with an actual or  threatened  election or proxy  contest),
         cease for any reason to constitute at least a majority thereof;

                  (iii)  the  shareholders  of the  Company  approve a merger or
         consolidation of the Company with any other corporation, other than (x)
         a merger or consolidation  which would result in the voting  securities
         of the Company  outstanding  immediately  prior  thereto  continuing to
         represent  (either by remaining  outstanding or by being converted into
         voting  securities  of the surviving  entity) more than eighty  percent
         (80%) of the  combined  voting  power of the voting  securities  of the
         Company or such surviving  entity  outstanding  immediately  after such
         merger or consolidation  or (y) a merger or  consolidation  effected to
         implement a recapitalization of the Company (or similar transaction) in
         which no "person" (as defined  above in clause (i))  acquires more than
         fifty  percent  (50%) of the combined  voting power for the election of
         directors of the Company's then outstanding securities; or

                  (iv)  the  shareholders  of the  Company  approve  a  plan  of
         complete  liquidation  of the Company or an  agreement  for the sale or
         disposition by the Company of all or substantially all of the Company's
         assets or any transaction having a similar effect.

<PAGE>


                               FIRST AMENDMENT TO
                              EXPRESS SCRIPTS, INC.
                   AMENDED AND RESTATED 1994 STOCK OPTION PLAN

                                    RECITALS

     A. Express  Scripts,  Inc. (the "Company") has an Amended and Restated 1994
Stock Option Plan (the "Plan")  which was amended and restated on March 22, 1995
and approved by the stockholders on May 24, 1995.

     B. On January 29, 1997, the Board of Directors of the Company (the "Board")
approved an increase in the number of shares which may be issued pursuant to the
Plan.

                                    AMENDMENT

     1. Definitions.  Capitalized terms set forth in this First Amendment to the
Plan (the "First Amendment") shall be as defined in the Plan.

2. Amendment to Section 2.1, Shares Subject to Plan.  Section 2.1 of the Plan is
amended by  deleting  the number  "210,000"  in the first  sentence  thereof and
inserting in lieu thereof the number "460,000."

3. Effective Date of the First Amendment;  Stockholder  Approval.  The effective
date of this First  Amendment  shall be January 29, 1997.  This First  Amendment
shall be submitted for the approval of the  stockholders  of the  Corporation at
the next annual  meeting  thereof on May 28,  1997,  and if not  approved by the
stockholders this First Amendment shall be null and void.

<PAGE>

                               SECOND AMENDMENT TO
                              EXPRESS SCRIPTS, INC.
                   AMENDED AND RESTATED 1994 STOCK OPTION PLAN

                                    RECITALS

A. Express Scripts,  Inc. (the "Company") has an Amended and Restated 1994 Stock
Option Plan which was amended and restated on March 22, 1995 and approved by the
stockholders on May 24, 1995, and which was subsequently amended by the Board of
Directors of the Company  (the  "Board")  and  approved by the  stockholders  on
January 29, 1997 and May 29, 1997, respectively (as amended, the "Plan").

B. On January 27, 1998,  the Board  approved an increase in the number of shares
which may be issued pursuant to the Plan.

                                    AMENDMENT

1. Definitions. Capitalized terms set forth in this Second Amendment to the Plan
(the "Second Amendment") shall be as defined
in the Plan.

2. Amendment to Section 2.1, Shares Subject to Plan.  Section 2.1 of the Plan is
amended by  deleting  the number  "460,000"  in the first  sentence  thereof and
inserting in lieu thereof the number "960,000."

3. Effective Date of the Second Amendment;  Stockholder Approval.  The effective
date of this Second  Amendment shall be January 27, 1998. This Second  Amendment
shall be submitted for the approval of the  stockholders  of the  Corporation at
the next annual  meeting  thereof on May 27,  1998,  and if not  approved by the
stockholders this Second Amendment shall be null and void.

<PAGE>

                               THIRD AMENDMENT TO
                              EXPRESS SCRIPTS, INC.
                   AMENDED AND RESTATED 1994 STOCK OPTION PLAN

                                    RECITALS

A. Express Scripts,  Inc. (the  "Corporation")  has an Amended and Restated 1994
Stock Option Plan, which was amended and restated on March 22, 1995 and approved
by the stockholders on May 24, 1995, and which was  subsequently  amended by the
Board of  Directors  of the  Corporation  (the  "Board") on January 29, 1997 and
January  27,  1998,  and  such  subsequent   amendments  were  approved  by  the
stockholders on May 28, 1997 and May 27, 1998, respectively (the "1994 Plan").

