GERON CORPORATION
PRE 14A, 2000-03-31
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1

                                  SCHEDULE 14A
                                 (RULE 14A-101)

                    INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION
          PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE SECURITIES
                    EXCHANGE ACT OF 1934 (AMENDMENT NO.   )

Filed by the Registrant [X]

Filed by a Party other than the Registrant [ ]

Check the appropriate box:

<TABLE>
<S>                                             <C>
[X]  Preliminary Proxy Statement                [ ]  Confidential, for Use of the Commission
                                                     Only (as permitted by Rule 14a-6(e)(2))
[ ]  Definitive Proxy Statement
[ ]  Definitive Additional Materials
[ ]  Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12
</TABLE>
                               GERON CORPORATION
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

[X]  No fee required.

[ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

     (1)  Title of each class of securities to which transaction applies:

     (2)  Aggregate number of securities to which transaction applies:

     (3)  Per unit price or other underlying value of transaction computed
          pursuant to Exchange Act Rule 0-11 (set forth the amount on which the
          filing fee is calculated and state how it was determined):

     (4)  Proposed maximum aggregate value of transaction:

     (5)  Total fee paid:

[ ]  Fee paid previously with preliminary materials:

[ ]  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2) and identify the filing for which the offsetting fee was paid
     previously. Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.

     (1)  Amount Previously Paid:

     (2)  Form, Schedule or Registration Statement No.:

     (3)  Filing Party:

     (4)  Date Filed:
<PAGE>   2

                                   Geron logo

                               GERON CORPORATION
                             230 CONSTITUTION DRIVE
                              MENLO PARK, CA 94025

                            ------------------------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD ON MAY 26, 2000

TO THE STOCKHOLDERS OF GERON CORPORATION:

     NOTICE IS HEREBY GIVEN that the Annual Meeting of Stockholders of GERON
CORPORATION, a Delaware corporation (the "Company"), will be held on Friday, May
26, 2000, at 9:00 a.m. local time at the company headquarters, 230 Constitution
Drive, Menlo Park, California 94025 for the following purposes:

          1. To elect the three Class I Directors to serve for a term of three
     years, or until their successors are elected.

          2. To approve an amendment to the Company's Restated Certificate of
     Incorporation to increase the number of authorized shares of Common Stock
     from 35,000,000 shares to 50,000,000 shares.

          3. To approve an amendment to the Company's 1992 Stock Option Plan to
     increase the aggregate number of shares of Common Stock authorized for
     issuance under such Plan by 500,000 shares.

          4. To ratify the selection of Ernst & Young LLP as independent
     auditors of the Company for the fiscal year ending December 31, 2000.

          5. To transact such other business as may properly come before the
     meeting or any adjournment or postponement thereof.

     The foregoing items of business, including the nominees for Class I
Directors, are more fully described in the Proxy Statement accompanying this
Notice.

     The Board of Directors has fixed the close of business on Monday, March 27,
2000, as the record date for the determination of stockholders entitled to
notice of and to vote at this Annual Meeting and at any adjournment or
postponement thereof.

     All stockholders are cordially invited to attend the meeting in person.
Whether or not you expect to attend the meeting, please complete, date, sign and
return the enclosed proxy as promptly as possible in order to ensure your
representation at the meeting. A return envelope (which is postage prepaid if
mailed in the United States) is enclosed for that purpose. Even if you have
given your proxy, you may still vote in person if you attend the meeting. Please
note, however, that if your shares are held of record by a broker, bank or other
nominee and you wish to vote at the meeting, you must obtain from the record
holder a proxy issued in your name.

                                      By Order of the Board of Directors

                                      /s/ David L. Greenwood
                                      David L. Greenwood
                                      Secretary

Menlo Park, California
April   , 2000

     YOUR VOTE IS VERY IMPORTANT, REGARDLESS OF THE NUMBER OF SHARES YOU OWN.
PLEASE READ THE ATTACHED PROXY STATEMENT CAREFULLY, COMPLETE, SIGN AND DATE THE
ENCLOSED PROXY CARD AS PROMPTLY AS POSSIBLE AND RETURN IT IN THE ENCLOSED
ENVELOPE.
<PAGE>   3

                               GERON CORPORATION
                             230 CONSTITUTION DRIVE
                              MENLO PARK, CA 94025
                            ------------------------

                                PROXY STATEMENT
                            ------------------------

                 INFORMATION CONCERNING SOLICITATION AND VOTING

GENERAL

     The enclosed proxy is solicited on behalf of the Board of Directors of
Geron Corporation, a Delaware corporation (the "Company") for use at the Annual
Meeting of Stockholders to be held on May 26, 2000, at 9:00 a.m. local time (the
"Annual Meeting"), or at any adjournment or postponement thereof, for the
purposes set forth herein and in the accompanying Notice of Annual Meeting. The
Annual Meeting will be held at the company headquarters, 230 Constitution Drive,
Menlo Park, California 94025. The Company intends to mail this proxy statement
and accompanying proxy card on or about April 17, 2000 to all stockholders
entitled to vote at the Annual Meeting.

SOLICITATION

     The Company will bear the entire cost of solicitation of proxies including
preparation, assembly, printing and mailing of this proxy statement, the proxy
and any additional information furnished to stockholders. Copies of solicitation
materials will be furnished to banks, brokerage houses, fiduciaries and
custodians holding in their names shares of Common Stock beneficially owned by
others to forward to such beneficial owners. In addition, the Company may
reimburse persons representing beneficial owners of Common Stock for their costs
of forwarding solicitation materials to such beneficial owners. The original
solicitation of proxies by mail may be supplemented by telephone, telegram or
personal solicitation by directors, officers, or other regular employees of the
Company or, at the Company's request, Corporate Investor Communications, Inc. No
additional compensation will be paid to directors, officers or other regular
employees for such services, but Corporate Investor Communications, Inc. will be
paid its customary fee, estimated to be $5,500, if it renders solicitation
services.

VOTING RIGHTS AND OUTSTANDING SHARES

     Only holders of record of Common Stock at the close of business on Monday,
March 27, 2000, (the "Record Date") will be entitled to notice of and to vote at
the Annual Meeting. At the close of business on the Record Date, the Company had
outstanding and entitled to vote 21,423,687 shares of Common Stock. Each holder
of record of Common Stock on such date will be entitled to one vote for each
share held on all matters to be voted upon at the Annual Meeting.

     All votes will be tabulated by the inspector of election appointed for the
meeting, who will separately tabulate affirmative and negative votes,
abstentions and broker non-votes. Abstentions will be counted towards the
tabulation of votes cast on proposals presented to the stockholders and will
have the same effect as negative votes. Broker non-votes are counted towards a
quorum, except with respect to Proposal 2, but are not counted for any purpose
in determining whether a particular matter has been approved. With respect to
Proposal 2, broker non-votes will have the same effect as negative votes.

VOTING VIA THE INTERNET OR BY TELEPHONE

     Most beneficial owners whose stock is held in street name receive voting
instruction forms from their banks, brokers, or other agents, rather than the
Company's proxy card.

     A number of brokers and banks are participating in a program provided
through ADP Investor Communication Services that offers telephone and Internet
voting options. If your shares are held in an account with a broker or bank
participating in the ADP Investor Communication Services program, you may
<PAGE>   4

vote those shares telephonically by calling the telephone number shown on the
voting form received from your broker or bank, or via the Internet at ADP
Investor Communication Services' voting web site http://www.proxyvote.com.

     Submitting your proxy via the Internet or by telephone will not affect your
right to vote in person should you decide to attend the Annual Meeting.

     The telephone and Internet voting procedures are designed to authenticate
stockholders' identities, to allow stockholders to give their voting
instructions and to confirm that stockholders' instruction have been recorded
properly. Stockholders voting via the Internet should understand that there may
be costs associated with electronic access, such as usage charges from Internet
access providers and telephone companies, that must be borne by the stockholder.

REVOCABILITY OF PROXIES

     Any person giving a proxy pursuant to this solicitation has the power to
revoke it at any time before it is voted. It may be revoked by filing with the
Secretary of the Company at the Company's offices, 230 Constitution Drive, Menlo
Park, California 94025, a written notice of revocation or a duly executed proxy
bearing a later date, or it may be revoked by attending the meeting and voting
in person. Attendance at the meeting will not, by itself, revoke a proxy.

STOCKHOLDER PROPOSALS

     Proposals of stockholders that are intended to be presented at the
Company's 2001 Annual Meeting of Stockholders must be received by the Company
not later than January 10, 2001 in order to be included in the proxy statement
and proxy relating to that Annual Meeting. Stockholders wishing to submit
proposals or director nominations that are to be included in such proxy
statement and proxy must do so not less than 10 nor more than 60 days prior to
the date of the meeting.

              MATTERS TO BE CONSIDERED AT THE 2000 ANNUAL MEETING

                                   PROPOSAL 1

                             ELECTION OF DIRECTORS

     Geron has three classes of director; serving staggered three-year terms.
Class I consists of three directors who will be elected at this Annual Meeting.
Class II consists of three directors who will be elected at the 2001 Annual
Meeting. Class III consists of two directors who will be elected at the 2002
Annual Meeting. At this Annual Meeting, the Class I Directors are to be elected
for three-year terms expiring on the date of the Annual Meeting in 2003 or until
their successors are elected and qualified. The Board of Directors has selected
three nominees for Class I Directors, all of whom are currently directors of the
Company. The three candidates receiving the highest number of affirmative votes
of the shares represented and entitled to vote at the Annual Meeting will be
elected as Class I Directors of the Company.

                                 REQUIRED VOTE

     Stockholders are requested in this Proposal 1 to approve each nominee for
Class I Director. The affirmative vote of a majority of the shares present in
person or represented by proxy and entitled to vote on the proposal at the
meeting will be required to elect the nominees.

                                        2
<PAGE>   5

     Shares represented by executed proxies will be voted, if authority to do so
is not withheld, for the election of the three nominees named below. In the
event that any nominee should be unavailable for election as a result of an
unexpected occurrence, such shares will be voted for the election of such
substitute nominee as management may propose. Each person nominated for election
has agreed to serve if elected, and management has no reason to believe that any
nominee will be unable to serve.

    THE BOARD OF DIRECTORS RECOMMENDS A VOTE IN FAVOR OF EACH NAMED NOMINEE

     Set forth below is information regarding the nominees for Class I Director,
the periods during which they have served as directors, and information
furnished by them as to principal occupations and directorships held by them in
corporations whose shares are publicly registered.

