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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
Under the Securities Exchange Act of 1934
(Amendment No. 3 )*
Collaborative Clinical Research, Inc.
- --------------------------------------------------------------------------------
(Name of Issuer)
Common Stock, no par value
- --------------------------------------------------------------------------------
(Title of Class of Securities)
194190 10 4
-----------------------------------------------
(CUSIP Number)
December 31, 1998
- --------------------------------------------------------------------------------
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:
[ ] Rule 13d-1(b)
[ ] Rule 13d-1(c)
[X] Rule 13d-1(d)
*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
Page 1 of 19 pages
<PAGE>
- ---------------------------------- ---------------------------
|CUSIP NO. 194190 10 4 | 13G | Page 2 of 19 Pages |
| ------------ | | --- --- |
- ---------------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAMES OF REPORTING PERSONS |
| | I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) |
| | |
| | Oxford Bioscience Partners, L.P. |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) [ ] |
| | (SEE INSTRUCTIONS) (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Delaware Limited Partnership |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | 0 Shares |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 604,585 Shares |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | 0 Shares |
| PERSON |--------|---------------------------------------------------|
| WITH: | 8 | SHARED DISPOSITIVE POWER |
| | | 604,585 Shares |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 604,585 Shares |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES (SEE INSTRUCTIONS) |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | 9.4% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) |
| | PN |
- --------------------------------------------------------------------------------
Page 2 of 19 pages
<PAGE>
- ---------------------------------- ---------------------------
|CUSIP NO. 194190 10 4 | 13G | Page 3 of 19 Pages |
| ------------ | | --- --- |
- ---------------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAMES OF REPORTING PERSONS |
| | I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) |
| | |
| | Oxford Bioscience Partners (Adjunct) L.P. |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) [ ] |
| | (SEE INSTRUCTIONS) (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Delaware Limited Partnership |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | 0 Shares |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 604,585 Shares |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | 0 Shares |
| PERSON |--------|---------------------------------------------------|
| WITH: | 8 | SHARED DISPOSITIVE POWER |
| | | 604,585 Shares |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 604,585 Shares |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES (SEE INSTRUCTIONS) |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | 9.4% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) |
| | PN |
- --------------------------------------------------------------------------------
Page 3 of 19 pages
<PAGE>
- ---------------------------------- ---------------------------
|CUSIP NO. 194190 10 4 | 13G | Page 4 of 19 Pages |
| ------------ | | --- --- |
- ---------------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAMES OF REPORTING PERSONS |
| | I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) |
| | |
| | OBP Management L.P. |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) [ ] |
| | (SEE INSTRUCTIONS) (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Delaware Limited Partnership |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | 0 Shares |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 604,585 Shares |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | 0 Shares |
| PERSON |--------|---------------------------------------------------|
| WITH: | 8 | SHARED DISPOSITIVE POWER |
| | | 604,585 Shares |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 604,585 Shares |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES (SEE INSTRUCTIONS) |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | 9.4% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) |
| | PN |
- --------------------------------------------------------------------------------
Page 4 of 19 pages
<PAGE>
- ---------------------------------- ---------------------------
|CUSIP NO. 194190 10 4 | 13G | Page 5 of 19 Pages |
| ------------ | | --- --- |
- ---------------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAMES OF REPORTING PERSONS |
| | I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) |
| | |
| | Oxford Bioscience Partners (Bermuda) Limited Partnership |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) [ ] |
| | (SEE INSTRUCTIONS) (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Bermuda Limited Partnership |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | 0 Shares |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 604,585 Shares |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | 0 Shares |
| PERSON |--------|---------------------------------------------------|
| WITH: | 8 | SHARED DISPOSITIVE POWER |
| | | 604,585 Shares |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 604,585 Shares |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES (SEE INSTRUCTIONS) |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | 9.4% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) |
| | PN |
- --------------------------------------------------------------------------------
