EXPRESS SCRIPTS INC
10-K, 1999-03-29
SPECIALTY OUTPATIENT FACILITIES, NEC
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 10-K


     X ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES  EXCHANGE
       ACT OF 1934 FOR THE FISCAL YEAR ENDED DECEMBER 31, 1998, OR

       TRANSITION  REPORT  PURSUANT  TO  SECTION  13 OR 15(d) OF THE SECURITIES
       EXCHANGE  ACT  OF  1934  FOR THE TRANSITION PERIOD FROM   ____________  
       TO _____________.


                         Commission File Number: 0-20199

                              EXPRESS SCRIPTS, INC.
             (Exact name of registrant as specified in its charter)

             DELAWARE                                          43-1420563
  (State or other jurisdiction                  (I.R.S. employer identification
   of incorporation or organization)                   no.)

14000 RIVERPORT DR., MARYLAND HEIGHTS, MISSOURI                   63043
     (Address of principal executive offices)                   (Zip Code)


       Registrant's telephone number, including area code: (314) 770-1666

           Securities registered pursuant to Section 12(b) of the Act:

                                      None

           Securities registered pursuant to Section 12(g) of the Act:

                      CLASS A COMMON STOCK, $0.01 PAR VALUE
                                (Title of Class)

     Indicate  by check mark  whether the  registrant  (1) has filed all reports
required to be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of
1934  during  the  preceding  12 months  (or for such  shorter  period  that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days. Yes X No ---

     Indicate by check mark if disclosure of delinquent  filers pursuant to Item
405 of Regulation of S-K is not contained herein, and will not be contained,  to
the  best  of  Registrant's   knowledge,  in  definitive  proxy  or  information
statements  incorporated  by  reference  in Part  III of this  Form  10-K or any
amendment to this Form 10-K. [X]

     The  aggregate   market  value  of   Registrant's   voting  stock  held  by
non-affiliates as of March 1, 1999, was $1,207,562,195  based on 18,158,830 such
shares held on such date by non-affiliates and the last sale price for the Class
A Common Stock on such date of $66.50 as reported on the Nasdaq National Market.
Solely for purposes of this  computation,  the  Registrant  has assumed that all
directors  and  executive  officers  of the  Registrant  and  NYLIFE  HealthCare
Management, Inc. are affiliates of the Registrant.

Common stock outstanding as of March 1, 1999:   18,206,130  Shares Class A
                                                15,020,000  Shares Class B

                       DOCUMENTS INCORPORATED BY REFERENCE

     Part  III  incorporates  by  reference  portions  of the  definitive  proxy
statement for the  Registrant's  1999 Annual Meeting of  Stockholders,  which is
expected to be filed with the Securities and Exchange  Commission not later than
120  days  after  the   registrant's   fiscal  year  ended  December  31,  1998.


                                     PART I

                                   THE COMPANY

FORWARD LOOKING STATEMENTS AND ASSOCIATED RISKS

     INFORMATION  THAT WE HAVE  INCLUDED OR  INCORPORATED  BY  REFERENCE IN THIS
ANNUAL REPORT ON FORM 10-K, AND  INFORMATION  THAT MAY BE CONTAINED IN OUR OTHER
FILINGS WITH THE  SECURITIES AND EXCHANGE  COMMISSION  (THE "SEC") AND OUR PRESS
RELEASES OR OTHER  PUBLIC  STATEMENTS,  CONTAIN OR MAY  CONTAIN  FORWARD-LOOKING
STATEMENTS.  THESE FORWARD LOOKING STATEMENTS INCLUDE, AMONG OTHERS,  STATEMENTS
OF OUR PLANS, OBJECTIVES,  EXPECTATIONS OR INTENTIONS, INCLUDING AS TO YEAR 2000
ISSUES.

     OUR FORWARD-LOOKING STATEMENTS INVOLVE RISKS AND UNCERTAINTIES.  OUR ACTUAL
RESULTS  MAY DIFFER  SIGNIFICANTLY  FROM THOSE  PROJECTED  OR  SUGGESTED  IN ANY
FORWARD-LOOKING  STATEMENTS.  WE DO NOT  UNDERTAKE  ANY  OBLIGATION  TO  RELEASE
PUBLICLY ANY REVISIONS TO SUCH  FORWARD-LOOKING  STATEMENTS TO REFLECT EVENTS OR
CIRCUMSTANCES  OCCURRING  AFTER THE DATE HEREOF OR TO REFLECT THE  OCCURRENCE OF
UNANTICIPATED  EVENTS.  FACTORS  THAT  MIGHT  CAUSE SUCH A  DIFFERENCE  TO OCCUR
INCLUDE, BUT ARE NOT LIMITED TO:

     -RISKS  ASSOCIATED  WITH THE  CONSUMMATION OF  ACQUISITIONS,  INCLUDING THE
ABILITY TO SUCCESSFULLY INTEGRATE THE OPERATIONS OF ACQUIRED BUSINESSES WITH OUR
EXISTING OPERATIONS, CLIENT RETENTION ISSUES, AND RISKS INHERENT IN THE ACQUIRED
ENTITIES OPERATIONS

     -RISKS  ASSOCIATED  WITH OBTAINING  FINANCING AND CAPITAL 

     -RISKS  ASSOCIATED WITH OUR ABILITY TO MANAGE  GROWTH  COMPETITION

     -INCLUDING  PRICE  COMPETITION,  COMPETITION  IN THE BIDDING  AND  PROPOSAL
PROCESS AND OUR ABILITY TO CONSUMMATE  CONTRACT  NEGOTIATIONS  WITH  PROSPECTIVE
CLIENTS

     -THE  POSSIBLE  TERMINATION  OF  CONTRACTS  WITH  CERTAIN  KEY  CLIENTS  OR
PROVIDERS

     -THE POSSIBLE  TERMINATION OF CONTRACTS WITH CERTAIN KEY MANUFACTURERS,  OR
CHANGES  IN  PRICING,  DISCOUNT,  REBATE OR OTHER  PRACTICES  OF  PHARMACEUTICAL
MANUFACTURERS

     -ADVERSE RESULTS IN LITIGATION

     -ADVERSE RESULTS IN REGULATORY MATTERS, THE ADOPTION OF ADVERSE LEGISLATION
OR  REGULATIONS,   MORE  AGGRESSIVE   ENFORCEMENT  OF  EXISTING  LEGISLATION  OR
REGULATIONS,  OR A CHANGE  IN THE  INTERPRETATION  OF  EXISTING  LEGISLATION  OR
REGULATIONS

     -DEVELOPMENTS  IN  THE  HEALTH  CARE  INDUSTRY,  INCLUDING  THE  IMPACT  OF
INCREASES  IN HEALTH  CARE  COSTS,  CHANGES  IN DRUG  UTILIZATION  PATTERNS  AND
INTRODUCTIONS OF NEW DRUGS

     -RISKS ASSOCIATED WITH THE "YEAR 2000" ISSUE

     -DEPENDENCE ON KEY MEMBERS OF MANAGEMENT

     -OUR  RELATIONSHIP  WITH NEW YORK LIFE INSURANCE  COMPANY,  WHICH POSSESSES
VOTING CONTROL OF THE COMPANY

     -OTHER RISKS DESCRIBED FROM TIME TO TIME IN OUR FILINGS WITH THE SEC

     THESE AND OTHER RELEVANT FACTORS,  INCLUDING ANY OTHER INFORMATION INCLUDED
OR  INCORPORATED  BY  REFERENCE  IN THIS  REPORT,  AND  INFORMATION  THAT MAY BE
CONTAINED IN OUR OTHER FILINGS WITH THE SEC, SHOULD BE CAREFULLY CONSIDERED WHEN
REVIEWING ANY FORWARD-LOOKING  STATEMENT. THE OCCURRENCE OF ANY OF THE FOLLOWING
RISKS COULD MATERIALLY ADVERSELY AFFECT OUR BUSINESS,  RESULTS OF OPERATIONS AND
FINANCIAL CONDITION.

FAILURE TO INTEGRATE VALUERX AND DPS COULD ADVERSELY AFFECT OUR BUSINESS

     On April 1, 1998,  we completed  our first major  acquisition  by acquiring
ValueRx,  the  pharmacy  benefit  management  ("PBM")  business of  Columbia/HCA
Healthcare Corporation, for approximately $460 million in cash. This transaction
significantly   increased  our  membership   base  and  the  complexity  of  our
operations. In the second quarter of 1999, we expect to complete our acquisition
of Diversified  Pharmaceutical  Services,  Inc. and  Diversified  Pharmaceutical
Services  (Puerto Rico),  Inc.  (collectively,  "DPS") from  SmithKline  Beecham
Corporation and one of its affiliates for $700 million in cash.  Consummation of
the  transaction  is  subject to  customary  closing  conditions,  and we cannot
provide any assurance that all such  conditions  will be satisfied such that the
transaction  may  be  consummated.   If   consummated,   the  transaction   will
approximately  double our membership base and further increase the complexity of
our  operations.  In light of both  acquisitions,  we have developed and, in the
case of ValueRx,  begun to implement,  an integration plan to address items such
as:

     -retention of key employees
     -consolidation of administrative and other duplicative functions 
     -coordination of sales, marketing, customerservice and clinical functions 
     -systems integration 
     -new product and service development 
     -client retention and other items

     While we have achieved many of our  integration  goals to date with respect
to the  acquisition  of  ValueRx,  certain  significant  integration  challenges
remain,  including  the  complete  integration  of  our  information  technology
systems.  We  cannot  provide  any  assurance  that our  integration  plan  will
successfully address all aspects of our operations,  or that we will continue to
achieve  our  integration  goals.  In the case of DPS,  we  cannot  provide  any
assurance that our integration  plan will address all relevant  aspects of DPS's
business or that we will be able to implement our integration plan successfully.
In addition,  we assumed a certain  level of client  retention  when deciding to
purchase ValueRx and DPS. Many clients have relatively short-term contracts, and
we cannot  provide  any  assurance  that we will be able to  achieve  our client
retention targets.  Finally, although we conducted an extensive investigation in
evaluating our acquisitions of ValueRx and DPS, it is possible that we failed to
uncover or  appropriately  address  material  problems  with  ValueRx's or DPS's
operations or financial condition, or failed to discover contingent liabilities.
Any of the foregoing could materially adversely affect our results of operations
or financial condition.

FAILURE TO OBTAIN FINANCING OR CAPITAL COULD ADVERSELY AFFECT OUR BUSINESS

     Our ability to consummate  the DPS  transaction  is dependent  upon,  among
other things, our securing  financing of approximately $1.1 billion,  consisting
of an $800  million  term loan  facility  and a $300  million  revolving  credit
facility,  for which we have  obtained a  commitment  from Credit  Suisse  First
Boston  ("CSFB").  This new credit  facility is intended to replace our existing
$440 million  facility with Bankers Trust  Company.  The commitment for this new
facility  is,  however,  subject to  various  conditions,  which we believe  are
customary for  transactions  of this kind,  but we cannot  provide any assurance
that all such  conditions  will be satisfied so that this credit facility can be
funded.  We have also obtained a commitment  from CSFB for a $150 million bridge
loan which may be needed to  facilitate  the  closing of the  acquisition.  This
commitment  is also subject to various  conditions,  which we again  believe are
customary  for  transactions  of this  kind.  However,  we  cannot  provide  any
assurance  that all such  conditions  will be satisfied so that this bridge loan
facility will be funded.

     We have  recently  filed  a  registration  statement,  which  has not  been
declared   effective,   with  the  SEC  for  a  proposed   primary  offering  of
approximately  $350  million  of  Class A Common  Stock.  The  proceeds  of this
offering,  which  will be made only by means of a  prospectus,  would be used to
retire the bridge loan, if funded,  and repay a portion of the debt  outstanding
under the new  credit  facility,  assuming  it is also  funded.  Our  ability to
complete the stock offering is subject to investors' willingness to purchase the
shares and other typical market risks,  which we cannot control,  as well as the
success of the Company. We cannot, therefore, provide any assurance that we will
be able to successfully  complete this offering,  and if we fail to complete the
offering as planned,  our financial condition and future operating results could
be materially  adversely affected.  Again, a registration  statement relating to
these securities has been filed with the Securities and Exchange  Commission but
has not yet become effective. These securities may not be sold nor may offers to
buy be accepted prior to the time the registration  statement becomes effective.
This Report  shall not  constitute  an offer to sell or the  solicitation  of an
offer to buy nor  shall  there be any sale of these  securities  in any state in
which such offer,  solicitation  or sale would be unlawful prior to registration
or  qualification  under  the  securities  laws  of any  such  state.  Once  the
registration  statement has been declared  effective,  a prospectus  meeting the
requirements  of Section 10 of the Securities  Exchange Act of 1933, as amended,
may be obtained by contacting Thomas M. Boudreau,  Esq., Express Scripts,  Inc.,
14000 Riverport Drive, Maryland Heights, Missouri 63043.

FAILURE TO MANAGE AND MAINTAIN INTERNAL GROWTH COULD ADVERSELY AFFECT OUR 
BUSINESS

     We have experienced  rapid internal growth over the past several years. Our
ability to  effectively  manage and maintain this  internal  growth will require
that we continue to improve our financial and management  information systems as
well as identify and retain key  personnel.  We can provide no assurance that we
will  successfully  meet  these  requirements  or that we will  have  access  to
sufficient  capital to do so. Our  internal  growth is also  dependent  upon our
ability to attract new clients and achieve growth in the membership  base of our
existing clients. If we are unable to continue our client and membership growth,
our results of operations and financial  position could be materially  adversely
affected.

THE PBM INDUSTRY IS VERY COMPETITIVE

     Pharmacy benefit management is a very competitive business. Our competitors
include  several  large and  well-established  companies  which may have greater
financial,   marketing  and  technological  resources  than  we  do.  One  major
competitor in the PBM business,  Merck-Medco  Managed Care,  L.L.C., is owned by
Merck  &  Co.,  Inc.,  a  large  pharmaceutical   manufacturer.   Another  major
competitor, PCS, Inc., is owned by Rite-Aid Corporation, a large retail pharmacy
chain. Both of these competitors may possess purchasing or other advantages over
us by virtue of their ownership. Consolidation in the PBM industry may also lead
to  increased  competition  among a  smaller  number  of  large  PBM  companies.
Competition  may also come from other  sources  in the  future,  including  from
Internet-based  providers such as Drugstore.com.  We cannot predict what effect,
if any, these new competitors may have on the marketplace or on our business.

     Over the last several  years intense  competition  in the  marketplace  has
caused many PBMs, including us, to reduce the prices charged to clients for core
services and share a larger portion of the formulary  fees and related  revenues
received from drug manufacturers with clients. This combination of lower pricing
and increased  revenue sharing has caused our operating  margins to decline (see
"Management's  Discussion  and  Analysis of Financial  Condition  and Results of
Operations").  We expect to continue  marketing our services to larger  clients,
who typically have greater  bargaining  power than smaller  clients.  This might
create  continuing  pressure on our margins.  We can give no assurance  that new
services  provided to these  clients  will fully  compensate  for these  reduced
margins.

FAILURE TO RETAIN KEY CLIENTS AND NETWORK PHARMACIES COULD ADVERSELY AFFECT 
                                  OUR BUSINESS

     We  currently  provide PBM services to  approximately  8,500  clients.  Our
acquisitions  have diversified our client base and reduced our dependence on any
single client.  After giving effect to the pending DPS  acquisition,  our top 10
clients,  measured  as of January  1,  1999,  but  excluding  United  HealthCare
Corporation,  represent  approximately  27% of our total membership base, but no
single  client  would,  on a  combined  pro  forma  basis,  represent  more than
approximately 6% of our membership base. Our contracts with clients generally do
not have terms of longer  than three years and in some cases are  terminable  by
either party on relatively short notice. Our larger clients generally distribute
requests for  proposals and seek bids from other PBM providers in advance of the
expiration  of their  contracts.  If several of these large clients elect not to
extend their relationship with us, and we are not successful in generating sales
to replace the lost business, our future business and operating results could be
materially adversely affected. In addition, we believe the managed care industry
is undergoing  substantial  consolidation,  and some of our managed care clients
could be acquired by another  party that is not our  client.  In such case,  the
likelihood such client would renew its PBM contract with us could be reduced.

     Assuming  consummation of the pending DPS  acquisition,  United  HealthCare
Corporation will be our largest client, with approximately 10.5 million members.
DPS's  contract with United  HealthCare  will expire on May 24, 2000, and United
HealthCare has indicated it will be moving to another  provider at that time. In
our financial  analysis of the DPS  acquisition,  we assumed  United  HealthCare
would not renew its  contract.  However,  the  termination  of this contract may
still materially adversely affect our business and results of operations.

     Our largest  national  provider network consists of more than 52,000 retail
pharmacies, which represent more than 99% of the retail pharmacies in the United
States.  However, the top 10 retail pharmacy chains represent  approximately 41%
of the 52,000  pharmacies,  with these pharmacy chains  representing even higher
concentrations in certain areas of the United States.  Our contracts with retail
pharmacies are generally  terminable by either party on relatively short notice.
If one or more of the top pharmacy  chains elects to terminate its  relationship
with us, our  business  could be  materially  adversely  affected.  In addition,
Rite-Aid  Corporation  recently acquired one of our major PBM competitors,  PCS,
Inc.  Other  large  pharmacy  chains  either own PBMs today or could  attempt to
acquire a PBM in the future.  Ownership of PBMs by retail  pharmacy chains could
have material adverse effects on our relationships with such pharmacy chains and
on our business and results of operations.

LOSS OF CERTAIN RELATIONSHIPS WITH PHARMACEUTICAL MANUFACTURERS COULD ADVERSELY
                               AFFECT OUR BUSINESS

     We  maintain   contractual   relationships  with  numerous   pharmaceutical
manufacturers  which provide us with  discounts,  rebates or formulary  fees. We
also  provide   various   services  for,  or  services   which  are  funded  by,
pharmaceutical  manufacturers.   These  services  include  compliance,   therapy
management  and market  research  programs.  These  arrangements  are  generally
terminable  by either  party on  relatively  short  notice.  If several of these
arrangements  are  terminated  or  materially   altered  by  the  pharmaceutical
manufacturers, our business could be materially adversely affected. In addition,
discounts,  rebates and formulary  programs,  as well as some of the services we
provide to the pharmaceutical manufacturers,  have been the subject of debate in
federal  and state  legislatures  and various  other  public  forums.  We cannot
predict the effect of any changes in existing  laws or  regulations  or in their
interpretations,   or  the  adoption  of  new  laws  or   regulations,   on  our
relationships with pharmaceutical manufacturers.

     Patents  covering  many brand name drugs that  currently  have  substantial
market share will expire over the next several years,  and generic drugs will be
introduced  at prices that may  substantially  reduce the market  share of these
brand name drugs. Unlike brand name drug manufacturers, manufacturers of generic
drugs do not generally  offer  incentive  payments on their drugs to PBMs in the
form of discounts,  rebates or formulary  fees and programs.  Although we expect
new drugs with patent  protection to be introduced in the future, we can provide
no assurance such drugs will capture a significant share of the market such that
our incentive payment revenues will not be reduced.

OUR BUSINESS MAY BE ADVERSELY AFFECTED BY LITIGATION

     Since 1993, retail pharmacies have filed over 100 separate lawsuits against
drug  manufacturers,  wholesalers and certain PBMs,  challenging brand name drug
pricing practices under various state and federal antitrust laws. The plaintiffs
alleged,  among other things,  that the manufacturers  had offered,  and certain
PBMs had  knowingly  accepted,  discounts and rebates on purchases of brand name
prescription  drugs  that  violated  the  federal  Sherman  Act and the  federal
Robinson-Patman  Act. Some drug manufacturers  settled certain of these actions,
including a Sherman Act case brought on behalf of a  nationwide  class of retail
pharmacies.  The class action settlements  generally provided for commitments by
the manufacturers in their discounting practices to retail pharmacies. The class
action was recently  dismissed as to drug  manufacturers and wholesalers who did
not settle.  With respect to the cases filed by plaintiffs  who opted out of the
class  action,  while  some drug  manufacturers  have  settled  certain of these
actions, such settlements are not part of the public record.

     Neither we nor DPS is  currently  a party to any of these  proceedings.  To
date,  we do not believe any of these  settlements  have had a material  adverse
effect on our business.  However, we cannot provide any assurance that the terms
of the settlements will not materially adversely affect us in the future or that
we will not be made a party to any  separate  lawsuit.  In  addition,  we cannot
predict the outcome or possible  ramifications  to our  business of the cases in
which the plaintiffs are trying their claims separately.

     We are also  subject to risks  relating to  litigation  and  liability  for
damages in  connection  with our PBM  operations,  including  the  dispensing of
pharmaceutical  products  by our  mail  pharmacies,  the  services  rendered  in
connection  with our  formulary  management  and  informed  decision  counseling
services,  and our non-PBM  operations,  including  the  products  and  services
provided in connection  with our infusion  therapy  programs (and the associated
nursing  services).  We believe our  insurance  protection  is adequate  for our
present  operations.  However,  we cannot  provide any assurance that we will be
able to maintain our professional and general  liability  insurance  coverage in
the future or that such insurance coverage will be available on acceptable terms
to cover any or all  potential  product  or  professional  liability  claims.  A
successful  product or  professional  liability claim in excess of our insurance
coverage could have a material adverse effect on our business.

STATE AND FEDERAL REGULATIONS COULD ADVERSELY AFFECT OUR BUSINESS

     Numerous  state and federal  laws and  regulations  affect our business and
operations. The categories include, but are not necessarily limited to:

     -anti-remuneration laws
     -the Employee Retirement Income Security Act and related regulations
     -proposed comprehensive state PBM legislation
     -consumer protection laws 
     -network access (i.e.,"any willing provider" and "due process" legislation)
     -legislation imposing benefit plan design restrictions
     -licensure laws
     -drug pricing legislation (i.e., "mostfavored nation" pricing and 
          "unitary pricing" legislation)
     -mail pharmacy regulations
     -privacy and confidentiality legislation
     -Medicare and Medicaid reimbursement regulations
     -potential regulation of the PBM industry by the U.S. Food and Drug 
          Administration

These and other regulatory matters are discussed in more detail under "Business
- - Government Regulation" below.

     We  believe  we are in  substantial  compliance  with  all  existing  legal
requirements  material to the  operation of our  business.  There are,  however,
significant  uncertainties  involving  the  application  of many of these  legal
requirements to our business.  In addition,  there are numerous  proposed health
care laws and  regulations at the federal and state levels,  many of which could
materially  adversely  affect  our  business.  We are  unable  to  predict  what
additional federal or state legislation or regulatory initiatives may be enacted
in the future  relating to our business or the health care  industry in general.
We also cannot predict what effect any such  legislation  or  regulations  might
have  on us.  We also  cannot  provide  any  assurance  that  federal  or  state
governments will not impose additional  restrictions or adopt interpretations of
existing  laws that could  have a material  adverse  effect on our  business  or
results of operations.

CHANGES IN THE HEALTH CARE INDUSTRY COULD ADVERSELY AFFECT OUR BUSINESS

     Efforts are being made in the United  States to control  health care costs,
including prescription drug costs, in response to, among other things, increases
in prescription  drug  utilization  rates and drug prices.  If these efforts are
successful  or  if  prescription   drug  utilization   rates  were  to  decrease
significantly,  our  business  and  results of  operations  could be  materially
adversely affected.

     We have  designed our business to compete  within the current  structure of
the U.S.  health  care  system.  Changing  political,  economic  and  regulatory
influences may affect health care financing and reimbursement  practices. If the
current health care financing and  reimbursement  system changes  significantly,
our  business  could be  materially  adversely  affected.  Congress is currently
considering proposals to reform the U.S. health care system. These proposals may
increase governmental involvement in health care and PBM services, and otherwise
change the way our clients do business.  Health care  organizations may react to
these  proposals and the  uncertainty  surrounding  them by reducing or delaying
purchases of cost control  mechanisms and related  services that we provide.  We
cannot predict what effect,  if any,  these  proposals may have on our business.
Other  legislative  or  market-driven  changes in the health care system that we
cannot anticipate could also materially adversely affect our business.

FAILURE TO ADDRESS THE YEAR 2000 ISSUE COULD ADVERSELY AFFECT OUR BUSINESS

     Our business  relies  heavily on computers  and other  information  systems
technology.  In 1995, we began addressing the "Year 2000" issue, which generally
refers to the  inability  of  certain  computer  systems to  properly  recognize
calendar  dates beyond  December 31, 1999.  We developed a Year 2000  compliance
plan to address:

     -internally  developed  application  software 
     -vendor  developed  applications software
     -operating   system   software
     -utility   software
     -vendor/trading partner-supplied files
     -externally provided data or transactions
     -non-informationt technology devices
     -adherence to applicable industry standards

See "Management's Discussion and Analysis of Financial Conditions and Results of
Operations" for additional information on our Year 2000 efforts.

     We believe that with  appropriate  modifications  to our existing  computer
systems,  updates by our vendors  and trading  partners  and  conversion  to new
software in the ordinary  course of our  business,  the Year 2000 issue will not
pose material  operational  problems for us. However, if the conversions are not
completed in a proper and timely manner by all affected parties, or if our logic
for communicating with noncompliant systems is ineffective,  the Year 2000 issue
could result in material adverse  operational and financial  consequences to us.
We cannot  provide any assurance  that our efforts,  or those of our vendors and
trading partners (who are beyond our control),  will be successful in addressing
the Year 2000 issue.  In addition,  while DPS has  represented to us that it has
implemented a Year 2000 plan for upgrading its computer systems and communicated
with its vendor/trading  partners regarding such partners' Year 2000 compliance,
we cannot predict  whether such plan will  adequately  address all of DPS's Year
2000 issues or whether DPS's  vendors/trading  partners will adequately  address
their Year 2000  issues.  Failure  by DPS and its  vendors/trading  partners  to
adequately  address the Year 2000 issue could have a material  adverse effect on
our business and results of  operations.  We also cannot  provide any  assurance
that our  contingency  plan,  or that of DPS,  will be complete  and  adequately
address all possible contingencies. The failure of our contingency plan, or that
of DPS, could result in material adverse operational and financial  consequences
to us.

LOSS OF KEY MANAGEMENT COULD ADVERSELY AFFECT OUR BUSINESS

     Our success is  materially  dependent  upon  certain key  managers  and, in
particular,  upon the continued  services of Barrett A. Toan,  our President and
Chief Executive  Officer.  Our future  operations could be materially  adversely
affected if the services of Mr. Toan cease to be available.  The Company and Mr.
Toan are parties to an employment  agreement which currently extends to April 1,
2000, and which automatically  extends for an additional two years on each April
1, unless either party gives notice of termination prior to the April 1 date. As
of the date hereof, neither we nor Mr. Toan has given such notice.

NEW YORK LIFE INSURANCE COMPANY CAN EXERCISE SIGNIFICANT CONTROL OVER OUR 
BUSINESS

     We have two classes of authorized  common  stock:  Class A Common Stock and
Class B Common Stock.  Our Class A Common Stock has been publicly  traded on The
Nasdaq  National Market since June 9, 1992. Our Class B Common Stock is entirely
owned by NYLIFE HealthCare Management,  Inc. ("NYLIFE HealthCare"),  an indirect
subsidiary of New York Life Insurance  Company ("New York Life").  Each share of
our Class A Common  Stock has one vote per share,  and each share of our Class B
Common stock has ten votes per share.  Consequently,  although NYLIFE HealthCare
currently owns  approximately 45% of the Company's total  outstanding  shares of
Common Stock,  it possesses  approximately  89% of the combined  voting power of
both classes of Common Stock.  NYLIFE HealthCare could reduce its Class B Common
Stock  ownership to represent  slightly  less than 10% of the total  outstanding
shares of our common  stock and still  control a majority of the voting power of
our  common  stock.  Accordingly,  without  regard  to the  votes of our  public
stockholders, NYLIFE HealthCare can

     -elect or remove all of our directors
     -amend our certificate of incorporation, except where the separate 
          approval of the holders of our Class A Common Stock is required 
          by law
     -accept or reject a merger, sale of assets or other major corporate 
          transaction 
     -accept or reject any proposed acquisition of the Company 
     -determine the amount and timing of dividends paid to itself and holders 
          of our Class A Common Stock
     -except as described below, otherwise control our management and 
           operations and decide all matters submitted for a stockholder vote

     Our by-laws require that any material  transaction  with a related party be
approved  by the Audit  Committee  of our Board of  Directors,  which  currently
consists of three directors. A by-law provision, which cannot be changed without
the  affirmative  vote of a majority  of the  outstanding  shares of our Class A
Common Stock,  requires  that a majority of directors on the Audit  Committee be
persons who are not directors of New York Life or its  subsidiaries  (other than
us) or officers or  employees of New York Life or its  subsidiaries  (other than
us). A material  transaction is a transaction that, by itself, would be required
to be disclosed  in our proxy  statement.  The terms of the  original  contracts
between us and New York Life and its  subsidiaries  were not negotiated at arm's
length and were not approved by the Audit Committee, but all amendments to these
original  contracts  with New York Life and its  subsidiaries  subsequent to our
initial public  offering in 1992 have been approved by the Audit  Committee.  On
July  15,  1998,  New  York  Life  sold  substantially  all of its  health  care
businesses  (other  than its  interest  in us) to  Aetna  U.S.  Healthcare  Inc.
Consequently,  we do not  anticipate  entering  into any  material  PBM or other
health care service agreements with New York Life.

     New York Life has agreed  that so long as it,  directly  or through  one or
more of its majority  owned  subsidiaries,  owns 10% or more of our  outstanding
shares  of Class B Common  Stock,  New York Life will not  engage,  directly  or
through any of its  majority  owned  subsidiaries,  in a business  that  derives
substantial  revenues  from one or more of the following  activities  within the
United States (the "Protected Business"):

     -the providing of PBM services (including dispensing
         prescription drugs, monitoring cost and quality of
         pharmacy services, establishing a network of retail
         pharmacies, processing claims for prescription drugs,
         performing drug utilization review and assisting in the
         design of prescription drug programs for benefit plans)
     -the providing of vision care
     -the providing of infusion therapy services

However, New York Life and its majority owned subsidiaries may engage in the
following Protected Business activities:

     -portfolio investment activities, without any of the entities in which 
          they invest being subject to the foregoing restrictions
     -claims processing for prescription drugs in connection with processing 
          medical care claims under insurance policies
     -acquisition of entities engaged in all or any aspect of the Protected 
          Business, unless any such entity derived a  majority of its 
          consolidated revenues from the Protected Business in the fiscal year
          preceding such acquisition, and operation of the businesses of such
          acquired entities as they may thereafter develop or expand

     The above-mentioned  restrictions do not apply to any entities in which New
York Life and its subsidiaries own less than a majority equity interest.

     We cannot provide any assurance that any business opportunity that comes to
the attention of New York Life or its subsidiaries and affiliates and that falls
within the scope of the Protected  Business,  or might  otherwise be appropriate
for us to  consider  pursuing,  will be  directed  to us,  whether  or not  such
opportunity would be in our or our stockholders' best interest.

ITEM 1 - BUSINESS

INDUSTRY OVERVIEW

     Prescription  drug costs are the fastest  growing  component of health care
costs in the  United  States.  The U.S.  Health  Care  Financing  Administration
("HCFA") estimates that pharmaceuticals currently account for approximately 6.5%
of U.S.  health care  expenditures,  and are expected to increase to 8% by 2007.
Estimated U.S. pharmaceutical sales for 1998 were approximately $75 billion, and
HCFA  projects  continued  sales  increases at an average  annual growth rate of
approximately  10% through  2007,  compared to an average  annual growth rate of
approximately  7% for total  health  care  costs  during  this  period.  Factors
underlying  this trend  include:  (i)  increases  in  research  and  development
expenditures by drug  manufacturers,  resulting in many new drug  introductions,
(ii) a  shorter  U.S.  Food  and  Drug  Administration  approval  cycle  for new
pharmaceuticals,  (iii) high prices for new  "blockbuster"  drugs, (iv) an aging
population,  and (v) increased  demand for  prescription  drugs due to increased
disease awareness by patients, effective direct-to-consumer  advertising by drug
manufacturers and a growing reliance on medication in lieu of lifestyle changes.

     Health benefit  providers  have been seeking ways to better  understand and
control  drug  costs.   PBMs  help  health   benefit   providers  to  provide  a
cost-effective  drug benefit and to better understand the impact of prescription
drug  utilization  on  total  health  care  expenditures.  PBMs  coordinate  the
distribution   of   outpatient   pharmaceuticals   through  a   combination   of
benefit-management  services, including retail drug card programs, mail pharmacy
services and formulary management programs.

     PBMs emerged during the late 1980s by combining traditional pharmacy claims
processing and mail pharmacy  services to create an integrated  product offering
that could help manage the  prescription  drug  benefit  for payors.  During the
early  1990s,  numerous  PBMs were  created,  with  some  providers  offering  a
comprehensive, integrated package of services.