NOMINEES FOR CLASS I DIRECTORS (TERM ENDING IN 2000)

<TABLE>
<CAPTION>
                   NAME                     AGE   PRINCIPAL OCCUPATION/POSITION WITH THE COMPANY
                   ----                     ---   ----------------------------------------------
<S>                                         <C>   <C>
Gary L. Neil, Ph.D. ......................  59    President and Chief Executive Officer,
                                                  Crescendo Pharmaceutical Corp.
Thomas B. Okarma, Ph.D., M.D. ............  54    President and Chief Executive Officer
John P. Walker............................  51    President and Chief Executive Officer, Axys
                                                  Pharmaceuticals, Inc.
</TABLE>

     GARY L. NEIL, PH.D., has served as a Director of the Company since
September 1998. Dr. Neil is also a director of Crescendo Pharmaceutical
Corporation, Allergen Specialty Therapeutics, Inc. and Signal Pharmaceuticals,
Inc. He also has been the President and Chief Executive Officer of Crescendo
Pharmaceuticals since its inception in September 1997. From 1993 to 1997, he was
the President and Chief Executive Officer of Therapeutic Discovery Corporation
which was formed by ALZA Corporation and purchased by them in 1997. From 1989 to
1993, Dr. Neil served as Executive Vice President of American Home Products'
subsidiary Wyeth-Ayerst Research where he led Wyeth-Ayerst's worldwide
pharmaceutical research and development organization. Prior to joining American
Home Products, Dr. Neil served 23 years at The Upjohn company in a number of
scientific and management positions. Dr. Neil holds a B.Sc. in Chemistry from
Queen's University, Canada and a Ph.D. in Organic Chemistry from California
Institute of Technology.

     THOMAS B. OKARMA, PH.D., M.D., has served as Geron's President, Chief
Executive Officer and Director since July 1999. He is also a director of Geron
Bio-Med Limited, a United Kingdom company. From May 1998 until July 1999, Dr.
Okarma was Vice President of Research and Development. From December 1997 until
May 1998, Dr. Okarma was Vice President of Cell Therapies. From 1985 until
joining Geron, Dr. Okarma, the scientific founder of Applied Immune Sciences,
Inc., served initially as its Vice President of Research and Development and
then as its Chairman and Chief Executive Officer until 1995 when it was acquired
by Rhone-Poulenc Rorer. Dr. Okarma was a Senior Vice President at Rhone-Poulenc
Rorer from the time of the acquisition of Applied Immune Sciences, Inc. until
December 1996. From 1980 to 1985, Dr. Okarma was a member of the faculty of the
Department of Medicine at Stanford University School of Medicine. Dr. Okarma
holds a A.B. from Dartmouth College and a M.D. and Ph.D. from Stanford
University.

     JOHN P. WALKER has served as a Director of the Company since April 1997. He
is currently Chairman and Chief Executive Officer and a director of Axys
Pharmaceuticals, Inc., which is the corporation that resulted from the merger of
Arris Pharmaceutical Corporation and Sequana Therapeutics, Inc. Mr. Walker is
also a director of Microcide Pharmaceuticals. From 1993 to 1997, he was
President, Chief Executive Officer and a director of Arris Pharmaceutical
Corporation. Prior to his association with Arris, Mr. Walker was the Chairman
and Chief Executive Officer of Vitaphore Corporation, a biomaterials company
that was sold to Union Carbide Chemicals and Plastics Company Inc. in 1990. From
1971 to 1985, Mr. Walker was employed by American Hospital Supply Corporation in
a variety of general management, sales and marketing positions, most recently
serving as President of the American Hospital Company. He holds a B.A. from the
State University of New York at Buffalo and conducted graduate business studies
at Northwestern University Institute for Management.

                                        3
<PAGE>   6

CONTINUING DIRECTORS

     Set forth below is information regarding the continuing Class II and Class
III Directors of the Company, including their ages, the periods during which
they have served as directors, and information furnished by them as to principal
occupations and directorships held by them in corporations whose shares are
publicly registered.

CLASS II DIRECTORS (TERM ENDING IN 2001)

<TABLE>
<CAPTION>
                   NAME                     AGE   PRINCIPAL OCCUPATION/POSITION WITH THE COMPANY
                   ----                     ---   ----------------------------------------------
<S>                                         <C>   <C>
Ronald W. Eastman.........................  47    President, EdeNet Communications, Inc.
Thomas D. Kiley, Esq......................  56    Attorney-at-law
Edward V. Fritzky.........................  49    Chief Executive Officer and Chairman, Immunex
                                                  Corporation
</TABLE>

     RONALD W. EASTMAN has served as a Director of the Company since May 1993.
He is President of EdeNet Communications, Inc., a company providing internet and
intranet based educational and entertainment services to hospital patients and
physicians. From May 1993 to July 1999, Mr. Eastman served as President and
Chief Executive Officer of the Company. From 1978 until May 1993, Mr. Eastman
was employed with American Cyanamid Co., most recently as a Vice President and
General Manager of Lederle Laboratories, American Cyanamid's pharmaceutical
business. Mr. Eastman holds a B.A. from Williams College and an M.B.A. from
Columbia University.

     THOMAS D. KILEY, ESQ., has served as a Director of the Company since
September 1992. Mr. Kiley is also a director Pharmacyclics, Inc., Connetics
Corp., Cardiogenesis Corporation and certain privately held biotechnology and
other companies. He has been self-employed since 1988 as an attorney,
consultant, and investor. From 1980 to 1988, he was an officer of Genentech,
Inc., a biotechnology company, serving variously as Vice President and General
Counsel, Vice President for Legal Affairs and Vice President for Corporate
Development. From 1969 to 1980, he was with the Los Angeles law firm of Lyon &
Lyon and was a partner at the firm from 1975 to 1980. Mr. Kiley holds a B.S. in
Chemical Engineering from Pennsylvania State University and a J.D. from George
Washington University.

     EDWARD V. FRITZKY has served as a Director of the Company since July 1998.
He has served as Chief Executive Officer and Chairman of Immunex Corporation
since January 1994. Mr. Fritzky is also a director of Sonosite, Inc. Mr. Fritzky
served as President of Lederle Laboratories, a division of American Cyanamid,
from 1992 to 1994, and as Vice President of Lederle Laboratories from 1989 to
1992. Prior to joining Lederle Laboratories, Mr. Fritzky was an executive of
Searle Pharmaceuticals, Inc., a subsidiary of the Monsanto Company. During his
tenure at Searle, Mr. Fritzky was Vice President of Marketing in the United
States, and later President and General Manager of Searle Canada, Inc. and Lorex
Pharmaceuticals, a joint venture company. Mr. Fritzky holds a B.A. from Duquesne
University and is a graduate of the Advanced Executive Program, J.L. Kellogg
Graduate School of Management at Northwestern University.

CLASS III DIRECTORS (TERM ENDING IN 2002)

<TABLE>
<CAPTION>
                   NAME                     AGE   PRINCIPAL OCCUPATION/POSITION WITH THE COMPANY
                   ----                     ---   ----------------------------------------------
<S>                                         <C>   <C>
Alexander E. Barkas, Ph.D. ...............  52    General Partner, Prospect Venture Partners
Robert B. Stein, M.D., Ph.D. .............  49    Executive Vice President, Research &
                                                  Preclinical Development, DuPont
                                                  Pharmaceuticals
</TABLE>

     ALEXANDER E. BARKAS, PH.D., has served as Chairman of the Board since July
1993 and as a Director of the Company since March 1992. Dr. Barkas is also a
director of Connetics Corp. and several privately held medical technology
companies. From March 1992 until May 1993, he served as President and Chief
Executive Officer of the Company. He is a founding partner of Prospect Venture
Partners, a venture capital investment firm formed in October 1997. Dr. Barkas
was a partner with Kleiner Perkins Caufield & Byers, a venture capital
investment firm, from 1991 to October 1997. He holds a B.A. from Brandeis
University and Ph.D. from New York University.

                                        4
<PAGE>   7

     ROBERT B. STEIN, M.D., PH.D., has served as a Director of the Company since
April 1996. Since September 1996 Dr. Stein has been Executive Vice President of
Research & Preclinical Development at DuPont Pharmaceuticals. From August 1993
to September 1996, Dr. Stein was Senior Vice President and Chief Scientific
Officer of Ligand Pharmaceuticals, Inc., a pharmaceutical company, and from May
1990 to August 1993, he was Vice President of Research at Ligand. From 1982 to
1990, Dr. Stein held various positions with Merck, Sharp, and Dohme Research
Laboratories, a pharmaceutical company, including Senior Director and Head of
the Department of Pharmacology from 1989 to 1990. Dr. Stein holds a B.S. in
Biology and Chemistry from Indiana University and an M.D. and a Ph.D. in
Physiology and Pharmacology from Duke University.

     There are no family relationships among executive officers or directors of
the Company.

BOARD COMMITTEES AND MEETINGS

     During the fiscal year ended December 31, 1999, the Board of Directors held
seven meetings. The Board has an Audit Committee, a Compensation Committee and a
Stock Option Committee. During the fiscal year ended December 31, 1999, all
directors attended at least 75% of the meetings of the Board and the committees,
on which he served, during the period for which he was a director or committee
member, respectively.

     The Audit Committee meets with the Company's independent auditors at least
annually to review the results of the annual audit and discuss the financial
statements; recommends to the Board the independent auditors to be retained; and
receives and considers the auditors' comments as to financial controls, adequacy
of staff, as well as management performance and procedures in connection with
the annual audit. The Audit Committee, which is comprised of Dr. Barkas and Mr.
Kiley, met in April 1999 in connection with the audit of the 1998 financial
statements.

     The Compensation Committee makes recommendations concerning salaries and
incentive compensation, administers the incentive compensation and benefit plans
of the Company, and performs such other functions regarding compensation as the
Board may delegate. In addition, the Compensation Committee has exclusive
authority to administer the 1992 Stock Option Plan with respect to executive
officers and directors. The Compensation Committee, which is comprised of Dr.
Barkas and Mr. Walker, met five times during fiscal 1999 and acted by written
consent on four occasions during fiscal 1999.

     The Stock Option Committee was formed in December 1996 in order to provide
timely option grants to new employees and consultants (other than executive
officers and directors of the Company) and currently consists of one member, Dr.
Okarma. The Stock Option Committee has limited authority to administer the
Company's 1992 Stock Option Plan concurrently with the Compensation Committee.
The Stock Option Committee has the authority to grant options for up to 20,000
shares of Common Stock to employees and consultants in accordance with
procedures approved by the Board of Directors. The Stock Option Committee acted
by written consent on 15 occasions during fiscal 1999.

COMPENSATION OF DIRECTORS

     Directors currently receive $1,000 for each board meeting attended and are
reimbursed for out-of-pocket expenses incurred in connection with attendance at
meetings of the Board of Directors.

