DIACRIN INC /DE/
S-8, 1997-01-10
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>   1
             As filed with the Securities and Exchange Commission
                              on January 10, 1997

                                              Registration No. 333-
================================================================================

                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                                   FORM S-8

                         REGISTRATION STATEMENT UNDER
                          THE SECURITIES ACT OF 1933

                                DIACRIN, INC.
            (Exact name of registrant as specified in its charter)

             DELAWARE                                  22-3016912
      (State or other jurisdiction of             (I.R.S. Employer
      incorporation or organization)              Identification Number)

           CHARLESTOWN NAVY YARD
           BUILDING 96, 13TH STREET
           CHARLESTOWN, MASSACHUSETTS                02129
       (Address of Principal Executive Offices)    (Zip Code)

                      1994 DIRECTORS' STOCK OPTION PLAN
                           (Full title of the Plan)

                               THOMAS H. FRASER
                    PRESIDENT AND CHIEF EXECUTIVE OFFICER
                                DIACRIN, INC.
                            CHARLESTOWN NAVY YARD
                           BUILDING 96, 13TH STREET
                       CHARLESTOWN, MASSACHUSETTS 02129
                     (Name and address of agent for service)
                                (617) 242-9100
        (Telephone number, including area code, of agent for service)

                     -----------------------------------

                                WITH A COPY TO

                            STEVEN D. SINGER, ESQ.
                              HALE AND DORR LLP
                               60 STATE STREET
                         BOSTON, MASSACHUSETTS  02109



<PAGE>   2

<TABLE>

================================================================================

                      CALCULATION OF REGISTRATION FEE

<CAPTION>
                                  Proposed    Proposed
      Title of                    maximum     maximum
      securities     Amount       offering    aggregate        Amount of
      to be          to be        price       offering         registration
      registered     registered   per share   price            fee
      ----------     ----------   ---------   ---------        ------------

      <S>            <C>          <C>         <C>              <C>
      Common         30,000       $11.13(1)   $333,900(1)      $101.18
      Stock,         shares
      $0.01 par
      value per share
- --------------------------------------------------------------------------------
<FN>

      (1)  Estimated solely for the purpose of calculating the registration fee
           and based upon the average of the high and low trading prices of the
           Registrant's Common Stock, as reported on the Nasdaq National Market
           on January 3, 1997, in accordance with Rules 457(c) and 457(h) of
           the Securities Act of 1933, as amended.
================================================================================
</TABLE>


<PAGE>   3


         PART I.  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

                   The information required by Part I of Form S-8 is included in
         documents sent or given to participants in the 1994 Directors' Stock
         Option Plan of Diacrin, Inc., a Delaware corporation (the
         "Registrant"), pursuant to Rule 428(b)(1) of the Securities Act of
         1933, as amended (the "Securities Act").


         PART II.  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

              Item 3.  Incorporation of Certain Documents by Reference
                       -----------------------------------------------

                   The following documents, which are filed with the Securities
         and Exchange Commission (the "Commission"), are incorporated in this
         Registration Statement by reference:

                   (1) The Registrant's latest annual report filed pursuant to
              Sections 13(a) or 15(d) of the Securities Exchange Act of 1934, as
              amended (the "Exchange Act"), or the latest prospectus filed
              pursuant to Rule 424(b) under the Securities Act that contains
              audited financial statements for the Registrant's latest fiscal
              year for which such statements have been filed.

                   (2) All other reports filed pursuant to Sections 13(a) or
              15(d) of the Exchange Act since the end of the fiscal year covered
              by the prospectus referred to in (1) above.

                   (3) The description of the common stock of the Registrant,
              $0.01 par value per share (the "Common Stock"), contained in the
              Registrant's Registration Statement on Form 10 filed under the
              Exchange Act, including any amendment or report filed for the
              purpose of updating such information.

