EXPRESS SCRIPTS INC
SC 13D, 1999-10-22
SPECIALTY OUTPATIENT FACILITIES, NEC
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13D
                                 (Rule 13d-101)

                    INFORMATION TO BE INCLUDED IN STATEMENTS
                    FILED PURSUANT TO 13d-1(a) AND AMENDMENTS
                       THERETO FILED PURSUANT TO 13d-2(a)


                               PlanetRx.com, Inc.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)
                                   727049 10 8
- --------------------------------------------------------------------------------
                                 (CUSIP Number)

                            Thomas M. Boudreau, Esq.
                    Senior Vice President of Administration,
                          General Counsel and Secretary
                            c/o Express Scripts, Inc.
                              13900 Riverport Drive
                           Maryland Heights, MO 63043
                                 (314) 770-1666
- --------------------------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                 with copies to:

                           Michael J. McLaughlin, Esq.
                    Senior Vice President and General Counsel
                       c/o New York Life Insurance Company
                                51 Madison Avenue
                            New York, New York 10010
                                 (212) 576-4803


                                October 13, 1999
- --------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

     If the filing  person has  previously  filed a statement on Schedule 13G to
report the  acquisition  that is the subject of this Schedule 13D, and is filing
this  schedule  because  of Rule  13d-1(e),  13d-1(f)  or  13d-1(g),  check  the
following box:
                         (Continued on following pages)
                              (Page 1 of 28 Pages)

<PAGE>

 CUSIP No. 727049 10 8              Schedule 13D              Page 2 of 28 Pages


- --------------------------------------------------------------------------------
     1       NAMES OF REPORTING PERSONS
             I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

                        Express Scripts, Inc. 43-1420563
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP   (a)___
                                                                (b)___

- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
     3       SEC USE ONLY
- --------------------------------------------------------------------------------
     4       SOURCE OF FUNDS*
                                 OO (See Item 3)
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
     5       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED   ____
             PURSUANT TO ITEM 2(d) OR 2(e)
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
     6       CITIZENSHIP OR PLACE OF ORGANIZATION
                                    Delaware
- --------------------------------------------------------------------------------
   NUMBER OF SHARES       7     SOLE VOTING POWER

                                10,369,990 (See Item 5)
                        --------------------------------------------------------
BENEFICIALLY OWNED BY     8     SHARED VOTING POWER
                                        0
                        --------------------------------------------------------
    EACH REPORTING        9     SOLE DISPOSITIVE POWER
                                10,369,990 (See Item 5)
                        --------------------------------------------------------
     PERSON WITH          10    SHARED DISPOSITIVE POWER
                                        0
- --------------------------------------------------------------------------------
    11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                 10,369,990 shares of Common Stock (See Item 5)
- --------------------------------------------------------------------------------
    12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES      ____
             CERTAIN SHARES*
- --------------------------------------------------------------------------------
    13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                                    19.9%
- --------------------------------------------------------------------------------
    14       TYPE OF REPORTING PERSON*
                                       CO

- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>

 CUSIP No. 727049 10 8              Schedule 13D              Page 3 of 28 Pages

- --------------------------------------------------------------------------------
     1       NAMES OF REPORTING PERSONS
             I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

                        YourPharmacy.com, Inc. 43-1842584
- --------------------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP     (a)__
                                                                  (b)__
- --------------------------------------------------------------------------------
     3       SEC USE ONLY

- --------------------------------------------------------------------------------
     4       SOURCE OF FUNDS*
                                 OO (See Item 3)
- --------------------------------------------------------------------------------
     5       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED  ____
             PURSUANT TO ITEM 2(d) OR 2(e)
- --------------------------------------------------------------------------------
     6       CITIZENSHIP OR PLACE OF ORGANIZATION

                                    Delaware
- --------------------------------------------------------------------------------
   NUMBER OF SHARES       7     SOLE VOTING POWER

                                10,369,990 (See Item 5)
                        --------------------------------------------------------
BENEFICIALLY OWNED BY     8     SHARED VOTING POWER

                                          0
                        --------------------------------------------------------
    EACH REPORTING        9     SOLE DISPOSITIVE POWER

                                10,369,990 (See Item 5)
                        --------------------------------------------------------
     PERSON WITH          10    SHARED DISPOSITIVE POWER

                                          0
- --------------------------------------------------------------------------------
    11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                 10,369,990 shares of Common Stock (See Item 5)
- --------------------------------------------------------------------------------
    12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES   ____
             CERTAIN SHARES*
- --------------------------------------------------------------------------------
    13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                                      19.9%
- --------------------------------------------------------------------------------
    14       TYPE OF REPORTING PERSON*
                                       CO
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>

 CUSIP No. 727049 10 8              Schedule 13D              Page 4 of 28 Pages

- --------------------------------------------------------------------------------
     1       NAMES OF REPORTING PERSONS
             I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

                   New York Life Insurance Company 13-5582869

- --------------------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP    (a)___
                                                                 (b)___

- --------------------------------------------------------------------------------
     3       SEC USE ONLY

- --------------------------------------------------------------------------------
     4       SOURCE OF FUNDS*
                                 OO (See Item 3)

- --------------------------------------------------------------------------------
     5       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED   ____
             PURSUANT TO ITEM 2(d) OR 2(e)

- --------------------------------------------------------------------------------
     6       CITIZENSHIP OR PLACE OF ORGANIZATION

                                    New York
- --------------------------------------------------------------------------------
   NUMBER OF SHARES       7     SOLE VOTING POWER

                                10,369,990 (See Item 5)
                        --------------------------------------------------------
BENEFICIALLY OWNED BY     8     SHARED VOTING POWER

                                        0
                        --------------------------------------------------------
    EACH REPORTING        9     SOLE DISPOSITIVE POWER

                                10,369,990 (See Item 5)
                        --------------------------------------------------------
     PERSON WITH          10    SHARED DISPOSITIVE POWER

                                        0
- --------------------------------------------------------------------------------
    11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                 10,369,990 shares of Common Stock (See Item 5)

- --------------------------------------------------------------------------------
    12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES   ____
             CERTAIN SHARES*

- --------------------------------------------------------------------------------
    13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                                  19.9%
- --------------------------------------------------------------------------------
    14       TYPE OF REPORTING PERSON*
                                       IC

- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>

 CUSIP No. 727049 10 8              Schedule 13D              Page 5 of 31 Pages
- --------------------------------------------------------------------------------
     1       NAMES OF REPORTING PERSONS
             I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

                              NYLIFE LLC 13-4081725
- --------------------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP    (a)____
                                                                 (b)____

- --------------------------------------------------------------------------------
     3       SEC USE ONLY

- --------------------------------------------------------------------------------
     4       SOURCE OF FUNDS*
                                 OO (See Item 3)

- --------------------------------------------------------------------------------
     5       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED ___
             PURSUANT TO ITEM 2(d) OR 2(e)