     The  services  offered by the more  sophisticated  PBMs have  broadened  to
include disease management  programs,  compliance  programs,  outcomes research,
drug therapy management programs and sophisticated data analysis. These advanced
capabilities require resources that may not be available to all PBMs, so further
industry  consolidation  may  occur.  If  prescription  drug costs  continue  to
escalate and become an even larger portion of overall health care  expenditures,
more advanced  capabilities  will be needed to manage these costs so that health
benefit providers will be able to continue to offer a quality  prescription drug
benefit to their  members.  The more  sophisticated  PBMs  should be in the best
position to offer these services.

COMPANY OVERVIEW

     We  are  the  largest   full-service  PBM  independent  of   pharmaceutical
manufacturer  or drug store  ownership in North  America.  PBMs  coordinate  the
distribution  of outpatient  pharmaceuticals  through a  combination  of benefit
management  services,   including  retail  drug  card  programs,  mail  pharmacy
services,  formulary management programs and other clinical management programs.
We provide these types of services for approximately  8,500 clients that include
HMOs, health insurers, third-party administrators, employers and union-sponsored
benefit plans.  We believe our  independence  from  pharmaceutical  manufacturer
ownership allows us to make unbiased  formulary  recommendations to our clients,
balancing both clinical efficacy and cost. We also believe our independence from
drug  store  ownership  allows us to  construct  a  variety  of  convenient  and
cost-effective  retail pharmacy  networks for our clients,  without favoring any
particular pharmacy chain.

     Before 1998,  our growth was driven  almost  exclusively  by our ability to
expand our product offerings and increase our client and membership base through
internally  generated  growth.  From 1992 through 1997, our net revenues and net
income  increased at compound annual growth rates of 58% and 49%,  respectively.
While our  internal  growth  strategy  remains a major focus,  we have  recently
complemented  our internal growth  strategy with two  substantial  acquisitions.
These  acquisitions  add to the scale of our  membership  base and  broaden  our
product  offerings.  In April 1998, we acquired  "ValueRx",  the PBM business of
Columbia/HCA Healthcare Corporation. In the second quarter of 1999, we expect to
complete  the  acquisition  of  DPS,  the PBM  business  of  SmithKline  Beecham
Corporation.  Upon  completion of our acquisition of DPS, we will continue to be
the third  largest PBM in North America in terms of total  members,  and we will
have one of the largest managed care membership bases of any PBM.

     As of January 1, 1999, our PBM services were provided to approximately 23.5
million  members in the United  States  and Canada who were  enrolled  in health
plans sponsored by our clients.  This total excludes members for whom we provide
only formulary management  services.  As of January 1, 1999, some of our largest
clients  were  Aetna  U.S.  Healthcare  and the  State of New York  Empire  Plan
Prescription Drug Program.

     Our PBM  services  are  primarily  delivered  through  networks  of  retail
pharmacies  that are under  contract  with us and  through  five  mail  pharmacy
service  centers that we own and operate.  Our largest retail  pharmacy  network
includes more than 52,000 retail  pharmacies,  representing more than 99% of all
retail  pharmacies in the United  States.  In 1998,  we processed  approximately
113.2   million   network   pharmacy   claims  and  7.4  million  mail  pharmacy
prescriptions,  with an  estimated  total drug  spending of  approximately  $4.5
billion.

     Our PBM services include:

     -network claims processing, mail pharmacy services, benefit
          design consultation, drug utilization review, formulary
          management programs, disease management and medical and drug
          data analysis services, and compliance and therapy management
          programs for our clients
     -market research programs for pharmaceutical manufacturers
     -medical information management services, which include provider profiling
          and outcome assessments, through our majority owned subsidiary 
          Practice Patterns Science, Inc. ("PPS")
     -informed decision counseling services through our Express Health LineSM
          division

     Our non-PBM services include:

     -infusion therapy services through our wholly owned subsidiary IVTx, Inc.
          ("IVTx")
     -distribution of pharmaceuticals requiring special handling or packaging 
          through our Specialty Distribution division

     Express  Scripts,  Inc. was incorporated in Missouri in September 1986, and
was  reincorporated  in Delaware  in March  1992.  We have two classes of common
stock,  Class A Common Stock and Class B Common Stock. Each share of the Class B
Common  Stock is  entitled  to ten  votes,  and each share of the Class A Common
Stock is entitled to one vote. All of the issued and  outstanding  shares of the
Class B Common Stock are owned by NYLIFE  HealthCare.  Our  principal  executive
offices are located at 14000 Riverport Drive, Maryland Heights,  Missouri 63043.
Our telephone number is (314) 770-1666.

PRODUCTS AND SERVICES

PHARMACY BENEFIT MANAGEMENT SERVICES

     OVERVIEW.   Our  PBM  services   involve  the   management   of  outpatient
prescription  drug usage to foster high quality,  cost-effective  pharmaceutical
care through the application of managed care principles and advanced information
technologies.  We offer our PBM services to our clients in the United States and
Canada.  PBM services  consist of retail pharmacy network  administration,  mail
pharmacy services,  benefit plan design consultation,  formulary administration,
electronic  point-of-sale claims processing and drug utilization review. Our PBM
services also include:  (i) the development of advanced formulary compliance and
therapeutic  intervention  programs;  (ii) therapy  management  services such as
prior  authorization,  therapy guidelines,  step therapy protocols and formulary
management  interventions;  (iii) sophisticated management information reporting
and analytic services; (iv) provider profiling and outcomes assessments; and (v)
informed decision counseling.

     During  1998,  97.9% of our net revenues  were  derived from PBM  services,
compared to 96.8% and 96.1%  during 1997 and 1996,  respectively.  The number of
retail pharmacy  network claims processed and mail pharmacy claims processed has
increased to 113.2 million and 7.4 million claims,  respectively,  in 1998, from
26.3  million and 1.6 million  claims,  respectively,  in 1994.  During 1997 and
1996, we processed 73.2 million and 57.8 million retail pharmacy network claims,
respectively,   and  3.9  million  and  2.8  million   mail   pharmacy   claims,
respectively.

     RETAIL PHARMACY NETWORK ADMINISTRATION.  We contract with retail pharmacies
to provide  prescription  drugs to members of the pharmacy benefit plans managed
by us. In the United States,  these pharmacies  typically  discount the price at
which they will provide drugs to members in return for  designation as a network
pharmacy.  We manage  four  nationwide  networks  in the  United  States and one
nationwide network in Canada that are responsive to client  preferences  related
to cost  containment  and  convenience  of access for  members.  We also  manage
networks of  pharmacies  that are under  direct  contract  with our managed care
clients or networks that we have designed to meet the specific  needs of some of
our larger clients.

     All retail pharmacies in our pharmacy networks  communicate with us on-line
and in real time to process  prescription  drug claims.  When a member of a plan
presents  his or her  identification  card at a network  pharmacy,  the  network
pharmacist sends the specified claim data in an industry-standard format through
our  systems,  which  process the claim and respond to the  pharmacy,  typically
within one or two seconds. The electronic processing of the claim involves:  (i)
confirming the member's  eligibility  for benefits  under the applicable  health
benefit plan and the  conditions  to or  limitations  of  coverage,  such as the
amount of  copayments  or  deductibles  the member must pay,  (ii)  performing a
concurrent drug utilization  review ("DUR") analysis and alerting the pharmacist
to possible drug interactions or other indications of inappropriate prescription
drug usage, (iii) updating the member's prescription drug claim record, and (iv)
if the  claim is  accepted,  confirming  to the  pharmacy  that it will  receive
payment for the drug dispensed.

     MAIL PHARMACY SERVICES.  We integrate our retail pharmacy services with our
mail pharmacy  services.  We operate five mail  pharmacies,  located in Maryland
Heights,   Missouri;   Tempe,  Arizona;   Albuquerque,   New  Mexico;  Bensalem,
Pennsylvania;  and  Troy,  New  York.  These  pharmacies  provide  members  with
convenient  access to maintenance  medications  and enable us and our clients to
control drug costs through  operating  efficiencies  and economies of scale.  In
addition, through our mail service pharmacies, we are directly involved with the
prescriber  and  member,  and are  generally  able to achieve a higher  level of
generic substitutions and therapeutic interventions than can be achieved through
the retail pharmacy networks. This further reduces our clients' costs.

     BENEFIT PLAN DESIGN AND CONSULTATION  SERVICES.  We offer  consultation and
financial  modeling  services to assist the client in  selecting a benefit  plan
design that meets its needs for member  satisfaction and cost control.  The most
common  benefit  design  options  we offer to our  clients  are:  (i)  financial
incentives  and  reimbursement  limitations  on the drugs  covered  by the plan,
including  drug  formularies,  flat dollar or  percentage of  prescription  cost
copayments,   deductibles   or  annual  benefit   maximum,   (ii)  generic  drug
substitution  incentives,  (iii)  incentives or requirements to use only network
pharmacies  or to  order  certain  drugs  only by mail,  and (iv)  reimbursement
limitations  on the number of days' supply of a drug that can be  obtained.  The
selected benefit design is entered into our electronic claims processing system,
which applies the plan design  parameters as claims are submitted and enables us
and our clients to monitor the financial performance of the plan.

     ADVANCED FORMULARY COMPLIANCE AND THERAPY MANAGEMENT  SERVICES.  We provide
advanced formulary compliance services to our clients.  Formularies are lists of
drugs for which coverage is provided under the applicable  plan. They are widely
used in managed  health  care  plans and,  increasingly,  by other  health  plan
managers.  We administer a number of different  formularies for our clients that
often  identify  preferred  drugs whose use is  encouraged  or required  through
various benefit design features. Historically, many clients have selected a plan
design  which  includes an open  formulary in which all drugs are covered by the
plan and preferred drugs, if any, are merely recommended.  More advanced options
consist  of  restricted  formularies,   in  which  various  financial  or  other
incentives  exist for the selection of preferred drugs over their  non-preferred
counterparts,  or closed  formularies,  in which benefits are available only for
drugs listed on the formulary.  Formulary preferences can be encouraged:  (i) by
restricting  the  formulary  through  plan  design  features,   such  as  tiered
copayments,  which require the member to pay a higher amount for a non-preferred
drug, (ii) through  prescriber  education  programs,  in which we or the managed
care  client  actively  seek to  educate  the  prescribers  about the  formulary
preferences,  and (iii) through our OptiMedSM drug therapy  management  program,
which actively  promotes  therapeutic  and generic  interchanges  to reduce drug
costs.  We  also  offer  the   ExpressTherapeutics(R)   program,  an  innovative
proprietary drug utilization review and clinical intervention program, to assist
clients  in  managing   compliance   with  the   prescribed   drug  therapy  and
inappropriate prescribing practices. Although we derive substantial revenue from
pharmaceutical manufacturers,  we recognize our primary responsibility is to the
plan   sponsors,   and  we  believe  our  contracts   with  the   pharmaceutical
manufacturers  provide  us the  flexibility  to  utilize  the  most  efficacious
products.

     Our National Pharmacy and Therapeutics  Committee,  composed of independent
physicians and pharmacists,  evaluates drugs within a therapy class to determine
whether it is clinically  appropriate to give  formulary  preference to one drug
over another.  If clinical  appropriateness  is established  to the  committee's
satisfaction,  it then evaluates the  cost-effectiveness of drugs in the therapy
class. Once a client adopts a formulary, we administer the formulary through our
electronic  claims  processing  system,  which  alerts  the  pharmacist  if  the
prescriber has not prescribed the preferred  drug. We or the pharmacist can then
contact the prescriber to attempt to obtain the  prescriber's  consent to switch
the prescription to the preferred product.

     INFORMATION REPORTING AND ANALYSIS AND DISEASE MANAGEMENT PROGRAMS. Through
the  development  of  increasingly   sophisticated  management  information  and
reporting  systems,  we  believe  we  manage  prescription  drug  benefits  more
effectively.  We have  developed  various  services  to offer our  clients.  One
service  enables a client to analyze  prescription  drug data to  identify  cost
trends and budget for expected  drug costs,  to assess the  financial  impact of
plan design  changes  and to identify  costly  utilization  patterns  through an
on-line  prescription  drug  decision  support tool called  RxWorkbenchTM.  This
service  permits  our  clients'  medically  sophisticated  personnel,  such as a
clinical  pharmacist  employed  by an HMO,  to  analyze  prescription  drug data
on-line.

     In  addition,  our  PPS  subsidiary  offers  provider  profiling,   disease
management  support  services  and  outcomes  assessments,   and  has  developed
proprietary  software  to process and sort  medical  claims,  prescription  drug
claims  and  clinical  laboratory  data.  This  data  is then  used  to  produce
comprehensive  information  about  treatment  of  patients  that  can be used by
managed care organizations and other companies involved in formulary  management
programs to treat a particular disease in a quality,  cost-effective manner. The
patient-specific  data  generated  through  all of  these  services  can then be
compared  to data in  PPS's  normative  databases,  and  PPS can  determine  the
effectiveness  of treatment  and  calculate  the total costs of that  treatment,
including the prescription  drug component.  The information can also be used to
analyze the practice  patterns of health care providers and develop  empirically
based "best practice" protocols, which recommend treatment regimens for specific
diseases.

     We offer additional  disease  management  programs to assist health benefit
plans in managing the total health care costs associated with certain  diseases,
such as asthma,  diabetes and cardiovascular  disease.  These programs are based
upon the premise  that patient and provider  behavior can  positively  influence
medical outcomes and reduce overall medical costs. Patient identification can be
accomplished   through  claims  data  analysis  or  self-enrollment,   and  risk
stratification  surveys are conducted to establish a plan of care for individual
program  participants.  Patient education is primarily effected through a series
of telephone and written  communications  with nurses and pharmacists,  and both
providers and patients  receive  progress  reports on a regular  basis.  Outcome
surveys are conducted and results are compiled to analyze the clinical, personal
and economic impact of the program.

     ELECTRONIC  CLAIMS  PROCESSING  SYSTEM.  Our electronic  claims  processing
system enables us to implement sophisticated  intervention programs to assist in
managing  prescription  drug  utilization.  The  system can be used to alert the
pharmacist to generic  substitution and therapeutic  intervention  opportunities
and formulary  compliance  issues,  or to  administer  prior  authorization  and
step-therapy  protocol programs at the time a claim is submitted for processing.
Our  claims  processing  system  also  creates a  database  of drug  utilization
information  that can be accessed both at the time the prescription is dispensed
and also on a retrospective  basis to analyze utilization trends and prescribing
patterns for more intensive management of the drug benefit.

     INFORMED  DECISION  COUNSELING  SERVICES.  We offer  health  care  decision
counseling  services  through our Express Health LineSM  division.  This service
allows a member to call a toll-free  telephone  number and discuss a health care
matter with a care counselor who utilizes on-line decision support protocols and
other  guidelines  to  provide  information  to assist  the  member in making an
informed  decision in seeking  appropriate  treatment.  Records of each call are
maintained  on-line for future  reference.  The service is  available 24 hours a
day.  Multilingual  capabilities  and service for the hearing  impaired are also
available.  The counselors  provide follow-up service to members to determine if
their  situation  was  resolved  or if  the  counselor  may  provide  additional
assistance.  Member satisfaction and outcomes  assessments are tracked through a
combination of member surveys, a quality assurance plan and system reports.

NON-PBM SERVICES

     In addition to PBM services,  we also provide  non-PBM  services  including
outpatient  infusion  therapy,  specialty  distribution  and vision  care to our
clients.  During  1998,  2.1% of our net  revenues  were  derived  from  non-PBM
services,  compared to 3.2% and 3.9% during  1997 and 1996,  respectively.  This
decline is partially  due to the  acquisition  of ValueRx,  which  significantly
increased the Company's PBM service revenues.

     OUTPATIENT  INFUSION  THERAPY  SERVICES - IVTX. We provide infusion therapy
services  which  involve  the  administration  of  prescription  drugs and other
products to a patient by catheter,  feeding tube or  intravenously,  through our
wholly owned  subsidiary  IVTx, Inc. IVTx's clients,  which include managed care
organizations,  third-party administrators, insurance companies, case management
companies,  unions and self-insured employers,  benefit from outpatient infusion
therapy  services  because the length of hospital  stays can be reduced.  Rather
than receiving  infusion therapy in a hospital,  IVTx provides  infusion therapy
services to  patients at home,  in a  physician's  office or in a  free-standing
center operated by a managed care  organization  or other entity.  IVTx provides
antimicrobial,     cardiovascular,    hematologic,    nutritional,    analgesic,
chemotherapeutic,   hydration,   endocrine,   respiratory  and  AIDS  management
treatments to patients.  IVTx  generally  prepares the  treatments in one of its
infusion  therapy  pharmacies,  which  are  licensed  independently  of our mail
pharmacies.  The treatments  are either  administered  under the  supervision of
IVTx's staff of registered nurses or licensed vocational nurses who are employed
at one of the IVTx  sites or,  in areas  where  IVTx  does not have a  facility,
through  contracted  registered nurses employed or otherwise retained by nursing
agencies.  IVTx  may also  contract  with  physicians  to  provide  consultation
services to its sites and contract  for pharmacy  services for patients who live
in outlying areas.

     We have facilities  supporting our infusion therapy  operations in Houston,
Texas; Dallas, Texas; Columbia,  Maryland; Maryland Heights, Missouri; Columbia,
Missouri; Northvale, New Jersey; Tempe, Arizona; and West Chester, Pennsylvania.
IVTx's  information  system  maintains  patient profiles and documents doses and
supplies  dispensed,  and its drug  utilization  review  component  accesses our
prescription records for members receiving both infusion and oral drug therapies
to screen for drug interactions, incompatibilities and allergies.

     SPECIALTY  DISTRIBUTION  SERVICES. We began offering specialty distribution
services during the fourth quarter of 1997 through our Tempe,  Arizona facility.
This service assists pharmaceutical  manufacturers with the distribution of, and
creation  of  a  database  of  information  for,   products   requiring  special
handling/packaging  or  products  targeted  to a specific  physician  or patient
population.

     VISION CARE  SERVICES.  Until  September  1998, we offered a managed vision
care program  through a network of  approximately  9,000  vision care  providers
consisting  primarily of optometrists and a smaller number of  ophthalmologists.
In addition to administering the network, we ground and edged lenses,  assembled
eyeglasses  and  distributed  eyeglasses  and contact lenses from our vision lab
formerly located in Earth City, Missouri.

     We entered  into an  agreement,  effective  September  1,  1998,  with Cole
Managed Vision ("Cole"), a subsidiary of Cole National Corporation,  pursuant to
which Cole  provides  certain  vision  care  services  for our clients and their
members.  The  agreement  enables us to focus on our PBM  business  while  still
offering a vision care service to our members by transferring  certain functions
performed by our Express  Scripts  Vision  Corporation  to Cole. The Cole vision
program is offered to substantially all of our PBM clients, and we receive a fee
from Cole based on usage of the vision benefit by members.  In conjunction  with
the Cole  agreement,  we also  announced  plans to close the  operations  of our
wholly owned  subsidiary,  PhyNet,  Inc., a vision  program  management  service
organization.

SUPPLIERS

     We maintain an extensive inventory in our mail pharmacies of brand name and
generic  pharmaceuticals.  If a drug is not in our  inventory,  we can generally
obtain it from a supplier  within one or two  business  days.  We  purchase  our
pharmaceuticals  either  directly  from  manufacturers  or through  wholesalers.
During 1998,  approximately  56.2% of our pharmaceutical  purchases were through
one  wholesaler,  most  of  which  were  brand  name  pharmaceuticals.   Generic
pharmaceuticals are generally purchased directly from manufacturers.  We believe
that   alternative   sources  of  supply  for  most   generic   and  brand  name
pharmaceuticals are readily available.

CLIENTS

     We are a major  provider  of PBM  services to the  managed  care  industry,
including  several  large HMOs,  and the employer  industry,  both  directly and
through third-party administrators.  Currently, some of our largest managed care
clients  are Aetna U.S.  Healthcare,  Inc.  ("Aetna";  the plans we service  are
composed  primarily  of the  plans of the  former  NYLCare  Health  Plans,  Inc.
("NYLCare")  entity,  which was a wholly  owned  subsidiary  of New York  Life),
Coventry Corporation  ("Coventry"),  and Blue Cross Blue Shield of Massachusetts
(which should begin  service with us during the third quarter of 1999).  Some of
our  largest  employer  groups  include  the  State  of  New  York  Empire  Plan
Prescription  Drug Program  (through a  subcontracting  relationship  with CIGNA
HealthCare), and the State of Ohio Bureau of Workers' Compensation Fund. We also
market  our  PBM  services  through  preferred  provider  organizations,   group
purchasing organizations,  health insurers, third-party administrators of health
plans and union-sponsored benefit plans.

     We provide  PBM  services,  including  informed  decision  counseling,  and
non-PBM services,  including infusion therapy services, to HMOs owned or managed
by Aetna/NYLCare,  and provide PBM services to insurance plans  underwritten and
administered  by  Aetna/NYLCare.  Of our net revenues from PBM services in 1998,
4.8% was for services provided to members of HMOs owned or managed by NYLCare or
insurance policies administered by NYLCare while NYLCare was a subsidiary of New
York Life.  Of our net  revenues  for non-PBM  services  in 1998,  21.5% was for
services  provided to members of HMOs owned or managed by NYLCare and  insurance
policies  administered  by NYLCare  while  NYLCare was a subsidiary  of New York
Life. In connection  with Aetna's  purchase of NYLCare,  we and Aetna reached an
agreement to extend our PBM service agreements with HMOs, excluding the informed
decision  counseling  component,  and our infusion  therapy  agreements  through
December 31, 2003,  with new pricing to take effect after December 31, 1999. The
informed  decision  counseling  and vision care (through our alliance with Cole)
agreements will continue  through  December 31, 1999. We also expect to continue
to provide PBM services to members of the NYLCare indemnity  programs until such
members are converted to Aetna  policies,  which is  anticipated to occur during
1999.  See Item 7 herein  and see  Note 4 of  Notes  to  Consolidated  Financial
Statements in Item 8 herein for additional discussion concerning Aetna/NYLCare.

     Upon completion of our pending  acquisition of DPS (assuming all conditions
necessary for the consummation  are satisfied),  United  HealthCare  Corporation
will become our largest client,  with approximately 10.5 million members.  DPS's
contract with United  HealthCare will expire in May, 2000, and United HealthCare
has  indicated  it will be moving  to  another  provider  at that  time.  In our
financial  analysis of the DPS acquisition,  we assumed United  HealthCare would
not  renew  its  contract.  However,  the  loss of  this  contract  and  related
transition issues may still materially adversely affect our business and results
of operations.

ACQUISITIONS AND STRATEGIC ALLIANCES

     On  February  9, 1999,  we  announced  that we had  executed  a  definitive
agreement  to acquire DPS from  SmithKline  Beecham  Corporation  and one of its
affiliates  for $700  million in cash.  We expect to  complete  the  acquisition
during the second  quarter of 1999.  We intend to finance  the  acquisition  and
refinance  all of our  existing  indebtedness  through  a  $1.1  billion  credit
facility and a $150 million senior subordinated bridge credit facility. Goodwill
and  customer  contract  amortization  from  the  DPS  acquisition  will  be tax
deductible.  Upon  completion of our  acquisition of DPS, we will continue to be
the third  largest  PBM in North  America in terms of total  members and we will
have one of the largest managed care  membership  bases of any PBM. In addition,
the acquisition will provide us with enhanced clinical capabilities, systems and
technologies.  Consummation of the  transaction is subject to customary  closing
conditions, and we cannot provide any assurance that all such conditions will be
satisfied such that the transaction may be consummated as planned.

     On April 1, 1998,  we acquired  the PBM business  known as  "ValueRx"  from
Columbia/HCA  Healthcare  Corporation  for  approximately  $460  million in cash
(including   approximately  $15  million  in  transaction  costs  and  executive
severance costs). Historically, while both we and ValueRx served all segments of
the PBM market,  we primarily  focused on managed  care and smaller  self-funded
plan sponsors,  and ValueRx  concentrated on health insurance carriers and large
employer and union groups.  We believe the ValueRx  acquisition has provided and
will continue to provide us with additional resources and expertise,  which will
allow us to better  serve our clients and  competitively  pursue new business in
all segments of the PBM market.

     In January  1996,  we acquired the pharmacy  claim  processing  business of
Eclipse Claims  Services,  Inc., one of the largest  processors of  prescription
drug claims in Canada.  In  connection  with this  acquisition,  we entered into
five-year  exclusive  contracts  to  provide  PBM  services  in  Canada  to both
Prudential Insurance Company of America's Canadian Operations ("Prudential") and
Aetna Life Insurance Company of Canada ("Aetna").  The assets of Prudential were
previously  acquired by London Life Insurance Company ("London Life"), with whom
we  reached  an  agreement  whereby we would be the  exclusive  provider  of PBM
services to London Life.  In late 1997,  London Life was acquired by  Great-West
Lifeco.  Inc.  ("Great-West"),  who  receives  PBM  services  from  one  of  our
competitors  in Canada.  Great-West  decided not to continue using our services,
and we have  agreed to  transition  their  business  to  another  provider.  The
transition should be substantially  completed during the second or third quarter
of 1999.

     On December 31, 1995, we entered into a series of agreements  with American
HealthCare  Systems Purchasing  Partners,  L.P. (now known as Premier Purchasing
Partners,  L.P.;  the  "Premier  Partnership"),  a health care group  purchasing
organization  affiliated with APS Healthcare,  Inc. (now known as Premier, Inc.;
"Premier").  Premier is the largest  voluntary health care alliance in the U.S.,
formed as a result of the mergers in late 1995 of three  predecessor  alliances,
American HealthCare Systems, Premier Health Alliance and SunHealth Alliance. The
Premier alliance includes  approximately 215 integrated health care systems that
own or operate  approximately  800  hospitals  and are  affiliated  with another
approximately 900 hospitals.  Among other things, the agreements designate us as
Premier's   exclusive   preferred   provider  of  outpatient   PBM  services  to
shareholders  of Premier and their  affiliated  health care entities,  plans and
facilities which participate in the Partnership's  purchasing programs. The term
of the agreement is ten years,  subject to early  termination by the Partnership
at five  years,  upon  payment  of an early  termination  fee to us.  Premier is
required to promote us as its  preferred PBM  provider.  An  individual  Premier
member  or  affiliated  managed  care  plan is not  required  to  enter  into an
agreement  with us,  but if it does so, the term of the  agreement  would be for
five  years.  Under the terms of the  agreements  with the  Partnership,  we now
provide service to a number of Premier  affiliates.  In May 1996, as a result of
the number of Premier plan members receiving our PBM services and the outcome of
certain joint drug purchasing initiatives, we issued 454,546 shares of our Class
A Common Stock to the Premier Partnership.  The Premier Partnership could become
entitled to receive up to an additional  4,500,000  shares of our Class A Common
Stock,  depending upon the number of members in Premier-affiliated  managed care
plans that  contract for our PBM services.  A calculation  is made on April 1 of
each  year  to  determine  if a stock  issuance  will be  made.  If the  Premier
Partnership  earns  stock  totaling  over 5% of our total  voting  stock,  it is
entitled to have its designee  nominated for election to our Board of Directors.
As of the  date  hereof,  the  Premier  Partnership  has  not  reached  this  5%
threshold.  See Note 3 of Notes to Consolidated  Financial  Statements in Item 8
herein for additional discussion concerning Premier.

     In November  1995, we entered into a ten-year  strategic  alliance with The
Manufacturers  Life Insurance Company  ("Manulife") one of the largest providers
of group  health  insurance  policies  in Canada,  pursuant  to which we are the
exclusive  provider of PBM services to Manulife.  As a result of this  alliance,
Manulife  can earn up to  approximately  474,000  shares  of our  Class A Common
Stock,  depending on its achievement of certain pharmacy claim volumes from 1996
to 2000.  To date,  we have not issued any shares to Manulife.  In addition,  if
Manulife  does not  terminate  the  alliance  in either year 6 or year 10 of the
agreement,  in each of such years it will  receive a warrant to  purchase  up to
237,000  shares of our Class A Common Stock  exercisable at 85% of the then fair
market value of such shares. The actual number of shares will depend upon claims
volume in such years. See Note 3 of Notes to Consolidated  Financial  Statements
in Item 8 herein for additional discussion concerning Manulife.

     In January  1995,  we entered  into an  exclusive  three-year  agreement to
provide  PBM  services  to  Coventry  Corporation,  pursuant  to which  Coventry
received 50,000 shares of our Class A Common Stock.  In December 1997,  Coventry
extended its  agreement  for an additional  two years.  In connection  with such
extension,  we issued, as an advance discount,  a seven-year warrant to purchase
an additional 50,000 shares of our Class A Common Stock,  exercisable at a price
of  $26.4544  per  share  (90% of the per  share  market  value  at the  time of
renewal).

COMPANY OPERATIONS

     GENERAL. In our various facilities in the United States, we own and operate
five mail  pharmacies  and five member  service/pharmacy  help desk call centers
(four of  which  are  linked  to  create a  virtual  call  center  environment).
Electronic  pharmacy  claims  processing  is  principally  directed  through our
Maryland  Heights,  Missouri  facility then routed to the  appropriate  computer
platform at our  Maryland  Heights,  Missouri or Tempe,  Arizona  facility or at
facilities  operated by Perot Systems,  which maintains  certain of our computer
hardware.  At our  Canadian  facility,  we  have  sales  and  marketing,  client
services,   pharmacy  help  desk,  clinical,   provider  relations  and  certain
management information systems capabilities.

     SALES AND  MARKETING;  CLIENT  SERVICE.  We market our PBM  services in the
United  States  primarily  through  an  internal  staff  of  regional  marketing
representatives  and sales  personnel  located in various cities  throughout the
United States. The marketing  representatives are supported by a staff of client
service  representatives.  Our sales and marketing  personnel and client service
representatives  are organized by type of business  served  (i.e.,  managed care
group,  employer  group,  etc.).  Marketing  in Canada is conducted by marketing
representatives  located  in  Mississauga,  Ontario,  who  are  assisted  by our
personnel  based in the United States.  Although we cross-sell our IVTx services
to our PBM clients,  IVTx employs its own sales and marketing and client service
personnel to take advantage of individual market opportunities.

     MEMBER  SERVICES.  We believe client  satisfaction is dependent upon member
satisfaction.  Members  can  call  us  toll-free,  24  hours  a day,  to  obtain
information  about  their  prescription  drug  plan.  We employ  member  service
representatives who are trained to respond to member inquiries.

     PROVIDER  RELATIONS.  Our  Provider  Relations  group  is  responsible  for
contracting  and  administering  our pharmacy  networks.  To  participate in our
retail pharmacy networks,  pharmacists must meet certain  qualifications and are
periodically  required to represent to us that their  applicable state licensing
requirements are being maintained and that they are in good standing. Pharmacies
can contact our  various  pharmacy  help desks  toll-free,  24 hours a day,  for
information and assistance in filling  prescriptions  for members.  In addition,
our Provider  Relations group audits selected  pharmacies in the retail pharmacy
networks to determine  compliance  with the terms of the contract with us or our
clients.

     CLINICAL  SUPPORT.   Our  Health  Management  Services  Department  employs
clinical  pharmacists,  data  analysts  and  outcomes  researchers  who  provide
technical support for our PBM services.  These staff members assist in providing
high level  clinical  pharmacy  services  such as  formulary  development,  drug
information  programs,  clinical  interventions with physicians,  development of
drug therapy  guidelines and the evaluation of drugs for inclusion in clinically
sound  therapeutic   intervention   programs.  The  Health  Management  Services
Department also analyzes and prepares reports on clinical  pharmacy data for our
clients and conducts  specific data analyses to evaluate the  cost-effectiveness
of certain drug therapies.

     INFORMATION  SYSTEMS.  Our  Information  Systems  department  supports  our
pharmacy claims  processing  systems and other  management  information  systems
which are essential to our operations.  Uninterrupted  point-of-sale  electronic
retail pharmacy claims processing is a significant  operational  requirement for
us, and we are in the  process of  integrating  the  systems  acquired  with the
ValueRx acquisition with our historical systems located at our Maryland Heights,
Missouri and Tempe,  Arizona facilities.  Substantially all claims are presently
directed  through our Maryland  Heights,  Missouri  facility  then routed to the
appropriate  computer  platform  at our  Maryland  Heights,  Missouri  or Tempe,
Arizona  facility,  or at facilities  operated by Perot Systems  (Perot  Systems
maintains  the  computer  hardware  for the ValueRx  systems at its  facility in
Richardson,  Texas).  Our historical  claims  processing  systems located in our
Maryland  Heights,  Missouri and Tempe,  Arizona  facilities  are designed to be
redundant,  which enables us to do  substantially  all claims  processing in one
facility if the other facility is unable to process  claims.  Disaster  recovery
services  for  the  ValueRx  systems  are  provided  by a third  party.  We have
substantial capacity for growth in our claims processing facilities.

COMPETITION

     We believe the primary  competitive  factors in each of our  businesses are
price,  quality of service and  breadth of  available  services.  We believe our
principal   competitive   advantages  are  our  size,  our   independence   from
pharmaceutical  manufacturer and drug store  ownership,  our strong managed care
and employer group customer base which supports the  development of advanced PBM
services and our commitment to provide  flexible and distinctive  service to our
clients.

