COLLABORATIVE CLINICAL RESEARCH INC
8-A12G, 1996-05-10
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>   1

                       SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549


                                    FORM 8-A


                     For Registration of Certain Classes of
                Securities Pursuant to Section 12(b) or 12(g) of
                      The Securities Exchange Act of 1934


                     Collaborative Clinical Research, Inc.
             (Exact name of registrant as specified in its charter)


          Ohio                                34-1685364           
- ------------------------          ---------------------------------
(State of incorporation           (IRS Employer Identification No.)
    or organization)


20600 Chagrin Boulevard, Suite 1050, Cleveland, Ohio     44122 
- ------------------------------------------------------   -------
      (Address of principal executive offices)         (Zip Code)


<TABLE>
<S>                                                <C>
If this Form relates to the registration           If this Form relates to the registration of a
of a class of debt securities and is               class of debt securities and is to become
effective upon filing pursuant to General          effective simultaneously with the effectiveness of
Instruction A(c)(1) please check the               a concurrent registration statement under the
following box.  [ ]                                Securities Act of 1933 pursuant to General
                                                   Instruction A(c)(2) please check the following
                                                   box.  [ ]                                     
                                                                                                 
                                                          
</TABLE>

Securities to be registered pursuant to Section 12(b) of the Act:

                                Not Applicable

<TABLE>
<S>                                                <C>
Title of each class to be                          Name of each exchange on
      so registered                                which each class is to
                                                       to be registered
                                                   
      Not Applicable                                    Not Applicable    
  ----------------------                            ----------------------
                                                                          
  ----------------------                            ----------------------
                                                                          
  ----------------------                            ----------------------
</TABLE>

Securities to be registered pursuant to Section 12(g) of the Act:

                        Common Shares, without par value
                        --------------------------------
                                (Title of Class)
<PAGE>   2
Item 1.  Description of Registrant's Securities to be Registered
- -------  -------------------------------------------------------

                 The description of the Registrant's Common Shares, without par
                 value, set forth under the caption "Description of Capital
                 Stock" in the Registrant's Registration Statement on Form S-1,
                 filed with the Securities and Exchange Commission (the
                 "Commission") on March 8, 1996, File Number 333-2140,
                 including exhibits, as amended by any amendments filed with
                 the Commission prior or subsequent to the effectiveness of the
                 Registrant's Registration Statement on Form S-1 (the "Form S-1
                 Registration Statement"), is hereby incorporated by reference.


Item 2.  Exhibits
- -------  --------

<TABLE>
<CAPTION>
    Number                                   Description
    -------                                  -----------
       <S>               <C>
       1.                Specimen certificate for the Common Shares,
                         without par value, of the Registrant (incorporated
                         herein by reference to Exhibit 4.1 to the Form S-1
                         Registration Statement).
    
       2.                Fourth Amended and Restated Articles of
                         Incorporation of the Registrant (incorporated
                         herein by reference to Exhibit 3.1 to the Form S-1
                         Registration Statement).
    
       3.                Form of Fifth Amended and Restated Articles of
                         Incorporation of the Registrant (incorporated
                         herein by reference to Exhibit 3.2 to the Form S-1
                         Registration Statement).
    
       4.                Second Amended and Restated Code of Regulations of
                         the Registrant (incorporated herein by reference
                         to Exhibit 3.3 to the Form S-1 Registration
                         Statement).
</TABLE>





                                      -2-
<PAGE>   3

<TABLE>
<CAPTION>
    Number                                   Description
    -------                                  -----------
      <S>                <C>
       5.                Form of Third Amended and Restated Code of
                         Regulations of the Registrant (incorporated herein
                         by reference to Exhibit 3.4 to the Form S-1
                         Registration Statement).
    
       6.                Warrant Agreement, dated June 1, 1995, by and
                         between the Registrant and PMSI (incorporated
                         herein by reference to Exhibit 4.2 to the Form S-1
                         Registration Statement).
    
       7.                Demand Promissory Note, dated as of January 19,
                         1995, payable to the order of Society National
                         Bank (incorporated herein by reference to Exhibit
                         4.3 to the Form S-1 Registration Statement).
    
       8.                Promissory Note, dated February 1, 1996, payable
                         to the order of Debra S. Adamson (incorporated
                         herein by reference to Exhibit 4.4 to the Form S-1
                         Registration Statement).
    
       9.                Promissory Note, dated February 1, 1996, payable
                         to the order of Mary L. Westrick (incorporated
                         herein by reference to Exhibit 4.5 to the Form S-1
                         Registration Statement).
    
      10.                Stock Purchase Agreement, dated as of March 25,
                         1992, by and between the Company and Brantley
                         Venture Partners II, L.P. (incorporated herein by
                         reference to Exhibit 4.6 to the Form S-1
                         Registration Statement).
</TABLE>





                                      -3-
<PAGE>   4

<TABLE>
<CAPTION>
    Number                                   Description
    -------                                  -----------
      <S>                <C>
      11.                Stock Purchase Agreement, dated as of November 25,
                         1992, by and among the Company, James A. Terwoord
                         and Seth Harris (incorporated herein by reference
                         to Exhibit 4.7 to the Form S-1 Registration
                         Statement).
    
      12.                Share Purchase Agreement, dated as of July 24,
                         1994, by and among the Company, Oxford BioScience
                         Partners, L.P., Oxford BioScience Partners
                         (Bermuda) Limited Partnership, Oxford BioScience
                         Partners (Adjunct) L.P., Axiom Venture Partners
                         Limited Partnership, Brantley Venture Partners II,
                         L.P., Dr. Barry M. Bloom, Dr. Richard J. Kasmer,
                         Dr. William H. Stigelman, Jr., Seth Harris, Dr.
                         Robert M. Stote, Dr. Jeffrey A. Green and Delaware
                         Charter Guarantee & Trust Company, Trustee FBO
                         James A. Terwoord IRA No. 450-39040-1-5
                         (incorporated herein by reference to Exhibit 4.8
                         to the Form S-1 Registration Statement).
    
