TEXAS BIOTECHNOLOGY CORP /DE/
SC 13E4/A, 1998-12-03
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                ADMENDMENT NO. 1
                                       TO
                                 SCHEDULE 13E-4
                         ISSUER TENDER OFFER STATEMENT
     (PURSUANT TO SECTION 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934)

================================================================================


                        TEXAS BIOTECHNOLOGY CORPORATION
                                (Name of Issuer)


                        TEXAS BIOTECHNOLOGY CORPORATION
                      (Name of Person(s) Filing Statement)


                   REDEEMABLE COMMON STOCK PURCHASE WARRANTS
                         (Title of Class of Securities)


                                   88221T112
                     (CUSIP Number of Class of Securities)


                        TEXAS BIOTECHNOLOGY CORPORATION
                         7000 FANNIN STREET, SUITE 1920
                              HOUSTON, TEXAS 77030
                                 (713) 796-8822

                                    Copy to

                                ROBERT G. REEDY
                            PORTER & HEDGES, L.L.P.
                           700 LOUISIANA, 35TH FLOOR
                              HOUSTON, TEXAS 77002
                                 (713) 226-0600
          (Name, Address and Telephone Number of Person Authorized to
              Receive Notices and Communications on Behalf of the
                          Person(s) Filing Statement)

                               NOVEMBER 12, 1998
                      (Date Tender Offer First Published,
                       Sent or Given to Security Holders)
<PAGE>   2

         This Schedule 13E-4 relates to the actions taken by Texas
Biotechnology Corporation (the "Company") to extend the exercise deadline of
its outstanding Redeemable Common Stock Purchase Warrants (the "Warrants") from
5:00 p.m., eastern standard time, on  December 14, 1998 (the "Exercise
Deadline") to 5:00 p.m., eastern standard time, September 30, 1999.  The
Warrants are scheduled to expire at 5:00 p.m., eastern standard time, on
December 14, 1998.

ITEM 1.      SECURITY AND ISSUER.

             (a)     The name of the issuer and the address of its principal
                     executive office are: Texas Biotechnology Corporation,
                     7000 Fannin Street, Suite 1920, Houston, Texas 77030.

             (b)     The exact title and amount of the class of securities being
                     sought are all outstanding Warrants of the Company.  As of
                     November 9, 1998, there were 4,082,500 Warrants
                     outstanding.  Each eligible Warrant is exercisable for one
                     share of Common Stock at a price of $8.44.

             The following officers, directors and affiliates of the Company
own Warrants:

<TABLE>
<CAPTION>
                                                                                             NUMBER OF
                                                                                             WARRANTS
                                                                                           BENEFICIALLY
                                      NAME                           TITLE                     HELD
                        -----------------------------     -------------------------    ---------------------
                           <S>                                      <C>                          <C>
                           James A. Thomson                         Director                     5,000
</TABLE>



             (c)     The Company's common stock, $.005 par value (the "Common
                     Stock"), and the Warrants are traded on the American Stock
                     Exchange (the "ASE").  The Common Stock trades under the
                     symbol TXB.  The following tables sets forth the high and
                     low sales prices for the Common Stock based on closing
                     transactions during each specified period as reported by
                     the ASE:


<TABLE>
<CAPTION>
                                   FISCAL 1998 BID                FISCAL 1997 BID              FISCAL 1996 BID
                                ---------------------           -------------------         ---------------------
                                  HIGH         LOW                HIGH        LOW              HIGH        LOW
                                ---------   ---------           --------    -------         ---------    --------
          <S>                <C>            <C>            <C>       <C>                <C>        <C>
          First Quarter         $ 7 13/16    $ 5 3/8            $ 7 1/4     $ 3 7/8          $ 5 1/2      $ 2
                                                                                                          
          Second Quarter          9 1/2        3 3/4              6 3/16      3 3/4            6 9/16       3 1/2
                                                                                                          
          Third Quarter           6            2 9/16             6 1/2       4 9/16           4 7/16       2 3/8
                                                                                                          
          Fourth Quarter                                          6 11/16     5                4 3/4        2 15/16
</TABLE>




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<PAGE>   3
             The Warrants trade under the symbol TXBws.  The following table
             sets forth the high and low sales prices for the Warrants as
             reported by the ASE.

<TABLE>
<CAPTION>
                                  FISCAL 1998 BID           FISCAL 1997 BID              FISCAL 1996 BID
                                -------------------       -------------------         ---------------------
                                   HIGH      LOW             HIGH      LOW              HIGH         LOW
                                ---------  --------       ---------  --------         ---------   ---------
<S>                             <C>       <C>          <C>       <C>              <C>           <C>
               First Quarter    $ 1 1/2    $ 9/16         $ 2 3/8    $ 11/16          $ 1 1/4        $ 1/4

               Second Quarter     2 3/4      1/8            1 1/2       3/4             1 7/8          9/16

               Third Quarter        5/8      1/8            1 9/16      7/8             1 1/8          9/16

               Fourth Quarter                               1 5/8       7/8             1 1/16         1/2
</TABLE>

             (d)     Not applicable.