- --------------------------------------------------------------------------------
     6       CITIZENSHIP OR PLACE OF ORGANIZATION

                                    Delaware
- --------------------------------------------------------------------------------
   NUMBER OF SHARES       7     SOLE VOTING POWER

                                10,369,990 (See Item 5)
                        --------------------------------------------------------
BENEFICIALLY OWNED BY     8     SHARED VOTING POWER

                                        0
                        --------------------------------------------------------
    EACH REPORTING        9     SOLE DISPOSITIVE POWER

                                10,369,990 (See Item 5)
                        --------------------------------------------------------
     PERSON WITH          10    SHARED DISPOSITIVE POWER

                                        0
- --------------------------------------------------------------------------------
    11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                 10,369,990 shares of Common Stock (See Item 5)
- --------------------------------------------------------------------------------
    12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES   ____
             CERTAIN SHARES*

- --------------------------------------------------------------------------------
    13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                                   19.9%
- --------------------------------------------------------------------------------
    14       TYPE OF REPORTING PERSON*
                                       OO

- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>

 CUSIP No. 727049 10 8              Schedule 13D              Page 6 of 28 Pages
- --------------------------------------------------------------------------------
     1       NAMES OF REPORTING PERSONS
             I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

                  NYLIFE HealthCare Management, Inc. 13-3155670
- --------------------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP      (a)___
                                                                   (b)___

- --------------------------------------------------------------------------------
     3       SEC USE ONLY

- --------------------------------------------------------------------------------
     4       SOURCE OF FUNDS*
                                 OO (See Item 3)
- --------------------------------------------------------------------------------
     5       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED    ____
             PURSUANT TO ITEM 2(d) OR 2(e)
- --------------------------------------------------------------------------------
     6       CITIZENSHIP OR PLACE OF ORGANIZATION

                                    Delaware
- --------------------------------------------------------------------------------
   NUMBER OF SHARES       7     SOLE VOTING POWER

                                10,369,990 (See Item 5)
                        --------------------------------------------------------
BENEFICIALLY OWNED BY     8     SHARED VOTING POWER

                                         0
                        --------------------------------------------------------
    EACH REPORTING        9     SOLE DISPOSITIVE POWER

                                10,369,990 (See Item 5)
                        --------------------------------------------------------
     PERSON WITH          10    SHARED DISPOSITIVE POWER

                                         0
- --------------------------------------------------------------------------------
    11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                 10,369,990 shares of Common Stock (See Item 5)

- --------------------------------------------------------------------------------
    12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES   ___
             CERTAIN SHARES*

- --------------------------------------------------------------------------------
    13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                                     19.9%
- --------------------------------------------------------------------------------
    14       TYPE OF REPORTING PERSON*
                                       CO

- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>

 CUSIP No. 727049 10 8              Schedule 13D              Page 7 of 28 Pages

     This  statement  is being  filed  while the  Reporting  Persons  are in the
process  of  verifying  information  required  herein  from  the  directors  and
executive  officers of the Reporting  Persons.  If the Reporting  Persons obtain
information  that  would  cause a change in the  information  contained  in this
statement on Schedule  13D, an amendment to this  statement  will be filed which
will set forth such change in information.

Item 1.       Security and Issuer

     This  Statement on Schedule 13D (the  "Schedule  13D") relates to shares of
Common Stock, par value $0.0001 per share (the "Shares"), of PlanetRx.com,  Inc.
("PlanetRx" or the "Company"),  a Delaware corporation.  The principal executive
offices of PlanetRx are located at 349 Oyster Point Blvd.,  Suite 201, South San
Francisco, CA 94080.

Item 2.       Identity and Background

                  (a)-(c),  (f) The name,  state of  incorporation  and business
address of the persons filing this statement (together, the "Reporting Persons")
are:

              (1) Express Scripts,  Inc., a Delaware  corporation  ("ESI") 13900
                  Riverport Drive, Maryland Heights, MO 63043, U.S.A.

              (2) YourPharmacy.com,  Inc., a Delaware  corporation ("YPC") 13900
                  Riverport Drive, Maryland Heights, MO 63043, U.S.A.

              (3) New York Life Insurance  Company,  a New York mutual insurance
                  company ("NYL") 51 Madison Avenue, New York, NY 10010, U.S.A.

              (4) NYLIFE LLC, a Delaware limited liability company ("NYLife") 51
                  Madison Avenue, New York, NY 10010, U.S.A.

              (5) NYLIFE  HealthCare  Management,  Inc., a Delaware  corporation
                  ("NYLIFE  HealthCare") 51 Madison Avenue,  New York, NY 10010,
                  U.S.A.

     ESI  is  headquartered  in  St.  Louis,   Missouri,   and  is  the  largest
full-service   pharmacy  benefit   management   (PBM)  company   independent  of
pharmaceutical manufacturer or drugstore ownership in North America. The Company
coordinates the distribution of outpatient pharmaceuticals through a combination
of benefit  management  services,  including  retail  drug card  programs,  mail
pharmacy services,  formulary  management programs and other clinical management
programs.  The Company provides these types of services for clients that include
health   maintenance   organizations   (HMOs),   health  insurers,   third-party
administrators, employers and union-sponsored benefit plans.

     The Company's PBM services are provided to approximately 36 million members
enrolled in health plans sponsored by the Company's  clients,  excluding members
from United  HealthCare  Group.  The Company  delivers its PBM services  through
networks  of more  than  52,000  retail  pharmacies,  representing  more than 99
percent of all U.S.  retail  pharmacies  and five  Company-owned  mail  pharmacy
service centers.

     YPC is a wholly owned subsidiary of ESI.

     NYL,  together  with  its  subsidiaries,  is one of the  largest  insurance
companies in the United States measured by assets.  NYL and its affiliates offer
life  insurance,   annuity,   and  securities  products  and  services  such  as
institutional  and retail  mutual funds and 401(k)  products,  and also provides
institutional asset management and trust services.  NYL is the parent of NYLife,
which is the parent of a number of non-insurance subsidiaries,  including NYLIFE
HealthCare,  which owns all the  outstanding  shares of class B common  stock of
ESI.  Holders of Class A common  stock of ESI are  entitled to one vote for each
share held by them on all matters  presented to stockholders.  Pursuant to ESI's
certificate of incorporation, the holders of class B common stock have ten votes
per share. As a result of the  disproporationate  voting rights given to holders
of Class B common  stock,  NYLIFE  HealthCare  owns  approximately  86.2% of the
combined  voting  power of ESI's  common  stock.  The  address of the  principal
business and the  principal  office of NYL,  NYLife and NYLIFE  HealthCare is 51
Madison Avenue, New York, New York 10010.

     Information  relating  to  the  directors  and  executive  officers  of the
Reporting Persons is contained in Appendix A attached hereto and is incorporated
herein by reference.

