<PAGE>
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
(Rule 13d-102)
INFORMATION TO BE INCLUDED IN STATEMENTS
FILED PURSUANT TO RULES 13D-1 (b) AND (c)
AND AMENDMENTS THERETO FILED
PURSUANT TO 13d-2(b)
(Amendment No. )*
Leukosite, Inc.
- --------------------------------------------------------------------------------
(Name of Issuer)
Common Stock, $.01 par value
- --------------------------------------------------------------------------------
(Title of Class of Securities)
52728R102
------------------------------------
(CUSIP Number)
* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
(Continued on following page(s))
Page 1 of 15 Pages
<PAGE>
________________________________________________________________________________
CUSIP No. 52728R102 13G Page 2 of 15 Pages
________________________________________________________________________________
1 | NAME OF REPORTING PERSON
| S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
|
| HealthCare Ventures III, L.P.
________|_______________________________________________________________________
2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
| (b) [ ]
________|_______________________________________________________________________
3 | SEC USE ONLY
________|_______________________________________________________________________
4 | CITIZENSHIP OR PLACE OF ORGANIZATION
| Delaware
________|_______________________________________________________________________
| |
| 5 | SOLE VOTING POWER
| |
|_____|__________________________________________________________
NUMBER OF | |
SHARES | 6 | SHARED VOTING POWER
BENEFICIALLY | | 1,545,944
OWNED BY |_____|__________________________________________________________
EACH | |
REPORTING | 7 | SOLE DISPOSITIVE POWER
PERSON WITH | |
|_____|__________________________________________________________
| |
| 8 | SHARED DISPOSITIVE POWER
| | 1,545,944
_______________|_____|__________________________________________________________
9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
| 1,545,944
_______|________________________________________________________________________
10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
| CERTAIN SHARES* [ ]
_______|________________________________________________________________________
11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9
| 17.8%
_______|________________________________________________________________________
12 | TYPE OF REPORTING PERSON*
| PN
_______|________________________________________________________________________
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
________________________________________________________________________________
CUSIP No. 52728R102 13G Page 3 of 15 Pages
________________________________________________________________________________
1 | NAME OF REPORTING PERSON
| S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
|
| HealthCare Partners III, L.P.
________|_______________________________________________________________________
2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
| (b) [ ]
________|_______________________________________________________________________
3 | SEC USE ONLY
________|_______________________________________________________________________
4 | CITIZENSHIP OR PLACE OF ORGANIZATION
| Delaware
________|_______________________________________________________________________
| |
| 5 | SOLE VOTING POWER
| |
|_____|__________________________________________________________
NUMBER OF | |
SHARES | 6 | SHARED VOTING POWER
BENEFICIALLY | | 1,545,944
OWNED BY |_____|__________________________________________________________
EACH | |
REPORTING | 7 | SOLE DISPOSITIVE POWER
PERSON WITH | |
|_____|__________________________________________________________
| |
| 8 | SHARED DISPOSITIVE POWER
| | 1,545,944
_______________|_____|__________________________________________________________
9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
| 1,545,944
_______|________________________________________________________________________
10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
| CERTAIN SHARES* [ ]
_______|________________________________________________________________________
11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9
| 17.8%
_______|________________________________________________________________________
12 | TYPE OF REPORTING PERSON*
| PN
_______|________________________________________________________________________
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
________________________________________________________________________________
CUSIP No. 52728R102 13G Page 4 of 15 Pages
________________________________________________________________________________
1 | NAME OF REPORTING PERSON
| S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
|
| HealthCare Ventures IV, L.P.