                   All documents subsequently filed by the Registrant pursuant
         to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the
         filing of a post-effective amendment which indicates that all shares of
         Common Stock offered hereby have been sold or which deregisters all
         shares of Common Stock then remaining unsold, shall be deemed to be
         incorporated by reference herein and to be part hereof from the date of
         the filing of such documents.


              Item 4.  Description of Securities
                       -------------------------

                   Not applicable.



                                      -2-
<PAGE>   4



              Item 5.  Interests of Named Experts and Counsel
                       --------------------------------------

                   Steven D. Singer, a partner of Hale and Dorr LLP, is
         Secretary of the Registrant.

              Item 6.  Indemnification of Directors and Officers
                       -----------------------------------------

                   Section 145 of the General Corporation Law of Delaware
         provides that a corporation has the power to indemnify a director,
         officer, employee or agent of the corporation and certain other persons
         serving at the request of the corporation in related capacities against
         amounts paid and expenses incurred in connection with an action or
         proceeding to which such person is or is threatened to be made a party
         by reason of such position, if such person shall have acted in good
         faith and in a manner reasonably believed to be in or not opposed to
         the best interests of the corporation, and, in any criminal proceeding,
         if such person had no reasonable cause to believe such conduct was
         unlawful; provided that, in the case of actions brought by or in the
         right of the corporation, no indemnification shall be made with respect
         to any matter as to which such person shall have been adjudged to be
         liable to the corporation unless and only to the extent that the
         adjudicating court determines that such indemnification is proper under
         the circumstances.

                   Article Eleventh of the Registrant's Certificate of
         Incorporation provides that a director or officer of the Registrant (a)
         shall be indemnified by the Registrant against all expenses (including
         attorney's fees), judgments, fines and amounts paid in settlement
         reasonably incurred in connection with any litigation or other legal
         proceeding (other than an action by or in the right of the Registrant)
         brought against such director or officer by virtue of a position as a
         director or officer of the Registrant if such director or officer acted
         in good faith and in a manner reasonably believed by such director to
         be in or not opposed to the best interests of the Registrant, and, with
         respect to any criminal action or proceeding, such director had no
         reasonable cause to believe such conduct was unlawful and (b) shall be
         indemnified by the Registrant against expenses (including attorneys'
         fees) and amounts paid in settlement reasonably incurred in connection
         with any action by or in the right of the Registrant by virtue of a
         position as a director or officer of the Registrant if such officer or
         director acted in good faith and in a manner reasonably believed to be
         in or not opposed to the best interests of the Registrant, except that
         no indemnification shall be made with respect to any such matter as to
         which such director or officer shall have been adjudged to be liable to
         the Registrant, unless and only to the extent that a court determines
         that, despite the adjudication of liability but in view of all the
         circumstances of the case, such person is fairly and reasonably
         entitled to indemnity for such expenses as the court deems proper.
         Notwithstanding the foregoing, to the extent that a director or officer
         has been successful, on the merits or otherwise, such



                                      -3-
<PAGE>   5


         person shall be indemnified against all expenses (including attorney's
         fees) reasonably incurred in connection therewith. Expenses incurred in
         defending a civil or criminal action, suit or proceeding shall be
         advanced by the Registrant to a director or officer, at such person's
         request, upon receipt of an undertaking by the director or officer to
         repay such amount if it is ultimately determined that such person is
         not entitled to indemnification.

                   Indemnification is required to be made unless the Registrant
         determines that the applicable standard of conduct required for
         indemnification has not been met. In the event of a determination by
         the Registrant that the director or officer did not meet the applicable
         standard of conduct required for indemnification, or if the Registrant
         fails to make an indemnification payment within 60 days after such
         payment is claimed by such person, such person is permitted to petition
         a court to make an independent determination as to whether such person
         is entitled to indemnification. As a condition precedent to the right
         of indemnification, the director or officer must give the Registrant
         notice of the action for which indemnity is sought and the Registrant
         has the right to participate in such action or assume the defense
         thereof.