     (d) and (e)  None of the  Reporting  Persons,  nor,  to the  best of  their
knowledge,  any of the persons  listed in  Appendix A has,  during the last five
years, (i) been convicted in a criminal proceeding (excluding traffic violations
or  similar  misdemeanors)  or (ii)  been a party  to a  civil  proceeding  of a
judicial or administrative body of competent  jurisdiction which has resulted in
a judgment, decree or final order enjoining future violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Item 3.       Source and Amount of Funds or Other Consideration

     On October 13, 1999, YPC acquired the Shares of PlanetRx  described  herein
pursuant to the Asset  Contribution  and  Reorganization  Agreement  dated as of
August 31, 1999. A copy of the Asset Contribution and Reorganization  Agreement,
is attached hereto as Exhibit 1 to this Schedule 13D and is incorporated  herein
by  reference.  A  description  of the terms and  conditions of the agreement is
contained  in  Item 6  hereof,  which  description  is  incorporated  herein  by
reference.

Item 4.       Purpose of Transaction

     The Reporting  Persons  acquired the Shares for investment  purposes and as
part of the strategic  relationship  described in Item 6.  Depending  upon their
evaluation  of  the  Company's  business  and  prospects,  future  developments,
alternative  uses of  funds,  market  conditions  and  other  factors  that  the
Reporting  Persons may deem material to their respective  investment  decisions,
the Reporting Persons may purchase additional securities of PlanetRx in the open
market or in  private  transactions  or  otherwise,  or may  dispose of all or a
portion  of the  securities  of  PlanetRx  that  the  Reporting  Persons  own or
hereafter may acquire.  The Reporting  Persons reserve the right to exercise any
and  all of  their  respective  rights  and  privileges  as  securityholders  of
PlanetRx.  The Reporting  Persons,  however,  have no present plans or proposals
that would relate to or result in an extraordinary corporate transaction such as
a  merger,  reorganization  or  liquidation  involving  PlanetRx  or  any or its
subsidiaries  or a sale or other  transfer  of a  material  amount  of assets of
PlanetRx or any of its subsidiaries,  any material change in the  capitalization
or  dividend  policy of  PlanetRx  or any other  material  change in  PlanetRx's
corporate structure or business. However, pursuant to the Asset Contribution and
Reorganization Agreement, ESI is designated one member of the Board of Directors
of PlanetRx as long as ESI's  percentage  beneficial  ownership is not less than
5%, and has so designated Barrett Toan. See Item 6, which is incorporated herein
by reference.

Item 5.       Interest in Securities of the Issuer.

     (a) and (b). Under the definition of "beneficial ownership" as set forth in
Rule 13d-3 under the Securities Exchange Act of 1934, as amended,  the Reporting
Persons  currently have beneficial  ownership of 10,369,990  Shares of PlanetRx.
This amount constitutes  approximately  19.9% of the outstanding  Shares,  based
upon a total of  52,110,503  outstanding  Shares  as of  October  13,  1999,  as
represented by PlanetRx to the Reporting Persons on such date.

     The  Reporting  Persons  have the sole  power to vote and the sole power to
dispose such Shares,  provided that YPC has agreed not to sell or dispose of its
shares  without the prior  written  consent of Goldman  Sachs & Co. for 180 days
after October 7, 1999 (the "Lock-up Agreement"), as described in Item 6 below. A
copy of the Lock-up  Agreement  is filed as Exhibit 5 to this  Schedule  13D and
incorporated  herein by reference.  The filing of this Schedule 13D shall not be
construed as an admission that the Reporting Persons are the beneficial owner of
any Shares other than those discussed in this paragraph.

     (c)  Except as set forth in this Item 5 or Item 4, Item 6 or in  Appendix B
attached hereto and incorporated  herein by reference,  to the best knowledge of
the  Reporting  Persons,  neither the  Reporting  Persons nor any  directors  or
executive officers of any of the Reporting Persons and no other person described
in  Item  2  hereof  have,  beneficial  ownership  of,  or  has  engaged  in any
transaction during the past 60 days in, any Shares.

     (d) No one else will have the right to  receive  or the power to direct the
receipt of dividends from the Shares owned by the Reporting Persons.

     (e) Not applicable.

Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to
        Securities of the Issuer

     The Reporting Persons and, to the best knowledge of the Reporting  Persons,
the directors and executive officers of the Reporting  Persons,  do not have any
contract, arrangement,  understanding, or relationship (legal or otherwise) with
any person with respect to any securities of the Company other than as indicated
below and elsewhere herein.

      Asset Contribution and Reorganization Agreement and Other Agreements

     On October 13, 1999, ESI and YPC completed the transactions contemplated by
the Asset Contribution and Reorganization  Agreement dated as of August 31, 1999
(the   "Contribution   Agreement")   with  the  Company,   PRX  Holdings,   Inc.
("Holdings"),  and PRX Acquisition Corp.  ("Acquisition  Sub").  Pursuant to the
Contribution  Agreement,  YPC contributed  certain operating assets constituting
its e-commerce  business in prescription and  non-prescription  drugs and health
and beauty aids to Holdings in  exchange  for 19.9% of the  post-initial  public
offering (the "IPO") common equity of Holdings and the Company  assumed  certain
obligations of YPC. Simultaneously,  Acquisition Sub merged into the Company and
shareholders of the Company  received stock in Holdings,  which changed its name
to  "PlanetRx.com  Inc."  Additionally,  PlanetRx assumed options granted to YPC
employees  which  converted into options to purchase  approximately  1.8 million
shares of PlanetRx common stock.

     As a result of the transactions,  YPC became a 19.9% shareholder in the new
PlanetRx  (formerly  Holdings),  which  will  conduct  business  as an  internet
pharmacy.  PlanetRx filed a registration  statement on Form S-1, as amended (No.
333-82485),  relating to its IPO. A copy of the Contribution  Agreement is filed
as Exhibit 1 to this Schedule 13D and incorporated herein by reference.

     Also on August 31, 1999,  Express  Scripts  entered into an Agreement  with
PlanetRx  pursuant to which Express  Scripts has designated  PlanetRx as Express
Scripts'  exclusive  internet  pharmacy in the United  States for a term of five
years,  with a right to participate in the Express Scripts  pharmacy network for
ten years. Under the agreement,  customers who are covered under an ESI pharmacy
benefit plan will generally be able to fill  prescriptions at PlanetRx's website
and will be  entitled  to receive the  benefits  of the  coverage  under the ESI
pharmacy  benefit  plan.  The agreement  also provides for various  co-operative
marketing  activities  by  Express  Scripts  and  PlanetRx.   Pursuant  to  this
agreement,  PlanetRx will make certain payments to Express Scripts annually over
the term of the  agreement,  with a minimum  payment  obligation of  $11,650,000
annually  for  five  years,  plus  reimbursement  of  certain  expenses,  with a
potential  five  year  extension  (subject  to  certain  conditions),   plus  an
incremental fee based on ESI's members' activity on PlanetRx's website.  ESI has
committed  to  exclusively  co-brand  and  co-market  PlanetRx  as ESI's  online
pharmacy.  Co-branding  includes but is not limited to placing  PlanetRx's name,
logo and other  information  about  PlanetRx on ESI's  website and marketing and
sales materials.  Co-marketing  includes ESI promoting  PlanetRx as ESI's online
pharmacy in ESI's marketing and sales activities. The agreement became effective
on October  13,  1999.  PlanetRx  will also be included in the ESI network as an
authorized pharmacy for a minimum of ten years. The agreement contains customary
termination,  default and indemnification provisions. A copy of the Agreement is
filed as Exhibit 2 to this Schedule 13D and incorporated herein by reference.

