CELLEGY PHARMACEUTICALS INC
S-3, 1999-08-30
PHARMACEUTICAL PREPARATIONS
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     As filed with the Securities and Exchange Commission on August 30, 1999
                              Registration No. 333-
================================================================================
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                             ----------------------

                                    FORM S-3

                             REGISTRATION STATEMENT
                                      Under
                           THE SECURITIES ACT OF 1933

                             ----------------------

                          CELLEGY PHARMACEUTICALS, INC.
           (Exact name of the Registrant as specified in its charter)

         California                                      82-0429727
(State or other jurisdiction of             (I.R.S. employer identification no.)
incorporation or organization)

                      349 OYSTER POINT BOULEVARD, SUITE 200
                      SOUTH SAN FRANCISCO, CALIFORNIA 94080
                                 (650) 616-2200
 (Address and telephone number of the Registrant's principal executive offices)
                             ----------------------

                               K. MICHAEL FORREST
                             CHIEF EXECUTIVE OFFICER
                          CELLEGY PHARMACEUTICALS, INC.
                      349 OYSTER POINT BOULEVARD, SUITE 200
                          SOUTH SAN FRANCISCO, CA 94080
                                 (650) 616-2200
   (Name, address and telephone number of the Registrant's agent for service)
                             ----------------------

                                   Copies to:
                                 C. KEVIN KELSO
                               FENWICK & WEST LLP
                         TWO PALO ALTO SQUARE, SUITE 800
                           PALO ALTO, CALIFORNIA 94306
                                 (650) 494-0600
                             ----------------------

        Approximate date of commencement of proposed sale to the public:
     From time to time after this Registration Statement becomes effective.

If the only securities  being registered on this Form are being offered pursuant
to dividend or interest reinvestment plans, please check the following box. |_|

If any of the  securities  being  registered on this Form are to be offered on a
delayed or continuous  basis  pursuant to Rule 415 under the  Securities  Act of
1933, check the following box. |X|

If this Form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the  Securities  Act  registration  statement  number of the  earlier  effective
registration statement for the same offering. |_|

If this Form is a  post-effective  amendment filed pursuant to Rule 462(c) under
the  Securities  Act,  check  the  following  box and  list the  Securities  Act
registration  statement number of the earlier effective  registration  statement
for the same offering. |_|

If delivery  of the  prospectus  is  expected  to be made  pursuant to Rule 434,
please check the following box. |_|
<TABLE>
                                                   Calculation Of Registration Fee
<CAPTION>
- -------------------------------------------------- ---------------- ----------------------- ------------------- --------------------
                                                                        Proposed Maximum      Proposed Maximum
  Title of Each Class of shares of common            Amounts to be     Offering Price per    Aggregate Offering       Amount of
          stock to be Registered                     Registered(1)          Share(1)              Price(1)         Registration Fee
- -------------------------------------------------- ---------------- ----------------------- ------------------- --------------------
<S>                                                   <C>                   <C>               <C>                    <C>
common stock, no par value                            1,561,000             $7.03125          $10,975,781.25         $3,051.27
- -------------------------------------------------- ---------------- ----------------------- ------------------- --------------------
common stock issuable upon exercise of warrants          14,000             $7.03125              $98,437.50            $27.37
- -------------------------------------------------- ---------------- ----------------------- ------------------- --------------------
<FN>
(1)  Estimated solely for the purpose of calculating the amount of registration fee pursuant to Rule 457(c) under the Securities Act
     of 1933,  as amended,  based on the average of the high and low prices of the common stock on the Nasdaq Stock Market on August
     24, 1999.

The Registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until
the Registrant  files a further  amendment  which  specifically  states that this  Registration  Statement shall  thereafter  become
effective in accordance with Section 8(a) of the Securities Act of 1933 or until the  Registration  Statement shall become effective
on such date as the Securities and Exchange Commission, acting pursuant to Section 8(a), may determine.
</FN>
</TABLE>
<PAGE>

                  Subject to completion, dated August 30, 1999

- --------------------------------------------------------------------------------

                                   PROSPECTUS

- --------------------------------------------------------------------------------


                          Cellegy Pharmaceuticals, Inc.
                        1,575,000 shares of common stock

              -----------------------------------------------------

              Cellegy's common stock currently trades on the Nasdaq
   Stock Market. Last reported sale price on August 27, 1999 $7.50 per share.
                              Trading Symbol: CLGY

              -----------------------------------------------------

                                  The Offering

The selling  stockholders  named on page 8 of this prospectus may offer and sell
the shares of Common stock offered in this prospectus.  Cellegy will not receive
any of the proceeds from the sale of these shares.

              -----------------------------------------------------

This investment  involves a high degree of risk.  Please carefully  consider the
"Risk Factors" beginning on page 3 of this prospectus.

Neither  the  Securities  and  Exchange  Commission  nor  any  state  securities
commission  has  approved or  disapproved  these  securities  or passed upon the
adequacy or accuracy of this prospectus. Any representation to the contrary is a
criminal offense.

                 The date of this prospectus is August 30, 1999
********************************************************************************
The  information in this  prospectus is not complete and may be changed.  We may
not sell  these  securities  until the  registration  statement  filed  with the
Securities and Exchange Commission is effective. This prospectus is not an offer
to  sell  these  securities  and it is not  soliciting  an  offer  to buy  these
securities in any state where the offer or sale is not permitted.
********************************************************************************



<PAGE>

         In connection  with this offering,  no person is authorized to give any
information or to make any representations not contained in this prospectus.  If
such  information  is given or  representations  made,  you may not rely on such
information or  representations as having been authorized by us. This prospectus
is neither an offer to sell nor a solicitation of an offer to buy any securities
other than those registered hereby, nor is it an offer to sell or a solicitation
of an offer to buy  securities  where  such an  offer or  solicitation  would be
unlawful.  You may not imply from the delivery of this prospectus,  nor from any
sale made under this  prospectus,  that our affairs are unchanged since the date
of this  prospectus  or that the  information  contained in this  prospectus  is
correct as of any time after the date of this prospectus.

              -----------------------------------------------------

                                TABLE OF CONTENTS

              -----------------------------------------------------

Forward-looking Statement .......3   Plan of Distribution..................... 9
The Company .....................3   Where You Can Find More Information .....10
Risk Factors ....................3   Documents Incorporated by Reference .....11
Use of Proceeds .................7   Legal Matters ...........................11
Selling Stockholders ............8   Experts .................................11


         Unless the context otherwise requires,  the terms "we," "our," "us" and
"Cellegy" refer to Cellegy  Pharmaceuticals,  Inc., a California corporation and
its subsidiaries.

                                       2

<PAGE>

                           FORWARD-LOOKING STATEMENT

         This  Registration  Statement  on  Form  S-3  includes  forward-looking
statements.  Words such as "believes,"  "anticipates,"  "expects," "intends" and
similar expressions are intended to identify foward-looking  statements, but are
not the exclusive means of identifying  such statements.  These  forward-looking
statements concern matters that involve risks and uncertainties that could cause
our  actual  results  to differ  materially  from  those in the  forward-looking
statements.  Further,  we undertake no obligation to revise any  forward-looking
statements in order to reflect events or circumstances  that may arise after the
date of this report.  Actual events or results may differ  materially from those
discussed in this prospectus.

                                   THE COMPANY

     We are a specialty bio-pharmaceutical company engaged in the development of
prescription drugs and cosmeceutical  products based on our patented topical and
transdermal drug delivery technologies.

     Cellegy's   most   advanced   prescription   product   candidates   include
Anogesic(R),  a  nitroglycerin-based  product for the treatment of anal fissures
and  hemorrhoids,  and a transdermal  testosterone gel for the treatment of male
hypogonadism, a condition that frequently results in lethargy and reduced libido
in men above the age of 40. We recently  completed patient enrollment in a Phase
III clinical trial using Anogesic for the treatment of chronic anal fissures.

     In addition to prescription drugs, Cellegy is testing and developing a line
of  non-prescription  cosmeceutical  products which we believe will help reverse
the signs of skin aging and address the skin care needs of an affluent and aging
population.

                                  RISK FACTORS

         Please carefully  consider the specific factors set forth below as well
as the other  information  contained in, or incorporated by reference into, this
prospectus  before  purchasing  shares of our common  stock.  Factors that might
cause such a difference include, but are not limited to, those discussed below.

We have a history  of  losses,  and we expect  losses to  continue  for at least
several years.

         Our  accumulated  deficit as of June 30, 1999 was  approximately  $35.1
million.  We have never  operated  profitably  and,  given our planned  level of
operating expenses,  we expect to continue to incur losses for at least the next
several  years.  We plan to increase  our  operating  expenses as we continue to
devote   significant   resources  to  preclinical   studies,   clinical  trials,
administrative,  marketing  and patent  activities.  We have not  generated  any
significant  revenues from  royalties or licensing of our  technologies,  and we
expect that it will take several years for any of the  prescription  products to
be approved for marketing.  Accordingly,  without substantial  revenues from new
corporate  collaborations,  royalties on product sales or other revenue sources,
we expect to incur substantial and increased operating losses in the foreseeable
future as our earlier stage potential  products move into clinical  development,
and as we  invest  in  research  or  acquire  additional  technologies,  product
candidates or businesses.  Our losses may increase in the future, and even if we
achieve  our  revenue  targets,  we may  not be  able  to  sustain  or  increase
profitability  on a quarterly or annual basis.  The amount of future net losses,
and the time  required to reach  profitability,  are both highly  uncertain.  To
achieve  sustained   profitable   operations,   we  must,  among  other  things,
successfully  discover,  develop,  obtain  regulatory  approvals  for and market
pharmaceutical or cosmeceutical products. We cannot assure you that we will ever
be able to achieve or sustain profitability.

Our clinical trial results are very difficult to predict in advance, and failure
of one or more clinical trials could adversely affect our business and our stock
price.

