DIACRIN INC /DE/
SC 13D, 1998-03-09
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                 AMENDMENT NO. 1
                                       TO
                                  SCHEDULE 13D



                    Under the Securities Exchange Act of 1934


                                  DIACRIN, INC.
                 --------------------------------------------------------------

                                (Name of Issuer)

                          Common Stock, $0.01 Par Value
                 --------------------------------------------------------------

                         (Title of Class of Securities)

                                   00025243N1
                 --------------------------------------------------------------
                                      
                                 (CUSIP NUMBER)

                           RHO MANAGEMENT PARTNERS, LP
                                c/o Cedar Fields
                                Cedar Ridge Road
                          Bedminster, New Jersey 07921
                                   908-234-9202

                 --------------------------------------------------------------

                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                               - with copies to -

                             Stephen Rosenberg, Esq.
              Newman Tannenbaum Helpern Syracuse & Hirschtritt LLP
                          900 Third Avenue - 13th Floor
                            New York, New York 10022
                                 (212) 508-6700

                 --------------------------------------------------------------
                                February 26, 1998
             (Date of event which requires filing of this statement)


If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d- 1(b)(3) or (4) check the following box [ ]

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934, as amended ("Act") or otherwise subject to the liabilities of that section
of the Act but shall be subject to all other provisions of the Act.

                                               Page 1 of 8 Pages
                                                     

<PAGE>



- -----------------------                        -------------------------------
CUSIP No. N/A                                            13D
- -----------------------                        -------------------------------
- -------------------------------------------------------------------------------
      1         NAME OF REPORTING PERSONS
                S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

                Rho Management Partners, LP
- -------------------------------------------------------------------------------
      2         CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*      (a) |_|
                                                                       (b) |_|


- -------------------------------------------------------------------------------
      3         SEC USE ONLY


- -------------------------------------------------------------------------------
      4         SOURCE OF FUNDS*

                00
- -------------------------------------------------------------------------------
      5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
                TO ITEM 2(d) or 2(e)                  |_|


- -------------------------------------------------------------------------------
      6         CITIZENSHIP OR PLACE OF ORGANIZATION

                New Jersey

- --------------------------------------------------------------------------------
              NUMBER OF    7      SOLE VOTING POWER
               SHARES
            BENEFICIALLY          1,612,887 shares of Common Stock (See Item 5)
              OWNED BY
                EACH
              REPORTING
             PERSON WITH
- -------------------------------------------------------------------------------
      8       SHARED VOTING POWER

                                                     0
- -------------------------------------------------------------------------------
      9       SOLE DISPOSITIVE POWER

                             1,612,887  shares  of  CommonStock (See Item 5.)
- -------------------------------------------------------------------------------
     10      SHARED DISPOSITIVE POWER

                                                0
- -------------------------------------------------------------------------------

     11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                1,612,887 shares of Common Stock (See Item 5.)
- -------------------------------------------------------------------------------
     12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                CERTAIN SHARES*                                     |_|


- --------------------------------------------------------------------------------
     13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                11.28% of Common Stock  (See Item 5)
- -------------------------------------------------------------------------------
     14         TYPE OF REPORTING PERSON*

                IA/PN
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTIONS BEFORE FILLING OUT

                                               Page 2 of 8 Pages
                                                      

<PAGE>



- ----------------------                        ----------------------------------
CUSIP No. N/A                                            13D
- ----------------------                         ---------------------------------
- -------------------------------------------------------------------------------
      1         NAME OF REPORTING PERSONS
                S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

                Joshua Ruch
- --------------------------------------------------------------------------------
      2         CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a) |_|
                                                                         (b) |_|


- -------------------------------------------------------------------------------
      3         SEC USE ONLY


- -------------------------------------------------------------------------------
      4         SOURCE OF FUNDS*

                00
- -------------------------------------------------------------------------------
      5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
                TO ITEM 2(d) or 2(e)                                        |_|


- -------------------------------------------------------------------------------
      6         CITIZENSHIP OR PLACE OF ORGANIZATION