     There are a large number of  companies  offering PBM services in the United
States.  Most of these companies are smaller than us and offer their services on
a local or  regional  basis.  We do,  however,  compete  with a number of large,
national companies,  including Merck-Medco Managed Care, L.L.C. (a subsidiary of
Merck & Co., Inc.), PCS, Inc. (a subsidiary of Rite-Aid  Corporation),  Caremark
International  Inc. (a subsidiary of MedPartners,  Inc.), and Advance  ParadigM,
Inc.,  as well as numerous  insurance  and Blue Cross and Blue Shield  plans and
certain  HMOs  which  have their own PBM  capabilities.  Several of these  other
companies may have greater financial, marketing and technological resources than
us.

     In  general,  consolidation  is a  critical  factor  in the  pharmaceutical
industry, and particularly so in the PBM segment.  Competitors that are owned by
pharmaceutical  manufacturers  or drug store chains may have pricing  advantages
that are  unavailable  to us and other  independent  PBMs.  However,  we believe
independence  from  pharmaceutical  manufacturer  and drug  store  ownership  is
important to certain clients,  and we believe this  independence  provides us an
advantage in marketing to those clients.

     On  February  9, 1999,  we  announced  that we had  executed  a  definitive
agreement to purchase DPS for $700 million. As more particularly discussed above
and in Item 7,  consummation of the transaction is subject to customary  closing
conditions, but is expected to occur during the second quarter of 1999.

     Some of our PBM services,  such as disease  management  services,  informed
decision  counseling  services  and  medical  information  management  services,
compete with those being offered by  pharmaceutical  manufacturers,  other PBMs,
large  national  companies,   specialized   disease  management   companies  and
information  service  providers.  Our non-PBM  services compete with a number of
large national companies as well as with local providers.

GOVERNMENT REGULATION

     Various  aspects of our  businesses  are governed by federal and state laws
and  regulations.  Since  sanctions may be imposed for violations of these laws,
compliance  is a  significant  operational  requirement.  We  believe  we are in
substantial  compliance  with all existing  legal  requirements  material to the
operation  of our  businesses.  There are,  however,  significant  uncertainties
involving the  application of many of these legal  requirements to our business.
In addition, there are numerous proposed health care laws and regulations at the
federal and state levels, many of which could adversely affect our business.  We
are unable to predict what additional federal or state legislation or regulatory
initiatives  may be enacted in the future relating to our business or the health
care industry in general,  or what effect any such  legislation  or  regulations
might  have on us.  We  cannot  provide  any  assurance  that  federal  or state
governments will not impose additional  restrictions or adopt interpretations of
existing  laws that could  have a material  adverse  affect on our  business  or
financial position.

     PHARMACY  BENEFIT  MANAGEMENT  REGULATION  GENERALLY.  Certain  federal and
related  state  laws and  regulations  affect or may  affect  aspects of our PBM
business. Among these are the following:

     FDA REGULATION. The U.S. Food and Drug Administration ("FDA") generally has
authority to regulate drug promotional materials that are disseminated "by or on
behalf of" a drug  manufacturer.  In January,  1998, the FDA issued a Notice and
Draft  Guidance  regarding  its intent to regulate  certain drug  promotion  and
switching activities of pharmacy benefit managers that are controlled,  directly
or indirectly, by drug manufacturers. The position taken by the FDA in the Draft
Guidance  was  that  promotional  materials  used by an  independent  PBM may be
subject to FDA regulation depending upon the circumstances, including the nature
of the relationship between the PBM and the manufacturer. We, along with various
other parties, submitted written comments to the FDA regarding the basis for FDA
regulation of PBM activities.  It was our position that,  while the FDA may have
jurisdiction to regulate drug manufacturers,  the Draft Guidance went beyond the
FDA's  jurisdiction.   After  extending  the  comment  period  due  to  numerous
objections  to the  proposed  Draft,  the FDA  essentially  withdrew  the  Draft
Guidance in the fall of 1998,  stating  that it would  reconsider  the basis for
such a Guidance.  The FDA has not addressed the issue since the  withdrawal  and
has  not  indicated  when or even if it will  continue  to  address  the  issue.
However, there can be no assurance that the FDA will not again attempt to assert
jurisdiction over certain aspects of our PBM business in the future and, in such
event, the impact could materially adversely affect our operations.

     ANTI-REMUNERATION  LAWS.  Medicare and Medicaid law prohibits,  among other
things,  an entity from paying or receiving,  subject to certain  exceptions and
"safe harbors," any  remuneration to induce the referral of Medicare or Medicaid
beneficiaries  or the  purchase (or the  arranging  for or  recommending  of the
purchase)  of items or services  for which  payment may be made under  Medicare,
Medicaid, or other federally-funded  state health care programs.  Several states
also have similar  laws that are not limited to services  for which  Medicare or
Medicaid  payment  may be made.  State  laws  vary and  have  been  infrequently
interpreted  by courts or regulatory  agencies.  Sanctions  for violating  these
federal and state anti-remuneration laws may include imprisonment,  criminal and
civil  fines,  and  exclusion  from  participation  in the Medicare and Medicaid
programs.

     The federal statute has been interpreted  broadly by courts,  the Office of
Inspector  General  (OIG)  within the  Department  of Health and Human  Services
(HHS), and administrative  bodies. Because of the federal statute's broad scope,
federal  regulations  establish  certain  "safe  harbors" from  liability.  Safe
harbors exist for certain  properly  reported  discounts  received from vendors,
certain  investment  interests,  and certain properly disclosed payments made by
vendors  to group  purchasing  organizations.  HHS has  previously  announced  a
proposed   safe  harbor  that  would  protect   certain   discount  and  payment
arrangements between PBMs and HMO risk contractors serving Medicaid and Medicare
members,  and an  interim  final rule is  currently  being  developed  by HHS. A
practice  that does not fall within a safe harbor is not  necessarily  unlawful,
but may be subject to scrutiny and  challenge.  In the absence of an  applicable
exception or safe harbor,  a violation of the statute may occur even if only one
purpose of a payment  arrangement is to induce  patient  referrals or purchases.
Among the practices that have been identified by the OIG as potentially improper
under the statute are certain  "product  conversion  programs" in which benefits
are given by drug  manufacturers  to  pharmacists  or physicians  for changing a
prescription  (or  recommending  or  requesting  such a change) from one drug to
another. Such laws have been cited as a partial basis, along with state consumer
protection laws discussed below, for investigations and multi-state  settlements
relating  to  financial  incentives  provided  by drug  manufacturers  to retail
pharmacies in connection with such programs.

     To our  knowledge,  these  anti-remuneration  laws have not been applied to
prohibit PBMs from receiving amounts from drug  manufacturers in connection with
drug purchasing and formulary management programs,  to therapeutic  intervention
programs conducted by independent PBMs, or to the contractual relationships such
as  those  we have  with  certain  of our  clients.  We  believe  that we are in
substantial  compliance  with the legal  requirements  imposed  by such laws and
regulations,  and  we  believe  that  there  are  material  differences  between
drug-switching  programs  that have been  challenged  under  these  laws and the
programs we offer to our clients.  However,  there can be no  assurance  that we
will not be subject to scrutiny or challenge under such laws or regulations. Any
such challenge could have a material adverse effect on us.

     ERISA  REGULATION.  The  Employee  Retirement  Income  Security Act of 1974
("ERISA")  regulates  certain  aspects of employee  pension  and health  benefit
plans,   including  self-funded  corporate  health  plans  with  which  we  have
agreements to provide PBM services.  We believe that the conduct of our business
is not  subject  to the  fiduciary  obligations  of  ERISA,  but there can be no
assurance that the U.S.  Department of Labor,  which is the agency that enforces
ERISA,  would not assert that the fiduciary  obligations  imposed by the statute
apply to certain aspects of our operations.

     In addition to its fiduciary  provisions,  ERISA imposes civil and criminal
liability  on service  providers to health  plans and certain  other  persons if
certain forms of illegal remuneration are made or received.  These provisions of
ERISA are  similar,  but not  identical,  to the health  care  anti-remuneration
statutes discussed in the immediately  preceding section;  in particular,  ERISA
lacks the statutory and regulatory "safe harbor"  exceptions  incorporated  into
the health  care  statute.  Like the health  care  anti-remuneration  laws,  the
corresponding  provisions of ERISA are broadly written and their  application to
particular cases is often uncertain. We have implemented policies, which include
disclosure to health plan sponsors  with respect to any  commissions  paid by us
that might fall within the scope of such provisions,  and accordingly believe we
are in substantial  compliance with these provisions of ERISA.  However,  we can
provide no  assurance  that our  policies in this  regard  would be found by the
appropriate enforcement authorities to meet the requirements of the statute.

     PROPOSED CHANGES IN CANADIAN  HEALTHCARE  SYSTEM. In Canada, the provincial
health plans  provide  universal  coverage for basic health care  services,  but
prescription  drug coverage under the government  plans is provided only for the
elderly  and the  indigent.  In late  1997,  a  proposal  was made by a  federal
government  health care task force to include  coverage for  prescription  drugs
under the provincial  health insurance  plans,  which report was endorsed by the
federal  government's  Health Minister.  This report was advisory in nature, and
not  binding  upon the  federal  or  provincial  governments.  We  believe  this
initiative  is dormant at the present  time,  and we are unable to determine the
likelihood of adoption of the proposal in the future.

     Numerous state laws and regulations also affect aspects of our PBM
business. Among these are the following:

     COMPREHENSIVE  PBM  REGULATION.  Although  no state has passed  legislation
regulating PBM activities in a comprehensive  manner,  such legislation has been
introduced  in the past in  California  and  Virginia,  and bills were  recently
proposed in Texas and Colorado. Such legislation, if enacted in a state in which
we have a significant  concentration  of business,  could  adversely  impact our
operations.

     CONSUMER  PROTECTION  LAWS. Most states have consumer  protection laws that
have been the basis for investigations and multi-state  settlements  relating to
financial  incentives  provided by drug  manufacturers  to retail  pharmacies in
connection with drug switching programs.  In addition,  pursuant to a settlement
agreement  entered into with seventeen  states on October 25, 1995,  Merck-Medco
Managed Care, LLC ("Medco"),  the PBM subsidiary of pharmaceutical  manufacturer
Merck & Co.,  agreed to have  pharmacists  affiliated  with Medco  mail  service
pharmacies  disclose to  physicians  and  patients the  financial  relationships
between  Merck,  Medco,  and the mail  service  pharmacy  when such  pharmacists
contact physicians seeking to change a prescription from one drug to another. We
believe that our contractual  relationships  with drug  manufacturers and retail
pharmacies  do  not  include  the  features  that  were  viewed  by  enforcement
authorities as problematic in these settlement agreements. However, no assurance
can be given that we will not be subject to scrutiny or  challenge  under one or
more of these laws.

     NETWORK  ACCESS  LEGISLATION.  A  majority  of states now have some form of
legislation affecting our ability to limit access to a pharmacy provider network
or from  removing  network  providers.  Such  legislation  may require us or our
client to admit any retail  pharmacy  willing to meet the plan's price and other
terms for network  participation  ("any willing provider"  legislation);  or may
provide that a provider may not be removed from a network  except in  compliance
with certain procedures ("due process" legislation). We have not been materially
affected by these  statutes  because we maintain a large  network of over 52,000
retail   pharmacies  and  will  admit  any  licensed  pharmacy  that  meets  our
credentialling criteria,  involving such matters as adequate insurance coverage,
minimum  hours of  operation,  and the  absence of  disciplinary  actions by the
relevant state agencies.

     LEGISLATION  IMPOSING  PLAN DESIGN  RESTRICTIONS.  Some states have enacted
legislation   that  prohibits  the  plan  sponsor  from   implementing   certain
restrictive  design  features,  and many states have  introduced  legislation to
regulate various aspects of managed care plans, including provisions relating to
the pharmacy  benefit.  For example,  some states,  under so-called  "freedom of
choice" legislation, provide that members of the plan may not be required to use
network  providers,  but must  instead be provided  with  benefits  even if they
choose to use  non-network  providers.  Other  states have  enacted  legislation
purporting to prohibit health plans from offering members  financial  incentives
for use of mail service  pharmacies.  Legislation  has been  introduced  in some
states to prohibit or restrict therapeutic intervention,  or to require coverage
of all FDA approved drugs.  Other states mandate coverage of certain benefits or
conditions. Such legislation does not generally apply to us, but it may apply to
certain of our clients (HMOs and health  insurers).  If such legislation were to
become widely  adopted and broad in scope,  it could have the effect of limiting
the economic benefits achievable through pharmacy benefit management. This could
have a material adverse effect on our business.

     LICENSURE LAWS.  Many states have licensure or registration  laws governing
certain types of ancillary health care organizations,  including PPOs, TPAs, and
companies  that provide  utilization  review  services.  The scope of these laws
differs  significantly  from state to state, and the application of such laws to
the activities of pharmacy benefit managers often is unclear. We have registered
under such laws in those  states in which we have  concluded,  after  discussion
with the appropriate state agency, that such registration is required.

     LEGISLATION AFFECTING DRUG PRICES. Some states have adopted so-called "most
favored nation" legislation providing that a pharmacy participating in the state
Medicaid  program  must give the state the best  price that the  pharmacy  makes
available to any third party plan.  Such  legislation  may adversely  affect our
ability to  negotiate  discounts in the future from  network  pharmacies.  Other
states have enacted  "unitary  pricing"  legislation,  which  mandates  that all
wholesale  purchasers  of drugs  within  the  state be given  access to the same
discounts and incentives.  Such  legislation has been introduced in the past but
not enacted in Missouri, Arizona,  Pennsylvania,  and New York, and is presently
being  considered  in New Mexico,  all states  where the Company  operates  mail
service  pharmacies.  Such  legislation,  if enacted in a state where one of our
mail  service  pharmacies  is  located,  could  adversely  affect our ability to
negotiate discounts on our purchase of prescription drugs to be dispensed by our
mail service pharmacies.

     REGULATION OF FINANCIAL RISK PLANS. Fee-for-service prescription drug plans
are generally not subject to financial regulation by the states. However, if the
PBM  offers to  provide  prescription  drug  coverage  on a  capitated  basis or
otherwise  accepts  material  financial  risk in providing the benefit,  laws in
various  states may regulate  the plan.  Such laws may require that the party at
risk establish reserves or otherwise demonstrate financial responsibility.  Laws
that may apply in such cases include insurance laws, HMO laws or limited prepaid
health  service plan laws. In those cases in which we have contracts in which we
are  materially  at risk to provide  the  pharmacy  benefit,  we believe we have
complied with all applicable laws.

     Many of these  state  laws may be  preempted  in whole or in part by ERISA,
which provides for comprehensive  federal  regulation of employee benefit plans.
However,  the  scope  of  ERISA  preemption  is  uncertain  and  is  subject  to
conflicting  court  rulings,  and in any event we  provide  services  to certain
clients, such as governmental  entities,  that are not subject to the preemption
provisions  of ERISA.  Other state laws may be invalid in whole or in part as an
unconstitutional  attempt by a state to regulate  interstate  commerce,  but the
outcome of  challenges  to these laws on this basis is  uncertain.  Accordingly,
compliance  with  state  laws  and  regulations  is  a  significant  operational
requirement for us.

     MAIL  PHARMACY  REGULATION.  Our mail  service  pharmacies  are  located in
Arizona, Missouri, New Mexico, New York and Pennsylvania, and we are licensed to
do business  as a pharmacy in each such state.  Many of the states into which we
deliver pharmaceuticals have laws and regulations that require out-of-state mail
service pharmacies to register with, or be licensed by, the board of pharmacy or
similar  regulatory body in the state.  These states  generally  permit the mail
service  pharmacy to follow the laws of the state  within which the mail service
pharmacy  is  located,  although  one  state  also  requires  that we  employ  a
pharmacist  licensed  in that  state.  Another  state  has  proposed  a  similar
requirement.  We have registered in every state in which, to our knowledge, such
registration is required.

     One state has a statute that purports to prohibit  residents from obtaining
prescription  drugs by mail if the mail order business of the company dispensing
the drugs  represents  more than a specified  percentage of the company's  total
volume of pharmacy business.  The statute is ambiguous in certain respects,  but
we do not believe our mail order volume exceeds the threshold percentage. We are
licensed as a pharmacy in that state. No enforcement action has been taken under
the statute  against us, and to our  knowledge,  no such  enforcement  action is
contemplated.  Approximately  2.5% of our  revenues  come from mail  delivery of
prescription  drugs into that state.  If an  enforcement  action were  commenced
against  us under  that  statute,  we would  consider  all of our  alternatives,
including challenging the validity of the statute.

     Other statutes and regulations affect our mail service operations.  Federal
statutes  and  regulations  govern  the  labeling,  packaging,  advertising  and
adulteration of prescription drugs and the dispensing of controlled  substances.
The Federal Trade  Commission  requires mail order sellers of goods generally to
engage in truthful  advertising,  to stock a reasonable supply of the product to
be sold,  to fill mail orders within  thirty days,  and to provide  clients with
refunds  when  appropriate.  The United  States  Postal  Service  has  statutory
authority to restrict the  transmission of drugs and medicines  through the mail
to a degree that could have an adverse effect on our mail service operations.

     REGULATION OF INFORMED DECISION COUNSELING AND DISEASE MANAGEMENT SERVICES.
Our health care decision support counseling and disease management  programs are
affected  by many of the same types of state laws and  regulations  as our other
activities.  In addition,  all states  regulate the practice of medicine and the
practice of  nursing.  We do not believe our  informed  decision  counseling  or
disease management  activities constitute either the practice of medicine or the
practice of nursing. However, there can be no assurance that a regulatory agency
in one or more states may not assert a contrary  position,  and we are not aware
of any controlling legal precedent for services of this kind.

     PRIVACY AND CONFIDENTIALITY LEGISLATION. Most of our activities involve the
receipt  or use  of  confidential,  medical  information  concerning  individual
members.  In addition,  we use aggregated  and anonymized  data for research and
analysis  purposes.  Legislation  has been  proposed at the federal level and in
several  states to  restrict  the use and  disclosure  of  confidential  medical
information.  To date,  no such  legislation  has been  enacted  that  adversely
impacts our ability to provide our services,  but there can be no assurance that
federal or state governments will not enact legislation,  impose restrictions or
adopt interpretations of existing laws that could have a material adverse effect
on our operations.

     NON-PBM  REGULATORY  ENVIRONMENT.  Our  non-PBM  activities  operate  in  a
regulatory environment that is quite similar to that of our PBM activities.

     REGULATION OF INFUSION  THERAPY  SERVICES.  Our infusion  therapy  services
business  is subject to many of the same or similar  state laws and  regulations
affecting our pharmacy benefit  management  business.  In addition,  some states
require that providers of infusion therapy services be licensed. We are licensed
as a home health agency and pharmacy in Texas,  as a residential  service agency
and pharmacy in Maryland, and as a pharmacy in New Jersey, Missouri, Arizona and
Pennsylvania. We are also licensed as a non-resident pharmacy in various states.
We  believe  that  we  are  in  substantial   compliance   with  such  licensing
requirements.

     The  Joint  Commission  on   Accreditation   of  Healthcare   Organizations
("JCAHO"), a non-profit, private organization, has established written standards
for health care  organizations and home care services,  including  standards for
services  provided  by home  infusion  therapy  companies.  All of our  infusion
therapy facilities have received JCAHO accreditation,  which allows us to market
infusion  therapy services to Medicare and Medicaid  programs.  If we expand our
home  infusion  therapy  services  to other  states or to  Medicare  or Medicaid
programs,  we  may  be  required  to  comply  with  other  applicable  laws  and
regulations.

     FUTURE  REGULATION.  We are unable to predict  accurately  what  additional
federal or state  legislation  or regulatory  initiatives  may be enacted in the
future  relating to our  businesses or the health care  industry in general,  or
what effect any such  legislation or regulations  might have on us. There can be
no  assurance  that  federal or state  governments  will not  impose  additional
restrictions  or adopt  interpretations  of  existing  laws  that  could  have a
material adverse effect on our business or financial position.

SERVICE MARKS AND TRADEMARKS

     We  have   registered   the  service  marks  "Express   Scripts",   "PERx",
"ExpressComp",  "ExpressReview",   "ExpressTherapeutics",   "IVTx",  "PERxCare",
"PERxComp",  "RxWizard",  "PTE",  "ValueRx" and "Value Health,  Inc.",  with the
United  States  Patent and  Trademark  Office.  Our  rights to these  marks will
continue  so long as we comply  with the usage,  renewal  filing and other legal
requirements  relating to the renewal of service marks. We are in the process of
applying for  registration of several other  trademarks and service marks. If we
are unable to obtain any additional registrations,  we believe there would be no
material adverse effect on our business.

INSURANCE

     Our PBM operations,  including the dispensing of pharmaceutical products by
our mail service  pharmacies,  and the services  rendered in connection with our
disease management and informed decision  counseling  services,  and our non-PBM
operations,  such as the products and services  provided in connection  with our
infusion  therapy  programs  (including the associated  nursing  services),  may
subject  us to  litigation  and  liability  for  damages.  We  believe  that our
insurance protection is adequate for our present business operations,  but there
can be no  assurance  that we will be able  to  maintain  our  professional  and
general  liability  insurance  coverage  in the  future or that  such  insurance
coverage will be available on  acceptable  terms or adequate to cover any or all
potential  product or professional  liability  claims.  A successful  product or
professional  liability  claim in excess of our insurance  coverage,  or one for
which an exclusion from coverage  applies,  could have a material adverse effect
upon our financial position or results of operations.

EMPLOYEES

     As of March 1, 1999, we employed a total of 3,283 employees in the U.S. and
71 employees in Canada.  Approximately 375 of the U.S.  employees are members of
collective  bargaining  units.  Specifically,  we employ  members of the Service
Employees International Union at our Bensalem, Pennsylvania facility, members of
the United Auto Workers Union at our Farmington Hills,  Michigan  facility,  and
members  of the  United  Food  and  Commercial  Workers  Union  ("UFCW")  at our
Albuquerque,  New Mexico facility.  One of our collective  bargaining agreements
with the UFCW expires on July 1, 1999. We have not begun  negotiations  with the
UFCW for this contract at this time.

EXECUTIVE OFFICERS OF THE REGISTRANT

     Pursuant to General Instruction G(3) of the Annual Report on Form 10-K, the
information  regarding executive officers of the Company required by Item 401 of
Regulation S-K is hereby included in Part I of this report.

     The  executive  officers of the Company and their ages as of March 1, 1999,
are as follows:

        NAME                   AGE         POSITION
                               
      Howard L. Waltman         66    Chairman of the Board
      Barrett A. Toan           51    President, Chief Executive
                                         Officer and Director
      Stuart L. Bascomb         57    Executive Vice President
      Thomas M. Boudreau        47    Senior Vice President of
                                      Administration, General Counsel
                                         and Secretary
      Patrick J. Byrne          43    Senior Vice President Plymouth
                                         Site Operations
      Robert W. (Joe) Davis     52    Senior Vice President and Chief
                                         Information Systems Officer
      Linda L. Logsdon          51    Senior Vice President of Health
                                         Management Services
      David A. Lowenberg        49    Senior Vice President and
                                         Director of Site Operations
      George Paz                43    Senior Vice President and Chief
                                         Financial Officer
      Jean-Marc Quach           40    Senior Vice President and Chief
                                         of Staff
      Kurt D. Blumenthal        54    Vice President of Finance
      Joseph W. Plum            51    Vice President and Chief
                                         Accounting Officer

     Mr. Waltman was elected Chairman of the Board of the Company in March 1992.
Mr.  Waltman has been a director of the Company since its inception in September
1986.  From  September  1992 to December 31,  1995,  Mr.  Waltman  served as the
Chairman  of the Board of NYLCare  Health  Plans,  Inc.,  which was an  indirect
wholly-owned subsidiary of New York Life Insurance Company at the time.

     Mr. Toan was elected  Chief  Executive  Officer in March 1992 and President
and a director in October 1990.  Mr. Toan has been an executive  employee of the
Company since May 1989.

     Mr.  Bascomb was elected  Executive  Vice President of the Company in March
1989, and also served as Chief  Financial  Officer and Treasurer from March 1992
until May 1996.

     Mr.  Boudreau  was  elected  Senior  Vice  President,  General  Counsel and
Secretary of the Company in October  1994.  He has served as General  Counsel of
the Company since June 1994.  From September 1984 until June 1994, Mr.  Boudreau
was a partner in the St. Louis law firm of Husch & Eppenberger.

     Mr. Byrne was elected  Senior Vice  President  Plymouth Site  Operations in
May,  1998.  From  April 1996  until  October  1997,  Mr.  Byrne  served as Vice
President of  Underwriting  for ValueRx,  and then served as Vice  President and
General  Manager  for the  National  Employer  Business  Unit of ValueRx for the
period November 1997 until May 1998. From 1991 until March 1996, Mr. Byrne was a
Director of Finance for United Healthcare Corporation.

     Mr. Davis was elected Senior Vice President and Chief  Information  Systems
Officer of the  Company in  September  1997.  Mr.  Davis  served as  Director of
Technical  Services and Computer  Operations of the Company from July 1993 until
July 1995, and as Vice President and General Manager of St. Louis  Operations of
the Company from July 1995 until September 1997.

     Ms. Logsdon was elected Senior Vice President of Health Management Services
in May, 1997, and served as Vice President of Demand and Disease Management from
November  1996 until that time.  Prior to joining the Company in November  1996,
Ms. Logsdon served as Vice President of Corporate  Services and Chief  Operating
Officer  of  United  HealthCare's  Midwest  Companies-GenCare/Physicians  Health
Plan/MetraHealth,  a  St.  Louis-based  health  maintenance  organization,  from
February 1995 to October 1996, and as Deputy Director/Vice  President of GenCare
Health Systems,  Inc., also a St. Louis-based  health maintenance  organization,
from June 1992 to February 1995.

     Mr.  Lowenberg  was elected  Senior  Vice  President  and  Director of Site
Operations of the Company in October,  1994 and Vice President of the Company in
November  1993.  Mr.  Lowenberg  also  served as  General  Manager  of the Tempe
facility from March 1993 until January 1995.

     Mr. Paz joined the Company and was elected  Senior Vice President and Chief
Financial  Officer in January 1998. Prior to joining the Company,  Mr. Paz was a
partner  in the  Chicago  office  of  Coopers & Lybrand  from  December  1995 to
December  1997,  and served as  Executive  Vice  President  and Chief  Financial
Officer of Life Partners  Group,  Inc., a life insurance  company,  from October
1993 until December 1995.

     Mr. Quach was elected Senior Vice President and Chief of Staff in May 1998.
Prior to joining the Company,  Mr. Quach was the Director of Marketing for Roche
Diagnostics  during the period  April 1996 to May 1998.  Mr. Quach served as the
Director of Pharmacy for NYLCare  Health  Plans,  Inc. for the period  September
1991 to April 1996,  which was an indirect  wholly-owned  subsidiary of New York
Life Insurance Company at the time.

     Mr.  Blumenthal  was elected  Vice  President  of Finance in May 1995,  and
served  as Acting  Chief  Financial  Officer  of the  Company  from July 1996 to
January 1998.  From August 1993 to February 1995, Mr.  Blumenthal  served as the
Chief Financial Officer of President Baking Co.

     Mr. Plum was elected Vice President in October 1994 and has served as Chief
Accounting Officer since March 1992 and Corporate Controller since March 1989.

ITEM 2 - PROPERTIES

         We operate our United States and Canadian PBM and non-PBM businesses
out of leased and owned facilities throughout the United States and Canada. All
of our facilities are leased except for our Albuquerque, New Mexico facility,
which we own.

              PBM FACILITIES                             NON-PBM FACILITIES
        Maryland Heights, Missouri                   Maryland Heights, Missouri
           Earth City, Missouri                          Columbia, Missouri
              Tempe, Arizona                               Dallas, Texas
            Plymouth, Minnesota                            Houston, Texas
          Bensalem, Pennsylvania                         Columbia, Maryland
              Troy, New York                               Tempe, Arizona
        Farmington Hills, Michigan                     Northvale, New Jersey
          Albuquerque, New Mexico                    West Chester, Pennsylvania
           Mississauga, Ontario

     Our Maryland  Heights,  Missouri  facility  houses our  corporate  offices.
IVTx's  corporate  offices are also  located at our Maryland  Heights,  Missouri
facility.  The non-PBM specialty  distribution  services are operated out of our
facility in Tempe,  Arizona.  We believe our facilities have been generally well
maintained and are in good operating condition.  Our existing facilities contain
approximately 600,000 square feet in area, in the aggregate.

     During  1998,  we  entered  into an  operating  lease  for a new  corporate
headquarters  facility to be located adjacent to our existing  Maryland Heights,
Missouri facility, which will contain approximately 140,000 square feet in area.
The new  building is  presently  under  construction  and we  anticipate  taking
possession  during the second quarter of 1999. We are continuing to evaluate our
future requirements for additional space.

     We own computer systems for both the Maryland Heights,  Missouri and Tempe,
Arizona sites.  Computer systems to process the traditional ValueRx business are
located at Perot Systems' facility in Richardson, Texas. Perot Systems maintains
the computer  hardware on our behalf.  Our software for drug utilization  review
and other  products  has been  developed  internally  by us or  purchased  under
perpetual,  nonexclusive  license  agreements  with third parties.  Our computer
systems at each site are  extensively  integrated and share common files through
local and wide  area  networks.  An  uninterruptable  power  supply  and  diesel
generator allow our computers,  telephone systems and mail pharmacy at each site
to continue to function  during a power outage.  To protect against loss of data
and extended downtime, we store software and redundant files at both on-site and
off-site  facilities on a regular basis and have contingency  operation plans in
place.  We cannot,  however,  provide  any  assurance  that our  contingency  or
disaster recovery plans would adequately address all relevant issues.

ITEM 3 - LEGAL PROCEEDINGS

     As discussed in detail in our Quarterly  Report on Form 10-Q for the period
ended June 30, 1998, filed with the Securities and Exchange Commission on August
13, 1998 (the "Second Quarter 10-Q"), we acquired all of the outstanding capital
stock of Value  Health,  Inc.,  a  Delaware  corporation  ("VHI"),  and  Managed
Prescription  Network,  Inc.,  a  Delaware  corporation  ("MPN")  from  Columbia
HCA/HealthCare Corporation ("Columbia") and its affiliates on April 1, 1998 (the
"Acquisition").  VHI, MPN and/or their subsidiaries (collectively, the "Acquired
Entities"), were party to various legal proceedings, investigations or claims at
the time of the Acquisition. The effect of these actions on our future financial
results is not subject to reasonable estimation because considerable uncertainty
exists  about the  outcomes.  Nevertheless,  in the opinion of  management,  the
ultimate liabilities resulting from any such lawsuits,  investigations or claims
now pending should not materially  affect our consolidated  financial  position,
results of operations  or cash flows.  A brief update of the most notable of the
proceedings follows:

     VHI and several of its subsidiaries are party to two securities  litigation
matters,  BASH,  ET AL. V. VALUE  HEALTH,  INC.,  ET AL., No.  3:97cv2711  (JCH)
(D.Conn.),  and FREEDMAN, ET AL. V. VALUE HEALTH, INC., ET AL., No. 3:95 CV 2038
(JCH)  (D.Conn).  The two lawsuits,  filed in 1995,  allege that VHI and certain
other defendants made false or misleading statements to the public in connection
with VHI's  acquisition of Diagnostek,  Inc. in 1995. On April 24, 1998, the two
lawsuits were consolidated.  On February 18, 1999, the court granted plaintiffs'
motions for class  certification  and  certified a class  consisting  of (i) all
persons who purchased or otherwise acquired shares of VHI during the period from
April 3, 1995,  through  and  including  November 7, 1995,  including  those who
acquired shares in connection with the Diagnostek  merger;  and (ii) all persons
who purchased or otherwise  acquired shares of Diagnostek during the period from
March 27, 1995,  through and including July 28, 1995.  Expert discovery is to be
completed by June 17, 1999, and any dispositive  motions must be filed within 30
days thereafter.

     In connection with the Acquisition,  Columbia has agreed to defend and hold
us and our  affiliates  (including  VHI) harmless from and against any liability
that  may  arise  in  connection  with  either  of  the  foregoing  proceedings.
Consequently,  we do not  believe  we  will  incur  any  material  liability  in
connection with these matters.

     In addition,  in the  ordinary  course of our  business,  there have arisen
various legal  proceedings,  investigations or claims now pending against us and
our subsidiaries  unrelated to the  Acquisition.  The effect of these actions on
future  financial  results  is not  subject  to  reasonable  estimation  because
considerable uncertainty exists about the outcomes. Nevertheless, in the opinion
of  management,  the  ultimate  liabilities  resulting  from any such  lawsuits,
investigations or claims now pending will not materially affect our consolidated
financial position, results of operations or cash flows.