                   Article Eleventh of the Registrant's Certificate of
         Incorporation further provides that the indemnification provided
         therein is not exclusive, and provides that in the event that the
         Delaware General Corporation Law is amended to expand the
         indemnification permitted to directors or officers, the Registrant
         shall indemnify those persons to the fullest extent permitted by such
         law as so amended.

                   Article Seventh of the Registrant's Certificate of
         Incorporation provides that, except to the extent that the General
         Corporation Law of Delaware prohibits the elimination or limitation of
         liability of directors for breaches of fiduciary duty, no director of
         the Registrant shall be personally liable to the Registrant or its
         stockholders for monetary damages for any breach of fiduciary duty as a
         director.

                   The Registrant has purchased a general liability insurance
         policy which covers certain liabilities of directors and officers of
         the Registrant arising out of claims based on acts or omissions in
         their capacity as directors or officers.

              Item 7.  Exemption from Registration Claimed
                       -----------------------------------

                   Not applicable.



                                      -4-
<PAGE>   6



              Item 8.  Exhibits
                       --------

                   The Exhibit Index immediately preceding the exhibits is
         incorporated herein by reference.


              Item 9.  Undertakings
                       ------------

              1.   The Registrant hereby undertakes:

                   (a) To file, during any period in which offers or sales are
              being made, a post-effective amendment to this Registration
              Statement:

                  (i)   To include any prospectus required by Section 10(a)(3)
                        of the Securities Act;

                 (ii)   To reflect in the prospectus any facts or events arising
                        after the effective date of the Registration Statement
                        (or the most recent post-effective amendment thereof)
                        which, individually or in the aggregate, represent a
                        fundamental change in the information set forth in the
                        Registration Statement; and

                (iii)   To include any material information with respect to the
                        plan of distribution not previously disclosed in the
                        Registration Statement or any material change to such
                        information in the Registration Statement;

              PROVIDED, HOWEVER, that paragraphs (i) and (ii) do not apply if 
              the Registration Statement is on Form S-3 or Form S-8, and the
              information required to be included in a post-effective amendment
              by those paragraphs is contained in periodic reports filed with or
              furnished to the Commission by the Registrant pursuant to Section
              13 or Section 15(d) of the Exchange Act that are incorporated by
              reference in the Registration Statement.

                   (b) That, for the purpose of determining any liability under
              the Securities Act, each such post-effective amendment shall be
              deemed to be a new Registration Statement relating to the
              securities offered therein, and the offering of such securities at
              that time shall be deemed to be the initial bona fide offering
              thereof.

                   (c) To remove from registration by means of a post-effective
              amendment any of the securities being registered which remain
              unsold at the termination of the offering.

              2.  The Registrant hereby undertakes that, for purposes of 
         determining any liability under the Securities Act, each filing of



                                      -5-
<PAGE>   7


         the Registrant's annual report pursuant to Section 13(a) or Section
         15(d) of the Exchange Act (and, where applicable, each filing of an
         employee benefit plan's annual report pursuant to Section 15(d) of the
         Exchange Act) that is incorporated by reference in the Registration
         Statement shall be deemed to be a new Registration Statement relating
         to the securities offered therein, and the offering of such securities
         at that time shall be deemed to be the initial bona fide offering
         thereof.

              3. Insofar as indemnification for liabilities arising under the
         Securities Act may be permitted to directors, officers and controlling
         persons of the Registrant pursuant to the foregoing provisions, or
         otherwise, the Registrant has been advised that in the opinion of the
         Securities and Exchange Commission such indemnification is against
         public policy as expressed in the Securities Act and is, therefore,
         unenforceable. In the event that a claim for indemnification against
         such liabilities (other than the payment by the Registrant of expenses
         incurred or paid by a director, officer or controlling person of the
         Registrant in the successful defense of any action, suit or proceeding)
         is asserted by such director, officer or controlling person in
         connection with the securities being registered, the Registrant will,
         unless in the opinion of its counsel the matter has been settled by
         controlling precedent, submit to a court of appropriate jurisdiction
         the question whether such indemnification by it is against public
         policy as expressed in the Securities Act and will be governed by the
         final adjudication of such issue.



