EXPRESS SCRIPTS INC
10-K, 2000-03-29
SPECIALTY OUTPATIENT FACILITIES, NEC
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 10-K


   X      ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
          EXCHANGE ACT OF 1934 FOR THE FISCAL YEAR ENDED
          DECEMBER 31, 1999, OR

          TRANSITION  REPORT  PURSUANT TO SECTION 13 OR 15(d) OF THE  SECURITIES
          EXCHANGE ACT OF 1934 FOR THE TRANSITION  PERIOD FROM  ____________  TO
          _____________.


                         Commission File Number: 0-20199

                              EXPRESS SCRIPTS, INC.
             (Exact name of registrant as specified in its charter)

          Delaware                                          43-1420563
(State or other jurisdiction                (I.R.S. employer identification no.)
of incorporation or organization)

13900 Riverport Dr., Maryland Heights, Missouri                63043
(Address of principal executive offices)                     (Zip Code)

       Registrant's telephone number, including area code: (314) 770-1666

          Securities registered pursuant to Section 12(b) of the Act:

                                      None

           Securities registered pursuant to Section 12(g) of the Act:

                      Class A Common Stock, $0.01 par value
                                (Title of Class)

     Indicate  by check mark  whether the  registrant  (1) has filed all reports
required to be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of
1934  during  the  preceding  12 months  (or for such  shorter  period  that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days. Yes X No ___

     Indicate by check mark if disclosure of delinquent  filers pursuant to Item
405 of Regulation of S-K is not contained herein, and will not be contained,  to
the  best  of  Registrant's   knowledge,  in  definitive  proxy  or  information
statements  incorporated  by  reference  in Part  III of this  Form  10-K or any
amendment to this Form 10-K. [X]

     The  aggregate   market  value  of   Registrant's   voting  stock  held  by
non-affiliates as of February 29, 2000, was  $1,075,723,976  based on 23,354,841
such shares held on such date by non-affiliates  and the last sale price for the
Class A Common  Stock on such date of $46.06 as reported on the Nasdaq  National
Market. Solely for purposes of this computation, the Registrant has assumed that
all directors and executive  officers of the  Registrant  and NYLIFE  HealthCare
Management, Inc. are affiliates of the Registrant.

Common stock outstanding as of February 29, 2000:   23,416,226  Shares Class A
                                                    15,020,000  Shares Class B

                       DOCUMENTS INCORPORATED BY REFERENCE

     Part  III  incorporates  by  reference  portions  of the  definitive  proxy
statement for the  Registrant's  2000 Annual Meeting of  Stockholders,  which is
expected to be filed with the Securities and Exchange  Commission not later than
120  days  after  the   registrant's   fiscal  year  ended  December  31,  1999.

         Information  that we have included or incorporated by reference in this
Annual Report on Form 10-K, and  information  that may be contained in our other
filings with the  Securities and Exchange  Commission  (the "SEC") and our press
releases or other  public  statements,  contain or may  contain  forward-looking
statements.  Please refer to a discussion of our forward looking  statements and
associated risks in "Item 1 --Forward  Looking  Statements and Associated Risks"
in this Annual Report on Form 10-K.


                                     PART I
                                   THE COMPANY

Item 1 - Business

Industry Overview

     Prescription  drug costs are the fastest  growing  component of health care
costs in the  United  States.  The U.S.  Health  Care  Financing  Administration
("HCFA")  estimates that prescription  drugs accounted for approximately 7.9% of
U.S. health care  expenditures in 1998, and are expected to increase to 11.2% by
2008. U.S.  prescription drug sales for 1998 were  approximately  $90.6 billion,
and HCFA projects  continued sales increases at an average annual growth rate of
approximately  10.6% through 2008,  compared to an average annual growth rate of
approximately  6.5% for total  health  care costs  during this  period.  Factors
underlying this trend include:

     o    increases   in  research   and   development   expenditures   by  drug
          manufacturers,  resulting in many new drug  introductions

     o    a shorter U.S.  Food and Drug  Administration  approval  cycle for new
          pharmaceuticals

     o    high  prices  for new  "blockbuster"  drugs

     o    an aging population

     o    increased  demand  for  prescription  drugs due to  increased  disease
          awareness by patients,  effective  direct-to-consumer  advertising  by
          drug  manufacturers  and a growing  reliance on  medication in lieu of
          lifestyle changes

     This trend creates a significant  challenge to HMOs,  health employers and
unions  that want to provide a drug  benefit  as part of the  health  plans they
offer to  members  of  their  respective  organizations.  These  health  benefit
providers,  or  "payors",  engage the  services of pharmacy  benefit  management
("PBM") companies to help them provide a cost-effective  drug benefit as part of
their  health  plan and to better  understand  the impact of  prescription  drug
utilization on their overall health care expenditures.

     In general, PBMs coordinate the distribution of outpatient  pharmaceuticals
through a combination of benefit-management services, including retail drug card
programs, mail pharmacy services and formulary management programs. PBMs emerged
during the late 1980s by combining  traditional  pharmacy claims  processing and
mail pharmacy services to create an integrated  product offering that could help
manage the  prescription  drug  benefit  for  payors.  During  the early  1990s,
numerous  PBMs were  created,  with some  providers  offering  a  comprehensive,
integrated  package of  services.  Currently,  there are an  estimated  100 PBMs
serving a  population  of  approximately  190  million  members  and  processing
approximately  2 billion  prescriptions  annually.  The PBM  industry  processed
approximately  $83 billion worth of prescriptions in 1999. The four largest PBMs
account for approximately 80% of prescription volume or member lives.

     The  services  offered by the more  sophisticated  PBMs have  broadened  to
include disease management  programs,  compliance  programs,  outcomes research,
drug therapy management programs and sophisticated data analysis.  Because these
advanced  capabilities  require resources that may not be available to all PBMs,
consolidation  in the  industry  has  occurred  in recent  years as PBMs seek to
increase scale and capability by merging with or purchasing other PBMs.

Company Overview

     We are the third largest PBM in North America and the largest  full-service
PBM independent of pharmaceutical  manufacturer or drug store ownership in North
America.  We believe  independence from  pharmaceutical  manufacturer  ownership
allows us to make unbiased formulary  recommendations to our clients,  balancing
both  clinical  efficacy and cost.  We also believe our  independence  from drug
store   ownership   allows  us  to  construct  a  variety  of   convenient   and
cost-effective  retail pharmacy  networks for our clients,  without favoring any
particular pharmacy chain.

     We provide a combination of benefit management  services,  including retail
drug card programs,  mail pharmacy services,  drug formulary management programs
and other  clinical  management  programs for  approximately  9,300 clients that
include  HMOs,  health  insurers,  third-party  administrators,   employers  and
union-sponsored  benefit  plans.  As of  January 1,  2000,  some of our  largest
clients include United HealthCare  Corporation  ("UHC"),  Aetna U.S. Healthcare,
Oxford Health  Plans,  Blue Cross Blue Shield of  Massachusetts,  Blue Shield of
California and the State of New York Empire Plan Prescription Drug Program.

     As of January 1, 2000, our PBM services were provided to approximately 38.5
million members, excluding approximately 9.5 million members associated with UHC
health plans who will be  transitioning  to another  provider  beginning June 1,
2000,  in the  United  States  and  Canada  who were  enrolled  in health  plans
sponsored by our clients.  Although  membership  counts are based on eligibility
data,   they   necessarily   involve   some   estimates,    extrapolations   and
approximations.  For example,  some plan designs allow for family coverage under
one  identification  number, and we make assumptions about the average number of
persons  per  family  in  calculating  our  total   membership.   Because  these
assumptions  may vary  between  PBMs,  membership  counts may not be  comparable
between  our  competitors  and us.  However,  we believe  our  membership  count
provides a reasonable  estimation of the population we serve, and can be used as
one measure of our growth.

     Our PBM offerings include:

     o    network  claims  processing,  mail pharmacy  services,  benefit design
          consultation,  drug utilization review, formulary management programs,
          disease  management and medical and drug data analysis  services,  and
          compliance  and therapy  management  programs for our clients

     o    market research  programs for  pharmaceutical  manufacturers

     o    medical  information   management  services,   which  include  outcome
          assessments,  the  development of data  warehouses  combining  medical
          claims  and  prescription  drug  claims,  and  sophisticated  decision
          support tools to evaluate disease  specific  interventions on cost and
          quality,   through  our  wholly-owned   subsidiary  Practice  Patterns
          Science,  Inc. ("PPS")

     o    informed  decision  counseling  services  through our  Express  Health
          LineSM division

     Our non-PBM offerings include:

     o    infusion therapy services through our wholly owned subsidiary, Express
          Scripts Infusion Services

     o    distribution  of   pharmaceuticals   requiring   special  handling  or
          packaging through our Express Scripts Specialty  Distribution Services
          subsidiary

     Our  revenues are  primarily  generated  from the delivery of  prescription
drugs  through  our  contractual  network of retail  pharmacies,  mail  pharmacy
services and infusion therapy  services.  In 1999, 1998 and 1997,  revenues from
the delivery of prescription  drugs to our members  represented 93.4%, 98.2% and
97.3%, respectively,  of our total revenues. Revenues from services, such as the
administration of contracts between our clients and the clients' retail pharmacy
networks  (the "Net  Basis"),  market  research  programs,  the sale of  medical
information  management  services,  the  sale of  informed  decision  counseling
services and our Specialty  Distribution Services comprised the remainder of our
revenues.

     Our PBM  services  are  delivered  primarily  through  networks  of  retail
pharmacies  that are under  non-exclusive  contract  with us,  through five mail
pharmacy service centers,  which we own and operate,  and through  PlanetRx.com,
Inc. ("PlanetRx"). Our largest retail pharmacy network includes more than 53,000
retail  pharmacies,  representing  more than 99% of all retail pharmacies in the
United  States.  In 1999,  we  processed  approximately  211.8  million  network
pharmacy claims and 10.6 million mail pharmacy prescriptions,  with an estimated
total drug spending of $8.7 billion,  excluding UHC network  pharmacy  claims of
62.1 million having an estimating total drug spending of $2.4 billion.

     During the fourth quarter of 1999, we transferred  substantially all of the
assets of YourPharmacy.com, Inc., our wholly-owned Internet pharmacy subsidiary,
to PlanetRx in exchange for approximately 19.9% of PlanetRx's outstanding common
stock. In conjunction  with the transfer,  we entered into a pharmacy  agreement
pursuant to which PlanetRx will be our exclusive Internet pharmacy in the United
States for a term of 5 years,  with the right to  participate in our network for
10 years.

     We were incorporated in Missouri in September 1986, and were reincorporated
in Delaware in March 1992. We have two classes of common  stock,  Class A Common
Stock  and  Class B Common  Stock.  Each  share of the  Class B Common  Stock is
entitled to ten votes, and each share of the Class A Common Stock is entitled to
one vote. All of the issued and  outstanding  shares of the Class B Common Stock
are owned by NYLIFE HealthCare.  Our principal  executive offices are located at
13900 Riverport Drive, Maryland Heights, Missouri 63043. Our telephone number is
(314) 770-1666.

Products and Services

Pharmacy Benefit Management

     Overview.   Our  PBM  services   involve  the   management   of  outpatient
prescription  drug usage to foster high quality,  cost-effective  pharmaceutical
care through the application of managed care principles and advanced information
technologies.  We offer our PBM services to our clients in the United States and
Canada. Our PBM offerings include:

     o    retail  pharmacy  network  administration

     o    mail pharmacy services

     o    benefit  plan  design   consultation

     o    formulary  administration

     o    electronic point-of-sale claims processing

     o    drug  utilization  review

     o    the  development  of advanced  formulary  compliance  and  therapeutic
          intervention  programs

     o    therapy  management  services  such as  prior  authorization,  therapy
          guidelines,   step  therapy   protocols   and   formulary   management
          interventions

     o    sophisticated management information reporting and analytic services

     o    outcomes  assessments,  the development of data  warehouses  combining
          medical  claims  and  prescription  drug  claims,   and  sophisticated
          decision support tools to evaluate  disease specific  interventions on
          cost and quality

     o    informed   decision   counseling

     o    drug information through our DrugDigest.org website

     During 1999, 98.5% of our revenues were derived from PBM services, compared
to 97.9% and 96.8%  during  1998 and 1997,  respectively.  The  number of retail
pharmacy network claims processed and mail pharmacy claims processed,  including
UHC, has increased to 273.9 million and 10.6 million  claims,  respectively,  in
1999, from 42.9 million and 2.1 million claims,  respectively,  in 1995.  During
1998 and 1997,  we  processed  113.2  million and 73.2 million  retail  pharmacy
network  claims,  respectively,  and 7.4 million and 3.9 million  mail  pharmacy
claims, respectively.

     Retail Pharmacy Network Administration.  We contract with retail pharmacies
to provide  prescription  drugs to members of the pharmacy benefit plans managed
by us. In the United States,  these pharmacies  typically  discount the price at
which they will provide drugs to members in return for  designation as a network
pharmacy.  We manage  three  nationwide  networks  in the United  States and one
nationwide network in Canada that are responsive to client  preferences  related
to cost  containment and convenience of access for members.  We also manage over
300 networks of pharmacies  that we have designed to meet the specific  needs of
some of our larger  clients or that are under direct  contract  with our managed
care clients.

     All retail pharmacies in our pharmacy networks  communicate with us on-line
and in real time to process  prescription  drug claims.  When a member of a plan
presents  his or her  identification  card at a network  pharmacy,  the  network
pharmacist sends the specified claim data in an industry-standard format through
our  systems,  which  process the claim and respond to the  pharmacy,  typically
within one or two seconds. The electronic processing of the claim involves:

     o    confirming the member's  eligibility for benefits under the applicable
          health  benefit plan and the conditions to or limitations of coverage,
          such as the amount of copayments or deductibles  the member must pay

     o    performing a concurrent drug  utilization  review ("DUR") analysis and
          alerting the pharmacist to possible drug interactions and reactions or
          other indications of inappropriate  prescription drug usage

     o    updating the member's prescription drug claim record

     o    if the claim is  accepted,  confirming  to the  pharmacy  that it will
          receive payment for the drug dispensed

     Mail  Pharmacy.  We integrate  our retail  pharmacy  services with our mail
pharmacy services. We operate five mail pharmacies, located in Maryland Heights,
Missouri; Tempe, Arizona; Albuquerque, New Mexico; Bensalem,  Pennsylvania;  and
Troy, New York.  These  pharmacies  provide  members with  convenient  access to
maintenance  medications  and enable our  clients  and us to control  drug costs
through operating efficiencies and economies of scale. In addition,  through our
mail  service  pharmacies,  we are directly  involved  with the  prescriber  and
member,   and  are  generally   able  to  achieve  a  higher  level  of  generic
substitutions  and therapeutic  interventions  than can be achieved  through the
retail pharmacy networks. This further reduces our clients' costs.

     Internet  Pharmacy.  In October  1999,  we entered into an  agreement  with
PlanetRx whereby PlanetRx became our exclusive  Internet  pharmacy in the United
States for a term of five years,  with a right to  participate  in our  pharmacy
network for ten years.

     Benefit Plan Design and Consultation.  We offer  consultation and financial
modeling to assist the client in  selecting a benefit plan design that meets its
needs for member  satisfaction and cost control.  The most common benefit design
options we offer to our clients are:

     o    financial  incentives  and  reimbursement  limitations  on  the  drugs
          covered  by the  plan,  including  drug  formularies,  flat  dollar or
          percentage of  prescription  cost  copayments,  deductibles  or annual
          benefit maximum

     o    generic drug substitution incentives

     o    incentives or requirements to use only network  pharmacies or to order
          certain drugs only by mail

     o    reimbursement limitations on the number of days' supply of a drug that
          can be obtained

     The  selected  benefit  design  is  entered  into  our  electronic   claims
processing  system,  which  applies  the plan  design  parameters  as claims are
submitted and enables our clients and us to monitor the financial performance of
the plan.

     Formulary Development,  Compliance and Therapy Management.  Formularies are
lists of drugs for which coverage is provided under the  applicable  plan.  They
are widely used in managed health care plans and, increasingly,  by other health
plan managers.  We have over 10 years of formulary  development expertise and an
extensive clinical pharmacy department.

     The foremost  consideration  in the  formulary  development  process is the
clinical  appropriateness  of the drug,  not the cost of the drug. In developing
formularies,  we first  make a  rigorous  therapeutic  assessment  of the drug's
clinical  effectiveness.  After  the  clinical  recommendation  is  made,  it is
evaluated  on an economic  basis.  No drug is added to the  formulary  until our
National Pharmacy & Therapeutics Committee, a panel of 17 independent physicians
and 4 of our  pharmacists,  approves  it.  This  panel  does  not  consider  any
information  regarding the discount/rebate  arrangement that might be negotiated
with the manufacturer.

     Once a client  selects and adopts a formulary,  we administer the formulary
through a variety of mechanisms. We administer a number of different formularies
for our clients that often identify  preferred  drugs whose use is encouraged or
required  through various benefit design  features.  Historically,  many clients
have selected a plan design that  includes an open  formulary in which all drugs
are covered by the plan and  preferred  drugs,  if any, are merely  recommended.
More  advanced  options  consist of  restricted  formularies,  in which  various
financial or other  incentives  exist for the selection of preferred  drugs over
their non-preferred  counterparts,  or closed formularies, in which benefits are
available only for drugs listed on the formulary.  Formulary  preferences can be
encouraged:

     o    by restricting  the formulary  through plan design  features,  such as
          tiered copayments, which require the member to pay a higher amount for
          a non-preferred drug

     o    through prescriber education programs, in which we or the managed care
          client  actively seek to educate the  prescribers  about the formulary
          preferences

     o    through our drug choice  management  program,  which actively promotes
          therapeutic and generic interchanges to reduce drug costs

     We also provide formulary  compliance services to our clients. For example,
if the doctor has not prescribed the preferred  drug on a client  formulary,  we
notify the pharmacist through our claims processing system. The pharmacist or we
can then contact the doctor to attempt to obtain the doctor's  consent to switch
the  prescription  to the preferred  product.  The doctor has the final decision
making  authority in prescribing  the  medication.  The doctor will consider the
substitution  in  light  of the  patient's  medical  history,  and  writes a new
prescription or denies the substitution.

     We also offer innovative  proprietary drug utilization  review and clinical
intervention  programs,  to  assist  clients  in  managing  compliance  with the
prescribed drug therapy and inappropriate prescribing practices.

     Although we derive substantial revenue from  pharmaceutical  manufacturers,
we recognize our primary  responsibility is to the plan sponsors, and we believe
our contracts with the pharmaceutical  manufacturers  provide us the flexibility
to utilize  the most  efficacious  products.  We  contract  with  pharmaceutical
manufacturers  only after our National  Pharmacy and Therapeutics  Committee has
performed its evaluation.

     Information Reporting and Analysis and Disease Management Programs. Through
the  development  of  increasingly   sophisticated  management  information  and
reporting  systems,  we  believe  we  manage  prescription  drug  benefits  more
effectively.  We have  developed  various  services  to offer our  clients.  One
service  enables a client to analyze  prescription  drug data to  identify  cost
trends and budget for expected  drug costs,  to assess the  financial  impact of
plan design  changes  and to identify  costly  utilization  patterns  through an
on-line prescription drug decision support tool called InformRxTM.  This service
permits  our  clients'  medically  sophisticated  personnel,  such as a clinical
pharmacist employed by an HMO, to analyze prescription drug data on-line.

     In  addition,  our PPS  subsidiary  builds  sophisticated  data  warehouses
combining medical claims, prescription drug claims, and clinical laboratory data
to provide  decision  support  to the  health  care  industry.  Proprietary  PPS
applications  enable  users to quickly  evaluate  shifts in  medical  conditions
afflicting  membership and the  effectiveness of  interventions  from a cost and
quality  of  care  perspective.  PPS  users  can  evaluate  the  impact  of  new
prescription  drugs  on the  cost  and  results  of  treating  specific  medical
conditions.  Working with leading  health care  organizations,  PPS continues to
push the  sophistication  of data  warehouse  and the  applications  to  provide
insight into the subtleties of health care delivery.

     We offer  additional  disease  management and education  programs to assist
health  benefit  plans and our members in managing  the total  health care costs
associated with certain diseases,  such as asthma,  diabetes and  cardiovascular
disease.  These  programs  are based upon the premise  that patient and provider
behavior can positively  influence  medical  outcomes and reduce overall medical
costs.  Patient  identification can be accomplished through claims data analysis
or  self-enrollment.  Risk  stratification  surveys are conducted to establish a
plan of care for individual program participants. Patient education is primarily
effected  through a series of telephone and written  communications  with nurses
and  pharmacists,  and both providers and patients receive progress reports on a
regular basis. Outcome surveys are conducted and results are compiled to analyze
the clinical, personal and economic impact of the program.

     Electronic  Claims  Processing  System.  Our electronic  claims  processing
system enables us to implement sophisticated  intervention programs to assist in
managing  prescription  drug  utilization.  The  system can be used to alert the
pharmacist to generic  substitution and therapeutic  intervention  opportunities
and formulary  compliance  issues,  or to  administer  prior  authorization  and
step-therapy  protocol programs at the time a claim is submitted for processing.
Our  claims  processing  system  also  creates a  database  of drug  utilization
information  that can be accessed both at the time the prescription is dispensed
and also on a retrospective  basis to analyze utilization trends and prescribing
patterns for more intensive management of the drug benefit.

     Informed  Decision  Counseling.  We offer health care  decision  counseling
services  through our Express  Health  LineSM  division.  This service  allows a
member to call a  toll-free  telephone  number and  discuss a health care matter
with a care counselor who utilizes on-line decision support  protocols and other
guidelines  to provide  information  to assist the member in making an  informed
decision in seeking appropriate  treatment.  Records of each call are maintained
on-line for future  reference.  The service is  available  24 hours a day.  Some
multilingual  capabilities  and  service  for  the  hearing  impaired  are  also
available.  The counselors  provide follow-up service to members to determine if
their  situation  was  resolved  or if  the  counselor  may  provide  additional
assistance.  Member satisfaction and outcomes  assessments are tracked through a
combination of member surveys, a quality assurance plan and system reports.

     Consumer  Health and  Medical  Information.  In July 1999,  we  launched an
Internet   site,   DrugDigest.org,   to  provide  a   comprehensive   source  of
non-commercial,   fact-based  health  and  medical  information.  DrugDigest.org
enables a consumer to stay  informed  about the wide variety of medicines on the
market  today,  understand  their  treatment  options and take an active role in
their  healthcare.  These  services are offered  through  reference  material on
drugs,  vitamins,  medical research and disease  management,  discussion groups,
"Ask the pharmacist"  feature,  and an e-Letter  program  enabling  consumers to
register and receive news and research on medical  conditions  most important to
them.

Non-PBM

     In addition to PBM services,  we also provide  non-PBM  services  including
outpatient infusion therapy, and specialty  distribution to our clients.  During
1999, 1.5% of our revenues were derived from non-PBM services,  compared to 2.1%
and 3.2% during 1998 and 1997,  respectively.  This decline is partially  due to
the  acquisitions  of ValueRx and DPS,  which  significantly  increased  our PBM
service revenues.

     Express Scripts  Infusion  Services.  We provide  infusion therapy services
which involve the  administration of prescription  drugs and other products to a
patient by  catheter,  feeding tube or  intravenously,  through our wholly owned
subsidiary,  IVTx,  Inc.,  operating  under the name  Express  Scripts  Infusion
Services.  Infusion Services' clients, which include managed care organizations,
third-party  administrators,  insurance  companies,  case management  companies,
unions and  self-insured  employers,  benefit from outpatient  infusion  therapy
services  because  the length of  hospital  stays can be  reduced.  Rather  than
receiving  infusion therapy in a hospital,  Infusion  Services provides infusion
therapy  services  to  patients  at  home,  in  a  physician's  office  or  in a
free-standing  center  operated by a managed care  organization or other entity.
Infusion   Services   provides   antimicrobial,   cardiovascular,   hematologic,
nutritional, analgesic, chemotherapeutic,  hydration, endocrine, respiratory and
AIDS management treatments to patients. Infusion Services generally prepares the
treatments  in  one of its  infusion  therapy  pharmacies,  which  are  licensed
independently  of our mail  pharmacies.  The treatments are either  administered
under the  supervision  of  Infusion  Services'  staff of  registered  nurses or
licensed  vocational  nurses who are  employed at one of the  Infusion  Services
sites or, in areas where  Infusion  Services  does not have a facility,  through
contracted registered nurses employed or otherwise retained by nursing agencies.
Infusion  Services may also contract for pharmacy services for patients who live
in outlying areas.

     We have facilities  supporting our infusion services operations in Houston,
Texas; Dallas, Texas; Columbia,  Maryland; Maryland Heights, Missouri; Columbia,
Missouri;  Springfield,  New Jersey;  and West Chester,  Pennsylvania.  Infusion
Services'  information system maintains patient profiles and documents doses and
supplies  dispensed,  and its drug  utilization  review  component  accesses our
prescription records for members receiving both infusion and oral drug therapies
to screen for drug interactions, incompatibilities and allergies.

     Express  Scripts  Specialty  Distribution  Services.  We provide  specialty
distribution  services  by  assisting  pharmaceutical   manufacturers  with  the
distribution  of,  and  creation  of a database  of  information  for,  products
requiring  special   handling/packaging  or  products  targeted  to  a  specific
physician or patient  population  or to indigent  patients.  These  services are
provided in our Tempe,  Arizona  facility and a new facility located next to our
Corporate Headquarters in Maryland Heights, Missouri.

Suppliers

     We maintain an extensive inventory in our mail pharmacies of brand name and
generic  pharmaceuticals.  If a drug is not in our  inventory,  we can generally
obtain it from a supplier  within one or two  business  days.  We  purchase  our
pharmaceuticals  either  directly  from  manufacturers  or through  wholesalers.
During 1999,  approximately  78.7% of our pharmaceutical  purchases were through
one  wholesaler,  most  of  which  were  brand  name  pharmaceuticals.   Generic
pharmaceuticals are generally purchased directly from manufacturers.  We believe
that   alternative   sources  of  supply  for  most   generic   and  brand  name
pharmaceuticals are readily available.

Clients

     We are a major  provider  of PBM  services to the  managed  care  industry,
including  several  large HMOs,  and the employer  industry,  both  directly and
through third-party  administrators.  Excluding UHC, some of our largest managed
care clients are Aetna U.S.  Healthcare,  Inc.  ("Aetna"),  Oxford Health Plans,
Blue Cross Blue Shield of Massachusetts  and Blue Shield of California.  Some of
our  largest  employer  groups  include  the  State  of  New  York  Empire  Plan
Prescription  Drug Program  (through a  subcontracting  relationship  with CIGNA
HealthCare), and the State of Ohio Bureau of Workers' Compensation Fund. We also
market  our  PBM  services  through  preferred  provider  organizations,   group
purchasing organizations,  health insurers, third-party administrators of health
plans and union-sponsored benefit plans.

     With the completion of the DPS acquisition,  UHC became our largest client,
with approximately 9.5 million members. Our contract with UHC will expire on May
31, 2000,  and UHC has  indicated it will be moving to another  provider at that
time. We  negotiated a transition  arrangement  with UHC,  whereby their members
will be transitioned to their new provider beginning in June 2000 and continuing
throughout  the  remainder  of  2000.  In our  financial  analysis  of  the  DPS
acquisition,  we assumed UHC would not renew its  contract.  However,  if we are
unable to reduce our costs on a basis  commensurate  with our  expectations  and
manage the transition of this large client to another  provider both efficiently
and  effectively,  the  termination  of this contract may  materially  adversely
affect our business and results of operations.

Acquisitions and Strategic Alliances

     On October 13,  1999,  YourPharmacy.com,  Inc.  ("YPC"),  our  wholly-owned
subsidiary,  completed its contribution of certain operating assets constituting
its e-commerce  business in prescription and  non-prescription  drugs and health
and beauty aids to PlanetRx in exchange for 19.9%, or 10,369,990  shares, of the
common equity of PlanetRx (the "Shares"). In addition,  PlanetRx assumed certain
obligations of YPC.  Simultaneously,  PRX Acquisition Corp.  ("Acquisition Sub")
merged  into  PlanetRx  and  shareholders  of  PlanetRx  received  stock  in PRX
Holdings,  Inc.  ("Holdings"),  which  changed its name to  "PlanetRx.com  Inc."
Additionally,  PlanetRx assumed options granted to YPC employees which converted
into options to purchase  approximately  1.8 million  shares of PlanetRx  common
stock. The consummation of the transaction  occurred  immediately  preceding the
closing of PlanetRx's  initial public offering ("IPO") of common stock. Based on
the  IPO  price  of  $16  per  share,  YPC  received   consideration  valued  at
approximately  $166  million.  The  terms  of the  transaction  were  determined
pursuant to arms-length negotiations.

     Pursuant to the Contribution  Agreement,  PlanetRx  appointed our designee,
Barrett A. Toan,  our President  and Chief  Executive  Officer,  to its board of
directors  on October 19,  1999.  It also agreed to include our  designee in the
group of  nominees  that it  recommends  for  election  at each  meeting  of its
stockholders to elect directors as long as our percentage  beneficial  ownership
is not less than 5%.

     In  connection  with the IPO,  YPC agreed not to dispose of or hedge any of
its common stock or securities  convertible  into or exchangeable  for shares of
common stock for 180 days after  October 7, 1999,  except with the prior written
consent of the lead  underwriters  for the PlanetRx  IPO. The lead  underwriter,
however, may in its sole discretion,  at any time without notice, release all or
any portion of the shares subject to lock-up agreements.

     On August 31, 1999, we entered into an agreement with PlanetRx  pursuant to
which we designated  PlanetRx as our exclusive  Internet  pharmacy in the United
States for a term of five years,  with a right to  participate  in our  pharmacy
network for ten years.  The  agreement  also  provides for various  co-operative
marketing  activities  between  PlanetRx  and us.  Pursuant  to this  agreement,
PlanetRx  will  make  certain  payments  to us  annually  over  the  term of the
agreement,  with a minimum payment  obligation of $11,650,000  annually for five
years, plus reimbursement of certain expenses in the amount of $3,000,000,  with
a  potential  five year  extension  (subject  to  certain  conditions),  plus an
incremental fee based on our members'  activity on PlanetRx's  website.  We have
committed to exclusively co-brand and co-market PlanetRx as our online pharmacy.
Co-branding  includes,  but is not limited to, placing PlanetRx's name, logo and
other  information  about  PlanetRx  on our  website  and  marketing  and  sales
materials.  Co-marketing  includes our promoting PlanetRx as our online pharmacy
in our marketing and sales activities. The agreement became effective on October
13, 1999. As part of the  relationship,  PlanetRx agreed to certain  exclusivity
provisions that preclude it from directly or indirectly  operating as a pharmacy
benefit manager.

     On April 1, 1999, we acquired DPS from SmithKline  Beecham  Corporation and
one of its affiliates for $715 million in cash,  which reflects a purchase price
adjustment for closing working  capital and  transaction  costs. We financed the
acquisition  and  refinanced  all of our existing  indebtedness  through a $1.05
billion  credit  facility and a $150 million senior  subordinated  bridge credit
facility.  The  acquisition  positioned  us as the  third  largest  PBM in North
America  in terms of  total  members  and  provided  us with one of the  largest
managed care membership bases of any PBM. In addition,  the acquisition provides
us with enhanced clinical capabilities, systems and technologies.

     On April 1, 1998,  we acquired  the PBM business  known as  "ValueRx"  from
Columbia/HCA  Healthcare  Corporation  for  approximately  $460 million in cash,
which  includes  approximately  $15 million in  transaction  costs and executive
severance costs.  Historically,  while ValueRx,  like us, served all segments of
the PBM market,  we primarily  focused on managed  care and smaller  self-funded
plan sponsors,  and ValueRx  concentrated on health insurance carriers and large
employer and union groups.  We believe the ValueRx  acquisition has provided and
will continue to provide us with additional resources and expertise,  which will
allow us to better  serve our clients and  competitively  pursue new business in
all segments of the PBM market.

     In January  1996,  we acquired the pharmacy  claim  processing  business of
Eclipse Claims  Services,  Inc., one of the largest  processors of  prescription
drug claims in Canada.  In  connection  with this  acquisition,  we entered into
five-year  exclusive  contracts  to  provide  PBM  services  in  Canada  to both
Prudential Insurance Company of America's Canadian Operations ("Prudential") and
Aetna Life Insurance Company of Canada ("Aetna").  The assets of Prudential were
previously  acquired by London Life Insurance Company ("London Life"), with whom
we  reached  an  agreement  whereby we would be the  exclusive  provider  of PBM
services to London Life.  In late 1997,  London Life was acquired by  Great-West
Lifeco.  Inc.  ("Great-West"),  who  receives  PBM  services  from  one  of  our
competitors  in Canada.  Great-West  decided not to continue using our services,
and we have transitioned their business to another provider.

     On December 31, 1995, we entered into a series of agreements  with American
HealthCare  Systems Purchasing  Partners,  L.P. (now known as Premier Purchasing
Partners,  L.P.;  the  "Premier  Partnership"),  a health care group  purchasing
organization  affiliated with APS Healthcare,  Inc. (now known as Premier, Inc.;
"Premier").  Premier is the largest  voluntary health care alliance in the U.S.,
formed as a result of the mergers in late 1995 of three  predecessor  alliances,
American HealthCare Systems, Premier Health Alliance and SunHealth Alliance. The
Premier alliance includes  approximately 215 integrated health care systems that
own or operate  approximately  800  hospitals  and are  affiliated  with another
approximately 900 hospitals.  Among other things, the agreements designate us as
Premier's   exclusive   preferred   provider  of  outpatient   PBM  services  to
shareholders  of Premier and their  affiliated  health care entities,  plans and
facilities which participate in the Partnership's  purchasing programs. The term
of the agreement is ten years,  subject to early  termination by the Partnership
at five  years,  upon  payment  to us of an early  termination  fee equal to the
unamortized portion of the advance discount, calculated as of the effective date
of termination,  attributable to the issuance of our Class A Common Stock to the
Premier  Partnership for all issuances other than the initial issuance of shares
(the May, 1996 issuance  discussed below).  Assuming no additional  issuances of
our Class A Common Stock to the Premier Partnership,  if the Premier Partnership
elects to terminate the agreements  effective  December 31, 2000, no termination
fee will be due.