     Since 1993, retail pharmacies have filed over 100 separate lawsuits against
drug  manufacturers,  wholesalers and certain PBMs,  challenging brand name drug
pricing practices under various state and federal antitrust laws. The plaintiffs
alleged,  among other things,  that the manufacturers  had offered,  and certain
PBMs had  knowingly  accepted,  discounts and rebates on purchases of brand name
prescription  drugs  that  violated  the  federal   Robinson-Patman   Act.  Some
plaintiffs also filed claims against the drug manufacturers and drug wholesalers
alleging price fixing of  pharmaceutical  drugs in violation of Section 1 of the
Sherman Act, and these claims were certified as a class action. Some of the drug
manufacturers  settled  both the  Sherman  Act and the  Robinson  Patman  claims
against them. The class action Sherman Act  settlements  generally  provide that
the  manufacturers  will not  refuse  to pay  discounts  or  rebates  to  retail
pharmacies based on their status as such.  Settlements with plaintiffs who opted
out of the class are not part of the public record.  The drug  manufacturer  and
wholesaler  defendants  in the class  action  who did not settle  were  recently
dismissed by the court on a motion for directed  verdict.  Plaintiffs  who opted
out of the class action will still have the opportunity to try their Sherman Act
claims  in   separate   lawsuits.   The  class   action  did  not   involve  the
Robinson-Patman claims, so many of those matters are still pending. We are not a
party to any of these  proceedings.  To date, we do not believe any  settlements
have had a material adverse effect on our business.  However,  we cannot provide
any assurance that the terms of the  settlements  will not materially  adversely
affect us in the future. In addition,  we cannot predict the outcome or possible
ramifications  to our business of the cases in which the  plaintiffs  are trying
their claims separately, and we cannot provide any assurance that we will not be
made a party to any such separate lawsuits in the future.

ITEM 4 - SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

     No matters were  submitted to a vote of security  holders during the fourth
quarter of 1998.

                                     PART II


ITEM 5 - MARKET FOR REGISTRANT'S COMMON EQUITY AND RELATED STOCKHOLDER MATTERS

 MARKET PRICE OF AND DIVIDENDS ON THE REGISTRANT'S COMMON EQUITY AND RELATED 
                              STOCKHOLDER MATTERS

     MARKET INFORMATION.  Our Class A Common Stock has been traded on the Nasdaq
National  Market  ("Nasdaq")  tier of The Nasdaq  Stock  Market under the symbol
"ESRX" since June 9, 1992.  Prior to that time,  there was no public  market for
our Class A Common  Stock.  The high and low prices,  as reported by the Nasdaq,
are set  forth  below  for the  periods  indicated.  These  prices  reflect  the
two-for-one  split on October 30, 1998, in the form of a 100% stock  dividend to
holders of record on October 20, 1998.

<TABLE>
                                       Fiscal Year 1998 Fiscal Year 1997
<CAPTION>

Class A Common Stock           High          Low           High           Low
<S>                         <C>          <C>           <C>            <C>     

  First Quarter             $ 42.750     $ 27.000      $ 19.125       $ 15.625
  Second Quarter              45.000       35.500        24.500         16.375
  Third Quarter               45.250       31.625        27.250         20.750
  Fourth Quarter              69.000       33.875        32.375         25.313

</TABLE>

     Our Class B Common Stock has no  established  public  trading  market,  but
those shares will  automatically  convert to Class A Common Stock on a share for
share  basis  upon  transfer  thereof  to any  entity  other  than New York Life
Insurance Company or one of its affiliates.

     HOLDERS.  As of March 1, 1999, there were 209 stockholders of record of our
Class A Common  Stock,  and 1 holder of record of our Class B Common  Stock.  We
estimate there are  approximately  9,000 beneficial owners of the Class A Common
Stock.

     DIVIDENDS.  The Board of Directors  has not declared any cash  dividends on
our common stock since the initial public offering.  The Board of Directors does
not currently  intend to declare any cash dividends in the  foreseeable  future.
The terms of our existing credit facility contains,  and the terms of the credit
facility we intend to consummate in connection  with the pending DPS acquisition
will  contain,  certain  restrictions  on our  ability  to  declare  or pay cash
dividends.

     RECENT SALES OF UNREGISTERED SECURITIES

     None.

ITEM 6 - SELECTED FINANCIAL DATA

<TABLE>
                                                                       YEAR ENDED DECEMBER 31,
<CAPTION>


(IN THOUSANDS, EXCEPT PER SHARE DATA)          1998(2)           1997            1996            1995           1994
<S>                                         <C>             <C>             <C>             <C>            <C>         
- -----------------------------------------------------------------------------------------------------------------------
STATEMENT OF OPERATIONS DATA:
Net revenues                                $  2,824,872    $  1,230,634    $    773,615    $    544,460   $    384,504
                                          -----------------------------------------------------------------------------
Costs and expenses:
    Cost of revenues                           2,584,997       1,119,167         684,882         478,283        338,151
    Selling, general and administrative          148,990          62,617          49,103          37,300         25,882
    Corporate restructuring                        1,651               -               -               -              -
                                          -----------------------------------------------------------------------------
                                               2,735,638       1,181,784         733,985         515,583        364,033
                                          -----------------------------------------------------------------------------
Operating income                                  89,234          48,850          39,630          28,877         20,471
Interest income (expense), net                  (12,994)           5,856           3,450             757            305
                                          -----------------------------------------------------------------------------
Income before income taxes                        76,240          54,706          43,080          29,634         20,776
Provision for income taxes                        33,566          21,277          16,932          11,307          8,053
                                          -----------------------------------------------------------------------------
Net income                                $       42,674  $       33,429   $      26,148   $      18,327  $      12,723
                                          =============================================================================
Earnings per share(3)
     Basic                                $         1.29  $         1.02   $        0.81   $        0.62  $        0.43  
     Diluted                              $         1.27  $         1.01   $        0.80   $        0.60  $        0.42  
     
Weighted average shares outstanding(3)
     Basic                                        33,105          32,713          32,160          29,560         29,588
     Diluted                                      33,698          33,122          32,700          30,545         30,293
- -----------------------------------------------------------------------------------------------------------------------
Balance Sheet Data:
Cash                                       $     122,589  $       64,155   $      25,211   $      11,506   $      5,742
Working capital                                  117,611         166,062         128,259          58,653         38,082
Total assets                                   1,095,461         402,508         300,425         164,088        108,922
Debt:
     Short-term debt                              54,000
     Long-term debt                              306,000
Stockholders' equity                             249,694         203,701         164,090          77,379         52,485
- -----------------------------------------------------------------------------------------------------------------------
Selected Data:
Pharmacy benefit covered lives                    22,900          12,600           9,900           8,100          5,700
Annual drug spending(3)                     $  4,495,000    $  2,486,000    $  1,636,000    $  1,172,000     $  716,000
Pharmacy network  claims processed               113,177          73,164          57,838          42,871         26,323
Mail pharmacy  prescriptions filled                7,426           3,899           2,770           2,129          1,594
EBITDA(4)                                   $    117,318    $     59,320    $     46,337    $     33,258     $   23,795
- -----------------------------------------------------------------------------------------------------------------------
<FN>
     (1)Earnings  per share and weighted  average shares  outstanding  have been
restated to reflect the two-for-one stock split effective October 30, 1998.

     (2)Includes  the  acquisition  of ValueRx  effective  April 1,  1998.  Also
includes a corporate  restructuring charge in 1998 of $1,651 ($1,002 after tax).
Excluding this  restructuring  charge,  our basic and diluted earnings per share
would  have  been  $1.32  and  $1.30,  respectively.   

     (3)Annual drug spending  represents the aggregate drug expenditure  managed
by us whether or not we dispensed the drugs through our pharmacy  networks,  our
mail pharmacy service  operations,  or through  pharmacy  networks and formulary
programs we administer for our clients.  

     (4)EBITDA   is  earnings   before   interest,   taxes,   depreciation   and
amortization,  and corporate  restructuring  (operating income plus depreciation
and amortization and corporate restructuring). EBITDA is presented because it is
a  widely  accepted  indicator  of a  company's  ability  to incur  and  service
indebtedness. EBITDA, however, should not be considered as an alternative to net
income, as a measure of operating performance, as an alternative to cash flow or
as a measure of  liquidity.  In addition,  our  definition  of EBITDA may not be
comparable to similar measures reported by other companies.
</FN>
</TABLE>

ITEM 7 - MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND 
         RESULTS OF OPERATIONS
 
OVERVIEW

     During  1998,  the  Company  continued  executing  its growth  strategy  of
generating  sales to new clients,  expanding  the services  provided to existing
clients,  developing new products and services for sale to existing  clients and
pharmaceutical manufacturers and selectively pursuing strategic acquisitions and
alliances. On April 1, 1998, the Company consummated its first major acquisition
by  acquiring   "ValueRx",   the  PBM  operations  of  Columbia/HCA   Healthcare
Corporation ("Columbia"), for approximately $460 million in cash, which included
transaction  costs and executive  severance costs of approximately  $6.7 million
and $8.3  million,  respectively.  Specifically,  the Company  acquired  various
subsidiaries  of  Columbia  each now or formerly  conducting  business as a PBM,
including ValueRx Pharmacy Program, Inc. The acquisition was accounted for under
the purchase method of accounting. Consequently, the Company's operating results
include those of ValueRx from April 1, 1998.  The net assets  acquired have been
preliminarily  recorded at their estimated fair value, resulting in $289,863,000
of goodwill which is being amortized over 30 years.

     The  acquisition of ValueRx  enabled the Company to increase  membership to
approximately 22.9 million lives as of December 31, 1998 from approximately 12.6
million lives as of December 31, 1997,  representing an 81.7% increase. In 1997,
the Company  increased  membership by  approximately  2.7 million lives from 9.9
million  lives as of December  31,  1996,  representing  a 27.3%  increase.  The
increase in membership in 1997 was primarily due to internal growth.  Reflecting
the addition of new clients  implemented  at January 1, 1999,  the Company's net
membership increased approximately 600,000 to approximately 23.5 million lives.

     The Company primarily derives its revenues from the sale of PBM services in
the United States and Canada.  The Company's PBM net revenues  generally include
administrative  fees,  dispensing fees and ingredient  costs of  pharmaceuticals
dispensed from retail  pharmacies  included in one of the Company's  networks or
from one of the Company's mail  pharmacies  and records the associated  costs in
cost of revenues.  Where the Company only administers the contracts  between its
clients and the clients'  retail pharmacy  networks,  the Company records as net
revenues  only the  administrative  fee it  receives  from its  activities.  The
Company  also  derives  PBM net  revenues  from  the sale of  informed  decision
counseling services through its Express Health LineSM division,  and the sale of
medical  information  management  services,  which include  provider  profiling,
disease  management  support services and outcomes  assessments  through its PPS
subsidiary.   Non-PBM  net   revenues   are   derived   from  (i)  the  sale  of
pharmaceuticals  for and the provision of infusion  therapy services through its
IVTx  subsidiary,  (ii) an  administrative  fee received  for members  using the
Company's vision program through its alliance with Cole Managed Vision ("Cole"),
a  subsidiary  of Cole  National  Corporation,  and  (iii)  administrative  fees
received from drug manufacturers for the dispensing of  pharmaceuticals  through
its Specialty Distribution division.

RESULTS OF OPERATIONS

NET REVENUES
<TABLE>
                                  YEAR ENDED DECEMBER 31,
<CAPTION>

(IN THOUSANDS)     1998        INCREASE       1997        INCREASE      1996
<S>           <C>               <C>     <C>                 <C>     <C>        
- -------------------------------------------------------------------------------
PBM           $   2,765,111     132.1%  $    1,191,173      60.3%   $   743,077
Non-PBM              59,761      51.4%          39,461      29.2%        30,538
                ---------------------------------------------------------------
Net revenues  $   2,824,872     129.5%  $    1,230,634      59.1%   $   773,615
                ===============================================================
</TABLE>

     The Company experienced  significant growth in its net revenues during 1998
over 1997  primarily due to the  acquisition of ValueRx and, to a lesser extent,
the  Company's  continuing  ability to attract new clients as well as additional
members from  existing  clients.  Net revenues for the network  pharmacy  claims
services  increased  $1,175,659,000,  or 141.7%, in 1998 over 1997 and increased
$311,195,000,  or 60.0%,  in 1997 over 1996.  These  increases are the result of
growth in the number of network  pharmacy claims processed of 54.7% in 1998 over
1997 and of 26.5% in 1997 over 1996,  and an increase in the average net revenue
per network  pharmacy  claim of 56.3% in 1998 over 1997 and an increase of 26.6%
in 1997 over 1996.  The  increase in average  net  revenue per network  pharmacy
claim for both periods is primarily due to the following  factors:  (i) a larger
number of clients  using retail  pharmacy  networks  established  by the Company
rather than retail pharmacy networks  established by our clients,  which results
in the Company  recording  dispensing fees and ingredient  costs in net revenues
and cost of revenues, and (ii) higher drug ingredient costs resulting from price
increases for existing  drugs,  new drugs  introduced  into the  marketplace and
changes in therapeutic mix and dosage.  These increases were partially offset by
lower  pricing  offered by the  Company in  response  to  continued  competitive
pressures.

     The number of clients using retail  pharmacy  networks  established  by the
Company increased  significantly  beginning in the second quarter of 1998 due to
the acquisition of ValueRx, as substantially all ValueRx clients used the retail
pharmacy  networks  established  by ValueRx.  As a result of this  shift,  gross
margin  percentages are reduced but the dollar amount of the gross profit is not
significantly affected.

     Net revenues for mail pharmacy services increased $385,149,000,  or 109.6%,
in 1998 over 1997 and $129,273,000, or 58.2%, in 1997 over 1996. These increases
are the result of the growth in mail pharmacy claims  processed of 90.5% in 1998
over  1997 and 40.8% in 1997 over  1996,  and an  increase  in the  average  net
revenue  per mail  pharmacy  claim of 10.0% in 1998  over 1997 and 12.4% in 1997
over 1996.  The increase in the average net revenue per mail pharmacy  claim for
both periods is primarily due to the following  factors:  (i) the termination of
inventory replacement programs maintained for two large clients during 1997; and
(ii) higher drug  ingredient  costs.  These  increases were partially  offset by
lower  pricing  offered by the  Company in  response  to  continued  competitive
pressures.

     Under the inventory replacement programs offered in 1996 and the first four
months of 1997,  the client  provided drug inventory on consignment to fill mail
service prescriptions for members of the client's plan, and the Company included
only its  dispensing  fee as net  revenue.  For 1998 and most of 1997,  all mail
pharmacy  clients  utilized the Company's  standard program in which the Company
purchases and takes title to the inventory used to fill the  prescriptions  and,
therefore,  includes the ingredient  costs as well as the dispensing fees in net
revenues. This change had the effect of increasing both net revenues and cost of
revenues during 1998 and 1997 compared to 1997 and 1996, respectively, but there
was no significant effect on the Company's reported gross margin during 1998 and
1997 from the  conversion to the standard  program.  In addition,  the Company's
inventory  levels increased  substantially  during 1997 over 1996 as a result of
the termination of the inventory replacement program.

     Net revenues for the Company's  non-PBM  services  increased  51.4% in 1998
over 1997 and 29.2% in 1997 over 1996. The increases are primarily  attributable
to the  continued  growth in the number of members  and/or  clients  who receive
these  services,  higher  drug  ingredient  costs and the  Company's  ability to
develop new products and services.

COST AND EXPENSES
<TABLE>
                                              YEAR ENDED DECEMBER 31,
<CAPTION>

(IN THOUSANDS)                        1998        INCREASE       1997        INCREASE       1996
<S>                                 <C>             <C>       <C>              <C>       <C>     
- -------------------------------------------------------------------------------------------------
PBM                                 $ 2,540,360     133.4%    $1,088,225       64.4%     $661,946
 Percentage of pbm net revenues           91.9%                    91.4%                    89.1%
Non-PBM                                  44,637      44.3%        30,942       34.9%     $ 22,936
 Percentage of non-pbm net                74.7%                    78.4%                    75.1%
 revenues
                                    -------------------------------------------------------------
Cost of revenues                      2,584,997     131.0%     1,119,167      63.4%     $684,882
 Percentage of net revenues               91.5%                    90.9%                   88.5%

Selling, general and administrative     130,116     127.2%         57,257     23.8%       46,267
 Percentage of net revenues                4.6%                      4.7%                   6.0%

Depreciation and amortization (1)        18,874     252.1%          5,360     89.0%        2,836
 Percentage of net revenues                0.7%                      0.4%                   0.4%

Corporate restructuring expense           1,651       NM               -        NM            - 
 Percentage of net revenue                 0.0%                      0.0%                   0.0%
                                    =============================================================
Total cost and expenses             $ 2,735,638     131.5%    $ 1,181,784     61.0%     $733,985
                                    =============================================================
 Percentage of net revenues               96.8%                     96.0%                   94.9%

<FN>
     (1) Represents  depreciation and amortization  expense included in selling,
general and  administrative  expenses on the Company's  Statement of Operations.
Cost of revenues,  above,  includes  depreciation  and  amortization  expense on
property, plant and equipment. nm = not meaningful

</FN>
</TABLE>

     The Company's  cost of revenues for PBM services as a percentage of PBM net
revenues   continued   to  increase  in  1998  and  1997  over  1997  and  1996,
respectively.  Cost of revenues for the Company's  pharmacy  network  claims and
mail pharmacy claims increased 145.5% and 106.7% during 1998 and 65.7% and 60.2%
during  1997,  respectively.  The PBM gross  margin as a  percentage  of PBM net
revenues declined 0.5 percentage points during 1998 over 1997 and 2.3 percentage
points during 1997 over 1996. The decrease in gross margin percentage in 1997 is
due to the shift  towards  pharmacy  networks  established  by the  Company,  as
opposed to those  established by its clients,  higher drug ingredient  costs and
the  termination of the inventory  replacement  programs,  as discussed above in
"--Net  Revenues." The decrease in gross margin  percentage in 1998 is primarily
due to the shift  towards  pharmacy  networks  established  by the Company.  The
pharmacy  network shift  continued  due to the  acquisition  of ValueRx,  as the
ValueRx clients primarily used retail pharmacy networks  established by ValueRx.
This decrease was  partially  offset by operating  efficiencies  achieved in the
Company's mail pharmacies during 1998 and revenues generated from integrated PBM
services,  such as medical and drug data  analysis,  that  provide  higher gross
margins.

     Cost of revenues for non-PBM services  decreased as a percentage of non-PBM
net revenues from 1997 primarily due to the Company developing new business that
generates higher gross margins. These higher gross margins were partially offset
by increasing  costs associated with continued  expansion of certain  operations
and continued  change in the product mix sold in 1998 compared to 1997.  Cost of
revenues for non-PBM services  increased as a percentage of non-PBM net revenues
in 1997 over 1996 primarily due to increasing  costs  associated  with continued
expansion of certain operations.

     Selling,  general and  administrative  expenses increased  $72,859,000,  or
127.2%,  in 1998 over 1997 and  $10,990,000,  or 23.8%,  in 1997 over 1996.  The
increase  during 1998 was the result of the  Company's  acquisition  of ValueRx,
costs  incurred  during the  integration of ValueRx and costs required to expand
the operational and  administrative  support functions to enhance  management of
the  pharmacy  benefit.  The  increase  during  1997  was  primarily  due to the
expansion of the operational  and  administrative  support  functions to enhance
management of the pharmacy  benefit.  As a percentage of net revenues,  selling,
general and  administrative  expenses for 1998  decreased  slightly to 4.6% from
4.7% in 1997.  In 1997,  selling,  general  and  administrative  expenses,  as a
percentage of net revenues,  decreased 1.3 percentage  points from 6.0% in 1996.
Selling,  general and administrative  expenses, as a percentage of net revenues,
in both periods were affected by the Company  recording  higher net revenues due
to the shift towards pharmacy networks established by the Company, as opposed to
those   established  by  its  clients  and  the  termination  of  the  inventory
replacement programs, as discussed above for "Net Revenues."

     As part of its overall plan to achieve operating economies, the Company has
been integrating ValueRx into its historical business.  During 1998, the Company
substantially  met its  integration  goals by combining  existing  contracts and
contracting  procedures  related to both  suppliers and  providers;  integrating
financial reporting systems,  reducing the ValueRx computer systems from five to
three,   consolidating   financial  operations,   consolidating   organizational
structure  and employee  benefits,  and  implementing  a new sales and marketing
program for enhanced  PBM  services.  The Company  expects to reduce the ValueRx
computer  systems to one by  October,  1999.  Except  for  certain  new  systems
development costs, the Company is expensing integration costs as incurred.

     Depreciation and amortization substantially increased during 1998 over 1997
due  to  the  acquisition  of  ValueRx.   During  1998,  the  Company   recorded
amortization  expense for goodwill and other  intangible  assets of $12,183,000.
The  remaining  increases  in 1998  and 1997 are  primarily  due to the  Company
expanding its operations and enhancing its information  systems to better manage
the pharmacy benefit.

     On June 17, 1998,  the Company  announced  that it had reached an agreement
with Cole,  pursuant to which Cole will provide certain vision care services for
the Company's  clients and their members.  The agreement  enables the Company to
focus on its PBM  business  while still  offering  vision  care  services to its
members by  transferring  certain  functions  performed  by its Express  Scripts
Vision Corporation to Cole, effective September 1, 1998. In conjunction with the
agreement,  the Company  also  announced  plans to close the  operations  of its
wholly-owned  subsidiary,  PhyNet,  Inc., a vision program  management  services
organization As a result, the Company recorded a one-time  restructuring  charge
of $1,651,000 in 1998 comprised of asset  write-downs of $1,235,000 and expected
employee transition cash payments of $416,000 for 61 employees. During 1998, the
Company incurred cash payments of $184,000 for employee  transition and non cash
adjustments  of $704,000 for the write-down of assets.  The Company  anticipates
completing  the remainder of the  restructuring  transactions  by the end of the
third quarter of 1999.

INTEREST INCOME (EXPENSE), NET

<TABLE>
                                           YEAR ENDED DECEMBER 31,
<CAPTION>
(IN THOUSANDS)                       1998        INCREASE       1997        INCREASE     1996
<S>                              <C>             <C>        <C>           <C>        <C>     
- ----------------------------------------------------------------------------------------------
Interest expense                 $ (20,230)         nm      $ (225)            nm     $   (59)
 Percentage of net revenues           -0.7%                    0.0%                       0.0%

Interest income                       7,236       19.0%       6,081          73.3%       3,509
 Percentage of net revenues            0.2%                    0.5%                       0.5%
                                 -------------------------------------------------------------
Interest income (expense), net   $ (12,994)         nm      $ 5,856          69.7%     $ 3,450
                                 =============================================================
 Percentage of net revenues           -0.5%                    0.5%                       0.5%

nm = not meaningful
</TABLE>

     During 1998, the Company recorded  significant  interest expense  resulting
from the  financing of the ValueRx  acquisition  with $360 million in borrowings
(see "Liquidity and Capital Resources").  Interest income increased  $1,155,000,
or 19.0%,  in 1998 over 1997 and  $2,572,000,  or 73.3% in 1997 over  1996.  The
increases  in  1998  and  1997  are due to the  Company  investing  larger  cash
balances.  In addition, in 1997 the larger cash balances were invested at higher
interest rates than those in 1996.

PROVISION FOR INCOME TAXES
<TABLE>
                                                YEAR ENDED DECEMBER 31,
<CAPTION>
(IN THOUSANDS)                1998        INCREASE       1997        INCREASE       1996
<S>                           <C>          <C>          <C>            <C>        <C>    
- -----------------------------------------------------------------------------------------------
Provision for income taxes    $33,566      57.8%        $21,277        25.7%      $16,932
Effective tax rate              44.0%                     38.9%                     39.3%
</TABLE>

     The  Company's  effective  tax rate  increased in 1998 over 1997 due to the
non-deductible  goodwill and client contract amortization expense resulting from
the  ValueRx  acquisition.  It is  expected  that the  effective  tax rate  will
gradually  decline towards the statutory rate as the Company's  operating growth
continues.

NET INCOME AND EARNINGS PER SHARE

<TABLE>
                                                               YEAR ENDED DECEMBER 31,
<CAPTION>

(IN THOUSANDS)                               1998        INCREASE       1997        INCREASE       1996
<S>                                      <C>               <C>        <C>             <C>        <C>      
- --------------------------------------------------------------------------------------------------------------
Net income                               $     42,674      27.7%      $  33,429       27.8%      $  26,148
    Percentage of net revenue                    1.5%                      2.7%                       3.4%

Basic earnings per share                 $       1.29      26.5%      $    1.02       25.9%      $    0.81

Weighted average shares outstanding            33,105       1.2%         32,713        1.7%         32,160

Diluted earnings per share               $       1.27      25.7%      $    1.01       26.3%           0.80

Weighted average share outstanding             33,698       1.7%         33,122        1.3%         32,700

</TABLE>

     The Company's net income  increased  $9,245,000 or 27.7% in 1998 over 1997,
and  $7,281,000 or 27.8% in 1997 over 1996.  Excluding  the  after-tax  one-time
corporate  restructuring  charge for the managed vision  business of $1,002,000,
basic earnings per share and diluted earnings per share for 1998 would have been
$1.32 and $1.30, respectively.

     On October 12, 1998, the Company announced a two-for-one stock split of its
Class A and Class B Common Stock for stockholders of record on October 20, 1998,
effective  October 30, 1998. The split was effected in the form of a dividend by
issuance of one additional share of Class A Common Stock for each share of Class
A Common Stock  outstanding and one additional share of Class B Common Stock for
each share of Class B Common Stock  outstanding.  The earnings per share and the
weighted average number of shares outstanding for basic and diluted earnings per
share for each period have been adjusted for the stock split.

LIQUIDITY AND CAPITAL RESOURCES
<TABLE>
                                                               YEAR ENDED DECEMBER 31,
<CAPTION>

(IN THOUSANDS)                               1998        INCREASE       1997        INCREASE       1996
<S>                                       <C>             <C>         <C>           <C>         <C>    
- --------------------------------------------------------------------------------------------------------------
Net cash provided by operations           $126,574        141.1%      $ 52,503      75.8%       $29,863
</TABLE>

     The  increase in  operating  cash flow  generated in 1998 by the Company is
primarily due to the increase in net income and its continued focus on improving
working  capital  management.  The increase in operating  cash flow generated in
1997 is primarily  due to the  increase in net income and the Company  beginning
its working capital  management focus. The operating cash flow generated in 1996
is primarily due to the increase in net income.  Management  expects to fund its
future  debt  service,  integration  costs,  Year 2000  costs  and other  normal
operating cash needs  primarily with operating cash flow or with working capital
borrowings  under the $1.1 billion credit facility the Company intends to obtain
in connection with the DPS acquisition (see below).

     The Company's capital  expenditures in 1998 increased  $10,836,000 or 83.2%
over  1997  primarily  due to the  Company's  concerted  effort to invest in its
information  technology  to enhance the  services  provided to its  clients.  In
addition,  the Company  invested in equipment to improve  efficiency at its mail
pharmacy facilities and to manage the growth encountered at these facilities. In
1997, capital  expenditures  increased  $3,537,000 or 37.3% primarily due to the
investments required for the Company to manage its growth. Management expects to
continue  investing  in  technology  that  will  provide   efficiencies  in  its
operations,  manage its growth and enhance the service  provided to its clients.
Management expects to fund its future anticipated capital expenditures primarily
with  operating  cash flow or with  working  capital  borrowings  under the $1.1
billion credit facility the Company intends to obtain in connection with the DPS
acquisition (see below).

     During the first  quarter of 1998,  the Company  negotiated  a $440 million
credit  facility  with a  bank  syndicate  led by  Bankers  Trust  Company.  The
five-year  agreement became effective April 1, 1998, and included a $360 million
term loan facility and an $80 million  revolving  loan  facility.  The term loan
proceeds were utilized to consummate the  acquisition of ValueRx.  The agreement
is  guaranteed  by the  Company's  domestic  subsidiaries  other  than  Practice
Patterns  Science,  Inc.  ("PPS") and Great Plains  Reinsurance  Company ("Great
Plains")   and  secured  by  pledges  of  100%  (or,  in  the  case  of  foreign
subsidiaries, 65%) of the capital stock of the Company's subsidiaries other than
PPS and Great Plains.  The provisions of this credit facility require  quarterly
interest payments and, beginning in April 1999,  semi-annual  principal payments
of $27 million, increasing to $36 million in April 2000, to $45 million in April
2001 and to $48 million in April 2002.  The  interest  rate is based on a spread
(the "Credit Rate Spread") over several London Interbank Offered Rates ("LIBOR")
or base rate  options,  depending  upon the Company's  ratio of earnings  before
interest,  taxes,  depreciation  and amortization to debt. At December 31, 1998,
the interest rate was 6.0625%,  representing  a Credit Rate Spread of 0.75% over
the three-month LIBOR rate. This credit facility contains  covenants that limit:
(i) the indebtedness the Company may incur, and (ii) the amount of the Company's
annual  capital  expenditures.  The  covenants  also  establish:  (i) a  minimum
interest  coverage ratio,  (ii) a maximum  leverage  ratio,  and (iii) a minimum
consolidated net worth. At December 31, 1998, the Company was in compliance with
all  covenants.  In  addition,  the  Company is  required  to pay an annual fee,
depending  on the leverage  ratio,  payable in  quarterly  installments,  on the
unused portion of the revolving  loan. The commitment fee was 0.225% at December
31,  1998.  As a result of this credit  facility,  the Company  canceled its $25
million line of credit with Mercantile Bank of St. Louis on March 31, 1998.

     In connection  with its acquisition of DPS, the Company intends to obtain a
$1.1 billion  credit  facility from a bank  syndicate led by Credit Suisse First
Boston and Bankers Trust Company and a $150 million senior  subordinated  bridge
credit  facility from Credit Suisse First Boston and Bankers Trust Company.  The
proceeds  of the  facilities  will be used to  purchase  DPS and retire the $440
million  credit  facility with Bankers Trust  Company.  The $1.1 billion  credit
facility would also provide a revolving  line of credit to meet working  capital
needs. In addition,  the Company expects to issue $350 million in Class A Common
Stock through an offering.  The proceeds from the offering will be used to repay
the $150  million  subordinated  bridge  credit  facility  and a portion  of the
intended $1.1 billion credit facility.

     To alleviate  interest rate  volatility in connection with its $440 million
credit facility,  the Company entered into an interest rate swap arrangement for
a notional  principal amount of $360 million effective April 3, 1998, with First
National Bank of Chicago, a subsidiary of Bank One Corporation.  Under the terms
of the swap,  the Company  agreed to receive a floating  rate of interest on the
amount of the term loan portion of the  facility  based on a  three-month  LIBOR
rate in exchange for payment of a fixed rate of interest of 5.88% per annum. The
notional  amount of the swap is  amortized in equal  amounts with the  principal
balance of the term loan. As a result, the Company had, in effect, converted its
variable  rate  term debt to fixed  rate debt at 5.88% per annum for the  entire
term of the term loan,  plus the Credit Rate  Spread.  The  Company  anticipates
maintaining  its  interest  rate  swap in  place to hedge  the  future  variable
interest  rate  payments on $360  million of the intended  $1.1  billion  credit
facility.

     As of December 31,  1998,  the Company had  repurchased  a total of 475,000
shares  of its  Class A Common  Stock  under the  open-market  stock  repurchase
program  announced by the Company on October 25, 1996,  although no  repurchases
occurred during 1998. The Company's  Board of Directors  approved the repurchase
of up to  1,700,000  shares and placed no limit on the  duration of the program.
Future  purchases,  if any,  will be in such  amounts  and at such  times as the
Company deems appropriate based upon prevailing market and business  conditions,
subject to certain  restrictions  in the Company's  intended $1.1 billion credit
facility.

     The Company  has  reviewed  and  intends to  continue  to review  potential
acquisitions and affiliation opportunities.  The Company believes that available
cash resources,  bank financing or the issuance of additional common stock could
be used to finance such acquisitions or affiliations.  There can be no assurance
the Company will make other acquisitions or affiliations in 1999 or thereafter.

OTHER MATTERS

     On March 16, 1998,  the Company  announced  that,  in  connection  with the
consummation of the sale by New York Life Insurance Company ("New York Life") of
NYLCare Health Plans, Inc.  ("NYLCare") to Aetna U.S.  Healthcare Inc. ("Aetna")
(which  occurred  on July 15,  1998),  the  Company  and  Aetna had  reached  an
agreement to extend the  Company's  PBM services and infusion  therapy  services
agreements to HMO members  through  December 31, 2003. The existing PBM contract
pricing is effective  through December 31, 1999, and thereafter  certain pricing
adjustments  (which the Company  believes  reflect an appropriate  market price)
will be  instituted  for the year 2000 and  subsequent  periods.  The  agreement
between Aetna and the Company provides that the Company will continue  providing
PBM services,  excluding informed decision counseling  services,  to 1.4 million
HMO members through 2003, which is comparable to the NYLCare HMO membership base
served by the  Company  prior to the Aetna  acquisition.  The  infusion  therapy
agreements  are extended  under their current terms until December 31, 2000, and
thereafter   limited   price   adjustments   may  take  effect   under   certain
circumstances.  The  existing  agreements  for managed  vision care and informed
decision  counseling  will continue until December 31, 1999. The Company expects
to continue  providing PBM services to members of the NYLCare indemnity programs
until such members are  converted  to new health  insurance  policies,  which is
anticipated  to occur  primarily  during  1999.  In  connection  with the  Aetna
arrangement,  the  Company  and New York  Life  have  reached  an  agreement  in
principle whereby New York Life may make certain transition-related  payments to
the  Company in 1999.  This  agreement  is subject to the  approval of the Audit
Committee  of the  Company's  Board of  Directors.  The  overall  impact of this
arrangement on earnings per share is not expected to be material in 1999.