________|_______________________________________________________________________
2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
| (b) [ ]
________|_______________________________________________________________________
3 | SEC USE ONLY
________|_______________________________________________________________________
4 | CITIZENSHIP OR PLACE OF ORGANIZATION
| Delaware
________|_______________________________________________________________________
| |
| 5 | SOLE VOTING POWER
| |
|_____|__________________________________________________________
NUMBER OF | |
SHARES | 6 | SHARED VOTING POWER
BENEFICIALLY | | 453,982
OWNED BY |_____|__________________________________________________________
EACH | |
REPORTING | 7 | SOLE DISPOSITIVE POWER
PERSON WITH | |
|_____|__________________________________________________________
| |
| 8 | SHARED DISPOSITIVE POWER
| | 453,982
_______________|_____|__________________________________________________________
9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
| 453,982
_______|________________________________________________________________________
10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
| CERTAIN SHARES* [ ]
_______|________________________________________________________________________
11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9
| 5.2%
_______|________________________________________________________________________
12 | TYPE OF REPORTING PERSON*
| PN
_______|________________________________________________________________________
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
________________________________________________________________________________
CUSIP No. 52728R102 13G Page 5 of 15 Pages
________________________________________________________________________________
1 | NAME OF REPORTING PERSON
| S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
|
| HealthCare Partners IV, L.P.
________|_______________________________________________________________________
2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
| (b) [ ]
________|_______________________________________________________________________
3 | SEC USE ONLY
________|_______________________________________________________________________
4 | CITIZENSHIP OR PLACE OF ORGANIZATION
| Delaware
________|_______________________________________________________________________
| |
| 5 | SOLE VOTING POWER
| |
|_____|__________________________________________________________
NUMBER OF | |
SHARES | 6 | SHARED VOTING POWER
BENEFICIALLY | | 453,982
OWNED BY |_____|__________________________________________________________
EACH | |
REPORTING | 7 | SOLE DISPOSITIVE POWER
PERSON WITH | |
|_____|__________________________________________________________
| |
| 8 | SHARED DISPOSITIVE POWER
| | 453,982
_______________|_____|__________________________________________________________
9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
| 453,982
_______|________________________________________________________________________
10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
| CERTAIN SHARES* [ ]
_______|________________________________________________________________________
11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9
| 5.2%
_______|________________________________________________________________________
12 | TYPE OF REPORTING PERSON*
| PN
_______|________________________________________________________________________
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
________________________________________________________________________________
CUSIP No. 52728R102 13G Page 6 of 15 Pages
________________________________________________________________________________
1 | NAME OF REPORTING PERSON
| S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
|
| James H. Cavanaugh, Ph.D.
________|_______________________________________________________________________
2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
| (b) [ ]
________|_______________________________________________________________________
3 | SEC USE ONLY
________|_______________________________________________________________________
4 | CITIZENSHIP OR PLACE OF ORGANIZATION
| United States
________|_______________________________________________________________________
| |
| 5 | SOLE VOTING POWER
| |
|_____|__________________________________________________________
NUMBER OF | |
SHARES | 6 | SHARED VOTING POWER
BENEFICIALLY | | 1,999,926
OWNED BY |_____|__________________________________________________________
EACH | |
REPORTING | 7 | SOLE DISPOSITIVE POWER
PERSON WITH | |
|_____|__________________________________________________________
| |
| 8 | SHARED DISPOSITIVE POWER
| | 1,999,926
_______________|_____|__________________________________________________________
9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
| 1,999,926
_______|________________________________________________________________________
10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
| CERTAIN SHARES* [ ]
_______|________________________________________________________________________
11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9
| 23.0%
_______|________________________________________________________________________
12 | TYPE OF REPORTING PERSON*
| IN
_______|________________________________________________________________________
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
________________________________________________________________________________
CUSIP No. 52728R102 13G Page 7 of 15 Pages
________________________________________________________________________________
1 | NAME OF REPORTING PERSON
| S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
|
| Harold R. Werner
________|_______________________________________________________________________
2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
| (b) [ ]
________|_______________________________________________________________________
3 | SEC USE ONLY
________|_______________________________________________________________________
4 | CITIZENSHIP OR PLACE OF ORGANIZATION
| United States
________|_______________________________________________________________________
| |
| 5 | SOLE VOTING POWER
| |
|_____|__________________________________________________________
NUMBER OF | |
SHARES | 6 | SHARED VOTING POWER
BENEFICIALLY | | 1,999,926
OWNED BY |_____|__________________________________________________________
EACH | |
REPORTING | 7 | SOLE DISPOSITIVE POWER
PERSON WITH | |
|_____|__________________________________________________________
| |
| 8 | SHARED DISPOSITIVE POWER
| | 1,999,926