                                      -6-
<PAGE>   8


                                     SIGNATURES

              Pursuant to the requirements of the Securities Act, the Registrant
         certifies that it has reasonable grounds to believe that it meets all
         of the requirements for filing on Form S-8 and has duly caused this
         Registration Statement to be signed on its behalf by the undersigned,
         thereunto duly authorized, in the City of Boston, Commonwealth of
         Massachusetts, this 10th day of January, 1997.


                                          DIACRIN, INC.
                                        
                                        
                                        
                                        
                                          By: /s/ Thomas H. Fraser
                                              --------------------------------
                                              Thomas H. Fraser
                                              President and
                                              Chief Executive Officer




                                 POWER OF ATTORNEY

              We, the undersigned officers and directors of Diacrin, Inc.,
         hereby severally constitute and appoint Thomas H. Fraser, Mark J.
         Fitzpatrick, Steven D. Singer and Jonathan Wolfman , and each of them
         singly, our true and lawful attorneys with full power to them, and each
         of them singly, to sign for us and in our names, in the capacities
         indicated below, the Registration Statement on Form S-8 filed herewith,
         and any and all subsequent amendments to said Registration Statement,
         and generally to do all such things in our names and on our behalf and
         in our capacities as officers and directors to enable Diacrin, Inc. to
         comply with the provisions of the Securities Act of 1933, as amended,
         and all requirements of the Securities and Exchange Commission, hereby
         ratifying and confirming our signatures as they may be signed by our
         said attorneys, or any of them, to said Registration Statement and any
         and all amendments thereto.



                                      -7-
<PAGE>   9


              Pursuant to the requirements of the Securities Act, this
         Registration Statement has been signed below by the following persons
         in the capacities and on the dates indicated.

                 Signature                    Title                  Date
                 ---------                    -----                  ----

         /s/ Thomas H. Fraser          President, Chief        January 10, 1997
         ------------------------        Executive Officer 
         Thomas H. Fraser                and Director      
                                         (Principal        
                                          Executive        
                                          Officer)         
                                         

         /s/ Mark J. Fitzpatrick       Vice President of       January 10, 1997
         ------------------------        Finance and            
         Mark J. Fitzpatrick             Administration         
                                         and Chief              
                                         Financial Officer      
                                         (Principal Financial   
                                         and Accounting Officer)


                   *                   Director                January 10, 1997
         ------------------------
         Zola P. Horovitz


                   *                   Director                January 10, 1997
         ------------------------
         John W. Littlechild


                                       Director                January   , 1997
         ------------------------
         Stelios Papadopoulos

                                       Director                January   , 1997
         ------------------------
         Henri Termeer 

         *By:  /s/ Mark J. Fitzpatrick
               ---------------------------
               Mark J. Fitzpatrick
               Attorney-in-fact



                                      -8-
<PAGE>   10


                                   Exhibit Index


    Exhibit
    Number       Description                           
    ------       -----------                           

       4.1 (1)   Amended and Restated Certificate of
                 Incorporation, as amended to date     

       4.2 (2)   Amended and Restated By-laws, as
                 amended to date                       

       4.3 (2)   Specimen Certificate of Common Stock,  
                 $0.01 par value, of the Registrant

       5         Opinion of Hale and Dorr LLP

      23.1       Consent of Hale and Dorr LLP           
                 (included in Exhibit 5)

      23.2       Consent of Arthur Andersen LLP

      24.1       Power of Attorney (included on the signature  
                 page of this Registration Statement)

      24.2       Power of Attorney of Zola P. Horovitz

      24.3       Power of Attorney of John W. Littlechild

    -----------------------
     (1)  Incorporated herein by reference to the Registrant's Annual Report on
          Form 10-K (File No. 0-20139) for the year ended December 13, 1995.

