CANTAB PHARMACEUTICALS PLC /ADR/
SC 13G/A, 2000-02-14
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                                  ____________

                                 SCHEDULE 13G/A

                    Under the Securities Exchange Act of 1934

                                (Amendment No. 1)

                           Cantab Pharmaceuticals plc.
                                (Name of issuer)

                                 Ordinary Shares
                         (Title of class of securities)

                                    138084108
                                 (CUSIP number)

                                December 31, 1999
             (Date of Event which requires filing of this Statement)

                 Check the appropriate box to designate the rule
                   pursuant to which this schedule is filed:

                               | | Rule 13d-1 (b)
                               |X| Rule 13d-1 (c)
                               | | Rule 13d-1 (d)


<PAGE>
                                       13G
CUSIP No. 138084108                                           Page 2 of 10 Pages


 ---- -------------------------------------------------------------------------
| 1  |   NAME OF REPORTING PERSON                                              |
|    |   S.S. OR I.R.S.IDENTIFICATION NO. OF ABOVE PERSON                      |
|    |                                                                         |
|    |   Deutsche Bank A.G.                                                    |
 ---- -------------------------------------------------------------------------
| 2  |   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) |_| |
|    |                                                                 (b) |_| |
 ---- -------------------------------------------------------------------------
| 3  |   SEC USE ONLY                                                          |
|    |                                                                         |
 ---- -------------------------------------------------------------------------
| 4  |   CITIZENSHIP OR PLACE OF ORGANIZATION                                  |
|    |                                                                         |
|    |   Federal Republic of Germany                                           |
- -------------------------------------------------------------------------------
| NUMBER       | 5  |   SOLE VOTING POWER                                      |
| OF           |    |   0                                                      |
 ------------------------------------------------------------------------------
| SHARES       |    |                                                          |
| BENEFICIALLY | 6  |   SHARED VOTING POWER                                    |
| OWNED        |    |   2,407,127                                              |
 ------------------------------------------------------------------------------
| BY           |    |                                                          |
| EACH         | 7  |   SOLE DISPOSITIVE POWER                                 |
| REPORTING    |    |   0                                                      |
 ------------------------------------------------------------------------------
| PERSON       |    |                                                          |
| WITH         | 8  |   SHARED DISPOSITIVE POWER                               |
|              |    |   2,407,127                                              |
 ------------------------------------------------------------------------------
| 9  | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON            |
|    |                                                                         |
|    | 2,407,127*                                                              |
 ---- -- ----------------------------------------------------------------------
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES                   |
|    | CERTAIN SHARES                                                |_|       |
 ---- -------------------------------------------------------------------------
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                       |
|    |                                                                         |
|    | 5.5%**                                                                  |
 ---- -------------------------------------------------------------------------
| 12 | TYPE OF REPORTING PERSON                                                |
|    |                                                                         |
|    | HC, BK, CO                                                              |
 ---- -------------------------------------------------------------------------




*    Included in this  figure are the  securities  reported  by  Deutsche  Asset
     Management  Group  Limited and  Deutsche  Asset  Management  Limited on the
     following cover pages.

**   Included in this percentage are the  percentages of securities  reported by
     Deutsche  Asset  Management  Group  Limited and Deutsche  Asset  Management
     Limited on the following cover pages.



<PAGE>


                                      13G
CUSIP No. 138084108                                           Page 3 of 10 Pages



 ---- -------------------------------------------------------------------------
| 1  |   NAME OF REPORTING PERSON                                              |
|    |   S.S. OR I.R.S.IDENTIFICATION NO. OF ABOVE PERSON                      |
|    |                                                                         |
|    |   Deutsche Asset Management Group Limited (f/k/a Morgan Grenfell Asset  |
|    |   Management Limited)                                                   |
 ---- -------------------------------------------------------------------------
| 2  |   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) |_| |
|    |                                                                 (b) |_| |
 ---- -------------------------------------------------------------------------
| 3  |   SEC USE ONLY                                                          |
|    |                                                                         |
 ---- -------------------------------------------------------------------------
| 4  |   CITIZENSHIP OR PLACE OF ORGANIZATION                                  |
|    |                                                                         |
|    |   England and Wales                                                     |
- -------------------------------------------------------------------------------
| NUMBER       | 5  |   SOLE VOTING POWER                                      |
| OF           |    |   0                                                      |
 ------------------------------------------------------------------------------
| SHARES       |    |                                                          |
| BENEFICIALLY | 6  |   SHARED VOTING POWER                                    |
| OWNED        |    |   2,407,127                                              |
 ------------------------------------------------------------------------------
| BY           |    |                                                          |
| EACH         | 7  |   SOLE DISPOSITIVE POWER                                 |
| REPORTING    |    |   0                                                      |
 ------------------------------------------------------------------------------
| PERSON       |    |                                                          |
| WITH         | 8  |   SHARED DISPOSITIVE POWER                               |
|              |    |   2,407,127                                              |
 ------------------------------------------------------------------------------
| 9  | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON            |
|    |                                                                         |
|    | 2,407,127*                                                              |
 ---- -- ----------------------------------------------------------------------
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES                   |
|    | CERTAIN SHARES                                                      |_| |
 ---- -------------------------------------------------------------------------
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                       |
|    |                                                                         |
|    | 5.5%                                                                    |
 ---- -------------------------------------------------------------------------
| 12 | TYPE OF REPORTING PERSON                                                |
|    |                                                                         |
|    | HC                                                                      |
 ---- -------------------------------------------------------------------------


*    Included in this  figure are the  securities  reported  by  Deutsche  Asset
     Management Limited on the following cover page.