     Before  we  obtain  regulatory  approval  for the  commercial  sale of most
potential drug products,  we must demonstrate  through  preclinical  studies and
clinical trials that the product is safe and efficacious for use in the clinical
indication  for which  approval is sought.  We cannot assure you that we will be
permitted  by the U.S.  Food  and  Drug  Administration  ( the  "FDA")  or other
international  regulatory  authorities to undertake or continue  clinical trials
for any of our potential  products or, if such trials are  permitted,  that such
products will demonstrate safety and efficacy.  Moreover, results of preclinical
studies and early  clinical  trials may not be good  predictors  of results that
will be obtained  in  later-stage  clinical  trials.  We cannot  assure you that
Cellegy's present or future clinical trials,  including for example, the current
Phase II and III  clinical  trials using our  Anogesic  product,  or the current
Phase II dose ranging study for  testosterone  gel, will demonstrate the results
required  for approval to market  these  potential  products or even to continue
with  additional  clinical  development.  Because of the  independent  and blind
nature of certain human clinical testing,  there will be extended periods during
the testing process when we will have only limited, or no, access to information
about the status or results of the tests.  Other  pharmaceutical  companies have
believed that their products  performed  satisfactorily  in early tests, only to
find their  performance in later tests,  including Phase III clinical trials, to
be inadequate or unsatisfactory,  or that FDA Advisory

                                       3

<PAGE>

Committees  have  declined to recommend  approval of the drugs,  or that the FDA
itself refused approval,  with the result that such companies' stock prices have
fallen  precipitously.  If Anogesic fails to  successfully  complete its current
Phase III or any future clinical  testing,  including  toxicology  studies,  our
business and stock price would be materially and adversely affected.

Our potential products are in early stages of product  development,  and we have
not sought regulatory approval to distribute any products.

         To date,  we have not sought  regulatory  approval  to  distribute  any
products.  The time and resource  commitment  required to achieve market success
for any individual product is extensive and uncertain. We cannot assure you that
our product  development  efforts will be successful,  that required  regulatory
approvals can be obtained,  that potential  products can be  manufactured  at an
acceptable cost and with appropriate  quality or that any approved  products can
be successfully marketed.

         With the exception of certain skin care cosmeceutical products, Cellegy
has not yet completed the  development  of other  products or sought  regulatory
approval for the  marketing of our drug products and have not begun to market or
generate revenues from our prescription  products.  Development of our potential
products will require significant  additional research and development.  Many of
Cellegy's   product   development   efforts  are  based  upon  technologies  and
therapeutic  approaches  that have not been  widely  tested  or used.  Moreover,
Cellegy's  beliefs  regarding the therapeutic  and commercial  potential for its
products  are based on studies  conducted  to date,  and later  studies  may not
support Cellegy's current beliefs. In addition,  results of our studies have not
been published in medical journals or reviewed by independent third parties, and
as a result  have not been  subjected  to the same degree of scrutiny as results
that have been published or subjected to review by independent parties.

     Cellegy's  potential  products are subject to the risks of failure inherent
in the  development  of all products based on new  technologies.  These possible
risks include:

     o   Cellegy's therapeutic approaches will not be successful;

     o   the results  from future  clinical  trials may not  correlate  with any
         safety or efficacy  results from prior  clinical  studies  conducted by
         Cellegy or others;

     o   Cellegy's potential products will not be successfully developed;

     o   products  will not be found to be safe  and  effective  by the FDA,  or
         other international regulatory agencies;

     o   our future  clinical and research and  development  activities will not
         result in any commercially viable products.

Possible FDA regulation of our  cosmeceutical  products as drugs would adversely
impact our planned marketing program.

         Cellegy  intends  to  introduce  products  that  will  compete  in  the
cosmeceutical  market,  including  a product  line that will  compete in what is
generally referred to as the "anti-wrinkling"  market.  "Cosmeceuticals" are not
defined in the Food,  Drug and Cosmetics  Act (the "FD&C Act").  The FDA has not
defined  the  term by  regulation  and may  consider  use of the  term to  imply
drug-like  qualities.  Cosmeceuticals  (a hybrid of the  words  "cosmetics"  and
"pharmaceuticals")  are products that contain  active  ingredients  which,  when
applied to the skin, will enhance appearance.  Cosmeceuticals  which satisfy the
definition  of a cosmetic  under the FD&C Act and which are not also drugs under
that statute are not subject to the same FDA requirements as drug products.  The
FDA may contend that one or more cosmeceutical products,  including Cellegy's or
competitors'  anti-wrinkling  products that are currently marketed or may in the
future be marketed,  are not  cosmetics but instead are subject to regulation as
drugs.

Competition and technological change is increasing.  In the future,  Cellegy may
not have the resources required to develop innovative products.

         The  pharmaceutical  and cosmeceutical  industries are subject to rapid
and  significant  technological  change.  In the  development  and  marketing of
topical prescription drugs, skin care and other cosmeceutical  products and drug
delivery systems,  Cellegy faces intense competition.  Competitors of Cellegy in
the United  States and abroad are  numerous  and include,  among  others,  major
pharmaceutical,   chemical,   cosmetic,   consumer  product,  and  biotechnology
companies,  specialized  firms,  universities  and other research  institutions.
Cellegy's  competitors may succeed in developing  technologies and products that
are more effective  than any which we are developing and could render  Cellegy's
technology and potential  products  obsolete and  noncompetitive.  Many of these
competitors  have  substantially  greater  financial  and

                                       4

<PAGE>

technical  resources,   clinical  production  and  marketing   capabilities  and
regulatory  experience.  In addition,  these companies and academic and research
institutions  compete  with us in  recruiting  and  retaining  highly  qualified
scientific  and  management  personnel.  As a result,  we cannot assure you that
Cellegy's  products under development will be able to compete  successfully with
existing   products  or  innovative   products   under   development   by  other
organizations.

The type and scope of patent  coverage we have may limit the commercial  success
of our products.

     Cellegy's  success  depends,  in part,  on our  ability  to  obtain  patent
protection for our products and methods,  both in the United States and in other
countries.  Several of Cellegy's products are based on existing compounds with a
history of use in humans but are being  developed by Cellegy for new therapeutic
use in skin  diseases.  Cellegy cannot obtain  composition  patent claims on the
compound  itself,  and  will  instead  need to rely on  patent  claims,  if any,
directed  to use of the  compound  to treat  certain  conditions  or to specific
formulations we are attempting to develop.  Cellegy may not be able to prevent a
competitor from using our formulations or compounds for a different purpose.  We
cannot assure you that any  additional  patents will be issued to Cellegy,  that
the protection of any patents issued in the future will be commercially valuable
or that current or future patents will be held valid if subsequently challenged.

     The patent  position of companies  engaged in businesses  such as Cellegy's
business   generally  is  uncertain  and  involves  complex  legal  and  factual
questions.  There is a substantial  backlog of patent applications at the United
States Patent and Trademark  Office.  Further,  issued patents can later be held
invalid by the patent office  issuing the patent or by a court.  There can be no
assurance that any patent applications relating to Cellegy's products or methods
will issue as patents,  or, if issued,  that the patents will not be challenged,
invalidated or circumvented  or that the rights granted  thereunder will provide
us a competitive advantage. In addition, many other organizations are engaged in
research  and product  development  efforts in drug  delivery,  skin biology and
cosmeceutical   fields  that  may  overlap   with   Cellegy's   products.   Such
organizations may currently have, or may obtain in the future,  legally blocking
proprietary rights,  including patent rights, in one or more products or methods
under development or consideration by Cellegy.  These rights may prevent us from
commercializing  technology, or may require Cellegy to obtain a license from the
organizations to use the technology.  Cellegy may not be able to obtain any such
licenses that may be required on reasonable  financial terms, if at all, or that
the patents underlying any such licenses will be valid or enforceable. Moreover,
the laws of certain  foreign  countries  do not  protect  intellectual  property
rights  relating to United  States  patents as  extensively  as those rights are
protected in the United States.  Cellegy is subject to the risk that individuals
or organizations located in such countries will engage in development, marketing
or sales activities of Cellegy's products.

     Our agreements with the University of California give us exclusive  license
rights to certain drug  delivery  and other  technologies  that contain  certain
development  and performance  milestones  which Cellegy must satisfy in order to
retain such rights.  While we  currently  believe we will be able to satisfy the
revised  milestone  dates, a loss of rights to these  technologies  could have a
material adverse effect on our business and stock price.

Our product sales strategy involving corporate partners is highly uncertain.  No
new partnership agreements have been finalized.

     Cellegy is actively seeking to enter into agreements with certain corporate
partners  granting  rights to  commercialize  our lead products.  Cellegy has an
agreements  with one  academic  institution,  and  intends  to enter  into other
collaborative agreements in the future. Cellegy may rely on its partners to:

     o   conduct clinical trials;
     o   to obtain regulatory approvals; and,
     o   if approved, to manufacture and market or co-promote these products.

     Once  agreements are completed,  Cellegy may have little or no control over
the  development  of these  potential  products and little or no  opportunity to
review clinical data before or after public  announcement  of results.  Further,
Cellegy may not be able to establish any such  collaborative  arrangements,  and
any arrangements that may be established may not be successful. Failure to enter
into any such  arrangements  could have a material adverse effect on our ability
to develop  and  market  our  products,  particularly  in certain  international
markets.  If we are unable to find  another  corporate  partner  to develop  and
market Glylorin, it may never be commercialized.

We are  subject to  regulation  by  regulatory  authorities  including  the FDA;
obtaining  approval  to  market  drugs  is a  lengthy  process,  and  regulatory
authorities could delay or prevent marketing of our products.

