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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
Under the Securities Exchange Act of 1934
(Amendment No. 2 )*
Collaborative Clinical Research, Inc.
-------------------------------------
(Name of Issuer)
Common Stock, $.01 par value
----------------------------
(Title of Class of Securities)
194190 10 4
--------------
(CUSIP Number)
*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
<PAGE>
- ------------------------- ---------------------------
|CUSIP NO. 444903108 | 13G | Page 2 of 16 Pages |
| --------- | | --- -- |
- ------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAME OF REPORTING PERSON |
| | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | Oxford Bioscience Partners L.P. |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] |
| | (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Delaware Limited Partnership |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | 0 Shares |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 607,752 Shares |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | 0 Shares |
| PERSON |--------|---------------------------------------------------|
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | 607,752 Shares |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 607,752 Shares |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES* |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| | 9.5% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON* |
| | PN |
- --------------------------------------------------------------------------------
Page 2 of 16 Pages
<PAGE>
- ------------------------- ---------------------------
|CUSIP NO. 444903108 | 13G | Page 3 of 16 Pages |
| --------- | | --- -- |
- ------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAME OF REPORTING PERSON |
| | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | Oxford Bioscience Partners (Adjunct) L.P. |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] |
| | (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Delaware Limited Partnership |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | 0 Shares |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 607,752 Shares |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | 0 Shares |
| PERSON |--------|---------------------------------------------------|
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | 607,752 Shares |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 607,752 Shares |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES* |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| | 9.5% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON* |
| | PN |
- --------------------------------------------------------------------------------
Page 3 of 16 Pages
<PAGE>
- ------------------------- ---------------------------
|CUSIP NO. 444903108 | 13G | Page 4 of 16 Pages |
| --------- | | --- -- |
- ------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAME OF REPORTING PERSON |
| | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | OBP Management L.P. |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] |
| | (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Delaware Limited Partnership |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | 0 Shares |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 607,752 Shares |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | 0 Shares |
| PERSON |--------|---------------------------------------------------|
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | 607,752 Shares |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 607,752 Shares |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES* |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| | 9.5% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON* |
| | PN |
- --------------------------------------------------------------------------------
Page 4 of 16 Pages
<PAGE>
- ------------------------- ---------------------------
|CUSIP NO. 444903108 | 13G | Page 5 of 16 Pages |
| --------- | | --- -- |
- ------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAME OF REPORTING PERSON |
| | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | Oxford Bioscience Partners (Bermuda) Limited Partnership |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] |
| | (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Bermuda Limited Partnership |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | 0 Shares |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 607,752 Shares |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | 0 Shares |
| PERSON |--------|---------------------------------------------------|
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | 607,752 Shares |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 607,752 Shares |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES* |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| | 9.5% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON* |
| | PN |
- --------------------------------------------------------------------------------
Page 5 of 16 Pages
<PAGE>
- ------------------------- ---------------------------
|CUSIP NO. 444903108 | 13G | Page 6 of 16 Pages |
| --------- | | --- -- |
- ------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAME OF REPORTING PERSON |
| | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | OBP Management (Bermuda) Limited Partnership |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] |
| | (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Bermuda Limited Partnership |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | 0 Shares |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 607,752 Shares |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | 0 Shares |
| PERSON |--------|---------------------------------------------------|