     During 1998 and 1997,  4.8% and 15.7%,  respectively,  of the Company's PBM
net revenues were from services  provided to members of HMOs owned or managed by
NYLCare or  insurance  policies  administered  by NYLCare  while it was a wholly
owned  subsidiary  of New York Life.  Of the  Company's net revenues for non-PBM
services,  21.5%  and 54.8% in 1998 and 1997,  respectively,  were for  services
provided  to members of HMOs owned or managed by NYLCare or  insurance  policies
administered by NYLCare while it was a wholly owned subsidiary of New York Life.

     Effective with the first quarter of 1998, the Company adopted  Statement of
Financial  Accounting  Standards Statement 130, Reporting  Comprehensive  Income
("FAS 130").  FAS 130 requires  noncash  changes in  stockholders'  equity to be
combined  with net income and  reported in a new  financial  statement  category
entitled  comprehensive  income.  Other than net income,  the only  component of
comprehensive  income  for the  Company is the  change in the  foreign  currency
translation account.

     Effective  with fiscal  year end 1998,  the Company  adopted  Statement  of
Financial  Accounting  Standards Statement 131, Disclosures About Segments of an
Enterprise  and Related  Information  ("FAS  131").  FAS 131  requires  that the
Company  report  certain  information  if  specific  requirements  are met about
operating  segments  of  the  Company,  including  information  about  services,
geographic  areas of operation and major  customers.  The  information  is to be
derived from the management approach, which designates the internal organization
that is  used  by  management  for  making  operating  decisions  and  assessing
performance as the source of the Company's operating  segments.  Adoption of FAS
131 did not affect the Company's results of operations or its financial position
but did affect the  disclosure of segment  information  (see Note 13 in our 1998
Consolidated Financial Statements).

     In June 1998,  Statement of Financial  Accounting  Standards Statement 133,
Accounting for Derivative  Instruments  and Hedging  Activities  ("FAS 133") was
issued.  FAS 133 requires all  derivatives  to be recognized as either assets or
liabilities  in the statement of financial  position and measured at fair value.
In addition, FAS 133 specifies the accounting for changes in the fair value of a
derivative  based  on the  intended  use of the  derivative  and  the  resulting
designation.  FAS 133 is  effective  for all  fiscal  quarters  of fiscal  years
beginning  after June 15, 1999,  and will be applicable  to the Company's  first
quarter of fiscal  year 2000.  The  Company's  present  interest  rate swap (see
"--Liquidity  and Capital  Resources")  would be  considered  a cash flow hedge.
Accordingly,  the change in the fair value of the swap would be  reported on the
balance sheet as an asset or liability.  The  corresponding  unrealized  gain or
loss  representing  the  effective  portion  of  the  hedge  will  be  initially
recognized  in  stockholders'   equity  and  other   comprehensive   income  and
subsequently any changes in unrealized gain or loss from the initial measurement
date will be recognized in earnings  concurrent with the interest expense on the
Company's  underlying  variable rate debt. If the Company had adopted FAS 133 as
of December 31, 1998,  the Company  would have recorded the  unrealized  loss of
$7,209,000  as a  liability  and  reduction  in  stockholders'  equity and other
comprehensive income.

POST YEAR-END EVENTS

     On February 1, 1999, the Company announced a three-and-a-half-year contract
with Blue Cross and Blue Shield of  Massachusetts  ("BCBSMA").  Beginning in the
second half of 1999,  the Company will provide  retail network and mail pharmacy
services,  claims  processing,  clinical  management  support and other  related
services to approximately 1.2 million BCBSMA members.

     On February 9, 1999,  the Company  announced  its  definitive  agreement to
acquire  DPS for $700  million in cash.  The  Company  intends  to  finance  the
acquisition through its $1.1 billion credit facility and its $150 million senior
subordinated  bridge credit facility (see "--Liquidity and Capital  Resources").
The  acquisition  will be accounted for under the purchase  method of accounting
and is subject to customary  closing  conditions and consummation and funding of
the  committed  bank  credit  facility  and senior  subordinated  bridge  credit
facility.  The  Company  anticipates  the  transaction  will close in the second
quarter  of 1999 and  expects  to issue  $350  million  in Class A Common  Stock
through a public  offering.  The net  proceeds of the  offering  will be used to
repay the senior subordinated bridge credit facility and a portion of the credit
facility.

YEAR 2000

     The Company's  operations  rely heavily on computers and other  information
systems  technologies.  In 1995,  the Company began  addressing  the "Year 2000"
issue,  which refers to the  inability of certain  computer  systems to properly
recognize  calendar dates beyond  December 31, 1999.  This arises as a result of
systems having been programmed with two digits rather than four digits to define
the applicable  year in order to conserve  computer  storage  space,  reduce the
complexity of calculations and produce better performance.  The two-digit system
may cause  computers to interpret the year "00" as "1900" rather than as "2000",
which may cause system failures or produce  incorrect  results when dealing with
date-sensitive information beyond 1999.

     The Company  formed a Year 2000 task force to address this issue.  The task
force has  performed a  self-assessment  and  developed a  compliance  plan that
addresses,   in  light  of  applicable  industry  standards,   the  testing  and
modification  of: (i) internally  developed  application  software,  (ii) vendor
developed  application software,  (iii) operating system software,  (iv) utility
software,  (v) vendor/trading  partner-supplied  files, (vi) externally provided
data or  transactions,  and (vii)  non-information  technology  devices that are
material  to the  Company's  business.  Progress in each area is  monitored  and
management reports are given periodically.

     The  Company  has  various  applications  and  operating  systems  that are
considered  critical to its operations.  Approximately 75% of these systems have
been  tested  in  an  integrated  environment  by  the  Company  for  Year  2000
compliance.  The  remaining  systems  will either be tested  and, if  necessary,
modified  to be  compliant  by  the  end of  the  second  quarter  of  1999,  or
information  residing  on such  systems  will  be  integrated  into a Year  2000
compliant  operating  system.  Testing of the applications and operating systems
includes the  adjudication  process,  the eligibility  process,  the billing and
remittance  process,  the  communication  process  and  the  reporting  process,
including  financial  reporting.  In addition,  since 1995,  all new  internally
developed  software  has been  developed to be Year 2000  compliant  and will be
fully tested during the remainder of 1999.

     The Company is  participating  in a joint  effort  with other PBMs,  retail
pharmacy chains, transaction routing companies and adjudication software vendors
to test Year 2000  compliance.  The joint  effort is called the "Y2K  Provider &
Vendor  Testing  Coalition"  and is being  facilitated  by The  National  Health
Information  Network.  The  coalition  has the  support  of  major  U.S.  retail
pharmacies,  including  American  Stores,  CVS, Eckerd,  Rite-Aid,  Wal-Mart and
Walgreens.  The inclusion of transaction  routing vendors and software companies
could permit up to 95% of the Company's  pharmacy network to be tested (although
there can be no assurance that all parties who are invited to  participate  will
actually participate).  The program will allocate the retail pharmacy chains and
software  vendors  among  the  various  PBMs  who will be  required  to test the
vendors' and pharmacy chains' Year 2000  compliance.  The testing is expected to
be completed during the third quarter of 1999.

     The  Company  has  sent  out   approximately   1,500  letters  to  critical
vendor/trading  partners  requesting a status report  regarding  their Year 2000
compliance.  The Company has received  responses from approximately 30% of these
third parties, with the majority of the vendor/trading  partners responding that
they are  currently  addressing  the Year 2000 issue and expect to be compliant.
The  Company is  formulating  a list of  vendor/trading  partners  that have not
responded in order to send second requests.

     The Company has also contacted several hundred clients and several thousand
pharmacies  whose  computer  systems  appear to the  Company not to be Year 2000
compliant  in an effort to increase  awareness  of the  problem and  minimize or
eliminate any disruption in data transfer  activity between such parties and the
Company.  The Company has developed date windowing  logic which it believes will
address many issues  concerning  retail pharmacies and clients with noncompliant
systems.  Due to the Company's  contracts typically extending over several years
and the Company  receiving  member  eligibility  information  from  clients that
reflect dates beyond the Year 2000, the Company has been  receiving  information
that would identify certain Year 2000 issues for several years. Any problems the
Company  has  encountered  to date  have been  rectified  by the  client  or, if
necessary,  by the Company using the Company's  windowing logic. There can be no
assurance, however, that all such problems that may be encountered in the future
can be rectified with the windowing logic.

     In  addressing  the Year 2000 issue,  the Company has and will  continue to
incur  internal  staff costs as well as external  consulting  and other expenses
related to  infrastructure  enhancements.  To date,  the  Company  has  incurred
approximately $3,500,000 addressing the Year 2000 issue. The Company anticipates
spending an additional  $750,000 to $1,000,000  during 1999  addressing the Year
2000 issue.  All  expenditures  are being expensed as incurred.  To date,  these
costs  have not had a  material  adverse  effect  on the  Company's  results  of
operations  or  financial  condition,  and are not  expected  to have a material
adverse  effect on the  Company's  future  results of  operations  or  financial
condition.

     The Company  believes  that,  with  appropriate  modifications  to existing
computer systems,  updates by vendors and trading partners and conversion to new
software  in the  ordinary  course of its  business,  the Year 2000 issue is not
likely to pose significant operational problems for the Company. However, if the
above-described  conversions  are not completed in a proper and timely manner by
all  affected  parties,  or  if  the  Company's  logic  for  communicating  with
noncompliant  systems  is  ineffective,  the Year  2000  issue  could  result in
material adverse  operational and financial  consequences to the Company.  There
can be no assurance that the Company's efforts,  or those of vendors and trading
partners (who are beyond the Company's control) will be successful in addressing
the Year 2000 issue.

     The  Company is in the  process of  formalizing  its  contingency  plans to
address  potential Year  2000-related  risks,  including risks of vendor/trading
partner noncompliance, as well as noncompliance of any of the Company's critical
operations,  and is expected  to be  substantially  completed  by the end of the
second quarter of 1999.  However,  the formalization of the contingency plans is
an ongoing  process as the Company  completes  its testing and receives  updates
from  vendor/trading  partners.  There can be no  assurance  that the  Company's
contingency  plans will  successfully  address all  potential  circumstances  or
consequences.

IMPACT OF INFLATION

     Changes  in  prices   charged  by   manufacturers   and   wholesalers   for
pharmaceuticals  affect the Company's net revenues and cost of revenues. To date
the Company has been able to recover price  increases from its clients under the
terms of its agreements.  As a result, changes in pharmaceutical prices have not
had a significant adverse affect on the Company.

MARKET RISK

     To alleviate  interest rate volatility in connection with its existing $440
million  credit  facility,  the  Company  entered  into an  interest  rate  swap
arrangement for a notional  principal amount of $360 million  effective April 3,
1998,  with First  National  Bank of Chicago.  Under the swap  arrangement,  the
Company  agreed to receive a floating rate of interest on an amount equal to the
outstanding  principal  balance of the term loan portion of the credit  facility
based on a  three-month  LIBOR rate in  exchange  for payment of a fixed rate of
interest of 5.88% per annum on such amount.  The weighted  average variable rate
received by the Company for the period April 3, 1998 to December  31, 1998,  was
5.5729%.  The notional  amount of the swap  amortizes in equal  amounts with the
principal  balance of the term  loan.  The swap  expires  on April 3,  2003.  At
December 31, 1998, the fair value of the swap was ($7,209,000).

     Interest  rate risk is  monitored on the basis of changes in the fair value
and a sensitivity analysis is used to determine the impact interest rate changes
will have on the fair value of the interest  rate swap,  measuring the change in
the net present  value  arising from the change in the interest  rate.  The fair
value of the swap is then  determined  by  calculating  the present value of all
cash-flows  expected  to arise  thereunder,  with  future  interest  rate levels
implied from prevailing mid-market yields for money-market instruments, interest
rate futures and/or prevailing mid-market swap rates. Anticipated cash-flows are
then  discounted on the  assumption of a  continuously  compounding  zero-coupon
yield curve.  A 10% decline in interest  rates at December 31, 1998,  would have
caused  the fair  value of the swap to  decrease  by an  additional  $3,812,000,
resulting in a fair value of ($11,021,000).

ITEM 7A.  QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK.

     Response to this item is included in Item 7  "Management's  Discussion  and
Analysis of Financial Condition and Results of Operations--Market Risk" above.


ITEM 8 - CONSOLIDATED FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

                        REPORT OF INDEPENDENT ACCOUNTANTS


To the Board of Directors and
Stockholders of Express Scripts, Inc.


     In our opinion,  the consolidated  financial statements listed in the index
appearing  under  Item  14(a)(1)  on  page 60  resent  fairly,  in all  material
respects,  the financial position of Express Scripts,  Inc. and its subsidiaries
at December  31, 1998 and 1997,  and the results of their  operations  and their
cash flows for each of the three years in the period ended December 31, 1998, in
conformity with generally accepted accounting  principles.  In addition,  in our
opinion,  the financial  statement  schedule listed in the index appearing under
Item  14(a)(2)  on  page 60  presents  fairly,  in all  material  respects,  the
information  set  forth  therein  when  read in  conjunction  with  the  related
consolidated  financial  statements.  These  financial  statements and financial
statement  schedule are the  responsibility  of the  Company's  management;  our
responsibility  is to  express  an opinion  on these  financial  statements  and
financial  statement  schedule  based on our audits.  We conducted our audits of
these statements in accordance with generally  accepted auditing standards which
require that we plan and perform the audit to obtain reasonable  assurance about
whether the financial  statements  are free of material  misstatement.  An audit
includes  examining,  on a test  basis,  evidence  supporting  the  amounts  and
disclosures in the financial  statements,  assessing the  accounting  principles
used and  significant  estimates made by management,  and evaluating the overall
financial  statement  presentation.   We  believe  that  our  audits  provide  a
reasonable basis for the opinion expressed above.


/s/ PricewaterhouseCoopers LLP
PricewaterhouseCoopers LLP
St. Louis, Missouri
February 12, 1999
<PAGE>


CONSOLIDATED BALANCE SHEET
- -------------------------------------------------------------------------------
<TABLE>                                                                         
<CAPTION>

                                                                                               DECEMBER 31,
(IN THOUSANDS, EXCEPT SHARE DATA)                                                       1998                1997
<S>                                                                                   <C>               <C>            
- ----------------------------------------------------------------------------------------------------------------------
Assets
Current assets:
    Cash and cash equivalents                                                         $     122,589     $        64,155
    Short-term investments                                                                                       57,938
    Receivables, less allowance for doubtful
        accounts of $17,806 and $4,802, respectively
            Unrelated parties                                                               433,006             194,061
            Related parties                                                                                      16,230
    Inventories                                                                              55,634              28,935
    Deferred taxes                                                                           41,011               2,303
    Prepaid expenses                                                                          4,667                 346
                                                                                  --------------------------------------
            Total current assets                                                            656,907             363,968
                                                                                  --------------------------------------
Property and equipment, less accumulated depreciation and amortization                       77,499              26,821
Goodwill, less accumulated amortization                                                     282,163                 251
Other assets                                                                                 78,892              11,468
                                                                                  -------------------------------------
            Total assets                                                               $  1,095,461       $     402,508
                                                                                  =====================================

Liabilities and Stockholders' Equity Current liabilities:
    Current maturities of long-term debt                                             $       54,000       $           -
    Claims and rebates payable                                                              338,251             164,920
    Accounts payable                                                                         60,247              17,979
    Accrued expenses                                                                         86,798              15,007
                                                                                  -------------------------------------
            Total current liabilities                                                       539,296             197,906
Long-term debt                                                                              306,000
Other liabilities                                                                               471                 901
                                                                                  --------------------------------------
    Total liabilities                                                                       845,767             198,807
                                                                                  --------------------------------------

Commitments and Contingencies (Notes 3, 9 and 15)

Stockholders' equity:
    Preferred stock, $.01 par value, 5,000,000 shares
        authorized, and no shares issued and outstanding
    Class A Common Stock, $.01 par value, 75,000,000 shares authorized,
        18,610,000 and 9,238,000 shares issued and outstanding, respectively                    186                  93
    Class B Common Stock, $.01 par value, 22,000,000 shares authorized,
        15,020,000 and 7,510,000 shares issued and outstanding, respectively                    150                  75
    Additional paid-in capital                                                              110,099             106,901
    Accumulated other comprehensive income                                                     (74)                (27)
    Retained earnings                                                                       146,322             103,648
                                                                                  -------------------------------------
                                                                                            256,683             210,690
    Class A Common Stock in treasury at cost, 475,000 shares                                (6,989)             (6,989)
                                                                                  -------------------------------------
            Total stockholders' equity                                                      249,694             203,701
                                                                                  -------------------------------------
            Total liabilities and stockholders' equity                                 $  1,095,461        $    402,508
                                                                                  =====================================

</TABLE>

SEE ACCOMPANYING NOTES TO CONSOLIDATED FINANCIAL STATEMENTS.

<PAGE>


CONSOLIDATED STATEMENT OF OPERATIONS
- -------------------------------------------------------------------------------
<TABLE>                                                                         
<CAPTION>
                                                                       YEAR ENDED DECEMBER 31,
(IN THOUSANDS, EXCEPT PER SHARE DATA)                                1998                1997               1996
<S> <C>                                                              <C>                 <C>                <C>        
- ------------------------------------------------------------------------------------------------------------------------
Net revenues (including $145,758, $208,118 AND
    $152,311, respectively from related parties)                     $ 2,824,872         $ 1,230,634        $   773,615
                                                              ----------------------------------------------------------
Cost and expenses:
    Cost of revenues                                                   2,584,997           1,119,167            684,882
    Selling, general and administrative                                  148,990              62,617             49,103
    Corporate restructuring                                                1,651                   -                  -
                                                              ----------------------------------------------------------
                                                                       2,735,638           1,181,784            733,985
                                                              ----------------------------------------------------------
Operating income                                                          89,234              48,850             39,630
                                                              ----------------------------------------------------------
Interest income (expense):
    Interest income                                                        7,236               6,081              3,509
    Interest expense                                                    (20,230)               (225)               (59)
                                                              ----------------------------------------------------------
                                                                        (12,994)               5,856              3,450
                                                              ----------------------------------------------------------
Income before income taxes                                                76,240              54,706             43,080
Provision for income taxes                                                33,566              21,277             16,932
                                                              ----------------------------------------------------------       
Net income                                                         $      42,674       $      33,429       $     26,148
                                                              ==========================================================
Basic earnings per share                                           $        1.29       $        1.02       $       0.81
                                                              ==========================================================
Weighted average number of common shares
    outstanding during the period - Basic EPS                             33,105              32,713             32,160
                                                              ==========================================================

Diluted earnings per share                                        $         1.27       $        1.01       $       0.80
                                                              ========================================================== 
Weighted average number of common shares outstanding
    during the period - Diluted EPS                                       33,698              33,122             32,700
                                                              ==========================================================
</TABLE>

SEE ACCOMPANYING NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

<PAGE>

CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS' EQUITY
- -------------------------------------------------------------------------------
<TABLE> 
<CAPTION>
                            Number of Shares                                   Amount
                          -------------------    ----------------------------------------------------------------------------------
                                                                                   Accumulated
                          Class A    Class B      Class A    Class B   Additional    Other
                          Common     Common       Common     Common      Paid-in  Comprehensive   Retained    Treasury
(IN THOUSANDS)            Stock       Stock        Stock      Stock      Capital     Income       Earnings      Stock      Total
<C>                          <C>       <C>        <C>       <C>         <C>        <C>           <C>           <C>          <C>   
- ----------------------------------------------    ---------------------------------------------------------------------------------
Balance at December 31,
1995                         4,539     10,500     $     45  $    105    $33,158    $    -        $  44,071        -      $  77,379
                          --------------------    ---------------------------------------------------------------------------------
 Comprehensive income:
    Net income                                                                                      26,148                  26,148
    Other comprehensive
      income,
        Foreign currency 
          translation
          adjustment             -          -            -          -         -          (2)            -           -          (2) 
                          --------------------    ---------------------------------------------------------------------------------
 Comprehensive income            -          -            -          -         -          (2)        26,148          -       26,146
    Conversion of Class B
     Common Stock to  
     Class A Common Stock     2,990    (2,990)           30       (30)
 Issuance of Class A
    Common Stock
     Contractual agreement      227                       2              11,250                                             11,252
     Public offering          1,150                      12              52,580                                             52,592
 Exercise of stock options       68                       1               1,309                                              1,310
 Tax benefit relating to                                                                 
    employee stock options                                                  661                                                661
 Treasury Stock acquired         -          -            -          -         -            -         -           (5,250)   (5,250)
                          -------------------    ---------------------------------------------------------------------------------
Balance at December 31, 
 1996                         8,974     7,510            90         75   98,958          (2)        70,219       (5,250)   164,090
                          -------------------    ---------------------------------------------------------------------------------
 Comprehensive income:
    Net income                                                                                      33,429                  33,429
    Other comprehensive
     income,
       Foreign currency 
        translation
        adjustment               -          -            -           -        -         (25)          -              -        (25)
                           -------------------   ---------------------------------------------------------------------------------
Comprehensive income             -          -            -           -        -         (25)        33,429           -      33,404
   Exercise of stock
    options                     264                       3               4,769                                              4,772
   Tax benefit relating
    to employee stock
    options                                                               3,174                                              3,174
   Treasury Stock acquired       -          -            -           -        -            -          -          (1,739)   (1,739)
                          --------------------   ---------------------------------------------------------------------------------
Balance at December 31,
1997                          9,238      7,510           93         75  106,901         (27)       103,648       (6,989)   203,701
                          --------------------   ---------------------------------------------------------------------------------
Comprehensive income:
   Net income                                                                                       42,674                  42,674
   Other comprehensive
    income,
     Foreign currency 
      translation 
       adjustmenty               -          -            -          -         -         (47)          -             -         (47)
                          --------------------   ---------------------------------------------------------------------------------
Comprehensive income             -          -            -          -         -         (47)        42,674          -       42,627
Issuance of stock
   dividend                   9,239      7,510           92         75    (167)   
Exercise of stock
   options                      133                       1               2,020                                              2,021
Tax benefit relating to
   employee stock options        -          -             -          -    1,345            -          -             -        1,345
                          --------------------   ---------------------------------------------------------------------------------
Balance at December 31,
1998                         18,610     15,020    $     186   $    150 $110,099         (74)       146,322        (6,989)  249,694
                          ====================    ================================================================================

</TABLE>

SEE ACCOMPANYING NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

<PAGE>


CONSOLIDATED STATEMENT OF CASH FLOWS
- -------------------------------------------------------------------------------
<TABLE> 
<CAPTION>

                                                                         YEAR ENDED DECEMBER 31,
(IN THOUSANDS)                                                          1998                1997               1996
<S>                                                                 <C>                 <C>                <C>         
- -----------------------------------------------------------------------------------------------------------------------
 Cash flows from operating activities:
    Net income                                                      $     42,674        $     33,429       $     26,148
    Adjustments to reconcile net income to net
    cash provided by operating activities:
        Depreciation and amortization                                     27,042              10,470              6,707
        Deferred income taxes                                             10,068               (834)                317
        Bad debt expense                                                   4,583               3,680              1,456
        Corporate restructuring, less cash payments of $184                1,467
        Tax benefit relating to employee stock options                     1,345               3,174                661
        Changes in operating assets and liabilities, net of
          changes resulting from acquisition:
            Receivables                                                 (35,083)            (50,166)           (48,149)
            Inventories                                                 (15,417)            (11,444)            (3,638)
            Prepaid expenses and other assets                                756               1,722            (3,104)
            Claims and rebates payable                                   107,660              57,968             41,055
            Accounts payable and accrued expenses                       (18,521)               4,504              8,410
                                                              ---------------------------------------------------------
Net cash provided by operating activities                                126,574              52,503             29,863
                                                              ---------------------------------------------------------

Cash flows from investing activities:
    Acquisitions, net of cash acquired                                 (460,137)                                  (940)
    Short-term investments                                                57,938             (3,550)           (54,388)
    Purchases of property and equipment                                 (23,853)            (13,017)            (9,480)
                                                              ---------------------------------------------------------
Net cash (used in) investing activities                                (426,052)            (16,567)           (64,808)
                                                              ---------------------------------------------------------

Cash flows from financing activities:
    Proceeds on long-term debt                                           360,000                   -                  -
    Proceeds from stock offering                                                                                 52,592
    Deferred financing fees                                              (4,062)
    Acquisition of treasury stock                                                            (1,739)            (5,250)
    Exercise of stock options                                              2,021               4,772              1,310
                                                              ---------------------------------------------------------
Net cash provided by financing activities                                357,959               3,033             48,652
                                                              ---------------------------------------------------------

Effect of foreign currency translation adjustment                           (47)                (25)                (2)
                                                              ---------------------------------------------------------

Net increase in cash and cash equivalents                                 58,434              38,944             13,705
Cash and cash equivalents at beginning of year                            64,155              25,211             11,506
                                                              =========================================================
Cash and cash equivalents at end of year                             $   122,589        $     64,155       $     25,211
                                                              =========================================================
Supplemental data:
Cash paid during the year for:
    Income taxes                                                    $     17,202        $     20,691       $     14,544
    Interest                                                        $     13,568      $          225    $            59

</TABLE>

SEE ACCOMPANYING NOTES TO CONSOLIDATED FINANCIAL STATEMENTS


<PAGE>


NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

- -------------------------------------------------------------------------------

1. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

     ORGANIZATION AND OPERATIONS.  Express Scripts,  Inc. (the "Company") is the
largest full-service  pharmacy benefit management ("PBM") company independent of
pharmaceutical manufacturer ownership and drug store ownership in North America.
The Company  provides  health care  management  and  administration  services on
behalf of thousands of clients that include  health  maintenance  organizations,
health  insurers,  third-party  administrators,  employers  and  union-sponsored
benefit  plans.  The Company's  fully-integrated  PBM services  include  network
claims processing,  mail-order pharmacy services,  benefit design  consultation,
drug utilization review, formulary management,  disease management,  medical and
drug data analysis services,  medical  information  management  services,  which
include provider  profiling and outcome  assessments  through its majority-owned
Practice  Patterns  Science,  Inc.  ("PPS")  subsidiary,  and informed  decision
counseling services through its Express Health LineSM division. The Company also
provides  non-PBM  services which include  infusion therapy services through its
wholly-owned  subsidiary IVTx, Inc. ("IVTx"),  distribution services through its
Specialty  Distribution  division,  and,  prior to September  1, 1998,  provided
managed vision care programs through its wholly-owned subsidiary Express Scripts
Vision Corporation ("Vision").

     In March 1992, the Company,  originally  incorporated  in Missouri in 1986,
was  reincorporated  in Delaware and issued an aggregate of 21,000,000 shares of
Class B Common Stock to Sanus Corp. Health Systems ("Sanus") in exchange for the
outstanding  shares of its  common  stock.  Sanus at that  time was an  indirect
subsidiary  of New York Life  Insurance  Company  ("NYL").  In April 1992,  as a
result  of  a   reorganization,   both  the  Company  and  Sanus  became  direct
subsidiaries of NYLIFE HealthCare Management,  Inc. ("NYLIFE").  Sanus has since
changed  its name to NYLCare  Health  Plans,  Inc.  ("NYLCare").  In April 1996,
NYLIFE converted 5,980,000 Class B shares to Class A Common Stock and sold those
shares  in a  public  offering.  NYLIFE  continues  to  own  all  the  remaining
outstanding Class B Common Stock of the Company (see Note 11).

     BASIS OF PRESENTATION.  The consolidated  financial  statements include the
accounts of the Company and all  wholly-owned and  majority-owned  subsidiaries.
All significant  intercompany  accounts and  transactions  have been eliminated.
Certain  amounts in prior  years  have been  reclassified  to conform  with 1998
classifications.  The  preparation  of  the  consolidated  financial  statements
conform to generally accepted accounting  principles,  and require management to
make estimates and  assumptions  that affect the reported  amounts of assets and
liabilities at the date of the financial  statements and the reported amounts of
revenues and expenses during the reporting  period.  Actual amounts could differ
from those estimates and assumptions.

     CASH AND CASH EQUIVALENTS.  Cash and cash equivalents  include cash on hand
and temporary investments in money market funds.

     SHORT-TERM INVESTMENTS. Short-term investments consisted of debt securities
with a maturity of less than one year that the Company had the  positive  intent
and ability to hold to maturity and are reported at amortized cost.

     INVENTORIES. Inventories consist of prescription drugs, vision supplies and
medical  supplies  that are stated at the lower of  first-in  first-out  cost or
market.

     PROPERTY AND  EQUIPMENT.  Property and  equipment is carried at cost and is
depreciated using the straight-line  method over estimated useful lives of seven
years for furniture,  five years for equipment and purchased  computer  software
and three years for personal computers.  Leasehold improvements are amortized on
a  straight-line  basis  over the term of the  lease or the  useful  life of the
asset,  if shorter.  Expenditures  for  repairs,  maintenance  and  renewals are
charged to income as incurred. Expenditures which improve an asset or extend its
estimated useful life are capitalized.  When properties are retired or otherwise
disposed of, the related cost and accumulated  depreciation are removed from the
accounts and any gain or loss is included in income.

     SOFTWARE DEVELOPMENT COSTS. Research and development  expenditures relating
to the  development  of software  to be  marketed to clients,  or to be used for
internal  purposes,  are charged to expense until  technological  feasibility is
established.  Thereafter, the remaining software production costs up to the date
of general  release to  customers,  or to the date placed into  production,  are
capitalized and included as Property and Equipment.  During 1998, 1997 and 1996,
$10,244,000,  $1,982,000  and  $1,898,000  in  software  development  costs were
capitalized,  respectively.  Capitalized  software development costs amounted to
$27,516,000  and  $5,269,000  at  December  31,  1998  and  1997,  respectively.
Amortization of the capitalized amounts commences on the date of general release
to  customers,  or  the  date  placed  into  production,  and is  computed  on a
product-by-product  basis  using the  straight-line  method  over the  remaining
estimated economic life of the product but not more than five years. Reductions,
if any, in the carrying  value of  capitalized  software costs to net realizable
value are also included in amortization  expense.  Amortization expense in 1998,
1997 and 1996 was $1,968,000, $622,000 and $136,000, respectively.

     GOODWILL.  Goodwill is amortized on a straight-line basis over periods from
15 to 30 years.  The  amount  reported  is net of  accumulated  amortization  of
$8,114,000 and $251,000 at December 31, 1998 and 1997, respectively. The Company
periodically  evaluates  the  carrying  value of goodwill  for  impairment.  The
evaluation of impairment is based on expected future  operating cash flows on an
undiscounted  basis for the  operations to which  goodwill  relates.  Impairment
losses, if any, would be determined based on the present value of the cash flows
using discount rates that reflect the inherent risk of the underlying  business.
In the opinion of management, no such impairment existed at December 31, 1998 or
1997.  Amortization  expense,  included in selling,  general and  administrative
expenses,  was $7,863,000,  $42,000 and $42,000 for the years ended December 31,
1998, 1997 and 1996, respectively.

     OTHER INTANGIBLE ASSETS. Other intangible assets (included in other assets)
consist of customer  contracts,  non-compete  agreements and deferred  financing
fees and are amortized on a straight-line basis over periods from 2 to 20 years.
Amortization expense for customer contracts and non-compete agreements, included
in selling,  general and  administrative  expenses,  and for deferred  financing
fees, included in interest expense,  was $4,320,000 and $609,000,  respectively,
for the year ended December 31, 1998.

     CONTRACTUAL  AGREEMENTS.  The Company has entered into corporate  alliances
with certain of its clients whereby shares of the Company's Class A Common Stock
were awarded as advance discounts to the clients. The Company accounts for these
agreements as follows:

     PRIOR TO DECEMBER 15, 1995 - For agreements  consummated  prior to December
15, 1995, the stock is valued  utilizing the quoted market value at the date the
agreement is consummated  if the number of shares to be issued is known.  If the
number  of  shares to be issued  is  contingent  upon the  occurrence  of future
events,  the stock is valued  utilizing  the quoted market value at the date the
contingency is satisfied and the number of shares is determinable.

     BETWEEN  DECEMBER 15, 1995 AND NOVEMBER 20, 1997 - For  agreements  entered
into between  these dates,  the Company  utilizes  the  provisions  of Financial
Accounting   Standards   Board   Statement  123   "Accounting   for  Stock-Based
Compensations"  ("FAS 123") which requires that all stock issued to nonemployees
be accounted  for based on the fair value of the  consideration  received or the
fair value of the equity  instruments  issued  instead  of the  intrinsic  value
method  utilized for stock issued or to be issued under  alliances  entered into
prior to  December  15,  1995.  The Company has adopted FAS 123 as it relates to
stock issued or to be issued under the Premier and Manulife  alliances  based on
fair value at the date the agreement was consummated.