                Republic of South Africa

- -------------------------------------------------------------------------------
              NUMBER OF      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY           1,667,387 shares of Common Stock (See Item 5)
              OWNED BY
                EACH
              REPORTING
             PERSON WITH
- --------------------------------------------------------------------------------
     8       SHARED VOTING POWER

- -------------------------------------------------------------------------------
      9       SOLE DISPOSITIVE POWER

                 1,667,387  shares  of  Common Stock (See Item 5.)
- -------------------------------------------------------------------------------
    10      SHARED DISPOSITIVE POWER


- -------------------------------------------------------------------------------

     11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                1,667,387 shares of Common Stock (See Item 5.)
- -------------------------------------------------------------------------------
     12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                CERTAIN SHARES*                                            |_|


- -------------------------------------------------------------------------------
     13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                11.66% of Common Stock  (See Item 5)
- ------------------------------------------------------------------------------
     14         TYPE OF REPORTING PERSON*

                IN
- -------------------------------------------------------------------------------

                      *SEE INSTRUCTIONS BEFORE FILLING OUT

                                               Page 3 of 8 Pages
                                                    

<PAGE>



                                                   SCHEDULE 13D


                  This  Amendment  number 1 to  Schedule  13D is being  filed on
behalf of Rho  Management  Partners,  LP,  ("Rho"),  as an  investment  advisor,
regarding  shares  of  Diacrin,  Inc.  acquired  on  behalf  of  certain  of its
investment advisory clients.

Item 1.           Security and Issuer

                  Securities acquired:  Common Stock, $0.01 par value

                  Issuer:       Diacrin, Inc. (the "Issuer")
                                Building 96
                                13th Street
                                Charleston Navy Yard
                                Charleston, Massachusetts  02129


Item 2.           Identity and Background

                  Rho  provides   investment   management  services  to  private
individuals and  institutions.  Rho is located at c/o Cedar Fields,  Cedar Ridge
Road,  Bedminster,  New Jersey 07921.  Rho has not been  convicted in a criminal
proceeding  during the last five (5) years. Rho is not, and during the past five
(5) years was not, a party to a civil proceeding of a judicial or administrative
body of competent jurisdiction and as a result thereof, subject to any judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, federal or state securities laws or finding any
violation with respect to such laws.

                  Mr. Joshua Ruch  ("Ruch") is a controlling  person of Rho. His
business address is 767 Fifth Avenue, New York, New York 10153. Ruch's principal
occupation is investment management and he is a citizen of the Republic of South
Africa.  During the past five (5) years,  Ruch has not been (a)  convicted  in a
criminal proceeding, or (b) a party to any civil proceeding as a result of which
he has been  subject to any  judgment,  decree or final order  enjoining  future
violations  of, or  prohibiting  or mandating  activities  subject to federal or
state securities laws or finding any violation with respect to such laws.



                                               Page 4 of 8 Pages
                                                   

<PAGE>



Item 3.           Source and Amount of Funds

                  Rho acquired  $3,499,996.50  of the common stock of the Issuer
through the working capital of Rho.

Item 4.           Purpose of the Transaction

                  Rho has acquired  shares of Common Stock reported in Item 5(c)
hereof  over  the last  sixty  (60)  days,  and  prior  thereto,  for  portfolio
investment  purposes only, and does not have any present plans or proposals that
relate to or would result in any change in the business,  policies,  management,
structure or capitalization of the Issuer. Rho reserves the right to acquire, or
dispose of, additional  securities of the Issuer or any of its securities in the
ordinary  course of business,  to the extent deemed  advisable in light of their
general  investment and trading policies,  market conditions or other factors. A
representative  of Rho may, in the future,  be elected to the board of directors
of the Issuer.  The Issuer may from time to time contact large shareholders with
a view  towards  discussing  the  acquisition  of their  shares.  Other  than as
described  above, Rho does not have plans or proposals which would result in any
of the following:

                  1)     the acquisition by any person of additional securities
                         of the Issuer, or the disposition of securities of the
                         Issuer;

