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                                               Filed Pursuant To Rule 424(b)(3)
                                                      Registration No. 333-2140 


PROSPECTUS SUPPLEMENT NO. 1
TO THE PROSPECTUS DATED JUNE 10, 1996
 


                      [LOGO]  COLLABORATIVE           
                              CLINICAL RESEARCH, INC. 


     This Prospectus Supplement is part of the Prospectus dated June 10, 1996
and should be read in conjunction therewith.
 
     On June 28, 1996, Collaborative Clinical Research, Inc. and Integrated
Systems Solutions Corporation, a wholly-owned subsidiary of IBM Corporation, 
signed an exclusive ten-year technology alliance agreement to develop and 
market an electronic data collection and project management system for use in 
clinical trials.
 
           The date of this Prospectus Supplement is July 2, 1996.
 
                                                      
                                                      



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