     Under the terms of our agreements, Premier is required to promote us as its
preferred PBM provider.  An individual Premier member or affiliated managed care
plan is not required to enter into an agreement  with us, but if it does so, the
term of the  agreement  would be for five  years.  We now  provide  service to a
number of Premier affiliates.  In May 1996, as a result of the number of Premier
plan members  receiving  our PBM services and the outcome of certain  joint drug
purchasing initiatives,  we issued 454,546 shares of our Class A Common Stock to
the  Premier  Partnership.  The Premier  Partnership  could  become  entitled to
receive  up to an  additional  4,500,000  shares  of our  Class A Common  Stock,
depending  upon the number of members in  Premier-affiliated  managed care plans
that  contract  for  our PBM  services  during  the  term  of our  agreement.  A
calculation  is made on April 1 of each year to  determine  if a stock  issuance
will be made. Premier has asserted that is has earned certain additional shares.
We  disagree  with  this  contention,  and we are in  discussions  with  Premier
concerning this matter.  To date, we have not issued any additional  shares.  If
the Premier  Partnership earns stock totaling over 5% of our total voting stock,
it is  entitled  to have its  designee  nominated  for  election to our Board of
Directors.

     In November  1995, we entered into a ten-year  strategic  alliance with The
Manufacturers  Life Insurance Company  ("Manulife") one of the largest providers
of group  health  insurance  policies  in Canada,  pursuant  to which we are the
exclusive  provider of PBM services to Manulife.  As a result of this  alliance,
Manulife  can earn up to  approximately  474,000  shares  of our  Class A Common
Stock,  depending on its achievement of certain pharmacy claim volumes from 1996
to 2000.  To date,  we have not issued any shares to Manulife.  In addition,  if
Manulife  does not  terminate  the  alliance  in either year 6 or year 10 of the
agreement,  in each of such years it will  receive a warrant to  purchase  up to
237,000  shares of our Class A Common Stock  exercisable at 85% of the then fair
market value of such shares. The actual number of shares will depend upon claims
volume in such years. See Note 3 of Notes to Consolidated  Financial  Statements
in Item 8 herein for additional discussion concerning Manulife.

Company Operations

     General. In our various facilities in the United States, we own and operate
five mail  pharmacies  and six member  service/pharmacy  help desk call centers.
Electronic  pharmacy  claims  processing  is  principally  directed  through our
Maryland  Heights,  Missouri  facility then routed to the  appropriate  computer
platform at our  Maryland  Heights,  Missouri or Tempe,  Arizona  facility or at
facilities  operated by EDS and Perot Systems,  which  maintains  certain of our
computer hardware. At our Canadian facility, we have sales and marketing, client
services,   pharmacy  help  desk,  clinical,   provider  relations  and  certain
management information systems capabilities.

     Sales and  Marketing.  We market  and sell our PBM  services  in the United
States primarily through an internal staff of sales directors and sales managers
located  in  various   cities   throughout   the   United   States.   The  sales
representatives  are  supported  by a staff of client  service  representatives,
clinical  pharmacy  managers  and  business  analyst  consultants  who  focus on
assisting our clients in managing the rising trend in pharmacy costs.  Marketing
and sales in Canada are  conducted by  representatives  located in  Mississauga,
Ontario.  Although we  cross-sell  our  infusion  services  to our PBM  clients,
Infusion Services and Specialty  Distribution  Services also employ personnel to
sell these specific products.

     Member  Services.  Although we sell our  services to clients,  the ultimate
recipient of many of our  services are the members of health plans  sponsored by
our clients. We believe,  therefore,  that client satisfaction is dependent upon
member  satisfaction.  Members can call us  toll-free,  24 hours a day, 7 days a
week, to obtain information about their prescription drug plan. We employ member
service representatives who are trained to respond to member inquiries.

     Provider  Relations.  Our  Provider  Relations  group  is  responsible  for
contracting  and  administering  our pharmacy  networks.  To  participate in our
retail pharmacy networks,  pharmacists must meet certain  qualifications and are
periodically  required to represent to us that their  applicable state licensing
requirements are being maintained and that they are in good standing. Pharmacies
can contact our various pharmacy help desks toll-free,  24 hours a day, 7 days a
week, for information and assistance in filling  prescriptions  for members.  In
addition,  our Provider Relations group audits selected pharmacies in the retail
pharmacy  networks to determine  compliance  with the terms of the contract with
our clients or us.

     Clinical  Support.   Our  Health  Management  Services  Department  employs
clinical  pharmacists,  data  analysts  and  outcomes  researchers  who  provide
technical support for our PBM services.  These staff members assist in providing
high level  clinical  pharmacy  services  such as  formulary  development,  drug
information  programs,  clinical  interventions with physicians,  development of
drug therapy  guidelines and the evaluation of drugs for inclusion in clinically
sound  therapeutic   intervention   programs.  The  Health  Management  Services
Department also analyzes and prepares reports on clinical  pharmacy data for our
clients and conducts  specific data analyses to evaluate the  cost-effectiveness
of certain drug therapies.

     Information  Systems.  Our  Information  Systems  department  supports  our
pharmacy claims processing systems and other management information systems that
are essential to our operations.  Uninterrupted  point-of-sale electronic retail
pharmacy claims processing is a significant  operational requirement for us, and
we are in the process of integrating  the systems  acquired with the ValueRx and
DPS acquisitions  into an enhanced version of the system used by DPS. All claims
are presently  processed through our systems at our Maryland  Heights,  Missouri
facility and Tempe,  Arizona facility,  or at facilities  operated by Electronic
Data Systems Corporation ("EDS") and Perot Systems Corporation ("Perot Systems")
(EDS  maintains  the  computer  hardware  for the DPS systems at its facility in
Plano,  Texas and Perot Systems  maintains the computer hardware for the ValueRx
systems at its facility in Richardson, Texas). Our outsourcing arrangements with
Perot and EDS will be consolidated  under EDS in the second quarter of 2000. Our
historical claims processing  systems located in our Maryland Heights,  Missouri
and Tempe, Arizona facilities are designed to be redundant,  which enables us to
do substantially  all claims processing in one facility if the other facility is
unable to process  claims.  Disaster  recovery  services for the ValueRx and DPS
systems are provided by a third party. We have  substantial  capacity for growth
in our claims processing facilities.

Competition

     We believe the primary  competitive  factors in each of our  businesses are
price,  quality of service and  breadth of  available  services.  We believe our
principal   competitive   advantages  are  our  size,  our   independence   from
pharmaceutical  manufacturer and drug store  ownership,  our strong managed care
and employer group customer base which supports the  development of advanced PBM
services and our commitment to provide  flexible and distinctive  service to our
clients. We believe our independence from pharmaceutical  manufacturer ownership
allows us to make unbiased formulary  recommendations to our clients,  balancing
both clinical  efficacy and cost, and our independence from drug store ownership
allows us to  construct  a  variety  or  convenient  and  cost-effective  retail
pharmacy  networks for our clients,  without  favoring any  particular  pharmacy
chain.  Some clients have indicated that this independence has been an important
factor in their decision making process.

     There are a large number of  companies  offering PBM services in the United
States.  Most of these companies are smaller than us and offer their services on
a local or  regional  basis.  We do,  however,  compete  with a number of large,
national companies,  including Merck-Medco Managed Care, L.L.C. (a subsidiary of
Merck & Co., Inc.), PCS, Inc. (a subsidiary of Rite-Aid  Corporation),  Caremark
Rx, Inc.,  and Advance  ParadigM,  Inc., as well as numerous  insurance and Blue
Cross  and  Blue  Shield  plans  and  certain  HMOs  which  have  their  own PBM
capabilities.  Several of these  other  companies  may have  greater  financial,
marketing and technological resources than us.

     In  general,  consolidation  is a  critical  factor  in the  pharmaceutical
industry, and particularly so in the PBM segment.  Competitors that are owned by
pharmaceutical  manufacturers  or drug store chains may have pricing  advantages
that are  unavailable  to us and other  independent  PBMs.  However,  we believe
independence  from  pharmaceutical  manufacturer  and drug  store  ownership  is
important to certain clients,  and we believe this  independence  provides us an
advantage in marketing to those clients.

     Some of our PBM services,  such as disease  management  services,  informed
decision  counseling  services  and  medical  information  management  services,
compete with those being offered by  pharmaceutical  manufacturers,  other PBMs,
large  national  companies,   specialized   disease  management   companies  and
information  service  providers.  Our non-PBM  services compete with a number of
large national companies as well as with local providers.

Government Regulation

     Various  aspects of our  businesses  are governed by federal and state laws
and  regulations.  Since  sanctions may be imposed for violations of these laws,
compliance  is a  significant  operational  requirement.  We  believe  we are in
substantial  compliance  with all existing  legal  requirements  material to the
operation  of our  businesses.  There are,  however,  significant  uncertainties
involving the  application of many of these legal  requirements to our business.
In addition, there are numerous proposed health care laws and regulations at the
federal and state levels, many of which could adversely affect our business.  We
are unable to predict what additional federal or state legislation or regulatory
initiatives  may be enacted in the future relating to our business or the health
care industry in general,  or what effect any such  legislation  or  regulations
might  have on us.  We  cannot  provide  any  assurance  that  federal  or state
governments will not impose additional  restrictions or adopt interpretations of
existing  laws that could  have a material  adverse  affect on our  business  or
financial position.

     Pharmacy  Benefit  Management  Regulation  Generally.  Certain  federal and
related  state  laws and  regulations  affect or may  affect  aspects of our PBM
business. Among these are the following:

         FDA Regulation. The U.S. Food and Drug Administration ("FDA") generally
has authority to regulate drug  promotional  materials that are disseminated "by
or on behalf of" a drug manufacturer.  In January, 1998, the FDA issued a Notice
and Draft Guidance  regarding its intent to regulate  certain drug promotion and
switching activities of pharmacy benefit managers that are controlled,  directly
or indirectly, by drug manufacturers. The position taken by the FDA in the Draft
Guidance was that  promotional  materials used by an independent  PBM or managed
care  organization  may  be  subject  to  FDA  regulation   depending  upon  the
circumstances, including the nature of the relationship between the PBM, the HMO
and the  manufacturer.  We, along with various other parties,  submitted written
comments  to the FDA  regarding  the  basis  for FDA  regulation  of PBM and HMO
activities.  It was our position that,  while the FDA may have  jurisdiction  to
regulate  drug   manufacturers,   the  Draft  Guidance  went  beyond  the  FDA's
jurisdiction.  After  extending  the  comment  period due to  numerous  industry
objections  to the proposed  Draft,  the FDA withdrew the Draft  Guidance in the
fall of 1998,  stating that it would  reconsider  the basis for such a Guidance.
The FDA has not addressed the issue since the  withdrawal  and has not indicated
when or even if it will continue to address the issue. However,  there can be no
assurance  that the FDA will not  again  attempt  to  assert  jurisdiction  over
certain aspects of our PBM business in the future and, in such event, the impact
could materially adversely affect our operations.

         Anti-Remuneration/Fraud  and Abuse Laws.  Federal law prohibits,  among
other things, an entity from paying or receiving,  subject to certain exceptions
and "safe  harbors,"  any  remuneration  to induce the  referral of  individuals
covered by federally funded health care programs,  including Medicare,  Medicaid
and  CHAMPUS  or the  purchase  (or the  arranging  for or  recommending  of the
purchase)  of items or services  for which  payment may be made under  Medicare,
Medicaid, CHAMPUS or other federally-funded health care programs. Several states
also have similar  laws that are not limited to services  for which  Medicare or
Medicaid  payment  may be made.  State  laws  vary and  have  been  infrequently
interpreted  by courts or regulatory  agencies.  Sanctions  for violating  these
federal and state anti-remuneration laws may include imprisonment,  criminal and
civil  fines,  and  exclusion  from  participation  in the Medicare and Medicaid
programs.

         The federal statute has been interpreted  broadly by courts, the Office
of Inspector General ("OIG") within the Department of Health and Human Services,
and administrative bodies. Because of the federal statute's broad scope, federal
regulations establish certain "safe harbors" from liability.  Safe harbors exist
for  certain  properly  reported  discounts   received  from  vendors,   certain
investment  interests,  certain properly  disclosed  payments made by vendors to
group purchasing  organizations,  and certain discount and payment  arrangements
between PBMs and HMO risk contractors  serving Medicaid and Medicare members.  A
practice  that does not fall within a safe harbor is not  necessarily  unlawful,
but may be subject to scrutiny and  challenge.  In the absence of an  applicable
exception or safe harbor,  a violation of the statute may occur even if only one
purpose of a payment  arrangement is to induce  patient  referrals or purchases.
Among the practices that have been identified by the OIG as potentially improper
under the statute are certain  "product  conversion  programs" in which benefits
are given by drug  manufacturers  to  pharmacists  or physicians  for changing a
prescription  (or  recommending  or  requesting  such a change) from one drug to
another. Such laws have been cited as a partial basis, along with state consumer
protection laws discussed below, for investigations and multi-state  settlements
relating  to  financial  incentives  provided  by drug  manufacturers  to retail
pharmacies in connection with such programs.

         To our knowledge, these anti-remuneration laws have not been applied to
prohibit PBMs from receiving amounts from drug  manufacturers in connection with
drug purchasing and formulary management programs,  to therapeutic  intervention
programs conducted by independent PBMs, or to the contractual relationships such
as those we have with certain of our clients. It has recently been reported that
the U.S.  Attorney's  Office in Philadelphia has issued subpoenas to Merck-Medco
and PCS, both PBMs, and Schering-Plough Corp., a pharmaceutical manufacturer. We
have not been served  with any such  subpoena,  nor are we privy to  information
concerning the scope of information being requested by these subpoenas. However,
the U.S.  Attorney's  Office has been  quoted to the effect that one issue being
investigated  is whether  certain  practices  engaged  in by those PBMs  violate
certain  anti-remuneration  statutes.  We  believe  that  we are in  substantial
compliance with the legal requirements imposed by such laws and regulations, and
we believe that there are material differences between  drug-switching  programs
that have  historically  been  challenged  under these laws and the  programs we
offer to our clients.  However,  there can be no  assurance  that we will not be
subject  to  scrutiny  or  challenge  under such laws or  regulations.  Any such
challenge could have a material adverse effect on us.

     ERISA  Regulation.  The  Employee  Retirement  Income  Security Act of 1974
("ERISA")  regulates  certain  aspects of employee  pension  and health  benefit
plans,   including  self-funded  corporate  health  plans  with  which  we  have
agreements to provide PBM services.  We believe that the conduct of our business
is not subject to the fiduciary  obligations of ERISA,  and our agreements  with
our clients  support this  contention by providing that we are not the fiduciary
of the  applicable  plan.  However,  there  can be no  assurance  that  the U.S.
Department of Labor,  which is the agency that enforces ERISA,  would not assert
that the fiduciary  obligations  imposed by the statute apply to certain aspects
of our operations.

     In addition to its fiduciary  provisions,  ERISA imposes civil and criminal
liability  on service  providers to health  plans and certain  other  persons if
certain forms of illegal remuneration are made or received.  These provisions of
ERISA are  similar,  but not  identical,  to the health  care  anti-remuneration
statutes discussed in the immediately  preceding section;  in particular,  ERISA
lacks the statutory and regulatory "safe harbor"  exceptions  incorporated  into
the health  care  statute.  Like the health  care  anti-remuneration  laws,  the
corresponding  provisions of ERISA are broadly written and their  application to
particular cases is often uncertain. We have implemented policies, which include
disclosure to health plan sponsors  with respect to any  commissions  paid by us
that might fall within the scope of such provisions,  and accordingly believe we
are in substantial  compliance with these provisions of ERISA.  However,  we can
provide no  assurance  that our  policies in this  regard  would be found by the
appropriate enforcement authorities to meet the requirements of the statute.

     Proposed Changes in Canadian  Healthcare  System. In Canada, the provincial
health plans  provide  universal  coverage for basic health care  services,  but
prescription  drug coverage under the government  plans is provided only for the
elderly  and the  indigent.  In late  1997,  a  proposal  was made by a  federal
government  health care task force to include  coverage for  prescription  drugs
under the provincial  health insurance plans,  which was endorsed by the federal
government's  Health  Minister.  This  report was  advisory  in nature,  and not
binding upon the federal or provincial  governments.  We believe this initiative
is dormant at the present time, and we are unable to determine the likelihood of
adoption of the proposal in the future.

     Numerous  state  laws  and  regulations  also  affect  aspects  of our  PBM
business. Among these are the following:

         Comprehensive PBM Regulation.  Although no state has passed legislation
regulating PBM activities in a comprehensive  manner,  such legislation has been
introduced in the past in California,  New Jersey, Colorado, Texas and Virginia.
Such  legislation,  if  enacted  in a  state  in  which  we  have a  significant
concentration of business, could adversely impact our operations.

         Consumer  Protection  Laws.  Most states have consumer  protection laws
that have been the basis for investigations and multi-state settlements relating
to financial  incentives  provided by drug manufacturers to retail pharmacies in
connection with drug switching programs.  In addition,  pursuant to a settlement
agreement  entered into with seventeen  states on October 25, 1995,  Merck-Medco
Managed Care, LLC ("Medco"),  the PBM subsidiary of pharmaceutical  manufacturer
Merck & Co.,  agreed to have  pharmacists  affiliated  with Medco  mail  service
pharmacies  disclose to  physicians  and  patients the  financial  relationships
between  Merck,  Medco,  and the mail  service  pharmacy  when such  pharmacists
contact physicians seeking to change a prescription from one drug to another. We
believe that our contractual  relationships  with drug  manufacturers and retail
pharmacies  do  not  include  the  features  that  were  viewed  by  enforcement
authorities as problematic in these settlement agreements. However, no assurance
can be given that we will not be subject to scrutiny or  challenge  under one or
more of these laws.

         Network Access Legislation.  A majority of states now have some form of
legislation affecting our ability to limit access to a pharmacy provider network
or from  removing  network  providers.  Such  legislation  may require us or our
clients to admit any retail pharmacy  willing to meet the plan's price and other
terms for network  participation  ("any willing provider"  legislation);  or may
provide that a provider may not be removed from a network  except in  compliance
with certain procedures ("due process" legislation). We have not been materially
affected by these  statutes  because we maintain a large  network of over 53,000
retail  pharmacies  and will  admit any duly  licensed  pharmacy  that meets our
participation  criteria,  which  address  such  matters as adequacy of insurance
coverage, minimum hours of operation, and the absence of disciplinary actions by
relevant state and federal agencies.

         Legislation Affecting Plan Design. Some states have enacted legislation
that  prohibits  certain types of managed care plan  sponsors from  implementing
certain restrictive design features, and many states have introduced legislation
to regulate various aspects of managed care plans, including provisions relating
to the pharmacy benefit.  For example,  some states, under so-called "freedom of
choice" legislation, provide that members of the plan may not be required to use
network  providers,  but must  instead be provided  with  benefits  even if they
choose to use  non-network  providers.  Other  states have  enacted  legislation
purporting to prohibit health plans from offering members  financial  incentives
for use of mail service  pharmacies.  Legislation  has been  introduced  in some
states to prohibit or restrict therapeutic intervention,  or to require coverage
of all FDA approved drugs.  Other states mandate coverage of certain benefits or
conditions, and require coverage of specific drugs if deemed medically necessary
by the prescribing  physician.  Such legislation does not generally apply to us,
but it may apply to certain of our clients (HMOs and health  insurers).  If such
legislation  were to become widely adopted and broad in scope, it could have the
effect of limiting the economic  benefits  achievable  through  pharmacy benefit
management. This could have a material adverse effect on our business.

         Licensure  Laws.  Many  states  have  licensure  or  registration  laws
governing certain types of ancillary health care organizations,  including PPOs,
TPAs, and companies that provide utilization review services. The scope of these
laws differs significantly from state to state, and the application of such laws
to the  activities  of  pharmacy  benefit  managers  often is  unclear.  We have
registered  under such laws in those  states in which we have  concluded,  after
discussion  with  the  appropriate  state  agency,  that  such  registration  is
required.  Because of increased  regulatory  requirements on some of our managed
care clients affecting prior authorization of drugs before coverage is approved,
we have elected to obtain utilization review licenses in selected states through
our new ESI  Utilization  Management  Co. In addition,  accreditation  agencies'
requirements  on managed  care  organizations  may also affect  those  delegated
services we provide to such organizations.

         Legislation  Affecting Drug Prices.  Some states have adopted so-called
"most favored nation" legislation providing that a pharmacy participating in the
state  Medicaid  program  must give the state the best price  that the  pharmacy
makes available to any third party plan. Such  legislation may adversely  affect
our ability to negotiate discounts in the future from network pharmacies.  Other
states have enacted  "unitary  pricing"  legislation,  which  mandates  that all
wholesale  purchasers  of drugs  within  the  state be given  access to the same
discounts and incentives.  Such  legislation has been introduced in the past but
not enacted in Missouri,  Arizona,  Pennsylvania,  New York, and New Mexico, all
states where we operate mail service pharmacies. Such legislation, if enacted in
a state where one of our mail service  pharmacies  is located,  could  adversely
affect our ability to negotiate  discounts on our purchase of prescription drugs
to be dispensed by our mail service pharmacies.

         Regulation of Financial Risk Plans.  Fee-for-service  prescription drug
plans are generally not subject to financial regulation by the states.  However,
if the PBM offers to provide  prescription drug coverage on a capitated basis or
otherwise  accepts  material  financial  risk in providing the benefit,  laws in
various  states may regulate  the plan.  Such laws may require that the party at
risk establish reserves or otherwise demonstrate financial responsibility.  Laws
that may apply in such cases include insurance laws, HMO laws or limited prepaid
health  service plan laws. In those cases in which we have contracts in which we
are  materially  at risk to provide  the  pharmacy  benefit,  we believe we have
complied with all applicable laws.

         Many of these state laws may be preempted in whole or in part by ERISA,
which provides for comprehensive  federal  regulation of employee benefit plans.
However,  the  scope  of  ERISA  preemption  is  uncertain  and  is  subject  to
conflicting  court  rulings,  and in any event we  provide  services  to certain
clients, such as governmental  entities,  that are not subject to the preemption
provisions  of ERISA.  Other state laws may be invalid in whole or in part as an
unconstitutional  attempt by a state to regulate  interstate  commerce,  but the
outcome of  challenges  to these laws on this basis is  uncertain.  Accordingly,
compliance  with  state  laws  and  regulations  is  a  significant  operational
requirement for us.

         Mail Pharmacy  Regulation.  Our mail service  pharmacies are located in
Arizona, Missouri, New Mexico, New York and Pennsylvania, and we are licensed to
do business  as a pharmacy in each such state.  Many of the states into which we
deliver pharmaceuticals have laws and regulations that require out-of-state mail
service pharmacies to register with, or be licensed by, the board of pharmacy or
similar  regulatory body in the state.  These states  generally  permit the mail
service  pharmacy to follow the laws of the state  within which the mail service
pharmacy  is  located,  although  two  states  require  that  we also  employ  a
pharmacist  licensed in their state.  We have registered our pharmacies in every
state in which, to our knowledge, such registration is required.

         One  state has a statute  that  purports  to  prohibit  residents  from
obtaining  prescription  drugs by mail if the mail order business of the company
dispensing  the  drugs  represents  more  than  a  specified  percentage  of the
company's total volume of pharmacy business. The statute is ambiguous in certain
respects,  but we do not believe  our mail order  volume  exceeds the  threshold
percentage.  We are licensed as a pharmacy in that state. No enforcement  action
has been taken  under the  statute  against  us, and to our  knowledge,  no such
enforcement action is contemplated. Approximately 2.4% of our revenues come from
mail delivery of prescription  drugs into that state.  If an enforcement  action
were  commenced  against us under that  statute,  we would  consider  all of our
alternatives,  including  challenging  the  validity of the  statute.  A bill is
pending in that state to repeal the mail service prohibition.

         Other  statutes and  regulations  affect our mail  service  operations.
Federal statutes and regulations govern the labeling, packaging, advertising and
adulteration of prescription drugs and the dispensing of controlled  substances.
The Federal Trade  Commission  requires mail order sellers of goods generally to
engage in truthful  advertising,  to stock a reasonable supply of the product to
be sold,  to fill mail orders within  thirty days,  and to provide  clients with
refunds  when  appropriate.  The United  States  Postal  Service  has  statutory
authority to restrict the  transmission of drugs and medicines  through the mail
to a degree that could have an adverse effect on our mail service operations.

         Regulation  of Informed  Decision  Counseling  and  Disease  Management
Services.  Our health care decision  support  counseling and disease  management
programs are affected by many of the same types of state laws and regulations as
our other activities.  In addition, all states regulate the practice of medicine
and the practice of nursing.  We do not believe our informed decision counseling
or disease management  activities  constitute either the practice of medicine or
the practice of nursing.  However,  there can be no assurance  that a regulatory
agency in one or more states may not assert a contrary position,  and we are not
aware of any controlling legal precedent for services of this kind.

         Privacy and Confidentiality Legislation. Most of our activities involve
the receipt or use of confidential,  medical information  concerning  individual
members.  In addition,  we use aggregated  and anonymized  data for research and
analysis  purposes.  Regulations  have been  proposed at the  federal  level and
legislation has been proposed,  and in some cases enacted,  in several states to
restrict the use and disclosure of confidential medical information. To date, no
such legislation has been enacted that adversely  impacts our ability to provide
our services,  but there can be no assurance  that federal or state  governments
will not enact  legislation,  impose  restrictions or adopt  interpretations  of
existing laws that could have a material adverse effect on our operations.

         In November 1999,  the Department of Health and Human Services  ("HHS")
issued draft privacy regulations,  pursuant to the Health Insurance  Portability
and Accountability Act of 1996 ("HIPAA"), which impose extensive restrictions on
the use and disclosure of individually identifiable health information.  HHS has
received comments to the proposed regulations and it is not known when they will
be finalized.  At such time as the  regulations  are  finalized,  we expect that
there will be a two-year  implementation  period within which we must comply. We
are unable to predict  accurately what effect the final  regulations may have on
us, and there can be no assurance  that the  restrictions  and duties imposed by
the regulations will not have a material adverse effect on our business, results
of operations or financial condition.

     Non-PBM  Regulatory  Environment.  Our  non-PBM  activities  operate  in  a
regulatory environment that is quite similar to that of our PBM activities.

     Regulation of Infusion  Therapy  Services.  Our infusion  therapy  services
business  is subject to many of the same or similar  federal  and state laws and
regulations  affecting  our  pharmacy  benefit  management  business,  including
anti-remuneration,  physician self-referral, and other fraud and abuse type laws
and  regulations.  In addition,  some states  require that providers of infusion
therapy  services be  licensed.  We are  licensed  as a home  health  agency and
pharmacy in Texas, as a residential service agency and pharmacy in Maryland, and
as a pharmacy in New Jersey,  Missouri,  Arizona and  Pennsylvania.  We are also
licensed as a non-resident pharmacy in various states. We believe that we are in
substantial compliance with such licensing requirements.

     The  Joint  Commission  on   Accreditation   of  Healthcare   Organizations
("JCAHO"), a non-profit, private organization, has established written standards
for health care  organizations and home care services,  including  standards for
services  provided  by home  infusion  therapy  companies.  All of our  infusion
therapy facilities have received JCAHO accreditation,  which allows us to market
infusion  therapy services to Medicare and Medicaid  programs.  If we expand our
home  infusion  therapy  services  to other  states or to  Medicare  or Medicaid
programs,  we  may  be  required  to  comply  with  other  applicable  laws  and
regulations.

     Future  Regulation.  We are unable to predict  accurately  what  additional
federal or state  legislation  or regulatory  initiatives  may be enacted in the
future  relating to our  businesses or the health care  industry in general,  or
what effect any such  legislation or regulations  might have on us. There can be
no  assurance  that  federal or state  governments  will not  impose  additional
restrictions  or adopt  interpretations  of  existing  laws  that  could  have a
material adverse effect on our business or financial position.

Service Marks and Trademarks

     We, and our  subsidiaries,  have  registered  the  service  marks  "Express
Scripts", "PERx", "ExpressComp", "ExpressReview", "ExpressTherapeutics", "IVTx",
"PERxCare",  "PERxComp",  "RxWizard", "PTE", "ValueRx", "Value Health, Inc." and
"Diversified", among others, with the United States Patent and Trademark Office.
Our rights to these  marks will  continue  so long as we comply  with the usage,
renewal filing and other legal  requirements  relating to the renewal of service
marks.  We are in the  process of applying  for  registration  of several  other
trademarks  and  service  marks.  If we are  unable  to  obtain  any  additional
registrations,  we believe  there  would be no  material  adverse  effect on our
business.

Insurance

     Our PBM operations,  including the dispensing of pharmaceutical products by
our mail service  pharmacies,  and the services  rendered in connection with our
disease management and informed decision  counseling  services,  and our non-PBM
operations,  such as the products and services  provided in connection  with our
infusion  therapy  programs  (including the associated  nursing  services),  may
subject  us to  litigation  and  liability  for  damages.  We  believe  that our
insurance protection is adequate for our present business operations,  but there
can be no  assurance  that we will be able  to  maintain  our  professional  and
general  liability  insurance  coverage  in the  future or that  such  insurance
coverage will be available on  acceptable  terms or adequate to cover any or all
potential  product or professional  liability  claims.  A successful  product or
professional  liability  claim in excess of our insurance  coverage,  or one for
which an exclusion from coverage  applies,  could have a material adverse effect
upon our financial position or results of operations.

Employees

     As of March 1, 2000, we employed a total of 4,529 employees in the U.S. and
77 employees in Canada.  Approximately 504 of the U.S.  employees are members of
collective  bargaining  units.  Specifically,  we employ  members of the Service
Employees International Union at our Bensalem, Pennsylvania facility, members of
the United Auto Workers Union at our Farmington Hills,  Michigan  facility,  and
members  of the  United  Food  and  Commercial  Workers  Union  ("UFCW")  at our
Albuquerque,  New  Mexico  facility.  We  believe  our  relationships  with  our
employees and our unions are good.

Executive Officers of the Registrant

     Pursuant to General Instruction G(3) of the Annual Report on Form 10-K, the
information  regarding our executive officers required by Item 401 of Regulation
S-K is hereby included in Part I of this report.

     Our executive officers and their ages as of March 1, 2000 are as follows:

               Name              Age             Position

     Howard L. Waltman           67    Chairman of the Board
     Barrett A. Toan             52    President, Chief Executive
                                         Officer and Director
     David A. Lowenberg          50    Chief Operating Officer
     Terrence D. Arndt           56    Senior Vice President of Marketing
     Stuart L. Bascomb           58    Executive Vice President - Sales
                                         and Provider Relations and
                                         Director
     Thomas M. Boudreau          48    Senior Vice President, General
                                         Counsel and Secretary
     Mabel F. Chen               57    Senior Vice President and
                                         Director of Site Operations
     Robert W. (Joe) Davis       53    Senior Vice President and Chief
                                         Information Systems Officer
     Mark O. Johnson             46    Senior Vice President of
                                         Administration
     Linda L. Logsdon            52    Executive Vice President of
                                         Health Management Services
     George Paz                  44    Senior Vice President and Chief
                                         Financial Officer
     Joseph W. Plum              52    Vice President and Chief
                                         Accounting Officer

     Mr.  Waltman was elected  Chairman of the Board in March 1992.  Mr. Waltman
has been one of our  directors  since our  inception  in  September  1986.  From
September  1992 to December 31, 1995,  Mr. Waltman served as the Chairman of the
Board  of  NYLCare  Health  Plans,  Inc.,  which  was an  indirect  wholly-owned
subsidiary of New York Life Insurance Company at the time.

     Mr. Toan was elected  Chief  Executive  Officer in March 1992 and President
and a director in October 1990. Mr. Toan has been an executive  employee of ours
since May 1989.

     Mr.  Lowenberg was elected our Chief  Operating  Officer in September 1999,
also served as Director of Site  Operations  from October  1994 until  September
1999 and Vice President in November  1993. Mr.  Lowenberg also served as General
Manager of the Tempe facility from March 1993 until January 1995.

     Mr. Arndt joined us and was elected  Senior Vice  President of Marketing in
April 1999.  Prior to joining us, Mr. Arndt was  President  and Chief  Operating
Officer  of EDI USA from  July  1997 to April  1999.  Mr.  Arndt  served as Vice
President of Business  Development  for Card  Establishment  Services,  a former
division of CitiBank  owned by the firm of Welsh,  Carson,  Anderson  and Stowe,
from July 1994 to July 1997.

     Mr.  Bascomb  was  elected  Executive  Vice  President  in March 1989 and a
director  in  January  2000,  and also  served as Chief  Financial  Officer  and
Treasurer from March 1992 until May 1996. Since May 1996, Mr. Bascomb has served
as Executive Vice President - Sales and Provider Relations.

     Mr.  Boudreau  was  elected  Senior  Vice  President,  General  Counsel and
Secretary in October  1994.  He has served as General  Counsel  since June 1994.
From September 1984 until June 1994, Mr. Boudreau was a partner in the St. Louis
law firm of Husch & Eppenberger.

     Ms. Chen was elected Senior Vice President and Director of Site  Operations
in November  1999.  From March 1996 until November 1999, Ms. Chen served as Vice
President  and General  Manager of our Tempe  facility.  From January 1995 until
joining  Express  Scripts,  Ms. Chen served as the  Director of Medicaid for the
State of Arizona.

     Mr. Davis was elected Senior Vice President and Chief  Information  Systems
Officer in September  1997.  Mr. Davis served as Director of Technical  Services
and Computer  Operations  from July 1993 until July 1995,  and as Vice President
and General  Manager of our St. Louis  Operations from July 1995 until September
1997.

     Mr.  Johnson was elected  Senior Vice President of Integration in May 1999,
and has served as Senior Vice President of  Administration  since February 2000.
Prior to joining us, Mr.  Johnson  served as  President  of DPS from May 1998 to
April 1999 and Senior Vice  President,  Client Service and Sales of DPS from May
1997 to May 1998.  From August 1996 to May 1997,  Mr.  Johnson was President and
Chief Executive Officer of American Day Treatment  Center,  Inc. and also served
as Executive Vice President,  Operations and Chief Operating  Officer from March
1992 to August 1996.

     Ms.  Logsdon was elected  Executive  Vice  President  of Health  Management
Services in May 1999, and served as Senior Vice  President of Health  Management
Services from May 1997 until May 1999.  Ms.  Logsdon served as Vice President of
Demand and  Disease  Management  from  November  1996  until May 1997.  Prior to
joining us in November  1996,  Ms. Logsdon served as Vice President of Corporate
Services   and  Chief   Operating   Officer  of  United   HealthCare's   Midwest
Companies-GenCare/Physicians  Health Plan/MetraHealth,  a St. Louis-based health
maintenance  organization,  from February  1995 to October  1996,  and as Deputy
Director/Vice  President of GenCare Health Systems, Inc., also a St. Louis-based
health maintenance organization, from June 1992 to February 1995.