Page 5 of 19 pages
<PAGE>
- ---------------------------------- ---------------------------
|CUSIP NO. 194190 10 4 | 13G | Page 6 of 19 Pages |
| ------------ | | --- --- |
- ---------------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAMES OF REPORTING PERSONS |
| | I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) |
| | |
| | OBP Management (Bermuda) Limited Partnership |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) [ ] |
| | (SEE INSTRUCTIONS) (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Bermuda Limited Partnership |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | 0 Shares |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 604,585 Shares |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | 0 Shares |
| PERSON |--------|---------------------------------------------------|
| WITH: | 8 | SHARED DISPOSITIVE POWER |
| | | 604,585 Shares |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 604,585 Shares |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES (SEE INSTRUCTIONS) |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | 9.4% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) |
| | PN |
- --------------------------------------------------------------------------------
Page 6 of 19 pages
<PAGE>
- ---------------------------------- ---------------------------
|CUSIP NO. 194190 10 4 | 13G | Page 7 of 19 Pages |
| ------------ | | --- --- |
- ---------------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAMES OF REPORTING PERSONS |
| | I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) |
| | |
| | Edmund M. Olivier |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) [ ] |
| | (SEE INSTRUCTIONS) (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | United States |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | 0 Shares |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 604,585 Shares |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | 0 Shares |
| PERSON |--------|---------------------------------------------------|
| WITH: | 8 | SHARED DISPOSITIVE POWER |
| | | 604,585 Shares |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 604,585 Shares |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES (SEE INSTRUCTIONS) |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | 9.4% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) |
| | IN |
- --------------------------------------------------------------------------------
Page 7 of 19 pages
<PAGE>
- ---------------------------------- ---------------------------
|CUSIP NO. 194190 10 4 | 13G | Page 8 of 19 Pages |
| ------------ | | --- --- |
- ---------------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAMES OF REPORTING PERSONS |
| | I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) |
| | |
| | Cornelius T. Ryan |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) [ ] |
| | (SEE INSTRUCTIONS) (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | United States |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | 0 Shares |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 604,585 Shares |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | 0 Shares |
| PERSON |--------|---------------------------------------------------|
| WITH: | 8 | SHARED DISPOSITIVE POWER |
| | | 604,585 Shares |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 604,585 Shares |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES (SEE INSTRUCTIONS) |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | 9.4% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) |
| | IN |
- --------------------------------------------------------------------------------
Page 8 of 19 pages
<PAGE>
- ---------------------------------- ---------------------------
|CUSIP NO. 194190 10 4 | 13G | Page 9 of 19 Pages |
| ------------ | | --- --- |
- ---------------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAMES OF REPORTING PERSONS |
| | I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) |
| | |
| | Alan G. Walton |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) [ ] |
| | (SEE INSTRUCTIONS) (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | United States |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | 0 Shares |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 604,585 Shares |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | 0 Shares |
| PERSON |--------|---------------------------------------------------|
| WITH: | 8 | SHARED DISPOSITIVE POWER |
| | | 604,585 Shares |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 604,585 Shares |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES (SEE INSTRUCTIONS) |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | 9.4% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) |
| | IN |
- --------------------------------------------------------------------------------
Page 9 of 19 pages
<PAGE>
- ---------------------------------- ---------------------------
|CUSIP NO. 194190 10 4 | 13G | Page 10 of 19 Pages |
| ------------ | | --- --- |
- ---------------------------------- ---------------------------
NOTE: This Statement on Schedule 13G is being filed on behalf of (i) Oxford
Bioscience Partners L.P., a Delaware limited partnership; (ii) Oxford Bioscience
Partners (Adjunct) L.P., a Delaware limited partnership; (iii) OBP Management
L.P., a Delaware limited partnership; (iv) Oxford Bioscience Partners (Bermuda)
Limited Partnership, a Bermuda limited partnership; (v) OBP Management (Bermuda)
Limited Partnership, a Bermuda limited partnership; (vi) Edmund M. Olivier;
(vii) Cornelius T. Ryan; and (viii) Alan G. Walton.
Item 1(a). Name of Issuer: Collaborative Clinical Research, Inc.