B. On March 24,  1999,  the Board  approved  an increase in the number of shares
that the  Company may issue  pursuant  to the 1994 Plan and  certain  additional
amendments to the 1994 Plan.

                                    AMENDMENT

1. Definitions.  Capitalized  terms set forth in this  Third  Amendment  to the
1994 Plan  (the  "Third  Amendment")  shall be as defined in the 1994 Plan.

2. Amendment to Section 1, Definition of "Early  Retirement".  The definition of
the term  "Early  Retirement"  in  Section  1 of the  1994  Plan is  amended  by
inserting at the end of clause (ii) the additional language set forth below:

         , provided,  however,  that a non-qualified  deferred compensation plan
         shall  not  be  deemed  to be a  pension  plan  for  purposes  of  this
         definition.

3. Amendment to Section 1, Definition of "Normal Retirement".  The definition of
the term  "Normal  Retirement"  in  Section  1 of the 1994  Plan is  amended  by
inserting at the end of clause (ii) the additional language set forth below:

         , provided,  however,  that a non-qualified  deferred compensation plan
         shall  not  be  deemed  to be a  pension  plan  for  purposes  of  this
         definition.

4.  Amendment to Section 1,  Definition  of "Plan".  The  definition of the term
"Plan" in Section 1 of the 1994 Plan is amended by deleting  such  definition in
its entirety and replacing it with the language set forth below:

               "Plan"  shall mean this Express  Scripts,  Inc.  Amended and
          Restated  1994 Stock Option Plan, as amended from time to time.

5. Amendment  to  Section  2.1,  Shares  Subject  to Plan.  Section  2.1 of the
1994 Plan is  amended  to read as  follows in its entirety:

                  The maximum number of Shares that may be issued or transferred
         pursuant to Options under this Plan shall be 2,920,000,  which has been
         adjusted to reflect the stock split effected on October 30, 1998.  Such
         number of Shares shall increase annually,  effective as of each January
         1,  commencing  on January 1, 2000 and ending on January 1, 2004, by an
         amount  equal to one (1)  percent of the  Company's  total  outstanding
         shares of Class A and Class B Common  Stock on such date.  The  Company
         shall reserve such number of Shares for the purposes of the Plan out of
         its  authorized  but  unissued  Shares  or out of  Shares  held  in the
         Company's treasury, or partly out of each. If any Shares that have been
         subject to an Option  cease to be subject  thereto,  or any  Restricted
         Shares  received  by an  Optionee  upon the  exercise  of an Option are
         forfeited to the Company in accordance with the Option Agreement,  such
         Shares may again be the subject of Options hereunder.

6.  Amendment to Section 2.2,  Changes in Company's  Shares.  Section 2.2 of the
1994 Plan is hereby  amended by inserting at the end of the single  paragraph of
such section the additional language set forth below:

         and adjustments of the limitation in Section 3(b) of the maximum number
         of Shares subject to Options that may be granted to any Employee.

7. Amendment to Section 3, Eligibility for Option Grants.  Section 3 of the 1994
Plan is hereby  amended by deleting  paragraph (b) in its entirety and replacing
it with the  language  set forth below to reflect  the stock  split  effected on
October 30, 1998:

         (b) determine the number of Shares to be subject to each Option granted
to such selected Employees;  provided, that in no event shall Options be granted
to any Employee in excess of 300,000;

8. Amendment  to  Section  4.4,  Method of  Exercise.  Section  4.4 of the 1994
Plan is hereby  amended  by  deleting  the second sentence thereof and replacing
it with the language set forth below:

         The purchase price for any Shares purchased pursuant to the exercise of
         an Option  shall be paid in full upon such  exercise in cash,  by check
         or,  at the  discretion  of the  Committee  and  upon  such  terms  and
         conditions as the Committee shall approve,  by transferring  previously
         owned Shares to the Company  (including  by way of  attestation  of the
         Optionee's  ownership  of  such  Shares),  having  Shares  withheld  or
         exercising  pursuant  to  a  "cashless  exercise"  procedure,   or  any
         combination thereof.

9. Amendment to Section 6.1,  Compensation  Committee.  Section 6.1 of the 1994
Plan is hereby  amended by deleting  such section in its entirety and replacing
it with the language set forth below:

         6.1      Compensation Committee

                  The Plan shall be  administered  by the Committee  which shall
         consist of at least three  directors of the  Company,  appointed by the
         Board and holding  office at the pleasure of the Board.  All  Committee
         members shall be members of the Board.

10. Effective Date of the Third Amendment;  Stockholder Approval.  The effective
date of this Third Amendment shall be March 24, 1999. This Third Amendment shall
be submitted for the approval of the stockholders of the Corporation at the next
annual  meeting   thereof  on  May  26,  1999,  and,  if  not  approved  by  the
stockholders, this Third Amendment shall be null and void.