     As  part  of the  relationship,  PlanetRx  agreed  to  certain  exclusivity
provisions that precludes it from directly or indirectly operating as a pharmacy
benefit manager.  PlanetRx also agreed to appoint a designee of ESI to its board
of directors  within five business  days after  October 13, 1999,  and agreed to
include the director  designated  by ESI in the group of nominees  that PlanetRx
recommends for election at each meeting of their stockholders to elect directors
as long as ESI's  percentage  beneficial  ownership is not less that 5%. ESI has
designated  Barrett A. Toan,  who became a director  of  PlanetRx on October 19,
1999. See Appendix A attached hereto for additional  information  concerning Mr.
Toan.

         Lock-up Agreement

     In  connection  with the IPO,  YPC agreed not to dispose of or hedge any of
its common stock or securities  convertible  into or exchangeable  for shares of
common stock for 180 days after  October 7, 1999,  except with the prior written
consent of Goldman,  Sachs & Co. Goldman,  Sachs & Co., however, may in its sole
discretion, at any time without notice, release all or any portion of the shares
subject to  lock-up  agreements.  A copy of the  Lock-up  Agreement  is filed as
Exhibit 5 to this Schedule 13D and incorporated herein by reference.

         Registration Rights Agreements

     Pursuant  to  the  Contribution  Agreement,  YPC  was  made a  party  to an
Investors Rights Agreement (the "Investors'  Rights Agreement") dated as of June
3, 1999 between  PlanetRx and certain  investors  of  PlanetRx.  The  Investors'
Rights Agreement,  as amended,  provides registration rights for certain holders
of common stock of PlanetRx,  including  YPC. The holders are entitled to demand
that  PlanetRx  register  their  shares  of  PlanetRx  common  stock  under  the
Securities Act of 1933, as amended (the "Securities Act"), at any time after six
months after October 7, 1999,  the effective  date of the IPO of PlanetRx,  upon
request from the holders of at least 30% of the  registrable  securities with an
anticipated  aggregate offering price of at least $7.5 million.  PlanetRx is not
required to effect more than two such demand registrations. If PlanetRx proposes
to register any of its securities  under the Securities  Act, either for its own
account or for the  account  of other  securityholders  exercising  registration
rights,  these holders are entitled to certain "piggyback"  registration rights,
i.e.,  notice of that PlanetRx is effecting a registration  under the Securities
Act and the right to include their shares therein, subject to certain conditions
and  limitations.  Further,  the holders may require PlanetRx to file additional
registration  statements  on Form S-3 upon  request from the holders of at least
30% of the  registrable  securities  and if the aggregate  offering  price is at
least $2.0 million.  All of these registration  rights are subject to conditions
and  limitations.  These  rights will not  terminate  with  respect to YPC until
October 13, 2004. In the event PlanetRx effects another public offering, YPC has
agreed  that it will  not  sell or  dispose  of any of its  Shares  for a period
specified  by the  managing  underwriter  (not to exceed 180 days),  without the
prior written  consent of such  underwriter,  subject to certain  conditions and
limitations.  A copy of the  Investors'  Rights  Agreement,  and  the  Amendment
thereto,  are filed as Exhibit 3 and Exhibit 4,  respectively,  to this Schedule
13D and incorporated herein by reference.

     PlanetRx also agreed to certain additional  registration  rights provisions
attached  as  Exhibit  B  to  the  Contribution  Agreement.  Pursuant  to  these
provisions,  PlanetRx  agreed,  as soon as practicable  after the closing of the
transactions  contemplated by the Contribution Agreement, to file a registration
statement  under the Securities  Act covering  one-half of the Shares and to use
its best  efforts  to cause it to become  effective  within  180 days after such
closing and to keep such registration  statement  effective until the earlier of
(x) two years after the closing,  (y) the sale of all the Shares  covered by the
registration statement, and (z) the date on which all the Shares held by YPC may
immediately  be sold under Rule 144 under the  Securities  Act during any 90-day
period.  The  obligations  of  PlanetRx  are subject to certain  conditions  and
limitations. PlanetRx has agreed to pay all expenses incurred in connection with
such  registration  (other than fees and  disbursements  of separate counsel for
YPC). A copy of the  registration  rights  provisions  are filed as Exhibit B to
Exhibit 1 to this Schedule 13D, and incorporated herein by reference.

                                    * * * * *

         The summary  contained in this  Schedule 13D of certain  provisions  of
such  agreements  are not  intended to be complete  and are  qualified  in their
entirety by reference to the full text of such  agreements,  copies of which are
incorporated  by  reference  as exhibits  hereto and  incorporated  by reference
herein.

Item 7.       Material To Be Filed As Exhibits
Exhibit 1       Asset Contribution and  Reorganization  Agreement dated August
                31, 1999 by and among  PlanetRx.com,  Inc., PRX Holdings,  Inc.,
                PRX  Acquisition,  Corp.,  YourPharmacy.com,  Inc.,  and Express
                Scripts, Inc.  (incorporated by reference to the Exhibit No. 2.1
                to  PlanetRx's  Registration  Statement  on Form S-1, as amended
                (Registration Number 333-82485)).

Exhibit 2       Agreement dated August 31, 1999 by and among Express Scripts,
                Inc. and PlanetRx.com, Inc. (incorporated by reference
                to the Exhibit No. 10.17 to PlanetRx's Registration Statement
                on Form S-1, as amended (Registration Number 333-82485)).

Exhibit 3       Amended and Restated  Investors'  Rights Agreement dated as of
                June 3, 1999,  (incorporated by reference to the Exhibit No. 4.2
                to  PlanetRx's  Registration  Statement  on Form S-1, as amended
                (Registration Number 333-82485)).

Exhibit 4       Amendment of Amended and Restated Investors' Rights Agreement
                dated as of October 13, 1999 by and between
                PlanetRx.com, Inc. and YourPharmacy.com, Inc.

Exhibit 5       Lock-up Agreement dated as of October 13, 1999 between
                YourPharmacy.com, Inc.and Goldman Sachs & Co.

Exhibit 6       Agreement Regarding Joint Filing and Power of Attorney


                                    SIGNATURE

     After  reasonable  inquiry and to the best of my  knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.