                                       5

<PAGE>

         The   research,    development,    testing,   manufacture,    labeling,
distribution,  marketing and advertising of products such as Cellegy's products,
and our ongoing  research and development  activities,  are subject to extensive
regulation by governmental regulatory authorities in the United States and other
countries.  The extensive  preclinical  and clinical  testing  requirements  and
regulatory  approval  process  of the FDA in the  United  States  and of certain
foreign regulatory  authorities require a number of years and the expenditure of
substantial resources.  We may not be able to obtain the necessary approvals for
clinical  testing or for the  marketing of products on a timely basis or at all.
Moreover,  additional  government  regulations  may be  established  that  could
prevent or delay regulatory approval of Cellegy's products.  Delays in obtaining
regulatory  approvals  could have a material  adverse effect on our business and
stock price. Even if regulatory approval of a product is granted,  such approval
may include significant  limitations on the indicated uses of the product or the
manner in which or conditions under which the product may be marketed. Moreover,
failure to comply  with  regulatory  requirements  for  marketing  drugs,  or if
Cellegy's  cosmeceutical  products  are  deemed  to be drugs  by the FDA,  could
subject Cellegy to regulatory or judicial  enforcement actions,  including,  but
not limited to, product  recalls or seizures,  injunctions  against  production,
distribution,  sales and marketing,  civil  penalties,  criminal  prosecution of
Cellegy,  our  officers  or  employees,  refusals to approve  new  products  and
suspensions  and  withdrawals  of  existing  approvals,  as well as  potentially
increased product liability  exposure.  Sales of Cellegy's  products outside the
United  States will be subject to  regulatory  requirements  governing  clinical
trials and marketing  approval.  These  requirements vary widely from country to
country and could delay introduction of Cellegy's products in those countries.

Our prospects for obtaining additional financing, if required, are uncertain and
failure to obtain needed financing could affect our ability to develop or market
products.

     Throughout our history,  we have consumed  substantial amounts of cash. Our
cash needs are expected to continue to increase  significantly over at least the
next several years in order to fund the additional  expenses  required to expand
our current research and development programs.  Cellegy has no current source of
significant  ongoing  revenues or capital beyond existing cash and  investments,
and product sales to Gryphon, the development  subsidiary of specialty retailer,
Bath & Body Works.  In order to complete the research and  development and other
activities necessary to commercialize our products, additional financing will be
required.

     Cellegy  will  seek  private  or  public  equity   investments  and  future
collaborative  arrangements  with third  parties to help fund future cash needs.
Such funding may not be available on acceptable  terms, if at all.  Insufficient
funding may require  Cellegy to delay,  reduce or  eliminate  some or all of our
research and development activities or planned clinical trial programs.  Cellegy
believes that available  cash resources and interest  earned will be adequate to
satisfy its capital needs through at least December 31, 2000.

We  currently  have no  products we sell on our own and have  limited  sales and
marketing experience.

         We may market certain of our products,  if  successfully  developed and
approved,  through a direct sales force in the United  States and through  sales
and  marketing  partnership  or  distribution  arrangements  outside  the United
States.   Cellegy  has  no  history  or  experience   in  sales,   marketing  or
distribution.  To  market  our  products  directly,  we intend  to  establish  a
marketing group and direct sales force or obtain the assistance of our marketing
partner.  If we enter into marketing or licensing  arrangements with established
pharmaceutical  companies,  our  revenues  will  be  subject  to the  terms  and
conditions  of such  arrangements  and will be  dependent  on the efforts of our
partner. Cellegy may not be able to successfully establish a direct sales force,
or assure  you that our  collaborators  may not  effectively  market  any of our
potential products, and either circumstance could have a material adverse effect
on our business and stock price.

We have not  manufactured  products before and are dependent on a limited number
of critical suppliers.

         Cellegy has no direct experience in manufacturing commercial quantities
of products and currently does not have any capacity to manufacture  products on
a large  commercial  scale.  We currently  rely on a limited  number of contract
manufacturers and suppliers to manufacture our formulations. Although we believe
that there will be adequate third party manufacturers, there can be no assurance
that we will be able to enter  into  acceptable  agreements  with  them.  In the
future,  we may not be able to obtain  contract  manufacturing  on  commercially
acceptable  terms for  compounds or product  formulations  in the  quantities we
need.  Manufacturing  or quality  control  problems  could occur at the contract
manufacturers  such that they may not be able to  maintain  compliance  with the
FDA's current good  manufacturing  practice  requirements  necessary to continue
manufacturing our products.

The health  care  industry  is  unpredictable,  and  changes in the health  care
industry could adversely affect our business.

                                       6

<PAGE>

         The health care industry is subject to changing political, economic and
regulatory influences that may significantly affect the purchasing practices and
pricing of human therapeutics.  Cost containment measures, whether instituted by
health care providers or enacted as a result of government health administration
regulators  or new  regulations,  such as  pricing  limitations  or  formulating
eligibility  for  dispensation  by medical  providers,  could  result in greater
selectivity in the availability of treatments.  Such  selectivity  could have an
adverse effect on Cellegy's ability to sell prescription  products, and adequate
patient  insurance  coverage may not be available for Cellegy to maintain  price
levels.  The trend towards managed health care in the United States,  as well as
legislative  proposals  to reform  health  care or reduce  government  insurance
programs,  may result in lower prices or reduced markets for Cellegy's products.
The  adoption  of any such  measures  or reforms  could have a material  adverse
effect  on  the  business  and   financial   condition  of  Cellegy.   Moreover,
cosmeceutical products generally are not reimbursed by third party payors.

We have  very  limited  staffing  and will  continue  to be  dependent  upon key
employees.

         Our  success is  dependent  upon the efforts of a small  technical  and
management  team.  If key  individuals  leave  Cellegy,  we could  be  adversely
affected if suitable replacement personnel are not quickly recruited. Our future
success  depends  upon our ability to  continue to attract and retain  qualified
scientific,  marketing and technical personnel. There is intense competition for
qualified  personnel  in all  functional  areas  and  competition  will  make it
difficult  to attract  and  retain the  qualified  personnel  necessary  for the
development and growth of our business.

We are subject to the risk of product liability lawsuits.

         The testing,  marketing and sale of human health care products  entails
an inherent risk of allegations of product liability. We are subject to the risk
that  substantial  product  liability claims could be asserted against us in the
future.  Cellegy  has  obtained  limited  amounts of  insurance  relating to our
clinical  trials.  There can be no assurance that Cellegy will be able to obtain
or maintain insurance on acceptable terms for clinical and commercial activities
or  that  any  insurance  obtained  will  provide  adequate  protection  against
potential liabilities.

Our stock price could be volatile.

         Our stock price has from time to time experienced significant price and
volume   fluctuations   that  may  be  unrelated   to   operating   performance.
Announcements that could significantly impact our stock price include:

     o   clinical trial results;

     o   developments or disputes concerning patent or proprietary rights;

     o   publicity  regarding  actual or potential  clinical results relating to
         our products under development or by our competitors;

     o   regulatory   developments   in  both  the  United  States  and  foreign
         countries;

     o   sales of a large number of shares of common stock in the market;

     o   economic and other external factors; and,

     o   period-to-period fluctuations in financial results.

Our quarterly operating results are subject to fluctuations,  which could affect
our stock price.

         Given the uncertain nature of drug development,  it is difficult for us
to predict  operating  expenses  and  revenues  from  period to  period.  If our
products are approved,  it will be very difficult to predict the  sustainability
of initial prescription  patterns and resulting revenues of our products.  These
potential  fluctuations  in financial  results may  negatively  impact our stock
price.


                                 USE OF PROCEEDS

         If the  warrants  described  under  "Selling  Stockholders"  below  are
exercised  for cash,  then we would  receive the proceeds  from  exercise of the
warrants.  However, we will not receive any proceeds from the sale of the common
stock by any of the selling stockholders.


                                       7

<PAGE>

                              SELLING STOCKHOLDERS

         We are registering  the shares of common stock (the "Shares")  pursuant
to (i) a  Common  Stock  Purchase  Agreement  dated  as of July  30,  1999  (the
"Agreement"),  by and among  Cellegy  and the selling  stockholders  named below
other than Dr. Crowley and Dr. Bank, (ii) a common stock purchase  warrant dated
January 18, 1999  between  Cellegy and Michael P.  Crowley,  Ph.D.,  and (iii) a
common stock purchase warrant dated January 19, 1999 between Cellegy and Richard
Bank,  M.D. The warrant held by Dr. Crowley is  exercisable  until July 2, 2000,
and 2,000 warrants have an exercise price of $4.6875 per share. The warrant held
by Dr. Bank is  exercisable  until January 19, 2001 and has an exercise price of
$4.00 per share. The warrants were issued in consideration of services  provided
by Dr. Crowley and Dr. Bank to Cellegy.
<TABLE>
         The following table sets forth  information with respect to the selling
stockholders  and the shares of the common stock that may be offered pursuant to
this prospectus. Except as provided below, none of the selling stockholders has,
or within the past three years has had, any position,  office or other  material
relationship with us or any of our predecessors or affiliates.

         Each  selling  shareholder  represented  to  us,  in  their  respective
agreements,  that they were  purchasing  such Shares for  investment and with no
present  intention  of  distributing  or  reselling  such  Shares.  However,  in
recognition of the fact that each such stockholder,  even though purchasing such
Shares for  investment,  wishes to be legally  permitted to sell the Shares when
they  deem  appropriate,   we  are  filing  this  registration  statement.  Upon
effectiveness, the selling stockholders may from time to time offer and sell any
or all of  their  Shares  pursuant  to  this  prospectus.  Because  the  selling
stockholders  are not  obligated  to sell  shares of common  stock,  and because
selling  Stockholders  may also  acquire  publicly  traded  shares of our common
stock,  we  cannot  estimate  how many  shares  of  common  stock  each  selling
stockholder will beneficially own after this offering.

<CAPTION>

                                             Shares of Common Stock                     Shares of Common Stock
                                             Beneficially Owned(1)       Number of      Beneficially Owned(1)
                                             Prior to the Offering        Shares          After the Offering
                                             ----------------------        Being        ----------------------
Name                                           Number      Percent        Offered        Number      Percent
- ----                                           ------      -------        -------        ------      -------
<S>                                          <C>            <C>           <C>         <C>             <C>
Four Partners                                3,104,300(2)   26.2%         720,000     2,384,300       23.3%
Bay Resource Partners, L.P.                    182,302       1.5%          40,000       142,302        1.4%
Bay Resource Partners Offshore Ltd.            105,900       0.9%          56,000        49,900        0.5%
Janus Global Life Sciences Fund                720,000       6.1%         720,000          --          0.0%
K. Michael Forrest(3)                          793,494       6.6%          25,000       768,494        7.4%
Michael P. Crowley, Ph.D.                        2,000       0.0%           2,000          --          0.0%
Richard Bank, M.D.                              12,000       0.1%          12,000          --          0.0%
<FN>
- ----------
(1)  Beneficial  ownership is  determined  in  accordance  with the rules of the
Securities and Exchange  Commission and generally  includes voting or investment
power with respect to securities.  Unless otherwise indicated below, the persons
and entities named in the table have sole voting and sole investment  power with
respect to all shares  beneficially  owned,  subject to community  property laws
where applicable.