**   Included in this  percentage is the  percentage  of securities  reported by
     Deutsche Asset Management Limited on the following cover page.



<PAGE>
                                      13G
CUSIP No. 138084108                                           Page 4 of 10 Pages



 ---- -------------------------------------------------------------------------
| 1  |   NAME OF REPORTING PERSON                                              |
|    |   S.S. OR I.R.S.IDENTIFICATION NO. OF ABOVE PERSON                      |
|    |                                                                         |
|    |   (Deutsche Asset Management Limited f/k/a                              |
|    |   Morgan Grenfell Investment Management Limited)                        |
 ---- -------------------------------------------------------------------------
| 2  |   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) |_| |
|    |                                                                 (b) |_| |
 ---- -------------------------------------------------------------------------
| 3  |   SEC USE ONLY                                                          |
|    |                                                                         |
 ---- -------------------------------------------------------------------------
| 4  |   CITIZENSHIP OR PLACE OF ORGANIZATION                                  |
|    |                                                                         |
|    |   England and Wales                                                     |
 ------------------------------------------------------------------------------
| NUMBER       | 5  |   SOLE VOTING POWER                                      |
| OF           |    |   0                                                      |
 ------------------------------------------------------------------------------
| SHARES       |    |                                                          |
| BENEFICIALLY | 6  |   SHARED VOTING POWER                                    |
| OWNED        |    |   2,407,127                                              |
 ------------------------------------------------------------------------------
| BY           |    |                                                          |
| EACH         | 7  |   SOLE DISPOSITIVE POWER                                 |
| REPORTING    |    |   0                                                      |
 ------------------------------------------------------------------------------
| PERSON       |    |                                                          |
| WITH         | 8  |   SHARED DISPOSITIVE POWER                               |
|              |    |   2,407,127                                              |
 ------------------------------------------------------------------------------
| 9  | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON            |
|    |                                                                         |
|    | 2,407,127                                                               |
 ---- -- ----------------------------------------------------------------------
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES                   |
|    | CERTAIN SHARES                                                      |_| |
 ---- -------------------------------------------------------------------------
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                       |
|    |                                                                         |
|    | 5.5%                                                                   |
 ---- -------------------------------------------------------------------------
| 12 | TYPE OF REPORTING PERSON                                                |
|    |                                                                         |
|    | IA                                                                      |
 ---- -------------------------------------------------------------------------




<PAGE>
Item 1(a).          Name of Issuer:

                    Cantab Pharmaceuticals plc. (the "Issuer")

Item 1(b).          Address of Issuer's Principal Executive Offices:

                    The address of the Issuer's  principal  executive offices is
                    184 Cambridge Science Park, Milton Road,  Cambridge CB4 4GN,
                    United Kingdom.

Item 2(a).          Name of Person Filing:

                    This  statement  is  filed on  behalf  of  Deutsche  Bank AG
                    ("DBAG"),  Deutsche Asset  Management Group Limited ("DAMG")
                    and Deutsche Asset Management  Limited,  London ("DAML" and,
                    together with DBAG and DAMG, the "Reporting Persons").  This
                    Schedule 13G/A is being filed pursuant to Rule 13d-2(b).

Item 2(b).          Address of Principal Business Office or, if none, Residence:

                    The principal place of business of DBAG is Taunusanlage  12,
                    D-60325, Frankfurt am Main, Federal Republic of Germany.

                    The  principal  place  of  business  of DAMG is 20  Finsbury
                    Circus, London, EC2M 1NB, England.

                    The  principal  place  of  business  of DAML is 20  Finsbury
                    Circus, London, EC2M INB, England.

Item 2(c).          Citizenship:

                    The  citizenship  of each of the  Reporting  Persons  is set
                    forth on the applicable cover page.

Item 2(d).          Title of Class of Securities:

                    The title of the securities is ordinary  shares,  which also
                    includes  securities held in the form of American Depository
                    Receipts (the "Ordinary Shares").

Item 2(e).          CUSIP Number:

                    The CUSIP number of the Ordinary Shares is set forth on each
                    cover page.