_______________|_____|__________________________________________________________
9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
| 1,999,926
_______|________________________________________________________________________
10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
| CERTAIN SHARES* [ ]
_______|________________________________________________________________________
11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9
| 23.0%
_______|________________________________________________________________________
12 | TYPE OF REPORTING PERSON*
| IN
_______|________________________________________________________________________
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
________________________________________________________________________________
CUSIP No. 52728R102 13G Page 8 of 15 Pages
________________________________________________________________________________
1 | NAME OF REPORTING PERSON
| S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
|
| William Crouse
________|_______________________________________________________________________
2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
| (b) [ ]
________|_______________________________________________________________________
3 | SEC USE ONLY
________|_______________________________________________________________________
4 | CITIZENSHIP OR PLACE OF ORGANIZATION
| United States
________|_______________________________________________________________________
| |
| 5 | SOLE VOTING POWER
| |
|_____|__________________________________________________________
NUMBER OF | |
SHARES | 6 | SHARED VOTING POWER
BENEFICIALLY | | 1,999,926
OWNED BY |_____|__________________________________________________________
EACH | |
REPORTING | 7 | SOLE DISPOSITIVE POWER
PERSON WITH | |
|_____|__________________________________________________________
| |
| 8 | SHARED DISPOSITIVE POWER
| | 1,999,926
_______________|_____|__________________________________________________________
9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
| 1,999,926
_______|________________________________________________________________________
10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
| CERTAIN SHARES* [ ]
_______|________________________________________________________________________
11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9
| 23.0%
_______|________________________________________________________________________
12 | TYPE OF REPORTING PERSON*
| IN
_______|________________________________________________________________________
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
________________________________________________________________________________
CUSIP No. 52728R102 13G Page 9 of 15 Pages
________________________________________________________________________________
1 | NAME OF REPORTING PERSON
| S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
|
| John W. Littlechild
________|_______________________________________________________________________
2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
| (b) [ ]
________|_______________________________________________________________________
3 | SEC USE ONLY
________|_______________________________________________________________________
4 | CITIZENSHIP OR PLACE OF ORGANIZATION
| United States
________|_______________________________________________________________________
| |
| 5 | SOLE VOTING POWER
| |
|_____|__________________________________________________________
NUMBER OF | |
SHARES | 6 | SHARED VOTING POWER
BENEFICIALLY | | 1,999,926
OWNED BY |_____|__________________________________________________________
EACH | |
REPORTING | 7 | SOLE DISPOSITIVE POWER
PERSON WITH | |
|_____|__________________________________________________________
| |
| 8 | SHARED DISPOSITIVE POWER
| | 1,999,926
_______________|_____|__________________________________________________________
9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
| 1,999,926
_______|________________________________________________________________________
10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
| CERTAIN SHARES* [ ]
_______|________________________________________________________________________
11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9
| 23.0%
_______|________________________________________________________________________
12 | TYPE OF REPORTING PERSON*
| IN
_______|________________________________________________________________________
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
________________________________________________________________________________
CUSIP No. 52728R102 13G Page 10 of 15 Pages
________________________________________________________________________________
1 | NAME OF REPORTING PERSON
| S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
|
| Mark Leschly
________|_______________________________________________________________________
2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
| (b) [ ]
________|_______________________________________________________________________
3 | SEC USE ONLY
________|_______________________________________________________________________
4 | CITIZENSHIP OR PLACE OF ORGANIZATION
| United States
________|_______________________________________________________________________
| |
| 5 | SOLE VOTING POWER
| |
|_____|__________________________________________________________
NUMBER OF | |
SHARES | 6 | SHARED VOTING POWER
BENEFICIALLY | | 1,999,926
OWNED BY |_____|__________________________________________________________
EACH | |
REPORTING | 7 | SOLE DISPOSITIVE POWER
PERSON WITH | |
|_____|__________________________________________________________
| |
| 8 | SHARED DISPOSITIVE POWER
| | 1,999,926
_______________|_____|__________________________________________________________
9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
| 1,999,926
_______|________________________________________________________________________
10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
| CERTAIN SHARES* [ ]
_______|________________________________________________________________________
11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9
| 23.0%
_______|________________________________________________________________________
12 | TYPE OF REPORTING PERSON*
| IN
_______|________________________________________________________________________
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
________________________________________________________________________________
CUSIP No. 52728R102 13G Page 11 of 15 Pages
________________________________________________________________________________
Item 1.