(2) Consists of: (i) 725,000 shares of common stock owned by Four Partners; (ii)
47,700 shares of common stock owned by Four-Fourteen Partners LLC; (iii) 578,100
shares of common  stock  owned The Andrew H. Tisch  1999  Annuity  Trust I; (iv)
578,100  shares of common stock owned The Daniel R. Tisch 1999 Annuity  Trust I;
(v) 578,100  shares of common stock owned The James S. Tisch 1999 Annuity  Trust
I; (vi)  578,100  shares of common  stock owned The Thomas J. Tisch 1999 Annuity
Trust I; and  (vii)  19,200  shares of common  stock  held by James S.  Tisch as
custodian for his children. Four Partners is a New York general partnership, the
sole partners of which are Andrew H. Tisch 1991 Trust, for which Andrew H. Tisch
is the managing  trustee,  Daniel R. Tisch 1991 Trust, for which Daniel R. Tisch
is the managing trustee,  James S. Tisch 1991 Trust, for which James S. Tisch is
the managing trustee,  and Thomas J. Tisch 1991 Trust, for which Thomas J. Tisch
is the managing  trustee.  Four  Partners  might be deemed to be the  beneficial
owner of the shares of common  stock owned by the 1999  Annuity  Trusts I and by
James S. Tisch as custodian enumerated above.

(3) Mr. Forrest is the President and Chief Executive Officer of Cellegy.
</FN>
</TABLE>
         Cellegy has an agreement  that so long as Four Partners and persons and
entities  associated  with Four  Partners  and/or the Tisch  Family own at least
1,250,000  shares of Cellegy  common stock,  that Cellegy will,  upon request of
such  shareholders,  increase the authorized  number of the members of Cellegy's
Board of Directors and caused one designee of such  shareholders to be nominated
and elected to fill one such position on the Board of Directors.

                                       8

<PAGE>

                              PLAN OF DISTRIBUTION

         We have filed a Registration Statement of which this prospectus forms a
part  pursuant to  registration  rights we granted to the  selling  stockholders
pursuant to the Agreement.

         To  our  knowledge,   no  selling  stockholder  has  entered  into  any
agreement,  arrangement or  understanding  with any particular  broker or market
maker with respect to the shares of common stock offered hereby,  nor do we know
the identity of the brokers or market makers that will  participate  in the sale
of the  shares.  As used in this  prospectus,  the term  "selling  stockholders"
includes  donees and  pledgees  selling  shares  received  from a named  selling
stockholder after the date of this prospectus.

         Who  May  Sell;  How  Much;   Applicable   Restrictions.   The  selling
stockholders  may from time to time  offer the  shares of common  stock  through
brokers,  dealers  or  agents  who  may  receive  compensation  in the  form  of
discounts,  concessions or commissions from the selling  stockholders and/or the
purchasers  of the  shares  of common  stock for whom they may act as agent.  In
effecting sales, broker-dealers that are engaged by the selling stockholders may
arrange for other  broker-dealers to participate.  The selling  stockholders and
any such brokers,  dealers or agents who participate in the  distribution of the
shares of common  stock may be deemed to be  "underwriters,"  and any profits on
the sale of the shares of common stock by them and any discounts, commissions or
concessions  received by any such brokers,  dealers or agents might be deemed to
be  underwriting  discounts and  commissions  under the  Securities  Act. To the
extent the selling  stockholders may be deemed to be  underwriters,  the selling
stockholders may be subject to certain  statutory  liabilities of, including but
not  limited to,  Sections  11, 12 and 17 of the  Securities  Act and Rule 10b-5
under  the  Exchange  Act.  To our  knowledge,  there  are  currently  no plans,
arrangements or understandings  between any selling stockholders and any broker,
dealer, agent or underwriter regarding the sale of the shares of common stock by
the selling stockholders.

         Manner of Sales and Applicable  Restrictions.  The selling stockholders
will act  independently  of  Cellegy  in making  decisions  with  respect to the
timing,  manner  and size of each  sale.  Such sales may be made over the Nasdaq
Stock Market or otherwise,  at then prevailing  market prices, at prices related
to prevailing market prices or at negotiated  prices. The shares of common stock
may be sold according to one or more of the following methods:

         (a)   a block  trade in which the  broker or  dealer  so  engaged  will
               attempt  to sell the  shares  of  common  stock as agent  but may
               position  and  resell a  portion  of the  block as  principal  to
               facilitate the transaction;

         (b)   purchases by a broker or dealer as  principal  and resale by such
               broker or dealer for its account pursuant to this prospectus;

         (c)   an  over-the-counter  distribution  in accordance with the Nasdaq
               rules;

         (d)   ordinary  brokerage  transactions  and  transactions in which the
               broker solicits purchasers;

         (e)   privately negotiated transactions.

         A selling  stockholder  may  decide not to sell any  shares.  We cannot
assure you that any selling  stockholder will use this prospectus to sell any or
all of the shares.  Any shares covered by this prospectus which qualify for sale
pursuant to Rule 144 or Rule 144A of the  Securities  Act 1933 may be sold under
Rule 144 or Rule 144A rather than pursuant to this  prospectus.  In addition,  a
selling  stockholder may transfer,  devise or gift the shares by other means not
described in this prospectus.

         Certain   persons   participating   in  this  offering  may  engage  in
transactions  that  stabilize,  maintain  or  otherwise  affect the price of our
common stock,  including  the entry of  stabilizing  bids or syndicate  covering
transactions or the imposition of penalty bids. The selling stockholders and any
other person  participating in such  distribution  will be subject to applicable
provisions  of the  Exchange  Act  and  the  rules  and  regulations  thereunder
including,  without  limitation,  Regulation M (which  regulation  may limit the
timing  of  purchases  and sales of any of the  shares  of  common  stock by the
selling  stockholders and any other such person).  The  anti-manipulation  rules
under the  Exchange  Act may  apply to sales of  shares  of common  stock in the
market and to the activities of the selling  stockholders and their  affiliates.
Furthermore,  Regulation  M of the  Exchange Act may restrict the ability of any
person  engaged in the  distribution  of the shares of common stock to engage in
market-making  activities with respect to the particular  shares of common stock
being  distributed  for a  period  of up to  five  business  days  prior  to the
commencement  of  such  distribution.  All  of  the  foregoing

                                       9

<PAGE>

may affect the  marketability  of the shares of common  stock and the ability of
any person or entity to engage in  market-making  activities with respect to the
shares of common stock.

         Rules 101 and 102 of Regulation M under the Exchange  Act,  among other
things,  generally prohibit certain  participants in a distribution from bidding
for or  purchasing  for an account  in which the  participant  has a  beneficial
interest,  any of the securities that are the subject of the distribution.  Rule
104 of Regulation M governs bids and purchases  made to stabilize the price of a
security in connection with a distribution of the security.

         Hedging  and  Other  Certain  Transactions  with   Broker-Dealers.   In
connection with  distributions  of the shares of common stock or otherwise,  the
selling stockholders may enter into hedging transactions with broker-dealers. In
connection with such  transactions,  broker-dealers may engage in short sales of
the shares of common  stock  registered  hereunder  in the course of hedging the
positions they assume with selling  stockholders.  The selling  stockholders may
also sell shares of common stock short and  redeliver the shares of common stock
to close out such short positions.  The selling stockholders may also enter into
option or other transactions with  broker-dealers  which require the delivery to
the broker-dealer of the shares of common stock registered hereunder,  which the
broker-dealer  may resell or  otherwise  transfer  pursuant to this  prospectus.
Selling  stockholders  may also  loan or  pledge  the  shares  of  common  stock
registered  hereunder  to a  broker-dealer  and the  broker-dealer  may sell the
shares of common  stock so loaned or,  upon a  default,  the  broker-dealer  may
effect sales of the pledged shares of common stock pursuant to this prospectus.

         Expenses  Associated  With  Registration.  We  have  agreed  to pay the
expenses of  registering  the shares of common stock under the  Securities  Act,
including  registration  and  filing  fees,  printing  expenses,  administrative
expenses and certain legal and accounting fees. Each of the selling stockholders
will bear its pro rata  share of all  discounts,  commissions  or other  amounts
payable to underwriters, dealers or agents as well as fees and disbursements for
legal counsel retained by any such selling stockholder.

         Indemnification.  Under the terms of the  Agreement,  we have agreed to
indemnify each of the parties to the Agreement and certain other persons against
certain  liabilities  in  connection  with the  offering of the shares of common
stock, including liabilities arising under the Securities Act.

         Prospectus  Updates;  Suspension  of  this  Offering.  At  any  time  a
particular offer of the shares of common stock is made, a revised  prospectus or
prospectus  supplement,  if  required,  will  be  distributed.  Such  prospectus
supplement or post-effective amendment will be filed with the SEC to reflect the
disclosure of required  additional  information with respect to the distribution
of the  shares of common  stock.  Under  the  terms of the  Agreement,  upon the
occurrence  of any event  known to our  executive  officers as a result of which
this  prospectus  is  known by our  executive  officers  to  include  an  untrue
statement of a material  fact or omits to state a material  fact  required to be
stated therein or necessary to make the statements therein not misleading in the
light of the  circumstances  then existing,  the parties have each agreed not to
trade  shares of common  stock from the time the  selling  stockholder  receives
notice  from  Cellegy of such an event  until such party  receives a  prospectus
supplement or  amendment.  Upon the  occurrence  of such an event,  a prospectus
supplement or post-effective  amendment, if required, will be distributed to the
parties.