Dated:  October 21, 1999

                             EXPRESS SCRIPTS, INC.


                             By:                          *
                                 ------------------------------------------
                             Name:
                             Title:



                             YOURPHARMACY.COM, INC.


                             By:                          *
                                 ------------------------------------------
                             Name:
                             Title:



                              NEW YORK LIFE INSURANCE COMPANY


                              By:                          *
                                 ------------------------------------------
                              Name:
                              Title:



                              NYLIFE LLC


                              By:                          *
                                  ------------------------------------------
                              Name:
                              Title:


                              NYLIFE HEALTHCARE MANAGEMENT, INC.


                              By:                          *
                                  --------------------------------------------
                              Name:
                              Title:

By:      /s/ Keith J. Ebling
    --------------------------------
Name:    Keith J. Ebling
Title:   Authorized Agent and Attorney-in-Fact
         under Power of Attorney
         filed with this Schedule 13D
<PAGE>

                                   Appendix A

               INFORMATION CONCERNING THE DIRECTORS AND EXECUTIVE
                        OFFICERS OF THE REPORTING PERSONS

     Directors and Executive  Officers of Express Scripts,  Inc. Set forth below
are the name,  current business  address,  citizenship and the present principal
occupation  or  employment  of each  director and  executive  officer of Express
Scripts,  Inc.  The  principal  address of Express  Scripts,  Inc.  and,  unless
otherwise  indicated  below,  the current  business  address for each individual
listed below is 13900 Riverport Drive, Maryland Heights,  Missouri 63043, U.S.A.
Unless otherwise indicated,  each such person is a citizen of the United States.
Unless otherwise indicated,  each occupation set forth opposite the individual's
name refers to employment with Express Scripts, Inc.


Name and Current              Present Principal Occupation or Employment
Business Address

TERENCE D. ARNDT         Terrence  D.  Arndt serves as
                         Senior Vice  President of Marketing.

HOWRAD I. ATKINS         Howard I.  Atkins serves as a
                         director and the Executive  Vice  President  and
                         Chief   Financial Officer  of  NYL.

STUART L. BASCOMB        Stuart  L.  Bascomb serves as  Executive  Vice
                         President  of  Sales  and Provider  Relations.

THOMAS M. BOUDREAU       Thomas M.  Boudreau serves as  Senior Vice President,
                         General Counsel and Secretary.

JUDITH E. CAMPBELL       Judith E. Campbell serves as a director and as
                         Chief  Information Officer  of  NYL.

ROBERT W. DAVIS          Robert W.  Davis serves as Senior
                         Vice President and Chief Information Systems Officer.

MARK O.  JOHNSON         Mark O.  Johnson serves as Senior Vice  President of
                         Integration.

RICHARD M. KERNAN,JR.    Richard M.  Kernan serves as a director and as the
                         Executive Vice President and Chief Investment
                         Officer of NYL.

LINDA L.LOGSDON          Linda  L.  Logsdon serves as Executive Vice President
                         of Health Management  Services.

DAVID A. LOWENBERG       David A.  Lowenberg serves as Chief Operating Officer.

RICHARD A. NORLING       Richard A. Norling serves as a director of ESI and as
                         the Chief  Executive  Officer  of  Premier,  Inc.

GEORGE PAZ               George  Paz serves  as  Senior  Vice
                         President  and Chief  Financial  Officer.

JOSEPH W. PLUM           Joseph  W.  Plum serves as Vice  President  and Chief
                         Accounting  Officer.

NATHAN J. SCHULTZ        Nathan J.  Schultz serves as Senior Vice  President
                         of  Pharmaceutical  Manufacturer Relations.

FREDERICK J. SIEVERT     Frederick J. Sievert serves as a director and as
                         the  Vice  Chairman  of NYL.

STEPHEN N. STEINIG       Stephen N. Steinig serves as a director and as the
                         Senior Vice  President and Chief  Actuary of NYL.

SEYMOUR STERNBERG        Seymour  Sternberg serves as a director and as the
                         Chairman,  President and Chief Executive Officer of
                         NYL.

BARRETT A. TOAN          Barrett  A.  Toan serves as President, Chief Executive
                         Officer, and a director.

HOWARD L. WALTMAN        Howard L.  Waltman serves as Chairman of the Board and
                         is the retired Chairman and Chief Executive Officer of
                         Sanus Corp. Health Systems, which was a wholly-owned
                         subsidiary of NYL and subsequently sold to Aetna US
                         Healthcare, Inc.

NORMAN ZACHARY           Norman Zachary serves as a director and is the retired
                         President of Logica Data Architechts, Inc. a
                         consulting and software development company.
<PAGE>

     Directors and Executive  Officers of YourPharmacy.com,  Inc. Set forth
below  are the name,  current  business  address,  citizenship  and the  present
principal occupation or employment of each director and executive officer of
YourPharmacy.com,  Inc. The  principal  address of  YourPharmacy.com,  Inc. and,
unless  otherwise  indicated  below,  the  current  business  address  for  each
individual  listed below is 13900 Riverport Drive,  Maryland  Heights,  Missouri
63043, U.S.A. Unless otherwise  indicated,  each such person is a citizen of the
United States.  Unless otherwise  indicated,  each occupation set forth opposite
the individual's name refers to employment with YourPharmacy.com, Inc.

  Name and Current                  Present Principal Occupation or Employment
  Business Address

BARRETT A. TOAN                     Chairman and  President. See the description
                                    of Mr. Toan appearing above.

GEORGE PAZ                          Vice President.  See the description of
                                    Mr. Paz appearing above.

THOMAS M. BOUDREAU                  Vice President and Secretary. See the
                                    description of Mr. Boudreau appearing above.


     Directors and Executive  Officers of the New York Life  Insurance  Company.
Set forth below are the name,  current  business  address,  citizenship  and the
present  principal  occupation  or  employment  of each  director and  executive
officer of New York Life  Insurance  Company.  The principal  address of New
York Life Insurance  Company and, unless otherwise  indicated below, the current
business  address for each  individual  listed below is 51 Madison  Avenue,  New
York, New York 10010, U.S.A. Unless otherwise  indicated,  each such person is a
citizen of the United States.  Unless otherwise  indicated,  each occupation set
forth  opposite the  individual's  name refers to employment  with New York Life
Insurance Company.


Name and Current
Business Address                Present Principal Occupation or Employment

RAVI AKHOURY                       Ravi Akhoury serves as an Executive Vice
                                   President.  Mr. Akhoury is chairman and
                                   chief executive officer of MacKay Shields
                                   LLC.

BETTY C. ALEWINE                   Betty C. Alewine serves as a director.
Comstat Corporation                Ms. Alewine is president and chief
6560 Rock Spring Drive             executive officer of COMSAT Corporation.
Bethesda, MD 20817

HOWARD ATKINS                      Howard I. Atkins serves as Executive Vice
                                   President and the Chief Financial Officer.