     Mr. Paz joined us and was elected Senior Vice President and Chief Financial
Officer  in  January  1998.  Prior to  joining  us, Mr. Paz was a partner in the
Chicago  office of Coopers & Lybrand from  December 1995 to December  1997,  and
served as Executive Vice President and Chief Financial  Officer of Life Partners
Group, Inc., a life insurance company, from October 1993 until December 1995.

     Mr. Plum was elected Vice President in October 1994 and has served as Chief
Accounting Officer since March 1992 and Corporate Controller since March 1989.

Forward Looking Statements and Associated Risks

     Information  that we have  included or  incorporated  by  reference in this
Annual Report on Form 10-K, and  information  that may be contained in our other
filings with the SEC and our press releases or other public statements,  contain
or may contain  forward-looking  statements.  These  forward-looking  statements
include,  among others,  statements of our plans,  objectives,  expectations  or
intentions.

     Our forward-looking statements involve risks and uncertainties.  Our actual
results  may differ  significantly  from those  projected  or  suggested  in any
forward-looking  statements.  We do not  undertake  any  obligation  to  release
publicly any revisions to such  forward-looking  statements to reflect events or
circumstances  occurring  after the date hereof or to reflect the  occurrence of
unanticipated  events.  Factors  that  might  cause such a  difference  to occur
include, but are not limited to:

     o    risks associated with the  implementation  of our Internet  strategy

     o    risks  associated  with the  integration  of  ValueRx  and DPS

     o    risks  associated  with our leverage and debt  service  obligations

     o    risks  associated  with our  ability to manage and  maintain  internal
          growth

     o    competition,  including price competition,  competition in the bidding
          and  proposal   process  and  our  ability  to   consummate   contract
          negotiations  with prospective  clients

     o    the possible  termination of contracts with key clients or providers

     o    the possible loss of relationships with pharmaceutical  manufacturers,
          or  changes  in  pricing,  discount,  rebate  or  other  practices  of
          pharmaceutical manufacturers

     o    adverse results in litigation

     o    adverse  results  in  regulatory  matters,  the  adoption  of  adverse
          legislation or regulations,  more  aggressive  enforcement of existing
          legislation  or  regulations,  or a change  in the  interpretation  of
          existing legislation or regulations

     o    developments  in the health  care  industry,  including  the impact of
          increases in health care costs,  changes in drug utilization  patterns
          and  introductions  of  new  drugs

     o    dependence  on key members of management

     o    our relationship with New York Life Insurance Company, which possesses
          voting control of us

     o    other risks described from time to time in our filings with the SEC

These and other relevant factors,  including any other  information  included or
incorporated by reference in this Report,  and information that may be contained
in our other filings with the SEC, should be carefully considered when reviewing
any  forward-looking  statement.  The occurrence of any of the following  risks,
among  others,  could  materially  adversely  affect  our  business,  results of
operations and financial condition.

Failure to Implement Our Internet Strategy Could Adversely Affect Our Business

     We continue to implement and refine our Internet strategy, which will
generally  web-enable all components of the pharmacy benefit delivery  equation.
To the extent we do not  successfully  implement this  strategy,  we may be at a
competitive disadvantage compared to our competitors, which may adversely affect
our ability to attract and retain clients.

Failure to Integrate ValueRx and DPS Could Adversely Affect Our Business

     On April 1, 1998,  we completed  our first major  acquisition  by acquiring
Value  Health,  Inc.  and  Managed  Prescription  Network,  Inc.  (collectively,
"ValueRx"),  the  PBM  business  of  Columbia/HCA  Healthcare  Corporation,  for
approximately $460 million in cash. This transaction significantly increased our
membership  base and the  complexity  of our  operations.  On April 1, 1999,  we
completed our  acquisition  of  Diversified  Pharmaceutical  Services,  Inc. and
Diversified  Pharmaceutical Services (Puerto Rico), Inc.  (collectively,  "DPS")
from SmithKline  Beecham  Corporation and one of its affiliates for $715 million
in cash. In light of both  acquisitions,  we have developed and are implementing
an integration plan to address items such as:

     o    retention of key employees

     o    consolidation  of  administrative  and other  duplicative  functions

     o    coordination  of  sales,  marketing,  customer  service  and  clinical
          functions

     o    systems  integration

     o    new product and service development

     o    client retention and other items o facility consolidation

         While we have  achieved  many of our  integration  goals  to date  with
respect to the acquisitions,  certain significant integration challenges remain,
including the complete  integration of our information  technology  systems.  We
cannot provide any assurance that our integration plan will successfully address
all  aspects  of our  operations,  or that  we  will  continue  to  achieve  our
integration  goals.  In addition,  we assumed  specific  financial  targets when
deciding to purchase  ValueRx and DPS. We cannot  provide any assurance  that we
will be able to achieve our targets. Failure to do so could materially adversely
affect our results of operations or financial condition.

Our Leverage and Debt Service  Obligations  Could Impede Our Operations and
     Flexibility

     We  have  significant  leverage,   which  means  that  the  amount  of  our
outstanding  debt is large compared to the net book value of our assets,  and we
have substantial  repayment obligations and interest expense. As of December 31,
1999,  we have total  consolidated  debt of  approximately  $636  million  ($606
million  after  our  $30  million  repayment  in  January  2000).  We may  incur
additional indebtedness in the future.

     Our level of debt and the limitations  imposed on us by our debt agreements
could have important consequences, including the following:

                    o    we will have to use a  substantial  portion of our cash
                         flow from  operations  for debt service rather than for
                         our operations

                    o    we may not be able to obtain  additional debt financing
                         for future working  capital,  capital  expenditures  or
                         other  corporate  purposes

                    o    approximately  21% of the debt  under  our bank  credit
                         facility  is at a  variable  interest  rate,  making us
                         vulnerable to increases in interest rates

                    o    we could be less able to take  advantage of significant
                         business    opportunities,    such    as    acquisition
                         opportunities,  and  react  to  changes  in  market  or
                         industry conditions

                    o    we could be more vulnerable to general adverse economic
                         and  industry  conditions

                    o    we may be  disadvantaged  compared to competitors  with
                         less leverage

     Furthermore,  our ability to satisfy our  obligations,  including  our debt
service  requirements,  will be dependent upon our future  performance.  Factors
which  could  affect  our  future  performance   include,   without  limitation,
prevailing economic conditions and financial,  business and other factors,  many
of which are beyond our control and which affect our business and operations.

     Our bank credit  facility  is secured by the  capital  stock of each of our
existing and subsequently  acquired domestic  subsidiaries,  excluding  Practice
Patterns Science, Great Plains Reinsurance Company,  ValueRx of Michigan,  Inc.,
Diversified NY IPA, Inc. and Diversified  Pharmaceutical Services (Puerto Rico),
Inc., and 65% of the stock of our foreign subsidiaries. If we are unable to meet
our obligations under this bank credit facility,  these creditors could exercise
their rights as a secured party and take possession of the pledged capital stock
of these  subsidiaries.  This would  materially  adversely affect our results of
operations and financial condition.

Failure to Manage and Maintain  Internal Growth Could Adversely Affect
   Our Business

     We have experienced  rapid internal growth over the past several years. Our
ability to  effectively  manage and maintain this  internal  growth will require
that we continue to improve our financial and management  information systems as
well as identify and retain key  personnel.  We can provide no assurance that we
will  successfully  meet  these  requirements  or that we will  have  access  to
sufficient  capital to do so. Our  internal  growth is also  dependent  upon our
ability to attract new clients and achieve growth in the membership  base of our
existing clients. If we are unable to continue our client and membership growth,
our results of operations and financial  position could be materially  adversely
affected.

Competition Could Reduce Our Membership and Our Profit Margins

     Pharmacy benefit management is a very competitive business. Our competitors
include  several  large and  well-established  companies  that may have  greater
financial,   marketing  and  technological  resources  than  we  do.  One  major
competitor in the PBM business,  Merck-Medco  Managed Care,  L.L.C., is owned by
Merck  &  Co.,  Inc.,  a  large  pharmaceutical   manufacturer.   Another  major
competitor, PCS, Inc., is owned by Rite-Aid Corporation, a large retail pharmacy
chain. Both of these competitors may possess purchasing or other advantages over
us by virtue of their  ownership,  and could  succeed in taking away some of our
clients.   Consolidation  in  the  PBM  industry  may  also  lead  to  increased
competition among a smaller number of large PBM companies.  Competition may also
come from other sources in the future,  including from Internet-based  providers
such as Drugstore.com,  or from Internet-based  connectivity companies,  such as
Healtheon/WebMD.  We cannot predict what effect,  if any, these new  competitors
may have on the marketplace or on our business.

     Over the last several  years intense  competition  in the  marketplace  has
caused many PBMs, including us, to reduce the prices charged to clients for core
services and share a larger portion of the formulary  fees and related  revenues
received from drug manufacturers with clients. This combination of lower pricing
and increased  revenue sharing has caused our operating  margins to decline (see
"Management's  Discussion  and  Analysis of Financial  Condition  and Results of
Operations").  We expect to continue  marketing our services to larger  clients,
who typically have greater  bargaining  power than smaller  clients.  This might
create  continuing  pressure on our margins.  We can give no assurance  that new
services  provided to these  clients  will fully  compensate  for these  reduced
margins.

Failure to Retain Key Clients and Network Pharmacies Could Adversely Affect Our
    Business and Limit Our Access to Retail Pharmacies

     We currently provide PBM services to approximately 9,300 clients, including
several large clients.  Our  acquisitions  have  diversified our client base and
reduced our dependence on any single client. Our top 10 clients,  measured as of
January 1, 2000, but excluding  UHC,  represent  approximately  28% of our total
membership base, but no single client  represents more than  approximately 4% of
our membership  base. Our contracts with clients  generally do not have terms of
longer than three years and, in some cases,  are  terminable  by either party on
relatively short notice.  Our larger clients generally  distribute  requests for
proposals and seek bids from other PBM providers in advance of the expiration of
their  contracts.  If several of these large  clients  elect not to extend their
relationship  with us, and we are not successful in generating  sales to replace
the lost business, our future business and operating results could be materially
adversely  affected.  In  addition,  we believe  the  managed  care  industry is
undergoing substantial  consolidation,  and another party that is not our client
could acquire some of our managed care  clients.  In such case,  the  likelihood
such client would renew its PBM contract with us could be reduced.

     As  of  January  1,  2000,  UHC  represents   our  largest   client,   with
approximately  9.5 million members,  which accounts for approximately 20% of our
membership  base.  Our contract  with UHC expires on May 31, 2000,  and UHC will
begin  moving to another  provider at that time.  We have  developed a migration
plan to transition  the UHC  membership to their new provider  beginning in June
2000 and  continuing  its  migration of members  through the end of 2000. In our
financial  analysis of the DPS  acquisition,  we assumed UHC would not renew its
contract.  However, if we are unable to reduce our costs on a basis commensurate
with our  expectations and manage the transition of this large client to another
provider both  efficiently  and  effectively  based upon our migration plan, the
termination  of this contract may materially  adversely  affect our business and
results of operations.

     Our largest  national  provider network consists of more than 53,000 retail
pharmacies, which represent more than 99% of the retail pharmacies in the United
States.  However, the top 10 retail pharmacy chains represent  approximately 42%
of the 53,000  pharmacies,  with these pharmacy chains  representing even higher
concentrations in certain areas of the United States.  Our contracts with retail
pharmacies, which are non-exclusive, are generally terminable by either party on
relatively  short  notice.  If one or more of the top pharmacy  chains elects to
terminate its relationship with us, our members' access to retail pharmacies and
our business could be materially adversely affected. In addition, large pharmacy
chains either own PBMs today, as is the case with Rite-Aid  Corporation who owns
one of our major  competitors,  PCS,  Inc., or could attempt to acquire a PBM in
the future.  Ownership of PBMs by retail  pharmacy  chains  could have  material
adverse  effects  on our  relationships  with such  pharmacy  chains  and on our
business and results of operations.

     Loss of Relationships with Pharmaceutical  Manufacturers and Changes in the
Regulation   of  Discounts  and  Rebates   Provided  to  Us  by   Pharmaceutical
Manufacturers Could Decrease Our Profits

     We  maintain   contractual   relationships  with  numerous   pharmaceutical
manufacturers that provide us with:

                    o    discounts  at the  time we  purchase  the  drugs  to be
                         dispensed from our mail pharmacies

                    o    rebates  based  upon  sales  of  drugs  from  our  mail
                         pharmacies   and  through   pharmacies  in  our  retail
                         networks

                    o    administrative  fees  based  upon the  development  and
                         maintenance of formularies which include the particular
                         manufacturer's products

These  fees  are  all  commonly  referred  to as  formulary  fees  or  formulary
management fees.

     We also provide  various  services for, or services which are funded wholly
or partially by, pharmaceutical manufacturers. These services include:

                    o    compliance  programs,  which  involve  instruction  and
                         counseling  of patients  concerning  the  importance of
                         compliance with the drug treatment  regimen  prescribed
                         by their physician

                    o    therapy management programs, which involve education of
                         patients having specific  diseases,  such as asthma and
                         diabetes,  concerning the management of their condition

                    o    market   research   programs   in  which   we   provide
                         information   to    manufacturers    concerning    drug
                         utilization patterns.

These arrangements are generally  terminable by either party on relatively short
notice. If several of these arrangements are terminated or materially altered by
the  pharmaceutical  manufacturers,  our  operating  results could be materially
adversely affected. In addition,  formulary fee programs, as well as some of the
services we provide to the pharmaceutical  manufacturers,  have been the subject
of debate in  federal  and state  legislatures  and  various  other  public  and
governmental  forums.  Changes  in  existing  laws or  regulations  or in  their
interpretations,  or the adoption of new laws or regulations, relating to any of
these programs may materially adversely affect our business.

     Patents covering many brand name drugs that currently have substantial
market share will expire over the next several years,  and generic drugs will be
introduced  at prices that may  substantially  reduce the market  share of these
brand name drugs. Unlike brand name drug manufacturers, manufacturers of generic
drugs do not generally  offer  incentive  payments on their drugs to PBMs in the
form of discounts, rebates or other formulary fees. Although we expect new drugs
with  patent  protection  to be  introduced  in the  future,  we can  provide no
assurance  such drugs will capture a  significant  share of the market such that
our incentive payment revenues will not be reduced.

     Pending and Future  Litigation  Could Materially  Affect Our  Relationships
with Pharmaceutical Manufacturers or Subject Us to Significant Monetary Damages

     Since 1993, retail pharmacies have filed over 100 separate lawsuits against
drug  manufacturers,  wholesalers and certain PBMs,  challenging brand name drug
pricing practices under various state and federal antitrust laws. The plaintiffs
alleged,  among other things,  that the manufacturers  had offered,  and certain
PBMs had  knowingly  accepted,  discounts and rebates on purchases of brand name
prescription  drugs  that  violated  the  Federal  Sherman  Act and the  Federal
Robinson-Patman  Act.  Some  manufacturers  settled  certain  of these  actions,
including a Sherman Act case brought on behalf of a  nationwide  class of retail
pharmacies.  The class action settlements  generally provided for commitments by
the  manufacturers  in their  discounting  practices to retail  pharmacies.  The
Sherman  Act class  action  was  dismissed  as to these drug  manufacturers  and
wholesalers  who did not settle.  With respect to the cases filed by  plaintiffs
who opted out of the class action,  while some drug  manufacturers  have settled
certain of these actions,  such  settlements  are not part of the public record.
The Robinson-Patman Act cases are still pending.

     We are not  currently a party to any of these  proceedings.  To date, we do
not believe any of these  settlements  have had a material adverse effect on our
business.  However,  we  cannot  provide  any  assurance  that the  terms of the
settlements  will not  materially  adversely  affect us in the future or that we
will not be made a party to any separate lawsuit. In addition, we cannot predict
the outcome or possible ramifications to our business of the Robinson-Patman Act
cases.

     We are also  subject to risks  relating to  litigation  and  liability  for
damages in  connection  with our PBM  operations,  including  the  dispensing of
pharmaceutical  products  by our  mail  pharmacies,  the  services  rendered  in
connection  with our  formulary  management  and  informed  decision  counseling
services,  and our non-PBM  operations,  including  the  products  and  services
provided in connection  with our infusion  therapy  programs (and the associated
nursing  services).  We believe our  insurance  protection  is adequate  for our
present  operations.  However,  we cannot  provide any assurance that we will be
able to maintain our professional and general  liability  insurance  coverage in
the future or that such insurance coverage will be available on acceptable terms
to cover any or all  potential  product  or  professional  liability  claims.  A
successful  product or  professional  liability claim in excess of our insurance
coverage could have a material adverse effect on our business.

Changes in State and Federal Regulations Could Restrict Our Ability to Conduct
   Our Business

     Numerous  state and federal  laws and  regulations  affect our business and
operations. The categories include, but are not necessarily limited to:

     o    health  care  fraud and abuse  laws and  regulations,  which  prohibit
          certain types of referral and other payments

     o    the Employee  Retirement Income Security Act and related  regulations,
          which regulate many health care plans

     o    proposed  comprehensive  state PBM  legislation

     o    consumer protection laws and regulations

     o    pharmacy  network access laws,  including  "any willing  provider" and
          "due  process"  legislation,  that  regulate  aspects of our  pharmacy
          network   contracts

     o    legislation imposing benefit plan design restrictions, which limit how
          our clients can design  their drug benefit  plans

     o    various   licensure  laws,  such  as  managed  care  and  third  party
          administrator  licensure  laws

     o    drug pricing legislation,  including "most favored nation" pricing and
          "unitary  pricing"  legislation

     o    mail pharmacy laws and regulations

     o    privacy and confidentiality laws and regulations

     o    Medicare  prescription  drug coverage  proposals

     o    other  Medicare and  Medicaid  reimbursement  regulations

     o    potential  regulation  of the PBM  industry by the U.S.  Food and Drug
          Administration

These and other regulatory  matters are discussed in more detail under "Business
- - Government Regulation" above.

     We believe we are operating our business in substantial compliance with
all existing legal requirements material to the operation of our business. There
are,  however,  significant  uncertainties  regarding the application of many of
these legal  requirements  to our business,  and we cannot provide any assurance
that a  regulatory  agency  charged  with  enforcement  of any of these  laws or
regulations  will not interpret them  differently or, if there is an enforcement
action brought against us, that our interpretation  would prevail.  In addition,
there are numerous  proposed health care laws and regulations at the federal and
state levels,  many of which could materially  affect our ability to conduct our
business or adversely affect our results of operations. We are unable to predict
what additional  federal or state  legislation or regulatory  initiatives may be
enacted in the future  relating to our  business or the health care  industry in
general, or what effect any such legislation or regulations might have on us.

Efforts to Reduce Health Care Costs and Alter Health Care Financing Practices
   Could Adversely Affect Our Business

     Efforts are being made in the United  States to control  health care costs,
including prescription drug costs, in response to, among other things, increases
in prescription  drug  utilization  rates and drug prices.  If these efforts are
successful  or  if  prescription   drug  utilization   rates  were  to  decrease
significantly,  our  business  and  results of  operations  could be  materially
adversely affected.

     We have  designed our business to compete  within the current  structure of
the U.S.  health  care  system.  Changing  political,  economic  and  regulatory
influences may affect health care financing and reimbursement  practices. If the
current health care financing and  reimbursement  system changes  significantly,
our  business  could be  materially  adversely  affected.  Congress is currently
considering proposals to reform the U.S. health care system. These proposals may
increase governmental involvement in health care and PBM services, and otherwise
change the way our clients do business.  Health care  organizations may react to
these  proposals and the  uncertainty  surrounding  them by reducing or delaying
purchases of cost control  mechanisms and related  services that we provide.  We
cannot predict what effect,  if any,  these  proposals may have on our business.
Other  legislative  or  market-driven  changes in the health care system that we
cannot anticipate could also materially adversely affect our business.

Loss of Key Management Could Adversely Affect Our Business

     Our success is  materially  dependent  upon  certain key  managers  and, in
particular,  upon the continued  services of Barrett A. Toan,  our President and
Chief Executive  Officer.  Our future  operations could be materially  adversely
affected if the services of Mr. Toan cease to be  available.  We are party to an
employment  agreement  with Mr. Toan that  currently  extends to March 31, 2002.
This agreement automatically extends for an additional year on April 1, 2001 and
on each April 1 thereafter  unless either party gives notice of  termination  at
least 30 days prior to such April 1. As of the date hereof, neither Mr. Toan has
nor we have given such notice.

New York Life Insurance Company Can Control Our Business and Limit Our Ability
   to Enter Into Selected Business Transactions

     We have two classes of authorized  common  stock:  Class A Common Stock and
Class B Common Stock.  Our Class A Common Stock has been publicly  traded on The
Nasdaq  National Market since June 9, 1992. Our Class B Common Stock is entirely
owned by NYLIFE HealthCare Management,  Inc. ("NYLIFE HealthCare"),  an indirect
subsidiary of New York Life Insurance  Company ("New York Life").  Each share of
our Class A Common  Stock has one vote per share,  and each share of our Class B
Common stock has ten votes per share.  Consequently,  although NYLIFE HealthCare
currently  owns  approximately  39% of our  total  outstanding  shares of Common
Stock,  it  possesses  approximately  86% of the  combined  voting power of both
classes of Common Stock. NYLIFE HealthCare could reduce its Class B Common Stock
ownership to represent slightly less than 10% of the total outstanding shares of
our common stock and still  control a majority of the voting power of our common
stock.  Accordingly,  without  regard to the votes of our  public  stockholders,
NYLIFE HealthCare can

     o    elect or  remove  all of our  directors

     o    amend our  certificate  of  incorporation,  except  where the separate
          approval of the holders of our Class A Common Stock is required by law

     o    accept  or reject a merger,  sale of assets or other  major  corporate
          transaction

     o    accept or reject any  proposed  acquisition  of ours

     o    determine  the  amount  and  timing of  dividends  paid to itself  and
          holders of our Class A Common Stock

     o    except in limited circumstances,  otherwise control our management and
          operations and decide all matters submitted for a stockholder vote

     Our Class B common stock will automatically convert into the same number of
shares of our Class A common  stock upon  transfer by NYLIFE  HealthCare  to any
entity  other than an  affiliate  of New York Life or otherwise at the option of
NYLIFE HealthCare.  We cannot assure you, however, that our Class B common stock
would automatically  convert into our Class A common stock if New York Life were
to transfer the stock of NYLIFE HealthCare to someone who is not an affiliate of
New York Life.

Item 2 - Properties

     We operate our United States and Canadian PBM and non-PBM businesses out of
leased and owned facilities  throughout the United States and Canada. All of our
facilities are leased except for our Albuquerque,  New Mexico facility, which we
own.

          PBM Facilities                             Non-PBM Facilities
    Maryland Heights, Missouri                   Maryland Heights, Missouri
       Earth City, Missouri                         Earth City, Missouri
          Tempe, Arizona                             Columbia, Missouri
      Bloomington, Minnesota                           Dallas, Texas
       Plymouth, Minnesota                             Houston, Texas
      Bensalem, Pennsylvania                         Columbia, Maryland
          Troy, New York                               Tempe, Arizona
    Farmington Hills, Michigan                    Springfield, New Jersey
     Albuquerque, New Mexico                     West Chester, Pennsylvania
      Horsham, Pennsylvania
       Mississauga, Ontario

     Our Maryland  Heights,  Missouri  facility  houses our  corporate  offices.
Express Scripts Infusion Services and Specialty  Distribution Services corporate
offices  are also  located  at our  Maryland  Heights,  Missouri  facility.  Our
Specialty  Distribution  services  are  operated  out of our  facility in Tempe,
Arizona and a separate  facility in Maryland Heights,  Missouri.  We believe our
facilities  have  been  generally  well  maintained  and are in  good  operating
condition.  Our existing facilities contain approximately  1,100,000 square feet
in area, in the aggregate.

     We own computer systems for both the Maryland Heights,  Missouri and Tempe,
Arizona  sites.  In late 1999, we entered into a five year agreement with EDS to
outsource  our IS  operations.  Under  the  terms  of  the  agreement,  EDS  has
responsibility for operating and maintaining the computer systems.  Our software
for drug utilization review and other products has been developed  internally by
us or purchased  under  perpetual,  nonexclusive  license  agreements with third
parties. Our computer systems at each site are extensively  integrated and share
common files  through local and wide area  networks.  An  uninterruptable  power
supply and diesel  generator  allow our  computers,  telephone  systems and mail
pharmacy at each site to continue to function during a power outage.  To protect
against  loss of data and extended  downtime,  we store  software and  redundant
files at both  on-site  and  off-site  facilities  on a  regular  basis and have
contingency operation plans in place. We cannot, however,  provide any assurance
that our  contingency or disaster  recovery plans would  adequately  address all
relevant issues.

Item 3 - Legal Proceedings

     As discussed in detail in our Quarterly  Report on Form 10-Q for the period
ended June 30, 1998, filed with the Securities and Exchange Commission on August
13, 1998 (the "Second Quarter,  1998 10-Q"),  we acquired all of the outstanding
capital stock of Value Health,  Inc., a Delaware  corporation  ("Value Health"),
and Managed  Prescription  Network,  Inc., a Delaware  corporation  ("MPN") from
Columbia HCA/HealthCare  Corporation ("Columbia") and its affiliates on April 1,
1998  (the   "Acquisition").   Value  Health,   MPN  and/or  their  subsidiaries
(collectively,   the   "Acquired   Entities"),   were  party  to  various  legal
proceedings, investigations or claims at the time of the Acquisition. The effect
of these  actions on our future  financial  results is not subject to reasonable
estimation   because   considerable   uncertainty  exists  about  the  outcomes.
Nevertheless,  in the opinion of management,  the ultimate liabilities resulting
from  any such  lawsuits,  investigations  or  claims  now  pending  should  not
materially affect our consolidated financial position,  results of operations or
cash flows. A brief description of the most notable of the proceedings follows:

     Bash, et al. v. Value Health,  Inc., et al., No. 3:97cv2711  (JCH)(D.Conn.)
("Bash"). On December 15, 1995, a purported shareholder class action lawsuit was
filed by Irwin Bash and Leykin,  Hyman & Bash  Associates  in the United  States
District  Court  for  the  District  of  New  Mexico  against  Diagnostek,  Inc.
("Diagnostek"),  Nunzio P. DeSantis,  William Baron,  and Courtland  Miller (all
former Diagnostek officers).  Also named as defendants in Bash are Value Health,
Inc. ("Value  Health"),  Robert E. Patricelli,  William J. McBride and Steven J.
Shulman (certain of Value Health's former officers).  The Bash Complaint asserts
that  Value  Health  and  certain  other  defendants  made  false or  misleading
statements  to the public in  connection  with  Value  Health's  acquisition  of
Diagnostek in 1995, and that  Diagnostek and certain of its former  officers and
directors made false or misleading statements concerning its financial condition
prior to the  acquisition  of Value Health.  The Bash  Complaint  asserts claims
under the  Securities  Act of 1933 and the  Securities  Exchange Act of 1934, as
well as common law claims, and seeks  certification of a class consisting of all
persons  (with  certain  exclusions)  who  purchased or  otherwise  acquired (a)
Diagnostek  common stock from March 27, 1994  through  July 28, 1995;  (b) Value
Health common stock pursuant to a Proxy and Prospectus and merger in which their
Diagnostek shares were converted into Value Health shares;  and (c) Value Health
common stock from March 27, 1995 through  November 7, 1995.  The Bash  Complaint
does not specify the amount of damages  sought.  On March 26,  1996,  the former
Diagnostek  officers filed a motion  seeking  either  dismissal of the case or a
transfer to the District of Connecticut, where the earlier-filed Freedman action
(discussed  below) was pending.  In the late summer of 1997, the Bash plaintiffs
filed an Amended  Complaint that deleted those  allegations that overlapped with
the  allegations  contained in an earlier  lawsuit filed against  Diagnostek and
certain of its former officers.  A formal order approving the settlement of this
earlier lawsuit was entered by the United States District Court for the District
of New Mexico on November 21,  1997.  In  addition,  defendants  filed a renewed
motion to transfer the action to Connecticut. On October 24, 1997, an answer was
filed on  behalf of Value  Health,  Diagnostek,  and the  former  directors  and
officers of Value Health who had been named as defendants. On November 28, 1997,
the New Mexico court entered an order transferring the action to Connecticut. On
February 4, 1998,  the court  ordered that  plaintiffs  in the Freedman  action,
discussed  below,  share all discovery  obtained from the  defendants  and third
parties in their lawsuit with the  plaintiffs in the Bash lawsuit.  On March 17,
1998,  the  defendants  filed a motion  to  consolidate  this  lawsuit  with the
Freedman lawsuit  discussed below, and the court granted the motion on April 24,
1998.

     Freedman,  et al.  v.  Value  Health,  Inc.,  et  al.,  No.  3:95  CV  2038
(JCH)(D.Conn).  On September 22 and 25, 1995,  two related  lawsuits  were filed
against Value Health and certain other  defendants in the United States District
Court  for the  District  of  Connecticut.  On  February  16,  1996,  a  single,
consolidated class action complaint was filed covering both suits (the "Freedman
Complaint"), naming as defendants Value Health, Robert E. Patricelli, William J.
McBride,  Steven J.  Shulman,  David M. Wurzer,  David J.  McDonnell,  Walter J.
McNerny,  Rodman W. Moorhead,  III, Constance P. Newman, and John L. Vogelstein,
all former Value Health  directors and  officers,  and Nunzio P.  DeSantis,  the
former president of Diagnostek. The Freedman Complaint alleges that Value Health
and certain other  defendants made false or misleading  statements to the public
in  connection  with Value  Health's  acquisition  of  Diagnostek  in 1995.  The
Freedman  Complaint  asserts  claims  under the  Securities  Act of 1933 and the
Securities  Exchange Act of 1934, and seeks  certification of a class consisting
of all persons (with certain  exceptions)  who purchased  shares of Value Health
common  stock  during  the  period  March 27,  1995 (the  date  certain  adverse
developments  were disclosed by Value Health).  The Freedman  Complaint does not
specify the amount of damages sought.  On March 17, 1998, the defendants filed a
motion to consolidate  this lawsuit with the Bash lawsuit,  discussed above, and
the motion was granted on April 24, 1998.

     In the consolidated Bash and Freedman action, the court granted plaintiffs'
motions for class  certification  and  certified a class  consisting  of (i) all
persons who  purchased or otherwise  acquired  shares of Value Health during the
period from April 3, 1995,  through and  including  November 7, 1995,  including
those who acquired shares in connection with the Diagnostek merger; and (ii) all
persons who  purchased or otherwise  acquired  shares of  Diagnostek  during the
period from March 27, 1995,  through and including July 28, 1995. Fact discovery
in the  consolidated  lawsuit is complete.  The parties are awaiting an order on
motions to dismiss  portions of the Bash  plaintiffs'  second amended  complaint
filed against Diagnostek and its former officers.  The parties are also awaiting
an order  from the  court  regarding  the  scheduling  of expert  discovery  and
dispositive motions.

     In connection with the Acquisition,  Columbia has agreed to defend and hold
the  Company and its  affiliates  (including  Value  Health)  harmless  from and
against any liability that may arise in connection  with either of the foregoing
proceedings.  Consequently,  the  Company  does not  believe  it will  incur any
material liability in connection with the foregoing matters.

     As discussed in the Company's  Quarterly Report on Form 10-Q for the period
ended June 30, 1999, filed with the Securities and Exchange Commission on August
12,  1999,  the Company was named as a defendant in a patent  infringement  suit
entitled Allcare Health Management Systems,  Inc. v. Cerner Corporation,  et al.
No.  499-CV-0464-Y  (N.D.  TX). On February 17, 2000,  the Company  settled this
matter by  obtaining a release  from  Plaintiff  for all claims  asserted in the
lawsuit  in  exchange  for  payment  of an amount  that is not  material  to the
Company's financial results.

     In addition,  in the  ordinary  course of our  business,  there have arisen
various  legal  proceedings,  investigations  or claims now pending  against our
subsidiaries unrelated to the Acquisition and us. The effect of these actions on
future  financial  results  is not  subject  to  reasonable  estimation  because
considerable uncertainty exists about the outcomes. Nevertheless, in the opinion
of  management,  the  ultimate  liabilities  resulting  from any such  lawsuits,
investigations or claims now pending will not materially affect our consolidated
financial position, results of operations or cash flows.

     Since 1993, retail pharmacies have filed over 100 separate lawsuits against
drug  manufacturers,  wholesalers and certain PBMs,  challenging brand name drug
pricing practices under various state and federal antitrust laws. The plaintiffs
alleged,  among other things,  that the manufacturers  had offered,  and certain
PBMs had  knowingly  accepted,  discounts and rebates on purchases of brand name
prescription  drugs  that  violated  the  federal   Robinson-Patman   Act.  Some
plaintiffs also filed claims against the drug manufacturers and drug wholesalers
alleging a  conspiracy  not to discount  pharmaceutical  drugs in  violation  of
Section 1 of the Sherman Act, and these claims were certified as a class action.
Some of the drug  manufacturers  settled  both the Sherman Act and the  Robinson
Patman claims against them. The class action Sherman Act  settlements  generally
provide that the  manufacturers  will not refuse to pay  discounts or rebates to
retail pharmacies based on their status as such. Settlements with plaintiffs who
opted out of the class are not part of the public record.  The drug manufacturer
and  wholesaler  defendants in the class action who did not settle went to trial
and were dismissed by the court on a motion for directed verdict. That dismissal
was affirmed by the Court of Appeals for the Seventh Circuit.  One aspect of the
case was remanded to the trial court and has now been dismissed.  Plaintiffs who
opted out of the class  action  will  still  have the  opportunity  to try their
Sherman Act claims in separate  lawsuits.  The class  action did not involve the
Robinson-Patman claims, so many of those matters are still pending. We are not a
party to any of these  proceedings.  To date, we do not believe any  settlements
have had a material adverse effect on our business.  However,  we cannot provide
any assurance that the terms of the  settlements  will not materially  adversely
affect us in the future. In addition,  we cannot predict the outcome or possible
ramifications  to our business of the cases in which the  plaintiffs  are trying
their claims separately, and we cannot provide any assurance that we will not be
made a party to any such separate lawsuits in the future.


Item 4 - Submission of Matters to a Vote of Security Holders

     No matters were  submitted to a vote of security  holders during the fourth
quarter of 1999.


                                     PART II


Item 5 - Market For Registrant's Common Equity and Related Stockholder Matters

     Market Price of and Dividends on the Registrant's Common Equity and Related
Stockholder Matters

     Market  Information.  Our  Class A Common  Stock is  traded  on the  Nasdaq
National  Market  ("Nasdaq")  tier of The Nasdaq  Stock  Market under the symbol
"ESRX".  The high and low prices, as reported by the Nasdaq, are set forth below
for the periods indicated. These prices reflect the two-for-one split on October
30, 1998,  in the form of a 100% stock  dividend to holders of record on October
20, 1998.