                      WHERE YOU CAN FIND MORE INFORMATION

         We are  subject to the  informational  requirements  of the  Securities
Exchange Act and, in accordance therewith, we file reports and other information
with the Securities and Exchange Commission.  Reports,  registration statements,
proxy and information  statements,  and other information that we have filed can
be inspected and copied at the public reference facilities maintained by the SEC
at Room 1024, 450 Fifth Street,  N.W.,  Washington,  D.C.  20549, as well as the
regional offices of the SEC located at Citicorp Center, 500 West Madison Street,
Suite 1400, Chicago,  Illinois 60661, and Seven World Trade Center,  Suite 1300,
New York, New York 10048. You may obtain copies of such material from the Public
Reference Section of the SEC at 450 Fifth Street, N.W.,  Washington,  D.C. 20549
at rates  prescribed  by the SEC.  The  public  may  obtain  information  on the
operation of the Public Reference Room by calling the SEC at 1-800-SEC-0330. The
SEC also  maintains  a World  Wide Web site  that  contains  reports,  proxy and
information statements,  and other information that is filed electronically with
the SEC. This Web site can be accessed at  http://www.sec.gov.  Our common stock
is listed on the Nasdaq  Stock Market and reports,  proxy  statements  and other
information  concerning  Cellegy may be inspected at the offices of the National
Association  of  Securities  Dealers,  Inc.,  9513 Key West  Avenue,  Rockville,
Maryland 20850.

                                       10

<PAGE>

         We  have  filed  with  the SEC a  registration  statement  on Form  S-3
(together  with  all  amendments  and  exhibits   thereto,   the   "Registration
Statement")  under the  Securities  Act with respect to the common stock offered
hereby. This prospectus does not contain all of the information set forth in the
Registration  Statement and its exhibits and  schedules,  certain parts of which
are omitted in accordance with the rules and regulations of the SEC. For further
information  with  respect  to us and our  common  stock,  please  refer  to the
Registration  Statement and its exhibits and schedules.  Statements contained in
this  prospectus  as to the contents of any  contract or other  document are not
necessarily  complete  and, in each  instance,  reference is made to the copy of
such  contract or document  filed as an exhibit to the  Registration  Statement.
Each such  statement is qualified in all respects by such  reference.  Copies of
the Registration Statement, including exhibits thereto, may be inspected without
charge at the SEC's  principal  office in  Washington,  D.C., and you may obtain
copies from this office upon payment of the fees prescribed by the SEC.

         We will furnish without charge to each person, including any beneficial
owner,  to whom a copy of this  prospectus  is  delivered,  upon  such  person's
written or oral request,  a copy of any and all of the information that has been
incorporated  by reference  into this  prospectus  (other than  exhibits to such
documents,  unless such  exhibits  are  specifically  incorporated  by reference
herein as well).  Requests  for such copies  should be  directed  to A.  Richard
Juelis, our Chief Financial Officer, at (650) 616-2200.

                       DOCUMENTS INCORPORATED BY REFERENCE

         The  following   documents   that  we  have  filed  with  the  SEC  are
incorporated by reference into this prospectus:

         (a)   the  Registration  Statement and the exhibits and schedules filed
               therewith.

         (b)   our annual report on Form 10-K for the fiscal year ended December
               31, 1998.

         (c)   all other reports filed pursuant to Section 13(a) or 15(d) of the
               Exchange  Act  since  December  31,  1998,  including:   (1)  our
               quarterly  reports  on Form 10-Q for the  fiscal  quarters  ended
               March 31, 1999 and June 30, 1999; and (2) our Proxy  Statement on
               Form DEF 14A filed on April 14, 1999.

         (d)   all  other  information  that we file  with the SEC  pursuant  to
               Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act subsequent
               to the date of this  prospectus  and prior to the  termination of
               this offering.

         (e)   our Report on Form 8-K filed on August 18, l999.

         Any  statement  incorporated  herein  shall be deemed to be modified or
superseded for the purposes of this prospectus and the Registration Statement to
the extent that a statement  contained herein or in any other subsequently filed
document that is or is deemed to be incorporated by reference herein modifies or
supersedes  such statement.  Any such statement so modified or superseded  shall
not be deemed, except as so modified or superseded, to constitute a part of this
prospectus and the Registration Statement.

                                  LEGAL MATTERS

     The validity of the issuance of the shares of common stock  offered  hereby
will be passed upon for us by Fenwick & West LLP, our counsel.

                                     EXPERTS

     Ernst &  Young  LLP,  independent  auditors,  have  audited  our  financial
statements  included  in our  Annual  Report  on Form  10-K for the  year  ended
December  31,  1998,  as set forth in their  report,  which is  incorporated  by
reference in this prospectus and elsewhere in the  registration  statement.  Our
financial  statements are incorporated by reference in reliance on Ernst & Young
LLP's report given on their authority as experts in accounting and auditing.

                                       11

<PAGE>

================================================================================






                          CELLEGY PHARMACEUTICALS, INC.







                        1,575,000 Shares of Common Stock







                              --------------------

                                   PROSPECTUS

                              --------------------




================================================================================


<PAGE>

                                     PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 14.  OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION.

The estimated  expenses to be paid by the  Registrant  in  connection  with this
offering are as follows:

NASDAQ Stock Market Fee                                         $17,500.00
Securities and Exchange Commission registration fee             $ 3,078.64
Accounting fees and expenses                                    $ 4,000.00
Legal fees and expenses                                         $10,000.00
Miscellaneous                                                   $25,000.00
                                                                ----------
Total                                                           $59,578.64
                                                                ==========


ITEM 15.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.

         The Registrant's  Amended and Restated  Articles of Incorporation  (the
"Restated  Articles") include a provision that eliminates the personal liability
of its directors to the Registrant and its shareholders for monetary damages for
breach of the directors'  fiduciary duties to the maximum extent permitted under
California law. This limitation has no effect on a director's  liability (i) for
acts or omissions that involve intentional  misconduct or a knowing and culpable
violation  of law,  (ii) for acts or  omissions  that a director  believes to be
contrary to the best  interests of the  Registrant or its  shareholders  or that
involve  the  absence of good faith on the part of the  director,  (iii) for any
transaction from which a director derived an improper personal benefit, (iv) for
acts or omissions that show a reckless  disregard for the director's duty to the
Registrant or its shareholders in circumstances in which the director was aware,
or should have been aware,  in the  ordinary  course of  performing a director's
duties, of a risk of a serious injury to the Registrant or its shareholders, (v)
for acts or omissions that constitute an unexcused  pattern of inattention  that
amounts  to an  abdication  of the  director's  duty  to the  Registrant  or its
shareholders,  (vi) under Section 310 of the California  Corporations  Code (the
"California Code") (concerning  contracts or transactions between the Registrant
and a director) or (vii) under Section 316 of the  California  Code  (concerning
directors'  liability  for  improper  dividends,  loans  and  guarantees).   The
provision  does not extend to acts or omissions of a director in his capacity as
an officer. Further, the provision has no effect on claims arising under federal
or state securities laws and will not affect the availability of injunctions and
other equitable  remedies  available to the  Registrant's  shareholders  for any
violation of a director's fiduciary duty to the Registrant or its shareholders.

         The Restated  Articles also include an authorization for the Registrant
to  indemnify  its agents (as  defined in Section 317 of the  California  Code),
through  bylaws  provisions,  by agreement or otherwise,  to the fullest  extent
permitted by law.  Pursuant to this latter  provision,  the Registrant's  Bylaws
provide  for  indemnification  of  the  Registrant's  directors,   officers  and
employees.  Indemnification may only be authorized by a majority of Registrant's
directors  or  shareholders  or by order of a court,  unless  the agent has been
successful on the merits. In addition,  the Registrant's policy is to enter into
indemnification  agreements  with  each of its  officers  and  directors.  These
indemnification   agreements   provide  that  directors  and  officers  will  be
indemnified  and held  harmless to the fullest  extent  permitted by law.  These
agreements,  together with the Restated  Articles,  may require the  Registrant,
among other things, to indemnify such directors,  officers and employees against
certain  liabilities  that may  arise by reason of their  status or  service  as
directors or officers (other than liabilities  resulting from willful misconduct
of a  culpable  nature),  to  advance  expenses  to them as they  are  incurred,
provided  that they  undertake to repay the amount  advanced if it is ultimately
determined  by a court that they are not  entitled  to  indemnification,  and to
obtain directors' and officers' insurance if available on reasonable terms.

         Section  317  of  the   California   Code  makes   provisions  for  the
indemnification  of  officers,  directors  and other  corporate  agents in terms
sufficiently broad to indemnify such persons, under certain  circumstances,  for
liabilities  (including  reimbursement of expenses  incurred)  arising under the
Securities Act.

         The  Underwriting  Agreement  referred  to  below  sets  forth  certain
provisions  with respect to the  indemnification  of the  Registrant and certain
directors,   officers,  and  controlling  persons  against  certain  losses  and
liabilities, including certain liabilities under the Securities Act.

         The Amended and Restated  Registration Rights Agreement dated April 10,
1992,  entered into by and among the Registrant and various  investors,  and the
Amended and Restated  Registration  Rights  Agreement  dated  February 10, 1995,
entered into by and among the Registrant and various investors provide for cross
indemnification of certain holders of Registrant's securities, and of Registrant
and its  officers  and  directors  for certain  liabilities  existing  under the
Securities Act and otherwise.

                                       13

<PAGE>

         The Registrant also maintains a director and officer liability policy.

ITEM 16.  EXHIBITS.

The following exhibits are filed herewith or incorporated by reference herein:

4.1 - Common Stock Purchase Agreement dated as of July 30, 1999.

4.2 - Common Stock Purchase Warrant dated as of January 18, 1999

4.3 - Common Stock Purchase Warrant dated as of January 19, 1999

5.1 -- Opinion of Counsel regarding the legality of common stock.

23.1 -- Independent Auditors' Consent.