     SUBSEQUENT  TO NOVEMBER 20, 1997 - In November  1997,  the Emerging  Issues
Task Force reached a consensus that the value of equity  instruments  issued for
consideration other than employee services should be initially determined on the
date on which a "firm  commitment" for performance  first exists by the provider
of goods or services.  Firm  commitment  is defined as a commitment  pursuant to
which  performance  by a provider of goods or  services  is probable  because of
sufficiently  large  disincentives  for  nonperformance.  The consensus  must be
applied for all new  arrangements  and  modifications  of existing  arrangements
entered into from November 20, 1997.  The consensus only addresses the date upon
which fair value is  determined  and does not change the  accounting  based upon
fair value as prescribed by FAS 123. No such arrangements have been entered into
by the Company subsequent to November 20, 1997.

     Shares  issued  on the  effective  date of the  contractual  agreement  are
considered  outstanding  and  included in basic and diluted  earnings  per share
computations  when issued.  Shares  issuable  upon the  satisfaction  of certain
conditions  are  considered  outstanding  and  included  in basic  and  dilutive
earnings per share computation when all necessary conditions have been satisfied
by the end of the period. If all necessary conditions have not been satisfied by
the end of the period,  the number of shares  included in the dilutive  earnings
per share  computation  is based on the number of shares,  if any, that would be
issuable  if the end of the  reporting  period  were the end of the  contingency
period and if the  result  would be  dilutive.  The value of the shares of stock
awarded as advance  discounts  is  recorded as a deferred  cost and  included in
other  assets.  The  deferred  cost  is  recognized  in  selling,   general  and
administrative expenses over the period of the contract.

     IMPAIRMENT OF LONG LIVED ASSETS.  The Company  evaluates whether events and
circumstances have occurred that indicate the remaining estimated useful life of
long lived assets may warrant revision or that the remaining balance of an asset
may not be recoverable.  The measurement of possible  impairment is based on the
ability to recover the balance of assets from  expected  future  operating  cash
flows on an undiscounted  basis.  Impairment losses, if any, would be determined
based on the present value of the cash flows using  discount  rates that reflect
the inherent risk of the underlying business.  In the opinion of management,  no
such impairment existed as of December 31, 1998 or 1997.

     DERIVATIVE FINANCIAL INSTRUMENTS.  The Company has entered into an interest
rate swap  agreement  in order to manage  exposure  to interest  rate risk.  The
Company  does not hold or issue  derivative  financial  instruments  for trading
purposes.  The  interest  rate swap is  designated  as a hedge of the  Company's
variable  interest  rate  payments.  Amounts  received  or paid are  accrued  as
interest receivable or payable and as interest income or expense. The fair value
of  interest  rate swap  agreements  is based on market  prices.  The fair value
represents the estimated  amount the Company would  receive/pay to terminate the
agreements taking into consideration current interest rates.

     In June 1998, the Financial  Accounting Standards Board ("the FASB") issued
Statement of Financial  Accounting Standards No. 133, "Accounting for Derivative
Instruments  and Hedging  Activities"  ("FAS 133").  The Statement  requires all
derivatives  be recognized as either assets or  liabilities  in the statement of
financial position and measure those instruments at fair value. In addition, the
Statement specifies the accounting for changes in the fair value of a derivative
based on the intended use of the derivative and the resulting  designation.  FAS
133 is effective for all fiscal  quarters of fiscal years  beginning  after June
15, 1999 and will be applicable  to the  Company's  first quarter of fiscal year
2000. The Company's  present interest rate swap (see Note 6) would be considered
a cash flow hedge.  Accordingly,  the change in the fair value of the swap would
be reported on the balance  sheet as an asset or  liability.  The  corresponding
unrealized gain or loss  representing the effective portion of the hedge will be
initially recognized in stockholders' equity and other comprehensive income, and
subsequently any changes in unrealized gain or loss from the initial measurement
date will be recognized in earnings  concurrent with the interest expense on the
Company's  underlying  variable rate debt. If the Company had adopted FAS 133 as
of December 31, 1998, the Company would record the unrealized loss of $7,209,000
as a liability and  reduction in  stockholder's  equity and other  comprehensive
income.

     FAIR VALUE OF FINANCIAL  INSTRUMENTS.  The carrying  value of cash and cash
equivalents,  short-term  investments,  accounts receivable and accounts payable
approximated fair values due to the short-term  maturities of these instruments.
The fair value,  which  approximates  the carrying  value, of the Company's term
loan  facility was  estimated  using either  quoted market prices or the current
rates offered to the Company for debt with similar  maturity.  The fair value of
the swap ($7,209,000  liability at December 31, 1998) was based on quoted market
price,  which  reflects the present value of the  difference  between  estimated
future fixed rate payments and future variable rate receipts.

     REVENUE   RECOGNITION.    Revenues   from   dispensing   prescription   and
non-prescription medical products from the Company's mail service pharmacies are
recorded upon shipment.  Revenue from sales of prescription  drugs by pharmacies
in the Company's  nationwide network and pharmacy claims processing revenues are
recognized   when  the  claims  are  processed.   When  the  Company   dispenses
pharmaceuticals  to members of health  benefit plans  sponsored by the Company's
clients or has an independent contractual obligation to pay its network pharmacy
providers  for  benefits  provided to members of its clients'  pharmacy  benefit
plans,  the Company  includes  payments from plan sponsors for these benefits as
net revenue and ingredient costs or payments to these pharmacy providers in cost
of revenues.  If the Company is only  administering  the plan sponsors'  network
pharmacy contracts, or where the Company dispenses  pharmaceuticals  supplied by
one of the Company's  clients,  the Company records only the  administrative  or
dispensing  fees derived from the Company's  contracts with the plan sponsors as
net revenue.

     COST OF REVENUES.  Cost of revenues includes product costs, pharmacy claims
payments and other direct costs  associated  with dispensing  prescriptions  and
non-prescription  medical products and claims processing  operations,  offset by
fees received from pharmaceutical manufacturers in connection with the Company's
drug purchasing and formulary management programs.

     INCOME TAXES.  Deferred tax assets and liabilities are recognized  based on
temporary  differences between financial statement basis and tax basis of assets
and liabilities using presently enacted tax rates.

     EARNINGS PER SHARE. Basic earnings per share is computed using the weighted
average number of common shares outstanding during the period.  Diluted earnings
per share is computed in the same  manner as basic  earnings  per share but adds
the number of additional  common shares that would have been outstanding for the
period  if the  dilutive  potential  common  shares  had been  issued.  The only
difference  between the number of weighted  average shares used in the basic and
diluted calculation for all years is stock options and stock warrants granted by
the Company using the "treasury stock" method, amounting to 593,000, 409,000 and
540,000 in 1998, 1997 and 1996, respectively.

     FOREIGN CURRENCY TRANSLATION.  The financial statements of ESI Canada, Inc.
are translated  into U.S.  Dollars using the exchange rate at each balance sheet
date for assets and  liabilities and a weighted  average  exchange rate for each
period for revenues, expenses, gains and losses. The functional currency for ESI
Canada,  Inc. is the local  currency and  translation  adjustments  are recorded
within the other comprehensive income component of stockholders' equity.

     EMPLOYEE STOCK-BASED COMPENSATION.  The Company accounts for employee stock
options  in  accordance  with  Accounting  Principles  Board No. 25 ("APB  25"),
"Accounting  for Stock Issued to Employees."  Under APB 25, the Company  applies
the intrinsic  value method of  accounting  and,  therefore,  does not recognize
compensation expense for options granted,  because options are only granted at a
price equal to market value at the time of grant.  During  1996,  FAS 123 became
effective for the Company.  FAS 123 prescribes the  recognition of  compensation
expense  based on the fair  value  of  options  determined  on the  grant  date.
However,  FAS 123 grants an exception that allows companies  currently  applying
APB 25 to continue  using that method.  The Company has,  therefore,  elected to
continue  applying the intrinsic  value method under APB 25. For companies  that
choose to continue applying the intrinsic value method, FAS 123 mandates certain
pro forma  disclosures  as if the fair value method had been  utilized (see Note
12).

     COMPREHENSIVE  INCOME.  During  1998,  Statement  of  Financial  Accounting
Standards  No.  130  ("FAS  130"),  "Reporting   Comprehensive  Income,"  became
effective for the Company.  FAS 130 requires  noncash  changes in  stockholders'
equity be combined  with net income and  reported in a new  financial  statement
category  entitled  "comprehensive  income."  Other  than net  income,  the only
component of  comprehensive  income for the Company is the change in the foreign
currency translation adjustment.  The Company has displayed comprehensive income
within the Statement of Changes in Stockholders' Equity.

     SEGMENT  REPORTING.  In June 1997,  the FASB issued  Statement of Financial
Accounting  Standards No. 131,  "Disclosures about Segments of an Enterprise and
Related  Information"  ("FAS  131").  FAS 131 requires  that the Company  report
certain information,  if specific requirements are met, about operating segments
of the  Company  including  information  about  services,  geographic  areas  of
operation  and  major  customers.  The  information  is to be  derived  from the
management  approach which designates the internal  organization that is used by
management  for making  operating  decisions  and assessing  performance  as the
source of the Company's reportable segments.  Adoption of FAS 131 did not affect
the Company's results of operations or its financial position but did affect the
disclosure of segment information (see Note 13).

2. ACQUISITION

     On April 1, 1998 the Company acquired all of the outstanding  capital stock
of Value Health, Inc. and Managed Prescriptions Network, Inc. (collectively, the
"Acquired Entities") from Columbia/HCA  Healthcare Corporation  ("Columbia") for
approximately  $460  million  in cash  (which  includes  transactions  costs and
executive  management  severance  costs of  approximately  $6.7 million and $8.3
million, respectively), approximately $360 million of which was obtained through
a  five-year  bank  credit  facility  (see  Note 6) and the  remainder  from the
Company's  cash balances and short term  investments.  At closing,  the Acquired
Entities  owned  various  subsidiaries  that  now or  formerly  conducted  a PBM
business, commonly known as "ValueRx".

     The  acquisition  has been  accounted  for  using  the  purchase  method of
accounting  and the results of  operations  of the Acquired  Entities  have been
included in the consolidated financial statements and PBM segment since April 1,
1998. The purchase price has been preliminarily allocated based on the estimated
fair values of net assets acquired at the date of the acquisition. The excess of
purchase  price over tangible net assets  acquired was  originally  allocated to
other  intangible  assets  consisting  of  customer  contracts  and  non-compete
agreements  in the amount of  $57,653,000  which are being  amortized  using the
straight-line  method over the  estimated  useful lives of 2 to 20 years and are
included in other assets,  and goodwill in the amount of  $289,863,000  which is
being amortized using the straight-line method over the estimated useful life of
30 years. In conjunction with the acquisition,  the Acquired  Entities and their
subsidiaries retained the following liabilities:

<TABLE>
<CAPTION>

(IN THOUSANDS)
<S>                                         <C>                 
- ----------------------------------------------------------------
Fair value of assets acquired               $            656,488
Cash paid for the capital stock                        (460,137)
                                          =======================
          Liabilities retained              $            196,351
                                          =======================
</TABLE>

         The following unaudited pro forma information presents a summary of
combined results of operations of the Company and the Acquired Entities as if
the acquisition had occurred at the beginning of the period presented, along
with certain pro forma adjustments to give effect to amortization of goodwill,
other intangible assets, interest expense on acquisition debt and other
adjustments. The pro forma financial information is not necessarily indicative
of the results of operations as they would have been had the transaction been
effected on the assumed dates. Included in the pro forma information are
integration costs incurred by the Company that are being reported within
selling, general and administrative expenses in the statement of operations.

<TABLE>
<CAPTION>

                                                 YEAR ENDED DECEMBER 31,
(IN THOUSANDS, EXCEPT PER SHARE DATA)         1998                    1997
<S>                                       <C>                     <C>         
- -------------------------------------------------------------------------------
Net revenues                              $  3,234,800            $  2,877,906
Net income                                      42,696                  33,687
Basic earnings per share                          1.29                    1.03
Diluted earnings per share                        1.27                    1.02

</TABLE>

3. CONTRACTUAL AGREEMENTS

     On  December  31,  1995,  the  Company  entered  into a ten-year  corporate
alliance with Premier Purchasing Partners,  L.P. (formerly,  American Healthcare
Systems Purchasing Partners, L.P., the "Partnership"),  an affiliate of Premier,
Inc.  ("Premier").  Premier is an alliance of health care systems resulting from
the merger in 1995 of American Healthcare  Systems,  Premier Health Alliance and
SunHealth Alliance. Under the terms of the transaction, the Company is Premier's
preferred   vendor  of  pharmacy  benefit   management   services  to  Premier's
shareholder  systems and their managed care  affiliates and will issue shares of
its Class A Common Stock as an  administrative  fee to the Partnership  based on
the  attainment  of  certain  benchmarks,  principally  related to the number of
members receiving the Company's pharmacy benefit  management  services under the
arrangement,  and to the  achievement  of certain joint  purchasing  goals.  The
Company may be required to issue up to 4,500,000  shares to the Partnership over
a period up to the first five years of the agreement if the Partnership  exceeds
all benchmarks.  Except for certain  exemptions from registration under the 1933
Act, any shares issued to the Partnership  cannot be traded until they have been
registered under the 1933 Act and any applicable state securities laws.

     In accordance  with the terms of the agreement,  the Company issued 454,546
shares of Class A Stock to  Premier in May,  1996.  The  shares  were  valued at
$11,250,000  and  are  being  amortized  over  the  then  remaining  term of the
agreement.   Amortization  expense  in  1998,  1997  and  1996  was  $1,164,000,
$1,164,000 and $776,000,  respectively. No additional shares have been earned by
Premier through December 31, 1998.

     Effective January 1, 1996, the Company executed a multi-year  contract with
The Manufacturers  Life Insurance Company  ("Manulife"),  to introduce  pharmacy
benefit  management  services  in Canada.  Manulife's  Group  Benefits  Division
continues to work with ESI Canada to provide these services.  Under the terms of
the  agreement,  the Company is the exclusive  third-party  provider of pharmacy
benefit  management  services to Manulife's  Canadian clients.  The Company also
will issue shares of its Class A Common Stock as an advance discount to Manulife
based upon achievement of certain volumes of Manulife  pharmacy claims processed
by the  Company.  No shares  will be issued  until  after the fourth year of the
agreement  based on  volumes  reached in years two  through  four.  The  Company
anticipates  issuing no more than 474,000 shares to Manulife over a period up to
the  first  six years of the  agreement.  Except  for  certain  exemptions  from
registration  under the 1933 Act, any shares issued to Manulife cannot be traded
until  they have been  registered  under the 1933 Act and any  applicable  state
securities  laws. In accordance  with the terms of the  agreement,  no stock has
been issued since inception.

     If Manulife has not exercised an early termination option at the end of the
sixth or tenth year of the  agreement,  the Company  will issue at each of those
times a ten-year  warrant as an advance discount to purchase up to approximately
237,000  additional  shares of the Company's Class A Common Stock exercisable at
85% of the market  price at those times.  The actual  number of shares for which
such warrant is to be issued is based on the volume of Manulife  pharmacy claims
processed by the Company in year six and year ten, respectively.

     Pursuant to an agreement with Coventry  Corporation,  an operator of health
maintenance  organizations  located principally in Pennsylvania and Missouri, on
January 3, 1995,  the Company issued 50,000 shares of Class A Common Stock as an
advance discount to Coventry in a private placement. These shares were valued at
$13.69 per share,  the  split-adjusted  per share market value of the  Company's
Class A Common Stock on November 22, 1994,  which was the date the agreement was
consummated and the obligation of the parties became unconditional.  No revision
of the consideration for the transaction  occurred between November 22, 1994 and
January 3, 1995.  The shares  issued to  Coventry  were being  amortized  over a
six-year period.  However,  due to Coventry extending the agreement for only two
years, as discussed below,  instead of three years, the estimated useful life of
the shares  issued has been  reduced to five  years.  Amortization  expense  was
$171,000,  $114,000 and $114,000 for each of the years ended  December 31, 1998,
1997 and 1996,  respectively.  Except for certain  exemptions from  registration
under the Securities Act of 1933 ("the 1993 Act"), these shares cannot be traded
until  they have been  registered  under the 1933 Act and any  applicable  state
securities laws.

     Effective  January 1, 1998,  Coventry  renewed the agreement for a two-year
term through  December 31, 1999. As part of the  agreement,  the Company  issued
warrants as an advance  discount to purchase an additional  50,000 shares of the
Company's  Class A Common Stock,  exercisable  at 90% of the market value at the
time of renewal.  During 1998, the Company  expensed the advance  discount which
represented 10% of the market value.

     On October 13, 1992, the Company entered into a five-year  arrangement with
FHP,  Inc.  ("FHP")  pursuant  to which the Company  agreed to provide  pharmacy
benefit  services  to  FHP  and  its  members.  FHP  is an  operator  of  health
maintenance organizations, principally in the western United States. In February
1997, PacifiCare Health Systems, Inc.  ("PacifiCare")  completed the acquisition
of FHP. As a result of the merger, PacifiCare informed the Company that it would
not enter into a long-term  extension of the  agreement and reached an agreement
with the Company to  phase-out  membership  starting in July 1997 and  continued
through March 1998.

     In accordance with the agreement,  the Company commenced providing pharmacy
benefit  services to FHP and its members on January 4, 1993. On the commencement
date and pursuant to the  agreement,  the Company  issued  400,000 shares of its
Class A Common Stock as advance discounts to FHP in a private  placement.  These
shares were valued at $4.13 per share, the split-adjusted per share market value
of the  Company's  Class A shares on October  13,  1992,  which was the date the
agreement  was   consummated   and  the   obligations   of  the  parties  became
unconditional.  No revision of the  consideration  for the transaction  occurred
between  October 13, 1992 and January 4, 1993.  The cost of the shares issued to
FHP was  amortized  over a  five-year  period  ending in 1997.  No  amortization
expense was  recorded  in 1998.  Amortization  expense was  $990,000 in 1997 and
$165,000 in 1996.

4. RELATED PARTY TRANSACTIONS

     The Company had agreements to provide claims  processing  services and mail
pharmacy  prescription  services  for  NYLCare,  in return for which it receives
processing  fees  and  reimbursement  for the  contracted  cost  of the  claims.
Effective  July 15,  1998,  NYL  consummated  the sale of  NYLCare to Aetna U.S.
Healthcare,  Inc., an unrelated party. Therefore, related party amounts for 1998
represent only the period in which NYL owned NYLCare. Transactions subsequent to
July 15, 1998 have been  included in unrelated  parties.  Cost of revenues  from
related parties were  $127,255,000,  $176,761,000 and $122,157,000 in 1998, 1997
and 1996, respectively.

The amount receivable from or (due to) related parties comprised the following:

<TABLE>
<CAPTION>

                                                 DECEMBER 31,
(IN THOUSANDS)                                       1997
<S>                                                     <C>     
- ----------------------------------------------------------------
Receivable from NYLCare                                 $ 23,709
Due to NYLCare                                           (7,479)
                                          =======================
Total related party receivable                          $ 16,230
                                          =======================
</TABLE>

         Prior to July 15, 1998, the Company was the exclusive provider of
pharmacy benefit management services to NYLCare's managed health care
subsidiaries, subject to certain exceptions. The Company's agreement with
NYLCare provided that fees from drug manufacturers whose products are used in
the Company's formularies related to NYLCare subsidiaries was allocated 100% to
the Company up to $400,000 and 75% to NYLCare and 25% to the Company thereafter.
The Company was also the non-exclusive provider of pharmacy benefit management
services to New York Life and Health Insurance Company ("NYLHIC"), a subsidiary
of NYLCare. In 1996 fees from drug manufacturers with respect to this business
were allocated 100% to the Company. Effective January 1, 1997, the Company
shared such fees with NYLHIC on a fixed per script amount which approximates 40%
of the total of such fees.

         Such fees allocated to NYLCare and NYLHIC were $7,257,000, $11,690,000
and $7,636,000 in 1998, 1997 and 1996, respectively, and $2,307,000 in 1998,
$5,803,000 in 1997 and $3,064,000 in 1996 were allocated to the Company and have
been classified in the accompanying consolidated statement of operations as a
reduction of cost of revenues.

         As discussed in Note 3, the Company has entered into a ten year
corporate alliance with Premier. Richard Norling is the Chief Operating Officer
of Premier and a member of the Company's Board of Directors. No consideration,
monetary or otherwise, has been exchanged between the Company and Premier
between the period September 1997 and December 1998 (the period during which
Premier and the Company are related parties). The Company may be required to
issue additional shares of its Class A Common Stock to Premier as discussed in
Note 3.

         Premier is required to promote the Company as the preferred PBM
provider to health care entities, plans and facilities which participate in
Premier's purchasing programs. However, all contractual arrangements to provide
services are made directly between the Company and these entities, at varying
terms and independent of any Premier involvement. Therefore, the associated
revenues earned and expenses incurred by the Company are not deemed to be
related party transactions. During 1998, the net revenues that the Company
derived from services provided to the health care entities participating in
Premier's purchasing programs was $78,539,000.

5. PROPERTY AND EQUIPMENT

Property and equipment, at cost, consists of the following:

<TABLE>
<CAPTION>

                                                DECEMBER 31,
(IN THOUSANDS)                           1998                    1997
<S>                                  <C>                  <C>            
- -------------------------------------------------------------------------
Land                                 $      2,051         $             -
Building                                    3,076
Furniture                                   8,336                   4,362
Equipment                                  52,758                  28,924
Computer software                          37,412                  12,011
Leasehold improvements                      8,275                   3,934
                                    -------------------------------------
                                          111,908                  49,231
Less accumulated depreciation and
    amortization                           34,409                  22,410
                                    -------------------------------------
                                       $   77,499              $   26,821
                                    =====================================
</TABLE>

6. FINANCING

     On April 1, 1998, the Company  executed a $440 million credit facility with
a bank syndicate led by Bankers Trust Company, consisting of a $360 million term
loan facility and an $80 million  revolving loan facility.  The credit  facility
expires  on  April  15,  2003  and  is  guaranteed  by  the  Company's  domestic
subsidiaries  other than Practice  Patterns  Science,  Inc.  ("PPS"),  and Great
Plains Reinsurance  Company ("Great Plains") and secured by pledges of 100% (or,
in the case of foreign subsidiaries,  65%) of the capital stock of the Company's
subsidiaries  other  than PPS and  Great  Plains.  The  provisions  of this loan
require quarterly  interest payments and,  beginning in April 1999,  semi-annual
principal  payments.  The  interest  rate is  based on a  spread  ("Credit  Rate
Spread") over several  London  Interbank  Offered  Rates  ("LIBOR") or base rate
options,  depending upon the Company's ratio of earnings before interest, taxes,
depreciation and amortization to debt ("Leverage  Ratio"). At December 31, 1998,
the interest rate was 6.0625%,  representing  a credit rate spread of 0.75% over
the three month LIBOR rate. The credit  facility  contains  covenants that limit
the  indebtedness  the  Company  may  incur and the  amount  of  annual  capital
expenditures.  The covenants also establish a minimum interest coverage ratio, a
maximum  leverage ratio,  and a minimum  consolidated net worth. At December 31,
1998, the Company was in compliance with all covenants. In addition, the Company
is required to pay an annual fee  depending  on the leverage  ratio,  payable in
quarterly  installments,  on the  unused  portion  of the  revolving  loan.  The
commitment  fee was 22.5  basis  points at  December  31,  1998.  There  were no
borrowings at December 31, 1998 under the revolving loan facility.  The carrying
amount of the Company's term loan facility approximates fair value.

     In conjunction with the credit facility and as part of the Company's policy
to manage  interest  rate risk,  the Company  entered into an interest rate swap
agreement ("swap") with The First National Bank of Chicago, a subsidiary of Bank
One Corporation, on April 3, 1998. At December 31, 1998, the swap had a notional
principal  amount of $360  million.  Under the  terms of the swap,  the  Company
agrees to receive a  floating  rate of  interest  on the amount of the term loan
facility  based on a three month  LIBOR rate in exchange  for payment of a fixed
rate of interest of 5.88% per annum.  The notional  principal amount of the swap
amortizes in equal amounts with the principal balance of the term loan facility.
As a result,  the Company has, in effect,  converted its variable rate term debt
to fixed  rate  debt at 5.88% per  annum  for the  entire  term of the term loan
facility, plus the Credit Rate Spread.

     The following  represents  the schedule of current  maturities for the term
loan facility (amounts in thousands):

<TABLE>
<CAPTION>

 Year Ended December 31,
<S>        <C>                              <C>                
- ---------------------------------------------------------------
           1999                             $            54,000
           2000                                          72,000
           2001                                          90,000
           2002                                          96,000
           2003                                          48,000
                                         =======================
                                             $          360,000
                                         =======================
</TABLE>

     Prior to April 1, 1998, the Company maintained a $25,000,000 unsecured line
of credit with the  Mercantile  Bank National  Association  which was terminated
upon the consummation of the Bankers' Trust credit facility.  Additionally,  the
Company  allowed another line of credit in the amount of $25 million to lapse on
October 31, 1997. Terms of the agreements were as follows:  interest was charged
on the  principal  amount  outstanding  at a rate equal to any of the  following
options  which the Company,  at its option shall  select:  (i) the bank's "prime
rate", (ii) a floating rate equal to the Bank's cost of funds rate plus 50 basis
points, or (iii) a fixed rate for periods of 30, 60, 90 or 180 days equal to the
LIBOR rate plus 50 basis points. Fees under the agreements on any unused portion
were charged at ten  hundredths  of one percent per year.  At December 31, 1997,
the Company  had no  outstanding  borrowings  under this  agreement,  nor did it
borrow any amounts under these agreements during 1997.


7. CORPORATE RESTRUCTURING

     During  1998,  the  Company  recorded  a  pre-tax  restructuring  charge of
$1,651,000  ($1,002,000  after taxes or $0.03 per basic  earnings  per share and
$0.03 per dilutive  earnings per share)  associated with the Company closing the
non-PBM service  operations of its wholly-owned  subsidiary,  PhyNet,  Inc., and
transferring  certain  functions of its Express  Scripts  Vision  Corporation to
another vision care provider.

<TABLE>
<CAPTION>

                                                                                                 BALANCE AT
                                                   1998                    UTILIZED              DECEMBER 31,
(AMOUNTS IN THOUSANDS)                            CHARGE            CASH             NONCASH          1998
<S>                                               <C>           <C>                  <C>               <C>   
- -------------------------------------------------------------------------------------------------------------
Write-down of long-lived assets                   $1,235        $       -            $  704            $  531
Employee transition costs for 61 employees           416              184                 -               232
                                            ============= ================ ================= =================
                                                  $1,651           $  184            $  704            $  763
                                            ============= ================ ================= =================
</TABLE>


     The  restructuring  charge includes tangible assets to be disposed of being
written down to their net realizable value, less cost of disposal.  Considerable
management  judgment is necessary to estimate  fair value,  accordingly,  actual
results could vary from such estimates.  The Company anticipates  completing the
remainder of the restructuring actions by the end of the third quarter of 1999.

<PAGE>


8. INCOME TAXES

         The income tax provision consists of the following:

<TABLE>
<CAPTION>


                                                  YEAR ENDED DECEMBER 31,
(IN THOUSANDS)                                 1998              1997              1996
<S>                                           <C>             <C>               <C>     
- -----------------------------------------------------------------------------------------
Current provision:
    Federal                                   $ 20,171        $ 19,048          $ 13,945
    State                                        3,049           2,779             2,480
    Foreign                                        278             284               190
                                             --------------------------------------------
        Total current provision                 23,498          22,111            16,615
                                             --------------------------------------------
Deferred provision:
    Federal                                      8,694           (714)               267
    State                                        1,374           (120)                50
                                             --------------------------------------------
        Total deferred provision                10,068           (834)               317
                                             --------------------------------------------
Total current and deferred provision          $ 33,566        $ 21,277          $ 16,932
                                             ============================================
</TABLE>

     A reconciliation of the statutory federal income tax rate and the effective
tax rate  follows  (The effect of foreign  taxes on the  effective  tax rate for
1998, 1997 and 1996 is immaterial):

<TABLE>
<CAPTION>


                                                              YEAR ENDED DECEMBER 31,
                                                   1998           1997                1996
<S>                                                <C>             <C>                <C>  
- -------------------------------------------------------------------------------------------
Statutory federal income tax rate                  35.0%           35.0%              35.0%
State taxes net of federal benefit                  3.8             3.8                4.3
Non-deductible amortization of goodwill and
    customer contracts                              4.9
Other, net                                          0.3             0.1                 -
                                                  -----------------------------------------
Effective tax rate                                 44.0%           38.9%              39.3%
                                                  ==========================================
</TABLE>

     The  deferred  tax assets and  deferred  tax  liabilities  recorded  in the
consolidated balance sheet are as follows:

<TABLE>
<CAPTION>

                                                                  DECEMBER 31,
(IN THOUSANDS)                                             1998                    1997
<S>                                                             <C>                     <C>     
- ------------------------------------------------------------------------------------------------
Deferred tax assets:
   Allowance for bad debts                                      $  8,013                $  1,578
   Inventory costing capitalization and reserves                     684                     675
   Accrued expenses                                               34,170                     512
   Depreciation and property differences                           6,808
   Non-compete agreements                                            933
   Other                                                              17                      79
                                                  ----------------------------------------------
       Gross deferred tax assets                                  50,625                   2,844
Deferred tax liabilities:
   Depreciation and property differences                                                 (1,166)
   Other                                                           (462)                    (91)
                                                  ----------------------------------------------
       Gross deferred tax liabilities                              (462)                 (1,257)
                                                  ----------------------------------------------

Net deferred tax assets                                         $ 50,163                $  1,587
                                                  ==============================================

</TABLE>

     The  Company  believes  it is probable  that the net  deferred  tax assets,
reflected  above,  will be  realized in future tax  returns  primarily  from the
generation of future taxable income.

9. COMMITMENTS AND CONTINGENCIES

     The Company has entered into  noncancellable  agreements  to lease  certain
office  and  distribution  facilities  with  remaining  terms from one to eleven
years.  Rental expense under the office and  distribution  facilities  leases in
1998, 1997 and 1996 was $3,876,000, $2,272,000 and $2,099,000, respectively. The
future minimum lease payments due under  noncancellable  operating  leases is as
follows:

<TABLE>
<CAPTION>

            Year Ended December 31,
<S>                   <C>                          <C>              
- --------------------------------------------------------------------

                      1999                         $       5,555,000
                      2000                                 5,960,000
                      2001                                 5,873,000
                      2002                                 5,758,000
                      2003                                 5,667,000
                   Thereafter                             28,648,000
                                              =======================
                                                    $     57,462,000
                                              =======================
</TABLE>

     For the year ended December 31, 1998,  approximately 56.2% of the Company's
pharmaceutical purchases were through one wholesaler. The Company believes other
alternative  sources are readily available and that no other concentration risks
exist at December 31, 1998.

     In the ordinary course of business  (which includes the business  conducted
by ValueRx prior to the Company's  acquisition on April 1, 1998),  various legal
proceedings,  investigations  or claims  pending have arisen against the Company
and its  subsidiaries  (ValueRx  continues to be a party to several  proceedings
that  arose  prior to April 1,  1998).  The  effect of these  actions  on future
financial results is not subject to reasonable  estimation because  considerable
uncertainty  exists  about  the  outcomes.   Nevertheless,  in  the  opinion  of
management,   the  ultimate  liabilities   resulting  from  any  such  lawsuits,
investigations or claims now pending will not materially affect the consolidated
financial position, results of operations, or cash flows of the Company.

10. EMPLOYEE BENEFIT PLANS

     RETIREMENT SAVINGS PLAN. The Company offers all of its full-time  employees
a retirement  savings plan under  Section  401(k) of the Internal  Revenue Code.
Employees may elect to enter a written salary  deferral  agreement under which a
maximum of 10% of their salary  (effective  January 1, 1999 maximum  deferral is
12%),  subject to aggregate limits required under the Internal Revenue Code, may
be  contributed  to the  plan.  The  Company  matches  the  first  $2,000 of the
employee's contribution for the year. For the year ended December 1998, 1997 and
1996, the Company made contributions of approximately  $1,751,000,  $909,000 and
$639,000, respectively.

     EMPLOYEE  STOCK PURCHASE  PLAN. In December,  1998, the Company's  Board of
Directors  approved an employee stock purchase  plan,  effective  March 1, 1999,
that  qualifies  under Section 423 of the Internal  Revenue Code and permits all
employees,  excluding certain management level employees,  to purchase shares of
the  Company's  Class A  Common  Stock.  Participating  employees  may  elect to
contribute up to 10% of their salary to purchase common stock at the end of each
six month  participation  period at a  purchase  price  equal to 85% of the fair
market value of the common stock at the end of the participation period. Class A
Common Stock reserved for future  employee  purchases under the plan was 250,000
at December 31, 1998.