     Each non-employee director received periodic option grants for shares of
Common Stock pursuant to the Company's 1996 Directors' Stock Option Plan, as
amended (the "Directors Plan"). The Directors Plan is designed to work
automatically and not to require administration; however, to the extent
administration is necessary, it will be provided by the Board of Directors.

     The purpose of the Directors Plan is to provide an incentive for directors
to continue to serve the Company as directors and to assist the Company in
recruiting highly qualified individuals when vacancies occur on the Board of
Directors.

                                        5
<PAGE>   8

  TERMS OF OPTIONS

     The following is a description of the principal terms of options granted
under the Directors Plan.

     Option Grants. The Directors Plan provides that each person who becomes a
non-employee director after the effective date of the Directors Plan shall be
automatically granted a First Option to purchase 35,000 shares of Common Stock
on the date on which such person first becomes a non-employee director, whether
through election by the stockholders of the Company or appointment by the Board
of Directors to fill a vacancy. A Subsequent Option granted to non-employee
directors, other than the Chairman of the Board of Directors, to purchase 5,000
shares is automatically granted under the Directors Plan to each non-employee
director on the anniversary date of the election of the non-employee director to
the Board. The Subsequent Option granted to the Chairman of the Board of
Directors is for 10,000 shares. In the event that a director terminates his or
her service to the Board of Directors prior to the next anniversary date of his
or her election or appointment, he or she will be granted a prorated Subsequent
Option reflecting the period of service since the last anniversary date. A
Re-election Option to purchase 15,000 shares is granted to each non-employee
director upon such director's re-election to a subsequent three-year term on the
Board of Directors.

     The Directors Plan provides for neither a maximum nor a minimum number of
shares subject to options that may be granted to any one non-employee director,
but does provide for the number of shares that may be included in any grant and
the method of making a grant. No option granted under the Directors Plan is
transferable by the optionee other than by will or the laws of descent or
distribution or pursuant to the terms of a qualified domestic relations order
(as defined by the Internal Revenue Code of 1986, as amended (the "Code")), and
each option is exercisable, during the lifetime of the optionee, only by such
optionee.

     The Directors Plan provides that each First Option granted thereunder
becomes exercisable in installments cumulatively as to one-third of the shares
subject to the First Option on each of the first, second and third anniversaries
of the date of grant of the First Option, as to 100% of the Shares subject to
each Subsequent Option on the date of grant of each Subsequent Option and in
installments cumulatively as to one-third of shares subject to each Re-election
Option on each of the first, second and third anniversaries of the date of grant
of such Re-election Option. The options remain exercisable for up to 90 days
following the optionee's termination of service as a director of the Company,
unless such termination is a result of death or disability, in which case the
options remain exercisable for up to a six-month period.

     Exercise Price and Term of Options. The exercise price of all stock options
granted under the Directors Plan shall be equal to the fair market value of a
share of the Company's Common Stock on the date of grant of the option, which is
defined to be the closing sale price of the Company's Common Stock on the Nasdaq
National Market on the date of grant. Options granted under the Directors Plan
have a term of ten years.

     During 1999, options to purchase 5,000 shares each were issued to Mr.
Fritzky, Mr. Kiley, Dr. Neil, Dr. Stein, and Mr. Walker in connection with their
anniversary dates under the Directors Plan. Options to purchase 10,000 shares
were issued to Dr. Barkas, as Chairman of the Board, in connection with his
anniversary date. Also during 1999, options to purchase 15,000 shares each were
issued to Dr. Stein and Dr. Barkas in connection with their re-election to the
Board at the 1999 Annual Meeting under the Directors Plan. In addition, options
to purchase 40,000 shares were issued to Dr. Barkas under the Company's 1992
Stock Option Plan in connection with his services to the Company as Chairman of
the Board.

     In April 1996, the Company entered into a Consulting Agreement with Thomas
D. Kiley, a Director of the Company, pursuant to which Mr. Kiley agreed to
provide such advice and consultation as reasonably requested by the Company to
its officers and scientists on the direction, implementation and operations of
its scientific programs, business plans and management of intellectual property.
As compensation for his services under this agreement, Mr. Kiley received an
option to purchase 7,352 shares of Common Stock at an exercise price of $2.04
per share, with monthly vesting over a five year period. Unless otherwise
terminated by either the Company or Mr. Kiley, this agreement will expire on
April 10, 2001.

     In April 1997, the Company entered into a Consulting Agreement with John P.
Walker, a Director of the Company, pursuant to which Mr. Walker agreed to
provide such advice and consultation as reasonably requested by the Company to
its officers and scientists on the direction, implementation and operations of
its
                                        6
<PAGE>   9

scientific programs and business plans. As compensation for his services under
this agreement, Mr. Walker received an option to purchase 10,000 shares of
Common Stock at an exercise price of $9.25 per share, with annual vesting over a
three year period. In addition, Mr. Walker will receive cash compensation in the
amount of $10,000 per year, payable quarterly. Unless otherwise terminated by
either the Company or Mr. Walker, this agreement will expire on April 3, 2000.

                                   PROPOSAL 2

      APPROVAL OF INCREASE IN NUMBER OF AUTHORIZED SHARES OF COMMON STOCK

     The Board of Directors has adopted, subject to stockholder approval, an
amendment to the Company's Restated Certificate of Incorporation to increase the
Company's authorized number of shares of Common Stock from 35,000,000 shares to
50,000,000 shares.

     The additional Common Stock to be authorized by adoption of the amendment
would have rights identical to the currently outstanding Common Stock of the
Company. Adoption of the proposed amendment and issuance of the Common Stock
would not affect the rights of the holders of currently outstanding Common
Stock, except for effects incidental to increasing the number of shares of the
Common Stock outstanding, such as dilution of the earnings per share and voting
rights of current holders of Common Stock. If the amendment is adopted, it will
become effective upon filing of a Certificate of Amendment of the Company's
Restated Certificate of Incorporation, in the form of Appendix 1 hereto, with
the Secretary of State of the State of Delaware.

     In addition to the 21,423,687 shares of Common Stock outstanding at March
27, 2000, the Board has reserved 4,072,689 shares for issuance upon exercise of
options and rights granted under the Company's stock option and stock purchase
plans, up to approximately 1,973,238 shares of Common Stock which may be issued
upon conversion of outstanding debentures, exercise of warrants and future
milestone obligations.

     Although at present the Board of Directors has no plans to issue additional
shares of Common Stock other than as described above, it desires to have such
shares available to provide additional flexibility to use its capital stock for
business and financial purposes in the future. The additional shares may be
used, without further stockholder approval, for various purposes including,
without limitation, raising capital, providing equity incentives to employees,
officers or directors, establishing strategic relationships with other companies
and expanding the Company's business through the acquisition of other businesses
or technologies.

     The additional shares of Common Stock that would become available for
issuance if the proposal were adopted could also be used by the Company to
oppose a hostile takeover attempt or delay or prevent changes in control or
management of the Company. For example, without further stockholder approval,
the Board could adopt a "poison pill" which would, under certain circumstances
related to an acquisition of shares not approved by the Board of Directors, give
certain holders the right to acquire additional shares of Common Stock at a low
price, or the Board could strategically sell shares of Common Stock in a private
transaction to purchasers who would oppose a takeover or favor the current
Board. Although this proposal to increase the authorized Common Stock has been
prompted by business and financial considerations and not by the threat of any
hostile takeover attempt (nor is the Board currently aware of any such attempts
directed at the Company), nevertheless, stockholders should be aware that
approval of this proposal could facilitate future efforts by the Company to
deter or prevent changes in control of the Company, including transactions in
which the stockholders might otherwise receive a premium for their shares over
then current market prices.

                                 REQUIRED VOTE

     Stockholders are requested in this Proposal 2 to approve this amendment to
the Company's Restated Certificate of Incorporation. The affirmative vote of the
holders of a majority of the shares present in person or represented by proxy
and entitled to vote on the proposal at the meeting will be required to approve
the proposal.

        THE BOARD OF DIRECTORS RECOMMENDS A VOTE IN FAVOR OF PROPOSAL 2
                                        7
<PAGE>   10

                                   PROPOSAL 3

              APPROVAL OF AMENDMENT TO THE 1992 STOCK OPTION PLAN

     The Company's stockholders are being asked to approve an amendment to the
Company's 1992 Stock Option Plan, as amended (the "Stock Option Plan") to
increase the number of shares issuable thereunder by 500,000 shares. In March
2000, the Board amended the Stock Option Plan, subject to stockholder approval,
to increase the aggregate number of shares authorized for issuance under the
Stock Option Plan from 5,444,362 to 5,944,362 The Board adopted the amendment to
ensure that the Company can continue to grant stock options, at levels
determined appropriate by the Board, to attract and retain qualified employees
and consultants.

     The Stock Option Plan was initially adopted by the Board of Directors in
May 1992 and approved by the stockholders in July 1992 and has been amended
several times since then. As of December 31, 1999, a total of 5,144,362 shares
of Common Stock had been authorized for issuance under the Stock Option Plan
with an automatic increase on the first trading day of the 1998, 1999, 2000 and
2001 calendar years of an additional number of shares equal to 2% of the number
of shares of Common Stock outstanding on December 31 of the immediately
preceding calendar year, with no such annual increase to exceed 300,000 shares.
Taking into account the annual increase for 2000, a total of 5,444,362 shares of
Common Stock have been authorized for issuance under the Stock Option Plan as of
the date of this Proxy Statement.

     As of March 27, 2000, options to purchase a total of 2,875,410 shares were
outstanding under the Stock Option Plan (net of canceled or expired options),
and 752,029 shares remained available for future grants under the Stock Option
Plan. As of March 27, 2000, the aggregate fair market value of shares subject to
outstanding options under the Stock Option Plan was $92,372,546, based upon the
closing price of the Common Stock on the Nasdaq National Market.

SUMMARY OF 1992 STOCK OPTION PLAN

     The following is a summary of the principal features of the Stock Option
Plan, together with the applicable tax implications, which will be in effect if
the proposed amendment to the Stock Option Plan is approved. The summary,
however, does not purport to be a complete description of all the provisions of
the Stock Option Plan. Any stockholder of the Company who wishes to obtain a
copy of the actual plan document may do so upon written request to the Secretary
of the Company at the Company's principal executive offices at 230 Constitution
Drive, Menlo Park, California 94025.

  GENERAL

     The Stock Option Plan provides for grants to employees of the Company and
any subsidiary of the Company (including officers and employee directors) of
"incentive stock options" ("ISO's") within the meaning of Section 422 of the
Internal Revenue Code of 1986, as amended (the "Code"), and for grants of
nonstatutory stock options ("NSO's") to employees (including officers and
employee directors) and consultants (including non-employee directors) of the
Company or any affiliate of the Company. As of March 27, 2000, five executive
officers and approximately 110 other employees and consultants (including
non-employee directors) were eligible to participate in the Stock Option Plan.
See "Federal Income Tax Aspects" below for information concerning the tax
treatment of incentive stock options and nonstatutory stock options.