23.2 -- Consent of Counsel (included in Exhibit 5.1).

24.1 -- Power of Attorney (see page II-5).
- ---------------------------

ITEM 17.  UNDERTAKINGS.

Insofar as indemnification  for liabilities arising under the Securities Act may
be permitted to directors,  officers and  controlling  persons of the Registrant
pursuant to the  provisions  described  under Item 15 above,  or otherwise,  the
Registrant  has been advised that in the opinion of the  Securities and Exchange
Commission  such  indemnification  is against  public policy as expressed in the
Securities Act and is, therefore,  unenforceable.  In the event that a claim for
indemnification  against  such  liabilities  (other  than  the  payment  by  the
Registrant of expenses  incurred or paid by a director,  officer or  controlling
person of the  Registrant  in the  successful  defense  of any  action,  suit or
proceeding)  is  asserted by such  director,  officer or  controlling  person in
connection with the securities being registered,  the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit  to a  court  of  appropriate  jurisdiction  the  question  whether  such
indemnification  by it is against  public policy as expressed in the  Securities
Act and will be governed by the final adjudication of such issue.

The undersigned Registrant hereby undertakes:

(1) To file,  during  any  period in which  offers or sales  are being  made,  a
post-effective  amendment  to this  Registration  Statement:  (i) to include any
prospectus  required  by Section  10(a)(3)  of the  Securities  Act of 1933 (the
"Securities Act"); (ii) to reflect in the prospectus any facts or events arising
after the  effective  date of the  Registration  Statement  (or the most  recent
post-effective  amendment  thereof)  which,  individually  or in the  aggregate,
represent a fundamental change in the information in the Registration Statement;
and (iii) to  include  any  material  information  with  respect  to the plan of
distribution  not  previously  disclosed  in the  Registration  Statement or any
material change to such  information in the  Registration  Statement;  provided,
however,  that  (i) and  (ii) do not  apply if the  information  required  to be
included in a post-effective  amendment thereby is contained in periodic reports
filed  by  the  Registrant  pursuant  to  Section  13 or  Section  15(d)  of the
Securities  Exchange Act of 1934 (the "Exchange  Act") that are  incorporated by
reference in the Registration Statement.

(2) That, for the purpose of determining any liability under the Securities Act,
each such  post-effective  amendment  shall be  deemed to be a new  registration
statement relating to the securities  offered therein,  and the offering of such
securities  at that time shall be deemed to be the  initial  bona fide  offering
thereof.

(3) To remove from  registration by means of a  post-effective  amendment any of
the securities  being  registered  which remain unsold at the termination of the
offering.

(4) That, for purposes of determining  any liability  under the Securities  Act,
each filing of the  Registrant's  annual  report  pursuant  to Section  13(a) or
Section  15(d) of the  Exchange  Act that is  incorporated  by reference in this
Registration  Statement  shall  be  deemed  to be a new  Registration  Statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

                                       14

<PAGE>

                                   SIGNATURES

Pursuant to the  requirements  of the Securities  Act, the Registrant  certifies
that it has reasonable grounds to believe that it meets all for the requirements
for filing on Form S-3 and has duly caused  this  Registration  Statement  to be
signed on its behalf by the undersigned,  thereunto duly authorized, in the City
of South San Francisco, State of California, on the ___ day of ____, 1999.

                                         CELLEGY PHARMACEUTICALS, INC.

                                         By: ___________________________________
                                              K. Michael Forrest, CEO

                                POWER OF ATTORNEY

KNOW ALL BY THESE PRESENTS that each individual  whose  signature  appears below
constitutes and appoints K. Michael  Forrest and A Richard  Juelis,  and each of
them, his  attorneys-in-fact,  and agents,  each with the power of substitution,
for him and in his name, place and stead, in any and all capacities, to sign any
and all amendments  (including  post-effective  amendments) to this Registration
Statement,  and to sign any registration statement for the same offering covered
by this  Registration  Statement that is to be effective upon filing pursuant to
Rule 462(b) promulgated under the Securities Act of 1933, and all post-effective
amendments  thereto,  and to file the same,  with all  exhibits  thereto and all
documents in connection therewith,  with the Securities and Exchange Commission,
granting unto said  attorneys-in-fact  and agents,  and each of them, full power
and  authority  to do and  perform  each and every act and thing  requisite  and
necessary  to be done in and about the  premises,  as fully to all  intents  and
purposes as he might or could do in person,  hereby ratifying and confirming all
that  said  attorneys-in-fact  and  agents  or any  of  them,  or  his or  their
substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
<TABLE>
Pursuant to the requirements of the Securities Act, this Registration  Statement
has been  signed by the  following  persons in the  capacities  and on the dates
indicated.
<CAPTION>
           Signature                                          Title                            Date
           ---------                                          -----                            ----
<S>                                                    <C>                                   <C>
PRINCIPAL EXECUTIVE OFFICER:

________________________________
K. Michael Forrest                                     Chief Executive Officer               _____, 1999


PRINCIPAL FINANCIAL AND
ACCOUNTING OFFICER:

________________________________                       Vice President, Finance,
A. Richard Juelis                                      Chief Financial Officer,
                                                       and Secretary                         _____, 1999

DIRECTORS:

________________________________
Carl R. Thornfeldt, M.D.                               Chairman of the Board of Directors    _____, 1999


________________________________
Jack L. Bowman                                         Director                              _____, 1999


________________________________
Tobi B. Klar, M.D.                                     Director                              _____, 1999


                                                    15

<PAGE>

________________________________
Alan A. Steigrod                                       Director                              ______, 1999


________________________________
Larry J. Wells                                         Director                              ______, 1999


________________________________
Ronald J. Saldarini, Ph.D.                             Director                              ______, 1999

</TABLE>

                                                   16

<PAGE>

                                  EXHIBIT INDEX

Exhibit
Number                            Exhibit Title
- -------                           -------------

    4.1        Common Stock Purchase Agreement dated as of July 30, 1999.
    4.2        Common Stock Purchase Warrant dated January 18, 1999
    4.3        Common Stock Purchase Warrant dated January 19, 1999
    5.1        Opinion of Counsel regarding the legality of common stock
   23.1        Independent Auditors' Consent
   23.2        Consent of Counsel (included in Exhibit 5.1)
   24.1        Power of Attorney (see page II-5)



                          CELLEGY PHARMACEUTICALS, INC.
                         COMMON STOCK PURCHASE AGREEMENT


         THIS COMMON STOCK PURCHASE  AGREEMENT  (this  "Agreement")  is made and
entered into as of July 30, 1999 by and among Cellegy  Pharmaceuticals,  Inc., a
California  corporation (the "Company"),  and the parties listed on the Schedule
of Investors separately delivered to the Investors (the "Schedule of Investors")
(each  hereinafter  individually  referred to as an "Investor" and  collectively
referred to as the "Investors").

         1.     AGREEMENT TO PURCHASE AND SELL STOCK.

                1.1  Authorization.  As of the Closing  (as  defined  below) the
Company will have authorized the issuance,  pursuant to the terms and conditions
of this Agreement,  of up to 1,561,000  shares of the Company's Common Stock, no
par value (the "Common Stock").

                1.2 Agreement to Purchase and Sell.  The Company  agrees to sell
to each  Investor at the Closing,  and each Investor  agrees,  severally and not
jointly,  to purchase  from the Company at the Closing,  the number of shares of
Common Stock for the aggregate  price set forth beside such  Investor's  name on
the Schedule of Investors, at the price per share for such Investor set forth on
the  Schedule  of  Investors.  The  shares of Common  Stock  purchased  and sold
pursuant to this Agreement will be collectively  hereinafter  referred to as the
"Purchased Shares."

         2.     CLOSING.

                2.1 The Closing.  The purchase and sale of the Purchased  Shares
will take  place at the  offices of  Fenwick & West LLP,  Two Palo Alto  Square,
Suite 800, Palo Alto,  California,  at 11:00 a.m. Pacific Time, on July 30, 1999
or at such other time and place as the Company and  Investors who have agreed to
purchase a majority of the Purchased  Shares listed on the Schedule of Investors
mutually  agree upon (which time and place are referred to in this  Agreement as
the "Closing"),  provided that the closing may not be delayed for more than five
business days without the consent of all Investors.  At the Closing, the Company
will deliver to each Investor a certificate representing the number of Purchased
Shares  that such  Investor  has agreed to  purchase  hereunder  as shown on the
Schedule of Investors  against  delivery to the Company by such  Investor of the
full purchase price of such Purchased Shares, paid by (i) a check payable to the
Company's  order,  (ii)  wire  transfer  of funds to the  Company  or (iii)  any
combination of the foregoing.

         3.  REPRESENTATIONS  AND WARRANTIES OF THE COMPANY.  The Company hereby
represents and warrants to Investor that,  except as set forth in the Disclosure
Schedule and  Schedule of  Exceptions  (the  "Disclosure  Schedule")  separately
delivered by the Company to the Investors  (which  Disclosure  Schedule shall be
deemed to be  representations  and  warranties  to the  Investors by the Company
under this Section and to qualify each of the

<PAGE>

representations  and  warranties  set  forth  herein),  the  statements  in  the
following paragraphs of this Section 3 are all true and correct:

                  3.1 Organization, Good Standing and Qualification. The Company
is a corporation duly organized, validly existing and in good standing under the
laws of the  State of  California,  and has all  requisite  corporate  power and
authority  to conduct  its  business  as  currently  conducted.  The  Company is
qualified to do business as a foreign  corporation  in each  jurisdiction  where
failure to be so  qualified  could  reasonably  be  expected  to have a material
adverse  effect on the business,  assets,  financial  condition,  prospects,  or
results of  operations  or assets of the Company (the  "Business")  (such effect
referred to as a "Material Adverse Effect").

                  3.2   Capitalization.   Immediately  before  the  Closing  the
capitalization of the Company will consist of the following:

                           (a) Preferred Stock. A total of 5,000,000  authorized
shares of Preferred Stock, no par value per share (the "Preferred Stock"),  none
of which are issued and outstanding.