ROBERT M. BAYLIS                   Robert M. Baylis serves as a director.
                                   Mr. Baylis is a former vice chairman of
                                   CS First Boston, Inc.

GARY G. BENANAV                    Gary G. Benanav serves as an Executive Vice
                                   President.  Mr. Benanav is chairman and
                                   chief executive officer of New York Life
                                   International, Inc.

JAMES L. BROADHEAD                 James L. Broadhead serves as a director.
FPL Group, Inc.                    Mr. Broadhead is chairman of the board,
700 Universe Boulevard             president and chief executive officer of FPL
(P.O. Box 14000)                   Group, Inc.
Juno Beach, FL 33408

WILLIAM G. BURNS                   William G. Burns serves as a director.
                                   Mr. Burns is a former vice chairman of
                                   NYNEX Corporation.

PATRICIA T. CARBINE                Patricia T. Carbine serves as a director.
                                   Ms. Carbine is a co-founder and
                                   president of the Ms. Foundation for
                                   Education and Communication, Inc.

JUDITH E. CAMPBELL                 Judith E. Campbell serves as Senior Vice
                                   President and the Chief Information Officer.

JESSIE M. COLGATE                  Jessie M. Colgate serves as Senior Vice
                                   President.

KENT B. FOSTER                     Kent B. Foster serves as a director and is
GTE Corporation                    is president of GTE Corporation.
600 Hidden Ridge - EO4G29
Irving, TX 75038

CONRAD K. HARPER                   Conrad K. Harper served as a director.
Simpson Thacher & Bartlett         Mr. Harper is a partner in the
425 Lexington Avenue               law firm of Simpson Thacher & Bartlett.
New York, NY 10017-3954



SOLOMAN GOLDFINGER                 Solomon Goldfinger serves as Senior Vice
                                   President.

PHILLIP J. HILDEBRAND              Phillip J. Hildebrand serves as Executive
                                   Vice President.

HARRY G. HOHN                      Harry G. Hohn serves as a director.
                                   Mr. Hohn is a retired chairman of the board
                                   and chief executive officer of New York
                                   Life.

RICHARD M. KERNAN, JR.             Richard M. Kernan serves as a
                                   director and is the Executive Vice
                                   President and Chief Investment Officer.

LESLIE G. MCCRAW, JR.              Leslie G. McCraw,Jr. serves as a director.
Fluor  Corporation                 Mr. McCraw is a retired  chairman  and
100 Fluor Daniel Drive             chief  executive  officer  of  Fluor
Greenville, SC 29607-2762          Corporation.

MICHAEL J. MCLAUGHLIN              Michael J. McLaughlin serves as Senior
                                   Vice President and General Counsel.

DAVIDW. MITCHELL                   David W. Mitchell serves as a director.
                                   Mr. Mitchell is  a  retired   chairman
                                   and  chief executive officer of Avon
                                   Products, Inc.

RICHARD R. PIVIROTTO               Richard R. Pivirotto serves as a director.
                                   Mr. Pivirotto is a retired chairman of
                                   Associated Dry Goods Corporation.

FREDERICK J. SIEVERT               Frederick J. Sievert serves as Vice Chairman
                                   of the Board.

SEYMOUR STERNBERG                  Seymour Sternberg serves as Chairman of the
                                   Board, President and Chief Executive Officer.

GEORGE J. TRAPP                    George J. Trapp serves as Executive Vice
                                   President and Secretary.

GARY E. WENDLANDT                  Gary E. Wendlandt serves as Executive Vice
                                   President.


     Directors and Executive Officers of the NYLIFE LLC. Set forth below are the
name, current business address, citizenship and the present principal occupation
or  employment  of each  director and  executive  officer of NYLIFE LLC. The
principal  address of NYLIFE LLC and, unless  otherwise  indicated  below,  the
current business address for each individual  listed below is 51 Madison Avenue,
New York, New York 10010, U.S.A. Unless otherwise indicated, each such person is
a citizen of the United States. Unless otherwise indicated,  each occupation set
forth opposite the individual's name refers to employment with NYLIFE LLC.

Name and Current
Business Address              Present Principal Occupation or Employment

RAVI AKHOURY             Ravi Akhoury serves as a Director.  See the description
                         of Mr. Akhoury above.

HOWARD I. ATKINS         Howard I. Atkins serves as a Director.  See the
                         description of Mr. Atkins above.

GARY G. BENANAV          Gary G. Benanav serves as a Director.  See the
                         description of Mr. Benanav above.

JUDITH E. CAMPBELL       Judith E. Campbell serves as a Director.  See the
                         description of Ms. Campbell above.

JESSIE M. COLGATE        Jessie M. Colgate serves as a Director.  See the
                         description of Ms. Colgate above.

THOMAS F.FLOURNOY,III    Thomas F. Flournoy, III serves as a Director and is a
                         consultant to NYL.

SOLOMON GOLDFINGER       Soloman Goldfinger serves as a Director.  See the
                         description of Mr. Goldfinger above.

PHILLIP J. HILDEBRAND    Phillip J. Hildebrand serves as a Director.  See the
                         description of Mr. Hildebrand above.

RICHARD M. KERNAN, JR.   Richard M. Kernan, Jr. serves as a Director.  See the
                         description of Mr. Kernan above.

MICHAEL J. MCLAUGHLIN    Michael J. McLaughlin serves as a Director.  See the
                         description of Mr. McLaughlin above.

FREDERICK J. SIEVERT     Frederick J. Sievert serves as a Director.  See the
                         description of Mr. Sievert above.

SEYMOUR STERNBERG        Seymour Sternberg serves as a Director and as
                         President.  See the description of Mr. Sternberg above.

GEORGE J. TRAPP          George J. Trapp serves as a Director.  See the
                         description of Mr. Trapp above.

JEAN E. HOYSTRADT        Jean E. Hoystradt serves as Senior Vice President,
                         Investments for NYL and NYLife.

MELBOURNE NUNES          Melbourne Nunes serves as Senior Vice President,  Legal
                         for NYL and NYLife.

ANNE F.  POLLACK         Anne F.  Pollack  serves  as  Senior  Vice
                         President, Individual Operations for NYL and NYLife.

STEPHEN C. ROUSSIN       Stephen C. Roussin serves as Senior Vice
                         President, Asset Management for NYL and NYLife.


     Directors and Executive Officers of the NYLIFE HealthCare Management,  Inc.
Set forth below are the name,  current  business  address,  citizenship  and the
present  principal  occupation  or  employment  of each  director and  executive
officer of NYLIFE  HealthCare  Management,  Inc.  The  principal  address of
NYLIFE HealthCare  Management,  Inc. and, unless otherwise  indicated below, the
current business address for each individual  listed below is 51 Madison Avenue,
New York, New York 10010, U.S.A. Unless otherwise indicated, each such person is
a citizen of the United States. Unless otherwise indicated,  each occupation set
forth opposite the individual's name refers to employment with NYLIFE HealthCare
Management, Inc.