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | 607,752 Shares |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 607,752 Shares |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES* |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| | 9.5% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON* |
| | PN |
- --------------------------------------------------------------------------------
Page 6 of 16 Pages
<PAGE>
- ------------------------- ---------------------------
|CUSIP NO. 444903108 | 13G | Page 7 of 16 Pages |
| --------- | | --- -- |
- ------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAME OF REPORTING PERSON |
| | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | Edmund M. Olivier |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] |
| | (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | United States |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | 0 Shares |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 607,752 Shares |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | 0 Shares |
| PERSON |--------|---------------------------------------------------|
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | 607,752 Shares |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 607,752 Shares |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES* |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| | 9.5% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON* |
| | IN |
- --------------------------------------------------------------------------------
Page 7 of 16 Pages
<PAGE>
- ------------------------- ---------------------------
|CUSIP NO. 444903108 | 13G | Page 8 of 16 Pages |
| --------- | | --- -- |
- ------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAME OF REPORTING PERSON |
| | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | Cornelius T. Ryan |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] |
| | (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | United States |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | 0 Shares |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 607,752 Shares |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | 0 Shares |
| PERSON |--------|---------------------------------------------------|
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | 607,752 Shares |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 607,752 Shares |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES* |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| | 9.5% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON* |
| | IN |
- --------------------------------------------------------------------------------
Page 8 of 16 Pages
<PAGE>
- ------------------------- ---------------------------
|CUSIP NO. 444903108 | 13G | Page 9 of 16 Pages |
| --------- | | --- -- |
- ------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAME OF REPORTING PERSON |
| | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | Alan G. Walton |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] |
| | (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | United States |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | 0 Shares |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 607,752 Shares |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | 0 Shares |
| PERSON |--------|---------------------------------------------------|
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | 607,752 Shares |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 607,752 Shares |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES* |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| | 9.5% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON* |
| | IN |
- --------------------------------------------------------------------------------
Page 9 of 16 Pages
<PAGE>
NOTE: This Statement on Schedule 13G is being filed
on behalf of (i) Oxford Bioscience Partners L.P., a Delaware limited
partnership; (ii) Oxford Bioscience Partners (Adjunct) L.P., a Delaware limited
partnership; (iii) OBP Management L.P., a Delaware limited partnership; (iv)
Oxford Bioscience Partners (Bermuda) Limited Partnership, a Bermuda limited
partnership; (v) OBP Management (Bermuda) Limited Partnership, a Bermuda limited
partnership; (vi) Edmund M. Olivier; (vii) Cornelius T. Ryan; and (viii) Alan G.
Walton.
Item 1(a). Name of Issuer: Collaborative Clinical Research, Inc.
--------------
Item 1(b). Address of Issuer's Principal Executive Offices:
-----------------------------------------------
20600 Chagrin Blvd., Cleveland, Ohio 44122
<TABLE>
<CAPTION>
Item 2(a) Item 2(b) Item 2(c)
Citizenship or Place
Name of Person Filing Address of Organization
<S> <C> <C>
Oxford Bioscience Partners L.P. Oxford Bioscience Partners Delaware
("OBP") 315 Post Road West
Westport, CT 06880
Oxford Bioscience Partners Oxford Bioscience Partners Delaware
(Adjunct) L.P. ("OBP Adjunct") 315 Post Road West
Westport, CT 06880
OBP Management L.P. ("OBP Oxford Bioscience Partners Delaware
Management"), the general 315 Post Road West
partner of OBP and OBP Adjunct Westport, CT 06880
Oxford Bioscience Partners Richmond House Bermuda
(Bermuda) Limited Partnership Par-la-Ville Road
("OBP Bermuda') Hamilton, Bermuda
OBP Management (Bermuda) Limited Richmond House Bermuda
Partnership ("OBP Management Par-la-Ville Road
Bermuda"), the general Hamilton, Bermuda
partner of OBP Bermuda
Edmund M. Olivier, a general Oxford Bioscience Partners United States
partner of OBP Management and 650 Town Center Drive
OBP Management Bermuda Costa Mesa, California 92626
Cornelius T. Ryan, a general Oxford Bioscience Partners United States
partner of OBP Management and 315 Post Road West
OBP Management Bermuda Westport, CT 06880
Alan G. Walton, a general partner Oxford Bioscience Partners United States
of OBP Management and OBP 315 Post Road West
Management Bermuda Westport, CT 06880
</TABLE>
Item 2(d). Title of Class of Securities: Common Stock, $.01 par value.