                           (b) Common Stock.  A total of  20,000,000  authorized
shares of Common Stock, of which approximately 10,177,063 shares were issued and
outstanding as of June 30, 1999.

                           (c) Options,  Warrants,  Reserved Shares. Except for:
(i) the approximately 1,657,400 shares of Common Stock issuable upon exercise of
options outstanding as of June 30, 1999, (iii)  approximately  34,000 additional
shares of Common Stock  reserved for issuance under the Company's 1995 Directors
Stock Option Plan, (iv) approximately  792,600 additional shares of Common Stock
reserved for issuance  under the Company's  1995 Equity  Incentive  Plan and (v)
warrants to purchase an aggregate of  approximately  1,573,000  shares of Common
Stock, there are not outstanding any options, warrants, rights or agreements for
the purchase or acquisition  from the Company of any shares of its capital stock
or any securities convertible into or ultimately exchangeable or exercisable for
any shares of the Company's capital stock.

                  3.3 Subsidiaries.  Except for Cellisis Pharmaceuticals,  Inc.,
which is not a  "significant  subsidiary"  as defined in Rule 1-02 of Regulation
S-X, the Company does not presently own or control, directly or indirectly,  any
interest  in  any  other   corporation,   partnership,   trust,  joint  venture,
association, or other entity.

                  3.4 Due Authorization;  No Violation.  All corporate action on
the part of the Company and its officers,  directors and shareholders  necessary
for the  authorization,  execution and delivery of, and the  performance  of all
obligations  of the  Company  under,  this  Agreement,  and  the  authorization,
issuance,  reservation for issuance and delivery of all of the Purchased  Shares
being sold under this  Agreement,  has been taken or will be taken  prior to the
Closing,  and this Agreement  constitutes a valid and legally binding obligation
of the Company,  enforceable  against the Company in accordance  with its terms,
except  as  enforceability   may  be  limited  by  (i)  applicable   bankruptcy,
insolvency,  reorganization or other laws of general application  relating to

                                       2

<PAGE>

or affecting the enforcement of creditors'  rights generally and (ii) the effect
of rules of law governing the  availability of equitable  remedies.  Neither the
execution,  delivery or  performance  by the Company of this  Agreement  nor the
consummation  by the Company of the  transactions  contemplated  hereby will (i)
conflict with or result in a breach of any provision of the Restated Articles of
Incorporation of the Company (the "Restated  Articles") or the Company's Bylaws,
(ii) conflict  with,  result in a violation or breach of, or cause a default (or
give rise to any right of termination,  cancellation or acceleration)  under any
of the terms, conditions or provisions of any material agreement,  instrument or
obligation to which the Company is a party,  which  default could  reasonably be
expected to have a Material  Adverse  Effect or (iii) violate any law,  statute,
rule or  regulation  or  judgment,  order,  writ,  injunction  or  decree of any
governmental authority, in each case applicable to the Company or its properties
or assets and which,  individually  or in the  aggregate,  could  reasonably  be
expected to have a Material Adverse Effect.

                  3.5  Valid  Issuance  of Stock.  The  Purchased  Shares,  when
issued,  sold and delivered in accordance  with the terms of this  Agreement for
the consideration  provided for herein,  will be duly and validly issued,  fully
paid and nonassessable and are not subject to preemptive or other similar rights
of any shareholder of the Company.

                  3.6  Governmental  Consents.  No consent,  approval,  order or
authorization of, or registration,  qualification,  designation,  declaration or
filing with, any federal,  state or local governmental  authority on the part of
the Company is required in connection  with the valid  execution and delivery of
this Agreement,  the offer,  sale and issuance of the Purchased  Shares,  or the
consummation of the  transactions  contemplated  by this  Agreement,  except for
qualifications  or filings  under the  Securities  Act of 1933,  as amended (the
"Act") and the applicable rules and regulations (the "Rules and Regulations") of
the Securities and Exchange Commission (the "Commission") under the Act, and all
other  applicable  securities  laws as may be  required in  connection  with the
transactions  contemplated  by this  Agreement.  All such  consents,  approvals,
orders,    authorizations,    registrations,    qualifications,    designations,
declarations  or filings will be effective on the Closing,  and all such filings
be made within the time prescribed by law.

                  3.7 Absence of Changes. After the respective dates as of which
information is given in the Company's  Proxy Statement for the annual meeting of
shareholders  held on May 20, 1999, the Company's Annual Report on Form 10-K for
the year ended  December 31, 1998, the Company's  Quarterly  Report on Form 10-Q
for the quarter ended March 31, 1999 respectively (such documents, together with
the  Disclosure   Schedule,   referred  to   collectively   as  the  "Disclosure
Documents"), there has not been (i) any material adverse change in the Business,
(ii) any  transaction  that is material to the  Company,  (iii) any  obligation,
direct or contingent,  that is material to the Company, incurred by the Company,
(iv) any change in the outstanding  indebtedness of the Company that is material
to the Company, (v) any dividend declared,  paid or made on the capital stock of
the Company or (vi) any loss or damage  (whether or not insured) to the property
of the Company which has been  sustained  which could  reasonably be expected to
have a Material Adverse Effect.

                  3.8 Litigation.  There is no action, suit, proceeding,  claim,
arbitration or investigation ("Action") pending (or, to the Company's knowledge,
currently threatened) against

                                       3

<PAGE>

the Company,  its activities,  properties or assets, which (i) might prevent the
consummation  of the  transactions  contemplated  hereby  or (ii)  if  adversely
resolved  against the Company  could  reasonably  be expected to have a Material
Adverse Effect.

                  3.9 Nasdaq Listing. The Common Stock is registered pursuant to
Section 12(g) of the Securities  Exchange Act of 1934, as amended (the "Exchange
Act"),  and is listed on the Nasdaq Stock Market (Nasdaq National  Market).  The
Company has not received any  notification  that the  Commission or the National
Association of Securities Dealers, Inc. is contemplating the termination of such
registration or listing.  Before the Shelf Registration Statement (as defined in
Section 7.2) is declared effective by the Commission,  the Purchased Shares will
have been approved for  quotation on the Nasdaq Stock Market,  subject to notice
of issuance.

                  3.10  Exchange Act Filings.  The Company has filed in a timely
manner all reports and other  information  required to be filed ("Filings") with
the Commission pursuant to the Exchange Act during the preceding twelve calendar
months. On their respective dates of filing,  the Filings complied as to form in
all  material  respects  with the  requirements  of the  Exchange  Act,  and the
published rules and regulations of the Commission promulgated thereunder. To the
Company's knowledge after reasonable investigation, on their respective dates of
filing,  the Filings did not include  any untrue  statement  of a material  fact
required to be stated  therein or necessary to make the statements  therein,  in
light of the  circumstances  in which they were made,  not  misleading,  and all
financial  statements  contained  in the Filings  fairly  present the  financial
position  of the  Company  on the dates of such  statements  and the  results of
operations for the periods covered thereby in accordance with generally accepted
accounting  principles  consistently applied throughout the periods involved and
prior  periods,  except as otherwise  indicated  in the notes to such  financial
statements.

                  3.11 Disclosure.  To the Company's  knowledge after reasonable
investigation,  the  representations  and warranties made by the Company in this
Agreement  (including the Disclosure Schedule) when read together do not contain
any untrue statement of a material fact and do not omit to state a material fact
necessary to make the statements herein as a whole not misleading.

                  3.12  Governmental  Permits,  Etc. The Company  possesses  all
licenses,  franchises,  governmental  approvals,  permits or other  governmental
authorizations (collectively, "Authorizations") relating to the operation of the
Business,  except for those Authorizations the failure of which to possess would
not,  separately or in the aggregate,  have a Material  Adverse  Effect.  To the
Company's knowledge after reasonable investigation, the Company is in compliance
with the terms of all Authorizations and all laws,  ordinances,  regulations and
decrees which to the Company's knowledge are applicable to the Business,  except
for such non-compliance  which does not, separately or in the aggregate,  have a
Material Adverse Effect.

                  3.13  Insurance.  The  Company is covered  by  insurance  with
companies  the  Company  believes  to be  responsible  and in such  amounts  and
covering  such  risks as it  believes  to be  adequate  for the  conduct  of its
Business  and the value of its  properties  and as is  customary  for

                                       4

<PAGE>

companies engaged in similar businesses in similar  industries.  The Company has
no  knowledge  that any such carrier has grounds or intends to cancel or fail to
renew such policies.

                  3.14 Intellectual  Property.  To the Company's knowledge after
reasonable  investigation,  the Company  owns or possesses  the patents,  patent
rights, licenses, inventions,  copyrights, know-how (including trade secrets and
other unpatented and/or  unpatentable  proprietary or confidential  information,
systems or  procedures)  and other rights or interests in items of  intellectual
property as are necessary for the operation of the Business  operated by it (the
"Patent and  Proprietary  Rights"),  except  where the failure to own or possess
such  rights  would not have a Material  Adverse  Effect;  the  Company  has not
received  notice of any  asserted  rights with  respect to any of the Patent and
Proprietary  Rights  which,  if  determined  unfavorably  with  respect  to  the
interests of the Company would have a Material  Adverse Effect;  and the Company
has not received notice or is otherwise aware of any infringement of or conflict
with asserted  rights of others with respect to any of the Patent or Proprietary
Rights,  which  infringement  or  conflict  (if the  subject of any  unfavorable
decision, ruling or finding),  individually or in the aggregate, would result in
a Material Adverse Effect.

         4.  REPRESENTATIONS,  WARRANTIES  AND CERTAIN  AGREEMENTS OF INVESTORS.
Each Investor  hereby  represents and warrants to, and agrees with, the Company,
that:

                  4.1  Authorization.  All  corporate  action on the part of the
Investor  and  its  officers,  directors  and  stockholders  necessary  for  the
authorization, execution and delivery of, and the performance of all obligations
of the Investor  under,  this Agreement has been taken or will be taken prior to
the  Closing,  and  this  Agreement  constitutes  a valid  and  legally  binding
obligation of the Investor,  enforceable against the Investor in accordance with
its terms, except as enforceability may be limited by (i) applicable bankruptcy,
insolvency,  reorganization or other laws of general application  relating to or
affecting the enforcement of creditors'  rights generally and (ii) the effect of
rules of law governing the availability of equitable remedies.