     The Stock Option Plan is not a qualified deferred compensation plan under
Section 401(a) of the Code, and is not subject to the provisions of the Employee
Retirement Income Security Act of 1974, as amended ("ERISA").

  PURPOSE

     The purposes of the Stock Option Plan are to attract and retain the best
available personnel for positions of substantial responsibility, to give
employees and consultants of the Company a greater personal stake in the success
of the Company's business, to provide additional incentive to the employees and
consultants of the
                                        8
<PAGE>   11

Company to continue and advance in their employment and service to the Company
and to promote the success of the Company's business.

  ADMINISTRATION

     The Stock Option Plan is administered by the Company's Board of Directors
or a committee of the Board (the "Administrator"). The Stock Option Plan is
currently being administered by the Compensation Committee and the Stock Option
Committee of the Board of Directors with review by the entire Board of
Directors. With respect to executive officers and directors of the Company
(including executive officers who are also directors), the Stock Option Plan
will be administered exclusively by the Compensation Committee of the Board of
Directors. The Administrator may determine the terms of the options granted,
including the exercise price, the number of shares subject to each option and
the exercisability of the option. The Administrator also has the authority to
select the individuals to whom options will be granted and to make any
combination of grants to individuals. The Administrator's interpretation and
construction of any provision of the Stock Option Plan are final and binding
upon all participants. Members of the Board receive no additional compensation
for their services in connection with the administration of the Stock Option
Plan.

  ELIGIBILITY

     The Stock Option Plan provides that incentive stock options may be granted
only to employees (including officers and employee directors) of the Company or
any affiliate of the Company, while nonstatutory stock options may be granted
not only to employees (including officers and employee directors), but also
consultants (including non-employee directors) of the Company or any affiliate
of the Company. The Administrator shall have full authority to determine which
eligible individuals are to receive option grants under the Plan, the number of
shares to be covered by each such grant, whether the granted option is to be an
incentive stock option which satisfies the requirements of Section 422 of the
Code or a nonstatutory stock option not intended to meet such requirements, the
time or times at which each such option is to become exercisable, and the
maximum term for which the option is to remain outstanding.

     The Stock Option Plan provides that the maximum number of shares of Common
Stock which may be granted under options to any one employee during any fiscal
year shall be 500,000 shares subject to adjustment as provided in the Stock
Option Plan. There is also a limit on the aggregate market value of shares
subject to all incentive stock options that may be granted to an optionee during
any calendar year.

  STOCK SUBJECT TO THE STOCK OPTION PLAN

     An aggregate of 5,444,362 shares (5,944,362 shares assuming the proposed
amendment is approved) of Common Stock has been authorized for issuance under
the Stock Option Plan, as amended, including the automatic annual increase for
2000. If stock option awards granted under the Stock Option Plan expire or
otherwise terminate without being exercised, the shares of Common Stock not
purchased pursuant to such award again become available for issuance under the
Stock Option Plan.

  TERMS OF OPTIONS

     The following is a description of the permissible terms of options under
the Stock Option Plan. Individual option grants may be more restrictive as to
any or all of the permissible terms described below.

     Exercise Price; Payment. The exercise price under the Stock Option Plan is
determined by the Administrator and in the case of all incentive stock options
granted under the Stock Option Plan the exercise price must be at least equal to
the fair market value of the Common Stock of the Company on the date of grant.
The exercise price of all nonstatutory stock options must equal at least 85% of
the fair market value of the Common Stock on the date of grant. The exercise
price of any incentive stock option granted to an optionee who owns stock
representing more than 10% of the total combined voting power of all classes of
stock of the Company or any of its subsidiaries (a "10% Stockholder") must equal
at least 110% of the fair market value of the Common Stock on the date of grant.
At March 27, 2000, the closing sales price of a share of the Company's Common
Stock as reported on the Nasdaq National Market was $32.13 per share.
                                        9
<PAGE>   12

     The consideration to be paid for shares issued on exercise of options
granted under the Stock Option Plan, including the method of payment, is
determined by the Administrator and may consist entirely of cash, check,
promissory note, shares of the Company's Common Stock which have been
beneficially owned by the optionee for at least six months or which were not
acquired directly or indirectly from the Company, with a fair market value on
the exercise date equal to the aggregate exercise price of the shares purchased,
authorization from the Company to retain from the total number of shares as to
which the option is exercised a number of shares having a fair market value on
the exercise date equal to the aggregate exercise price of the shares issued, or
delivery of a properly executed notice and irrevocable instructions to a broker
to deliver promptly to the Company the amount of sale or loan proceeds required
to pay the exercise price. The Administrator may also authorize payments by any
combination of the above methods or any other consideration and method of
payment permitted by law.

     Option Exercise. Each option may be exercised during the lifetime of the
optionee only by such optionee or in the case of a nonstatutory stock option by
a transferee under a qualified domestic relations order. Options granted under
the Stock Option Plan generally vest in a series of installments at the rate of
12.5% of the total number of shares after the six month period from the date of
grant, and approximately 2.08% each month thereafter. Under certain
circumstances, options may be exercised prior to vesting, subject to the
Company's right to repurchase shares subject to such option at the exercise
price paid per share. The Company's repurchase rights would terminate on a
vesting schedule identical to the vesting schedule of the exercised option. In
addition, the Stock Option Plan provides that the Administrator, in its sole
discretion, may assist any optionee in the exercise of an option by authorizing
the extension of a loan from the Company to such optionee or by permitting such
optionee to pay the exercise price in installments over a period of years.

     Term. The Administrator determines the term of options. The term of a stock
option granted under the Stock Option Plan may not exceed ten years; provided,
however, that the term of an incentive stock option may not exceed five years
for 10% Stockholders.

     In the event an optionee ceases to be employed or retained by the Company
for any reason other than death or disability, each outstanding option held by
such optionee will remain exercisable for the three-month period following the
date of such cessation of employment or service. Should the optionee's
employment or service terminate by reason of disability, each outstanding option
will remain exercisable for the six month period following the date of such
cessation of employment. Should the disability be deemed a permanent disability
or should the optionee's employment terminate by reason of death, options held
by such optionee will remain exercisable for 12 months following such cessation
of employment or service. The Board will have full power and authority to extend
the period of time for which the option is to remain exercisable following the
optionee's termination of service.

  ADJUSTMENT PROVISIONS

     In the event any change is made to the Common Stock issuable under the
Stock Option Plan by reason of any stock split, stock dividend, combination of
shares, exchange of shares or other change affecting the outstanding Common
Stock as a class without receipt of consideration, appropriate adjustments shall
be made to (i) the aggregate number and/or class of shares issuable under the
Stock Option Plan, (ii) the maximum number of shares for which any one person
may be granted options per calendar year and (iii) the aggregate number and/or
class of shares and the option price per share in effect under each outstanding
option in order to prevent the dilution or enlargement of benefits thereunder.
The adjustments determined by the Administrator shall be final, binding and
conclusive.

  EFFECT OF CERTAIN CORPORATE EVENTS

     In the event of a transaction involving a change in control of the Company,
the Stock Option Plan provides that each outstanding option will accelerate so
that each option will be fully exercisable for all of the shares subject to such
option immediately prior to the effective date of the transaction. In addition,
upon the occurrence of such a transaction, the Stock Option Plan provides that
all of the outstanding repurchase rights

                                       10
<PAGE>   13

of the Company with respect to shares of Common Stock acquired upon exercise of
options granted under the Stock Option Plan will terminate.

  DURATION AND AMENDMENT

     Unless terminated sooner through action by the Board of Directors, the
Stock Option Plan shall terminate in 2002. The Board shall have complete and
exclusive power and authority to amend or modify the Stock Option Plan in any or
all respects whatsoever; provided, however, that no amendment or modification
shall, without the consent of the holders, adversely affect the rights and
obligations with respect to options outstanding under the Stock Option Plan; and
provided, further, that the Board shall not, without the approval of the
Company's stockholders, (i) increase the maximum number of shares issuable under
the Stock Option Plan or the maximum number of shares for which any person may
be granted options per calendar year, (ii) materially modify the eligibility
requirements for the grant of options under the Stock Option Plan, (iii)
materially increase the benefits accruing to Stock Option Plan participants or
(iv) increase the annual limitation on grants to participants under the Stock
Option Plan.

  RESTRICTIONS ON TRANSFER

     An option is nontransferable by the optionee other than by will or the laws
of descent and distribution, provided, however, that certain nonstatutory stock
options may be transferable. An option is exercisable during the optionee's
lifetime only by the optionee or permitted transferee and in the event of the
optionee's death, by a person who acquires the right to exercise the option by
bequest or inheritance or by reason of death of the optionee or permitted
transferee.

  FEDERAL INCOME TAX ASPECTS

     The following is a brief summary of the U.S. federal income tax
consequences of transactions under the Stock Option Plan based on federal income
tax laws in effect as of the date of this Proxy Statement. This summary is not
intended to be exhaustive and does not address all matters which may be relevant
to a particular optionee based on his or her specific circumstances. The summary
addresses only current U.S. federal income tax law and expressly does not
discuss the income tax law of any state, municipality or non-U.S. taxing
jurisdiction or gift, estate or other tax laws other than federal income tax
law. The Company advises all participants under the Stock Option Plan to consult
their own tax advisors concerning tax implications of options grants and
exercises and the disposition of stock acquired upon such exercises under the
Stock Option Plan.

     Options granted under the Stock Option Plan may be either "incentive stock
options," which are intended to qualify for the special tax treatment provided
by Section 422 of the Code, or nonstatutory stock options, which will not so
qualify.

     If an option granted under the Stock Option Plan is an incentive stock
option, the optionee will recognize no income upon grant of the incentive stock
option and incur no tax liability due to the exercise, except to the extent that
such exercise causes the optionee to incur alternative minimum tax (see
discussion below). The Company will not be allowed a deduction for federal
income tax purposes as a result of the exercise of an incentive stock option
regardless of the applicability of the alternative minimum tax. Upon the sale or
exchange of the shares acquired upon exercise more than two years after grant of
the option and one year after such exercise, any gain will be treated as
long-term capital gain. If both of these holding periods are not satisfied, the
optionee will recognize ordinary income equal to the difference between the
exercise price and the lower of the fair market value of the stock at the date
of the option exercise or the sale price of the stock. The Company will be
entitled to a deduction in the same amount as the ordinary income recognized by
the optionee. Any gain recognized on a disposition of the shares prior to
completion of both of the above holding periods in excess of the amount treated
as ordinary income will be characterized as long-term capital gain if the sale
occurs more than one year after exercise of the option or as short-term capital
gain if the sale is made earlier. For individual taxpayers, the current maximum
U.S. federal income tax on long-term capital gains is 20% (in the case of shares
held more than one year after exercise), whereas the maximum rate on other

                                       11
<PAGE>   14

income is 39.6%. Capital losses are allowed under U.S. tax laws in full against
capital gains plus $3,000 of other income.