<TABLE>
<CAPTION>
                                Fiscal Year 1999            Fiscal Year 1998
Class A Common Stock           High          Low           High           Low
<S>                        <C>           <C>           <C>           <C>
     First Quarter         $  105.500    $   59.125    $   42.750    $   27.000
     Second Quarter            91.000        55.000        45.000        35.500
     Third Quarter             92.375        61.500        45.250        31.625
     Fourth Quarter            88.688        44.375        69.000        33.875
</TABLE>

     Our Class B Common Stock has no  established  public  trading  market,  but
those shares will  automatically  convert to Class A Common Stock on a share for
share  basis  upon  transfer  thereof  to any  entity  other  than New York Life
Insurance Company or one of its affiliates.

     Holders.  As of February 29, 2000, there were 258 stockholders of record of
our Class A Common Stock,  and one holder of record of our Class B Common Stock.
We estimate  there are  approximately  21,000  beneficial  owners of the Class A
Common Stock.

     Dividends.  The Board of Directors  has not declared any cash  dividends on
our common stock since the initial public offering.  The Board of Directors does
not currently  intend to declare any cash dividends in the  foreseeable  future.
The terms of our existing credit facility  contains certain  restrictions on our
ability to declare or pay cash dividends.

     Recent Sales of Unregistered Securities

         None.

Item 6 - Selected Financial Data

The following  selected  financial data should be read in  conjunction  with the
Consolidated  Financial  Statements,  including the related  notes,  and "Item 7
- --Management's  Discussion  and Analysis of Financial  Condition  and Results of
Operations".

<TABLE>
<CAPTION>
                                                                        Year Ended December 31,

(in thousands, except per share data)             1999(2)        1998(3)         1997           1996           1995
<S>                                             <C>            <C>            <C>            <C>            <C>
- ------------------------------------------------------------------------------------------------------------------------
Statement of Operations Data:
Revenues:
   Revenues                                     $ 4,285,104    $ 2,824,872    $ 1,230,634    $   773,615    $   544,460
   Other revenues                                     3,000              -              -              -              -
                                               -------------- -------------- -------------- -------------- --------------
                                                  4,288,104      2,824,872      1,230,634        773,615        544,460
                                               -------------- -------------- -------------- -------------- --------------
Costs and expenses:
   Cost of revenues                               3,826,905      2,584,997      1,119,167        684,882        478,283
   Selling, general and administrative              294,194        148,990         62,617         49,103         37,300
   Non-recurring charges                             30,221          1,651              -              -              -
                                               -------------- -------------- -------------- -------------- --------------
                                                  4,151,320      2,735,638      1,181,784        733,985        515,583
                                               -------------- -------------- -------------- -------------- --------------
Operating income                                    136,784         89,234         48,850         39,630         28,877
Other income (expense), net                         128,682        (12,994)         5,856          3,450            757
                                               -------------- -------------- -------------- -------------- --------------
Income before income taxes                          265,466         76,240         54,706         43,080         29,634
Provision for income taxes                          108,098         33,566         21,277         16,932         11,307
                                               -------------- -------------- -------------- -------------- --------------
Income before extraordinary items                   157,368         42,674         33,429         26,148         18,327
Extraordinary loss on early retirement of             7,150              -              -              -              -
debt
                                               ============== ============== ============== ============== ==============
Net income                                      $   150,218    $    42,674    $    33,429    $    26,148    $    18,327
                                               ============== ============== ============== ============== ==============

Basic earnings per share(1)
  Before extraordinary item                     $      4.36    $      1.29    $      1.02    $      0.81    $      0.62
  Extraordinary loss on early retirement of            0.20              -              -              -              -
debt
                                               ============== ============== ============== ============== ==============
  Net income                                    $      4.16    $      1.29    $      1.02    $      0.81    $      0.62
                                               ============== ============== ============== ============== ==============

Diluted earnings per share(1)
  Before extraordinary item                     $      4.25    $      1.27    $      1.01    $      0.80    $      0.60
  Extraordinary loss on early retirement of            0.19              -              -              -              -
debt
                                               ============== ============== ============== ============== ==============
  Net income                                    $      4.06    $      1.27    $      1.01    $      0.80    $      0.60
                                               ============== ============== ============== ============== ==============

Weighted average shares outstanding(1)
   Basic                                             36,095         33,105         32,713         32,160         29,560
   Diluted                                           37,033         33,698         33,122         32,700         30,545

- -------------------------------------------------------------------------------------------------------------------------
Balance Sheet Data:
Cash                                            $   132,630    $   122,589    $    64,155    $    25,211    $    11,506
Working capital                                     (34,003)       117,611        166,062        128,259         58,653
Total assets                                      2,487,311      1,095,461        402,508        300,425        164,088
Debt:
   Short-term debt                                        -         54,000              -              -              -
   Long-term debt                                   635,873        306,000              -              -              -
Stockholders' equity                                699,482        249,694        203,701        164,090         77,379

- -------------------------------------------------------------------------------------------------------------------------
Selected Data:
Pharmacy benefit covered lives(4)                    49,000         23,000         13,000         10,000          8,000
Annual drug spending(5)                         $11,160,000    $ 4,495,000    $ 2,486,000    $ 1,636,000    $ 1,172,000
Pharmacy network claims processed                   273,909        113,177         73,164         57,838         42,871
Mail pharmacy prescriptions filled                   10,608          7,426          3,899          2,770          2,129
EBITDA(6)                                       $   208,651    $   115,683    $    59,320    $    46,337    $    33,258
Cash flows provided by operating activities     $   214,059    $   126,574    $    52,391    $    29,863    $    11,500
Cash flows used in investing activities         $  (759,576)   $  (426,052)   $   (16,455)   $   (64,808)   $    (8,047)
Cash flows provided by financing activities     $   555,450    $   357,959    $     3,033    $    48,652    $     2,311
- ------------------------------------------------------------------------------------------------------------------------
<FN>

(1) Earnings  per  share  and  weighted  average  shares  outstanding  have been
    restated to reflect the two-for-one stock split effective October 30, 1998.
(2) Includes the  acquisition  of DPS  effective  April 1, 1999.  Also  includes
    non-recurring operating charges and a one-time non operating gain of $30,221
    ($18,188  after  tax)  and  $182,930  ($112,037  after  tax),  respectively.
    Excluding  these  amounts,  our basic and diluted  earnings per share before
    extraordinary loss would have been $1.76 and $1.72, respectively.
(3) Includes the acquisition of ValueRx effective April 1, 1998. Also includes a
    non-recurring  charge of $1,651  ($1,002 after tax).  Excluding this charge,
    our basic and  diluted  earnings  per share would have been $1.32 and $1.30,
    respectively.
(4) Does not  reflect  the  addition  or loss of members to arrive at January 1,
    2000, 1999, 1998, 1997 or 1996  membership.  Although our membership  counts
    are based on  eligibility  data  provided by our clients,  they  necessarily
    involve some estimates,  extrapolations and approximations.  As one example,
    some plan designs allow for family  coverage  under a single  identification
    number,  and we make  assumptions  about the  average  number of persons per
    family in calculating  the membership  covered by such plans.  Because these
    assumptions may vary between PBMs,  membership  counts may not be comparable
    between our  competitors and us.  However,  we believe our membership  count
    provides a reasonable estimation of the population we serve, and can be used
    as one measure of our growth.
(5) Annual drug  spending is a measure of the gross  aggregate  dollar  value of
    drug expenditures of all programs we manage.  The difference  between annual
    drug spending and revenue  reported is the combined effect of excluding from
    reported revenues:  (i) the drug ingredient cost for those clients that have
    established their own pharmacy networks; (ii) the expenditures for drugs for
    companies on formulary-only programs we manage; and (iii) the co-pay portion
    of drug expenditures that are the  responsibility of members of health plans
    we service.  Therefore,  annual  drug  spending  provides a common  basis to
    compare the drug  expenditures  managed by a company  given  differences  in
    revenue  recognition.  Drug spend,  however,  is not an  accepted  reporting
    measurement under generally accepted accounting principles and should not be
    considered as an alternative to revenue.
(6) EBITDA is earnings before  interest,  taxes,  depreciation  and amortization
    (operating income plus depreciation and  amortization).  EBITDA is presented
    because it is a widely  accepted  indicator of a company's  ability to incur
    and service indebtedness.  EBITDA,  however,  should not be considered as an
    alternative  to net income,  as a measure of  operating  performance,  as an
    alternative  to cash flow or as a measure of  liquidity.  In  addition,  our
    EBITDA  definition  may not be  comparable to similar  measures  reported by
    other companies.
</FN>
</TABLE>

Item 7 - Management's Discussion and Analysis of Financial Condition and Results
         of Operations

OVERVIEW

     On April 1, 1999,  we completed our second major  acquisition  by acquiring
Diversified   Pharmaceutical  Services,  Inc.  and  Diversified   Pharmaceutical
Services  (Puerto Rico) Inc.  (collectively,  "DPS"),  from  SmithKline  Beecham
Corporation  ("SmithKline  Beecham") and SmithKline  Beecham  InterCredit BV for
approximately  $715 million,  which  includes a purchase  price  adjustment  for
closing working capital and transaction  costs. On April 1, 1998, we consummated
our first  major  acquisition  by  acquiring  Value  Health,  Inc.  and  Managed
Prescription  Network,  Inc.  (collectively,  "ValueRx"),  the pharmacy  benefit
management   ("PBM")   operations   of   Columbia/HCA   Healthcare   Corporation
("Columbia"), for approximately $460 million in cash, which includes transaction
costs and executive management severance costs of approximately $6.7 million and
$8.3 million, respectively. Consequently, our operating results include those of
DPS from April 1, 1999 and ValueRx from April 1, 1998.  The net assets  acquired
from  DPS have  been  preliminarily  recorded  at their  estimated  fair  value,
resulting in $734,485,000 of goodwill that is being amortized over 30 years. The
net assets  acquired  from ValueRx have been  recorded at their  estimated  fair
value,  resulting in  $278,113,000  of goodwill that is being  amortized over 30
years.  Both  acquisitions  have been accounted for under the purchase method of
accounting.

     Reflecting the addition of new plans at January 1, 2000, our membership was
approximately 38.5 million members,  excluding approximately 9.5 million members
of health plans of United HealthCare Corp. ("UHC") whose contract expires in May
2000,  compared  to  approximately  23.5  million  lives as of  January 1, 1999,
representing  a 63.8%  increase.  The increase from January 1, 1999 is primarily
due to our acquisition of DPS. This acquisition, as well as the addition of Blue
Cross and Blue  Shield of  Massachusetts  and Blue  Shield  of  California,  has
provided us with one of the largest  managed care  membership  bases of any PBM.
Additionally,  during  1999,  we were  able to sell  additional  services  to an
existing 4.5 million members in the form of advanced formulary management or the
addition  of mail or network  service  where only one or the other had been used
previously.  This enables us to generate  higher  profitability  per claim as we
continue to cross-sell our services to existing  clients.  In 1998, we increased
membership by approximately 11.2 million members from 12.3 million members as of
January 1, 1998,  representing a 91.1%  increase.  The increase in membership in
1998 was primarily due to the purchase of ValueRx on April 1, 1998. Although our
membership  counts are based on eligibility  data provided by our clients,  they
necessarily involve some estimates,  extrapolations and  approximations.  As one
example,   some  plan  designs  allow  for  family   coverage   under  a  single
identification  number,  and we make  assumptions  about the  average  number of
persons per family in calculating the membership covered by such plans.  Because
these assumptions may vary between PBMs, membership counts may not be comparable
between  our  competitors  and us.  However,  we believe  our  membership  count
provides a reasonable  estimation of the population we serve, and can be used as
one measure of our growth.

     We derive  our  revenues  primarily  from the sale of PBM  services  in the
United  States and Canada.  Our PBM revenues  generally  include  administrative
fees,  dispensing fees and ingredient  costs of  pharmaceuticals  dispensed from
retail  pharmacies  included  in one of our  networks  or from  one of our  mail
pharmacies,  and the  associated  costs are  recorded in cost of  revenues  (the
"Gross Basis").  Where we only administer the contracts  between our clients and
the clients' retail pharmacy  networks,  as is the case for most of the customer
contracts with DPS, we record as revenues only the administrative fee we receive
from our activities (the "Net Basis"). We also derive PBM revenues from the sale
of informed  decision  counseling  services  through our Express  Health  LineSM
division, and the sale of medical information management services (which include
the development of data  warehouses to combine  medical claims and  prescription
drug  claims),  disease  management  support  services  and quality and outcomes
assessments through our Health Management Services ("HMS") division and Practice
Patterns Science, Inc. ("PPS") subsidiary.

     Non-PBM revenues are derived from:

     o    The sale of pharmaceuticals  for and the provision of infusion therapy
          services through our Express Scripts Infusion Services subsidiary

     o    Administrative   fees  received  from  drug   manufacturers   for  the
          dispensing  or  distribution  of  pharmaceuticals   requiring  special
          handling  or   packaging   through  our  Express   Scripts   Specialty
          Distribution Services subsidiary


RESULTS OF OPERATIONS

<TABLE>
<CAPTION>

REVENUES
                                                        Year Ended December 31,
(in thousands)                         1999        Increase       1998        Increase        1997
<S>                             <C>                 <C>    <C>                 <C>     <C>
- -----------------------------------------------------------------------------------------------------
PBM Gross Basis revenues        $    4,007,077      46.1%  $    2,742,485      134.6%  $   1,168,922
PBM Net Basis revenues                 212,217     837.9%          22,626        1.7%         22,251
Other revenues                           3,000         nm               -          nm              -
                               ----------------------------------------------------------------------
  Total PBM revenues            $    4,222,294      52.7%  $    2,765,111      132.1%  $   1,191,173
  Non-PBM revenues                      65,810      10.1%          59,761       51.4%         39,461
                               ======================================================================
    Total revenues              $    4,288,104      51.8%  $    2,824,872      129.5%  $   1,230,634
                               ======================================================================
</TABLE>

     Our growth in PBM revenues  during 1999 over 1998 is  primarily  due to the
inclusion  of ValueRx for the full twelve  months of 1999  compared to only nine
months of 1998, the inclusion of DPS for nine months of 1999,  increased  member
utilization and higher drug ingredient  costs resulting from price increases for
existing  drugs,  new drugs  introduced  into the  marketplace  and  changes  in
therapeutic mix and dosage.  Our growth in PBM revenues during 1998 over 1997 is
primarily due to the inclusion of ValueRx,  higher drug  ingredient  costs,  and
mail utilization.

     Revenues for network pharmacy claims increased $1,039,588,000, or 51.8%, in
1999  over 1998 and  $1,175,659,000,  or  141.7%,  in 1998  over  1997.  Network
pharmacy claims processed increased 142.0% to 273,909,000 in 1999 over 1998. The
average  revenue per network  pharmacy claim decreased 37.2% from 1998 primarily
due to the  acquisition  of DPS, as DPS  records  revenue on the Net Basis which
substantially reduces the average revenue per network pharmacy claim.  Excluding
DPS, the average  revenue per network  pharmacy claim  increased 8.2% over 1998.
During 1998,  network pharmacy claims  processed  increased 54.7% to 113,177,000
over 1997. The average  revenue per network  pharmacy claim  increased  56.3% in
1998 from 1997  primarily due to a higher  percentage of clients'  revenue being
reported on the Gross Basis compared to the Net Basis.

     Revenues for mail pharmacy services  increased  $389,244,000,  or 52.8%, in
1999 over 1998 and  $385,149,000,  or 109.6%, in 1998 over 1997. These increases
are the  result of the  growth in mail  pharmacy  claims  processed  of 42.8% to
10,608,000  in 1999 over 1998 and 90.5% to  7,426,000  in 1998 over 1997.  These
increases are primarily due to the  acquisitions  of ValueRx and DPS,  increased
utilization  by existing  members as well as the  addition of new  members.  The
average  revenue per mail pharmacy  claim  increased  7.0% in 1999 over 1998 and
10.0% in 1998 over 1997 primarily due to higher drug ingredient  costs as stated
above.

     The increase in revenue for non-PBM  services in 1999 and 1998 is primarily
due to additional business within our Specialty Distribution Services subsidiary
and continued  changes in the product mix sold in our Infusion Services business
that resulted in higher drug  ingredient  costs.  These increases were partially
offset by the reduction in revenues from our managed vision  business due to the
restructuring of this operation during 1998.

<TABLE>
<CAPTION>

COST AND EXPENSES
                                                               Year Ended December 31,
(in thousands)                               1999        Increase       1998        Increase        1997
<S>                                      <C>                 <C>    <C>                 <C>     <C>
- --------------------------------------------------------------------------------------------------------------
    PBM                                  $    3,774,618      48.6%  $    2,540,360      133.4%  $   1,088,225
         Percentage of total PBM                  89.4%                      91.9%                      91.4%
             revenues
    Non-PBM                                      52,287      17.1%          44,637       44.3%         30,942
         Percentage of non-PBM revenues           79.5%                      74.7%                      78.4%
                                        ----------------------------------------------------------------------
   Cost of revenues                           3,826,905      48.0%       2,584,997      131.0%      1,119,167
        Percentage of total revenues              89.2%                      91.5%                      90.9%

   Selling, general and administrative          231,543      78.0%         130,116      127.2%         57,257
        Percentage of total revenues               5.4%                       4.6%                       4.7%

   Depreciation and amortization(1)              62,651     231.9%          18,874      252.1%          5,360
        Percentage of total revenues               1.5%                       0.7%                       0.4%

   Non-recurring expenses                        30,221   1,730.5%           1,651          nm              -
       Percentage of total revenues                0.7%                       0.0%                       0.0%

                                        ======================================================================
   Total cost and expenses               $    4,151,320      51.7%  $    2,735,638      131.5%  $   1,181,784
                                        ======================================================================
       Percentage of total revenues               96.8%                      96.8%                      96.0%
<FN>

     (1)  Represents  depreciation and amortization expense included in selling,
          general and  administrative  expenses on our Statement of  Operations.
          Cost of revenues,  above, also includes  depreciation and amortization
          expense on property and equipment of $9,216, $7,575 and $4,998 for the
          year ended 1999, 1998 and 1997, respectively.
</FN>
</TABLE>

nm = not meaningful

     Our cost of revenues for PBM services as a percentage of total PBM revenues
decreased  in 1999 from 1998  primarily  due to the  acquisition  of DPS, as DPS
records  revenues under the Net Basis.  In future  periods,  we expect the gross
margin percentage will be somewhat higher than in prior periods until we convert
DPS clients to our pharmacy networks.  As this conversion occurs, we will record
revenues for  converted  clients on the Gross Basis and we  anticipate  that the
gross margin  percentage will then begin to decline,  although  profitability is
not expected to be adversely affected by these changes. Excluding DPS, the gross
margin  percentage  for the year ended  December 31, 1999 decreased to 7.4% from
8.1% for the year ended  December  31, 1998.  The  decrease is primarily  due to
lower drug ingredient  margins  resulting from changes in therapeutic mix, lower
pricing  offered to clients and increased  revenue  sharing  offset by improving
margins from our HMS business.  The gross margin  percentage  in 1998  decreased
from 1997  primarily due to a shift toward our  established  pharmacy  networks,
lower pricing offered to clients and increased  revenue sharing.  Prior to 1998,
we had been experiencing this trend and the acquisition of ValueRx continued the
trend as ValueRx  clients  primarily used ValueRx  established  retail  pharmacy
networks.   Partially  offsetting  the  gross  margin  decrease  were  operating
efficiencies  achieved in our mail pharmacies during 1998 and revenues generated
from integrated PBM services, such as medical drug analysis, that provide higher
gross margins.

     Cost of revenues for non-PBM services  increased as a percentage of non-PBM
revenues over 1998  primarily  due to the continued  change in product mix sold,
resulting in additional costs of approximately  $2,141,000. In addition, cost of
revenues from our Specialty  Distribution Services division increased 88.9% over
1998 as a result of  establishing a new facility to support a larger  operation.
Cost of revenue as a percentage of revenue in 1998 decreased from 1997 primarily
due to the inclusion of Specialty Distribution  Services,  which provides higher
gross  margins,  as well as improved  gross  margins from the  restructuring  of
Vision.

     Selling,  general and administrative  expenses,  excluding depreciation and
amortization,   increased   $101,427,000   or  78.0%,  in  1999  over  1998  and
$72,859,000, or 127.2%, in 1998 over 1997. The increase in 1999 is primarily due
to our  acquisition  of DPS, costs  incurred  during the  integration of DPS and
ValueRx ($8,833,000 in 1999), costs incurred in funding our Internet operations,
costs required to expand the operational and administrative support functions to
enhance  management of the pharmacy benefit,  and the inclusion of ValueRx for a
full twelve months.  The increase  during 1998 was the result of our acquisition
of ValueRx,  costs incurred  during the  integration  of ValueRx  ($8,331,000 in
1998) and costs required to expand the  operational and  administrative  support
functions to enhance  management of the pharmacy benefit.  During 1999, 1998 and
1997, we capitalized  $15,997,000  ($8,349,000 of which related to integration),
$10,244,000  ($5,209,000  of  which  related  to  integration)  and  $1,982,000,
respectively,  in new  systems  development  costs.  As a  percentage  of  total
revenues,  selling, general and administrative expenses,  excluding depreciation
and amortization, for 1999 increased to 5.4% from 4.6% in 1998 and 4.7% in 1997.
The increase in the  percentage  of revenues in 1999 is primarily  attributed to
DPS recording revenue on the Net Basis.

     Depreciation and amortization substantially increased during 1999 over 1998
and 1998 over 1997 due to the  acquisitions of DPS and ValueRx.  During 1999, we
recorded   amortization  expense  for  goodwill  and  other  intangible  assets,
excluding  deferred  financing  fees, of $53,297,000  compared to $12,183,000 in
1998.  The  remaining  increases  in 1999  were  primarily  due to  integration,
expanding our operations and enhancing our  information  systems to better serve
our clients.

     During 1999 and 1998, we incurred the following non-recurring charges:

     o    During the second quarter of 1999, we incurred a $9,400,000 charge for
          the  consolidation  of our  Plymouth,  Minnesota facility  into our
          Bloomington,  Minnesota facility.  The consolidation plan includes the
          relocation  of  all   employees  at  the  Plymouth   facility  to  the
          Bloomington facility, expected to be completed in the third quarter of
          2000. We obtained the two facilities  through  acquisitions of ValueRx
          and DPS. Included within the charge were anticipated cash expenditures
          of  approximately  $5,700,000  ($4,318,000  paid in  1999)  for  lease
          termination fees and rent on unoccupied space to be paid through April
          2001 and  anticipated  non-cash  charges of  approximately  $3,700,000
          ($2,248,000  written-off  in  1999)  for the  write-off  of  leasehold
          improvements  and furniture and fixtures.  The charge does not include
          any costs  associated  with the physical  relocation of the employees.
          During the fourth  quarter of 1999, we reduced the original  estimates
          of  non-cash  charges  by  $1,424,000  and  of  the  anticipated  cash
          expenditures  attributable to rent on the unoccupied space by $877,000
          due to the landlord renting the space sooner than we had anticipated.

     o    As a result of the integration of our acquisitions,  we entered into a
          contract  during  the  fourth  quarter  of  1999  to  consolidate  the
          operation of our computer systems with a single vendor. As a result,51
          employees were notified that their  employment was being  transitioned
          to the  outsourcer,  requiring  $332,000 in severance  payments to the
          employees.  In addition, we will incur $1,816,000 in cash expenditures
          associated  with the termination of an existing  outsourcing  contract
          and  additional  transition  payments to the  outsourcer.  We incurred
          non-cash  charges of  $485,000  related to the  impairment  of certain
          software  projects  abandoned due to the  outsourcing.  These projects
          were written off during the fourth quarter of 1999. Completion of this
          plan is  expected to occur  during the first  quarter of 2000 when all
          cash expenditures will be made.

     o    To  coordinate  our  PBM  service   offerings,   we  restructured  the
          operations  of our  PPS  subsidiary  by  transferring  the  management
          responsibility to our Health  Management  Services division during the
          fourth quarter of 1999. As a result, we incurred $133,000 in severance
          payments in December  1999 to one employee and have paid the remaining
          $277,000 in severance costs to eight employees during January 2000. In
          addition, we incurred a $559,000 charge related to our purchase of the
          Common Stock held by the management of PPS.

     o    In conjunction with the sale of the assets of  YourPharmacy.com,  Inc.
          to PlanetRx.com,  Inc.  ("PlanetRx"),  we recorded a $19,520,000 stock
          compensation charge relating to former YourPharmacy.com employees. The
          amount of the charge was determined  using the initial public offering
          price of $16 per share for PlanetRx.com common stock.

     o    During the second quarter of 1998, we incurred a $1,651,000 charge for
          the restructuring of our managed vision business due to us reaching an
          agreement  with Cole Managed  Vision  ("Cole"),  a subsidiary  of Cole
          National Corporation,  to provide certain vision care services for our
          clients  and their  members.  The  charge  consisted  of a  $1,235,000
          write-down  in fixed  assets and  $416,000  for the  transition  of 61
          employees and was completed during the third quarter of 1999.

OTHER INCOME (EXPENSE), NET

     During 1999, we recognized a one-time gain of  $182,930,000  related to the
sale of the assets of  YourPharmacy.com,  Inc. in exchange for a 19.9% ownership
interest in PlanetRx.  This one-time gain was partially offset by a $39,780,000,
or 196.6%,  increase in interest  expense  resulting  from the debt  incurred to
purchase DPS (see  "--Liquidity  and Capital  Resources").  Interest expense was
significantly  higher  in 1998  over 1997 due to the  financing  of the  ValueRx
acquisition  with $360 million of borrowed funds (see  "--Liquidity  and Capital
Resources").

     Interest income in 1999 decreased from 1998 due to using our available cash
to purchase DPS and for  repayment of debt.  The increase in interest  income in
1998 over 1997 is due to investing larger cash balances.

PROVISION FOR INCOME TAXES

     Our effective tax rate for continuing operations decreased to 40.7% in 1999
from 44.0% in 1998  primarily  due to a higher  income  before  income  taxes to
offset the non-deductible  goodwill and customer contract  amortization  expense
associated  with the ValueRx  acquisition.  The goodwill  and customer  contract
amortization  for the DPS  acquisition is deductible for income tax purposes due
to the filing of an Internal Revenue Code ss.338(h)(10)  election. The effective
tax rate  increased  to  44.0%  in 1998  from  38.9%  in 1997  primarily  due to
non-deductible  goodwill and customer contracts  amortization  expense resulting
from the ValueRx acquisition.

NET INCOME AND EARNINGS PER SHARE

     Our net income  increased  $107,544,000  or 252.0% in 1999 over  1998,  and
$9,245,000  or 27.7% in 1998 over 1997.  Net income for 1999 was affected due to
the following one-time items:

     o    Non-recurring  charges  discussed  in "--Cost and  Expenses"  totaling
          $30,221,000 ($18,188,000, net of tax).

     o    One-time gain of $182,930,000 ($112,037,000,  net of tax) discussed in
          "--Other Income (Expense), Net."

     o    An  extraordinary  loss on the early retirement of debt of $7,150,000,
          net of tax. The extraordinary  loss is associated with refinancing the
          debt  incurred  in  connection   with  our   acquisition  of  ValueRx,
          refinancing  the debt incurred in connection  with our  acquisition of
          DPS from the proceeds of our equity and debt offerings,  and repayment
          of the debt  from our own  cash,  as  discussed  in  "--Liquidity  and
          Capital Resources" below.

     Excluding  these  one-time  items,  net  income  for 1999  would  have been
$63,519,000,  or $1.76 per basic share and $1.72 per diluted  share  compared to
$1.32  per  basic  share and $1.30  per  diluted  share  for 1998,  excluding  a
non-recurring charge for the managed vision business of $1,651,000  ($1,002,000,
net of tax). Had our equity offering and Senior Notes offering been completed by
April 1, 1999 our net income,  excluding  the one-time  items above,  would have
been $67,326,000 or $1.81 per basic share and $1.77 per diluted share.

     Basic and diluted  weighted  average shares  outstanding for 1999 increased
9.0% and 9.9%, respectively,  over 1998. The increase for both basic and diluted
shares  outstanding is primarily  related to our offering of 5,175,000 shares of
our Class A Common Stock in June 1999.  The net  proceeds of the  offering  were
used to retire a portion of our long term debt, as discussed in "--Liquidity and
Capital Resources".

LIQUIDITY AND CAPITAL RESOURCES

     During 1999,  net cash  provided by  operations  increased  $87,485,000  to
$214,059,000 from  $126,574,000 in 1998.  Included in the increase is a one-time
increase in cash balances of $113,732,000  relating to the  reclassification  of
negative cash balances to claims and rebates payable due to the establishment of
new  banking  relations  during  1999,  which  resulted in moving  certain  cash
disbursement accounts to banks not holding our cash concentration accounts. This
increase was offset by approximately  $30,000,000 in increased inventory for our
mail pharmacies'  anticipation of potentially  higher demand due to our members'
Year 2000  concerns.  We  anticipate  reducing our inventory to its normal level
throughout  the  first  half of  2000.  Claims  and  rebates  payable  increased
$512,379,000, or 151.5%, from December 31, 1998, while net receivables increased
$350,080,000, or 80.8%, from December 31, 1998, primarily due to the acquisition
of DPS. The inclusion of DPS reduced our days sales outstanding  ("DSO") to 27.7
days at December  31, 1999 from 36.9 days at December  31, 1998 and 35.9 days at
December  31, 1997.  Gross  revenues  must be used to  calculate  the days sales
outstanding  due to the  impact  of the  Gross  Basis  versus  the Net  Basis of
recording revenues,  as discussed in "--Overview" and "--Revenues." The accounts
receivable balance includes the cost of the pharmaceutical dispensed,  which may
not be  included in  revenues,  as required  by  generally  accepted  accounting
principles,  based on the  contractual  terms  embedded  in client and  pharmacy
contracts. The following table presents our days sales outstanding for the years
ended:
<TABLE>
<CAPTION>

                                                                    December 31,
(in thousands)                               1999                       1998                        1997
<S>                                      <C>                        <C>                         <C>
- --------------------------------------------------------------------------------------------------------------
Total revenues                           $    4,288,104             $    2,824,872              $   1,230,634
Client/pharmacy pass through                  3,570,108                    726,960                    764,367
                                        ================           ================            ===============
Gross revenues                                7,858,212                  3,551,832                  1,995,001
                                        ================           ================            ===============

Average monthly gross receivables               597,160                    359,423                    196,213
                                        ================           ================            ===============

DSO                                              27.7                       36.9                        35.9
                                        ================           ================            ===============
</TABLE>

     Our  allowance  for  doubtful  accounts has  decreased  $525,000 or 2.9% to
$17,281,000  at December 31, 1999 from  $17,806,000  at December  31, 1998.  The
decrease is primarily due to the final adjustment,  in accordance with generally
accepted accounting  principles,  to the ValueRx opening balance sheet allowance
for doubtful  accounts and goodwill  based on the actual  collection  of ValueRx
receivables.

     As a percentage of at risk  receivables  (which  represent  receivables for
which there is no corresponding  payable),  the allowance for doubtful  accounts
was 2.6% at December 31, 1999  compared to 3.9% at December 31, 1998 and 2.2% at
December 31, 1997. The  percentage  reduction from December 31, 1998 to December
31, 1999 is attributable to the  aforementioned  final adjustment of the ValueRx
opening balance sheet.

     Our  investment  in  net  working  capital  decreased  significantly  to  a
$34,003,000  deficit as of December  31, 1999 from a  $117,611,000  excess as of
December 31, 1998. This reduction is directly  related to our acquisition of DPS
as, the DPS business model utilizes considerably different payment cycles.

     In fiscal 2000, we expect our cash flow from operations will be temporarily
reduced by approximately $20,000,000 during the third quarter of 2000 due to the
termination of the United HealthCare contract. Once the termination is complete,
we expect our cash flow from operations to recover to  approximately  the levels
achieved prior to the  termination.  We expect to primarily fund the termination
of the United  HealthCare  contract in 2000, our future debt service,  inventory
purchases,   integration  costs,  Internet  initiatives,  payment  of  our  1999
non-recurring  charges and other  normal  operating  cash needs  primarily  with
operating cash flow or, to the extent necessary, with working capital borrowings
under our $300 million revolving credit facility, discussed below.

     Our capital  expenditures in 1999 increased  $13,105,000 or 54.9% over 1998
primarily due to integration related activities as a result of our acquisitions,
our  concerted  effort to invest in our  information  technology  to enhance the
services   provided  to  our  clients  and  the   completion  of  our  corporate
headquarters.  We expect to continue  investing in technology  that will provide
efficiencies  in operations,  manage growth and enhance the service  provided to
our clients. We expect to fund future anticipated capital expenditures primarily
with  operating  cash flow or, to the extent  necessary,  with  working  capital
borrowings under the $300 million  revolving  credit facility,  discussed below.
The $10,948,000 increase in 1998 capital expenditures over 1997 is primarily due
to our integration of the ValueRx  operations and our concerted effort to invest
in information  technology to enhance the services  provided to our clients.  In
addition,  we invested in equipment to improve  efficiency  and manage growth at
our mail pharmacy facilities.

     In October 1999,  we  consummated  our agreement  with PlanetRx in which we
sold the  assets  constituting  our  e-commerce  business  in  prescription  and
non-prescription  drugs and health and beauty aids to PlanetRx in exchange for a
19.9% interest in the common equity of PlanetRx. As a result of the transaction,
we recorded a one-time  gain (in other  income) of  $182,930,000  and a one-time
stock compensation  expense (included in non-recurring  expenses) of $19,520,000
relating to the employee stock options. We are accounting for this investment on
the cost method and  therefore  reporting  our  investment  on the balance sheet
under the caption  "investment  in marketable  securities"  at fair market value
($150,365,000  at December 31, 1999) in  accordance  with  Financial  Accounting
Standards Board  Statement 115. As such, the associated  unrealized loss on this
investment  ($9,555,000,  net of tax,  at December  31,  1999) is  considered  a
component of comprehensive  income in the  Consolidated  Statement of Changes in
Stockholders' Equity.