     (2)  Incorporated herein by reference to the Registrant's Registration
          Statement on Form S-2 (File No. 33-80773).



                                      -9-

<PAGE>   1

                          [HALE AND DORR LETTERHEAD]
                                                                      EXHIBIT 5


                                   January 10, 1997




         Diacrin, Inc.
         Charlestown Navy Yard
         Building 96, 13th Street
         Charlestown, MA  02129

              Re:  1994 Directors' Stock Option Plan --
                   Registration Statement on Form S-8
                   ------------------------------------

         Ladies and Gentlemen:

              We have assisted in the preparation of a Registration Statement on
         Form S-8 (the "Registration Statement") to be filed with the Securities
         and Exchange Commission (the "Commission") under the Securities Act of
         1933, as amended (the "Securities Act") relating to 30,000 shares of
         Common Stock, $.01 par value per share (the "Shares"), of Diacrin,
         Inc., a Delaware corporation (the "Company"), issuable under the
         Company's 1994 Directors' Stock Option Plan (the "Plan").

              We have examined the Amended and Restated Certificate of
         Incorporation and Amended and Restated By-Laws of the Company, each as
         amended to date, the Registration Statement and originals, or copies
         certified to our satisfaction, of all pertinent records of the meetings
         of the directors and stockholders of the Company and such other
         documents relating to the Company as we have deemed material for the
         purposes of this opinion.

              In our examination of the foregoing documents, we have assumed the
         genuineness of all signatures, the authenticity of all documents
         submitted to us as originals, the conformity to original documents of
         all documents submitted to us as copies the authenticity of the
         originals of such latter documents and the legal competence of all
         signatories to such documents.

              We assume that the appropriate action will be taken, prior to the
         offer and sale of the Shares to register and qualify the Shares for
         sale under all applicable state securities or "blue sky" laws. We
         express no opinion herein as the laws of any state or jurisdiction
         other than the state laws of the Commonwealth of Massachusetts, the
         Delaware General Corporation Law statute and the federal laws of the
         United States of America. 

              Based upon and subject to the foregoing, we are of the opinion
         that the Shares covered by the Registration Statement have been duly
         authorized for issuance under the Plan and that the Shares, when issued
         against




<PAGE>   2



         payment therefor in accordance with the terms of the Plan and at a
         price per share in excess of the par value per share for such Shares,
         will be validly issued, fully paid and nonassessable.

              It is understood that this opinion is to be used only in
         connection with the offer and sale of the Shares while the Registration
         Statement is in effect.

              We hereby consent to the filing of this opinion with the
         Commission as an exhibit to the Registration Statement in accordance
         with the requirements of Item 601(b)(5) of Regulation S-K under the
         Securities Act and to the use of our name therein. In giving such
         consent, we do not hereby admit that we are in the category of persons
         whose consent is required under Section 7 of the Securities Act or the
         rules and regulations of the Commission.

              Please note that we are opining only as to the matters expressly
         set forth herein, and no opinion should be inferred as to any other
         matter.

                                            Very truly yours,

                                            /s/ HALE AND DORR LLP

                                            HALE AND DORR LLP





<PAGE>   1
                                                                   EXHIBIT 23.2



                      CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS
                      -----------------------------------------


              As independent public accountants, we hereby consent to the
         incorporation by reference in this Registration Statement of Diacrin,
         Inc., on Form S-8 of our report dated January 17, 1996 (except with
         respect to the matters discussed in Note 10, as to which the date is
         March 7, 1996) included in Diacrin, Inc.'s Annual Report on Form 10-K
         for the year ended December 31, 1995 and to all references to our firm
         included in this Registration Statement.