     All other options which do not qualify as incentive stock options are
referred to as nonstatutory stock options. An optionee will not recognize any
taxable income under U.S. tax laws at the time he or she is granted a
nonstatutory stock option. However, upon its exercise, under U.S. tax laws the
optionee will recognize ordinary income for tax purposes measured by the excess
of the then fair market value of the shares over the exercise price. In certain
circumstances, where the shares are subject to a substantial risk of forfeiture
when acquired, the date of taxation under U.S. tax laws may be deferred unless
the optionee files an election with the Internal Revenue Service under Section
83(b) of the Code. The income recognized by an optionee who is also an employee
of the Company will be subject to income and employment tax withholding by the
Company by payment in cash by the optionee or out of the optionee's current
earnings. Upon resale of such shares by the optionee, any difference between the
sales price and the fair market value of the shares as of the date of exercise
of the option will be treated under U.S. tax laws as capital gain or loss, and
will qualify for long-term capital gain or loss treatment if the shares have
been held for more than one year from the date of exercise.

     The exercise of an incentive stock option may subject the optionee to
alternative minimum tax under Section 55 of the Code. The alternative minimum
tax is calculated by applying a tax rate of 26% to alternative minimum taxable
income of joint filers up to $175,000 ($87,500 for married taxpayers filing
separately) and 28% to alternative minimum taxable income above that amount.
Alternative minimum taxable income is equal to (i) taxable income adjusted for
certain items, plus (ii) items of tax preference less (iii) an exclusion of
$45,000 for joint returns or a surviving spouse, $33,750 for unmarried
individual returns and $22,500 in the case of married taxpayers filing
separately or an estate or trust (which exemption amounts are phased out for
upper income taxpayers). Alternative minimum tax will be due if the tax
determined under the foregoing formula exceeds the regular tax of the taxpayer
for the year.

     In computing alternative minimum taxable income, shares purchased upon
exercise of an incentive stock option are treated as if they had been acquired
by the optionee pursuant to exercise of a nonstatutory stock option. As a
result, the optionee recognizes alternative minimum taxable income equal to the
excess of the fair market value of the shares on the date of exercise over the
option's exercise price. Because the alternative minimum tax calculation may be
complex, any optionee who upon exercising an incentive stock option would
recognize (together with other alternative minimum taxable income preference and
adjustment items for the year) alternative minimum taxable income in excess of
the exclusion amount noted above should consult his or her own tax advisor prior
to exercising the incentive stock option.

     If an optionee pays alternative minimum tax, the amount of such tax may be
carried forward as a credit against any subsequent year's regular tax in excess
of the alternative minimum tax for such year.

  SECTION 162(m) OF THE INTERNAL REVENUE CODE

     Section 162(m) of the Code enacted as part of the Omnibus Budget
Reconciliation Act of 1993, provides that a publicly held corporation cannot
deduct compensation of a covered employee (the Chief Executive Officer and the
four other most highly compensated employees for the taxable year whose
compensation is required to be reported to stockholders under the Securities
Exchange Act of 1934, as amended) to the extent the compensation exceeds $1
million per tax year. There is a statutory exception to this limitation for
compensation based on the attainment of performance goals. Income derived from
stock options will qualify for this exception and thus be treated as
performance-based compensation if granted in accordance with the requirements
set forth in Section 162(m). The 1992 Stock Option Plan complies with those
requirements. However, because the 1992 Stock Option Plan is being amended to
increase the number of shares of Common Stock reserved for issuance under the
1992 Stock Option Plan, the Company is again required to obtain stockholder
approval for the amended plan in order for the options to continue to qualify as
performance-based compensation under Section 162(m).

                                       12
<PAGE>   15

NEW PLAN BENEFITS

     The Company cannot currently determine the number of shares subject to
options that may be granted in the future to executive officers and employees
under the Stock Option Plan. The actual benefits, if any, to the holders of
stock options issued under the Stock Option Plan are not determinable prior to
exercise as the value, if any, of such stock options to their holders is
represented by the difference between the market price of a share of the
Company's Common Stock on the date of exercise and the exercise price of a
holder's stock option. The following table presents certain information with
respect to stock awards granted under the 1992 Stock Option Plan for the fiscal
year ended December 31, 1999 to (i) each of the executive officers named in the
Summary Compensation Table, (ii) all executive officers as a group, (iii) all
non-executive officer directors as a group and (iv) all non-executive officer
employees as a group.

<TABLE>
<CAPTION>
                                                                                  NUMBER OF SHARES
                                                                                  SUBJECT TO STOCK
                                                              WEIGHTED AVERAGE    AWARDS GRANTED IN
                     NAME AND POSITION                         EXERCISE PRICE        FISCAL 1999
                     -----------------                        ----------------    -----------------
<S>                                                           <C>                 <C>
Thomas B. Okarma, Ph.D., M.D. ..............................       $11.07              335,000
  President and Chief Executive Officer
Ronald W. Eastman(1)........................................       $11.69               15,000
  Former President and Chief Executive Officer
David L. Greenwood..........................................       $11.57               95,000
  Chief Financial Officer, Senior Vice President of
  Corporate Development, Treasurer, and Secretary
Elaine R. Hamilton(2).......................................       $ 0.00                    0
  Vice President of Human Resources
Calvin B. Harley, Ph.D......................................       $11.83               45,000
  Chief Scientific Officer
Jane S. Lebkowski, Ph.D.....................................       $11.40               55,000
  Vice President of Cell and Gene Therapies
Richard L. Tolman, Ph.D. ...................................       $11.25               40,000
  Vice President of Drug Discovery
All Executive Officers as a group (9 persons)...............       $11.15              730,000
All Non-Executive Officer Directors as a Group (6
  persons)..................................................       $11.85              105,000
All Non-Executive Officer Employees as a Group (95
  persons)..................................................       $11.45              377,350
</TABLE>

- ---------------
(1) Mr. Eastman separated employment from the Company in July 1999. He remains a
    Director of the Company.

(2) Ms. Hamilton resigned from the Company in November 1999.

                                 REQUIRED VOTE

     Stockholders are requested in this Proposal 3 to approve the amendment to
the Stock Option Plan to increase the number of shares reserved for issuance
thereunder by 500,000 shares. The affirmative vote of the holders of a majority
of the shares present in person or represented by proxy and entitled to vote on
the proposal at the meeting will be required to approve the proposal.

        THE BOARD OF DIRECTORS RECOMMENDS A VOTE IN FAVOR OF PROPOSAL 3

                                   PROPOSAL 4

               RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS

     The Board of Directors has selected Ernst & Young LLP as the Company's
independent auditors for the fiscal year ending December 31, 2000 and has
further directed that management submit the selection of independent auditors
for ratification by the stockholders at the Annual Meeting. Ernst & Young LLP
has served as the Company's independent auditors since 1992. Representatives of
Ernst & Young LLP are

                                       13
<PAGE>   16

expected to be present at the Annual Meeting, will have an opportunity to make a
statement if they so desire and will be available to respond to appropriate
questions.

     Stockholder ratification of the selection of Ernst & Young LLP as the
Company's independent auditors is not required by the Company's By-laws or
otherwise. However, the Board is submitting the selection of Ernst & Young LLP
to the stockholders for ratification as a matter of good corporate practice. If
the stockholders fail to ratify the selection, the Audit Committee and the Board
will reconsider whether or not to retain that firm. Even if the selection is
ratified, the Audit Committee and the Board in their discretion may direct the
appointment of different independent auditors at any time during the year if
they determine that such a change would be in the best interests of the Company
and its stockholders.

                                 REQUIRED VOTE

     The affirmative vote of the holders of a majority of the shares present in
person or represented by proxy and entitled to vote on the proposal at the
meeting will be required to ratify the selection of Ernst & Young LLP.

        THE BOARD OF DIRECTORS RECOMMENDS A VOTE IN FAVOR OF PROPOSAL 4

         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

     The following table sets forth certain information regarding the beneficial
ownership of the Company's Common Stock as of March 15, 2000 by: (i) each
current director, (ii) each of the executive officers named in the Summary
Compensation Table; (iii) all executive officers and directors of the Company as
a group; and (v) all those known by the Company to be beneficial owners of more
than five percent of its Common Stock.

<TABLE>
<CAPTION>
                                                              BENEFICIAL OWNERSHIP(1)
                                                              -----------------------
                                                              NUMBER OF    PERCENT OF
                      BENEFICIAL OWNER                         SHARES        TOTAL
                      ----------------                        ---------    ----------
<S>                                                           <C>          <C>
Alexander E. Barkas, Ph.D.(2)...............................     85,128       *
Ronald W. Eastman(3)........................................    341,908       1.60%
Edward V. Fritzky(4)........................................     16,550       *
Thomas D. Kiley, Esq.(5)....................................     77,600       *
Gary L. Neil(6).............................................      3,300       *
Robert B. Stein, M.D., Ph.D.(7).............................     13,300       *
John P. Walker(8)...........................................     16,900       *
David L. Greenwood(9).......................................    176,237       *
Elaine R. Hamilton(10)......................................      2,492       *
Calvin B. Harley, Ph.D.(11).................................    163,440       *
Jane Lebkowski, Ph.D.(12)...................................     25,876       *
Thomas B. Okarma, Ph.D., M.D.(13)...........................    188,007       *
Richard L. Tolman, Ph.D.(14)................................     17,396       *
3i plc, 91 Waterloo Road,
  London, United Kingdom SE1 8XP............................  1,240,000       5.86%
All directors and executive officers as a group (13
  persons)..................................................  1,128,134       5.09%
</TABLE>

- ---------------
  *  Represents beneficial ownership of less than 1% of the Common Stock.

 (1) Beneficial ownership is determined in accordance with the rules of the
     Securities and Exchange Commission. In computing the number of shares
     beneficially owned by a person and the percentage of ownership of that
     person, shares of Common Stock subject to options held by that person that
     are currently exercisable or exercisable within 60 days of March 15, 2000
     are deemed outstanding. Such shares, however, are not deemed outstanding
     for the purpose of computing the percentage ownership of each other person.
     The persons named in this table have sole voting and investment power with
     respect

                                       14
<PAGE>   17

     to all shares of Common Stock shown as beneficially owned by them, subject
     to community property laws where applicable and except as indicated in the
     other footnotes to this table.