     On April 1, 1999, we executed a $1.05 billion  credit  facility with a bank
syndicate led by Credit Suisse First Boston and Bankers Trust Company consisting
of $750 million in term loans,  including  $285 million of Term A loans and $465
million of Term B loans, and a $300 million  revolving  credit  facility.  As of
July 1999,  the Term B loans have been paid off  through net  proceeds  from our
equity and senior notes  offerings and $74,131,000 of our own cash. As a result,
we recorded an extraordinary loss as discussed in "--Net Income and Earnings Per
Share" above.  In January 2000, we repaid an additional $30 million  against the
revolving  credit  facility.  The Term A loans and the revolving credit facility
mature on March 31, 2005. The credit facility is secured by the capital stock of
each of our existing and subsequently acquired domestic subsidiaries,  excluding
Practice  Patterns  Science,  Great  Plains  Reinsurance,  ValueRx of  Michigan,
Diversified NY IPA and Diversified Pharmaceutical Services (Puerto Rico), and is
also secured by 65% of the stock of our foreign subsidiaries.

     The credit  facility  requires us to pay interest  quarterly on an interest
rate spread based on several London  Interbank  Offered Rates  ("LIBOR") or base
rate options.  Using a LIBOR spread, the Term A loans and the revolving loan had
an interest rate of 7.94% on December 31, 1999.  Beginning in March 2001, we are
required to make annual principal payments on the Term A loans of $42,750,000 in
2001, $57,000,000 in 2002 and 2003, $62,700,000 in 2004 and $65,550,000 in 2005.
The credit facility contains covenants that limit the indebtedness we may incur,
dividends paid and the amount of annual capital expenditures. The covenants also
establish a minimum  interest  coverage ratio, a maximum  leverage ratio,  and a
minimum  fixed charge  coverage  ratio.  In addition,  we are required to pay an
annual fee of 0.5%, payable in quarterly installments,  on the unused portion of
the revolving  credit  facility ($200 million at December 31, 1999). At December
31, 1999, we are in  compliance  with all  covenants  associated  with the $1.05
billion credit facility.

     Additionally,  on  April  1,  1999,  we  executed  a  $150  million  senior
subordinated  bridge credit facility from Credit Suisse First Boston Corporation
and Bankers Trust Company. The proceeds from the bridge credit facility and $890
million in borrowings  from the credit  facility were used to consummate the DPS
acquisition,  refinance our $440 million credit facility,  of which $360 million
was outstanding, and other indebtedness and pay related fees and expenses.


     In June 1999, we completed our equity  offering of 5,175,000  shares of our
Class A common stock at an offering  price of $61 per share.  We also  completed
our offering of $250 million 9 5/8% Senior Notes due 2009. The net proceeds from
the equity and debt offerings of $299,378,000  and  $243,503,000,  respectively,
were used to retire the $150 million senior  subordinated bridge credit facility
plus  accrued  interest  and repay a portion of the Term B portion of the credit
facility plus accrued interest.

     To alleviate  interest  rate  volatility,  we entered into an interest rate
swap  arrangement  for an original  notional  principal  amount of $360 million,
effective  April 3, 1998,  with the First  National  Bank of Chicago.  Under the
terms of the swap, we agreed to receive a floating rate of interest on a portion
of our term loans based on a three-month LIBOR rate in exchange for payment of a
fixed rate of  interest  of 5.88% per  annum.  The  notional  amount of the swap
started  amortizing in April 1999 in  semi-annual  installments  of $27 million,
increasing to $36 million in April 2000, to $45 million in April 2001 and to $48
million in April 2002. As of December 31, 1999, the notional principal amount is
$306 million.  As a result,  we have, in effect,  converted  $306 million of our
variable  rate debt  under the Credit  Facility  to fixed rate debt at 5.88% per
annum for the first four years of the Credit  Facility,  plus the interest  rate
spread of 2.0%.

     On June 17, 1999, we entered into another  interest  rate swap  arrangement
with Bankers Trust Company,  effective  April 17, 2000 and  terminating on April
17, 2005. As of December 31, 1999, there is no notional  principal amount as the
swap is not yet  effective.  Upon  effectiveness,  the swap will have an initial
notional  principal  amount of $15  million  increasing  to  $137.25  million in
October  2002.  Beginning  in April 2003,  the  notional  principal  amount will
amortize  over the remaining  term of the swap.  Under the terms of the swap, we
agreed to receive a floating rate of interest on the notional  principal  amount
based on a  three-month  LIBOR rate in  exchange  for payment of a fixed rate of
interest  of 6.25% per  annum.  When the swap  becomes  effective,  we will,  in
effect,  convert the notional  principal  amount of our variable rate debt under
our Credit Facility to fixed rate debt at 6.25% per annum.

     As of December 31, 1999, we had  repurchased  a total of 475,000  shares of
our Class A Common Stock under the open-market stock repurchase  program that we
announced on October 25, 1996,  although no shares were  repurchased  in 1999 or
1998. Our Board of Directors  approved the repurchase of up to 1,700,000 shares,
and placed no limit on the duration of the program.  Since December 31, 1999, we
have made  additional  repurchases  of 467,500  shares  through  March 23, 2000.
Additional purchases,  if any, will be made in such amounts and at such times as
we deem  appropriate  based  upon  prevailing  market and  business  conditions,
subject to  restrictions  on stock  repurchases  contained in our $1.05  billion
credit  facility  and the  Indenture  under which our Senior  Notes were issued.
During 1999, we used approximately  10,000 shares previously purchased under the
above program to satisfy obligations under our employee stock option program.

     We have  reviewed  and  currently  intend to continue  reviewing  potential
acquisitions  and  affiliation  opportunities.  We believe that  available  cash
resources,  bank  financing or the issuance of additional  common stock could be
used to finance such  acquisitions  or  affiliations.  However,  there can be no
assurance we will make other acquisitions or affiliations in 2000 or thereafter.

OTHER MATTERS

     In  June  1998,   Financial   Accounting  Standards  Board  Statement  133,
Accounting for Derivative  Instruments  and Hedging  Activities  ("FAS 133") was
issued.  FAS 133 requires all  derivatives  to be recognized as either assets or
liabilities  in the statement of financial  position and measured at fair value.
In addition, FAS 133 specifies the accounting for changes in the fair value of a
derivative  based  on the  intended  use of the  derivative  and  the  resulting
designation.  The effective  date for FAS 133 was  originally  effective for all
fiscal  quarters of fiscal years  beginning  after June 15, 1999.  However,  the
Financial  Accounting Standards Board has deferred the effective date so that it
will begin for all fiscal  quarters  of fiscal  years  beginning  after June 15,
2000,  and will be  applicable  to our first  quarter of fiscal  year 2001.  Our
present interest rate swaps (see  "--Liquidity  and Capital  Resources") will be
considered  cash flow hedges.  Accordingly,  the change in the fair value of the
swaps  will be  reported  on the  balance  sheet as an asset or  liability.  The
corresponding  unrealized  gain or loss  representing  the effective  portion of
these  hedges will be initially  recognized  in  stockholders'  equity and other
comprehensive  income and  subsequently  any changes in unrealized  gain or loss
from the initial measurement date will be recognized in earnings concurrent with
the interest expense on our underlying variable rate debt. If we had adopted FAS
133 as of December  31, 1999,  we would have  recorded  the  unrealized  gain of
$6,867,000  as  an  asset  and  increase  in  stockholders'   equity  and  other
comprehensive income.

YEAR 2000

     Our  operations  rely heavily on computers  and other  information  systems
technologies.  In 1995, we began addressing the "Year 2000" issue,  which refers
to the  inability of certain  computer  systems to properly  recognize  calendar
dates beyond  December 31, 1999.  This arises as a result of systems having been
programmed with two digits rather than four digits to define the applicable year
in  order  to  conserve  computer  storage  space,   reduce  the  complexity  of
calculations  and produce  better  performance.  The two-digit  system may cause
computers to interpret the year "00" as "1900" rather than as "2000",  which may
cause  system   failures  or  produce   incorrect   results  when  dealing  with
date-sensitive information beyond 1999.

     In addressing the Year 2000 issue,  we incurred  approximately  $4,700,000,
excluding costs incurred by DPS prior to our acquisition.  All expenditures were
expensed as incurred.  These costs did not have a material adverse effect on our
results of operations, financial condition or cash flows.

     As of the date of this filing, we have experienced no Year 2000 issues that
have materially impacted our results of operations,  financial condition or cash
flows.  We do not believe that Year 2000 issues will likely pose any significant
operational  problems for us. We have  formalized  contingency  plans should any
Year 2000 issues arise.  If,  however,  our  contingency  plans fail to properly
address  the Year 2000  issue,  the  impact  could  result in  material  adverse
operational and financial consequences to us.


IMPACT OF INFLATION

     Changes  in  prices   charged  by   manufacturers   and   wholesalers   for
pharmaceuticals  affect our revenues and cost of revenues. To date, we have been
able to  recover  price  increases  from  our  clients  under  the  terms of our
agreements,  although under selected  arrangements in which we have  performance
measurements  on drug costs with our clients we could be  adversely  affected by
inflation in drug costs if the result is an overall  increase in the cost of the
drug plan to the client. To date, changes in pharmaceutical  prices have not had
a significant adverse affect on us.


MARKET RISK

     We have entered into two interest rate swaps (see  "--Liquidity and Capital
Resources"). The fair value of the swaps at December 31, 1999 is $6,867,000.

     Interest  rate risk is  monitored on the basis of changes in the fair value
and a sensitivity analysis is used to determine the impact interest rate changes
will have on the fair value of the interest rate swaps,  measuring the change in
the net present  value  arising from the change in the interest  rate.  The fair
value of the swaps are then  determined by calculating  the present value of all
cash flows  expected  to arise  thereunder,  with  future  interest  rate levels
implied from prevailing mid-market yields for money-market instruments, interest
rate futures and/or prevailing mid-market swap rates. Anticipated cash flows are
then  discounted on the  assumption of a  continuously  compounding  zero-coupon
yield  curve.  A 10 basis point  decline in interest  rates at December 31, 1999
would have caused the fair value of the swaps to decrease by $778,000, resulting
in a fair value of $6,089,000.


Item 7A.  Quantitative and Qualitative Disclosures About Market Risk.

     Response to this item is included in Item 7  "Management's  Discussion  and
Analysis of Financial Condition and Results of Operations--Market Risk" above.

Item 8 - Consolidated Financial Statements and Supplementary Data

                        Report of Independent Accountants


To the Board of Directors and
Stockholders of Express Scripts, Inc.


In our  opinion,  the  consolidated  financial  statements  listed  in the index
appearing  under  Item  14(a)(1)  on page 64  present  fairly,  in all  material
respects,  the financial position of Express Scripts,  Inc. and its subsidiaries
at December  31, 1999 and 1998,  and the results of their  operations  and their
cash flows for each of the three years in the period ended  December 31, 1999 in
conformity with accounting  principles  generally accepted in the United States.
In addition,  in our opinion,  the financial  statement  schedule  listed in the
index appearing under Item 14(a)(2) on page 64 presents fairly,  in all material
respects,  the information  set forth therein when read in conjunction  with the
related  consolidated  financial  statements.  These  financial  statements  and
financial statement schedule are the responsibility of the Company's management;
our  responsibility  is to express an opinion on these financial  statements and
financial  statement  schedule  based on our audits.  We conducted our audits of
these statements in accordance with auditing standards generally accepted in the
United  States,  which  require  that we plan and  perform  the  audit to obtain
reasonable assurance about whether the financial statements are free of material
misstatement.  An audit includes examining, on a test basis, evidence supporting
the  amounts  and  disclosures  in  the  financial  statements,   assessing  the
accounting  principles  used and significant  estimates made by management,  and
evaluating the overall  financial  statement  presentation.  We believe that our
audits provide a reasonable basis for the opinion expressed above.



/s/ PricewaterhouseCoopers LLP
PricewaterhouseCoopers LLP
St. Louis, Missouri
February 4, 2000

<TABLE>
<CAPTION>

CONSOLIDATED BALANCE SHEET

                                                                                                December 31,
(in thousands, except share data)                                                         1999                1998
<S>                                                                                    <C>                <C>
- --------------------------------------------------------------------------------------------------------------------------
Assets
Current assets:
   Cash and cash equivalents                                                           $     132,630      $      122,589
   Receivables, less allowance for doubtful
      accounts of $17,281 and $17,806, respectively                                          783,086             433,006
   Inventories                                                                               113,248              55,634
   Deferred taxes                                                                             32,248              41,011
   Prepaid expenses                                                                            5,143               4,667
                                                                                   ------------------- -------------------
        Total current assets                                                               1,066,355             656,907
                                                                                   ------------------- -------------------
Investment in marketable securities                                                          150,365                   -
Property and equipment, less accumulated depreciation and amortization                        97,573              77,499
Goodwill, less accumulated amortization                                                      982,496             282,163
Other intangible assets, less accumulated amortization                                       183,420              65,765
Other assets                                                                                   7,102              13,127
                                                                                   =================== ===================
        Total assets                                                                   $   2,487,311      $    1,095,461
                                                                                   =================== ===================

Liabilities and Stockholders' Equity Current liabilities:
   Current maturities of long-term debt                                                $           -      $       54,000
   Claims and rebates payable                                                                850,630             338,251
   Accounts payable                                                                          112,731              60,247
   Accrued expenses                                                                          136,997              86,798
                                                                                   ------------------- -------------------
        Total current liabilities                                                          1,100,358             539,296
Long-term debt                                                                               635,873             306,000
Other liabilities                                                                             51,598                 471
                                                                                   ------------------- -------------------
        Total liabilities                                                                  1,787,829             845,767
                                                                                   ------------------- -------------------

Commitments and Contingencies (Notes 3, 7 and 9)

Stockholders' equity:
   Preferred stock, $0.01 par value, 5,000,000 shares authorized, and no shares
      issued and outstanding
   Class A Common Stock, $0.01 par value, 150,000,000 shares authorized,
      23,981,000 and 18,610,000 shares issued and outstanding, respectively                      240                 186
   Class B Common Stock, $0.01 par value, 31,000,000 shares authorized,
      15,020,000 shares issued and outstanding                                                   150                 150
   Additional paid-in capital                                                                418,921             110,099
   Accumulated other comprehensive income                                                     (9,521)                (74)
   Retained earnings                                                                         296,540             146,322
                                                                                   ------------------- -------------------
                                                                                             706,330             256,683
   Class A Common Stock in treasury at cost, 465,000 and 475,000 shares,
      respectively                                                                            (6,848)             (6,989)
                                                                                   ------------------- -------------------
        Total stockholders' equity                                                           699,482             249,694
                                                                                   ------------------- -------------------
        Total liabilities and stockholders' equity                                     $   2,487,311      $    1,095,461
                                                                                   =================== ===================
</TABLE>

See accompanying Notes to Consolidated Financial Statements.


<TABLE>
<CAPTION>

CONSOLIDATED STATEMENT OF OPERATIONS


                                                                                Year Ended December 31,
(in thousands, except per share data)                                 1999                1998                1997
<S>                                                               <C>                 <C>                 <C>
- -------------------------------------------------------------------------------------------------------------------------
Revenues:
   Revenues                                                       $    4,285,104      $    2,824,872      $    1,230,634
   Other revenues                                                          3,000                   -                   -
                                                               ------------------- ------------------- -------------------
                                                                       4,288,104           2,824,872           1,230,634
                                                               ------------------- ------------------- -------------------
Cost and expenses:
   Cost of revenues                                                    3,826,905           2,584,997           1,119,167
   Selling, general and administrative                                   294,194             148,990              62,617
   Non-recurring                                                          30,221               1,651                   -
                                                               ------------------- ------------------- -------------------
                                                                       4,151,320           2,735,638           1,181,784
                                                               ------------------- ------------------- -------------------
Operating income                                                         136,784              89,234              48,850
                                                               ------------------- ------------------- -------------------
Other income (expense):
   Interest income                                                         5,762               7,236               6,081
   Interest expense                                                      (60,010)            (20,230)               (225)
   Gain on sale of assets                                                182,930                   -                   -
                                                               ------------------- ------------------- -------------------
                                                                         128,682             (12,994)              5,856
                                                               ------------------- ------------------- -------------------
Income before income taxes                                               265,466              76,240              54,706
Provision for income taxes                                               108,098              33,566              21,277
                                                               ------------------- ------------------- -------------------
Income before extraordinary item                                         157,368              42,674              33,429
Extraordinary loss on early retirement of debt, net of taxes
   of $4,492                                                               7,150                   -                   -
                                                               =================== =================== ===================
Net income                                                        $      150,218      $       42,674      $       33,429
                                                               =================== =================== ===================

Basic earnings per share:
   Before extraordinary item                                      $         4.36      $         1.29      $        1.02
   Extraordinary loss on early retirement of debt                           0.20                   -                   -
                                                               ------------------- ------------------- -------------------
   Net income                                                     $         4.16      $         1.29      $        1.02
                                                               =================== =================== ===================
Weighted average number of common shares
   outstanding during the period - Basic EPS                              36,095              33,105              32,713
                                                               =================== =================== ===================

Diluted earnings per share
   Before extraordinary item                                      $         4.25      $         1.27      $        1.01
   Extraordinary loss on early retirement of debt                           0.19                   -                   -
                                                               ------------------- ------------------- -------------------
   Net income                                                     $         4.06      $         1.27      $        1.01
                                                               =================== =================== ===================
Weighted average number of common shares
   outstanding during the period - Diluted EPS                            37,033              33,698              33,122
                                                               =================== =================== ===================
</TABLE>

See accompanying Notes to Consolidated Financial Statements



CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS' EQUITY

<TABLE>
<CAPTION>
                            Number of Shares                                         Amount
                           -------------------------------------------------------------------------------------------------
                                                                                   Accumulated
                           Class A    Class B       Class A   Class B   Additional Other
                            Common    Common       Common     Common     Paid-in  Comprehensive Retained   Treasury
(in thousands)              Stock      Stock         Stock     Stock     Capital     Income     Earnings    Stock      Total
<S>                         <C>       <C>         <C>        <C>       <C>        <C>         <C>        <C>       <C>
- -----------------------------------------------    --------------------------------------------------------------------------
Balance at December 31,
1996                          8,974     7,510       $    90    $    75   $98,958    $      (2)  $70,219    $(5,250)  $164,090
                           --------- ----------    ---------- --------- ---------- ----------- ---------- --------- ----------
  Comprehensive income:
    Net income                    -         -             -          -         -            -    33,429          -    33,429
    Other comprehensive
     income, Foreign currency
     translation adjustment       -         -             -          -         -          (25)        -          -       (25)
                           --------- ----------    ---------- --------- ---------- ----------- ---------- --------- ----------
  Comprehensive income            -         -             -          -         -          (25)   33,429          -    33,404
  Exercise of stock options     264         -             3          -     4,769            -         -          -     4,772
  Tax benefit relating to
    employee stock options        -         -             -          -     3,174            -         -          -     3,174
  Treasury Stock acquired         -         -             -          -         -            -         -     (1,739)   (1,739)
                           --------- ----------    ---------- --------- ---------- ----------- ---------- --------- ----------
Balance at December 31,1997   9,238     7,510            93         75   106,901          (27)  103,648     (6,989)  203,701
                           --------- ----------    ---------- --------- ---------- ----------- ---------- --------- ----------
  Comprehensive income:
    Net income                    -         -             -          -         -            -    42,674          -    42,674
    Other comprehensive
     income,Foreign currency
     translation adjustment       -         -             -          -         -          (47)        -          -       (47)
                           --------- ----------    ---------- --------- ---------- ----------- ---------- --------- ----------
  Comprehensive income            -         -             -          -         -          (47)   42,674          -    42,627
  Issuance of stock           9,239     7,510            92         75      (167)           -         -          -         -
    dividend
  Exercise of stock options     133         -             1          -     2,020            -         -          -     2,021
 Tax benefit relating to
    employee stock options        -         -             -          -     1,345            -         -          -     1,345
                           --------- ----------    ---------- --------- ---------- ----------- ---------- --------- ----------
Balance at December 31,      18,610    15,020           186        150   110,099          (74)  146,322     (6,989)  249,694
1998                       --------- ----------    ---------- --------- ---------- ----------- ---------- --------- ----------
  Comprehensive income:
    Net income                    -         -             -          -         -            -   150,218          -   150,219
    Other comprehensive
     income,Foreign currency
     translation adjustment       -         -             -          -         -          108         -          -       108
     Unrealized loss on
       investment, net
       of taxes of $6,000         -         -             -          -         -       (9,555)        -          -    (9,555)
                           --------- ----------    ---------- --------- ---------- ----------- ---------- --------- ----------
  Comprehensive income            -         -             -          -         -       (9,447)  150,218          -   140,771
  Issuance of common stock    5,175         -            52          -   299,326            -         -          -   299,378
  Exercise of stock options     186         -             2          -     5,744            -         -        141     5,887
  Common stock issued under
    employee plans               10         -             -                  551            -         -          -       551
  Tax benefit relating to
    employee stock options        -         -             -          -     3,201            -         -          -     3,201
                           ========= ==========    ========== ========= ========== =========== ========== ========= ==========
Balance at December 31,     23,981    15,020       $   240    $   150   $418,921   $  (9,521)  $296,540   $(6,848)  $699,482
1999                       ========= ==========    ========== ========= ========== =========== ========== ========= ==========

</TABLE>

See accompanying Notes to Consolidated Financial Statements

<TABLE>
<CAPTION>

CONSOLIDATED STATEMENT OF CASH FLOWS

                                                                                Year Ended December 31,
(in thousands)                                                        1999                1998                1997
<S>                                                                  <C>                 <C>                 <C>
- ------------------------------------------------------------------------------------------------------------------------------
Cash flows from operating activities:
   Net income                                                        $   150,218         $    42,674         $    33,429
   Adjustments to reconcile net income to net cash
     provided by operating activities:
       Depreciation and amortization                                      74,031              27,058              10,358
       Deferred income taxes                                              76,217              10,068                (834)
       Bad debt expense                                                    4,989               4,583               3,680
       Gain on sale of assets, net of cash paid                         (185,650)                  -                   -
       Non-recurring charges, net of cash paid                            22,281               1,467                   -
       Tax benefit relating to employee stock options                      3,201               1,345               3,174
       Extraordinary loss on early retirement of debt                     11,642                   -                   -
       Changes in operating  assets and  liabilities,
         net of changes  resulting from acquisition:
           Receivables                                                  (217,977)            (35,083)            (50,166)
           Inventories                                                   (54,059)            (15,417)            (11,444)
           Prepaid expenses and other assets                              (2,177)                756               1,722
           Claims and rebates payable                                    279,714             107,660              57,968
           Accounts payable and accrued expenses                          51,629             (18,537)              4,504
                                                               ------------------- ------------------- -------------------
Net cash provided by operating activities                                214,059             126,574              52,391
                                                               ------------------- ------------------- -------------------

Cash flows from investing activities:
   Acquisitions, net of cash acquired                                   (722,618)           (460,137)                  -
   Short-term investments                                                      -              57,938              (3,550)
   Purchases of property and equipment                                   (36,958)            (23,853)            (12,905)
                                                               ------------------- ------------------- -------------------
Net cash (used in) investing activities                                 (759,576)           (426,052)            (16,455)
                                                               ------------------- ------------------- -------------------

Cash flows from financing activities:
   Proceeds from long-term debt                                        1,290,950             360,000                   -
   Repayment of long-term debt                                        (1,015,000)                  -                   -
   Net proceeds from issuance of common stock                            299,378                   -                   -
   Deferred financing fees                                               (26,316)             (4,062)                  -
   Acquisition of treasury stock                                               -                   -              (1,739)
   Exercise of stock options                                               6,438               2,021               4,772
                                                               ------------------- ------------------- -------------------
Net cash provided by financing activities                                555,450             357,959               3,033
                                                               ------------------- ------------------- -------------------

Effect of foreign currency translation adjustment                            108                 (47)                (25)
                                                               ------------------- ------------------- -------------------

Net increase in cash and cash equivalents                                 10,041              58,434              38,944
Cash and cash equivalents at beginning of year                           122,589              64,155              25,211
                                                               =================== =================== ===================
Cash and cash equivalents at end of year                             $   132,630         $   122,589         $    64,155
                                                               =================== =================== ===================

Supplemental data:
Cash paid during the year for:
   Restructuring charges                                             $     4,683         $       184         $         -
   Income taxes                                                      $     1,080         $    17,202         $    20,691
   Interest                                                          $    61,607         $    13,568         $       225

</TABLE>

See accompanying Notes to Consolidated Financial Statements


NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

1.       Summary of significant accounting policies

     Organization  and  operations.  We are a  leading  specialty  managed  care
company and the largest full-service pharmacy benefit management ("PBM") company
independent of pharmaceutical manufacturer ownership and drug store ownership in
North America. We provide health care management and administration  services on
behalf of thousands of clients that include  health  maintenance  organizations,
health  insurers,  third-party  administrators,  employers  and  union-sponsored
benefit  plans.  Our  fully  integrated  PBM  services  include  network  claims
processing,   mail  pharmacy  services,   benefit  design   consultation,   drug
utilization review, formulary management,  disease management,  medical and drug
data analysis services,  medical information  management services (which include
the development of data  warehouses to combine  medical claims and  prescription
drug  claims),  disease  management  support  services  and outcome  assessments
through our Health  Management  Services division and Practice Patterns Science,
Inc. ("PPS")  subsidiary,  and informed decision counseling services through our
Express Health LineSM  division.  We also provide non-PBM services which include
infusion  therapy  services  through our  wholly-owned  subsidiary  IVTx,  Inc.,
operating as Express Scripts Infusion  Services,  distribution  services through
our Express Scripts Specialty  Distribution  Services subsidiary,  and, prior to
September  1,  1998,   provided   managed  vision  care  programs   through  our
wholly-owned subsidiary Express Scripts Vision Corporation.

     Basis of presentation.  The consolidated  financial  statements include our
accounts and all our  wholly-owned  subsidiaries.  All significant  intercompany
accounts  and  transactions  have  been  eliminated.   The  preparation  of  the
consolidated  financial  statements  conforms to generally  accepted  accounting
principles in the U.S., and requires us to make estimates and  assumptions  that
affect  the  reported  amounts  of  assets  and  liabilities  at the date of the
financial  statements and the reported  amounts of revenues and expenses  during
the  reporting  period.  Actual  amounts  could differ from those  estimates and
assumptions.

     Cash and cash equivalents.  Cash and cash equivalents  include cash on hand
and temporary  investments  in money market funds.  In 1999, we changed  certain
banking  relationships  resulting in certain cash  disbursement  accounts  being
maintained by banks not holding our cash  concentration  accounts.  As a result,
cash disbursement  accounts carrying negative balances have been reclassified to
claims and rebates payable at December 31, 1999.

     Inventories. Inventories consist of prescription drugs and medical supplies
that are stated at the lower of first-in first-out cost or market.

     Property and  equipment.  Property and  equipment is carried at cost and is
depreciated using the straight-line  method over estimated useful lives of seven
years for furniture,  five years for equipment and purchased  computer  software
and three years for personal computers.  Leasehold improvements are amortized on
a  straight-line  basis  over the term of the  lease or the  useful  life of the
asset,  if shorter.  Expenditures  for  repairs,  maintenance  and  renewals are
charged to income as incurred. Expenditures which improve an asset or extend its
estimated useful life are capitalized.  When properties are retired or otherwise
disposed of, the related cost and accumulated  depreciation are removed from the
accounts and any gain or loss is included in income.

     Software  development costs.  During 1997, we adopted Statement of Position
98-1 ("SOP 98-1"),  Accounting for the Costs of Computer  Software  Developed or
Obtained for Internal Use. SOP 98-1 requires the capitalization of certain costs
associated with computer software  developed or obtained for internal use. Given
the limited  software  developed or obtained for internal use in 1997,  adoption
had  virtually  no effect on our  Consolidated  Statement of  Operations  or our
financial position.  However, the impact of SOP 98-1 on an ongoing basis will be
determined  by the  magnitude  of computer  software  developed  or obtained for
internal use. Research and development  expenditures relating to the development
of software to be marketed to clients, or to be used for internal purposes,  are
charged to expense until technological  feasibility is established.  Thereafter,
the remaining  software  production  costs up to the date of general  release to
customers,  or to the date placed into production,  are capitalized and included
as Property and Equipment. During 1999, 1998 and 1997, $15,997,000,  $10,244,000
and $1,982,000 in software  development  costs were  capitalized,  respectively,
primarily due to the  integration of our  acquisitions  and  enhancements to our
information   systems.   Capitalized  software  development  costs  amounted  to
$42,353,000  and  $27,516,000  at  December  31,  1999 and  1998,  respectively.
Amortization of the capitalized amounts commences on the date of general release
to  customers,  or  the  date  placed  into  production,  and is  computed  on a
product-by-product  basis  using the  straight-line  method  over the  remaining
estimated economic life of the product but not more than five years. Reductions,
if any, in the carrying  value of  capitalized  software costs to net realizable
value are included in non-recurring expense.  Amortization expense in 1999, 1998
and 1997 was $3,810,000, $1,968,000 and $622,000, respectively.

     Marketable securities.  All investments not included in a money market fund
are accounted for under Financial  Accounting Standards Board ("FASB") Statement
No. 115,  "Accounting  for Certain  Investments in Debt and Equity  Securities."
Available-for-sale  securities  are reported at fair value,  which is based upon
quoted market prices,  with unrealized gains and losses, net of tax, reported as
a  component  of  other  comprehensive  income  in  stockholders'  equity  until
realized.  Unrealized  losses are charged  against income when a decline in fair
value is determined to be other than temporary.

     At December 31, 1999,  available-for-sale  securities totaled $150,365,000,
with  related  gross  unrealized  losses,  net of  taxes  of  $9,555,000.  These
investments  consist of shares of PlanetRx.com,  Inc.  ("PlanetRx") common stock
(see Note 2). There were no marketable securities in 1998.

     Goodwill.  Goodwill is amortized on a straight-line basis over periods from
10 to 30 years.  The  amount  reported  is net of  accumulated  amortization  of
$36,317,000  and  $8,114,000  at December  31, 1999 and 1998,  respectively.  We
periodically  evaluate  the  carrying  value of  goodwill  for  impairment.  The
evaluation of impairment is based on expected future  operating cash flows on an
undiscounted  basis for the  operations to which  goodwill  relates.  Impairment
losses, if any, would be determined based on the present value of the cash flows
using discount rates that reflect the inherent risk of the underlying  business.
In our  opinion,  no such  impairment  existed at  December  31,  1999 and 1998.
Amortization expense,  included in selling, general and administrative expenses,
was  $28,203,000,  $7,863,000 and $42,000 for the years ended December 31, 1999,
1998 and 1997, respectively.

     Other  intangible  assets.  Other  intangible  assets  consist of  customer
contracts,  non-compete agreements and deferred financing fees and are amortized
on a straight-line basis over periods from 2 to 20 years.  Amortization  expense
for customer contracts and non-compete  agreements included in selling,  general
and administrative  expenses was $25,094,000,  $4,320,000 and $2,940,000 for the
years ended December 31, 1999, 1998 and 1997, respectively. Amortization expense
for deferred  financing fees included in interest  expense was  $2,241,000,  and
$609,000  for the years ended  December 31, 1999 and 1998,  respectively.  There
were no deferred financing charges in 1997.

     Contractual  agreements.  We have entered  into  corporate  alliances  with
certain of our clients  whereby  shares of our Class A Common Stock were awarded
as advance discounts to the clients. We account for these agreements as follows:

     Prior to December 15, 1995 - For agreements  consummated  prior to December
15, 1995, the stock is valued  utilizing the quoted market value at the date the
agreement is consummated  if the number of shares to be issued is known.  If the
number  of  shares to be issued  is  contingent  upon the  occurrence  of future
events,  the stock is valued  utilizing  the quoted market value at the date the
contingency is satisfied and the number of shares is determinable.

     Between  December 15, 1995 and November 20, 1997 - For  agreements  entered
into between  these dates,  we utilize the  provisions  of Financial  Accounting
Standards   Board   Statement   ("FAS")   123,   "Accounting   for   Stock-Based
Compensation," which requires that all stock issued to nonemployees be accounted
for based on the fair value of the  consideration  received or the fair value of
the equity instruments issued instead of the intrinsic value method utilized for
stock issued or to be issued under alliances  entered into prior to December 15,
1995.  We have  adopted  FAS 123 as it relates  to stock  issued or to be issued
under the Premier  and  Manulife  alliances  based on fair value at the date the
agreement was consummated.

     Subsequent  to November 20, 1997 - In November  1997,  the Emerging  Issues
Task Force of the FASB reached a consensus that the value of equity  instruments
issued  for  consideration  other than  employee  services  should be  initially
determined on the date on which a "firm commitment" for performance first exists
by the provider of goods or services. Firm commitment is defined as a commitment
pursuant  to which  performance  by a provider  of goods or services is probable
because of sufficiently large  disincentives for  nonperformance.  The consensus
must  be  applied  for  all  new  arrangements  and  modifications  of  existing
arrangements  entered into from November 20, 1997.  The consensus only addresses
the date upon which fair value is determined  and does not change the accounting
based upon fair value as  prescribed  by FAS 123. We have not  entered  into any
such arrangements subsequent to November 20, 1997.

     Shares  issued  on the  effective  date of the  contractual  agreement  are
considered  outstanding  and  included in basic and diluted  earnings  per share
computations  when issued.  Shares  issuable  upon the  satisfaction  of certain
conditions  are  considered  outstanding  and  included  in basic  and  dilutive
earnings per share computation when all necessary conditions have been satisfied
by the end of the period. If all necessary conditions have not been satisfied by
the end of the period,  the number of shares  included in the dilutive  earnings
per share  computation  is based on the number of shares,  if any, that would be
issuable  if the end of the  reporting  period  were the end of the  contingency
period and if the  result  would be  dilutive.  The value of the shares of stock
awarded as advance  discounts  is  recorded as a deferred  cost and  included in
other intangible assets. The deferred cost is recognized in selling, general and
administrative expenses over the period of the contract.

     Impairment  of  long  lived  assets.   We  evaluate   whether   events  and
circumstances have occurred that indicate the remaining estimated useful life of
long lived assets may warrant revision or that the remaining balance of an asset
may not be recoverable.  The measurement of possible  impairment is based on the
ability to recover the balance of assets from  expected  future  operating  cash
flows on an undiscounted  basis.  Impairment losses, if any, would be determined
based on the present value of the cash flows using  discount  rates that reflect
the inherent risk of the  underlying  business.  In our opinion,  other than the
write-down of long-lived  assets  associated with our facilities  consolidation,
computer operations outsourcing and Express Scripts Vision Corporation,  no such
impairment existed as of December 31, 1999 or 1998 (see Note 7).

     Derivative financial  instruments.  We have entered into interest rate swap
agreements in order to manage  exposure to interest rate risk. We do not hold or
issue derivative financial  instruments for trading purposes.  The interest rate
swaps are designated as a hedge of our variable interest rate payments.  Amounts
received or paid are accrued as interest  receivable  or payable and as interest
income or expense. The fair values of interest rate swap agreements are based on
market  prices.  The  fair  values  represent  the  estimated  amount  we  would
receive/pay  to  terminate  the  agreements  taking into  consideration  current
interest rates.