Name and Current
Business Address                  Present Principal Occupation or Employment

HOWARD I. ATKINS             Howard  I.  Atkins  serves  as  Executive  Vice
                             President. See the description of Mr. Atkins above.

RICHARD M. KERNAN, JR.       Richard M. Kernan,  Jr. serves as a Director. See
                             the  description of Mr. Kernan above.

STEPHEN N. STEINIG           Stephen N.  Steinig  serves as  Executive  Vice
                             President.See the description of Mr. Steinig above.

SEYMOUR STERNBERG            Mr.Sternberg  serves as a Director and Chairman,
                             Chief Executive  Officer  and President.  See the
                             description of Mr. Sternberg above.

<PAGE>

                                   Appendix B

The  following  transactions  were  effected by MacKay  Shields LLC, an indirect
wholly-owned  investment  advisory subsidiary of New York Life Insurance Company
and a direct wholly-owned subsidiary of NYLIFE LLC, each of which is a Reporting
Person  described in Item 2 hereof,  during the past 60 days in shares of Common
Stock,  par  value  $0.0001  per  share,  of  PlanetRx.com,   Inc.,  a  Delaware
corporation ("PlanetRx"), for a third party managed account:

- --------------------------------------------------------------------------------
Date        Transaction            Number of Shares          Price Per Share
- --------------------------------------------------------------------------------

10/6/99      Purchase                10,000                      $16.0000
10/6/99      Purchase                   100                      $16.0000
10/7/99      Sale                     5,000                      $26.8750
10/8/99      Sale                     5,100                      $25.1875

All purchases were made directly from underwriters in PlanetRx's  initial public
offering and all sales were made through brokerage transactions on the NASDAQ.



                                    EXHIBIT 4
                                  AMENDMENT OF
                AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT



     THIS AMENDMENT OF AMENDED AND RESTATED  INVESTORS'  RIGHTS  AGREEMENT (this
"Amendment")  is made and entered  into as of October 13,  1999,  by and between
PlanetRx.com,  Inc., a Delaware  corporation (the "Company"),  YourPharmacy.com,
Inc., a Delaware  corporation  ("YPC"),  and the investors  listed on Schedule A
(the  "Investors")  to that  certain  Amended  and  Restated  Investors'  Rights
Agreement,  dated as of  September  3, 1999,  by and among the  Company  and the
Investors (the "Investors' Rights Agreement").

     WHEREAS,  the Company,  YPC PRX Holdings,  Inc., PRX Acquisition  Corp. and
Express  Scripts,  Inc.  have entered into that certain Asset  Contribution  and
Reorganization  Agreement  dated as of August 31, 1999 (the "Asset  Contribution
Agreement");

     WHEREAS,  pursuant to Section 4(h) of the Asset Contribution Agreement, the
Investors' Rights Agreement is to be amended to, among other things,  add YPC as
a party; and

     WHEREAS,  pursuant to section 3.7 of the Investors' Rights  Agreement,  the
Investors'  Rights  Agreement  may be amended  with the  written  consent of the
Company and the holders of a majority of the Registrable  Securities (as defined
in the Investors' Rights Agreement).

     NOW,  THEREFORE,  in consideration of the foregoing premises and the mutual
covenants  and  agreements  contained  herein  and for other  good and  valuable
consideration,  the receipt of which is hereby acknowledged,  the parties hereto
agree as follows:


     1.  Definitions.  Unless  otherwise  indicated,  words and terms  which are
defined in the Merger Agreement shall have the same meaning where used herein.


     2.  Addition  of YPC as a  Party.  YPC is  hereby  added  as a party to the
Investors' Rights Agreement,  including,  with out limitation, as a Holder under
Section 1.1(b) thereof, with all corresponding benefits and obligations, and the
Schedule  of  Investors,  attached  thereto  as  Exhibit  A, shall be amended to
include YPC.

     3.  Amendment to Section 1.4. The  introductory  language to Section 1.4 of
the Investors' Rights Agreement is hereby amended to read in its entirety:

     "1.4Form S-3  Registration.  In case the Company  shall receive from either
(i) the Holders of at least thirty percent (30%) of the  Registrable  Securities
or (ii) the Holders of  Registrable  Securities  with an  anticipated  aggregate
offering  price of at least  $2,000,000 a written  request or requests  that the
Company effect a registration on Form S-3 (or similar or successor form) and any
related  qualification  or  compliance  with  respect  to all  or a part  of the
Registrable Securities owned by such Holder or Holders, the Company shall:"

     4.  Amendment  to  Section  1.14.  Section  1.14 of the  Investors'  Rights
Agreement is hereby amended to read in  its entirety:

     "1.14  Termination of Registration  Rights.  No Holder shall be entitled to
exercise  any  right  provided  for in this  Section  1 after  three  (3)  years
following the  consummation of the Initial  Offering or, as to any Holder,  such
earlier time at which all  Registrable  Securities  held by such Holder (and any
affiliate  of the Holder with whom such Holder  must  aggregate  its sales under
Rule 144) can be sold in any three  (3)-month  period  without  registration  in
compliance  with Rule 144 of the Act.  Notwithstanding  the foregoing and solely
with respect to YourPharmacy.com,  Inc., the registration rights provided for in
this  Section  1  shall  not  terminate  until  five  (5)  years  following  the
consummation of the Initial Offering.

     5. Continued  Validity of Investors'  Rights  Agreement.  Except as amended
hereby,  the Investors' Rights Agreement shall continue in full force and effect
as originally constituted and is ratified and affirmed by the parties hereto.

     6. Governing Law. This Agreement  shall be governed by and construed  under
the laws of the State of California as applied to  agreements  among  California
residents entered into and to be performed entirely within California.

     7.   Counterparts.   This   Amendment  may  be  executed  in  two  or  more
counterparts,  each of  which  shall be  deemed  an  original,  but all of which
together shall constitute one and the same instrument.

     IN WITNESS WHEREOF, the parties have executed this Amendment as of the date
first above written.

                              COMPANY:

                              PLANETRX.COM, INC.



                              By:      /s/ William Razzouk
                              Name:    William Razzouk
                              Title:   Chief Executive Officer


                              YPC:

                              YOURPHARMACY.COM, INC.


                              By:      /s/ Barrett A. Toan
                              Name:    Barrett A. Toan
                              Title:   Chairman of the Board of Directors



                                    EXHIBIT 5

                               PlanetRx.com, Inc.
                                Lock-Up Agreement
                                October 13, 1999

Goldman, Sachs & Co.
BancBoston Robertson Stephens, Inc.
Hambrecht & Quist LLC
William Blair & Company
c/o Goldman, Sachs & Co.
85 Broad Street
New York, NY  10004

         Re:  PlanetRx.com, Inc. - Lock-Up Agreement

Ladies and Gentlemen:

         The  undersigned   understands  that  you,  as   representatives   (the
"Representatives"), propose to enter into an Underwriting Agreement on behalf of
the several  Underwriters  named in Schedule I to such agreement  (collectively,
the  "Underwriters"),  with  PlanetRx.com,  Inc.,  a Delaware  corporation  (the
"Company"),  providing for a public  offering of the Common Stock of the Company
(the "Shares") pursuant to a Registration Statement on Form S-1 to be filed with
the Securities and Exchange Commission (the "SEC").