 (2) Includes 28,593 shares held directly by Alexander E. Barkas, 882 shares
     held by Lynda Wijcik, the spouse of Dr. Barkas, and 55,653 shares issuable
     upon the exercise of outstanding options held by Dr. Barkas exercisable
     within 60 days of March 15, 2000, at which date 55,653 shares were fully
     vested.

 (3) Includes an aggregate of 13,000 shares held by Patricia Eastman, the spouse
     of Ronald W. Eastman, as custodian for Mr. Eastman's three minor children.
     Also includes 65,941 shares held directly by Mr. Eastman and 262,967 shares
     issuable upon the exercise of outstanding options held by Mr. Eastman
     exercisable within 60 days of March 15, 2000, at which date 250,002 shares
     were fully vested. Mr. Eastman separated employment from the Company in
     July 1999. He remains a Director of the Company.

 (4) Represents 16,550 shares issuable upon the exercise of outstanding options
     held by Edward V. Fritzky exercisable within 60 days of March 15, 2000, at
     which date 16,550 shares were fully vested.

 (5) Includes 7,352 shares held directly by Thomas D. Kiley, 9,705 shares held
     by the Kiley Family Partnership and 14,302 shares held by the Thomas D.
     Kiley and Nancy L.M. Kiley Revocable Trust under Agreement dated August 7,
     1981. Also includes 46,241 shares issuable upon the exercise of outstanding
     options held by Mr. Kiley exercisable within 60 days of March 15, 2000, at
     which date 44,893 shares were fully vested.

 (6) Represents 3,300 shares issuable upon the exercise of outstanding options
     held by Gary L. Neil exercisable within 60 days of March 15, 2000, at which
     date 3,300 shares were fully vested.

 (7) Represents 13,300 shares issuable upon the exercise of outstanding options
     held by Robert B. Stein exercisable within 60 days of March 15, 2000, at
     which date 13,300 shares were fully vested.

 (8) Represents 16,900 shares issuable upon the exercise of outstanding options
     held by John P. Walker exercisable within 60 days of March 15, 2000, at
     which date 16,900 shares were fully vested.

 (9) Represents 176,237 shares issuable upon the exercise of outstanding options
     held by Mr. Greenwood exercisable within 60 days of March 15, 2000, at
     which date 166,897 shares were fully vested.

(10) Includes 2,492 shares held directly by Elaine R. Hamilton and no shares
     issuable upon the exercise of outstanding options held by Ms. Hamilton
     exercisable within 60 days of March 15, 2000. Ms. Hamilton resigned from
     the Company in November 1999.

(11) Includes 23,185 shares held by the Harley Family Trust and 140,255 shares
     issuable upon the exercise of outstanding options held by Dr. Harley
     exercisable within 60 days of March 15, 2000, at which date 136,479 shares
     were fully vested.

(12) Represents 25,876 shares issuable upon the exercise of outstanding options
     held by Jane S. Lebkowski exercisable within 60 days of March 15, 2000, at
     which date 25,876 shares were fully vested.

(13) Represents 188,007 shares issuable upon the exercise of outstanding options
     held by Thomas B. Okarma exercisable within 60 days of March 15, 2000, at
     which date 188,007 shares were fully vested.

(14) Represents 17,396 shares issuable upon the exercise of outstanding options
     held by Richard L. Tolman exercisable within 60 days of March 15, 2000, at
     which date 17,396 shares were fully vested.

                                       15
<PAGE>   18

                             EXECUTIVE COMPENSATION

COMPENSATION OF EXECUTIVE OFFICERS

     The following table provides certain information summarizing compensation
awarded or paid to, or earned by the Company's Chief Executive Officer and its
four other most highly compensated executive officers whose compensation was in
excess of $100,000 (the "Named Executive Officers") for services rendered in all
capacities to the Company for each of the last three fiscal years.

                           SUMMARY COMPENSATION TABLE

<TABLE>
<CAPTION>
                                                                                                    LONG-TERM
                                                                                                   COMPENSATION
                                                                                                      AWARDS
                                                              ANNUAL COMPENSATION                  ------------
                                                ------------------------------------------------    SECURITIES
                                                                                 OTHER ANNUAL       UNDERLYING
         NAME AND PRINCIPAL POSITION            YEAR   SALARY($)   BONUS($)   COMPENSATION(1)($)    OPTIONS(#)
         ---------------------------            ----   ---------   --------   ------------------   ------------
<S>                                             <C>    <C>         <C>        <C>                  <C>
Thomas B. Okarma Ph.D., M.D.(2)...............  1999   $277,590    $41,540         $    --           335,000
  President and Chief Executive Officer         1998    231,615     60,180              --           370,000
                                                1997     16,250         --              --           150,000
Ronald W. Eastman(3)..........................  1999    310,199         --              --            15,000
  Former President and Chief Executive Officer  1998    295,000     78,180              --           325,297
                                                1997    257,300     46,300          30,000           230,000
David L. Greenwood............................  1999    240,000     35,900          12,000            95,000
  Chief Financial Officer, Senior Vice          1998    205,000     62,280          30,000           241,341
  President of Corporate Development,
  Treasurer,                                    1997    198,800     38,800          64,370           165,000
  and Secretary
Elaine R. Hamilton(4).........................  1999    126,550         --              --                --
  Vice President of Human Resources             1998     87,500     19,250              --            90,000
Calvin B. Harley, Ph.D........................  1999    239,200     35,880              --            45,000
  Chief Scientific Officer                      1998    223,750     58,190              --           194,805
                                                1997    180,600     41,500          18,000           125,000
Jane S. Lebkowski, Ph.D.(5)...................  1999    173,333     25,930              --            55,000
  Vice President of Cell and Gene Therapies     1998    109,128     36,740              --            80,000
Richard L. Tolman, Ph.D.(6)...................  1999    181,667     27,170          79,891            40,000
  Vice President of Drug Discovery              1998     15,000     25,000           2,190            35,000
</TABLE>

- ---------------
(1) Other annual compensation consists of monthly housing allowances and
    relocation allowances.

(2) Dr. Okarma joined the Company in December 1997. He was promoted to President
    and Chief Executive Officer in July 1999.

(3) Mr. Eastman separated employment from the Company in July 1999. Mr. Eastman
    remains a Director of the Company.

(4) Ms. Hamilton resigned from the Company in November 1999.

(5) Dr. Lebkowski joined the Company in April 1998. She was promoted to Vice
    President of Cell and Gene Therapies in August 1999.

(6) Dr. Tolman joined the Company in December 1998. He was promoted to Vice
    President of Drug Discovery in August 1999.

                                       16
<PAGE>   19

STOCK OPTION GRANTS IN FISCAL YEAR 1999

     The following table provides certain information regarding options granted
to the Chief Executive Officer and the Named Executive Officers during the year
ended December 31, 1999. No stock appreciation rights were granted during the
year.

<TABLE>
<CAPTION>
                                                       INDIVIDUAL GRANTS                           POTENTIAL REALIZABLE
                                  ------------------------------------------------------------       VALUE AT ASSUMED
                                                       PERCENT OF                                     ANNUAL RATES OF
                                  NUMBER OF SHARES   TOTAL OPTIONS                               STOCK PRICE APPRECIATION
                                     UNDERLYING        GRANTED TO     EXERCISE OR                   FOR OPTION TERM(4)
                                      OPTIONS         EMPLOYEES IN    BASE PRICE    EXPIRATION   -------------------------
              NAME                 GRANTED(#)(1)     FISCAL YEAR(2)    ($/SH)(3)       DATE         5%($)        10%($)
              ----                ----------------   --------------   -----------   ----------   -----------   -----------
<S>                               <C>                <C>              <C>           <C>          <C>           <C>
Thomas B. Okarma, Ph.D., M.D....       35,000              3.2%         $11.69        5/17/09    $  257,312    $  652,079
                                      300,000             27.1           11.00        7/22/09     2,075,352     5,259,350
Ronald W. Eastman(5)............       15,000              1.4           11.69        5/18/09       110,277       276,463
David L. Greenwood..............       35,000              3.2           11.69        5/18/09       257,312       652,080
                                       20,000              1.8           10.50        10/1/09       132,068       334,686
                                       40,000              3.6           12.00       12/17/09       301,869       764,996
Elaine R. Hamilton(6)...........           --               --              --             --            --            --
Calvin B. Harley, Ph.D..........       12,500              1.1           11.69        5/18/09        91,897       232,886
                                       12,500              1.1           11.69        5/18/09        91,897       232,886
                                       20,000              1.8           12.00       12/17/09       150,935       382,498
Jane S. Lebkowski, Ph.D.........       10,000              0.9           11.69        5/18/09        73,518       186,308
                                       20,000              1.8           10.50        10/1/09       132,068       334,686
                                       25,000              2.3           12.00       12/17/09       188,668       478,123
Richard L. Tolman, Ph.D.........       20,000              1.8           10.50        10/1/09       132,068       334,686
                                       20,000              1.8           12.00       12/17/09       150,935       382,498
</TABLE>

- ---------------
(1) Each of these stock options, which were granted under the 1992 Stock Option
    Plan, are exercisable in a series of installments measured from the vesting
    commencement date generally over 48 months, provided that each Named
    Executive Officer continues to provide services to the Company. In the event
    of certain transactions involving changes in control of the Company, the
    options will vest in full. The maximum term of each option grant is ten
    years from the date of grant.

(2) Based on an aggregate of 1,107,350 options granted by the Company in the
    year ended December 31, 1999 to all employees of the Company, including the
    Named Executive Officers.

(3) Exercise price is the closing sales price of the Common Stock underlying the
    stock option on the grant date as reported on the Nasdaq National Market.

(4) The 5% and 10% assumed annual rates of compounded stock price appreciation
    are mandated by the Securities and Exchange Commission. There is no
    assurance provided to any executive officer or any other holder of the
    Company's securities that the actual stock price appreciation over the ten
    year option term will be at the assumed 5% and 10% levels or at any other
    defined level. Unless the market price of the Common Stock appreciates over
    the option term, no value will be realized from the option grants made to
    the executive officers.

(5) Mr. Eastman separated employment from the Company in July 1999. He remains a
    Director of the Company.

(6) Ms. Hamilton resigned from the Company in November 1999.