----------------------------
Page 10 of 16 pages
<PAGE>
Item 2(e). CUSIP Number: 194190 10 4
------------
Item 3. If this statement is filed pursuant to Rules 13d-1(b), or
---------------------------------------------------------
13d-2(b), check whether the person filing is a:
----------------------------------------------
(a) [ ] Broker or Dealer registered under Section 15 of
the Securities Exchange Act of 1934 (the "Act").
(b) [ ] Bank as defined in Section 3(a)(6) of the Act.
(c) [ ] Insurance Company as defined in Section 3(a)(19)
of the Act.
(d) [ ] Investment Company registered under Section 8 of
the Investment Company Act of 1940.
(e) [ ] Investment Adviser registered under Section 203
of the Investment Advisers Act of 1940.
(f) [ ] Employee Benefit Plan, Pension Fund which is
subject to the provisions of the Employee
Retirement Income Security Act of 1974 or
Endowment Fund; see Rule 13d-1(b)(1)(ii)(F) of
the Act.
(g) [ ] Parent Holding Company, in accordance with Rule
13d-1(b)(ii)(G) of the Act.
(h) [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(H)
of the Act.
None of the above.
Item 4. Ownership.
----------
(a) Amount Beneficially Owned: As of December 31, 1997, each
of the following is the owner of record of the number of
shares of Common Stock set forth next to his, her or its
name:
OBP: 408,690 Shares
OBP Adjunct: 82,517 Shares
OBP Management: 0 Shares
OBP Bermuda: 113,378 Shares
OBP Management Bermuda: 0 Shares
Mr. Olivier: 0 Shares
Mr. Ryan: 0 Shares
Mr. Walton: 0 Shares
By virtue of their relationship as affiliated limited
partnerships, whose sole general partners share individual
general partners, OBP, OBP Adjunct and OBP Bermuda may be deemed
to share voting power and the power to direct the disposition of
the shares of Common Stock which each partnership owns of
record. Additionally, OBP Management owns presently exerciseable
options to purchase an aggregate of 3,167 shares of Common
Stock. Messrs. Ryan, Walton and Olivier are general partners of
both OBP Management, the general partner of OBP and OBP Adjunct,
and OBP Bermuda Management, the general partner OBP Bermuda.
Therefore, each of Messrs. Ryan, Walton and Olivier may be
deemed to own beneficially the shares and options held by OBP,
OBP Adjunct and OBP Bermuda.
Page 11 of 16 pages
<PAGE>
(b) Percent of Class:
OBP: 9.5%
OBP Adjunct: 9.5%
OBP Management: 9.5%
OBP Bermuda: 9.5%
OBP Management Bermuda: 9.5%
Mr. Olivier: 9.5%
Mr. Ryan: 9.5%
Mr. Walton: 9.5%
The foregoing percentages are calculated based on the 6,407,247
shares of Common Stock reported to be outstanding as of October
31, 1997 in the Quarterly Report on Form 10-Q of Collaborative
Clinical Research, Inc. for the quarter ended September 30,
1997, as adjusted pursuant to Rule 13d-3 (d)(1) of the Act.