Item 3              If this  statement is filed pursuant to Rules  13d-1(b),  or
                    13d-2(b) or (c), check whether the person filing is a:

                    (a) |_| Broker or dealer  registered under section 15 of the
                            Act;

                    (b) |_| Bank as defined in section 3(a)(6) of the Act;

                    (c) |_| Insurance  Company as defined in section 3(a)(19) of
                            the Act;

                    (d) |_| Investment Company registered under section 8 of the
                            Investment Company Act of 1940;

                    (e) |_| An investment  adviser in accordance with Rule 13d-1
                            (b)(1)(ii)(E);

                    (f) |_| An  employee  benefit  plan,  or  endowment  fund in
                            accordance with Rule 13d-1 (b)(1)(ii)(F);

                    (g) |_| A  parent  holding  company  or  control  person  in
                            accordance with Rule 13d-1 (b)(1)(ii)(G);

                    (h) |_| A savings  association as defined in section 3(b) of
                            the Federal Deposit Insurance Act;

                    (i) |_| A church plan that is excluded  from the  definition
                            of an  investment  company  under  section  3(c)(14)
                            of the Investment Company Act of 1940;

                    (j) |_| Group, in accordance with Rule 13d-1 (b)(1)(ii)(J).

                    If this statement is filed pursuant to Rule 13d-1 (c), check
                    this box. |X|

Item 4.  Ownership.

                    (a) Amount beneficially owned:

                    Each  of  the  Reporting  Persons  owns  the  amount  of the
                    Ordinary Shares as set forth on the applicable cover page.

                    (b) Percent of class:

                    Each of the  Reporting  Persons owns the  percentage  of the
                    Ordinary Shares as set forth on the applicable cover page.

                    (c) Number of shares as to which such person has:

                        (i) sole power to vote or to direct the vote:

                        Each of the Reporting Persons has the sole power to vote
                        or direct the vote of the  Ordinary  Shares as set forth
                        on the applicable cover page.

                        (ii) shared power to vote or to direct the vote:

                        Each of the  Reporting  Persons has the shared  power to
                        vote or direct  the vote of the  Ordinary  Shares as set
                        forth on the applicable cover page.

                        (iii) sole power to dispose or to direct the disposition
                        of:

                        Each of the  Reporting  Persons  has the  sole  power to
                        dispose or direct the disposition of the Ordinary Shares
                        as set forth on the applicable cover page.

                        (iv)   shared   power  to   dispose  or  to  direct  the
                        disposition of:

                        Each of the  Reporting  Persons has the shared  power to
                        dispose or direct the disposition of the Ordinary Shares
                        as set forth on the applicable cover page.

Item 5              Ownership of Five Percent or Less of a Class.

                    Not applicable.

Item 6.             Ownership of More than  Five  Percent  on  Behalf of Another
                    Person.

                    Investment  management clients of the Reporting Persons have
                    the ultimate right to any dividends from Ordinary Shares and
                    the proceeds from the sale of Ordinary Shares.

Item 7

                    Identification  and  Classification  of the Subsidiary Which
                    Acquired  the  Security  Being  Reported  on by  the  Parent
                    Holding Company.

                    There are no  subsidiaries  of the Reporting  Persons (other
                    than those which are Reporting  Persons) which hold Ordinary
                    Shares.

Item 8.             Identification and Classification of Members of the Group.

                    Not applicable.

Item 9.             Notice of Dissolution of Group.

                    Not applicable.

Item 10.            Certification.

                    By signing below I certify that, to the best of my knowledge
                    and  belief,  the  securities  referred  to  above  were not
                    acquired  and are not  held for the  purpose  of or with the
                    effect of changing or influencing  the control of the issuer
                    of the  securities and were not acquired and are not held in
                    connection  with  or as a  participant  in  any  transaction
                    having that purpose or effect.

<PAGE>
                                    SIGNATURE

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.

Dated:  February 14, 2000



                                          DEUTSCHE BANK AG



                                          By:/s/ Dr. Dieter Eisele
                                             -----------------------------------
                                             Name:   Dr. Dieter Eisele
                                             Title:  Group Head of Compliance



                                          By:/s/ Dr. Rainer Grimberg
                                             -----------------------------------
                                             Name:   Dr. Rainer Grimberg
                                             Title:  Vice President


<PAGE>
                                                                      EXHIBIT 1

               Consent of Deutsche Asset Management Group Limited

          The  undersigned  agrees that the Schedule  13G/A executed by Deutsche
Bank AG to which this  statement is attached as an exhibit is filed on behalf of
Deutsche Bank AG,  Deutsche  Asset  Management  Group Limited and Deutsche Asset
Management  Limited pursuant to Rule 13d-1(k)(1) of the Securities  Exchange Act
of 1934.

Dated:  February 14, 2000



                                         DEUTSCHE ASSET MANAGEMENT GROUP LIMITED



                                         By:/s/ William Slattery
                                            ------------------------------------
                                            Name:   William Slattery
                                            Title:  Head of Business Risk
<PAGE>
                                                                      EXHIBIT 2

                  Consent of Deutsche Asset Management Limited

          The  undersigned  agrees that the Schedule  13G/A executed by Deutsche
Bank AG to which this  statement is attached as an exhibit is filed on behalf of
Deutsche Bank AG,  Deutsche  Asset  Management  Group Limited and Deutsche Asset
Management  Limited pursuant to Rule 13d-1(k)(1) of the Securities  Exchange Act
of 1934.

Dated:  February 14, 2000



                                         DEUTSCHE ASSET MANAGEMENT LIMITED



                                         By:/s/ William Slattery
                                            ------------------------------------
                                            Name:   William Slattery
                                            Title:  Head of Business Risk



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