                                       17
<PAGE>   20

AGGREGATE OPTION EXERCISES IN FISCAL YEAR 1999 AND FISCAL YEAR-END OPTION VALUES

     The following table sets forth information with respect to options
exercised during the year ended December 31, 1999 by the Chief Executive Officer
and Named Executive Officers and unexercised options held as of the end of such
fiscal year by such persons:

<TABLE>
<CAPTION>
                                                                          NUMBER OF
                                                                          SECURITIES
                                                                          UNDERLYING         VALUE OF UNEXERCISED
                                                                         UNEXERCISED         IN-THE-MONEY OPTIONS
                                                                      OPTIONS AT FISCAL        AT FISCAL YEAR-
                                         SHARES                         YEAR-END(2)(#)           END($)(2)(3)
                                       ACQUIRED ON       VALUE        ------------------   ------------------------
                NAME                   EXERCISE(#)   REALIZED(1)($)   VESTED    UNVESTED     VESTED      UNVESTED
                ----                   -----------   --------------   -------   --------   ----------   -----------
<S>                                    <C>           <C>              <C>       <C>        <C>          <C>
Thomas B. Okarma, Ph.D., M.D.........         0         $      0      138,527   481,473    $  902,732   $1,873,088
Ronald W. Eastman(4).................    65,000          697,393      312,425   216,255     3,009,312    1,689,946
David L. Greenwood...................    30,000          414,833      130,235   242,117     1,037,396    1,367,786
Elaine R. Hamilton(5)................         0                0       15,251         0       121,154            0
Calvin B. Harley, Ph.D...............         0                0      113,387   162,901       962,875    1,017,938
Jane S. Lebkowski, Ph.D..............         0                0       17,500    82,500       121,091      302,629
Richard L. Tolman, Ph.D..............         0                0       10,000    65,000        17,969       98,281
</TABLE>

- ---------------
(1) Fair market value of the Company's Common Stock on the date of exercise
    (based on the closing sales price reported on the Nasdaq National Market or
    the actual sales price if the shares were sold by the optionee on the same
    date) less the exercise price.

(2) These stock options, which were granted under the 1992 Stock Option Plan,
    are exercisable in a series of installments measured from the vesting
    commencement date generally over 48 months, provided that each Named
    Executive Officer continues to provide services to the Company. In the event
    of certain transactions involving changes in control of the Company, the
    options will vest in full. The maximum term of each option grant is ten
    years from the date of grant.

(3) Based on the closing sales price of the Common Stock as of December 31,
    1999, quoted on the Nasdaq National Market ($12.63 per share), minus the per
    share exercise price, multiplied by the number of shares underlying the
    option.

(4) Mr. Eastman separated employment from the Company in July 1999. He remains a
    Director of the Company.

(5) Ms. Hamilton resigned from the Company in November 1999.

EMPLOYMENT CONTRACTS, TERMINATION OF EMPLOYMENT ARRANGEMENTS AND CHANGE OF
CONTROL AGREEMENTS

     The Company does not have any employment agreements with any of the Named
Executive Officers.

     In the event of a change in control of the Company, the 1992 Stock Option
Plan provides that each outstanding option will accelerate so that each option
will be fully exercisable for all of the shares subject to such option
immediately prior to the effective date of the transaction. In addition, upon
the occurrence of such transaction, the Stock Option Plan provides that all of
the outstanding repurchase rights of the Company with respect to shares of
Common Stock acquired upon exercise of options granted under the 1992 Stock
Option Plan will terminate.

                                       18
<PAGE>   21

                        COMPENSATION COMMITTEE REPORT(1)

     In 1999, the Compensation Committee of the Board of Directors (the
"Committee") consisted of Dr. Barkas and Mr. Walker, neither of whom is an
officer or an employee of the Company. The Committee is responsible for making
recommendations and taking actions concerning salaries and incentive
compensation of officers and employees of the Company, including the award of
stock options under the Company's stock option plan. In particular, the
Committee evaluates the performance of management and determines the
compensation of the Chief Executive Officer and other executive officers on an
annual basis. Executive officers who are also directors are not present during
the discussion of their compensation.

PHILOSOPHY

     The Company's executive compensation philosophy is to attract and retain
executive officers capable of leading the Company to fulfillment of its business
objectives by offering competitive compensation opportunities that reward
individual contributions as well as corporate performance. Accordingly, the
Company's executive compensation policies include:

     - competitive pay practices, taking into account the pay practices of life
       science and pharmaceutical companies with which the Company competes for
       talented executives, including those companies listed in the
       Nasdaq-Pharmaceutical Index;

     - annual incentive programs which are designed to encourage executives to
       focus on the achievement of specific short-term corporate goals as well
       as longer-term strategic objectives;

     - equity-based incentives designed to motivate executives over the long
       term, to align the interests of management and stockholders and to ensure
       that management is appropriately rewarded for achievements which benefit
       the Company's stockholders.

     In the biopharmaceutical industry, many traditional measures of corporate
performance, such as earnings per share or sales growth, may not readily apply
in reviewing performance of executives. Because of the Company's current stage
of development, the Committee evaluates other indications of performance, such
as progress of the Company's research and development programs and corporate
development activities, as well as the Company's success in securing capital
sufficient to enable the Company to continue research and development
activities. These considerations necessarily involve an assessment by the
Committee of individual and corporate performance. In addition, total
compensation paid by the Company to its executive officers is designed to be
comparable to compensation packages paid to the management of other companies of
comparable size in the biopharmaceutical industry. Toward that end, the
Committee may review both independent survey data as well as data gathered
internally.

EXECUTIVE OFFICER COMPENSATION

     Compensation for each of the Company's executive officers, including the
Chief Executive Officer, generally consists of three elements: a cash salary, a
cash incentive bonus and stock option grants with exercise prices generally set
at the fair market value at the time of the grant. Base salaries are determined
at the beginning of the fiscal year, whereas cash bonuses are awarded on a
discretionary basis, usually following the Company's fiscal year-end, and are
based on the achievement of corporate and individual goals set by the Board and
the Company's Chief Executive Officer at the beginning of the year, as well as
the financial condition and prospects for the Company.

     The Company has used the grant of options under its 1992 Stock Option Plan
to underscore the common interests of stockholders and management. Options
granted to executive officers are intended to provide a continuing financial
incentive to maximize long-term value to stockholders and to make each
executive's total
- ---------------

(1) This Section is not "soliciting material," is not deemed "filed" with the
    SEC and is not to be incorporated by reference in any filing of the Company
    under the Securities Act of 1933, as amended (the "Securities Act"), or the
    Exchange Act, whether made before or after the date hereof and irrespective
    of any general incorporation language in any such filing.

                                       19
<PAGE>   22

compensation opportunity competitive. In addition, because stock options
generally become exercisable over a period of several years, options encourage
executives to remain in the long-term employ of the Company. In determining the
size of an option to be granted to an executive officer, the Committee takes
into account an officer's position and level of responsibility within the
Company, the officer's existing stock and option holdings, and the potential
reward to the officer if the stock price appreciates in the public market.

     In December 1999, the Committee met to evaluate the Company and individual
performance against the goals for 1999. These goals included the progressive
development of the Company's scientific programs; completion of the Roslin
Bio-Med acquisition and integration of the nuclear transfer technology with the
Company's existing technology platforms; and the obtainment of additional
funding for the Company's operations. The Committee determined that the Company
successfully achieved many of its objectives. As a result, based on corporate
performance, the Committee recommended that individual executive officers
receive cash bonuses, depending on the Committee's assessment of individual
performance, of up to 15% of such officer's eligible 1999 compensation.

CHIEF EXECUTIVE OFFICER COMPENSATION

     At the end of 1999, the Committee did not increase the salary of Dr. Okarma
as a result of his recent promotion to President and Chief Executive Officer in
July 1999. Dr. Okarma's salary was also reviewed in comparison to compensation
paid to chief executive officers of other companies in the biopharmaceutical
industry. In making its determination with respect to the bonus to be awarded to
Dr. Okarma for 1999, the Committee's assessment was that Dr. Okarma had
significant impact in achieving company performance objectives for 1999.

COMPLIANCE WITH INTERNAL REVENUE CODE SECTION 162(m)

     Section 162(m) of the U.S. Internal Revenue Code limits the tax
deductibility by a corporation of compensation in excess of $1 million paid to
any of its five most highly compensated executive officers. However,
compensation which qualifies as "performance-based" is excluded from the $1
million limit if, among other requirements, the compensation is payable only
upon attainment of pre-established, objective performance goals under a plan
approved by stockholders.

     The Compensation Committee does not presently expect total cash
compensation payable for salaries to exceed the $1 million limit for any
individual executive. Having considered the requirements of Section 162(m), the
Compensation Committee believes that stock option grants to date meet the
requirement that such grants be "performance based" and are, therefore, exempt
from the limitations on deductibility. The Compensation Committee will continue
to monitor the compensation levels potentially payable under the Company's cash
compensation programs, but intends to retain the flexibility necessary to
provide total cash compensation in line with competitive practice, the Company's
compensation philosophy, and the Company's best interests.

               Alexander E. Barkas, Ph.D.          John P. Walker

                                       20
<PAGE>   23

                              PERFORMANCE GRAPH(1)

     The following graph compares total stockholder returns of the Company since
its initial public offering of Common Stock on July 30, 1996 to two indices: the
Nasdaq CRSP Total Return Index for the Nasdaq Stock Market-U.S. Companies (the
"Nasdaq-US") and the Nasdaq Pharmaceutical Index (the "Nasdaq-Pharmaceutical").
The total return for the Company's stock and for each index assumes the
reinvestment of dividends, although dividends have never been declared on the
Company's stock, and is based on the returns of the component companies weighted
according to their capitalizations as of the end of each monthly period. The
Nasdaq-US tracks the aggregate price performance of equity securities of U.S.
companies traded on the Nasdaq National Market (the "NNM"). The
Nasdaq-Pharmaceutical tracks the aggregate price performance of equity
securities of pharmaceutical companies traded on the NNM. The Company's Common
Stock is traded on the NNM and is a component of both the Nasdaq-US and the
Nasdaq-Pharmaceutical.