ITEM 2.      SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION.

             (a)     No funds or other consideration are being offered by the
                     Company for the extension of the Exercise Deadline.

             (b)     Not applicable.

ITEM 3.      PURPOSE OF THE TENDER OFFER AND PLANS OR PROPOSALS OF THE ISSUER
             OR AFFILIATE.

             The purpose of the tender offer is to extend the Exercise Deadline
             of the Warrants to 5:00 p.m., eastern standard time, September
             30, 1999.  The Company believes that this extension of the Exercise
             Deadline will provide Warrant holders an opportunity to benefit
             from exercise of a portion of their Warrants.  There are no
             present plans or proposals which relate to or would result in:

             (a)     The acquisition by any person of additional securities of
                     the issuer, or the disposition of securities of the
                     issuer;

             (b)     An extraordinary corporate transaction, such as a merger,
                     reorganization or liquidation, involving the issuer or any
                     of its subsidiaries;

             (c)     A sale or transfer of a material amount of assets of the
                     issuer or any of its subsidiaries;

             (d)     Any changes in the present board of directors or
                     management of the issuer including, but not limited to,
                     any plans or proposals to change the number or the terms
                     of directors, to fill any existing vacancy on the board or
                     to change any material term of the employment contract of
                     any executive officer;

             (e)     Any material change in the present dividend rate or
                     policy, or indebtedness or capitalization of the issuer;

             (f)     Any other material change in the issuer's corporate
                     structure or business, including, if the issuer is a
                     registered closed-end investment company, any plans or
                     proposals to make any changes in its investment policy for
                     which a vote would be required by Section 13 of the
                     Investment Company Act of 1940;




                                      3
<PAGE>   4
             (g)     Changes in the issuer's charter, bylaws or instruments
                     corresponding thereto or other actions which may impede
                     the acquisition of control of the issuer by any person;

             (h)     Causing a class of equity security of the issuer to be
                     delisted from a national securities exchange or to cease
                     to be authorized to be quoted in an inter-dealer quotation
                     system of a registered national securities association;

             (i)     A class of equity security of the issuer becoming eligible
                     for termination of registration pursuant to Section
                     12(g)(4) of the Act; or

             (j)     The suspension of the issuer's obligation to file reports
                     pursuant to Section 15(d) of the Act.

ITEM 4.      INTEREST IN SECURITIES OF THE ISSUER.

             None.

ITEM 5.      CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH
             RESPECT TO THE ISSUER'S SECURITIES.

             None.

ITEM 6.      PERSONS RETAINED, EMPLOYED OR TO BE COMPENSATED.

             The Company will bear all expenses incurred in connection with the
             tender offer.  Corporate Investor Communications, Inc has been
             engaged to distribute materials and perform certain ministerial
             services in connection with the tender offer for a fee of
             approximately $450, plus out-of-pocket expenses.  Brokerage
             houses, banks and other custodians, nominees and fiduciaries will
             be reimbursed for their customary out-of-pocket and reasonable
             expenses incurred in forwarding tender offer materials to their
             clients who are beneficial owners of the Warrants.

ITEM 7.      FINANCIAL INFORMATION.

             (a)     None.

             (b)     Not applicable.

ITEM 8.      ADDITIONAL INFORMATION.

             (a)     None.

             (b)     Upon termination of the tender offer the Company will
                     notify the ASE of the extension of the Exercise Deadline.

             (c)     Not applicable.

             (d)     None.

             (e)     None.

ITEM 9.      MATERIAL TO BE FILED AS EXHIBITS.

                     (1)      Texas Biotechnology Corporation press release
                              dated November 12, 1998.*

                     (2)      Form of Notice to Warrant Holders dated November
                              12, 1998.*

                     (3)      Response Form.*

             ___________

             * Previously filed.




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<PAGE>   5

                                   SIGNATURE


         After due inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Dated:   December 3, 1998              TEXAS BIOTECHNOLOGY CORPORATION


                                        By: /s/ Stephen L. Mueller
                                        Name: Stephen L. Mueller
                                        Title: Vice President - Finance and
                                        Administration




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<PAGE>   6
                                 EXHIBIT INDEX


Exhibit   (1)    Texas Biotechnology Corporation  press release dated November
                 12, 1998.*

Exhibit   (2)    Form of Notice to Warrant Holders dated November 12, 1998.*

Exhibit   (3)    Response Form.*

_________

* Previously filed.




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