     In  June  1998,  the  FASB  issued  FAS  133,  "Accounting  for  Derivative
Instruments  and Hedging  Activities".  FAS 133 requires all  derivatives  to be
recognized  as either  assets  or  liabilities  in the  statement  of  financial
position and to measure those  instruments at fair value.  In addition,  FAS 133
specifies the accounting for changes in the fair value of a derivative  based on
the intended use of the derivative and the resulting designation.  The effective
date for FAS 133 was  originally  effective  for all fiscal  quarters  of fiscal
years beginning after June 1, 1999. However, the FASB has deferred the effective
date so that it will begin for all fiscal  quarters  of fiscal  years  beginning
after June 15, 2000,  and will be applicable to our first quarter of fiscal year
2001. Our present  interest rate swaps (see Note 6) will be considered cash flow
hedges. Accordingly, the change in the fair values of the swaps will be reported
on the balance  sheet as an asset or  liability.  The  corresponding  unrealized
gains or losses  representing  the  effective  portions  of the  hedges  will be
initially recognized in stockholders' equity and other comprehensive income, and
subsequently  any  changes  in  unrealized  gains or  losses  from  the  initial
measurement  dates will be recognized in earnings  concurrent  with the interest
expense on our  underlying  variable  rate debt. If we had adopted FAS 133 as of
December 31, 1999, we would have recorded an unrealized gain of $6,867,000 as an
asset and an increase in  stockholder's  equity and other  comprehensive  income
during 1999.

     Fair value of financial  instruments.  The carrying  value of cash and cash
equivalents,  accounts receivable and accounts payable  approximated fair values
due to the short-term  maturities of these  instruments.  The fair value,  which
approximates  the carrying  value,  of our Credit  Facility was estimated  using
either  quoted  market  prices or the current  rates offered to us for debt with
similar maturity.  The fair value of the swaps ($6,867,000 asset at December 31,
1999 for both swaps and  $7,209,000  liability at December 31, 1998 for our only
swap) was based on quoted market prices, which reflect the present values of the
difference between estimated future fixed rate payments and future variable rate
receipts.  The fair value of our senior note facility  ($255,000,000 at December
31, 1999) was estimated based on quoted market prices.

     Revenue   recognition.    Revenues   from   dispensing   prescription   and
non-prescription  medical  products from our mail  pharmacies  are recorded upon
shipment.  Revenue  from  sales  of  prescription  drugs  by  pharmacies  in our
nationwide  network and pharmacy claims processing  revenues are recognized when
the claims are processed.  When we dispense pharmaceuticals to members of health
benefit  plans  sponsored  by our  clients  or have an  independent  contractual
obligation  to pay our  network  pharmacy  providers  for  benefits  provided to
members of our clients'  pharmacy  benefit plans, we include  payments from plan
sponsors for these benefits as revenue and ingredient costs or payments to these
pharmacy  providers  in cost of  revenues  (the "Gross  Basis").  If we are only
administering  the  plan  sponsors'  network  pharmacy  contracts,  or  where we
dispense  pharmaceuticals  supplied  by one of our  clients,  we record only the
administrative  or  dispensing  fees  derived from our  contracts  with the plan
sponsors as revenue (the "Net Basis").

     Management services provided to drug manufacturers include various services
relating to administration of a manufacturer  rebate program.  Revenues relating
to these services are recognized as earned based upon detailed drug  utilization
data.  Rebates payable to customers in accordance with the applicable  contracts
are excluded from revenues and expenses.

     Retail pharmacy and mail pharmacy revenues are recognized based upon actual
scripts adjudicated and therefore require no estimation. Amounts remain unbilled
for no more than 30 days based upon the contractual billing schedule agreed with
the  client.  At December  31,  1999 and 1998,  all  unbilled  receivables  were
$416,740,000 and $209,334,000, respectively.

     Cost of revenues.  Cost of revenues includes product costs, pharmacy claims
payments and other direct costs  associated  with dispensing  prescriptions  and
non-prescription  medical products and claims processing  operations,  offset by
fees  received from  pharmaceutical  manufacturers  in connection  with our drug
purchasing and formulary management  programs.  We estimate fees receivable from
pharmaceutical manufacturers on a quarterly basis converting total prescriptions
dispensed to estimated rebatable scripts (i.e., those prescriptions with respect
to which we are contractually  entitled to submit claims for rebates) multiplied
by  the  contractually   agreed  manufacturer  rebate  amount.   Estimated  fees
receivable from pharmaceutical manufacturers are recorded when we determine them
to be realizable,  and  realization is not dependent upon future  pharmaceutical
sales.  Estimates are revised once the actual  rebatable  scripts are calculated
and rebates are billed to the manufacturer.

     Income taxes.  Deferred tax assets and liabilities are recognized  based on
temporary  differences between financial statement basis and tax basis of assets
and liabilities using presently enacted tax rates.

     Earnings per share. Basic earnings per share is computed using the weighted
average number of common shares outstanding during the period.  Diluted earnings
per share is computed in the same  manner as basic  earnings  per share but adds
the number of additional  common shares that would have been outstanding for the
period  if the  potential  dilutive  common  shares  had been  issued.  The only
difference  between the number of weighted  average shares used in the basic and
diluted  calculation  for all years is stock options and stock  warrants we have
granted using the "treasury  stock"  method,  amounting to 938,000,  593,000 and
409,000 in 1999, 1998 and 1997, respectively.

     Foreign currency translation.  The financial statements of ESI Canada, Inc.
are translated  into U.S.  Dollars using the exchange rate at each balance sheet
date for assets and  liabilities and a weighted  average  exchange rate for each
period for revenues, expenses, gains and losses. The functional currency for ESI
Canada,  Inc. is the local  currency and  translation  adjustments  are recorded
within the other comprehensive income component of stockholders' equity.

     Employee stock-based compensation. We account for employee stock options in
accordance with Accounting  Principles Board No. 25 ("APB 25"),  "Accounting for
Stock Issued to Employees." Under APB 25, we apply the intrinsic value method of
accounting and,  therefore,  do not recognize  compensation  expense for options
granted,  because  options are only  granted at a price equal to market value at
the time of  grant.  During  1996,  FAS 123  became  effective  for us.  FAS 123
prescribes the  recognition of  compensation  expense based on the fair value of
options determined on the grant date. However,  FAS 123 grants an exception that
allows  companies  currently  applying APB 25 to continue using that method.  We
have,  therefore,  elected to continue applying the intrinsic value method under
APB 25. For  companies  that choose to continue  applying  the  intrinsic  value
method,  FAS 123  mandates  certain pro forma  disclosures  as if the fair value
method had been utilized (see Note 12).

     Comprehensive  income.  During  1998,  FAS  130,  "Reporting  Comprehensive
Income,"  became   effective  for  us.  FAS  130  requires  noncash  changes  in
stockholders' equity be combined with net income and reported in a new financial
statement category entitled  "comprehensive  income." Other than net income, our
two  components  of  comprehensive  income are changes in the  foreign  currency
translation adjustments and unrealized losses on available-for-sale  securities.
We have  displayed  comprehensive  income  within  the  Statement  of Changes in
Stockholders' Equity.

     Segment reporting.  During 1998, FAS 131, "Disclosures about Segments of an
Enterprise and Related  Information,"  became effective for us. FAS 131 requires
that we report certain information,  if specific requirements are met, about our
operating  segments  including  information about services,  geographic areas of
operation  and  major  customers.  The  information  is to be  derived  from the
management  approach which designates the internal  organization that is used by
management  for making  operating  decisions  and assessing  performance  as the
source  of our  reportable  segments.  Adoption  of FAS 131 did not  affect  our
results of operations or our financial position but did affect the disclosure of
segment information (see Note 13).

2.       Changes in business

     Acquisition.  On April 1, 1999, we completed our acquisition of Diversified
Pharmaceutical  Services,  Inc. and Diversified  Pharmaceutical Services (Puerto
Rico) Inc.  (collectively,  "DPS"),  from  SmithKline  Beecham  Corporation  and
SmithKline  Beecham  InterCredit BV (collectively,  "SB") for approximately $715
million,  which includes a purchase price adjustment for closing working capital
and transaction costs. We filed an Internal Revenue Code ss.338(h)(10) election,
making  amortization  expense of  intangible  assets,  including  goodwill,  tax
deductible.  We used  approximately $48 million of our own cash and financed the
remainder of the purchase  price and related  acquisition  costs through a $1.05
billion  credit  facility and a $150 million senior  subordinated  bridge credit
facility (see Note 6).

     The  acquisition  has been  accounted  for  using  the  purchase  method of
accounting.  The  results  of  operations  of  DPS  have  been  included  in the
consolidated  financial  statements  and  pharmacy  benefit  management  ("PBM")
segment since April 1, 1999. The purchase price has been preliminarily allocated
based on the  estimated  fair  values of net assets  acquired at the date of the
acquisition.  The excess of purchase price over tangible net assets acquired has
been  preliminarily  allocated to other intangible assets consisting of customer
contracts  in the amount of  $129,500,000  which are being  amortized  using the
straight-line  method  over the  estimated  useful  lives  of 1 to 20 years  and
goodwill  in the  amount  of  $734,485,000  which is being  amortized  using the
straight-line  method over the estimated useful life of 30 years. In conjunction
with the acquisition, DPS retained the following liabilities:

<TABLE>
<CAPTION>

(in thousands)
<S>                                          <C>
- --------------------------------------- -----------------------
Fair value of assets acquired                $     1,010,159
Cash paid for the capital stock                     (714,678)
                                        =======================
         Liabilities retained                $       295,481
                                        =======================
</TABLE>

     On April 1, 1998 we acquired all of the outstanding  capital stock of Value
Health,  Inc. and Managed  Prescriptions  Network,  Inc.  (collectively known as
"ValueRx")   from   Columbia/HCA   Healthcare   Corporation   ("Columbia")   for
approximately  $460  million  in cash  (which  includes  transaction  costs  and
executive  management  severance  costs of  approximately  $6.7 million and $8.3
million, respectively), approximately $360 million of which was obtained through
a five-year  bank credit  facility (see Note 6) and the remainder  from our cash
balances and short term investments.

     The  acquisition  has been  accounted  for  using  the  purchase  method of
accounting  and the results of  operations  of ValueRx have been included in the
consolidated  financial  statements  and PBM segment  since  April 1, 1998.  The
purchase  price has been  allocated  based on the  estimated  fair values of net
assets  acquired at the date of the  acquisition.  The excess of purchase  price
over tangible net assets acquired has been allocated to other intangible  assets
consisting  of customer  contracts and  non-compete  agreements in the amount of
$57,653,000  which are being amortized using the  straight-line  method over the
estimated  useful  lives  of 2 to  20  years  and  goodwill  in  the  amount  of
$278,113,000  which is being amortized using the  straight-line  method over the
estimated  useful  life of 30  years.  The  amortization  expense  from  ValueRx
goodwill and customer  contracts is non-deductible  for income tax purposes.  In
conjunction  with the  acquisition,  ValueRx and its  subsidiaries  retained the
following liabilities:

<TABLE>
<CAPTION>

 (in thousands)
<S>                                               <C>
- --------------------------------------------- -----------------------
Fair value of assets acquired                     $        659,166
Cash paid for the capital stock                           (460,137)
                                              =======================
       Liabilities retained                       $        199,029
                                              =======================
</TABLE>

     The  following  unaudited pro forma  information  presents a summary of our
combined  results  of  operations  and  those  of  DPS  and  ValueRx  as if  the
acquisitions had occurred at the beginning of the periods presented,  along with
certain pro forma adjustments to give effect to amortization of goodwill,  other
intangible  assets,  interest expense on acquisition debt and other adjustments.
The pro forma financial information is not necessarily indicative of the results
of operations as they would have been had the transactions  been effected on the
assumed dates, nor are they an indication of trends in future results.  Included
in the pro forma information are integration costs incurred by us that are being
reported within selling, general and administrative expenses in the statement of
operations.  Additionally,  the year ended December 31, 1998 includes the impact
of a write-down of assets of $1,092,184,000,  $709,920,000 after tax, related to
the  impairment of DPS's  goodwill.  If the  acquisition  of DPS had occurred on
January 1, 1998, goodwill on DPS's books would have been eliminated.  Therefore,
the  impairment  charge for  goodwill  would not have  existed.  Excluding  this
write-down,  our pro forma net  income  for  fiscal  year 1998  would  have been
$30,461,000, or $0.92 per basic share and $0.90 per diluted share.

<TABLE>
<CAPTION>

                                                  Year Ended December 31,
(in thousands, except per share data)         1999             1998
<S>                                          <C>             <C>
- ----------------------------------------------------------------------------
Total revenues                               $  4,353,470    $  3,449,649
Income (loss) before extraordinary loss           158,526        (679,459)
Extraordinary loss                                  7,150               -
Net income (loss)                                 151,376        (679,459)
Basic earnings per share
    Before extraordinary loss                        4.39          (20.52)
    Extraordinary loss                               0.20               -
                                             -------------------------------
    Net income (loss)                                4.19          (20.52)
Diluted earnings per share
    Before extraordinary loss                        4.28          (20.16)
    Extraordinary loss                               0.19               -
                                             -------------------------------
    Net income (loss)                                4.09          (20.16)
</TABLE>

     Sale of assets. On August 31, 1999, we, along with  YourPharmacy.com,  Inc.
("YPC"),  our wholly-owned  subsidiary,  entered into an Asset  Contribution and
Reorganization  Agreement (the  "Contribution  Agreement")  with  PlanetRx,  PRX
Holdings,  Inc.  ("Holdings"),  and PRX Acquisition Corp.  ("Acquisition  Sub").
Pursuant  to the  Contribution  Agreement,  YPC  agreed  to  contribute  certain
operating  assets  constituting  its  e-commerce  business in  prescription  and
non-prescription  drugs and health and beauty aids to  Holdings in exchange  for
19.9% of the post-initial public offering common equity of Holdings (the "IPO"),
and PlanetRx was also to assume certain obligations of YPC.  Simultaneously with
this  transaction,  Acquisition  Sub was to merge  into  PlanetRx  and  PlanetRx
shareholders  would  receive  stock in Holdings,  which would change its name to
"PlanetRx.com  Inc."  As a  result  of the  transactions,  YPC  would be a 19.9%
shareholder  in the  new  PlanetRx  (formerly  Holdings),  which  would  conduct
business as an Internet pharmacy.

     On  October  13,  1999,  the  transactions  described  in the  Contribution
Agreement were  consummated,  YPC received  10,369,990  unregistered  shares, or
19.9%, of the common equity of PlanetRx, and PlanetRx assumed options granted to
YPC employees which converted into options to purchase approximately 1.8 million
shares of PlanetRx  common stock. In connection with the IPO, we also executed a
180 day lock-up  agreement  that prevents us from selling our shares until April
10, 2000. The consummation of the transaction occurred immediately preceding the
closing of  PlanetRx's  IPO of common  stock.  Based on the IPO price of $16 per
share, YPC received consideration valued at $165,920,000. We recorded a one-time
gain (in other income) of $182,930,000 on the transaction,  and a one-time stock
compensation  expense  (included  in  non-recurring   expenses)  of  $19,520,000
relating  to the  YPC  employee  stock  options.  We  are  accounting  for  this
investment in PlanetRx on the cost method and therefore reporting our investment
on the balance sheet under the caption "investment in marketable  securities" at
fair value in accordance with FAS 115 (see Note 1).

     As part of our agreement, PlanetRx will pay us an annual fee of $11,650,000
and  reimbursement  for certain expenses of $3,000,000 over a 5 year term, which
can  be  extended  to  10  years  if  we  meet  certain  performance   measures.
Additionally,  we are  eligible  to  receive an  incremental  fee based upon the
number of our members who placed  their  first  order for  prescription  drug or
non-prescription merchandise with PlanetRx. We recorded $2,912,000 of the annual
fee and $88,000 of incremental  fee in other revenue and we have reduced selling
and general  administrative  expenses by $750,000 for  reimbursement  of certain
expenses relating to our Internet  initiative.  As of December 31, 1999, we have
PlanetRx receivables of $5,732,000.

3.       Contractual agreements

     On December 31, 1995,  we entered into a ten-year  corporate  alliance with
Premier  Purchasing  Partners,  L.P.  (formerly,   American  Healthcare  Systems
Purchasing  Partners,  L.P., the "Partnership"),  an affiliate of Premier,  Inc.
("Premier").  Premier is an alliance of health care systems  resulting  from the
merger in 1995 of American  Healthcare  Systems,  Premier  Health  Alliance  and
SunHealth  Alliance.  Under  the  terms  of the  transaction,  we are  Premier's
preferred   vendor  of  pharmacy  benefit   management   services  to  Premier's
shareholder  systems and their managed care  affiliates and will issue shares of
our Class A Common Stock as an  administrative  fee to the Partnership  based on
the  attainment  of  certain  benchmarks,  principally  related to the number of
members   receiving  our  pharmacy   benefit   management   services  under  the
arrangement,  and to the  achievement  of certain  joint  purchasing  goals.  In
accordance with the terms of the agreement,  we issued 454,546 shares of Class A
Stock to Premier in May 1996.  The shares were valued at  $11,250,000  using our
closing  stock  price  on  December  31,  1995,   the  date  the  agreement  was
consummated,  and are  being  amortized  over  the  then  remaining  term of the
agreement.   Amortization  expense  in  1999,  1998  and  1997  was  $1,320,000,
$1,164,000 and  $1,164,000,  respectively.  We may be required to issue up to an
additional  4,500,000  shares to the  Partnership  over a period up to the first
five  years of the  agreement  if the  Partnership  exceeds  all  benchmarks.  A
calculation  is made on April 1 of each year to  determine  if a stock  issuance
will be made.  Premier has asserted  that is has earned  additional  shares.  We
disagree with this contention, and we are in discussions with Premier concerning
this  matter.  To date,  we have not issued any  additional  shares.  Except for
certain exemptions from registration under the Securities Act of 1933 ("the 1933
Act"),  any shares  issued to the  Partnership  cannot be traded until they have
been registered under the 1933 Act and any applicable state securities laws.

     Effective  January 1, 1996,  we  executed a  multi-year  contract  with The
Manufacturers Life Insurance Company ("Manulife"), to introduce pharmacy benefit
management  services in Canada.  Manulife's Group Benefits Division continues to
work  with  ESI  Canada  to  provide  these  services.  Under  the  terms of the
agreement,  we are  the  exclusive  third-party  provider  of  pharmacy  benefit
management services to Manulife's Canadian clients. We will also issue shares of
our  Class A  Common  Stock  as an  advance  discount  to  Manulife  based  upon
achievement of certain volumes of Manulife pharmacy claims we process. No shares
will be issued  until  after the fourth year of the  agreement  based on volumes
reached in years two through four.  We  anticipate  issuing no more than 474,000
shares to  Manulife  over a period  up to the first six years of the  agreement.
Except for certain  exemptions from registration  under the 1933 Act, any shares
issued to Manulife  cannot be traded until they have been  registered  under the
1933 Act and any applicable  state securities laws. In accordance with the terms
of the agreement, no stock has been issued since inception.

     If Manulife has not exercised an early termination option at the end of the
sixth or tenth year of the  agreement,  we will  issue at each of those  times a
ten-year warrant as an advance discount to purchase up to approximately  237,000
additional  shares of our Class A Common Stock  exercisable at 85% of the market
price at those times.  The actual  number of shares for which such warrant is to
be issued is based on the volume of Manulife  pharmacy claims we process in year
six and year ten, respectively.

     Pursuant to an agreement with Coventry  Corporation,  an operator of health
maintenance  organizations  located principally in Pennsylvania and Missouri, on
January 3, 1995,  we issued  50,000 shares of Class A Common Stock as an advance
discount to Coventry in a private placement.  These shares were valued at $13.69
per share, the split-adjusted per share market value of our Class A Common Stock
on November 22, 1994,  which was the date the agreement was  consummated and the
obligation of the parties became unconditional. No revision of the consideration
for the transaction  occurred between November 22, 1994 and January 3, 1995. The
shares issued to Coventry were being amortized over a six-year period.  However,
due to Coventry  extending the agreement for only two years, as discussed below,
instead of three years,  the estimated useful life of the shares issued has been
reduced  to five years and ended in 1999.  Amortization  expense  was  $171,000,
$171,000 and $114,000  for each of the years ended  December 31, 1999,  1998 and
1997,  respectively.  Except for certain  exemptions from registration under the
1993 Act,  these shares cannot be traded until they have been  registered  under
the 1933 Act and any applicable state securities laws.

     Effective  January 1, 1998,  Coventry  renewed the agreement for a two-year
term through December 31, 1999. As part of the agreement,  we issued warrants as
an advance  discount  to  purchase an  additional  50,000  shares of our Class A
Common  Stock,  exercisable  at 90% of the market  value at the time of renewal.
During 1998,  we expensed the advance  discount,  which  represented  10% of the
market value.

     On October 13, 1992, we entered into a five-year arrangement with FHP, Inc.
("FHP")  pursuant to which we agreed to provide pharmacy benefit services to FHP
and  its  members.  FHP is an  operator  of  health  maintenance  organizations,
principally in the western United States.  In February 1997,  PacifiCare  Health
Systems,  Inc.  ("PacifiCare")  completed the acquisition of FHP. As a result of
the  merger,  PacifiCare  informed  us that it would not enter into a  long-term
extension  of the  agreement  and  reached  an  agreement  with us to  phase-out
membership starting in July 1997 and continued through March 1998.

     In accordance with the agreement,  we commenced  providing pharmacy benefit
services to FHP and its members on January 4, 1993. On the commencement date and
pursuant to the agreement,  we issued 400,000 shares of our Class A Common Stock
as advance discounts to FHP in a private placement.  These shares were valued at
$4.13 per share, the split-adjusted per share market value of our Class A shares
on October 13, 1992,  which was the date the agreement was  consummated  and the
obligations   of  the  parties   became   unconditional.   No  revision  of  the
consideration for the transaction  occurred between October 13, 1992 and January
4, 1993.  The cost of the shares  issued to FHP was  amortized  over a five-year
period  ending in 1997.  No  amortization  expense was recorded in 1999 or 1998.
Amortization expense was $990,000 in 1997.

4.       Related party transactions

     As discussed in Note 3, we have entered into a ten year corporate  alliance
with Premier.  Richard Norling is the Chief  Executive  Officer of Premier and a
member of our Board of Directors. No consideration,  monetary or otherwise,  has
been  exchanged  between  Premier and us between the period  September  1997 and
December  1999 (the period  during which Premier is a related party with us). We
may be  required  to issue  additional  shares  of our  Class A Common  Stock to
Premier as discussed in Note 3.

     Premier is required to promote us as the  preferred  PBM provider to health
care entities,  plans and facilities,  which participate in Premier's purchasing
programs.  However,  all contractual  arrangements to provide  services are made
directly  between these entities and us, at varying terms and independent of any
Premier  involvement.  Therefore,  the associated  revenues  earned and expenses
incurred by us are not deemed to be related party transactions. During 1999, the
revenues  that we derived  from  services  provided to the health care  entities
participating in Premier's purchasing programs was $107,538,000.

5.       Property and equipment

         Property and equipment, at cost, consists of the following:
<TABLE>
<CAPTION>
                                                       December 31
(in thousands)                                   1999               1998
<S>                                       <C>                <C>
- ---------------------------------------------------------- ------------------
Land                                      $       2,051      $      2,051
Building                                          3,076             3,076
Furniture                                        12,873             8,336
Equipment                                        64,204            52,758
Computer software                                55,054            37,412
Leasehold improvements                            9,922             8,275
                                       ------------------- ------------------
                                                147,180           111,908
Less accumulated depreciation and
amortization                                     49,607            34,409
                                       =================== ==================
                                          $      97,573      $     77,499
                                       =================== ==================
</TABLE>

6.       Financing

         Long-term debt consists of:
<TABLE>
<CAPTION>
                                                   December 31,     December 31,
(in thousands)                                         1999             1998
<S>                                               <C>             <C>
- --------------------------------------------------------------------------------
Revolving credit facility due March 31, 2005
   with an interest rate of 7.94% at
   December 31, 1999                                $100,000               -
Term credit facility due April 15, 2003                    -        $360,000
Term A loans due March 31, 2005 with an interest
   rate of 7.94% at December 31, 1999               $285,000               -
9.625% Senior  Notes due June 15, 2009
   with an effective interest  rate of 9.7%
   and interest rate lock, net of unamortized
   discount of $1,146                               $250,873               -
                                                  ------------- ----------------
Total debt                                          $635,873        $360,000
Less current maturities                                    -          54,000
                                                  ============= ================
Long-term debt                                      $635,873        $306,000
                                                  ============= ================
</TABLE>

     On April 1, 1999,  we executed a $1.05  billion  credit  facility  ("Credit
Facility")  with a bank  syndicate led by Credit Suisse First Boston and Bankers
Trust Company,  consisting of $750 million in term loans, including $285 million
of Term A loans and $465 million of Term B loans,  and a $300 million  revolving
credit facility.  The Credit Facility is secured by the capital stock of each of
our existing and subsequently  acquired  domestic  subsidiaries,  excluding PPS,
Great Plains Reinsurance  Company ("Great Plains"),  ValueRx of Michigan,  Inc.,
Diversified NY IPA, Inc., and Diversified Pharmaceutical Services (Puerto Rico),
Inc., and is also secured by 65% of the stock of our foreign  subsidiaries.  The
provisions of the Credit Facility require  quarterly  interest payments based on
several London  Interbank  Offered Rates  ("LIBOR") or base rate options plus an
interest rate spread.  The Credit  Facility  contains  covenants  that limit the
indebtedness  we may  incur,  dividends  paid and the  amount of annual  capital
expenditures.  The covenants also establish a minimum interest coverage ratio, a
maximum  leverage ratio, and a minimum fixed charge coverage ratio. In addition,
we are required to pay an annual fee of 0.5%, payable in quarterly installments,
on the unused portion of the revolving credit facility ($200 million at December
31,  1999).  At December  31, 1999,  we were in  compliance  with all  covenants
associated with the Credit Facility. In January 2000, we paid down the revolving
credit facility by $30,000,000.

     Also on April 1, 1999,  we  executed  a $150  million  senior  subordinated
bridge  credit  facility  with Credit  Suisse  First  Boston and  Bankers  Trust
Company.  The  proceeds  from this  facility and  approximately  $890 million in
proceeds from the Credit  Facility were used to consummate  the DPS  acquisition
(see Note 2) and repay $360  million  outstanding  under our  pre-existing  $440
million  credit  facility.  This  facility  was  retired in June 1999,  upon the
completion of our equity offering (see Note 11).

     On June 16,  1999,  we  completed  the  offering of $250  million in Senior
Notes,  which require interest to be paid  semi-annually on June 15 and December
15.  The  Senior  Notes  also  provide  us an  opportunity  to call  the debt at
specified  rates  beginning in June 2004. The net proceeds from the Senior Notes
offering,  along with a portion of the net proceeds from the equity offering and
$23,901,000 of our own cash were used to repay $414,770,000 of the Term B loans.
In July 1999, we paid off the remaining Term B principal balance of $50,230,000.
As a result of the  refinancing  of the $440  million  credit  facility  and the
repayment  of the  Term  B  loans,  we  recognized  a  $7,150,000,  net of  tax,
extraordinary  loss from the write-off of deferred  financing  fees.  The Senior
Notes are unconditionally and joint and severally guaranteed by our wholly-owned
domestic subsidiaries other than PPS, Great Plains,  ValueRx of Michigan,  Inc.,
Diversified  NY IPA, and  Diversified  Pharmaceutical  Services  (Puerto  Rico).
Separate  financial  statements of the  Guarantors  are not presented as we have
determined  them not to be  material  to  investors.  Therefore,  the  following
condensed consolidating financial information has been prepared using the equity
method of accounting in accordance  with the  requirements  for  presentation of
such  information.  We  believe  that  this  information,  presented  in lieu of
complete financial statements for each of the guarantor  subsidiaries,  provides
sufficient  detail to allow investors to determine the nature of the assets held
by, and the operations of, each of the consolidating groups.

<TABLE>
<CAPTION>

                                               Express                       Non-Guarantors
(in thousands)                              Scripts, Inc.     Guarantors                      Eliminations     Consolidated
<S>                                          <C>              <C>              <C>             <C>              <C>
- ------------------------------------------ ---------------- ---------------- --------------- ---------------- ----------------
As of December 31, 1999
Current assets                               $   549,374      $   506,976      $    10,005     $         -      $ 1,066,355
Property and equipment, net                       39,036           55,386            3,151               -           97,573
Investments in subsidiaries                      725,468                -          152,626        (727,729)         150,365
Intercompany                                     463,438         (388,760)         (74,678)              -                -
Goodwill, net                                        168          976,759            5,569               -          982,496
Other intangible assets, net                      22,458          160,901               61               -          183,420
Other assets                                      13,179              799           (6,729)           (147)           7,102
                                           ================ ================ =============== ================ ================
    Total assets                             $ 1,813,121      $ 1,312,061      $    90,005     $  (727,876)     $ 2,487,311
                                           ================ ================ =============== ================ ================

Current liabilities                          $   527,312      $   563,002      $    10,044     $         -      $ 1,100,358
Long-term debt                                   635,873                -                -               -          635,873
Other liabilities                                 83,365          (16,294)         (15,473)              -           51,598
Stockholders' equity                             566,571          765,353           95,434        (727,876)         699,482
                                           ---------------- ---------------- --------------- ---------------- ----------------
    Total liabilities and stockholders'
       equity                                $ 1,813,121      $ 1,312,061      $    90,005     $  (727,876)     $ 2,487,311
                                           ================ ================ =============== ================ ================

As of December 31, 1998
Current assets                               $   463,818      $   188,978      $     4,111     $         -      $   656,907
Property and equipment, net                       27,375           46,817            3,307               -           77,499
Investments in subsidiaries                       68,198           74,297              264        (142,759)               -
Intercompany                                     363,455         (361,202)          (2,253)              -                -
Goodwill, net                                        210          281,953                -               -          282,163
Other intangible assets, net                      11,770           53,884              111               -           65,765
Other assets                                       1,013           11,969              145               -           13,127
                                           ================ ================ =============== ================ ================
    Total assets                             $   935,839      $   296,696      $     5,685     $  (142,759)     $ 1,095,461
                                           ================ ================ =============== ================ ================

Current liabilities                          $   394,553      $   141,433      $     3,310     $         -      $   539,296
Long-term debt                                   306,000                -                -               -          306,000
Other liabilities                                    779             (251)             (57)              -              471
Stockholders' equity                             234,507          155,514            2,432        (142,759)         249,694
                                           ---------------- ---------------- --------------- ---------------- ----------------
    Total liabilities and stockholders'
       equity                                $   935,839      $   296,696      $     5,685     $  (142,759)     $ 1,095,461
                                           ================ ================ =============== ================ ================


Year ended December 31, 1999
Total revenues                               $ 2,257,952      $ 1,989,016      $    41,136     $         -      $ 4,288,104
Operating expenses                             2,140,144        1,943,207           67,969               -        4,151,320
                                           ---------------- ---------------- --------------- ---------------- ----------------
    Operating income (loss)                      117,808           45,809          (26,833)              -          136,784
Gain on sale of assets                                 -                -          182,930               -          182,930
Interest income (expense)                        (54,700)             292              160               -          (54,248)
                                           ---------------- ---------------- --------------- ---------------- ----------------
    Income before tax provision                   63,108           46,101          156,257               -          265,466
Income tax provision                              34,799           14,901           58,398               -          108,098
                                           ---------------- ---------------- --------------- ---------------- ----------------
    Income before extraordinary loss              28,309           31,200           97,859               -          157,368
Extraordinary loss                                 7,150                -                -               -            7,150
                                           ================ ================ =============== ================ ================
    Net Income                               $    21,159      $    31,200      $    97,859     $         -      $   150,218
                                           ================ ================ =============== ================ ================

Year ended December 31, 1998
Total revenues                               $ 1,646,807      $ 1,167,387      $    10,678     $         -      $ 2,824,872
Operating expenses                             1,584,731        1,139,387           11,520               -        2,735,638
                                           ---------------- ---------------- --------------- ---------------- ----------------
    Operating income (loss)                       62,076           28,000             (842)              -           89,234
Interest income (expense)                        (13,943)             846              103               -          (12,994)
                                           ---------------- ---------------- --------------- ---------------- ----------------
    Income (loss) before tax provision            48,133           28,846             (739)              -           76,240
Income tax provision                              17,903           15,377              286               -           33,566
                                           ================ ================ =============== ================ ================
    Net Income (loss)                        $    30,230      $    13,469      $    (1,025)    $         -      $    42,674
                                           ================ ================ =============== ================ ================

Year ended December 31, 1997
Total revenues                               $ 1,205,085      $    16,107      $     9,442     $         -      $ 1,230,634
Operating expenses                             1,158,490           15,031            8,263               -        1,181,784
                                           ---------------- ---------------- --------------- ---------------- ----------------
    Operating income                              46,595            1,076            1,179               -           48,850
Interest income (expense)                          5,821                -               35               -            5,856
                                           ---------------- ---------------- --------------- ---------------- ----------------
    Income before tax provision                   52,416            1,076            1,214               -           54,706
Income tax provision                              20,352              417              508               -           21,277
                                           ================ ================ =============== ================ ================
    Net Income                               $    32,064      $       659      $       706     $         -      $    33,429
                                           ================ ================ =============== ================ ================
</TABLE>

         The following  represents  the schedule of current  maturities  for our
long-term debt (in thousands):


Year Ended December 31,
- ---------------------------- -----------------------
2000                              $              -
2001                                        42,750
2002                                        57,000
2003                                        57,000
2004                                        62,700
                              =======================
                                  $        219,450
                              =======================

     To manage our  interest  rate risk we entered  into an  interest  rate swap
agreement ("swap") with The First National Bank of Chicago, a subsidiary of Bank
One Corporation, on April 3, 1998. At December 31, 1999 and 1998, the swap had a
notional principal amount of $306 million and $360 million, respectively.  Under
the terms of the swap,  we agreed to receive a floating  rate of interest on the
amount of the term loan facility  based on a three-month  LIBOR rate in exchange
for  payment  of a fixed  rate of  interest  of 5.88% per  annum.  The  notional
principal  amount of the swap began  amortizing  at $27  million in April  1999,
increasing to $36 million in April 2000, to $45 million in April 2001 and to $48
million in April 2002. As a result,  we have, in effect,  converted $306 million
of our variable rate debt under the Credit  Facility to fixed rate debt at 5.88%
per annum for the first  four years of the Credit  Facility,  plus the  interest
rate spread of 2.0%.