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote:
OBP: 0 Shares
OBP Adjunct: 0 Shares
OBP Management: 0 Shares
OBP Bermuda: 0 Shares
OBP Management Bermuda: 0 Shares
Mr. Olivier: 0 Shares
Mr. Ryan: 0 Shares
Mr. Walton: 0 Shares
(ii) shared power to vote or to direct the vote:
OBP: 607,752 Shares
OBP Adjunct: 607,752 Shares
OBP Management: 607,752 Shares
OBP Bermuda: 607,752 Shares
OBP Management Bermuda: 607,752 Shares
Mr. Olivier: 607,752 Shares
Mr. Ryan: 607,752 Shares
Mr. Walton: 607,752 Shares
Page 12 of 16 pages
<PAGE>
(iii) sole power to dispose or to direct the disposition of:
OBP: 0 Shares
OBP Adjunct: 0 Shares
OBP Management: 0 Shares
OBP Bermuda: 0 Shares
OBP Management Bermuda: 0 Shares
Mr. Olivier: 0 Shares
Mr. Ryan: 0 Shares
Mr. Walton: 0 Shares
(iv) shared power to dispose or to direct the disposition of:
OBP: 607,752 Shares
OBP Adjunct: 607,752 Shares
OBP Management: 607,752 Shares
OBP Bermuda: 607,752 Shares
OBP Management Bermuda: 607,752 Shares
Mr. Olivier: 607,752 Shares
Mr. Ryan: 607,752 Shares
Mr. Walton: 607,752 Shares
Each of OBP, OBP Adjunct, OBP Management, OBP Bermuda, OBP
Management Bermuda, Mr. Olivier, Mr. Ryan and Mr. Walton
expressly disclaims beneficial ownership of any shares of Common
Stock of Collaborative Clinical Research, Inc., except any
shares held directly of record.
Item 5. Ownership of Five Percent or Less of a Class.
---------------------------------------------
If this statement is being filed to report the fact that as of
the date hereof the reporting person has ceased to be the
beneficial owner of more than five percent of the class of
securities, check the following: [ ]
Item 6. Ownership of More than Five Percent on Behalf of Another Person.
----------------------------------------------------------------
Not applicable.
Item 7. Identification and Classification of the Subsidiary Which
Acquired the Security Being Reported on by the Parent Holding
Company.
-------------------------------------------------------------
Not applicable.
Item 8. Identification and Classification of Members of the Group.
----------------------------------------------------------
Not applicable. OBP, OBP Adjunct, OBP Management, OBP Bermuda,
OBP Management Bermuda, Mr. Olivier, Mr. Ryan and Mr. Walton
expressly disclaim membership in a "group" as defined in
Rule 13d-1(b)(ii)(H) of the Act.
Item 9. Notice of Dissolution of Group.
-------------------------------
Not applicable.
Page 13 of 16 pages
<PAGE>
Item 10. Certification.
--------------
Not applicable. This statement on Schedule 13G is not filed
pursuant to Rule 13d-1(b).
Page 14 of 16 pages
<PAGE>
Signature
After reasonable inquiry and to the best of his, her or its knowledge
and belief, each of the undersigned certifies that the information set forth in
this statement is true, complete and correct. We also hereby agree to file this
statement jointly pursuant to the agreement set forth as Exhibit 1 to our
intitial Schedule 13G filing.
Dated: February 13, 1998
OXFORD BIOSCIENCE PARTNERS L.P.
By: OBP Management L.P., its general partner
By: /s/ Alan G. Walton
---------------------------------
Alan G. Walton
General Partner
OXFORD BIOSCIENCE PARTNERS
(ADJUNCT) L.P.
By: OBP Management L.P., its general partner
By: /s/ Alan G. Walton
---------------------------------
Alan G. Walton
General Partner
OXFORD BIOSCIENCE PARTNERS
(BERMUDA) LIMITED PARTNERSHIP
By: OBP Management (Bermuda) Limited
Partnership, its general partner
By: /s/ Alan G. Walton
---------------------------------
Alan G. Walton
General Partner
OBP MANAGEMENT L.P.
By: /s/ Alan G. Walton
---------------------------------
Alan G. Walton
General Partner
OBP MANAGEMENT (BERMUDA) LIMITED
PARTNERSHIP
By: /s/ Alan G. Walton
---------------------------------
Alan G. Walton
General Partner
Page 15 of 16 pages
<PAGE>
/s/ Cornelius T. Ryan
---------------------------------
Cornelius T. Ryan
/s/ Alan G. Walton
---------------------------------
Alan G. Walton
/s/ Edmund M. Olivier
---------------------------------
Edmund M. Olivier
Page 16 of 16 pages