(a) Name of Issuer:
Leukosite, Inc.
(b) Address of Issuer's Principal Executive Offices:
215 First Street
Cambridge, Massachusetts 02142
Item 2.
(a) Name of Person Filing:
HealthCare Ventures III, L.P. ("HCV III"), HealthCare Partners
III, L.P. ("HCP III"), HealthCare Ventures IV, L.P. ("HCV
IV"), HealthCare Partners IV, L.P. ("HCP IV"), Dr. Cavanaugh
and Messrs. Werner, Littlechild, Crouse and Leschly(1). See
attached Exhibit A which is a copy of their agreement in
writing to file this statement on behalf of each of them.(2)
(b) Address of Principal Business Office or, if none, Residence:
The business address for HCV III, HCP III, HCV IV, HCP IV, Dr.
Cavanaugh and Messrs. Werner and Crouse is 44 Nassau Street,
Princeton, New Jersey 08542. The business address for Messrs.
Littlechild and Leschly is One Kendall Square, Building 300,
Cambridge, Massachusetts 02139.
(c) Citizenship:
HCV III, HCP III, HCV IV and HCP IV are limited partnerships
organized under the laws of the State of Delaware. Dr.
Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly
are each United States citizens.
(d) Title of Class of Securities:
Common Stock, par value $.01 ("Shares").
- --------
(1) Mr. Leschly became a general partner of HCP III and HCP IV effective
January 1, 1998.
(2) Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly are
general partners of each of HCP III and HCP IV, which are the general
partner of each of HCV III and HCV IV, respectively the record holder
of Issuer's securities.
<PAGE>
________________________________________________________________________________
CUSIP No. 52728R102 13G Page 12 of 15 Pages
________________________________________________________________________________
(e) CUSIP Number:
52728R102
Item 3. If this statement is filed pursuant to Rule 13d-1(b), or
13d-2(b), check whether the person filing is a:
Inapplicable.
Item 4. Ownership.
(a) Amount Beneficially Owned:
As of December 31, 1997: HCV III and HCP III beneficially
owned 1,545,944 Shares of Issuer's Securities, consisting of
Shares of Issuer's Common Stock; HCV IV and HCP IV
beneficially owned 453,982 Shares of Issuer's Securities,
consisting of Shares of Issuer's Common Stock; and Dr.
Cavanaugh and Messrs. Werner, Littlechild Crouse and Leschly
beneficially owned 1,999,926 Shares of Issuer's Securities,
consisting of Shares of Issuer's Common Stock.
(b) Percent of Class:
As of December 31, 1997: the 1,545,944 Shares of Issuer's
Securities beneficially owned by HCV III and HCP III
constitute 17.8% of the Issuer's Shares outstanding; the
453,982 Shares of Issuer's Securities beneficially owned by
HCV IV and HCP IV consisted 5.2% of Issuer's Shares
outstanding and the 1,999,926 Shares of Issuer's Securities
beneficially owned by Dr. Cavanaugh and Messrs. Werner,
Littlechild, Crouse and Leschly constitute 23.0% of Issuer's
Shares outstanding.
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote:
Inapplicable
(ii) shared power to vote or to direct the vote:
HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner,
Littlechild, Crouse and Leschly share the power to
vote or direct the vote of those shares owned by HCV
III.
HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner,
Littlechild, Crouse and Leschly share the power to
vote or direct the vote of those shares owned by HCV
IV.