     On June 17, 1999,  we entered  into an interest  rate swap  agreement  with
Bankers Trust Company.  The swap will not become  effective until April 2000 and
carried no notional principal amount as of December 31, 1999. Under the terms of
the agreement,  we agreed to receive a floating rate of interest on the notional
principal amount based on a three-month  LIBOR rate in exchange for payment of a
fixed rate of interest of 6.25% per annum. Beginning in April 2000, the notional
principal  amount will be $15 million and will increase  semi-annually  up to an
approximate  $137 million in October 2002. For the remainder of the  agreement's
term,  the  notional   principal   amount  will  amortize  until  the  agreement
termination in April 2005. When the swap becomes effective,  we will, in effect,
convert the notional principal amount of our variable rate debt under our Credit
Facility to fixed rate debt at 6.25% per annum plus the interest rate spread.

     During 1999,  we entered  into an interest  rate lock with  Bankers'  Trust
Company  related to our offering of $250 million Senior Notes.  Upon issuance of
the Senior Notes, we received $2,135,000, which is being amortized over the term
of the Senior Notes. During 1999, interest expense was reduced by $116,000.

7.       Corporate restructuring

     During the  second  quarter of 1999,  we  recorded a pre-tax  restructuring
charge  of  $9,400,000  associated  with  the  consolidation  of  our  Plymouth,
Minnesota facility into our Bloomington,  Minnesota facility.  In December 1999,
the  associated  accrual was  reduced by  $2,301,000,  primarily  as a result of
subleasing a portion of the unoccupied  space. The  consolidation  plan includes
the  relocation  of all  employees at the Plymouth  facility to the  Bloomington
facility  that began in August  1999 and will end in the third  quarter of 2000.
Included  in the  restructuring  charge are  anticipated  cash  expenditures  of
approximately $4,823,000 for lease termination fees and rent on unoccupied space
(which  payments will continue  through April 2001,  when the lease expires) and
anticipated  non-cash charges of approximately  $2,276,000 for the write-down of
leasehold improvements and furniture and fixtures. The restructuring charge does
not include any costs associated with the physical relocation of the employees.

     During  December  1999,  we  recorded  a  pre-tax  restructuring  charge of
$2,633,000  associated with the  outsourcing of our computer  operations to EDS.
The principal  actions of the plan included cash  expenditures of  approximately
$2,148,000  for  the  transition  of 51  employees  to the  outsourcer  and  the
elimination of contractual  obligations of ValueRx which had no future  economic
benefit  to us,  and  non-cash  charges  of  approximately  $485,000  due to the
reduction  in the  carrying  value of certain  capitalized  software  to its net
realizable value. Completion of this plan will occur during the first quarter of
2000 when all cash payments will be made.

     Also in  December  1999,  we  recorded  a pre-tax  restructuring  charge of
$969,000 associated with restructuring our PPS majority-owned subsidiary and the
purchase of the remaining PPS Common Stock from management.  The charge consists
of cash  expenditures  of $559,000  relating to stock  compensation  expense and
$410,000 of severance payments to 9 employees (of which $133,000 was paid during
December 1999). This plan was completed in January 2000.

     During the  second  quarter of 1998,  we  recorded a pre-tax  restructuring
charge of $1,651,000  associated with closing the non-PBM service  operations of
its wholly-owned subsidiary, PhyNet, Inc., and transferring certain functions of
our Vision  Corporation to another vision care provider.  The restructuring plan
consisted  of $416,000  of cash  charges  associated  with the  severance  of 61
employees  and non-cash  charges of  $1,235,000  relating to the  write-down  of
long-lived assets no longer providing us benefit.  We completed the remainder of
the restructuring actions during the third quarter of 1999.

<TABLE>
<CAPTION>
                                                                   Balance at                                   Balance at
                                         1998          1998       December 31,        1999          1999       December 31,
(in thousands)                          Charges       Usage           1998         Additions       Usage           1999
<S>                                    <C>          <C>             <C>            <C>           <C>             <C>
- ------------------------------------- ------------ ------------- ---------------- ------------- ------------- ----------------
Non-cash
Write-down of long-lived assets        $    1,235   $      704      $      531     $    2,761    $    3,264      $       28
Cash
Employee transition costs                     416          184             232          2,558           365           2,425
Stock compensation                              -            -               -            559             -             559
Lease termination fees and rent                 -            -               -          4,823         4,318             505
                                      ============ ============= ================ ============= ============= ================
                                       $    1,651   $      888      $      763     $   10,701    $    7,947      $    3,517
                                      ============ ============= ================ ============= ============= ================
</TABLE>

     All of the  restructuring  charges  which  include  tangible  assets  to be
disposed  of are  written  down to their  net  realizable  value,  less  cost of
disposal.  We expect recovery to approximate its cost of disposal.  Considerable
management  judgment is necessary to estimate  fair value;  accordingly,  actual
results could vary from such estimates.


8.       Income taxes

         The income tax provision consists of the following:
<TABLE>
<CAPTION>
                                                   Year Ended December 31,
(in thousands)                                1999             1998            1997
<S>                                       <C>             <C>             <C>
- --------------------------------------------------------------------------------------
Current provision:
   Federal                                $   26,933      $   20,171      $   19,048
   State                                       4,190           3,049           2,779
   Foreign                                       758             278             284
                                       ---------------- --------------- --------------
      Total current provision                 31,881          23,498          22,111
                                       ---------------- --------------- --------------
Deferred provision:
   Federal                                    68,627           8,694            (714)
   State                                       7,590           1,374            (120)
                                       ---------------- --------------- --------------
      Total deferred provision                76,217          10,068            (834)
                                       ================ =============== ==============
Total current and deferred provision      $  108,098      $   33,566      $   21,277
                                       ================ =============== ==============
</TABLE>

         Income taxes included in the Consolidated Statement of Operations are:
<TABLE>
<CAPTION>
                                                          Year Ended December 31,
(in thousands)                                          1999          1998          1997
<S>                                                <C>           <C>            <C>
- --------------------------------------------------------------------------------------------
Continuing operations                              $  108,098    $   33,566     $   21,277
Extraordinary loss on early retirement of debt         (4,492)            -              -
                                                  ============== ============= =============
                                                   $  103,606        33,566         21,277
                                                  ============== ============= =============
</TABLE>

     A reconciliation of the statutory federal income tax rate and the effective
tax rate  follows  (the effect of foreign  taxes on the  effective  tax rate for
1999, 1998 and 1997 is immaterial):

<TABLE>
<CAPTION>
                                                   Year Ended December 31,
                                               1999        1998        1997
<S>                                            <C>         <C>         <C>
- --------------------------------------------------------------------------------
Statutory federal income tax rate              35.0%       35.0%       35.0%
State taxes, net of federal benefit             3.6         3.8         3.8
Non-deductible amortization of goodwill and
   customer contracts                           1.8         4.9         -
Other, net                                      0.3         0.3         0.1
                                              ==================================
Effective tax rate                             40.7%       44.0%       38.9%
                                              ==================================
</TABLE>

     The  deferred  tax assets and  deferred  tax  liabilities  recorded  in the
consolidated balance sheet are as follows:

<TABLE>
<CAPTION>
                                                               December 31,
(in thousands)                                            1999          1998
<S>                                                  <C>           <C>
- -------------------------------------------------------------------------------
Deferred tax assets:
   Allowance for bad debts                           $    5,744    $    8,013
   Inventory costing capitalization and reserves            185           684
   Accrued expenses                                      23,864        34,170
   Depreciation and property differences                  7,112         6,808
   Non-compete agreements                                 2,008           933
   Net operating loss carryforward                        7,829             -
   Unrealized loss on investments                         6,000             -
   Other                                                    508            17
                                                   ----------------------------
     Gross deferred tax assets                           53,250        50,625
Deferred tax liabilities:
   Gain on sale of assets                               (62,987)            -
   Goodwill and customer contract amortization           (7,942)            -
   Other                                                   (985)         (462)
                                                   ----------------------------
     Gross deferred tax liabilities                     (71,914)         (462)
                                                   ----------------------------

Net deferred tax (liabilities) assets                $  (18,664)   $   50,163
                                                   ============================
</TABLE>

9.       Commitments and contingencies

     We have entered into noncancellable  agreements to lease certain office and
distribution  facilities  with  remaining  terms from one to ten  years.  Rental
expense under the office and  distribution  facilities  leases in 1999, 1998 and
1997 was  $11,147,000,  $3,876,000  and  $2,272,000,  respectively.  The  future
minimum lease payments due under  noncancellable  operating leases is as follows
(in thousands):

<TABLE>
<CAPTION>

  Year Ended December 31,
<S>        <C>                  <C>
- -----------------------------------------------
           2000                 $     11,359
           2001                       10,653
           2002                        9,998
           2003                        9,806
           2004                        9,887
        Thereafter                    34,479
                            ===================
                                $     86,182
                            ===================
</TABLE>

     For  the  year  ended  December  31,  1999,   approximately  78.7%  of  our
pharmaceutical   purchases  were  through  one  wholesaler.   We  believe  other
alternative  sources are readily available and that no other concentration risks
exist at December 31, 1999.

     In the ordinary course of business  (which includes the business  conducted
by DPS and ValueRx  prior to acquiring  them on April 1, 1999 and April 1, 1998,
respectfully), various legal proceedings,  investigations or claims pending have
arisen against us and our  subsidiaries  (ValueRx and DPS continue to be a party
to  proceedings  that  arose  prior to their  April 1,  1998 and  April 1,  1999
respective  acquisition  dates). The effect of these actions on future financial
results is not subject to reasonable estimation because considerable uncertainty
exists  about  the  outcomes.   Nevertheless,   in  our  opinion,  the  ultimate
liabilities  resulting  from any such  lawsuits,  investigations  or claims  now
pending  are not  expected  to  materially  affect  our  consolidated  financial
position, results of operations, or cash flows.

10.      Employee benefit plans

     Retirement  savings  plan.  We  offer  all of  our  full-time  employees  a
retirement  savings  plan under  Section  401(k) of the Internal  Revenue  Code.
Employees may elect to enter a written salary  deferral  agreement under which a
maximum of 12% of their salary  (effective  January 1, 2000 maximum  deferral is
15%),  subject to aggregate limits required under the Internal Revenue Code, may
be  contributed  to the  plan.  We match  the  first  $2,000  of the  employee's
contribution for the year.  Effective January 1, 2000, we will match 100% of the
first 4% of the employees'  compensation  contributed to the Plan. For the years
ended  December  1999,  1998 and 1997, we made  contributions  of  approximately
$3,604,000, $1,751,000 and $909,000, respectively.

     Employee  stock  purchase  plan. In December  1998,  our Board of Directors
approved  an  employee  stock  purchase  plan,  effective  March 1,  1999,  that
qualifies  under  Section  423 of the  Internal  Revenue  Code and  permits  all
employees,  excluding certain management level employees,  to purchase shares of
our Class A Common Stock.  Participating employees may elect to contribute up to
10% of their  salary  to  purchase  common  stock  at the end of each six  month
participation  period at a purchase  price equal to 85% of the fair market value
of our Class A Common Stock at the end of the participation period. During 1999,
approximately  10,000  shares of our Class A Common  Stock were issued under the
plan. Class A Common Stock reserved for future employee purchases under the plan
is 240,000 at December 31, 1999.

     Deferred compensation plan. In December 1998, the Compensation Committee of
the Board of Directors approved a non-qualified  deferred compensation plan (the
"Executive  Deferred  Compensation  Plan"),  effective  January  1,  1999,  that
provides  benefits payable to eligible key employees at retirement,  termination
or death.  Benefit  payments are funded by a combination of  contributions  from
participants and us.  Participants  become fully vested in our  contributions on
the third  anniversary of the end of the plan year for which the contribution is
credited to their account.  For 1999, our annual contribution was equal to 6% of
each  participant's  total annual  compensation,  with 25% being invested in our
Class  A  Common  Stock  and the  remaining  being  allocated  to a  variety  of
investment  options.   As  a  result  of  the  implementation,   we  accrued  as
compensation  expense  $224,000 in 1999 and  $797,000 in 1998 as a past  service
contribution  which is  equal  to 8% of each  participant's  total  annual  cash
compensation  for the  period of the  participant's  past  service  with us in a
senior executive capacity. At December 31, 1999, 50,000 shares of Class A Common
Stock have been reserved for future plan contributions.

11.      Common stock

     The  holders  of Class A Common  Stock  have  one vote per  share,  and the
holders  of Class B Common  Stock have ten votes per  share.  NYLIFE  HealthCare
Management, Inc. ("NYLIFE HealthCare"),  an indirect subsidiary of New York Life
Insurance  Company,  is the sole  holder  our of Class B Common  Stock.  Class B
Common Stock converts into Class A Common Stock on a share-for-share  basis upon
transfer  (other than to New York Life or its  affiliates) and is convertible at
any  time  at the  discretion  of the  holder.  At  December  31,  1999,  NYLIFE
HealthCare   and  the  holders  of  Class  A  Common  Stock  have  control  over
approximately 86.2% and 13.8%, respectively, of the combined voting power of all
classes of Common Stock.

     In June 1999, we consummated our offering of 5,175,000  shares of our Class
A Common  Stock at a price of $61 per share.  The net  proceeds of  $299,378,000
were used to retire the $150 million senior  subordinated bridge credit facility
and a portion of the Term B loans under the $1.05 billion  credit  facility (see
Note 6).

     As of December 31, 1999, we had  repurchased  a total of 475,000  shares of
our Class A Common  Stock  under the  open-market  stock  repurchase  program we
announced on October 25, 1996, although no repurchases occurred during 1999. Our
Board of Directors approved the repurchase of up to 1,700,000 shares, and placed
no limit on the duration of the program.  Future  purchases,  if any, will be in
such  amounts  and at such times as we deem  appropriate  based upon  prevailing
market  and  business  conditions,  subject  to  certain  restrictions  on stock
repurchases  contained in our $1.05  billion  credit  facility and the Indenture
covering our Senior  Notes.  During 1999,  we used  approximately  10,000 shares
previously  purchased  under  this  program  to  satisfy  obligations  under our
employee stock option program (see Note 10).

     As of December 31,  1999,  approximately  10,555,000  shares of our Class A
Common Stock has been reserved for issuance to organizations  with which we have
signed  contractual  agreements (see Note 3) and for employee benefit plans (see
Note 10).

     In October 1998, we announced a two-for-one  stock split of our Class A and
Class B Common Stock for  stockholders of record on October 20, 1998,  effective
October 30,  1998.  The split was effected in the form of a dividend by issuance
of one additional share of Class A Common Stock for each share of Class A Common
Stock  outstanding  and one  additional  share of Class B Common  Stock for each
share of Class B Common  Stock  outstanding.  The  earnings  per  share  and the
weighted average number of shares outstanding for basic and diluted earnings per
share have been adjusted for the stock split except on the Consolidated  Balance
Sheet and the Consolidated Statement of Changes in Stockholders' Equity.

12.      Stock-based compensation plans

     At December 31, 1999, we had three fixed  stock-based  compensation  plans,
which are described below.

     In April 1992,  we adopted a stock option plan that we amended and restated
in 1995 and amended in 1999, which provides for the grant of nonqualified  stock
options and incentive  stock options to our officers and key employees  selected
by the Compensation Committee of the Board of Directors. Initially, a maximum of
1,400,000  shares of Class A Common Stock could be issued  under the plan.  That
amount increased to a maximum of 2,380,000  shares,  with no employee being able
to receive options to purchase more than 800,000 shares.

     In June 1994, the Board of Directors adopted the Express Scripts, Inc. 1994
Stock Option Plan,  also amended and restated in 1995 and amended in 1997,  1998
and 1999.  Reflecting  the  increase as of January 1, 2000, a total of 3,305,354
shares of our Class A Common Stock have been  reserved  for issuance  under this
plan.  That amount will increase  annually,  effective  January 1, commencing on
January 1, 2000 and  ending  January  1,  2004,  by 1% of our total  outstanding
shares of Class A and Class B Common Stock on such date.  Under either plan, the
exercise  price of the options may not be less than the fair market value of the
shares at the time of grant.  The  Compensation  Committee  has the authority to
establish  vesting  terms,  and typically  provides that the options vest over a
five-year period from the date of grant.  The options may be exercised,  subject
to a ten-year maximum, over a period determined by the Committee.

     In April  1992,  we also  adopted a stock  option plan that was amended and
restated  in 1995 and  amended in 1996 and 1999 that  provides  for the grant of
nonqualified stock options to purchase 48,000 shares to each director who is not
an employee of ours or our affiliates.  In addition, the second amendment to the
plan gave each non-employee  director who was serving in such capacity as of the
date of the second amendment the option to purchase 2,500 additional shares. The
second amendment options will vest over three years. A maximum of 384,000 shares
of Class A Common  Stock may be issued  under this plan at a price equal to fair
market value at the date of grant.  The plan provides that the options vest over
a two-,  three- or five-year  period from the date of grant  depending  upon the
circumstances of the grant.

     We apply APB 25 and related  interpretations  in accounting  for our plans.
Accordingly,  no  compensation  cost has been  recognized  for our stock options
plans.  Had  compensation  cost for our  stock  based  compensation  plans  been
determined  based on the fair value at the grant  dates for awards  under  those
plans  consistent  with the  method  prescribed  by FAS 123,  our net income and
earnings  per share would have been reduced to the pro forma  amounts  indicated
below.  Note that due to the adoption of the methodology  prescribed by FAS 123,
the pro forma results shown below only reflect the impact of options  granted in
1999, 1998 and 1997. Because future options may be granted and vesting typically
occurs over a five year period,  the pro forma  impact shown for 1999,  1998 and
1997 is not necessarily representative of the impact in future years.

<TABLE>
<CAPTION>

(in thousands, except per share data)          1999        1998       1997
<S>                                        <C>         <C>         <C>
- -------------------------------------------------------------------------------
Net income
   As reported                             $  150,218  $  42,674   $  33,429
   Pro forma                                  142,753     38,585      32,034

Basic earnings per share
   As reported                                 $ 4.16     $ 1.29      $ 1.02
   Pro forma                                     3.95       1.16        0.98

Diluted earnings per share
   As reported                                 $ 4.06     $ 1.27      $ 1.01
   Pro forma                                     3.86       1.14        0.97

</TABLE>

     The fair value of options  granted  (which is amortized to expense over the
option vesting period in determining the pro forma impact),  is estimated on the
date of grant using the  Black-Scholes  multiple  option-pricing  model with the
following weighted average assumptions:

<TABLE>
<CAPTION>
                                          1999            1998            1997
<S>                                    <C>             <C>            <C>
- --------------------------------------------------------------------------------
Expected life of option                2-7 years       2-7 years      2-7 years
Risk-free interest rate                 4.6-6.3%        4.1-5.9%       5.7-6.6%
Expected volatility of stock              59%             44%            40%
Expected dividend yield                   None            None           None

</TABLE>

     A summary  of the  status  of our  three  fixed  stock  option  plans as of
December 31, 1999,  1998 and 1997,  and changes during the years ending on those
dates is presented below.

<TABLE>
<CAPTION>
                                                  1999                         1998                         1997
                                    -------------------------------------------------------------------------------------------
                                                   Weighted-Average               Weighted-Average             Weighted-Average
                                                      Exercise                     Exercise Price                 Exercise
(share data in thousands)                Shares        Price             Shares      Price           Shares         Price
<S>                                          <C>       <C>               <C>       <C>                <C>       <C>
- -------------------------------------------------------------------------------------------------------------------------------
Outstanding at beginning of year             2,780     $ 28.02           1,702     $ 17.21            1,677     $ 12.56
Granted                                        843       60.43           1,866       40.65              602       22.78
Exercised                                    (196)       30.28           (133)       14.71            (529)        8.80
Forfeited/cancelled                          (141)       50.35           (655)       38.82             (48)       17.56
                                      =============               =============                 ============
Outstanding at end of year                   3,286       35.24           2,780       28.02            1,702       17.21
                                      =============               =============                 ============

Options exercisable at year end              1,391                         800                          641
Weighted-average fair value of
  Options granted during the year          $ 32.40                     $ 18.07                       $ 9.91

</TABLE>

     The following table  summarizes  information  about fixed stock options
outstanding at December 31, 1999:

<TABLE>
<CAPTION>
                                           Options Outstanding                                Options Exercisable
                       ------------------------------------------------------------    ----------------------------------

      Range of
   Exercise Prices           Number         Weighted-Average                                Number         Weighted-
   (share data in        Outstanding at        Remaining        Weighted-Average         Exercisable        Average
     thousands)             12/31/99        Contractual Life     Exercise Price          at 12/31/99     Exercise Price
<S>          <C>                    <C>                <C>                 <C>                  <C>              <C>
- ---------------------- ------------------- ------------------- --------------------    ----------------- ----------------
   $  3.25 - 16.50                  728                4.55                $11.74               643              $11.34
     17.00 - 28.41                  716                7.21                 22.60               341               21.20
     28.50 - 42.39                  683                8.27                 34.72               227               33.04
     51.63 - 55.13                  875                9.53                 53.00               110               55.13
     65.25 - 88.56                  284                9.34                 73.97                70               65.69
                       ===================                                             =================
   $  3.25 - 88.56                3,286                7.64                 35.24             1,391               23.50
                       ===================                                             =================

</TABLE>

13.      Segment information

     We are organized on the basis of services  offered and have determined that
we have two reportable  segments:  PBM services and non-PBM services (defined in
Note 1 "organization and operations").  We manage the pharmacy benefit within an
operating segment that encompasses a fully-integrated PBM service. The remaining
three operating  service lines (IVTx,  Specialty  Distribution  and Vision) have
been aggregated into a non-PBM reporting segment.

The following table presents  information about the reportable  segments for the
years ended December 31:

<TABLE>
<CAPTION>

(in thousands)                                    PBM        Non-PBM      Total
<S>                                          <C>             <C>      <C>
- --------------------------------------------------------- ------------ ---------
1999
Total revenues                               $4,222,294      $65,810  $4,288,104
Depreciation and amortization expense (1)        71,156          711      71,867
Interest income                                   5,761            1       5,762
Interest expense (1)                             60,001            9      60,010
Income before income taxes                      259,182        6,284     265,466
Total assets                                  2,479,746        7,565   2,487,311
Capital expenditures                             35,895        1,063      36,958
- --------------------------------------------------------- ------------ ---------
1998
Total revenues                               $2,765,111      $59,761  $2,824,872
Depreciation and amortization expense (1)        25,466          983      26,449
Interest income                                   7,235            1       7,236
Interest expense (1)                             20,218           12      20,230
Income before income taxes                       70,107        6,133      76,240
Total assets                                  1,068,715       26,746   1,095,461
Capital expenditures                             23,432          421      23,853
- --------------------------------------------------------- ------------ ---------
1997
Total revenues                               $1,191,173      $39,461  $1,230,634
Depreciation and amortization expense (1)         9,704          766      10,470
Interest income                                   6,080            1       6,081
Interest expense (1)                                209           16         225
Income before income taxes                       52,529        2,177      54,706
Total assets                                    385,330       17,178     402,508
Capital expenditures                             10,782        2,235      13,017
- --------------------------------------------------------- ------------ ---------
<FN>

(1) The  amortization  expense for deferred  financing  fees ($2,241 in 1999 and
    $609 in 1998) is included in interest expense on the Consolidated  Statement
    of Operations  and in  depreciation  and  amortization  on the  Consolidated
    Statement  of Cash Flows.  The  amortization  expense on stock  compensation
    expense ($77 in 1999) is included in  depreciation  and  amortization on the
    Consolidated  Statement of Operations and in stock  compensation  expense on
    the Consolidated Statement of Cash Flows.
</FN>
</TABLE>

14.      Quarterly financial data (unaudited)

<TABLE>
<CAPTION>

                                                                               Quarters
                                               -------------------------------------------------------------------------
(in thousands, except per share data)                First           Second(1)           Third            Fourth(2)
<S>                                                 <C>                <C>               <C>               <C>
- ---------------------------------------------- ------------------ ----------------- ----------------- ------------------
Fiscal 1999
Total revenues                                      $   899,087        $   996,749       $ 1,083,496       $ 1,308,772
Cost of revenues                                        823,647            869,989           958,987         1,174,282
Selling, general and administrative                      46,440             81,897            78,761            87,096
Operating income                                         29,000             35,463            45,748            26,573
  Extraordinary loss on early retirement of
    debt                                                      -             (6,597)             (553)                -
                                               ================== ================= ================= ==================
Net income                                          $    13,543        $       421       $    16,995       $   119,259
                                               ================== ================= ================= ==================

Basic earnings per share
  Before extraordinary item                         $     0.41         $     0.20        $     0.46        $     3.10
  Extraordinary loss on early retirement of
    debt                                                     -              (0.19)            (0.02)                -
                                               ================== ================= ================= ==================
  Net income                                        $     0.41         $     0.01        $     0.44        $     3.10
                                               ================== ================= ================= ==================

Diluted earnings per share
  Before extraordinary item                         $     0.40         $     0.20        $     0.45        $     3.03
  Extraordinary loss on early retirement of
    debt                                                     -              (0.19)            (0.02)                -
                                               ================== ================= ================= ==================
  Net income                                        $     0.40         $     0.01        $     0.43        $     3.03
                                               ================== ================= ================= ==================

<FN>

(1) Includes the  acquisition  of DPS effective  April 1, 1999.  Also includes a
    non-recurring  operating charge of $9,400 ($5,773 after tax). Excluding this
    amount, our basic and diluted earnings per share before  extraordinary items
    would have been $0.38 and $0.37, respectively.
(2) Includes  non-recurring  operating charges and a one time non operating gain
    of  $20,821   ($12,415  after  tax)  and  $182,903   ($112,037  after  tax),
    respectively.  Excluding these amounts,  our basic and diluted  earnings per
    share  before   extraordinary   items  would  have  been  $0.51  and  $0.50,
    respectively.
</FN>
</TABLE>

<TABLE>
<CAPTION>

                                                                               Quarters
                                               -------------------------------------------------------------------------
(in thousands, except per share data)                First           Second(1)           Third             Fourth
<S>                                                 <C>                <C>               <C>               <C>
- ---------------------------------------------- ------------------ ----------------- ----------------- ------------------
Fiscal 1998
Total revenues                                      $   371,362        $   807,406       $   807,319       $   838,784
Cost of revenues                                        338,492            743,557           738,544           764,403
Selling, general and administrative                      18,826             39,266            43,153            47,745
Operating income                                         14,044             22,932            25,622            26,636
                                               ================== ================= ================= ==================
Net income                                          $     9,878        $     9,568       $    11,303       $    11,924
                                               ================== ================= ================= ==================

Basic earnings per share                            $     0.30         $     0.29        $     0.34        $     0.36
                                               ================== ================= ================= ==================

Diluted earnings per share                          $     0.29         $     0.28        $     0.34        $     0.35
                                               ================== ================= ================= ==================
<FN>

(1) Includes the acquisition of ValueRx effective April 1, 1998. Also includes a
    non-recurring  operating charge of $1,651 ($1,002 after tax). Excluding this
    charge,  our basic and diluted  earnings per share would have been $0.32 and
    $0.31, respectively.
</FN>
</TABLE>

Item 9 - Changes in and Disagreements with Accountants on Accounting and
         Financial Disclosure

         None.

                                    PART III


Item 10 - Directors and Executive Officers of the Registrant

     The  information  required by this item will be  incorporated  by reference
from our definitive  Proxy Statement for our 2000 Annual Meeting of Stockholders
to be filed pursuant to Regulation 14A (the "Proxy Statement") under the heading
"I. Election of Directors";  provided that the Compensation  Committee Report on
Executive  Compensation  and  the  performance  graph  contained  in  the  Proxy
Statement shall not be deemed to be incorporated  herein;  and further  provided
that the information  regarding our executive  officers  required by Item 401 of
Regulation S-K has been included in Part I of this report.


Item 11 - Executive Compensation

     The  information  required by this item will be  incorporated  by reference
from  the  Proxy  Statement  under  the  headings   "Directors'   Compensation,"
"Compensation  Committee  Interlocks and Insider  Participation"  and "Executive
Compensation."


Item 12 - Security Ownership of Certain Beneficial Owners and Management

     The  information  required by this item will be  incorporated  by reference
from the Proxy  Statement  under the  headings  "Security  Ownership  of Certain
Beneficial Owners and Management."


Item 13 - Certain Relationships and Related Transactions

     The  information  required by this item will be  incorporated  by reference
from the Proxy Statement under the heading  "Certain  Relationships  and Related
Transactions."


                                     PART IV

Item 14 - Exhibits, Financial Statement Schedules and Reports on Form 8-K

(a)  Documents filed as part of this Report

     (1) Financial Statements

     The  following  report  of  independent  accountants  and our  consolidated
financial statements are contained in this Report on the page indicated

                                                          Page No. In
                                                           Form 10-K

  Report of Independent Accountants                           38

  Consolidated Balance Sheet as of
      December 31, 1999 and 1998                              39

  Consolidated Statement of Operations
      for the years ended December 31, 1999,
      1998 and 1997                                           40

  Consolidated Statement of Changes in
      Stockholders' Equity for the years ended
      December 31, 1999, 1998 and 1997                        41

  Consolidated Statement of Cash Flows for
      the years ended December 31, 1999,
      1998 and 1997                                           42

  Notes to Consolidated Financial Statements                  43

      (2) The following financial statement schedule is contained in this Report
on the page indicated.

                                                          Page No. In
Financial Statement Schedule:                             Form 10-K

      VIII.  Valuation and Qualifying Accounts
             and Reserves for the years ended
             December 31, 1997, 1998 and 1999                  68

        All other  schedules are omitted  because they are not applicable or the
required  information is shown in the consolidated  financial  statements or the
notes thereto.

      (3)  List of Exhibits

          See Index to Exhibits on pages 69 - 75

(b)  Reports on Form 8-K


  (i)      On  October  27,  1999,  we filed a  Current
           Report on Form 8-K,  dated  October 14, 1999
           under  Item 2 and  5,  regarding  our  asset
           contribution  and  reorganization  agreement
           with PlanetRx.com, Inc.

  (ii)     On  October  29,  1999,  we filed a  Current
           Report on Form 8-K,  dated  October 20, 1999
           under  Items  5 and  7,  regarding  a  press
           release  we  issued   concerning  our  third
           quarter 1999 financial performance.

  (iii)    On  December  16,  1999,  we filed a Current
           Report on Form 8-K,  dated December 16, 1999
           under Item 5 regarding a Dow Jones news wire
           issued  concerning  our  expected  growth in
           2000,   integration   progress   and   other
           matters.



                                   SIGNATURES

     Pursuant  to the  requirements  of  Section  13 or 15(d) of the  Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on
its behalf by the undersigned thereunto duly authorized.

                                  EXPRESS SCRIPTS, INC.


March 27, 2000                    By: /s/ Barrett A. Toan
                                      Barrett A. Toan, President
                                      and Chief Executive Officer


     Pursuant to the  requirements of the Securities  Exchange Act of 1934, this
report  has  been  signed  below  by the  following  persons  on  behalf  of the
registrant and in the capacities and on the dates indicated.

Signature                   Title                               Date


/s/ Barrett A. Toan         President,                          March 27, 2000
Barrett A. Toan             Chief Executive
                            Officer and Director

/s/ George Paz              Senior Vice President and           March 27, 2000
George Paz                  Chief Financial Officer


/s/ Joseph W. Plum          Vice President and                  March 27, 2000
Joseph W. Plum              Chief Accounting Officer


/s/ Howard I. Atkins        Director                            March 22, 2000
Howard I. Atkins


/s/ Stuart L. Bascomb       Executive Vice President -          March 27, 2000
Stuart L. Bascomb           Sales and Provider Relations
                            and Director


                            Director                            March __, 2000
Gary G. Benanav


/s/ Frank J. Borelli        Director                            March 22, 2000
Frank J. Borelli


/s/ Judith E. Campbell      Director                            March 21, 2000
Judith E. Campbell


/s/ Barbara B. Hill         Director                            March 21, 2000
Barbara B. Hill


/s/ Richard M. Kernan, Jr.  Director                            March 21, 2000
Richard M. Kernan, Jr.


/s/ Richard A. Norling      Director                            March 22, 2000
Richard A. Norling


/s/ Frederick J. Sievert    Director                            March 22, 2000
Frederick J. Sievert


/s/ Stephen N. Steinig      Director                             March 22, 2000
Stephen N. Steinig


                            Director                            March __, 2000
Seymour Sternberg


/s/ Howard L. Waltman       Director                            March 27, 2000
Howard L. Waltman


/s/ Gary E. Wendlant        Director                            March 22, 2000
Gary E. Wendlant


/s/ Norman Zachary          Director                            March 22, 2000
Norman Zachary



                              EXPRESS SCRIPTS, INC.
         Schedule VIII - Valuation and Qualifying Accounts and Reserves
                  Years Ended December 31, 1997, 1998 and 1999

<TABLE>
<CAPTION>
        Col. A                Col. B                     Col. C                     Col. D             Col. E
                                                        Additions
                                                       -----------
                              Balance           Charges          Charges                               Balance
                                at             to Costs         to Other                               at End
                             Beginning            and              and                                   of
      Description            of Period         Expenses         Accounts         (Deductions)          Period
<S>                        <C>              <C>              <C>                <C>                <C>
- ----------------------      -----------      ------------     ------------       ------------        ----------
Allowance for Doubtful
Accounts Receivable
Year Ended 12/31/97        $  2,335,145     $   3,680,409    $            -     $    1,213,991     $   4,801,563
Year Ended 12/31/98        $  4,801,563     $   4,583,008    $    9,570,069(1)  $    1,148,356     $  17,806,284
Year Ended 12/31/99        $ 17,806,284     $   4,989,041    $     (937,616)(2) $    4,576,997     $  17,280,712

<FN>

(1)  Represents the opening balance sheet for our April 1, 1998 acquisition of ValueRx.
(2)  Represents the opening balance sheet adjustment for ValueRx and the opening balance sheet for our April 1, 1999 acquisition of
     DPS.
</FN>
</TABLE>


                                INDEX TO EXHIBITS
            (Express Scripts, Inc. - Commission File Number 0-20199)


Exhibit
Number          Exhibit

2.1**          Stock  Purchase  Agreement  by and among  Columbia/HCA
               Healthcare Corporation,  VH Holdings,  Inc., Galen Holdings, Inc.
               and Express  Scripts,  Inc.,  dated as of February 19, 1998,  and
               certain related  Schedules,  incorporated by reference to Exhibit
               No. 2.1 to the Company's  Current  Report on Form 8-K filed March
               2, 1998.