                  2)     an  extraordinary  corporate  transaction,  such  as  a
                         merger,  reorganization  or liquidation,  involving the
                         Issuer or any of its subsidiaries;

                  3)     a sale or transfer of a material amount of assets of
                         the Issuer or any of its subsidiaries;

                  4)     any  change  in  the  present  board  of  directors  or
                         management  of  the  Issuer,  including  any  plans  or
                         proposals  to change the number or term of directors or
                         to fill any vacancies on the board;

                  5)     any material change in the present capitalization or 
                         dividend policy of the Issuer;

                  6)     any other material change in the Issuer's business o
                         corporate structure;

                  7)     changes in the Issuer's charter, by-laws or instruments
                         corresponding thereto or other actions which may impede
                         the acquisition of control of the Issuer by any person;

                  8)     causing  a class  of  securities  of the  Issuer  to be
                         delisted  from a  national  securities  exchange  or to
                         cease to be authorized  to be quoted in an  interdealer
                         quotation  system of a registered  national  securities
                         association;


                                               Page 5 of 8 Pages
                                                     

<PAGE>



                  9)     causing a class of  securities  of the Issuer to become
                         eligible for  termination of  registration  pursuant to
                         Section 12(g)(4) of the Act; or

                  10) any action similar to any of those enumerated above.


Item 5.           Interest in Securities of the Issuer

                  (a) - (b) As a holder of sole voting and investment  authority
over the  Shares  owned by its  advisory  clients,  Rho may be  deemed,  for the
purposes of Rule 13d-3 under the  Securities and Exchange Act of 1934, to be the
beneficial  owner of all of the 1,612,887  Shares owned by its advisory  clients
and covered by this Statement, representing approximately 11.28% of the Issuer's
14,296,158  Shares  outstanding as of February 28, 1998 (based upon  information
obtained from officials of the Company as of such date), and after giving effect
to Shares subject to options,  warrants,  rights or convertible securities owned
by the reporting  persons.  Rho  disclaims  any economic  interest in the Shares
covered by this Statement.  Through limited partnership interests,  Rho may also
be deemed to have an indirect  interest in  approximately  646,000 shares of the
Issuer owned by the limited partnerships.

                            As controlling person of Rho, Ruch may be deemed the
beneficial  owner of the Shares  beneficially  owned by Rho. In  addition,  Ruch
exercises  investment  and voting  authority  over  54,500  Shares  directly  or
indirectly  for his own  account and the  account of family  members  other than
through  funds  managed  by  Rho.  As a  percentage  of  the  14,296,158  Shares
outstanding  as of  February  28, 1998 (based  upon  information  obtained  from
officials of the Company as of such date),  Ruch may be considered  beneficially
to own through these family members less than 1.00% of the Company's Shares.

                  (c) The  following  presents  a list of  purchases  (including
acquisitions by way of  distributions)  and sales of all Shares by the reporting
persons within the last 60 days,  including the price per Share and the means by
which such purchase or sale was effected.

Date       # Shares       Price/Share      Purchase (P)    Sale (S)    Account

2/26/98     378,378       $9.25             P                              Rho


                  (d) The reporting persons have the right to participate in the
receipt of dividends from, or proceeds from the sale of securities.

                  (e)                  Not Applicable.

Item 6. Contracts, Arrangement, Understandings or Relationships with Respect to
        Securities of the Issuer
                                               Page 6 of 8 Pages
                                                    

<PAGE>



                  Not Applicable.


Item 7.           Material to be Filed as Exhibits

                  Not Applicable

                                               Page 7 of 8 Pages
                                                    

<PAGE>


Signatures

         After  reasonable  inquiry and to the best of our knowledge and belief,
the  undersigned  certifies that the  information set forth in this statement is
true, complete and correct.


Dated:  March 6, 1998


                                                RHO MANAGEMENT PARTNERS, LP
                                                By:     ATLAS CAPITAL CORP.,
                                                        its General Partner


                                       By:  /s/ Joshua Ruch
                                                 Joshua Ruch, President

                                               Page 8 of 8 Pages
                                                     

<PAGE>




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