--------------
Item 1(b). Address of Issuer's Principal Executive Offices:
------------------------------------------------
20600 Chagrin Blvd., Cleveland, Ohio 44122
<TABLE>
<CAPTION>
Item 2(a) Item 2(b) Item 2(c)
--------- --------- ---------
Citizenship or Place
Name of Person Filing Address of Organization
--------------------- ------- ---------------
<S> <C> <C>
Oxford Bioscience Partners L.P. Oxford Bioscience Partners Delaware
("OBP") 315 Post Road West
Westport, CT 06880
Oxford Bioscience Partners Oxford Bioscience Partners Delaware
(Adjunct) L.P. ("OBP Adjunct") 315 Post Road West
Westport, CT 06880
OBP Management L.P. ("OBP Oxford Bioscience Partners Delaware
Management"), the general 315 Post Road West
partner of OBP and OBP Adjunct Westport, CT 06880
Oxford Bioscience Partners Richmond House Bermuda
(Bermuda) Limited Partnership Par-la-Ville Road
("OBP Bermuda") Hamilton, Bermuda
OBP Management (Bermuda) Limited Richmond House Bermuda
Partnership ("OBP Management Par-la-Ville Road
Bermuda"), the general partner Hamilton, Bermuda
of OBP Bermuda
Edmund M. Olivier, a general Oxford Bioscience Partners United States
partner of OBP Management and 650 Town Center Drive
OBP Management Bermuda Costa Mesa, California 92626
Cornelius T. Ryan, a general Oxford Bioscience Partners United States
partner of OBP Management and 315 Post Road West
OBP Management Bermuda Westport, CT 06880
Alan G. Walton, a general partner Oxford Bioscience Partners United States
of OBP Management and OBP 315 Post Road West
Management Bermuda Westport, CT 06880
</TABLE>
Item 2(d). Title of Class of Securities: Common Stock, no par value.
- ---------- -----------------------------
Item 2(e). CUSIP Number: 194190 10 4
------------
Item 3. If this statement is filed pursuant to Rules 13d-1(b), or
---------------------------------------------------------
13d-2(b), check whether the person filing is a:
-----------------------------------------------
Page 10 of 19 pages
<PAGE>
- ---------------------------------- ---------------------------
|CUSIP NO. 194190 10 4 | 13G | Page 11 of 19 Pages |
| ------------ | | --- --- |
- ---------------------------------- ---------------------------
(a) [ ] Broker or Dealer registered under Section 15 of the
Securities Exchange Act of 1934 (the "Act").
(b) [ ] Bank as defined in Section 3(a)(6) of the Act.
(c) [ ] Insurance Company as defined in Section 3(a)(19) of
the Act.
(d) [ ] Investment Company registered under Section 8 of the
Investment Company Act of 1940.
(e) [ ] Investment Adviser registered under Section 203 of
the Investment Advisers Act of 1940.
(f) [ ] Employee Benefit Plan, Pension Fund which is subject
to the provisions of the Employee Retirement Income
Security Act of 1974 or Endowment Fund; see Rule
13d-1(b)(1)(ii)(F) of the Act.
(g) [ ] Parent Holding Company, in accordance with Rule
13d-1(b)(ii)(G) of the Act.
(h) [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(H) of
the Act.
None of the above.
Item 4. Ownership.
----------
(a) Amount Beneficially Owned: As of December 31, 1998, each
of the following is the owner of record of the number of
shares of Common Stock set forth next to his, her or its
name:
OBP: 408,690 Shares
OBP Adjunct: 82,517 Shares
OBP Management: 0 Shares
OBP Bermuda: 113,378 Shares
OBP Management Bermuda: 0 Shares
Mr. Olivier: 0 Shares
Mr. Ryan: 0 Shares
Mr. Walton: 0 Shares
By virtue of their relationship as affiliated limited
partnerships, whose sole general partners share individual
general partners, OBP, OBP Adjunct and OBP Bermuda may be deemed
to share voting power and the power to direct the disposition of
the shares of Common Stock which each partnership owns of
record. Messrs. Ryan, Walton and Olivier are general partners of
both OBP Management, the general partner of OBP and OBP Adjunct,
and OBP Bermuda Management, the general partner OBP Bermuda.