           COMPARISON OF CUMULATIVE TOTAL RETURN ON INVESTMENT SINCE
           THE COMPANY'S INITIAL PUBLIC OFFERING ON JULY 30, 1996(2)
PERFORMANCE GRAPH

<TABLE>
<CAPTION>
                                                           US                    PHARMACEUTICAL                   GERON
                                                           --                    --------------                   -----
<S>                                             <C>                         <C>                         <C>
7/31/96                                                    100                         100                         100
                                                           106                         107                          89
9/30/96                                                    114                         115                          90
                                                           112                         110                          98
11/29/96                                                   119                         108                         102
                                                           119                         111                         171
1/31/97                                                    128                         121                         168
                                                           121                         121                         139
3/31/97                                                    113                         106                         126
                                                           116                          99                         127
5/31/97                                                    130                         114                         115
                                                           133                         114                          97
7/31/97                                                    148                         117                          87
                                                           147                         116                         124
9/30/97                                                    156                         128                         140
                                                           148                         121                         135
11/30/97                                                   149                         118                         110
                                                           146                         115                         106
1/31/98                                                    151                         114                         165
                                                           165                         118                         142
3/31/98                                                    171                         126                         160
                                                           174                         123                         141
5/31/98                                                    164                         119                         144
                                                           176                         117                         121
7/31/98                                                    174                         118                          98
                                                           139                          90                          54
9/30/98                                                    159                         110                          79
                                                           166                         118                          80
11/30/98                                                   182                         124                         145
                                                           206                         146                         140
1/31/99                                                    236                         160                         152
                                                           215                         150                         136
3/31/99                                                    230                         160                         129
                                                           237                         148                         152
5/31/99                                                    231                         157                         155
                                                           252                         163                         135
7/31/99                                                    248                         182                         158
                                                           258                         198                         140
9/30/99                                                    258                         187                         135
                                                           277                         189                         123
11/30/99                                                   306                         213                         139
                                                           372                         273                         163
</TABLE>

- ---------------

(1) This Section is not "soliciting material," is not deemed "filed" with the
    SEC and is not to be incorporated by reference in any filing of the Company
    under the Securities Act of 1933, as amended (the "Securities Act"), or the
    Exchange Act, whether made before or after the date hereof and irrespective
    of any general incorporation language in any such filing.

(2) Shows the cumulative total return on investment assuming an investment of
    $100 in each of the Company, the Nasdaq-US and the Nasdaq-Pharmaceutical on
    July 30, 1996. The cumulative total return on the Company's stock has been
    computed based on an initial price of $8.00 per share, the price at which
    the Company's shares were sold in its initial public offering on July 30,
    1996.

                                       21
<PAGE>   24

                              CERTAIN TRANSACTIONS

     In December 1993, the Company provided an interest-free loan to Calvin B.
Harley, Chief Scientific Officer, in the principal amount of $150,000, due
December 1, 1996, pursuant to a note secured by a second deed of trust to Dr.
Harley's residence in Palo Alto, California. On December 1, 1996, the Company
agreed to extend the due date of the interest-free loan to December 31, 1998. In
February 1999, the Company agreed to restructure the loan and extend the due
date to December 31, 2002. The loan will be paid through annual installments of
$37,500. As of December 31, 1999, the outstanding balance on this loan was
$112,500.

     In July 1999, Ronald W. Eastman separated employment from the Company in
July 1999. In conjunction with his separation agreement, the Company agreed to
extend the vesting schedule of his existing options for a period of one year. In
addition, the Company continued Mr. Eastman's salary and benefits until he
became fully employed at another company. Mr. Eastman remains a Director of the
Company.

     In August 1999, the Company provided an interest-free loan to David J.
Earp, Vice President of Intellectual Property, in the principal amount of
$100,000 due in two installments: one-half of the principal balance in August
2002 and the remainder in August 2003. As of December 31, 1999, the outstanding
balance on this loan was $100,000.

     In addition, the Company has entered into consulting arrangements with
Messrs. Kiley and Walker. See "Compensation of Directors".

     The Company has entered into indemnity agreements with all of its officers
and directors which provide, among other things, that the Company will indemnify
such officer or director, under the circumstances and to the extent provided for
therein, for expenses, damages, judgments, fines, settlements he or she may be
required to pay in actions or proceedings which he or she is or may be made a
party by reason for his position as a director, officer or other agent of the
Company, and otherwise to the full extent permitted under Delaware law and the
Company's By-laws.

            SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

     Section 16(a) of the Exchange Act requires the Company's directors and
executive officers, and persons who own more than 10% of a registered class of
the Company's equity securities (collectively "Reporting Persons"), to file with
the SEC initial reports of ownership and reports of changes in ownership of
Common Stock and other equity securities of the Company. Reporting persons are
required by SEC regulations to furnish the Company with copies of all Section
16(a) forms they file.

     To the Company's knowledge, based solely on a review of the copies of such
reports furnished to the Company and written representations that no other
reports were required, the Company believes that during fiscal year ended
December 31, 1999, all Reporting Persons complied with the applicable filing
requirement, with the following exceptions: a Form 3 was filed late in
connection with the appointment of Amy L. Collins as Vice President of
Intellectual Property in March 1999 and in May 1999 Form 4s were filed late in
connection with options granted to directors in connection with their
re-election to the Board.

                                       22
<PAGE>   25

                                 OTHER MATTERS

     The Board of Directors knows of no other matters that will be presented for
consideration at the Annual Meeting. If any other matters are properly brought
before the meeting, it is the intention of the persons named in the accompanying
proxy to vote on such matters in accordance with their best judgment.

                                          By Order of the Board of Directors

                                          /s/ David L. Greenwood
                                          DAVID L. GREENWOOD
                                          Secretary
April   , 2000

                                       23
<PAGE>   26

                                  [GERON LOGO]
<PAGE>   27

                                                                      APPENDIX 1

                            CERTIFICATE OF AMENDMENT

                                       OF

                     RESTATED CERTIFICATE OF INCORPORATION

                                       OF

                               GERON CORPORATION

     Thomas B. Okarma and David L. Greenwood hereby certify that:

     FIRST: They are the duly elected and acting President and Secretary of
Geron Corporation, a Delaware corporation.

     SECOND: The name of this Corporation is Geron Corporation (the
"Corporation").

     THIRD: The date on which the Restated Certificate of Incorporation as filed
with the Secretary of State of the State of Delaware (the "Secretary of State")
is March 24, 1998. The date on which the Certificate of Designation was filed
with the Secretary of State is March 27, 1998. The date on which the Certificate
of Amendment of Restated Certificate of Incorporation was filed with the
Secretary of State of the State of Delaware is December 14, 1999.

     FOURTH: The amendment to the Corporation's Restated Certificate of
Incorporation set forth below was duly adopted by the Board of Directors of the
Corporation, and approved by the Stockholders in accordance with the provisions
of Section 242 of the General Corporation Law of the State of Delaware.

     FIFTH: Article IV, Paragraph (A) of the Corporation's Restated Certificate
of Incorporation is amended to read in its entirety as follows:

          (A) Class of Stock. The Corporation is authorized to issue two classes
     of stock to be designated, respectively, "Common Stock" and "Preferred
     Stock." The total number of shares which the Corporation is authorized to
     issue is Fifty-Three Million (53,000,000) shares. Fifty Million
     (50,000,000) shares shall be Common Stock, par value $0.001 per share and
     Three Million (3,000,000) shares shall be Preferred Stock, par value $0.001
     per share.

     IN WITNESS WHEREOF, the undersigned have signed this Certificate of
Amendment of Restated Certificate of Incorporation this                day of
May, 2000 and hereby affirm and acknowledge under the penalty of perjury that
the filing of this Certificate of Amendment of Restated Certificate of
Incorporation of Geron Corporation is the act and deed of Geron Corporation.

                                          Geron Corporation

                                          By:

                                            ------------------------------------
                                                      Thomas B. Okarma
                                                         President

Attest:

By:

    ----------------------------------
            David L. Greenwood
                Secretary

                                       A-1
<PAGE>   28

          THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

                               GERON CORPORATION
                      2000 ANNUAL MEETING OF STOCKHOLDERS

    The undersigned stockholder of Geron Corporation, a Delaware corporation,
(the "Company") hereby acknowledges receipt of the Notice of Annual Meeting of
Stockholders and Proxy Statement, each dated April   , 2000, and hereby appoints
Thomas B. Okarma and David L. Greenwood, or either of them, as proxies and
attorneys-in-fact with full power to each of substitution, on behalf and in the
name of the undersigned to represent the undersigned at the 2000 Annual Meeting
of Stockholders of Geron Corporation to be held on May 26, 2000, at 9:00 a.m.,
at the headquarters of the Company at 230 Constitution Drive, Menlo Park,
California 94025, and at any adjournment(s) or postponement(s) thereof, and to
vote all shares of Common Stock that the undersigned would be entitled to vote
if then and there personally present, on the matters set forth on the reverse
side, and in their discretion, upon such other matter or matters that may
properly come before the meeting and any adjournment(s) thereof.

    This proxy will be voted as directed or, if no contrary direction is
indicated, will be voted as follows: (1) for the election of three Class I
Directors to serve for a term of three years; (2) for the approval and
ratification of an amendment to the Company's Restated Certificate of
Incorporation to increase the number of authorized shares of Common Stock from
35,000,000 shares to 50,000,000 shares; (3) for the approval and ratification of
an amendment to the Company's 1992 Stock Option Plan to increase the number of
shares of Common Stock reserved for issuance thereunder by 500,000 shares; (4)
for ratification of the selection of Ernst & Young LLP as independent auditors
and as said proxies deem advisable on such other matters as may come before the
meeting.

                   CONTINUED AND TO BE SIGNED ON REVERSE SIDE
<PAGE>   29

[X] Please mark your votes as in this example.

1. Election of Class I Directors    [ ] FOR all nominees (except as
   indicated)    [ ] WITHHOLD authority to vote for all nominees

   Nominees: Gary L. Neil, Thomas B. Okarma and John P. Walker

   If you wish to withhold authority to vote for any individual nominee, strike
   a line through that individual's name.

2. To approve and ratify an amendment to the Company's Restated Certificate of
   Incorporation to increase the number of authorized shares of Common Stock
   from 35,000,000 shares to 50,000,000 shares.    [ ] FOR  [ ] AGAINST  [
   ] ABSTAIN

3. To approve and ratify an amendment to the Company's 1992 Stock Option Plan to
   increase the number of shares of Common Stock reserved for issuance
   thereunder by 500,000 shares.    [ ] FOR  [ ] AGAINST  [ ] ABSTAIN

4. To ratify the selection of Ernst & Young LLP as the Company's independent
   auditors for the fiscal year ending December 31, 2000.
   [ ] FOR  [ ] AGAINST  [ ] ABSTAIN
                                              Note: This Proxy should be marked,
                                              dated, signed by the
                                              stockholder(s) exactly as his or
                                              her name appears hereon, and
                                              returned in the enclosed envelope.

                                              SIGNATURE(S)
                                                    ----------------------------

                                              DATE
                                                --------------------------------

                                              Please sign exactly as name(s)
                                              appears hereon. When shares are
                                              held by joint tenants, both should
                                              sign. When signing as attorney,
                                              executor, administrator, trustee,
                                              or guardian, please give full
                                              title as such. If a corporation,
                                              please sign in full corporate name
                                              by President or other authorized
                                              officer. If a partnership, please
                                              sign in partnership name by
                                              authorized person.

  PLEASE MARK, SIGN, DATE AND RETURN THE PROXY CARD IN THE ENCLOSED ENVELOPE.


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