                                            Arthur Andersen LLP



         Boston Massachusetts
         January 8, 1997





<PAGE>   1
                                                                Exhibit 24.2

                              POWER OF ATTORNEY


        KNOW ALL PERSONS BY THESE PRESENTS, that I, the undersigned director of
Diacrin, Inc., a Delaware corporation (the "Corporation"), which is to file
with the Securities and Exchange Commission (the "Commission") under the
provisions of the Securities Act of 1933, as amended, one or more Registration
Statements on Form S-8, or other appropriate form, for the registration of (i)
up to 800,000 shares of Common Stock issuable under the Corporation's 1990
Stock Plan, (ii) up to 30,000 shares of Common Stock issuable under the
Corporation's 1994 Directors' Stock Option Plan, and (iii) up to 400,000 shares
of Common Stock issuable upon the exercise of stock options granted by the
Corporation other than pursuant to the 1990 Stock Plan or the 1994 Directors'
Stock Option Plan, hereby constitute and appoint Thomas H. Fraser, Mark J.
Fitzpatrick, Steven D. Singer and Jonathan Wolfman, and each of them, my true
and lawful attorneys-in-fact and agents, with full power to them and each of
them singly, to act for me and in my name, place and stead, in any and all
capacities, to sign, or cause to be signed electronically, any and all of said
Registration Statements and any and all amendments to the aforementioned
Registration Statements and to file said Registration Statements and amendments
thereto so signed with all exhibits thereto, and any and all other documents in
connection therewith, with the Commission, hereby granting unto said 
attorneys-in-fact and agents, and each of them, full power and authority to do
and perform any and all acts and things requisite and necessary to be done in
and about the premises, as fully to all intents and purposes as I might or
could do in person, hereby ratifying and confirming all that said
attorneys-in-fact and agents or any of them may lawfully do or cause to be done
by virtue hereof.

        IN WITNESS WHEREOF, I have executed this Power of Attorney as of the 
31st day of December, 1996.


                                                /s/ Zola P. Horovitz
                                                --------------------
                                                    Zola P. Horovitz

<PAGE>   1
                                                                Exhibit 24.3

                              POWER OF ATTORNEY


        KNOW ALL PERSONS BY THESE PRESENTS, that I, the undersigned director of
Diacrin, Inc., a Delaware corporation (the "Corporation"), which is to file
with the Securities and Exchange Commission (the "Commission") under the
provisions of the Securities Act of 1933, as amended, one or more Registration
Statements on Form S-8, or other appropriate form, for the registration of (i)
up to 800,000 shares of Common Stock issuable under the Corporation's 1990
Stock Plan, (ii) up to 30,000 shares of Common Stock issuable under the
Corporation's 1994 Directors' Stock Option Plan, and (iii) up to 400,000 shares
of Common Stock issuable upon the exercise of stock options granted by the
Corporation other than pursuant to the 1990 Stock Plan or the 1994 Directors'
Stock Option Plan, hereby constitute and appoint Thomas H. Fraser, Mark J.
Fitzpatrick, Steven D. Singer and Jonathan Wolfman, and each of them, my true
and lawful attorneys-in-fact and agents, with full power to them and each of
them singly, to act for me and in my name, place and stead, in any and all
capacities, to sign, or cause to be signed electronically, any and all of said
Registration Statements and any and all amendments to the aforementioned
Registration Statements and to file said Registration Statements and amendments
thereto so signed with all exhibits thereto, and any and all other documents in
connection therewith, with the Commission, hereby granting unto said
attorneys-in-fact and agents, and each of them, full power and authority to do
and perform any and all acts and things requisite and necessary to be done in
and about the premises, as fully to all intents and purposes as I might or
could do in person, hereby ratifying and confirming all that said
attorneys-in-fact and agents or any of them may lawfully do or cause to be done
by virtue hereof.

        IN WITNESS WHEREOF, I have executed this Power of Attorney as of the 
31st day of December, 1996.


                                                /s/ John W. Littlechild
                                                -----------------------
                                                    John W. Littlechild


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