      13.                Second Amended and Restated Shareholders'
                         Agreement, dated as of July 15, 1994, as amended
                         on June 1, 1995 and February 5, 1996 (incorporated
                         herein by reference to Exhibit 4.9 to the Form S-1
                         Registration Statement).
    
      14.                Second Amended and Restated Registration
                         Agreement, dated as of July 15, 1994, as amended
                         on June 1, 1995 and February 5, 1996 (incorporated
                         herein by reference to Exhibit 4.10 to the Form S-1
                         Registration Statement).
</TABLE>





                                      -4-
<PAGE>   5
                                   SIGNATURE


                 Pursuant to the requirements of Section 12 of the Securities
Exchange Act of 1934, the registrant has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereto duly
authorized.


                                           COLLABORATIVE CLINICAL RESEARCH, INC.
                                                                    (Registrant)


                                           By  /s/Terry C. Black
                                               ---------------------------------
                                                Terry C. Black
                                                Chief Financial Officer,
                                                Vice President of Finance,
                                                Treasurer and Assistant
                                                Secretary

Date: May 10, 1996






                                      -5-
<PAGE>   6
                                 EXHIBIT INDEX
                                 -------------

<TABLE>
<CAPTION>
    Exhibit                                    Exhibit
    Number                                   Description
    -------                                  -----------
       <S>               <C>
       1.                Specimen certificate for the Common Shares,
                         without par value, of the Registrant (incorporated
                         herein by reference to Exhibit 4.1 to the Form S-1
                         Registration Statement).
    
       2.                Fourth Amended and Restated Articles of
                         Incorporation of the Registrant (incorporated
                         herein by reference to Exhibit 3.1 to the Form S-1
                         Registration Statement).
    
       3.                Form of Fifth Amended and Restated Articles of
                         Incorporation of the Registrant (incorporated
                         herein by reference to Exhibit 3.2 to the Form S-1
                         Registration Statement).
    
       4.                Second Amended and Restated Code of Regulations of
                         the Registrant (incorporated herein by reference
                         to Exhibit 3.3 to the Form S-1 Registration
                         Statement).
    
       5.                Form of Fourth Amended and Restated Code of
                         Regulations of the Registrant (incorporated herein
                         by reference to Exhibit 3.4 to the Form S-1
                         Registration Statement).
</TABLE>





                                      -6-
<PAGE>   7
<TABLE>
<CAPTION>
  Exhibit                                    Exhibit
  Number                                   Description
  ------                                   -----------
    <S>                <C>
     6.                Warrant Agreement, dated June 1, 1995, by and
                       between the Registrant and PMSI (incorporated
                       herein by reference to Exhibit 4.2 to the Form S-1
                       Registration Statement).

     7.                Demand Promissory Note, dated as of January 19,
                       1995, payable to the order of Society National
                       Bank (incorporated herein by reference to Exhibit
                       4.3 to the Form S-1 Registration Statement).
    
     8.                Promissory Note, dated February 1, 1996, payable
                       to the order of Debra S. Adamson (incorporated
                       herein by reference to Exhibit 4.4 to the Form S-1
                       Registration Statement).
    
     9.                Promissory Note, dated February 1, 1996, payable
                       to the order of Mary L. Westrick (incorporated
                       herein by reference to Exhibit 4.5 to the Form S-1
                       Registration Statement).
    
    10.                Stock Purchase Agreement, dated as of March 25,
                       1992, by and between the Company and Brantley
                       Venture Partners II, L.P. (incorporated herein by
                       reference to Exhibit 4.6 to the Form S-1
                       Registration Statement).
    
    11.                Stock Purchase Agreement, dated as of November 25,
                       1992, by and among the Company, James A. Terwoord
                       and Seth Harris (incorporated herein by reference
                       to Exhibit 4.7 to the Form S-1 Registration
                       Statement).
</TABLE>





                                      -7-
<PAGE>   8
<TABLE>
<CAPTION>
  Exhibit                                    Exhibit
  Number                                   Description
  ------                                   -----------
    <S>                <C>
    12.                Share Purchase Agreement, dated as of July 24,
                       1994, by and among the Company, Oxford BioScience
                       Partners, L.P., Oxford BioScience Partners
                       (Bermuda) Limited Partnership, Oxford BioScience
                       Partners (Adjunct) L.P., Axiom Venture Partners
                       Limited Partnership, Brantley Venture Partners II,
                       L.P., Dr. Barry M. Bloom, Dr. Richard J. Kasmer,
                       Dr. William H. Stigelman, Jr., Seth Harris, Dr.
                       Robert M. Stote, Dr. Jeffrey A. Green and Delaware
                       Charter Guarantee & Trust Company, Trustee FBO
                       James A. Terwoord IRA No. 450-39040-1-5
                       (incorporated herein by reference to Exhibit 4.8
                       to the Form S-1 Registration Statement).
    
    13.                Second Amended and Restated Shareholders'
                       Agreement, dated as of July 15, 1994, as amended
                       on June 1, 1995 and February 5, 1996 (incorporated
                       herein by reference to Exhibit 4.9 to the Form S-1
                       Registration Statement).
    
    14.                Second Amended and Restated Registration
                       Agreement, dated as of July 15, 1994, as amended
                       on June 1, 1995 and February 5, 1996 (incorporated
                       herein by reference to Exhibit 4.10 to the Form S-1
                       Registration Statement).
</TABLE>





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