Therefore, each of Messrs. Ryan, Walton and Olivier may be
deemed to own beneficially the shares held by OBP, OBP Adjunct
and OBP Bermuda.
(b) Percent of Class:
OBP: 9.4%
OBP Adjunct: 9.4%
OBP Management: 9.4%
OBP Bermuda: 9.4%
OBP Management Bermuda: 9.4%
Mr. Olivier: 9.4%
Mr. Ryan: 9.4%
Mr. Walton: 9.4%
The foregoing percentages are calculated based on the 6,422,872
shares of Common Stock reported to be outstanding as of October
31, 1998 in the Quarterly Report on Form 10-Q of Collaborative
Clinical Research, Inc. for the quarter ended September 30,
1998, as adjusted pursuant to Rule 13d-3 (d)(1) of the Act.
Page 11 of 19 pages
<PAGE>
- ---------------------------------- ---------------------------
|CUSIP NO. 194190 10 4 | 13G | Page 12 of 19 Pages |
| ------------ | | --- --- |
- ---------------------------------- ---------------------------
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote:
OBP: 0 Shares
OBP Adjunct: 0 Shares
OBP Management: 0 Shares
OBP Bermuda: 0 Shares
OBP Management Bermuda: 0 Shares
Mr. Olivier: 0 Shares
Mr. Ryan: 0 Shares
Mr. Walton: 0 Shares
(ii) shared power to vote or to direct the vote:
OBP: 604,585 Shares
OBP Adjunct: 604,585 Shares
OBP Management: 604,585 Shares
OBP Bermuda: 604,585 Shares
OBP Management Bermuda: 604,585 Shares
Mr. Olivier: 604,585 Shares
Mr. Ryan: 604,585 Shares
Mr. Walton: 604,585 Shares
(iii) sole power to dispose or to direct the disposition
of:
OBP: 0 Shares
OBP Adjunct: 0 Shares
OBP Management: 0 Shares
OBP Bermuda: 0 Shares
OBP Management Bermuda: 0 Shares
Mr. Olivier: 0 Shares
Mr. Ryan: 0 Shares
Mr. Walton: 0 Shares
(iv) shared power to dispose or to direct the disposition
of:
OBP: 604,585 Shares
OBP Adjunct: 604,585 Shares
OBP Management: 604,585 Shares
OBP Bermuda: 604,585 Shares
OBP Management Bermuda: 604,585 Shares
Mr. Olivier: 604,585 Shares
Mr. Ryan: 604,585 Shares
Mr. Walton: 604,585 Shares
Each of OBP, OBP Adjunct, OBP Management, OBP Bermuda, OBP
Management Bermuda, Mr. Olivier, Mr. Ryan and Mr. Walton
expressly disclaims beneficial ownership of any shares of Common
Stock of Collaborative Clinical Research, Inc., except any
shares held directly of record.
Item 5. Ownership of Five Percent or Less of a Class.
---------------------------------------------
If this statement is being filed to report the fact that as of
the date hereof the reporting person has ceased to be the
beneficial owner of more than five percent of the class of
securities, check the following: [ ]
Page 12 of 19 pages
<PAGE>
- ---------------------------------- ---------------------------
|CUSIP NO. 194190 10 4 | 13G | Page 13 of 19 Pages |
| ------------ | | --- --- |
- ---------------------------------- ---------------------------
Item 6. Ownership of More than Five Percent on Behalf of Another Person.
----------------------------------------------------------------
Not applicable.
Item 7. Identification and Classification of the Subsidiary Which
---------------------------------------------------------
Acquired the Security Being Reported on by the Parent Holding
-------------------------------------------------------------
Company.
--------
Not applicable.
Item 8. Identification and Classification of Members of the Group.
----------------------------------------------------------
Not applicable. OBP, OBP Adjunct, OBP Management, OBP Bermuda,
OBP Management Bermuda, Mr. Olivier, Mr. Ryan and Mr. Walton
expressly disclaim membership in a "group" as defined in Rule
13d-1(b)(ii)(H) of the Act.
Item 9. Notice of Dissolution of Group.