         In consideration of the agreement by the Underwriters to offer and sell
the  Shares,  and of other  good and  valuable  consideration  the  receipt  and
sufficiency of which is hereby acknowledged, the undersigned agrees that, during
the period  beginning  from the date of the final U.S.  Prospectus  covering the
public  offering of the Shares and continuing to and including the date 180 days
after the date of such final Prospectus,  the undersigned will not offer,  sell,
contract to sell, pledge,  grant any option to purchase,  make any short sale or
otherwise  dispose of any shares of Common Stock of the Company,  or any options
or  warrants  to  purchase  any shares of Common  Stock of the  Company,  or any
securities  convertible  into,  exchangeable  for or that represent the right to
receive shares of Common Stock of the Company,  whether now owned or hereinafter
acquired,  owned directly by the undersigned  (including holding as a custodian)
or with respect to which the  undersigned  has beneficial  ownership  within the
rules and regulations of the SEC (collectively the "Undersigned's Shares").

         The  foregoing   restriction  is  expressly   agreed  to  preclude  the
undersigned from engaging in any hedging or other  transaction which is designed
to or reasonably  expected to lead to or result in a sale or  disposition of the
undersigned's  Shares even if such Shares would be disposed of by someone  other
than the  undersigned.  Such  prohibited  hedging  or other  transactions  would
include without limitation any short sale or any purchase,  sale or grant of any
right (including  without limitation any put or call option) with respect to any
of the  undersigned's  Shares or with  respect to any  security  that  includes,
relates to, or derives any significant part of its value from such Shares.

         Notwithstanding  the  foregoing,   the  undersigned  may  transfer  the
Undersigned's  Shares (i) as a bona fide gift or gifts,  provided that the donee
or donees thereof agree to be bound by the restrictions  set forth herein,  (ii)
to any trust for the  direct  or  indirect  benefit  of the  undersigned  or the
immediate  family of the  undersigned,  provided  that the  trustee of the trust
agrees to be bound by the  restrictions  set forth herein,  and provided further
that any such transfer shall not involve a disposition  for value, or (iii) with
the prior written consent of Goldman, Sachs & Co. on behalf of the Underwriters.
For  purposes  of this  Lock-Up  Agreement,  "immediate  family"  shall mean any
relationship by blood, marriage or adoption,  not more remote than first cousin.
In addition, notwithstanding the foregoing, if the undersigned is a corporation,
the   corporation  may  transfer  the  capital  stock  of  the  Company  to  any
wholly-owned subsidiary of such corporation; provided, however, that in any such
case,  it shall be a condition to the transfer  that the  transferee  execute an
agreement  stating that the  transferee  is  receiving  and holding such capital
stock subject to the  provisions of this Agreement and there shall be no further
transfer of such capital stock except in  accordance  with this  Agreement,  and
provided  further that any such  transfer  shall not involve a  disposition  for
value. The undersigned now has, and, except as contemplated by clause (i), (ii),
or (iii) above,  for the duration of this Lock-Up  Agreement will have, good and
marketable  title to the  Undersigned's  Shares,  free and  clear of all  liens,
encumbrances, and claims whatsoever. The undersigned also agrees and consents to
the entry of stop transfer  instructions  with the Company's  transfer agent and
registrar against the transfer of the Undersigned's  Shares except in compliance
with the foregoing restrictions.

         The undersigned  understands  that the Company and the Underwriters are
relying upon this Lock-Up  Agreement in proceeding  toward  consummation  of the
offering.  The undersigned  further  understands that this Lock-Up  Agreement is
irrevocable  and  shall  be  binding  upon  the   undersigned's   heirs,   legal
representatives, successors, and assigns.

                            Very truly yours,
                            YourPharmacy.com, Inc
                            Exact Name of Stockholder

                            /s/ Barrett A. Toan
                            Authorized Signature

                            Barrett A. Toan, Chairman of the Board
                            Name & Title


                                    EXHIBIT 6

                        Agreement Regarding Joint Filing
                                       and
                                Power of Attorney

         The undersigned, for good and valuable consideration, hereby agree that
they shall  jointly file an  acquisition  statement  under  Section 13(d) of the
Securities Exchange Act of 1934, as amended,  with respect to the acquisition by
the  undersigned  of shares of common  stock of  PlanetRx.com,  Inc., a Delaware
corporation, and that they shall cooperate with each other regarding the filing,
and when appropriate, amending of such acquisition statement.

         The undersigned  hereby appoint Thomas M. Boudreau and Keith J. Ebling,
and  each  of  them  (with  full  power  to  each  of  them  to act  alone),  as
attorneys-in-fact  and agents, in all capacities,  to execute,  on their behalf,
and to file with the appropriate issuers,  exchanges and regulatory authorities,
this Schedule 13D and any and all  amendments to this Schedule 13D and documents
relating thereto required to be filed under the Securities Exchange Act of 1934,
as  amended,  including  exhibits,   attachments  and  amendments  thereto.  The
undersigned  hereby grant to said  attorneys-in-fact  full authority to do every
act  necessary  to be done in order to  effectuate  the  same as  fully,  to all
intents and purposes,  as the undersigned could if personally  present,  thereby
ratifying all that said attorneys-in-fact and agents may lawfully do or cause to
be done by virtue hereof.  This power of attorney shall remain in full force and
effect until either revoked in writing by the undersigned.

         The  undersigned  hereby execute this Agreement  Regarding Joint Filing
and Power of Attorney as of this 21st day of October, 1999.

                              EXPRESS SCRIPTS, INC.


                              By:                 /s/ Barrett A. Toan
                                    ------------------------------------------
                              Name:    Barrett A. Toan
                              Title:   President and Chief Executive Officer

                              YOURPHARMACY.COM, INC.


                              By:      /s/ Barrett A. Toan
                              Name:    Barrett A. Toan
                              Title:   President and Chairman

                              NEW YORK LIFE INSURANCE COMPANY

                              By:   /s/ Howard Atkins
                              Name: Howard Atkins
                              Title: Executive Vice President and CFO


                              NYLIFE LLC


                              By:  /s/ Melbourne Nunes
                              Name:  Melbourne Nunes
                              Title: Senior Vice President-Legal


                              NYLIFE HEALTHCARE MANAGEMENT, INC.


                              By:  /s/ Howard Atkins

                              Name:  Howard Atkins
                              Title: Executive Vice President


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