<PAGE>
________________________________________________________________________________
CUSIP No. 52728R102 13G Page 13 of 15 Pages
________________________________________________________________________________
(iii) sole power to dispose or to direct the disposition
of:
Inapplicable
(iv) shared power to dispose of or to direct the
disposition of:
HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner,
Littlechild, Crouse and Leschly share the power to
dispose of or direct the disposition of those shares
owned by HCV III.
HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner,
Littlechild, Crouse and Leschly share the power to
dispose of or direct the disposition of those shares
owned by HCV IV.
Item 5. Ownership of Five Percent or less of a Class:
Inapplicable.
Item 6. Ownership of More than Five Percent on Behalf of Another
Person:
Inapplicable.
Item 7. Identification and Classification of the Subsidiary Which
Acquired the Security Being Reported on by the Parent Holding
Company:
Inapplicable.
Item 8. Identification and Classification of Members of the Group:
Inapplicable.
Item 9. Notice of Dissolution of Group:
Inapplicable.
Item 10. Certification:
Inapplicable.
<PAGE>
________________________________________________________________________________
CUSIP No. 52728R102 13G Page 14 of 15 Pages
________________________________________________________________________________
SIGNATURES
After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.
Dated: February 10, 1998 HealthCare Ventures III, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners III, L.P.
By: /s/ Jeffrey Steinberg
-----------------------------
A General Partner
Dated: February 10, 1998 HealthCare Partners III, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
-----------------------------
A General Partner
Dated: February 10, 1998 HealthCare Ventures IV, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners IV, L.P.
By: /s/ Jeffrey Steinberg
----------------------------
A General Partner
Dated: February 10, 1998 HealthCare Partners IV, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
-----------------------------
A General Partner
Dated: February 10, 1998 By: /s/ Jeffrey Steinberg
Princeton, New Jersey -----------------------------
James H. Cavanaugh, Ph.D.
Dated: February 10, 1998 By: /s/ Jeffrey Steinberg
Princeton, New Jersey -----------------------------
Harold R. Werner
Dated: February 10, 1998 By: /s/ Jeffrey Steinberg
Cambridge, Massachusetts -----------------------------
John W. Littlechild
Dated: February 10, 1998 By: /s/ Jeffrey Steinberg
Princeton, New Jersey -----------------------------
William Crouse
Dated: February 10, 1998 By: /s/ Jeffrey Steinberg
Cambridge, Massachusetts ----------------------------
Mark Leschly
<PAGE>
________________________________________________________________________________
CUSIP No. 584699102 13G Page 15 of 15 Pages
________________________________________________________________________________
EXHIBIT A
AGREEMENT
JOINT FILING OF SCHEDULE 13G
The undersigned hereby agree to jointly prepare and file with
regulatory authorities a Schedule 13G and any future amendments thereto
reporting each of the undersigned's ownership of securities of MedImmune, Inc.
and hereby affirm that such Schedule 13G is being filed on behalf of each of the
undersigned.
Dated: February 10, 1998 HealthCare Ventures III, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners III, L.P.
By: /s/ Jeffrey Steinberg
-------------------------------
A General Partner
Dated: February 10, 1998 HealthCare Partners III, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
-------------------------------
A General Partner
Dated: February 10, 1998 HealthCare Ventures IV, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners IV, L.P.
By: /s/ Jeffrey Steinberg
-------------------------------
A General Partner
Dated: February 10, 1998 HealthCare Partners IV, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
-------------------------------
A General Partner
Dated: February 10, 1998 By: /s/ Jeffrey Steinberg
Princeton, New Jersey -------------------------------
James H. Cavanaugh, Ph.D.
Dated: February 10, 1998 By: /s/ Jeffrey Steinberg
Princeton, New Jersey -------------------------------
Harold R. Werner
Dated: February 10, 1998 By: /s/ Jeffrey Steinberg
Cambridge, Massachusetts -------------------------------
John W. Littlechild
Dated: February 10, 1998 By: /s/ Jeffrey Steinberg
Princeton, New Jersey -------------------------------
William Crouse
Dated: February 10, 1998 By: /s/ Jeffrey Steinberg
Cambridge, Massachusetts -------------------------------
Mark Leschly