                                                                     Exhibit 5.1

                                  June 4, 1999
Express Scripts, Inc.
13900 Riverport Drive
Maryland Heights, Missouri 63043

Ladies and Gentlemen:

                  I am Senior Vice President of Administration,  General Counsel
and Secretary of Express Scripts,  Inc., a Delaware corporation (the "Company"),
and in such capacity I am familiar with the  Registration  Statement on Form S-8
to which this  opinion is filed as an exhibit  (the  "Registration  Statement"),
which  registers  under the Securities Act of 1933, as amended (the  "Securities
Act"),  2,660,000 shares (the "Shares") of Class A Common Stock, par value $.01,
of the Company (the  "Shares")  reserved for issuance and to be issued from time
to time pursuant to the Express  Scripts,  Inc.  Amended and Restated 1994 Stock
Option Plan, as amended (the "Plan").

                  I have examined  originals or copies,  certified or otherwise,
identified  to  my   satisfaction,   of  such  documents,   corporate   records,
certificates of public officials and other instruments as I deemed necessary for
the purposes of the opinion expressed herein. I have assumed (i) the genuineness
of all signatures on all documents  examined by me, (ii) the authenticity of all
documents  submitted  to me as  originals,  (iii) the  conformity  to  authentic
originals of all documents  submitted to me as certified or photostatic  copies,
and (iv) the due authorization, execution and delivery of all documents.

                  On the basis of the  foregoing,  I am of the opinion that when
the Registration Statement,  including any amendments thereto, shall have become
effective  under  the  Securities  Act,  and the  Shares  have  been  issued  in
accordance  with the terms of the Plan,  then the Shares will be legally issued,
fully paid and nonassessable.

                  This  opinion is not  rendered  with respect to any laws other
than (i) the laws of the State of Delaware and (ii)  applicable  federal laws. I
do not assume any duty to update this  opinion with respect to changes of law or
fact occurring after the date hereof.

                  I consent to the  filing of this  opinion as an exhibit to the
Registration  Statement. I also consent to your filing copies of this opinion as
an exhibit to the  Registration  Statement  with such agencies of such states as
you deem  necessary  in the  course of  complying  with the laws of such  states
regarding the offering and sale of the Shares. In giving this consent,  I do not
admit that I am in the  category  of persons  whose  consent is  required  under
Section 7 of the Securities  Act or the rules and  regulations of the Securities
and Exchange Commission.

                         Very truly yours,

                         /s/ Thomas M. Boudreau
                         Thomas M. Boudreau
                         Senior Vice President of Administration,
                         General Counsel and Secretary





                                                                   Exhibit 23.1



                       Consent of Independent Accountants



We  hereby  consent  to the  incorporation  by  reference  in the  Registration
Statement on Form S-8 of Express Scripts,  Inc. of our report dated February 12,
1999 relating to the financial  statements  and  financial  statement  schedule,
which appears in Express Scripts, Inc.'s Annual Report on Form 10-K for the year
ended December 31, 1998.


/s/ PricewaterhouseCoopers LLP
PricewaterhouseCoopers LLP
St. Louis, Missouri
June 7, 1999



                                                                  Exhibit 23.2

                          Consent of Ernst & Young LLP


We consent to the incorporation by reference in this  Registration  Statement on
Form S-8 pertaining to the Amended and Restated Express Scripts, Inc. 1994 Stock
Option Plan,  As Amended of our report  dated June 4, 1998,  with respect to the
combined  financial  statements  of Value  Health  Pharmacy  Benefit  Management
included in Express Scripts,  Inc.'s Current Report on Form 8-K/A dated June 12,
1998, filed with the Securities & Exchange Commission.


                                                 /s/ Ernst & Young LLP


Minneapolis, Minnesota
June 7, 1999




                                                                    Exhibit 23.3


                          Consent of Ernst & Young LLP


We consent to the incorporation by reference in this  Registration  Statement on
Form S-8 pertaining to the Amended and Restated Express Scripts, Inc. 1994 Stock
Option Plan,  As Amended of our report  dated June 1, 1998,  with respect to the
financial  statements  of Managed  Prescription  Network,  Inc.  d/b/a  Columbia
Pharmacy  Solutions  included in Express Scripts,  Inc.'s Current Report on Form
8-K/A dated June 12, 1998, filed with the Securities & Exchange Commission.


                                                    /s/ Ernst & Young LLP



Pittsburgh, Pennsylvania
June 7, 1999






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