-------------------------------
Not applicable.
Item 10. Certification.
--------------
Not applicable. This statement on Schedule 13G is not filed
pursuant to Rule 13d-1(b) or Rule 13d-1(c).
Page 13 of 19 pages
<PAGE>
- ---------------------------------- ---------------------------
|CUSIP NO. 194190 10 4 | 13G | Page 14 of 19 Pages |
| ------------ | | --- --- |
- ---------------------------------- ---------------------------
Signature
After reasonable inquiry and to the best of his, her or its knowledge
and belief, each of the undersigned certifies that the information set forth in
this statement is true, complete and correct. We also hereby agree to file this
statement jointly pursuant to the agreement set forth as Exhibit 1 to our
initial Schedule 13G filing. ---------
Dated: February 12, 1999
OXFORD BIOSCIENCE PARTNERS L.P.
By: OBP Management L.P., its general partner
By: *
---------------------------------------------------------
Cornelius T. Ryan
General Partner
OXFORD BIOSCIENCE PARTNERS (ADJUNCT) L.P.
By: OBP Management L.P., its general partner
By: *
---------------------------------------------------------
Cornelius T. Ryan
General Partner
OXFORD BIOSCIENCE PARTNERS (BERMUDA) LIMITED
PARTNERSHIP
By: OBP Management (Bermuda) Limited Partnership, its general
partner
By: *
---------------------------------------------------------
Cornelius T. Ryan
General Partner
OBP MANAGEMENT L.P.
By: *
-------------------------------------------------------------
Cornelius T. Ryan
General Partner
OBP MANAGEMENT (BERMUDA) LIMITED PARTNERSHIP
By: *
-------------------------------------------------------------
Cornelius T. Ryan
General Partner
*
----------------------------------------------------------------
Cornelius T. Ryan
*
----------------------------------------------------------------
Alan G. Walton
Page 14 of 19 pages
<PAGE>
- ---------------------------------- ---------------------------
|CUSIP NO. 194190 10 4 | 13G | Page 15 of 19 Pages |
| ------------ | | --- --- |
- ---------------------------------- ---------------------------
*
----------------------------------------------------------------
Edmund M. Olivier
*
------------------------------------------------
Jeffrey M. Held
Attorney-in-Fact
This Schedule 13G was executed by Jeffrey M. Held pursuant to the Power
of Attorney filed with the Securities and Exchange Commission herewith as
Exhibit 1.
- ---------
Page 15 of 19 pages
<PAGE>
- ---------------------------------- ---------------------------
|CUSIP NO. 194190 10 4 | 13G | Page 16 of 19 Pages |
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Exhibit 1
---------
POWER OF ATTORNEY
KNOW ALL MEN BY THESE PRESENTS, that the person whose signature appears
below hereby constitutes and appoints Raymond N. Charest, Jeffrey M. Held, and
Amy B. Rensko, and any one of them acting singly, the true and lawful
attorneys-in-fact and agents, with full power of substitution and
resubstitution, for the undersigned and in the undersigned's name, place and
stead, in any and all capacities (until revoked in writing) to sign any and all
instruments, certificates and documents required to be executed on behalf of the
undersigned as an individual or on behalf of the undersigned's holding company,
as the case may be, pursuant to sections 13 and 16 of the Securities Exchange
Act of 1934, as amended (the "Exchange Act"), and any and all regulations
promulgated thereunder, and to file the same, with all exhibits thereto, and any
other documents in connection therewith, with the Securities and Exchange
Commission, and with any other entity when and if such is mandated by the
Exchange Act or by the By-laws of the National Association of Securities
Dealers, Inc. granting unto said attorneys-in-fact and agents full power and
authority to do and perform each and every act and thing requisite and necessary
fully to all intents and purposes as the undersigned might or could do in person
thereby ratifying and confirming all that said attorneys-in-fact and agents, or
their substitute or substitutes, may lawfully do or cause to be done by virtue
hereof. Notwithstanding the foregoing, this Power of Attorney shall expire
automatically upon the cessation of the undersigned's reporting obligations
pursuant to sections 13 and 16 of the Exchange Act or on the date that each
attorney-in-fact is no longer employed in their current capacities.