     DEFERRED COMPENSATION PLAN. In December,  1998, the Compensation  Committee
of the Board of Directors  approved a non-qualified  deferred  compensation plan
(the "Executive Deferred  Compensation  Plan"),  effective January 1, 1999, that
provides  benefits payable to eligible key employees at retirement,  termination
or death.  Benefit  payments are funded by a combination of  contributions  from
participants  and the  Company.  Participants  become  fully  vested in  Company
contributions on the third anniversary of the end of the plan year for which the
contribution  is  credited  to their  account.  For  1999,  the  annual  Company
contribution   will  be  equal  to  6%  of  each   participant's   total  annual
compensation,  with 25% being invested in the Company's Class A common stock and
the remaining being allocated to a variety of investment  options.  As a result,
of the implementation,  the Company accrued as compensation  expense $797,000 in
1998 as a past service  contribution  which is equal to 8% of each participant's
total annual cash compensation for the period of the participant's  past service
with the Company in a senior executive capacity.

11. COMMON STOCK

     The  holders  of Class A Common  Stock  have  one vote per  share,  and the
holders of Class B Common  Stock  have ten votes per  share.  NYLIFE is the sole
holder of Class B Common  Stock.  Class B Common  Stock  converts  into  Class A
Common Stock on a  share-for-share  basis upon transfer  (other than to New York
Life or its  affiliates) and is convertible at any time at the discretion of the
holder.  At December  31,  1998,  NYLIFE and the holders of Class A Common Stock
have control over approximately 89.0% and 11.0%,  respectively,  of the combined
voting power of all classes of Common Stock.

     In April 1996, NYLIFE converted 5,980,000 shares of Class B Common Stock to
Class A Common  Stock  and sold the  Class A shares  in a public  offering.  The
Company did not receive any proceeds from the sale of these shares.  The Company
sold an  additional  2,300,000  Class A shares in the same  stock  offering  and
received  net  proceeds of  $52,592,000  after  deducting  expenses  incurred in
connection with the offering.

     In October 1998,  the Company  announced a  two-for-one  stock split of its
Class A and Class B common stock for stockholders of record on October 20, 1998,
effective  October 30, 1998. The split was effected in the form of a dividend by
issuance of one additional share of Class A common stock for each share of Class
A common stock  outstanding and one additional share of Class B common stock for
each share of Class B common stock  outstanding.  The earnings per share and the
weighted average number of shares outstanding for basic and diluted earnings per
share have been adjusted for the stock split except on the Consolidated  Balance
Sheet and the Consolidated Statement of Changes in Stockholder's Equity.

     As of December 31,  1998,  the Company had  repurchased  a total of 475,000
shares  of its  Class A Common  Stock  under the  open-market  stock  repurchase
program  announced by the Company on October 25, 1996,  although no  repurchases
occurred during 1998. The Company's  Board of Directors  approved the repurchase
of up to 1,700,000  shares,  and placed no limit on the duration of the program.
Future  purchases,  if any,  will be in such  amounts  and at such  times as the
Company deems appropriate based upon prevailing market and business  conditions,
subject to certain restrictions in the credit agreement described above.

     As of December 31, 1998,  5,807,000  shares of the Company's Class A Common
Stock have been  reserved for issuance to  organizations  with which the Company
has signed contractual agreements (see Note 3).

12. STOCK-BASED COMPENSATION PLANS

     At December 31, 1998, the Company has three fixed stock-based  compensation
plans, which are described below.

     In April 1992, the Company  adopted a stock option plan which it amended in
1995,  which provides for the grant of nonqualified  stock options and incentive
stock  options to officers  and key  employees  of the  Company  selected by the
Compensation  Committee  of the Board of  Directors.  Initially,  a  maximum  of
1,400,000  shares of Class A Common Stock could be issued  under the plan.  That
amount increases  annually each January 1, from January 1, 1993 to and including
January 1, 1999 by  140,000,  to a maximum of  2,380,000  shares.  By  unanimous
written  consent dated June 6, 1994, the Board of Directors  adopted the Express
Scripts,  Inc.  1994 Stock Option Plan,  also amended in 1995,  1997 and 1998. A
total  of  1,920,000  shares  of the  Company's  Class A Common  Stock  has been
reserved for issuance under this plan.  Under either plan, the exercise price of
the options may not be less than the fair market value of the shares at the time
of grant.  The  Compensation  Committee has the  authority to establish  vesting
terms, and typically provides that the options vest over a five-year period from
the date of grant. The options may be exercised,  subject to a ten-year maximum,
over a period determined by the Committee.

     In April  1992,  the  Company  also  adopted a stock  option plan which was
amended  in 1995 and 1996  and  provides  for the  grant of  nonqualified  stock
options to purchase 48,000 shares to each director who is not an employee of the
Company or its  affiliates.  A maximum of 384,000 shares of Class A Common Stock
may be issued  under this plan at a price equal to fair market value at the date
of grant.  The plan  provides  that the options  vest over a three- or five-year
period from the date of grant.

     The Company  applies APB 25 and related  interpretations  in accounting for
its plans.  Accordingly,  no compensation cost has been recognized for its stock
options plans. Had compensation cost for the Company's stock based  compensation
plans  been  determined  based on the fair  value at the grant  dates for awards
under  those  plans  consistent  with the  method  prescribed  by FAS  123,  the
Company's  net income and  earnings per share would have been reduced to the pro
forma amounts  indicated below. Note that due to the adoption of the methodology
prescribed by FAS 123, the pro forma results shown below only reflect the impact
of options granted in 1998, 1997 and 1996. Because future options may be granted
and vesting typically occurs over a five year period, the pro forma impact shown
for  1998,  1997 and 1996 is not  necessarily  representative  of the  impact in
future years.

<TABLE>
<CAPTION>


(IN THOUSANDS, EXCEPT PER SHARE DATA)           1998            1997            1996
<S>                                           <C>             <C>             <C>    
- -------------------------------------------------------------------------------------
Net income
    As reported                               $42,674         $33,429         $26,148
    Pro forma                                  38,585          32,034          25,235

Basic earnings per share
    As reported                             $    1.29       $    1.02       $    0.81
    Pro forma                                    1.16            0.98            0.78

Diluted earnings per share
    As reported                             $    1.27       $    1.01       $    0.80
    Pro forma                                    1.14            0.97            0.77

</TABLE>

     The fair value of options  granted  (which is amortized to expense over the
option vesting period in determining the pro forma impact),  is estimated on the
date of grant using the  Black-Scholes  multiple  option-pricing  model with the
following weighted average assumptions:

<TABLE>
<CAPTION>

                                 1998              1997          1996
<S>                             <C>            <C>           <C>      
- -------------------------------------------------------------------------
Expected life of option         2-7 years      2-7 years     1-6 years
Risk-free interest rate          4.1-5.9%       5.7-6.6%     5.0-6.5%
Expected volatility of stock       44%            40%         30-50%
Expected dividend yield            None           None         None

</TABLE>

     A summary of the status of the Company's  three fixed stock option plans as
of December  31,  1998,  1997 and 1996,  and changes  during the years ending on
those dates is presented below.

<TABLE>
<CAPTION>

                                                1998                      1997                           1996
                                     ---------------------------------------------------------------------------------------
                                                   Weighted-Average            Weighted-Average             Weighted-Average
                                                     Exercise                    Exercise                    Exercise
                                                      Price                        Price                       Price
(share data in thousands)                 Shares                      Shares                       Shares
<S>                                         <C>       <C>               <C>        <C>               <C>      <C>    
- ----------------------------------------------------------------------------------------------------------------------------
Outstanding at beginning of year            1,702     $17.21            1,677      $12.56            1,446    $ 10.30
Granted                                     1,866     40.65               602      22.78               642     19.85
Exercised                                   (133)     14.71             (529)       8.80             (131)         9.98
Forfeited/cancelled                         (655)     38.82              (48)      17.56             (280)     18.80
                                     =============               =============                =============
Outstanding at end of year                  2,780     28.02             1,702      17.21             1,677     12.56
                                     =============               =============                =============
Options exercisable at year end               800                         641                          756

Weighted-average fair value of
  options granted during the year          $18.07                      $ 9.91                       $ 6.57

</TABLE>

     The  following  table  summarizes  information  about fixed  stock  options
outstanding at December 31, 1998:

<TABLE>
<CAPTION>

                                         Options Outstanding                                 Options Exercisable
                     -----------------------------------------------------------    -----------------------------------
     Range of
  Exercise Prices          Number         Weighted-Average                                Number       Weighted-Average
  (SHARE DATA IN       Outstanding at        Remaining         Weighted-Average         Exercisable     Exercise Price
    THOUSANDS)            12/31/98        Contractual Life      Exercise Price          at 12/31/98
<S>           <C>                   <C>                 <C>                <C>                     <C>           <C>   
- -------------------- -----------------------------------------------------------    -----------------------------------
   $   3.25 - 15.25                 561                 5.33               $10.09                  426           $ 8.71
      15.50 - 23.50                 618                 7.15                18.64                  278            18.47
      24.50 - 35.63               1,013                 8.99                31.22                   96            26.02
      37.44 - 42.39                 218                 9.44                39.89
              55.13                 370                 9.96                55.13                    -
                     ===================                                              =================
   $   3.25 - 55.13               2,780                 8.01                28.02                  800            14.17
                     ===================                                              =================

</TABLE>

13. SEGMENT INFORMATION

     The  Company  is  organized  on the  basis  of  services  offered  and  has
determined  that  it has two  reportable  segments:  PBM  services  and  non-PBM
services (defined in Note 1 "organization and operations").  The Company manages
the  pharmacy   benefit  within  an  operating   segment  which   encompasses  a
fully-integrated PBM service. The remaining three operating service lines (IVTx,
Specialty Distribution and Vision) have been aggregated into a non-PBM reporting
segment.

     The following table presents  information about the reportable segments for
the years ended December 31:

<TABLE>
<CAPTION>

 (IN THOUSANDS)                                                   PBM                   NON-PBM               TOTAL
<S>                                                        <C>                     <C>                    <C>          
- -----------------------------------------------------------------------------------------------------------------------
 1998
Net revenues                                               $   2,765,111           $      59,761          $   2,824,872
Depreciation and amortization expense (1)                         25,540                     983                 26,433
Interest income                                                    7,235                       1                  7,236
Interest expense (1)                                              20,218                      12                 20,230
Income before income taxes                                        70,107                   6,133                 76,240
Total assets                                                   1,068,715                  26,746              1,095,461
Capital expenditures                                              23,432                     421                 23,853
- -----------------------------------------------------------------------------------------------------------------------
 1997
Net revenues                                               $   1,191,173           $      39,461          $   1,230,634
Depreciation and amortization expense                              9,704                     766                 10,470
Interest income                                                    6,080                       1                  6,081
Interest expense                                                     209                      16                    225
Income before income taxes                                        52,529                   2,177                 54,706
Total assets                                                     385,330                  17,178                402,508
Capital expenditures                                              10,782                   2,235                 13,017
- -----------------------------------------------------------------------------------------------------------------------
 1996
Net revenues                                              $      743,077           $      30,538         $      773,615
Depreciation and amortization expense                              6,273                     434                  6,707
Interest income                                                    3,509                                          3,509
Interest expense                                                      51                       8                     59
Income before income taxes                                        39,938                   3,142                 43,080
Total assets                                                     286,433                  13,992                300,425
Capital expenditures                                               8,306                   1,174                  9,480
- -----------------------------------------------------------------------------------------------------------------------
<FN>

     (1) The amortization  expense for deferred financing fees ($609 in 1998) is
included in interest expense on the Consolidated  Statement of Operations and in
depreciation and amortization on the Consolidated Statement of Cash Flows.
</FN>
</TABLE>

14. QUARTERLY FINANCIAL DATA (UNAUDITED)

     The following table  summarizes the quarterly  financial data for the years
ended December 31, 1998 and 1997:

<TABLE>
<CAPTION>

                                                                                                   Earnings Per Share
                                                            Selling,                              ---------------------            
(in thousands, except per        Net         Cost of       General &       Operating   Net
    share data                Revenues     Revenues     Administrative     Income      Income      Basic     Diluted
<S>                             <C>          <C>                <C>          <C>         <C>         <C>       <C>  
- -----------------------------------------------------------------------------------------------------------------------
 1998
March 31, 1998                   $371,362     $338,492           $18,826      $14,044     $9,878      $0.30     $0.29
June 30, 1998                     807,406      743,557            39,266       22,932      9,568       0.29      0.28
September 30, 1998                807,319      738,544            43,153       25,622     11,303       0.34      0.34
December 31, 1998                 838,784      764,403            47,745       26,636     11,924       0.36      0.35
- -----------------------------------------------------------------------------------------------------------------------
 1997
March 31, 1997                   $261,990     $237,298           $13,298      $11,394     $7,641      $0.23     $0.23
June 30, 1997                     300,515      274,906            13,733       11,876      8,131       0.25      0.25
September 30, 1997                319,937      291,590            15,758       12,589      8,613       0.26      0.26
December 31, 1997                 348,192      315,373            19,828       12,991      9,044       0.27      0.27

</TABLE>

15. SUBSEQUENT EVENT - POTENTIAL ACQUISITION

     On  February  9,  1999,  the  Company  announced  that  it had  executed  a
definitive  agreement  to purchase  Diversified  Pharmaceutical  Services,  Inc.
("DPS"), a wholly-owned subsidiary of SmithKline Beecham Corporation.  Under the
terms of the agreement,  the Company will pay cash in the amount of $700 million
for the stock of DPS. The Company expects to finance the purchase through a $1.1
billion bank credit  facility  consisting of an $800 million term facility and a
$300 million  revolving  credit facility.  In addition,  the Company has secured
bridge financing in the amount of $150 million to facilitate  closing.  The loan
proceeds will be used towards the $700 million  purchase  price and  acquisition
related  costs,  and will also be used to refinance the Company's  existing $440
million bank credit facility (see Note 6) and provide for working capital needs,
if any.  The  Company  expects  to issue $350  million  in Class A Common  Stock
through an offering.  Net proceeds  from the offering will be used to retire the
$150 million  bridge  facility and a portion of the $800 million term  facility.
The  acquisition  will be accounted for under the purchase  method of accounting
and is subject to customary closing conditions  including required  governmental
approvals and consummation and funding of the bank credit facility.  The Company
anticipates the transaction will close in the second quarter of 1999.

     Should the  transaction  close and the Company  refinance its existing $440
million bank credit facility,  the remaining unamortized deferred financing fees
will be expensed as an extraordinary item. The Company  anticipates  maintaining
its existing  interest rate swap in place to hedge the future variable  interest
rate payments on $360 million of the proposed $1.1 billion bank credit facility.

     The  following  unaudited  pro forma  information  presents  a  summary  of
combined results of operations of the Company,  the Acquired Entities and DPS as
if the acquisitions and relative  financings,  including the equity offering had
occurred at the beginning of the period presented,  along with certain pro forma
adjustments to give effect to amortization of goodwill, other intangible assets,
interest  expense  on  acquisition  debt and  other  adjustments.  The pro forma
financial information is not necessarily indicative of the results of operations
as they would have been had the transaction  been effected on the assumed dates.
Included in the pro forma  information  are  integration  costs  incurred by the
Company  for the  Acquired  Entities  that are being  reported  within  selling,
general and administrative expenses in the statement of operations.

<TABLE>
<CAPTION>

(IN THOUSANDS, EXCEPT PER SHARE DATA)       YEAR ENDED DECEMBER 31, 1998
<S>                                              <C>         
- ------------------------------------------------------------------------
Net revenues                                     $  3,449,649
Net income                                             51,130
Basic earnings per share                                 1.36
Diluted earnings per share                               1.34
</TABLE>


ITEM 9 - CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND 
          FINANCIAL DISCLOSURE

         None.


                                    PART III


ITEM 10 - DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT

     The  information  required by this item will be  incorporated  by reference
from the Company's  definitive  Proxy  Statement for its 1999 Annual  Meeting of
Stockholders  to be filed  pursuant to  Regulation  14A (the "Proxy  Statement")
under the heading "I.  Election of  Directors";  provided that the  Compensation
Committee Report on Executive  Compensation and the performance  graph contained
in the  Proxy  Statement  shall not be deemed  to be  incorporated  herein;  and
further provided that the information regarding the Company's executive officers
required  by Item  401 of  Regulation  S-K has been  included  in Part I of this
report.

ITEM 11 - EXECUTIVE COMPENSATION

     The  information  required by this item will be  incorporated  by reference
from  the  Proxy  Statement  under  the  headings   "Directors'   Compensation,"
"Compensation  Committee  Interlocks and Insider  Participation"  and "Executive
Compensation."

ITEM 12 - SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

     The  information  required by this item will be  incorporated  by reference
from the Proxy  Statement  under the  headings  "Security  Ownership  of Certain
Beneficial Owners and Management."

ITEM 13 - CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

     The  information  required by this item will be  incorporated  by reference
from the Proxy Statement under the heading  "Certain  Relationships  and Related
Transactions."

                                     PART IV

ITEM 14 - EXHIBITS, FINANCIAL STATEMENT SCHEDULES AND REPORTS ON FORM 8-K

(a) Documents filed as part of this Report

     (1) Financial Statements

     The  following  report  of  independent  accountants  and the  consolidated
financial  statements  of the Company are  contained  in this Report on the page
indicated

                                                            Page No. In
                                                             FORM 10-K

   Report of Independent Accountants                           38

   Consolidated Balance Sheet as of
       December 31, 1998 and 1997                              39

   Consolidated Statement of Operations
       for the years ended December 31, 1998,
       1997 and 1996                                           40

   Consolidated Statement of Changes in
       Stockholders' Equity for the years ended
       December 31, 1998 and 1997                              41

   Consolidated Statement of Cash Flows for
       the years ended December 31, 1998,
       1997 and 1996                                           42

   Notes to Consolidated Financial Statements                  43

     (2) The following  financial statement schedule is contained in this Report
on the page indicated.

                                                          Page No. In
Financial Statement Schedule:                              FORM 10-K

      VIII.  Valuation and Qualifying Accounts
             and Reserves for the years ended
             December 31, 1998, 1997 and 1996                   64

     All other  schedules  are omitted  because they are not  applicable  or the
required  information is shown in the consolidated  financial  statements or the
notes thereto.

     (3) List of Exhibits

          See Index to Exhibits on pages 65 - 71.

(b)  Reports on Form 8-K


        (i)      On October 27, 1998, the Company filed a
                 Current Report on Form 8-K, dated October
                 12, 1998 under Items 5 and 7, regarding a
                 press release issued on behalf of the
                 Company announcing a 2-for-1 stock split of
                 its common stock, to be effected in the form
                 of a 100% stock dividend.

        (ii)     On October 29, 1998, the Company filed a
                 Current Report on Form 8-K, dated October
                 21, 1998 under Items 5 and 7, regarding a
                 press release issued on behalf of the
                 Company concerning its third quarter 1998
                 financial performance.

        (iii)    On November 20, 1998, the Company filed a
                 Current Report on Form 8-K, dated November
                 1, 1998 under Items 5 and 7, regarding a
                 press release issued on behalf of the
                 Company announcing that the 2-for-1 split of
                 its common stock had been effected.


                                   SIGNATURES

      Pursuant to the requirements of Section 13 or 15(d) of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on
its behalf by the undersigned thereunto duly authorized.

                              EXPRESS SCRIPTS, INC.


March 24, 1999                  By:  /s/ Barrett A. Toan
                                     Barrett A. Toan, President
                                     and Chief Executive Officer

                                POWER OF ATTORNEY

     Each person whose signature  appears below hereby  constitutes and appoints
Thomas M. Boudreau,  Esq. and Keith J. Ebling, Esq., (with full power to each of
them to act alone) his or her true and lawful  attorneys-in-fact and agents, for
him or her and on his or her behalf and in his or her name,  place and stead, in
any and all capacities,  to sign any and all amendments to this Annual Report on
Form 10-K, and to file the same,  with exhibits and any and all other  documents
filed with respect thereto,  with the Securities and Exchange Commission (or any
other governmental or regulatory authority),  granting unto said attorneys,  and
each of them,  full power and  authority to do and to perform each and every act
and thing  requisite and necessary to be done in and about the premises in order
to  effectuate  the same as fully to all intents and purposes as he or she might
or could do if personally present, hereby ratifying and confirming all that said
attorneys  in fact and agents,  or any of them,  may  lawfully do or cause to be
done by virtue hereof.

     Pursuant to the  requirements of the Securities  Exchange Act of 1934, this
report  has  been  signed  below  by the  following  persons  on  behalf  of the
registrant and in the capacities and on the dates indicated.

SIGNATURE                                   TITLE                      DATE


/s/ Barrett A. Toan           President,                         March 24, 1999
Barrett A. Toan               Chief Executive
                              Officer and Director

/s/ George Paz                Senior Vice President and          March 24, 1999
George Paz                    Chief Financial Officer


/s/ Joseph W. Plum            Vice President and                 March 24, 1999
Joseph W. Plum                Chief Accounting Officer

                              Director                           March __, 1999
Howard I. Atkins

/s/ Judith E. Campbell        Director                           March 24, 1999
Judith E. Campbell

                              Director                           March __, 1999
Richard M. Kernan, Jr.

/s/ Richard A. Norling        Director                           March 24, 1999
Richard A. Norling

                              Director                           March __, 1999
Frederick J. Sievert

/s/ Stephen N. Steinig        Director                           March 24, 1999
Stephen N. Steinig

/s/ Seymour Sternberg         Director                           March 24, 1999
Seymour Sternberg

/s/ Howard L. Waltman         Director                           March 24, 1999
Howard L. Waltman

/s/ Norman Zachary            Director                           March 24, 1999
Norman Zachary


                              EXPRESS SCRIPTS, INC.
              Schedule VIII - Valuation and Qualifying Accounts and
                  Reserves Years Ended December 31, 1996, 1997
                                    and 1998
<TABLE>
<CAPTION>


COL. A                 COL. B                 COL. C                COL.D        COL. E
                                            Additions
                    Balance             Charges    Charges                       Balance
                         at             to Costs   to Other                      at End
                    Beginning             and         and                          of
Description         Of period           Expenses   Accounts      (Deductions)    Period
<S>        <C>      <C>              <C>                        <C>             <C>         
- ---------------------------------------------------------------------------------------------
Allowance for 
Doubtful Accounts 
Receivable

Year Ended 12/31/96  $2,273,937       $1,456,130                 $  1,394,922    $  2,335,145
Year Ended 12/31/97  $2,335,145       $3,680,409                 $  1,213,991    $  4,801,563
Year Ended 12/31/98  $4,801,563       $4,583,008  $9,570,069(1)  $  1,148,356    $ 17,806,284

<FN>
     1 Represents  the opening  balance  sheet for the  Company's  April 1, 1998
acquisition of ValueRx.
</FN>
</TABLE>


<PAGE>

                                INDEX TO EXHIBITS
            (Express Scripts, Inc. - Commission File Number 0-20199)

Exhibit
Number         Exhibit

2.1            Stock Purchase Agreement by and among Columbia/HCA Healthcare 
               Corporation, VH Holdings, Inc., Galen Holdings, Inc. and Express
               Scripts, Inc., dated as of February 19, 1998, and certain related
               Schedules, incorporated by reference to Exhibit No. 2.1 to the 
               Company's Current Report on Form 8-K filed March 2, 1998.

2.2            First Amendment to Stock Purchase Agreement by and among 
               Columbia/HCA Healthcare Corporation, VH Holdings, Inc., Galen 
               Holdings, Inc. and Express Scripts, Inc., dated as of
               March 31, 1998, and related Exhibits incorporated by reference
               to Exhibit No. 2.1 to the Company's Current Report on Form 8-K 
               filed April 14, 1998.

2.3            Stock Purchase Agreement by and among SmithKline Beecham
               Corporation, SmithKline Beecham InterCredit BV and Express
               Scripts, Inc., dated as of February 9, 1999, and certain related
               Schedules, incorporated by reference to Exhibit No. 2.1 to the
               Company's Current Report on Form 8-K filed February 18, 1999.

3.1            Certificate of Incorporation, incorporated by reference to 
               Exhibit No. 3.1 to the Company's Registration Statement on 
               Form S-1 filed June 9, 1992 (No. 33-46974) (the "Registration
               Statement").

3.2            Certificate of Amendment of the Certificate of Incorporation of
               the Company, incorporated by reference to Exhibit No.10.6 to the
               Company's Quarterly Report on Form 10-Q for the quarter ending 
               June 30, 1994.

3.3*           Certificate of Amendment of the Certificate of Incorporation of 
               the Company.

3.4            Second Amended and Restated Bylaws, incorporated by reference to
               Exhibit No. 3.3 to the Company's Quarterly Report on Form 10-Q 
               for the quarter ending September 30, 1997.

4.1            Form of Certificate for Class A Common Stock, incorporated by 
               reference to Exhibit No. 4.1 to the Registration Statement.

10.1**         Stock Agreement (Initial Shares) entered into as of December 31,
               1995, between the Company and American Healthcare Purchasing
               Partners, L.P., incorporated by reference to Exhibit No. 10.61 to
               the Company's Annual Report on Form 10-K for the year ending
               1995.

10.2**         Stock Agreement (Membership Shares) entered into as of December
               31, 1995, between the Company and American Healthcare Purchasing
               Partners, L.P., incorporated by reference to Exhibit No. 10.62 to
               the Company's Annual Report on Form 10-K for the year ending
               1995.

10.3**         Amended and Restated Agreement entered into as of March 29, 1995,
               between the Company and Sanus Corp. Health Systems, incorporated
               by reference to Exhibit No. 10.1 to the Company's Annual Report
               on Form 10-K for the year ending 1995.

10.4**         Form of Amended and Restated Managed Prescription Drug Program
               Agreement entered into as of March 29, 1995, between the Company
               and each of the following parties: Health Plus, Inc., Sanus
               Health Plan of New Jersey, Inc., Sanus Texas Health Plan, Inc.,
               Sanus/New York Life Health Plan, Inc., Sanus Health Plan of
               Illinois, Inc. and Sanus Health Plan of Greater New York, Inc.,
               incorporated by reference to Exhibit No. 10.2 to the Company's
               Annual Report on Form 10-K for the year ending 1995.

10.5**         Managed Prescription Drug Program Agreement dated as of May 1,
               1996 by and between the Company and NYLCare Health Plans of
               Maine, Inc., incorporated by reference to Exhibit No. 10.3 to the
               Company's Quarterly Report on Form 10-Q for the quarter ending
               March 31, 1997.

10.6**         Managed Prescription Drug Program Agreement dated as of December
               31, 1995 by and between the Company and WellPath Community Health
               Plan, Inc., incorporated by reference to Exhibit No. 10.2 to the
               Company's Quarterly Report on Form 10-Q for the quarter ending
               March 31, 1997.

10.7**         Form of Amended and Restated Vision Program Sponsor Agreement
               entered into as of March 29, 1995, between the Company and each
               of the following parties: Health Plus, Inc., Sanus Health Plan of
               New Jersey, Inc., Sanus Texas Health Plan, Inc., Sanus/New York
               Life Health Plan, Inc., Sanus Health Plan of Illinois, Inc. and
               Sanus Health Plan of Greater New York, Inc., incorporated by
               reference to Exhibit No. 10.3 to the Company's Annual Report on
               Form 10-K for the year ending 1995.

10.8**         Form of Amended and Restated Infusion Therapy Agreement entered
               into as of March 29, 1995, between the Company and each of the
               following parties: Health Plus, Inc., Sanus Texas Health Plan,
               Inc., Sanus/New York Life Health Plan, Inc., and Sanus Health
               Plan of Illinois, Inc., incorporated by reference to Exhibit No.
               10.4 to the Company's Annual Report on Form 10-K for the year
               ending 1995.

10.9**         Form of Infusion Therapy Agreement entered into as of March 29, 
               1995, between the Company and each of the following parties:  
               Sanus Health Plan of New Jersey, Inc. and Sanus Health
               Plan of Greater New York, Inc., incorporated by reference to 
               Exhibit No. 10.5 to the Company's Annual Report on Form 10-K for
               the year ending 1995.

10.10          First Amendment to Vision Program Sponsor Agreement entered into
               as of September 1, 1995, between the Company and Sanus Health
               Plan of New Jersey, Inc., incorporated by reference to Exhibit
               No. 10.6 to the Company's Annual Report on Form 10-K for the year
               ending 1995.

10.11          First Amendment to the Amended and Restated Vision Program 
               Sponsor Agreement entered into as of November 1, 1995, between 
               the Company and Sanus Texas Health Plan, Inc., incorporated
               by reference to Exhibit No. 10.7 to the Company's Annual Report 
               on Form 10-K for the year ending 1995.

10.12          Agreement dated January 1, 1989, as amended May 31, 1989, and 
               January 1, 1991, between the Company and New York Life Insurance
               Company, incorporated by reference to Exhibit No. 10.20
               to the Registration Statement.

10.13          Third Amendment dated as of July 30, 1993, to the Agreement dated
               as of January 1, 1989, by and between the Company and New York
               Life Insurance Company, incorporated by reference to Exhibit No.
               10.16 to the Company's Quarterly Report on Form 10-Q for the
               quarter ending September 30, 1993.

10.14          Amended and Restated Managed Prescription Drug Program Agreement
               entered into as of September 1, 1995, between the Company and 
               New York Life Insurance Company, incorporated by
               reference to Exhibit No. 10.24 to the Company's Annual Report on
               Form 10-K for the year ending 1995.

10.15**        First Amendment to Amended and Restated Managed Prescription Drug
               Program Agreement and Consent to Assignment dated as of January
               1, 1997, by and between the Company, New York Life Insurance
               Company and NYLCare Health Plans, Inc., incorporated by reference
               to Exhibit No. 10.1 to the Company's Quarterly Report on Form
               10-Q for the quarter ending March 31, 1997.

10.16          Quota-Share Reinsurance Agreement executed as of August 15, 1994,
               between New York Life Insurance Company and Great Plains
               Reinsurance Company, incorporated by reference to Exhibit 10.1 to
               the Company's Quarterly Report on Form 10-Q for the quarter
               ending September 30, 1994.

10.17          Amendment No. 1 to Quota-Share Reinsurance Agreement dated as of
               September 13, 1994, between New York Life Insurance Company and
               Great Plains Reinsurance Company, incorporated by reference to
               Exhibit 10.2 to the Company's Quarterly Report on Form 10-Q for
               the quarter ending September 30, 1994.

10.18          Joint Research Agreement dated June 28, 1994, by and between the
               Company, Sanus Corp.Health Systems and Schering Corporation, 
               incorporated by reference to Exhibit 10.4 to the Company's 
               Quarterly Report on Form 10-Q for the quarter ending 
               September 30, 1994.

10.19          Agreement dated May 7, 1992, between the Company and New York 
               Life Insurance Company, incorporated by reference to Exhibit 
               No. 10.26 to the Registration Statement.

10.20          Lease Agreement dated March 3, 1992, between Riverport, Inc. and
               Douglas Development Company--Irvine Partnership in commendam and
               the Company, incorporated by reference to Exhibit No. 10.21 to 
               the Registration Statement.

10.21          First Amendment to Lease dated as of December 29, 1992, between
               Sverdrup/MDRC Joint Venture and the Company, incorporated by 
               reference to Exhibit No. 10.13 to the Company's Quarterly
               Report on Form 10-Q for the quarter ending June 30, 1993.

10.22          Second Amendment to Lease dated as of May 28, 1993, between 
               Sverdrup/MDRC Joint Venture and the Company, incorporated by 
               reference to Exhibit No. 10.14 to the Company's Quarterly
               Report on Form 10-Q for the quarter ending June 30, 1993.

10.23          Third Amendment to Lease entered into as of October 15, 1993, by
               and between Sverdrup/MDRC Joint Venture and the Company,
               incorporated by reference to Exhibit No. 10.69 to the Company's
               Annual Report on Form 10-K for the year ending 1993.

10.24          Fourth Amendment to Lease dated as of March 24, 1994, by and 
               between Sverdrup/MDRC Joint Venture and the Company, 
               incorporated by reference to Exhibit No. 10.70 to the Company's
               Annual Report on Form 10-K for the year ending 1993.

10.25          Fifth Amendment to Lease made and entered into June 30, 1994, 
               between Sverdrup/MDRC Joint Venture and the Company, 
               incorporated by reference to Exhibit 10.1 to the Company's
               Quarterly Report on Form 10-Q for the quarter ending June 30,
               1994.

10.26          Sixth Amendment to Lease made and entered into January 31, 1995,
               between Sverdrup/MDRC Joint Venture and the Company, incorporated
               by reference to Exhibit No. 10.70 to the Company's Annual Report
               on Form 10-K for the year ending 1994.

10.27          Seventh Amendment to Lease dated as of August 14, 1998, by and
               between Duke Realty Limited Partnership, by and through its
               general partner, Duke Realty Investments, Inc., and the Company,
               incorporated by reference to Exhibit No. 10.3 to the Company's
               Quarterly Report on Form 10-Q for the quarter ending September
               30, 1998.