2.2            First Amendment to Stock Purchase Agreement by and among
               Columbia/HCA  Healthcare  Corporation,  VH Holdings,  Inc., Galen
               Holdings,  Inc. and Express Scripts,  Inc., dated as of March 31,
               1998, and related  Exhibits  incorporated by reference to Exhibit
               No. 2.1 to the Company's  Current  Report on Form 8-K filed April
               14, 1998.

2.3**          Stock  Purchase  Agreement  by and  among  SmithKline
               Beecham  Corporation,   SmithKline  Beecham  InterCredit  BV  and
               Express Scripts,  Inc., dated as of February 9, 1999, and certain
               related  Schedules,  incorporated by reference to Exhibit No. 2.1
               to the Company's  Current  Report on Form 8-K filed  February 18,
               1999.

2.4            Asset  Contribution and  Reorganization  Agreement dated
               August 31, 1999 by and among  PlanetRx.com,  Inc.,  PRX Holdings,
               Inc., PRX Acquisition, Corp., YourPharmacy.com, Inc., and Express
               Scripts,  Inc.  (incorporated by reference to the Exhibit No. 2.1
               to  PlanetRx's  Registration  Statement  on Form S-1,  as amended
               (Registration Number 333-82485)).

3.1            Certificate of Incorporation of the Company, as amended,
               incorporated  by  reference  to Exhibit No. 3.1 to the  Company's
               Quarterly  Report on Form 10-Q for the  quarter  ending  June 30,
               1999.

3.2            Second  Amended and  Restated  Bylaws,  incorporated  by
               reference to Exhibit No. 3.3 to the Company's Quarterly Report on
               Form 10-Q for the quarter ending September 30, 1998.

4.1            Form  of   Certificate   for  Class  A  Common   Stock,
               incorporated  by  reference  to Exhibit No. 4.1 to the  Company's
               Registration  Statement  on Form  S-1  filed  June 9,  1992  (No.
               33-46974) (the "Registration Statement").

4.2            Indenture, dated as of June 16, 1999, among the Company,
               Bankers Trust Company, as trustee,  and Guarantors named therein,
               incorporated  by  reference  to Exhibit No. 4.4 to the  Company's
               Registration  Statement  on Form S-4  filed  August  4, 1999 (No.
               333-83133) (the "S-4 Registration Statement").

4.3*           Supplemental Indenture, dated as of October 6, 1999, to
               Indenture dated as of June 16, 1999,  among the Company,  Bankers
               Trust Company, as trustee, and Guarantors named therein.

4.4            Registration  Rights  Agreement,  dated  as of June 11,
               1999, among the Company,  Credit Suisse First Boston  Corporation
               and Deutsche Bank Securities  Inc.,  incorporated by reference to
               Exhibit No. 4.2 to the Company's S-4 Registration Statement.

10.1***        Stock Agreement  (Initial Shares) entered into as of
               December  31, 1995,  between the Company and American  Healthcare
               Purchasing Partners,  L.P.,  incorporated by reference to Exhibit
               No.  10.61 to the  Company's  Annual  Report on Form 10-K for the
               year ending 1995.

10.2***        Stock Agreement  (Membership Shares) entered into as
               of December 31, 1995, between the Company and American Healthcare
               Purchasing Partners,  L.P.,  incorporated by reference to Exhibit
               No.  10.62 to the  Company's  Annual  Report on Form 10-K for the
               year ending 1995.

10.3           Quota-Share Reinsurance Agreement executed as of August
               15,  1994,  between  New York Life  Insurance  Company  and Great
               Plains Reinsurance Company,  incorporated by reference to Exhibit
               10.1 to the  Company's  Quarterly  Report  on Form  10-Q  for the
               quarter ending September 30, 1994.

10.4           Amendment No. 1 to Quota-Share  Reinsurance  Agreement
               dated as of September 13, 1994,  between New York Life  Insurance
               Company and Great Plains  Reinsurance  Company,  incorporated  by
               reference to Exhibit 10.2 to the  Company's  Quarterly  Report on
               Form 10-Q for the quarter ending September 30, 1994.

10.5           Agreement  dated May 7, 1992,  between the Company and
               New York Life  Insurance  Company,  incorporated  by reference to
               Exhibit No. 10.26 to the Registration Statement.

10.6           Lease Agreement dated March 3, 1992, between Riverport,
               Inc.  and  Douglas  Development  Company--Irvine  Partnership  in
               commendam and the Company,  incorporated  by reference to Exhibit
               No. 10.21 to the Registration Statement.

10.7           First Amendment to Lease dated as of December 29, 1992,
               between Sverdrup/MDRC Joint Venture and the Company, incorporated
               by  reference  to Exhibit No.  10.13 to the  Company's  Quarterly
               Report on Form 10-Q for the quarter ending June 30, 1993.

10.8           Second  Amendment  to Lease  dated as of May 28,  1993,
               between Sverdrup/MDRC Joint Venture and the Company, incorporated
               by  reference  to Exhibit No.  10.14 to the  Company's  Quarterly
               Report on Form 10-Q for the quarter ending June 30, 1993.

10.9           Third Amendment to Lease entered into as of October 15,
               1993, by and between Sverdrup/MDRC Joint Venture and the Company,
               incorporated  by reference to Exhibit No. 10.69 to the  Company's
               Annual Report on Form 10-K for the year ending 1993.

10.10          Fourth  Amendment  to Lease dated as of March 24, 1994,
               by and  between  Sverdrup/MDRC  Joint  Venture  and the  Company,
               incorporated  by reference to Exhibit No. 10.70 to the  Company's
               Annual Report on Form 10-K for the year ending 1993.

10.11          Fifth Amendment to Lease made and entered into June 30,
               1994,  between  Sverdrup/MDRC  Joint  Venture  and  the  Company,
               incorporated  by  reference  to  Exhibit  10.1  to the  Company's
               Quarterly  Report on Form 10-Q for the  quarter  ending  June 30,
               1994.

10.12          Sixth  Amendment to Lease made and entered into January
               31, 1995,  between  Sverdrup/MDRC  Joint Venture and the Company,
               incorporated  by reference to Exhibit No. 10.70 to the  Company's
               Annual Report on Form 10-K for the year ending 1994.

10.13          Seventh Amendment to Lease dated as of August 14, 1998,
               by and between Duke Realty  Limited  Partnership,  by and through
               its general  partner,  Duke  Realty  Investments,  Inc.,  and the
               Company,  incorporated  by  reference  to Exhibit No. 10.3 to the
               Company's  Quarterly  Report on Form 10-Q for the quarter  ending
               September 30, 1998.

10.14          Eighth  Amendment to Lease dated as of August 14, 1998,
               by and between Duke Realty  Limited  Partnership,  by and through
               its general  partner,  Duke  Realty  Investments,  Inc.,  and the
               Company,  incorporated  by  reference  to Exhibit No. 10.4 to the
               Company's  Quarterly  Report on Form 10-Q for the quarter  ending
               September 30, 1998.

10.15          Ninth Amendment to Lease dated as of February 19, 1999,
               by and between Duke Realty  Limited  Partnership,  by and through
               its general  partner,  Duke  Realty  Investments,  Inc.,  and the
               Company,  incorporated  by  reference to Exhibit No. 10.29 to the
               Company's Annual Report on Form 10-K/A for the year ending 1998.

10.16          Single-Tenant  Lease-Net  entered  into as of June  30,
               1993, between James M. Chamberlain, Trustee of Chamberlain Family
               Trust dated September 21, 1979, and the Company,  incorporated by
               reference to Exhibit No. 10.16 to the Company's Form 10-Q for the
               quarter ending June 30, 1993.

10.17          First Amendment to Single-Tenant Lease-Net entered into
               as of November 12,  1993,  by and between  James M.  Chamberlain,
               Trustee  of   Chamberlain   Family   Trust,   and  the   Company,
               incorporated  by reference to Exhibit No. 10.74 to the  Company's
               Annual Report on Form 10-K for the year ending 1993.

10.18          Earth City Industrial  Office/Warehouse Lease Agreement
               dated as of August 19, 1996, by and between the Company and Louis
               Siegfried  Corporation,  incorporated by reference to Exhibit No.
               10.1 to the  Company's  Quarterly  Report  on Form  10-Q  for the
               quarter ending September 30, 1996.

10.19          Lease  Agreement  dated  as of June 12,  1989,  between
               Michael D.  Brockelman  and James S. Gratton,  as Trustees  under
               agreement  dated April 17, 1980, and Health Care Services,  Inc.,
               an indirect subsidiary of the Company,  incorporated by reference
               to Exhibit No.  10.7 to the  Company's  Quarterly  Report on Form
               10-Q for the quarter ending June 30, 1998.

10.20          Lease  Agreement  dated as of March 22,  1996,  between
               Ryan  Construction  Company  of  Minnesota,   Inc.,  and  ValueRx
               Pharmacy  Program,  Inc., an indirect  subsidiary of the Company,
               incorporated  by reference  to Exhibit No. 10.8 to the  Company's
               Quarterly  Report on Form 10-Q for the  quarter  ending  June 30,
               1998.

10.21          Lease  Extension  and Amendment  Agreement  dated as of
               July 24,  1998,  between  Faith A.  Griefen and ValueRx  Pharmacy
               Program,   Inc.,   an  indirect   subsidiary   of  the   Company,
               incorporated  by reference  to Exhibit No. 10.1 to the  Company's
               Quarterly  Report on Form 10-Q for the quarter  ending  September
               30, 1998.

10.22          Office Lease dated as of August 14, 1998 by and between
               Duke  Realty  Limited  Partnership,  by and  through  its general
               partner,   Duke  Realty  Investments,   Inc.,  and  the  Company,
               incorporated  by reference  to Exhibit No. 10.2 to the  Company's
               Quarterly  Report on Form 10-Q for the quarter  ending  September
               30, 1998.

10.23          Second Lease Amendment dated as of December 31, 1998 by
               and between Duke Realty Limited  Partnership,  by and through its
               general partner, Duke Realty Investments,  Inc., and the Company,
               incorporated  by reference to Exhibit No. 10.37 to the  Company's
               Annual  Report on Form  10-K/A for the year ending  December  31,
               1998.

10.24****      Express  Scripts,   Inc.  1992  Stock  Option  Plan,
               incorporated   by   reference   to  Exhibit  No.   10.23  to  the
               Registration Statement.

10.25****      Express  Scripts,  Inc. Stock Option Plan for Outside
               Directors,  incorporated by reference to Exhibit No. 10.24 to the
               Registration Statement.

10.26****      Express  Scripts,   Inc.  1994  Stock  Option  Plan,
               incorporated  by reference  to Exhibit No. 10.4 to the  Company's
               Quarterly  Report on Form 10-Q for the  quarter  ending  June 30,
               1994.

10.27****      Amended and  Restated  Express  Scripts,  Inc.  1992
               Employee Stock Option Plan,  incorporated by reference to Exhibit
               No.  10.78 to the  Company's  Annual  Report on Form 10-K for the
               year ending 1994.

10.28****      First Amendment to Express Scripts,  Inc. Amended and
               Restated  1992 Stock  Option Plan  incorporated  by  reference to
               Exhibit D to the Company's Proxy Statement dated April 22, 1999.

10.29****      Second Amendment to Express Scripts, Inc. Amended and
               Restated  1992 Stock  Option Plan  incorporated  by  reference to
               Exhibit F to the Company's Proxy Statement dated April 22, 1999.

10.30****      Amended and Restated  Express  Scripts,  Inc.  Stock
               Option Plan for Outside  Directors,  incorporated by reference to
               Exhibit No. 10.79 to the Company's Annual Report on Form 10-K for
               the year ending 1994.

10.31****      First Amendment to Express Scripts,  Inc. Amended and
               Restated   1992  Stock   Option   Plan  for   Outside   Directors
               incorporated  by  reference to Exhibit A to the  Company's  Proxy
               Statement dated April 9, 1996.

10.32****      Second Amendment to Express Scripts, Inc. Amended and
               Restated   1992  Stock   Option   Plan  for   Outside   Directors
               incorporated  by  reference to Exhibit G to the  Company's  Proxy
               Statement dated April 22, 1999.

10.33****      Amended and Restated Express Scripts, Inc. 1994 Stock
               Option Plan incorporated by reference to Exhibit No. 10.80 to the
               Company's Annual Report on Form 10-K for the year ending 1994.

10.34****      First Amendment to Express Scripts,  Inc. Amended and
               Restated  1994 Stock  Option Plan  incorporated  by  reference to
               Exhibit A to the Company's Proxy Statement dated April 16, 1997.

10.35****      Second Amendment to Express Scripts, Inc. Amended and
               Restated  1994 Stock  Option Plan  incorporated  by  reference to
               Exhibit A to the Company's Proxy Statement dated April 21, 1998.

10.36****      Third Amendment to Express Scripts,  Inc. Amended and
               Restated  1994 Stock  Option Plan,  incorporated  by reference to
               Exhibit C to the Company's Proxy Statement dated April 22, 1999.

10.37****      Fourth Amendment to Express Scripts, Inc. Amended and
               Restated  1994 Stock  Option Plan,  incorporated  by reference to
               Exhibit E to the Company's Proxy Statement dated April 22, 1999.

10.38****      Form of Severance  Agreement  dated as of January 27,
               1998, between the Company and each of the following  individuals:
               Stuart L. Bascomb, Thomas M. Boudreau,  Robert W. Davis, Linda L.
               Logsdon,  David A.  Lowenberg,  George  Paz,  Terrence  D.  Arndt
               (agreement dated as of May 26, 1999), Mabel Chen (agreement dated
               as of Novemebr 23, 1999) and Mark O. Johnson  (agreement dated as
               of May 26, 1999)  incorporated  by reference to Exhibit No. 10.70
               to the  Company's  Annual Report on Form 10-K for the year ending
               December 31, 1997.

10.41          Senior  Subordinated Credit Agreement dated as of April
               1, 1999 among the Company,  the Lenders  listed  therein,  Credit
               Suisse First Boston,  as Lead Arranger and  Administrative  Agent
               and BT Alex. Brown Incorporated, as Co-Arranger,  incorporated by
               reference to Exhibit No. 10.6 to the Company's  Quarterly  Report
               on Form 10-Q for the quarter ending June 30, 1999.

10.42          Senior  Subordinated  Subsidiary  Guaranty  dated as of
               April  1,  1999,  in favor  of  Credit  Suisse  First  Boston  as
               Administrative  Agent  and  the  Lenders  listed  in  the  Senior
               Subordinated Credit Agreement, by the following parties:  Managed
               Prescription  Network,  Inc.,  Value Health,  Inc.,  IVTx,  Inc.,
               Express  Scripts  Vision Corp.,  ESI/VRx Sales  Development  Co.,
               HealthCare  Services,  Inc., MHI, Inc.,  ValueRx,  Inc.,  ValueRx
               Pharmacy  Program,  Inc.,  Diversified  Pharmaceutical  Services,
               Inc.,  incorporated  by  reference  to  Exhibit  No.  10.7 to the
               Company's  Quarterly  Report on Form 10-Q for the quarter  ending
               June 30, 1999.

10.43          Credit  Agreement  dated as of April 1, 1999  among the
               Company,  the Lenders listed therein,  Credit Suisse First Boston
               as lead  Arranger,  Administrative  Agent and  Collateral  Agent,
               Bankers Trust Company as Syndication  Agent,  BETWEEN Alex. Brown
               Incorporated as  Co-Arranger,  The First National Bank of Chicago
               as   Co-Documentation   Agent,   and  Mercantile  Bank,  N.A.  as
               co-Documentation Agent,  incorporated by reference to Exhibit No.
               10.8 to the  Company's  Quarterly  Report  on Form  10-Q  for the
               quarter ending June 30, 1999.

10.44          Amendment No.1 to Credit Agreement dated as of April 1,
               1999 among the Company, the Lenders listed therein, Credit Suisse
               First Boston as Lead Arranger,  Administrative Agent and BT Alex.
               Brown  Incorporated  as  Co-Arranger,  The First National Bank of
               Chicago as  Co-Documentation  Agent, and Mercantile Bank, N.A. as
               Co-Documentation Agent,  incorporated by reference to Exhibit No.
               10.1 to the  Company's  Quarterly  Report  on Form  10-Q  for the
               quarter ending September 30, 1999.

10.45          Amendment  No. 2 to Credit  Agreement dated as of April
               1, 1999 among the Company,  the Lenders  listed  therein,  Credit
               Suisse First Boston as Lead  Arranger,  Administrative  Agent and
               Collateral Agent,  Bankers Trust Company as Syndication Agent, BT
               Alex. Brown Incorporated as Co-Arranger,  The First National Bank
               of Chicago as  Co-Documentation  Agent, and Mercantile Bank, N.A.
               as Co-Documentation  Agent,  incorporated by reference to Exhibit
               No. 10.2 to the Company's  Quarterly  Report on Form 10-Q for the
               quarter ending September 30, 1999.

10.46          Amendment No. 3 and Waiver to Credit Agreement dated as
               of April 1, 1999 among the Company,  the Lenders listed  therein,
               Credit Suisse First Boston as Lead Arranger, Administrative Agent
               and Collateral Agent, Bankers Trust Company as Syndication Agent,
               BT Alex.  Brown  Incorporated as Co-Arranger,  The First National
               Bank of Chicago as  Co-Documentation  Agent, and Mercantile Bank,
               N.A. as  Co-Documentation  Agent,  incorporated  by  reference to
               Exhibit No. 10.3 to the Company's  Quarterly  Report on Form 10-Q
               for the quarter ending September 30, 1999.

10.47          Subsidiary Guaranty dated as of April 1, 1999, in favor
               of Credit Suisse First Boston as Collateral Agent and the Lenders
               listed in the Credit Agreement, by the following parties: Managed
               Prescription  Network,  Inc.,  Value Health,  Inc.,  IVTx,  Inc.,
               Express  Scripts  Vision Corp.,  ESI/VRx Sales  Development  Co.,
               HealthCare  Services,  Inc., MHI, Inc.,  ValueRx,  Inc.,  ValueRx
               Pharmacy  Program,  Inc.,  Diversified  Pharmaceutical  Services,
               Inc., ESI OnLine, Inc.,  incorporated by reference to Exhibit No.
               10.9 to the  Company's  Quarterly  Report  on Form  10-Q  for the
               quarter ending June 30, 1999.

10.48          Company  Pledge Agreement dated as of April 1, 1999, by
               the Company in favor of Credit  Suisse First Boston as Collateral
               Agent  and  the   Lenders   listed  in  the   Credit   Agreement,
               incorporated  by reference to Exhibit No. 10.10 to the  Company's
               Quarterly  Report on Form 10-Q for the  quarter  ending  June 30,
               1999.

10.49          Subsidiary  Pledge  Agreement  dated as of April 1, 1999, in
               favor of Credit Suisse First Boston as  Collateral  Agent and the
               Lenders listed in the Credit Agreement, by the following parties:
               ESI Canada Holdings,  Inc., Value Health,  Inc.,  ValueRx,  Inc.,
               incorporated  by reference to Exhibit No. 10.11 to the  Company's
               Quarterly  Report on Form 10-Q for the  quarter  ending  June 30,
               1999.

10.50          International  Swap Dealers  Association,  Inc.  Master
               Agreement dated as of April 3, 1998,  between the Company and The
               First  National  Bank of Chicago,  incorporated  by  reference to
               Exhibit No. 10.6 to the Company's  Quarterly  Report on Form 10-Q
               for the quarter ending June 30, 1998.

10.51          Swap  Transaction  Confirmation  Agreement  between the
               Company  and  Bankers   Trust   Company   dated  June  17,  1999,
               incorporated  by reference  to Exhibit No. 10.5 to the  Company's
               Quarterly  Report on Form 10-Q for the quarter  ending  September
               30, 1999.

10.52****      Express  Scripts,  Inc.  Employee Stock Purchase Plan
               incorporated  by  reference  to Exhibit No. 4.1 to the  Company's
               Registration Statement on Form S-8 filed December 29, 1998.

10.53****      Express Scripts, Inc. Executive Deferred Compensation
               Plan  incorporated  by  reference  to  Exhibit  No.  4.1  to  the
               Company's  Registration  Statement on Form S-8 filed February 16,
               1999.

10.54****      Employment  Agreement  effective as of April 1, 1999,
               between  Barrett  A.  Toan  and  the  Company,   incorporated  by
               reference to Exhibit No. 10.1 to the Company's  Quarterly  Report
               on Form 10-Q for the quarter ending March 31, 1999.

10.55          Agreement  dated  August 31, 1999 by and among  Express
               Scripts, Inc. and PlanetRx.com,  Inc., including form of Provider
               Agreement,  incorporated  by reference to Exhibit No. 10.1 to the
               Company's  Current  Report on Form 8-K  dated  October  14,  1999
               (filed on October 27, 1999).

10.56          Amended and Restated  Investor's Rights Agreement dated
               as of June 3, 1999, (incorporated by reference to the Exhibit No.
               4.2 to PlanetRx's  Registration Statement on Form S-1, as amended
               (Registration Number 333-82485)).

10.57          Amendment  of Amended and  Restated  Investor's  Rights
               Agreement   dated  as  of  October   13,   1999  by  and  between
               PlanetRx.com,  Inc. and YourPharmacy.com,  Inc.  (incorporated by
               reference  to Exhibit 4 to  Schedule  13D dated  October 21, 1999
               filed  October 22,  1999)  filed by Express  Scripts,  Inc.  with
               respect to PlanetRx.com, Inc. (File No. 000-27437).

12.1*          Computation of Ratios of Earnings to Fixed Charges.

21.1*          List of Subsidiaries.

23.1*          Consent of PricewaterhouseCoopers LLP.

27.1*          Financial Data Schedule  (provided for the information
               of the U.S. Securities and Exchange Commission only).



*    Filed herein.
**   The Company agrees to furnish  supplementally  a copy of any omitted
     schedule to this agreement to the Commission upon request.
***  Confidential treatment granted for certain portions of these exhibits.
**** Management contract or compensatory plan or arrangement.




                                   EXHIBIT 4.3


                              EXPRESS SCRIPTS, INC.
                                    as Issuer

                        THE GUARANTORS as defined herein
                                  as Guarantors

                                       and

                              BANKERS TRUST COMPANY
                                   as Trustee

                                  $250,000,000

                          9 5/8% SENIOR NOTES DUE 2009

                        --------------------------------

                             SUPPLEMENTAL INDENTURE

                           Dated as of October 6, 1999

                                       to

                                    INDENTURE

                            Dated as of June 16, 1999

                        --------------------------------


     SUPPLEMENTAL INDENTURE (this "Supplemental Indenture"), dated as of October
6, 1999, among Express Scripts, Inc. (the "Company"), the Guarantors as named in
the  Indenture  (as defined  herein),  and Bankers Trust Company as trustee (the
"Trustee").

     WHEREAS,  the Company  and the  Guarantors  have  heretofore  executed  and
delivered  to the  Trustee an  Indenture  dated as of June 16,  1999,  among the
Company,  the  Guarantors  and  the  Trustee  (the  "Indenture"),   relating  to
$250,000,000  aggregate  principal  amount at maturity  of the  Company's 9 5/8%
Senior Notes due 2009 (the "Notes");

     WHEREAS,  pursuant to Section  9.02 of the  Indenture,  the Company and the
Guarantors have requested to amend the Indenture and have received the requisite
consents of the Holders of the outstanding Notes to the amendments made hereby;

     WHEREAS,  the Company and each of the  Guarantors  are  authorized to enter
into this Supplemental  Indenture by resolution of the Board of Directors of the
Company or such Guarantor;

     WHEREAS, the Company has delivered an Officers'  Certificate and Opinion of
Counsel to the Trustee pursuant to Section 9.06 of the Indenture; and

     WHEREAS, all other actions necessary to make this Supplemental  Indenture a
legal, valid and binding obligation of the parties hereto in accordance with its
terms and the terms of the Indenture have been performed;

     NOW,  THEREFORE,  in consideration of the promises contained herein and for
other good and valuable  consideration,  the receipt and sufficiency of which is
hereby acknowledged, the Company, the Guarantors and the Trustee hereby mutually
covenant and agree for the equal and proportionate benefit of all Holders of the
Notes as follows:

                                    ARTICLE I
                                   AMENDMENTS

     Upon execution and effectiveness of this Supplemental Indenture,  the terms
of the Notes and the Indenture shall be amended as follows:

     SECTION I.1. Section 1.01 of the Indenture shall be amended as follows:

     (a) by deleting clause (viii) of the definition of "Asset  Disposition" and
substituting in lieu thereof the following:

     "(viii) a disposition  of any Capital Stock or assets of  YourPharmacy.com,
Inc. or any corporation,  partnership or limited  liability company which is the
successor to the business  conducted or  contemplated  to be conducted as of the
Issue Date by YourPharmacy.com, Inc.;" and

     (b) by deleting  clause (vi) of the  definition of "Permitted  Investments"
and substituting in lieu thereof the following:

     "(vi)Investments  made by the Company or its Restricted  Subsidiaries  as a
          result  of   consideration   received  in  connection  with  an  Asset
          Disposition made in compliance with, or a disposition of assets exempt
          from, Section 4.15;".

                                   ARTICLE II
                                  MISCELLANEOUS

     SECTION II.1. For all purposes of this  Supplemental  Indenture,  except as
otherwise herein expressly  provided or unless the context  otherwise  requires:
(A) the terms and  expressions  used  herein  shall  have the same  meanings  as
corresponding  terms and  expressions  used in the  Indenture  and (B) the words
"herein,"  "hereof" and "hereby" and other words of similar  import used in this
Supplemental  Indenture refer to this Supplemental  Indenture as a whole and not
any particular Article, Section or other subdivision.

     SECTION II.2.  Upon the  effectiveness  of this Supplement  Indenture,  the
Indenture  shall be modified in  accordance  herewith,  but except as  expressly
amended hereby,  the Indenture is in all respects ratified and confirmed and all
the terms,  conditions  and  provisions  thereof  shall remain in full force and
effect.

     SECTION II.3. Upon effectiveness,  this Supplemental Indenture shall form a
part of the Indenture and the Supplemental  Indenture and the Indenture shall be
read,  taken and construed as one and the same instrument for all purposes,  and
every holder of Notes heretofore or hereafter  authenticated and delivered under
the Indenture shall be bound hereby.

     SECTION  II.4.  This   Supplemental   Indenture   shall  become   effective
immediately   prior  to  the   contribution  of  certain   specified  assets  of
YourPharmacy.com,  Inc. ("YPC"),  a wholly-owned  subsidiary of the Company,  to
PlanetRx.com,  Inc.  ("PlanetRx")  in  exchange  for  common  stock of  PlanetRx
pursuant  to  the  agreement  between   PlanetRx,   YPC  and  the  Company  (the
"Transaction").  If the  Transaction  does not  occur,  then  this  Supplemental
Indenture will not become effective and will be void.

     SECTION II.5. The Trustee  accepts the amendment to the Indenture  effected
by this  Supplemental  Indenture  and agrees to execute the trust created by the
Indenture,  as hereby amended,  but only upon the terms and conditions set forth
in the Indenture, as hereby amended, including the terms and provisions defining
and limiting the liabilities and  responsibilities  of the Trustee,  which terms
and provisions  shall in like manner define and limit the Trustee's  liabilities
in the  performance  of the trust created by the Indenture,  as hereby  amended.
Without   limiting  the  generality  of  the  foregoing,   the  Trustee  has  no
responsibility  for the  correctness  of the  recitals of fact herein  contained
which  shall  be  taken  as  the   statements   of  the  Company  and  makes  no
representations   as  to  the  validity  or  sufficiency  of  this  Supplemental
Indenture,  except as to the due and valid execution hereof by the Trustee,  and
shall incur no liability or  responsibility  in respect of the validity thereof.
The Trustee's  execution of this Supplemental  Indenture should not be construed
to be an approval or  disapproval of the  advisability  of the amendments to the
Indenture provided herein.

     SECTION  II.6.  THIS  SUPPLEMENTAL  INDENTURE  SHALL BE  GOVERNED  BY,  AND
CONSTRUED IN ACCORDANCE  WITH,  THE LAWS OF THE STATE OF NEW YORK  APPLICABLE TO
AGREEMENTS MADE AND TO BE PERFORMED ENTIRELY IN SAID STATE.

     SECTION II.7. This Supplemental  Indenture may be executed in any number of
counterparts,  each of which when so executed shall be deemed to be an original,
and  all of such  counterparts  shall  together  constitute  one  and  the  same
instrument.

     IN WITNESS  WHEREOF,  the parties  hereto  have  caused  this  Supplemental
Indenture to be duly executed as of the day and year first above written.


                                   EXPRESS SCRIPTS, INC.

                                   By:  /s/ Barrett Toan
                                      Name: Barrett Toan
                                      Title: President

                                   DIVERSIFIED  PHARMACEUTICAL
                                   SERVICES,   INC.,   ESI/VRX
                                   SALES    DEVELOPMENT   CO.,
                                   EXPRESS    SCRIPTS   VISION
                                   CORPORATION,   IVTX,  INC.,
                                   MANAGED  PRESCRIPTION
                                   NETWORK,  INC.,  MHI, INC.,
                                   VALUE     HEALTH,     INC.,
                                   VALUERX,    INC.,   VALUERX
                                   PHARMACY   PROGRAM,   INC.,
                                   YOURPHARMACY.COM,     INC.,
                                   HEALTH CARE SERVICES, INC.

                                   By: /s/ Barrett Toan
                                        Name: Barrett Toan
                                        Title:President

                                  BANKERS TRUST COMPANY, as Trustee

                                  By: /s/ Susan Johnson
                                        Name: Susan Johnson
                                        Title:Assistant Vice President



                                  EXHIBIT 12.1
                              EXPRESS SCRIPTS, INC.
                STATEMENT OF RATIOS OF EARNINGS TO FIXED CHARGES
            YEARS ENDED DECEMBER 31, 1999, 1998, 1997, 1996 AND 1995



<TABLE>
<CAPTION>
                                                                   Year Ended December 31,
                                          --------------------------------------------------------------------------
(in thousands)                               1999            1998           1997            1996           1995
<S>                <C>                     <C>             <C>            <C>             <C>            <C>
                                          ------------    ------------   ------------    ------------   ------------

Fixed charges:
  Interest expense (1)                     $  60,010       $  20,230      $     225       $      59      $      86
  Interest portion of rental expense           3,716           1,292            757             700            627
                                          ------------    ------------   ------------    ------------   ------------
    Total fixed charges                       63,726          21,522            982             759            713

Earnings:
  Income before income taxes and
    extraordinary items (2)                  265,466          76,240         54,706          43,080         29,634

                                          ============    ============   ============    ============   ============
Total adjusted earnings                    $ 329,192       $  97,762      $  55,688       $  43,839      $  36,347
                                          ============    ============   ============    ============   ============

Ratio of earnings to fixed charges              5.17            4.54          56.71           57.76          42.56
                                          ============    ============   ============    ============   ============

<FN>

     (1)  Interest expense  includes the amortization on our deferred  financing
          fees.

     (2)  Income  before   income  taxes  and   extraordinary   items   includes
          non-recurring charges and a one-time gain on sale of assets.
</FN>
</TABLE>




                                  Exhibit 21.1

Subsidiary                               State of Incorporatio   D/B/A
Diversified NY IPA, Inc.                 New York                None
Diversified Pharmaceutical Services
   (Puerto Rico), Inc.                   Puerto Rico             None
Diversified Pharmaceutical Services,
   Inc.                                  Minnesota               None
ESI Canada Holdings, Inc.                New Brunswick, Canada   None
ESI Canada, Inc.                         New Brunswick, Canada   None
ESI Claims, Inc.                         Delaware                None
ESI Mail Pharmacy Services, Inc.         Delaware                None
ESI Utilization Management Co.           Delaware                None
Express Scripts Sales Development Co.    Delaware                None
Express Scripts Specialty Distribution
   Services, Inc.                        Delaware                None
Express Scripts Vision Corporation       Delaware                ESI Vision Care
IVTx, Inc.                               Delaware                Express Scripts
                                                                 Infusion
                                                                 Services
Great Plains Reinsurance Company         Arizona                 None
Practice Patterns Science, Inc.          Delaware                None
Value Health, Inc.                       Delaware                None
ValueRx of Michigan, Inc.                Michigan                None
YourPharmacy.com, Inc.                   Delaware                None
607486 Alberta Ltd.                      Albert, Canada          None



                                  Exhibit 23.1

                       Consent of Independent Accountants

     We hereby  consent to the  incorporation  by reference in the  Registration
Statements on Form S-3 (No. 333-74613) and Form S-8 (Nos. 333-80255,  333-72441,
333-69855,  333-48779,  333-48767,  333-48765,  333-27983,  333-04291, 33-64094,
33-64278,  33-93106) of Express  Scripts,  Inc. of our report dated  February 4,
2000,  relating to the financial  statements and financial  statement  schedule,
which appears in this Form 10-K.


/s/ PricewaterhouseCoopers LLP
PricewaterhouseCoopers LLP
St. Louis, Missouri
March 27, 2000


<TABLE> <S> <C>


<ARTICLE>                     5

<CIK>                         0000885721
<NAME>                        Express Scripts, Inc.
<MULTIPLIER>                                   1,000
<CURRENCY>                                     U.S. Dollars

<S>                             <C>
<PERIOD-TYPE>                   12-Mos
<FISCAL-YEAR-END>                              DEC-31-1999
<PERIOD-START>                                 JAN-01-1999
<PERIOD-END>                                   SEP-30-1999
<EXCHANGE-RATE>                                1
<CASH>                                         132,630
<SECURITIES>                                   0
<RECEIVABLES>                                  800,367
<ALLOWANCES>                                   17,281
<INVENTORY>                                    113,248
<CURRENT-ASSETS>                               1,066,355
<PP&E>                                         147,180
<DEPRECIATION>                                 49,607
<TOTAL-ASSETS>                                 2,487,311
<CURRENT-LIABILITIES>                          1,100,358
<BONDS>                                        635,873
                          0
                                    0
<COMMON>                                       390
<OTHER-SE>                                     699,092
<TOTAL-LIABILITY-AND-EQUITY>                   2,487,311
<SALES>                                        4,285,104
<TOTAL-REVENUES>                               4,288,104
<CGS>                                          3,826,905
<TOTAL-COSTS>                                  4,151,320
<OTHER-EXPENSES>                               0
<LOSS-PROVISION>                               0
<INTEREST-EXPENSE>                             60,010
<INCOME-PRETAX>                                265,466
<INCOME-TAX>                                   108,098
<INCOME-CONTINUING>                            157,368
<DISCONTINUED>                                 0
<EXTRAORDINARY>                                7,150
<CHANGES>                                      0
<NET-INCOME>                                   150,218
<EPS-BASIC>                                  4.16
<EPS-DILUTED>                                  4.06




</TABLE>


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