(REMAINDER OF PAGE LEFT INTENTIONALLY BLANK)
Page 16 of 19 pages
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|CUSIP NO. 194190 10 4 | 13G | Page 17 of 19 Pages |
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IN WITNESS WHEREOF, this Power of Attorney has been signed as of the
7th day of February, 1999.
OXFORD BIOSCIENCE PARTNERS L.P.
By: OBP Management L.P., its general partner
By: /s/ Cornelius T. Ryan
--------------------------------------------------------
Cornelius T. Ryan
General Partner
OXFORD BIOSCIENCE PARTNERS (BERMUDA) LIMITED PARTNERSHIP
By: OBP Management (Bermuda) Limited Partnership, its general
partner
By: /s/ Cornelius T. Ryan
--------------------------------------------------------
Cornelius T. Ryan
General Partner
OBP MANAGEMENT L.P.
By: /s/ Cornelius T. Ryan
--------------------------------------------------------
Cornelius T. Ryan
General Partner
OBP MANAGEMENT (BERMUDA) LTD.
By: /s/ Edmund M. Olivier
--------------------------------------------------------
Edmund M. Olivier
Director
OBP MANAGEMENT (BERMUDA) LIMITED PARTNERSHIP
By: /s/ Cornelius T. Ryan
--------------------------------------------------------
Cornelius T. Ryan
General Partner
OXFORD BIOSCIENCE PARTNERS (ADJUNCT), L.P.
By: OBP Management, L.P., its general partner
By: /s/ Cornelius T. Ryan
--------------------------------------------------------
Cornelius T. Ryan
General Partner
Page 17 of 19 pages
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|CUSIP NO. 194190 10 4 | 13G | Page 18 of 19 Pages |
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OXFORD BIOSCIENCE MANAGEMENT PARTNERS II
By: /s/ Cornelius T. Ryan
--------------------------------------------------------
Cornelius T. Ryan
General Partner
OXFORD BIOSCIENCE PARTNERS II L.P.
By: OBP Management II L.P., its general partner
By: /s/ Jonathan J. Fleming
--------------------------------------------------------
Jonathan J. Fleming
General Partner
OXFORD BIOSCIENCE PARTNERS (BERMUDA) II LIMITED PARTNERSHIP
By: OBP Management (Bermuda) II Limited Partnership, its
general partner
By: /s/ Jonathan J. Fleming
--------------------------------------------------------
Jonathan J. Fleming
General Partner
OBP MANAGEMENT II, L.P.
By: /s/ Jonathan J. Fleming
--------------------------------------------------------
Jonathan J. Fleming
General Partner
OBP MANAGEMENT (BERMUDA) II LIMITED PARTNERSHIP
By: OBP Management (Bermuda) II Ltd., its general partner
By: /s/ Jonathan J. Fleming
--------------------------------------------------------
Jonathan J. Fleming
Director
OXFORD BIOSCIENCE PARTNERS (ADJUNCT) II, L.P.
By: OBP Management II, L.P., its general partner
By: /s/ Jonathan J. Fleming
--------------------------------------------------------
Jonathan J. Fleming
General Partner
OBP MANAGEMENT (BERMUDA) II LTD.
By: /s/ Jonathan J. Fleming
--------------------------------------------------------
Jonathan J. Fleming
Director
OXFORD BIOSCIENCE PARTNERS (GS - ADJUNCT) II, L.P.
By: OBP Management II, L.P., its general partner
By: /s/ Jonathan J. Fleming
--------------------------------------------------------
Jonathan J. Fleming
General Partner
Page 18 of 19 pages
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|CUSIP NO. 194190 10 4 | 13G | Page 19 of 19 Pages |
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/s/ Cornelius T. Ryan
----------------------------------------------------------------
Cornelius T. Ryan
/s/ Alan G. Walton
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Alan G. Walton
/s/ Edmund M. Olivier
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Edmund M. Olivier
/s/ Jonathan J. Fleming
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Jonathan J. Fleming
Page 19 of 19 pages