10.28          Eighth Amendment to Lease dated as of August 14, 1998, by and
               between Duke Realty Limited Partnership, by and through its
               general partner, Duke Realty Investments, Inc., and the Company,
               incorporated by reference to Exhibit No. 10.4 to the Company's
               Quarterly Report on Form 10-Q for the quarter ending September
               30, 1998.

10.29*         Ninth Amendment to Lease dated as of February 19, 1999, by and
               between Duke Realty Limited Partnership, by and through its
               general partner, Duke Realty Investments, Inc., and the Company.

10.30          Single-Tenant Lease-Net entered into as of June 30, 1993, 
               between James M. Chamberlain, Trustee of Chamberlain Family 
               Trust dated September 21, 1979, and the Company, incorporated
               by reference to Exhibit No. 10.16 to the Company's Form 10-Q for
               the quarter ending June 30, 1993.

10.31          First Amendment to Single-Tenant Lease-Net entered into as of 
               November 12, 1993, by and between James M. Chamberlain, Trustee 
               of Chamberlain Family Trust, and the Company, incorporated by 
               reference to Exhibit No. 10.74 to the Company's Annual Report on
               Form 10-K for the year ending 1993.

10.32          Earth City Industrial Office/Warehouse Lease Agreement dated as
               of August 19, 1996, by and between the Company and Louis 
               Siegfried Corporation, incorporated by reference to Exhibit
               No. 10.1 to the Company's Quarterly Report on Form 10-Q for the
               quarter ending September 30, 1996.

10.33          Lease Agreement dated as of June 12, 1989, between Michael D.
               Brockelman and James S. Gratton, as Trustees under agreement
               dated April 17, 1980, and Health Care Services, Inc., an indirect
               subsidiary of the Company, incorporated by reference to Exhibit
               No. 10.7 to the Company's Quarterly Report on Form 10-Q for the
               quarter ending June 30, 1998.

10.34          Lease Agreement dated as of March 22, 1996, between Ryan
               Construction Company of Minnesota, Inc., and ValueRx Pharmacy
               Program, Inc., an indirect subsidiary of the Company,
               incorporated by reference to Exhibit No. 10.8 to the Company's
               Quarterly Report on Form 10-Q for the quarter ending June 30,
               1998.

10.35          Lease Extension and Amendment Agreement dated as of July 24,
               1998, between Faith A. Griefen and ValueRX Pharmacy Program,
               Inc., an indirect subsidiary of the Company, incorporated by
               reference to Exhibit No. 10.1 to the Company's Quarterly Report
               on Form 10-Q for the quarter ending September 30, 1998.

10.36          Office Lease dated as of August 14, 1998 by and between Duke 
               Realty Limited Partnership, by and through its general partner, 
               Duke Realty Investments, Inc., and the Company, incorporated by 
               reference to Exhibit No. 10.2 to the Company's Quarterly Report
               on Form 10-Q for the quarter ending September 30, 1998.

10.37*         Second Lease Amendment dated as of December 31, 1998 by and
               between Duke Realty Limited Partnership, by and through its
               general partner, Duke Realty Investments, Inc., and the Company.

10.38***       Express Scripts, Inc. 1992 Stock Option Plan, incorporated by 
               reference to Exhibit No.10.23 to the Registration Statement.

10.39***       Express Scripts, Inc. Stock Option Plan for Outside Directors, 
               incorporated by reference to Exhibit No. 10.24 to the 
               Registration Statement.

10.40***       Express Scripts, Inc. 1994 Stock Option Plan, incorporated by 
               reference to Exhibit No. 10.4 to the Company's Quarterly Report
               on Form 10-Q for the quarter ending June 30, 1994.

10.41***       Amended and Restated Express Scripts, Inc. 1992 Employee Stock 
               Option Plan, incorporated by reference to Exhibit No. 10.78 to 
               the Company's Annual Report on Form 10-K for the year
               ending 1994.

10.42***       Amended and Restated Express Scripts, Inc. Stock Option Plan for
               Outside Directors, incorporated by reference to Exhibit No. 
               10.79 to the Company's Annual Report on Form 10-K for the year 
               ending 1994.

10.43***       First Amendment to Express Scripts, Inc. Amended and Restated 
               1992 Stock Option Plan for Outside Directors incorporated by 
               reference to Exhibit A to the Company's Proxy Statement
               dated April 9, 1996.

10.44***       Amended and Restated Express Scripts, Inc. 1994 Stock Option 
               Plan  incorporated by reference to Exhibit No. 10.80 to the 
               Company's Annual Report on Form 10-K for the year
               ending 1994.

10.45***       First Amendment to Express Scripts, Inc. Amended and Restated 
               1994 Stock Option Plan incorporated by reference to Exhibit A to
               the Company's Proxy Statement dated April 16, 1997.

10.46***       Second Amendment to Express Scripts, Inc. Amended and Restated 
               1994 Stock Option Plan incorporated by reference to Exhibit A to
               the Company's Proxy Statement dated April 21, 1998.

10.47***       Employment Agreement dated April 30, 1992, between the Company 
               and Barrett A. Toan (including form of Non-Qualified Stock 
               Option Agreement), incorporated by reference to
               Exhibit No. 10.25 to the Registration Statement.

10.48***       Letter Agreement amending Employment Agreement dated 
               February 28, 1996, from the Company to
               Barrett A. Toan, incorporated by reference to Exhibit No. 10.51
               to the Company's Annual Report on Form 10-K for the year ending 
               1995.

10.49***       Form of Severance Agreement dated as of January 27, 1998, 
               between the Company and each of the following individuals: 
               Stuart L. Bascomb, Thomas M. Boudreau, Robert W. Davis, Linda L.
               Logsdon, David A. Lowenberg, and George Paz, and Patrick J. 
               Byrne (agreement dated as of May 29, 1998), Michael S. Flagstad
               (agreement dated as of April 1, 1998), and Jean-Marc
               Quach (agreement dated as of May 18, 1998); incorporated by 
               reference to Exhibit No. 10.70 to the Company's Annual Report 
               on Form 10-K for the year ending December 31, 1997.

10.50          Credit Agreement dated as of April 1, 1998 among the Company, 
               the Lenders listed therein and Bankers Trust Company, as Agent
               (the "Credit Agreement"), incorporated by reference to
               Exhibit No. 10.1 to the Company's Quarterly Report on Form 10-Q 
               for the quarter ending June 30, 1998.

10.51          Company Pledge Agreement dated as of April 1, 1998 by the 
               Company in favor of the Lenders listed in the Credit Agreement 
               and Bankers Trust Company, as Agent incorporated by reference to
               Exhibit No. 10.2 to the Company's Quarterly Report on Form 10-Q
               for the quarter ending June 30, 1998.

10.52          Form of Subsidiary Guaranty dated as of April 1, 1998 in favor 
               of the Lenders listed in the Credit Agreement and Bankers Trust
               Company, as Agent, by the following parties: Express Scripts
               Vision Corporation, PhyNet, Inc., IVTx, Inc., IVTx of Dallas,
               Inc., IVTx of Houston, Inc., ESI Canada Holdings, Inc., ESI
               Canada, Inc., Value Health, Inc., Managed Prescription Network,
               Inc., Prescription Drug Service, Inc., RxNet, Inc. of California,
               Denali Associates, Inc., ValueRx Northeast, Inc., MedCounter,
               Inc., Health Care Services, Inc., ValueRx, Inc., Cost Containment
               Corp. of America, Diagnostek, Inc., MedIntell Systems
               Corporation, ValueRx Pharmacy Program, Inc., ValueRx of Michigan,
               Inc., Diagnostek Pharmacy Services, Inc., Diagnostek Pharmacy,
               Inc., Diagnostek of Springfield, Inc., IPH, Inc., and MHI, Inc.,
               incorporated by reference to Exhibit No. 10.3 to the Company's
               Quarterly Report on Form 10-Q for the quarter ending June 30,
               1998.

10.53          Form of Subsidiary Pledge Agreement dated as of April 1, 1998 in
               favor of the Lenders listed in the Credit Agreement and Bankers
               Trust Company, as Agent, by the following parties: ESI Canada
               Holdings, Inc., Value Health, Inc., ValueRx, Inc., Diagnostek,
               Inc., ValueRx Pharmacy Program, Inc., Diagnostek Pharmacy
               Services, Inc., and IPH, Inc., incorporated by reference to
               Exhibit No. 10.4 to the Company's Quarterly Report on Form 10-Q
               for the quarter ending June 30, 1998.

10.54          First Amendment to Company Pledge Agreement dated as of April 24,
               1998, by the Company by the Company in favor of the Lenders
               listed in the Credit Agreement and Bankers Trust Company, as
               Agent, incorporated by reference to Exhibit No. 10.5 to the
               Company's Quarterly Report on Form 10-Q for the quarter ending
               June 30, 1998.

10.55          International Swap Dealers Association, Inc. Master Agreement 
               dated as of April 3, 1998, between the Company and The First 
               National Bank of Chicago, incorporated by reference to
               Exhibit No. 10.6 to the Company's Quarterly Report on Form 10-Q 
               for the quarter ending June 30, 1998.

10.56***       Express Scripts, Inc. Employee Stock Purchase Plan incorporated 
               by reference to Exhibit No. 4.1 to the Company's Registration 
               Statement on Form S-8 filed December 29, 1998.

10.57***       Express Scripts, Inc. Executive Deferred Compensation Plan 
               incorporated by reference to Exhibit No. 4.1 to the Company's 
               Registration Statement on Form S-8 filed February 16, 1999.

21.1*          List of Subsidiaries.

23.1*          Consent of PricewaterhouseCoopers LLP.

24.1*          Power of Attorney (included in Signature Page).

27.1*          Financial Data Schedule (provided for the information of the 
               U.S. Securities and Exchange Commission only).


*      Filed herein.
**     Confidential treatment granted for certain portions of these exhibits.
***    Management contract or compensatory plan or arrangement.
****   Confidential treatment requested for certain portions of these exhibits.



                                  EXHIBIT 3.3

                            CERTIFICATE OF AMENDMENT
                                     OF THE
                          CERTIFICATE OF INCORPORATION
                                       OF
                              EXPRESS SCRIPTS, INC.

     Express  Scripts,  Inc. (the  "Corporation"),  a corporation  organized and
existing  under  and by virtue of the  General  Corporation  Law of the State of
Delaware, DOES HEREBY CERTIFY

     FIRST: That the Board of Directors of the Corporation at a meeting duly
called and held adopted resolutions proposing and declaring advisable an
amendment to the Certificate of Incorporation of the Corporation, as follows:

     RESOLVED,  that the Board of  Directors  hereby  proposes  and  declares it
advisable  that the  first  paragraph  of  Article  Four of the  Certificate  of
Incorporation of the Corporation be amended to read in its entirety as follows:

     4. The total number of shares of stock which the  Corporation has authority
to issue is  102,000,000  shares,  of which (i)  5,000,000  shares are preferred
stock,  par value $0.01 per share (the "Preferred  Stock"),  and (ii) 97,000,000
shares are  common  stock,  consisting  of  75,000,000  shares of Class A Common
Stock,  par value $0.01 per share (the "Class A Common  Stock"),  and 22,000,000
shares of Class B Common  Stock,  par value $0.01 per share (the "Class B Common
Stock").

     SECOND:  That thereafter at a meeting of stockholders duly called and held,
a  majority  of the votes of the  outstanding  Class A Common  Stock and Class B
Common Stock of the  Corporation  entitled to vote thereon voting  together as a
single  class,  and a majority  of the votes of the  outstanding  Class A Common
Stock and Class B Common  Stock  entitled  to vote  thereon  voting as  separate
classes, were voted in favor of the amendment.

     THIRD:  That  said  amendment  was  duly  adopted  in  accordance  with the
provisions  of  Section  242 of the  General  Corporation  Law of the  State  of
Delaware.

     IN WITNESS WHEREOF,  Express Scripts, Inc. has caused its corporate seal to
be hereunto  affixed and this  Certificate  to be signed by Barrett A. Toan, its
President and Chief Executive Officer,  and attested by Thomas M. Boudreau,  its
Secretary, this 3rd day of June, 1998.

                                    Express Scripts, Inc.

                                     By: /s/ Barrett A. Toan
                                         Barrett A. Toan, President and
                                         Chief Executive Officer

ATTEST:

[Corporate Seal]

/s/ Thomas M. Boudreau
Thomas M. Boudreau, Secretary


                                 EXHIBIT 10.29

                              NINTH LEASE AMENDMENT

     THIS NINTH LEASE  AMENDMENT  (the "Ninth  Amendment") is executed this 19th
day of February, 1999 by and between DUKE REALTY LIMITED PARTNERSHIP, an Indiana
limited  partnership,  ("Landlord"),  and  EXPRESS  SCRIPTS,  INC.,  a  Delaware
corporation, ("Tenant")

                              W I T N E S S E T H :

     WHEREAS,   Riverport,   Inc.  and  Douglas  Development  Company  -  Irvine
Partnership  in Commendam  (collectively,  the "Original  Landlord")  and Tenant
entered into a lease dated March 3, 1992  (including  all Exhibits,  Addenda and
Amendments   thereto,   the   "Lease")   for  a  certain   64,000   square  foot
office/warehouse  building located at 14042 Riverport Drive, St. Louis, Missouri
63043 (the "Building");

     WHEREAS, in November,  1992,  Original Landlord  transferred all its right,
title, and interest in the Building to Sverdrup/MDRC  Joint Venture  ("Successor
Landlord") and said Successor Landlord assumed all of Original Landlord's duties
and obligations under the Lease;

     WHEREAS,  Successor  Landlord and Tenant entered into a First  Amendment to
Lease dated  December 29, 1992 (the "First  Amendment"),  a Second  Amendment to
Lease dated May 28, 1993 (the "Second  Amendment"),  a Third  Amendment to Lease
dated  October 15, 1993 (the "Third  Amendment"),  a Fourth  Amendment  to Lease
dated March 24, 1994 (the "Fourth Amendment"),  a Fifth Amendment to Lease dated
June 30, 1994 (the "Fifth Amendment"),  a Sixth Amendment to Lease dated January
31, 1995 (the "Sixth Amendment"),  a Seventh Amendment to Lease dated August 14,
1998 (the "Seventh  Amendment"),  and an Eighth  Amendment to Lease dated August
14, 1998 (the "Eight Amendment");

     WHEREAS, pursuant to the Third Amendment, Landlord agreed to rent to Tenant
and Tenant agreed to lease from  Landlord an additional  12,365 square feet (the
"Additional Space");

     WHEREAS,  pursuant to the Fifth Amendment,  Landlord and Tenant agreed that
the  Additional  Space was no longer a part of the Premises,  and that the Third
Amendment  would  constitute  a lease of and by itself  (the  "Additional  Space
Lease")  standing  on its own terms  and  consisting  of all the same  terms and
conditions as were  contained in the Lease (except to the extent that such terms
and  conditions  relate  solely and  expressly to the Premises) and in the Third
Amendment;

     WHEREAS, on or about September 26, 1997, Successor Landlord transferred all
of its right,  title and interest under the Lease and in and to the Premises and
in and to the Additional Space Lease to Landlord;

     WHEREAS,  pursuant to the Seventh  Amendment,  the termination  date of the
Additional  Space Lease was extended  from  December 1, 1998 to the later of (i)
August  1,  1999 or (ii)  the  date  which  is sixty  (60)  days  following  the
Commencement  Date (as defined in the Office Lease  referenced and identified in
the Seventh Amendment) of the Office Lease;

     WHEREAS,  Tenant desires to extend the term of the  Additional  Space Lease
until December 31, 2000; and

     WHEREAS,  Landlord and Tenant  desire to amend  certain  provisions  of the
Additional Space Lease to reflect such extension;

     NOW  THEREFORE,  in  consideration  of the foregoing  premises,  the mutual
covenants  herein  contained  and each act  performed  hereunder by the parties,
Landlord and Tenant hereby enter into this Ninth Amendment and agree as follows:

     1.  TERMINATION  DATE. The termination  date of the Additional  Space Lease
(but said lease only) is hereby extended to December 31, 2000.

     2. ADDITIONAL  SPACE RENT.  Commencing on January 1, 2000, and on the first
day of each  calendar  month  thereafter  during the course of the tenancy  with
respect to the  Additional  Space,  Tenant shall pay to Landlord as Base Rent an
amount equal to $5,873.38 instead of $4,585.35.

     3. CONDITION OF PREMISES. Upon the expiration or earlier termination of the
Additional Space Lease,  Tenant shall return the Additional Space in broom clean
condition,  normal wear and tear, Tenant's improvements (as defined in the Third
Amendment),  other  non-structural  improvements and modifications,  and loss by
fire or other casualty excepted.

     4. OPTION TO EXTEND.

     A. GRANT AND  EXERCISE  OF  OPTION.  This  Option to Extend  applies to the
Additional  Space Lease only.  Provided  that (i) Tenant has not been in default
hereunder  at any  time  during  the Term of the  Additional  Space  Lease  (the
"Original  Additional Space Term"),  (ii) Tenant originally named herein remains
in possession of and has been  continuously  operating in the  Additional  Space
throughout  the  Original  Additional  Space Term and (iii)  Tenant's use of the
Additional  Space  remains  the same as  designated  in Section XI of the Lease,
Tenant  shall have one (1) option to extend the Original  Additional  Space Term
for one (1)  additional  period  of  three  (3)  years  (the  "Additional  Space
Extension  Term").  The Additional  Space  Extension Term shall be upon the same
terms and conditions  contained in the  Additional  Space Lease for the Original
Additional  Space Term except (i) Tenant  shall not have any  further  option to
extend and (ii) the  Minimum  Annual  Base Rent shall be  adjusted  as set forth
herein ("Rent  Adjustment").  Tenant shall exercise such option by delivering to
Landlord,  no later than April 1, 2000,  written  notice of  Tenant's  desire to
extend the Original Additional Space Term. Tenant's failure to properly exercise
such option shall waive it. If Tenant  properly  exercises its option to extend,
Landlord  shall notify Tenant in writing,  within twenty (20) days of receipt by
Landlord of Tenant's said notice, of Landlord's  proposed  Effective Market Base
Rent Rate (as hereinafter  defined) and Landlord's  proposed Minimum Annual Base
Rent for the Additional  Space  Extension  Term.  The Minimum  Monthly Base Rent
shall be an amount equal to  one-twelfth  (1/12) of the Minimum Annual Base Rent
for the Additional  Space  Extension Term and shall be paid at the same time and
in the same manner as provided in the Additional Space Lease. If Tenant properly
exercises  its option to extend,  Landlord and Tenant shall execute an amendment
to the Lease (or, at Landlord's  option, a new lease on the form then in use for
the  Building)  reflecting  the terms and  conditions  of the  Additional  Space
Extension Term.

     B. RENT  ADJUSTMENT.  The Minimum Annual Base Rent for the Additional Space
Extension  Term shall be an amount  equal to  ninety-five  percent  (95%) of the
projected  Effective Market Base Rent Rate, as at the  commencement  date of the
Additional Space Extension Term which said Effective Market Base Rent Rate shall
be the rate  charged to tenants  for space of  comparable  size,  location,  and
conditions in comparable property within a five (5) mile radius of the Building.
Said  Effective  Market  Base  Rent  Rate  shall  take  into  consideration  the
following:  location,  quality,  age,  common area factors,  finish  allowances,
rental abatement,  parking charges, lease assumptions,  moving allowances, space
planning  allowances,  refurbishment  allowances,  and any other  concession  or
inducement.  In addition, other consideration such as credit standing of Tenant,
lease term,  and any other issues that would be relevant in making a market rate
determination  should be considered.  If Landlord and Tenant should be unable to
agree  as to the  Effective  Market  Base  Rent  Rate for the  Additional  Space
Extension  Term within twenty (20) days of receipt by Tenant of Landlord's  said
notice,  then  Landlord  and Tenant  shall each select a  qualified  real estate
appraiser (as hereinafter  defined) to determine the Effective  Market Base Rent
Rate.  Said  appraisers  shall render their written  decision within twenty (20)
days  after the date of their  selection.  If the  difference  between  the high
appraisal  and  the  low  appraisal  is ten  percent  (10%)  or  less of the low
appraisal, then the Effective Market Base Rent Rate shall be the average between
the low  appraisal and the high  appraisal and the Minimum  Annual Base Rent for
the Additional Space Extension Term shall be ninety-five  percent (95%) thereof.
In the  event  said  difference  is in  excess of ten  percent  (10%),  then the
appraisers  shall mutually  select a third  appraiser who shall render a written
decision  of the  Effective  Market  Base Rent Rate  within  twenty (20) days of
his/her  selection.  The Minimum  Annual Base Rent during the  Additional  Space
Extension Term shall be ninety-five  percent (95%) of the Effective  Market Base
Rent Rate as established by the third appraiser;  provided,  however,  that said
Effective  Market  Base Rent Rate shall not be  greater  than the  initial  high
appraisal or be less than the initial low appraisal nor shall the Minimum Annual
Base Rent for the  Additional  Space  Extension  Term be less  than the  Minimum
Annual Base Rent payable by Tenant to Landlord as of the Termination Date of the
immediately  preceding Original Additional Space Term. In the event that the two
appraisers  fail or refuse to select a third  appraiser,  either  party may make
application,  upon written notice to the other, to the Chief Judge of the United
States District Court for the Eastern  District of Missouri,  Eastern  Division,
who shall  select  the third  appraiser.  Either  party  may,  within  three (3)
business days of the making of application to the Chief Judge,  submit a list of
not more than five (5) qualified (as herein  specified)  real estate  appraisers
for the guidance of the Chief Judge. Each party shall pay the appraiser selected
by it and the costs of the third  appraiser,  if any,  shall be borne equally by
Landlord  and Tenant.  If it shall  become  necessary  to select  appraisers  in
accordance with the terms of this Section 4.B, said  appraisers  shall be either
(i) a  disinterested  commercial real estate broker with at least ten (10) years
professional  experience  in the St.  Louis,  Missouri  metropolitan  industrial
market or (ii) a disinterested  person with at least ten (10) years professional
experience  in  commercial  real estate  appraisal  in the St.  Louis,  Missouri
metropolitan  area,  and a  member  in  good  standing  in at  least  one of the
following  professional  organizations:  The Society of Real  Estate  Appraisers
(holding  the  SREA  designation),  or the  American  Institute  of Real  Estate
Appraisers (holding the MAI designation).

     5. EXAMINATION OF AMENDMENT.  Submission of this instrument for examination
or signature to Tenant does not  constitute a reservation  or option,  and it is
not effective until execution by and delivery to both Landlord and Tenant.

     6. DEFINITIONS.  Except as otherwise provided herein, the capitalized terms
used in this Ninth Amendment shall have the definitions set forth in the Lease.

     7. INCORPORATION.  This Ninth Amendment shall be incorporated into and made
a part of the Additional Space Lease, and all provisions of the Additional Space
Lease not  expressly  modified or amended  hereby shall remain in full force and
effect.

     IN WITNESS  WHEREOF,  the parties  have caused this Ninth  Amendment  to be
executed on the day and year first above written.

                             LANDLORD:

                             DUKE REALTY LIMITED PARTNERSHIP,
                             an Indiana limited partnership

                             By:      Duke Realty Investments, Inc.,
                                      its General Partner
ATTEST:

/s/ James D. Echoff                    By: /s/ Ramsey F. Maune
Corporate Attorney                          Ramsey F. Maune
and Vice President                          Vice President and General Manager
                                            St. Louis Industrial Group

                              TENANT:

                              EXPRESS SCRIPTS, INC., a Delaware
                              corporation

ATTEST:                       By: /s/ Thomas M. Boudreau
                                   Thomas M. Boudreau
/s/ Keith J. Ebling                Senior Vice President and General Counsel
Secretary

         

STATE OF MISSOURI   )
                    ) SS:
COUNTY OF ST. LOUIS )

     Before me, a Notary  Public in and for said  County  and State,  personally
appeared  Thomas M.  Boudreau,  by me known  and by me known to be the Sr.  Vice
President of Express Scripts,  Inc., a Delaware corporation who acknowledged the
execution of the foregoing Ninth Amendment on behalf of said corporation.

     WITNESS my hand and Notarial Seal this 9th day of February, 1999.

                                        /s/ Kathleen M. Dolan
                                              Notary Public

                                             Kathleen M. Dolan
                                             (Printed Signature)

My Commission Expires: 4/14/2001
          
My County of Residence: St. Louis County

STATE OF MISSOURI   )
                    ) SS:
COUNTY OF ST. LOUIS )

     Before me, a Notary  Public in and for said  County  and State,  personally
appeared  Ramsey F. Maune,  by me known and by me known to be the Vice President
and  General   Manager-St.   Louis  Industrial  Group  of  Duke  Realty  Limited
Partnership,  an Indiana limited  partnership who  acknowledged the execution of
the foregoing Ninth Amendment on behalf of said corporation.

     WITNESS my hand and Notarial Seal this 19th day of February, 1999.


                                        /s/ Kathleen M. Wade
                                             Notary Public

                                        Kathleen M. Wade
                                        (Printed Signature)

My Commission Expires:5/4/2002

My County of Residence: St. Louis County


                                 EXHIBIT 10.37

                             SECOND LEASE AMENDMENT

     This SECOND LEASE AMENDMENT (the "Second Amendment") is executed as of this
31st day of December,  1998, by and between DUKE REALTY LIMITED PARTNERSHIP,  an
Indiana limited  partnership,  by and through its general  partner,  Duke Realty
Investments,  Inc., an Indiana corporation,  authorized to do and doing business
in the State of  Missouri,  as  Landlord  (hereinafter  "Landlord")  and EXPRESS
SCRIPTS,  INC., a Delaware  corporation,  authorized to do and doing business in
the State of Missouri, as Tenant (hereinafter "Tenant").

                              W I T N E S S E T H:

     WHEREAS,  Landlord and Tenant  entered into a certain Office Lease dated as
of August 14, 1998 for all of the space in that certain  Building (as defined in
said  Office  Lease)  which  Landlord  is  in  the  process  of  causing  to  be
constructed,  which said Office  Lease was  heretofore  amended by that  certain
First Lease Amendment dated as of November 5, 1998 (the "First  Amendment") (the
said  Office  Lease  and the  First  Amendment  being  hereinafter  referred  to
collectively as the "Lease"); and

     WHEREAS,  Landlord  and  Tenant  desire to  further  amend the Lease in the
limited respects hereinafter set forth.

     NOW,  THEREFORE,  in  consideration  of the premises,  the mutual covenants
herein contained and each act performed  hereunder by the parties,  Landlord and
Tenant hereby agree as follows:

     1. Except as otherwise  herein  specifically  provided,  terms used in this
Second Lease Amendment shall have the meaning set forth in the Lease.

     2. At the  beginning of the second and third  paragraphs  of Section  3.11,
INSURANCE,  the word "Landlord"  shall be substituted for the word "Tenant".  In
the tenth (10th) line of the second  paragraph of Section 3.11,  INSURANCE,  the
word "Landlord" shall be substituted for the word "Tenant". The last sentence of
the  second  paragraph  of  Section  3.11,  INSURANCE,  shall be  deleted in its
entirety. At the end of the fourth paragraph of Section 3.11, INSURANCE,  before
the  period  the words  "and  Tenant"  shall be  added.  At the end of the fifth
paragraph of Section 3.11, INSURANCE, the word "Tenant" shall be substituted for
the word "Landlord".  At the beginning of the first and third lines of the sixth
paragraph of Section 3.11,  INSURANCE,  the word "Landlord" shall be substituted
for the word "Tenant".  At the end of Section 3.11, INSURANCE shall be added the
following:  "The reasonable cost of insurance required by the provisions of this
Section  3.11,  INSURANCE to be provided by Landlord  shall be paid by Tenant to
Landlord  within  thirty  (30) days of  receipt  by Tenant  of a  statement,  in
reasonable detail, as Additional Rent."

     3. This Second  Amendment shall be incorporated  into and made apart of the
Lease.  All  provisions  of the Lease not expressly  modified or amended  hereby
shall remain in full force and effect.

     IN WITNESS WHEREOF,  the parties have caused this Second Lease Amendment to
be executed as of the day and year first written above.

LANDLORD:                             DUKE REALTY LIMITED PARTNERSHIP,
                                      an Indiana limited partnership

                                      By:    DUKE REALTY INVESTMENTS, INC.
                                             an Indiana corporation,
(SEAL)                                       its general partner


                                             By: /s/ Gregory Thurman
ATTEST:                                      W. Gregory Thurman
                                             Vice President and General Manager,
/s/ James D. Echkoff                         St. Louis Office Group
James D. Eckhoff
Vice President 
and Corporate Attorney


TENANT:                                EXPRESS SCRIPTS, INC.,
                                       a Delaware corporation


(SEAL)                                  By:  /s/ Barrett Toan
                                             Barrett Toan, President

ATTEST:

/s/ Thomas M. Boudreau
Thomas M. Boudreau
Secretary


STATE OF MISSOURI   )
                    )  SS.
COUNTY OF ST. LOUIS )


     On this 12th day of February 1999, before me personally appeared W. GREGORY
THURMAN, to me personally known, who, being by me duly sworn, did say that he is
Vice  President  and General  Manager,  St.  Louis  Office  Group of DUKE REALTY
LIMITED PARTNERSHIP, an Indiana limited partnership, and general partner in DUKE
REALTY INVESTMENTS,  INC., an Indiana corporation,  and that the seal affixed to
the foregoing SECOND LEASE AMENDMENT is the corporate seal of said  corporation,
and that said  SECOND  LEASE  AMENDMENT  was signed and sealed on behalf of said
limited  partnership  and  said  corporation,  by  authority  of  its  Board  of
Directors,  and said W. GREGORY Thurman acknowledged said SECOND LEASE AMENDMENT
to be  the  free  act  and  deed  of  the  said  limited  partnership  and  said
corporation.

     IN WITNESS  WHEREOF,  I have  hereunto  set my hand and affixed my official
seal in the County and State aforesaid, the day and year first above written.


                                        /s/ Kathleen M. Wade
                                             Notary Public


STATE OF MISSOURI   )
                    ) SS.
COUNTY OF ST. LOUIS )


     On this 25th day of January  1999,  before me appeared  BARRETT TOAN, to me
personally  known, who, being by my duly sworn, did say that he is the President
of EXPRESS SCRIPTS,  INC., a corporation of the State of Delaware,  and that the
seal  affixed  to  the  foregoing  instrument  is the  corporate  seal  of  said
corporation,  and that said  instrument  was signed and sealed on behalf of said
corporation  by  authority  of its Board of  Directors;  and said  BARRETT  TOAN
acknowledged said instrument to be the free act and deed of said corporation.

     IN WITNESS  WHEREOF,  I have  hereunto  set my hand and affixed my official
seal in the County and State aforesaid, the day and year first above written.


                                             /s/ Kathleen M. Dolan
                                                 Notary Public





                                  Exhibit 21.1

SUBSIDIARY                         STATE OF INCORPORATION    D/B/A
- ----------                         ----------------------    -----
ESI Canada, Inc.                   New Brunswick, Canada     None
ESI Canada Holdings, Inc.          New Brunswick, Canada     None
Express Scripts Vision 
    Corporation                    Delaware                  ESI Vision Care
IVTx, Inc.                         Delaware                  None
ESI/VRx Sales Development Co.      Delaware                  None
Great Plains Reinsurance Company   Arizona                   None
Practice Patterns Science, Inc.    Delaware                  None
Managed Prescription 
    Network, Inc.                  Delaware                  Columbia Pharmacy
                                                                Solutions
Value Health, Inc.                 Delaware                  None
Health Care Services, Inc.         Pennsylvania              None
MHI, Inc.                          Nevada                    None
ValueRx, Inc.                      Delaware                  None
ValueRx of Michigan, Inc.          Michigan                  None
ValueRx Pharmacy Program, Inc.     Michigan                  None
ESI OnLine, Inc.                   Delaware                  None



                                  Exhibit 23.1


                       Consent of Independent Accountants

     We hereby  consent to the  incorporation  by reference in the  Registration
Statements  on  Form  S-8  (Nos.  333-72441,  333-69855,  333-48779,  333-48767,
333-48765,  333-27983,  333-04291,  33-64094,  33-64278,  33-93106)  of  Express
Scripts,  Inc. of our report dated  February  12, 1999,  appearing on page 38 of
this Form 10-K.


/s/ PricewaterhouseCoopers LLP
PricewaterhouseCoopers LLP
St. Louis, Missouri
March 25, 1999


<TABLE> <S> <C>

<ARTICLE> 5
       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                          DEC-31-1998
<PERIOD-END>                               DEC-31-1998
<CASH>                                         122,589
<SECURITIES>                                         0
<RECEIVABLES>                                  450,812
<ALLOWANCES>                                    17,806
<INVENTORY>                                     55,634
<CURRENT-ASSETS>                               656,907
<PP&E>                                          111909
<DEPRECIATION>                                   34410
<TOTAL-ASSETS>                                 1095461
<CURRENT-LIABILITIES>                           539296
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