                  4.2  Purchase  for Own  Account.  The  Purchased  Shares to be
purchased by such Investor  hereunder  will be acquired for  investment for such
Investor's  own account,  not as a nominee or agent,  and not with a view to the
public resale or  distribution  thereof  within the meaning of the Act, and such
Investor has no present intention of selling,  granting any participation in, or
otherwise  distributing  the same.  If not an  individual,  such  Investor  also
represents  that such  Investor has not been formed for the specific  purpose of
acquiring Purchased Shares.

                  4.3  Disclosure  of  Information.  The Investor has received a
copy of the Disclosure  Documents and has received or has had full access to all
the  information  it  considers  necessary  or  appropriate  to make an informed
investment  decision with respect to the Purchased Shares to be purchased by the
Investor under this  Agreement.  Investor  further has had an opportunity to ask
questions  and  receive  answers  from  the  Company  regarding  the  terms  and
conditions  of the  offering of the  Purchased  Shares and to obtain  additional
information  (to the extent the  Company  possessed  such  information  or could
acquire it  without  unreasonable  effort

                                       5

<PAGE>

or expense) necessary to verify any information  furnished to the Investor or to
which the Investor had access. The foregoing, however, does not in any way limit
or modify the representations and warranties made by the Company in Section 3.

                  4.4 Investment Experience.  Such Investor understands that the
purchase of the Purchased Shares involves  substantial risk. Such Investor:  (i)
has  experience  as an investor in  securities  of companies in the  development
stage and acknowledges  that such Investor is able to fend for itself,  can bear
the economic risk of such Investor's  investment in the Purchased Shares and has
such  knowledge  and  experience  in  financial  or business  matters  that such
Investor is capable of evaluating the merits and risks of this investment in the
Purchased  Shares and  protecting  its own  interests  in  connection  with this
investment and/or (ii) has a preexisting personal or business  relationship with
the Company and certain of its officers,  directors or controlling  persons of a
nature and duration  that enables  such  Investor to be aware of the  character,
business acumen and financial circumstances of such persons.

                  4.5 Accredited  Investor Status.  Unless  otherwise  expressly
indicated on the Schedule of Investors to this  Agreement,  such  Investor is an
"accredited  investor" within the meaning of Regulation D promulgated  under the
Act.

                  4.6 Restricted Securities.  Such Investor understands that the
Purchased  Shares are  characterized  as "restricted  securities"  under the Act
inasmuch  as they are being  acquired  from the  Company  in a  transaction  not
involving a public offering and that under the Act and the Rules and Regulations
such securities may be resold without registration under the Act only in certain
limited  circumstances.  In this connection,  such Investor represents that such
Investor is familiar with Rule 144 of the Commission and  understands the resale
limitations  imposed thereby and by the Act. Such Investor  understands that the
Company is under no obligation to register any of the Purchased Shares except as
provided in Section 7 below.

                  4.7 Further  Limitations  on  Disposition.  Without in any way
limiting the  representations  set forth above, such Investor further agrees not
to make any disposition of all or any portion of the Purchased Shares unless and
until:

                           (a) there is then in effect a registration  statement
under the Act covering such proposed disposition and such disposition is made in
accordance with such  registration  statement and the provisions of Section 7 of
this Agreement; or

                           (b) (i) such Investor shall have notified the Company
of the  proposed  disposition  and  shall  have  furnished  the  Company  with a
statement of the circumstances  surrounding the proposed  disposition,  and (ii)
such Investor shall have furnished the Company,  at the expense of such Investor
or its transferee,  with an opinion of counsel,  reasonably  satisfactory to the
Company,  that such disposition will not require registration of such securities
under the Act.

                Notwithstanding  the provisions of paragraphs (a) and (b) above,
no such registration  statement or opinion of counsel shall be required: (i) for
any transfer of any Purchased  Shares in  compliance  with Rule 144 or Rule 144A
(except  that an opinion of counsel

                                       6

<PAGE>

may be required for other than routine Rule 144  transactions),  or (ii) for any
transfer  of  Purchased  Shares  by  an  Investor  that  is a  partnership  or a
corporation  to (A) a  partner  of  such  partnership  or  shareholder  of  such
corporation,  or (B) the estate of any such partner or shareholder, or (iii) for
the transfer by gift, will or intestate succession by any Investor to his or her
spouse or lineal descendants or ancestors or any trust for any of the foregoing;
provided,  that in each of the foregoing cases the transferee  agrees in writing
to be subject to the terms of this  Section 4 (other  than  Section  4.5) to the
same extent as if the transferee were an original Investor hereunder.

                  4.8 Legends. It is understood that the certificates evidencing
the Purchased Shares will bear the legends set forth below:

                           (a) THE SECURITIES  REPRESENTED  HEREBY HAVE NOT BEEN
REGISTERED  UNDER THE SECURITIES  ACT OF 1933, AS AMENDED (THE "ACT"),  OR UNDER
THE  SECURITIES  LAWS  OF  CERTAIN  STATES.  THESE  SECURITIES  ARE  SUBJECT  TO
RESTRICTIONS ON TRANSFERABILITY  AND RESALE AND MAY NOT BE TRANSFERRED OR RESOLD
EXCEPT AS PERMITTED  UNDER THE ACT AND THE  APPLICABLE  STATE  SECURITIES  LAWS,
PURSUANT TO REGISTRATION OR EXEMPTION THEREFROM.  INVESTORS SHOULD BE AWARE THAT
THEY MAY BE  REQUIRED  TO BEAR THE  FINANCIAL  RISKS OF THIS  INVESTMENT  FOR AN
INDEFINITE PERIOD OF TIME. THE ISSUER OF THESE SECURITIES MAY REQUIRE AN OPINION
OF COUNSEL IN FORM AND SUBSTANCE  SATISFACTORY  TO THE ISSUER TO THE EFFECT THAT
ANY PROPOSED TRANSFER OR RESALE IS IN COMPLIANCE WITH THE ACT AND ANY APPLICABLE
STATE SECURITIES LAWS.

                           (b) THE  SHARES  EVIDENCED  BY THIS  CERTIFICATE  ARE
SUBJECT TO THE PROVISIONS OF, AND MAY HAVE CERTAIN  REGISTRATION RIGHTS PURSUANT
TO, THE PROVISIONS OF A PURCHASE  AGREEMENT  BETWEEN THE COMPANY AND THE HOLDER,
WHICH MAY RESTRICT THE TRANSFER OF SUCH SHARES IN CERTAIN CIRCUMSTANCES.  A COPY
OF SUCH AGREEMENT MAY BE OBTAINED,  WITHOUT CHARGE,  AT THE COMPANY'S  PRINCIPAL
OFFICE.

                           (c) After consultation with counsel for the Investor,
any legend that counsel to the Company  reasonably deems  appropriate  under the
laws of the State of California.

         The  legends  set forth in (a) and (b) above  shall be  removed  by the
Company from any certificate  evidencing  Purchased  Shares upon delivery to the
Company of an opinion of counsel to the Investor, reasonably satisfactory to the
Company,  that the legended security can be freely  transferred in a public sale
without a registration statement being in effect under the Act and in compliance
with exemption requirements under applicable state securities laws and that such
transfer  will not  jeopardize  the exemption or  exemptions  from  registration
pursuant to which the Company issued the Purchased Shares.

                  4.9  Resale  Restrictions.  To  the  extent  requested  by the
Company or an underwriter or placement agent of securities of the Company,  each
Investor agrees that it will not

                                       7

<PAGE>

directly or indirectly offer, sell, contract or grant an option to sell, pledge,
encumber,  or otherwise dispose of or otherwise  transfer (a "Disposition")  any
Purchased Shares (other than to donees, shareholders or partners of the Investor
who agree to be similarly bound) for up to 90 days after the effective date of a
registration  statement of the Company filed under the Act;  provided,  however,
that (i) this paragraph shall be applicable only to the first such  registration
statement  of the  Company  filed after the date of this  Agreement  that covers
securities  to be sold on its behalf to the public in an  underwritten  offering
and (ii) all executive officers and directors of the Company then holding Common
Stock who  beneficially  own more than one percent of the outstanding  shares of
Common Stock enter into similar  agreements.  This paragraph  shall not preclude
Investor from including Registrable  Securities in, and selling such Registrable
Securities pursuant to, such registration statement.

         5.       CONDITIONS TO INVESTOR'S OBLIGATIONS AT CLOSING.

                  5.1 Closing.  The obligations of each Investor under Section 2
of this Agreement to purchase the Purchased Shares at the Closing are subject to
the  fulfillment or waiver,  on or before the Closing,  of each of the following
conditions,  and the  Company  shall use all  reasonable  efforts  to cause such
conditions to be satisfied on or before the Closing:

                           5.1.1  Representations  and Warranties  True. Each of
the  representations  and warranties of the Company contained in Section 3 shall
be true and correct on and as of the Closing with the same effect as though such
representations and warranties had been made on and as of the Closing.

                           5.1.2  Performance.  The Company shall have performed
and complied with all agreements,  obligations and conditions  contained in this
Agreement  that are required to be performed or complied with by it on or before
the Closing and shall have obtained all approvals,  consents and  qualifications
necessary to complete the purchase and sale described herein.

                           5.1.3 Compliance Certificate.  The Company shall have
delivered to the Investors at the Closing a certificate  signed on its behalf by
its President,  Chief Executive  Officer,  or Chief Financial Officer certifying
that the conditions specified in Sections 5.1.1 and 5.1.2 have been fulfilled.

                           5.1.4 Registration;  Securities Exemptions. The offer
and sale of the  Purchased  Shares to the Investors  pursuant to this  Agreement
shall  be  exempt  from  the  registration  requirements  under  the Act and the
California  Corporate  Securities  Law  of  1968,  as  amended,  and  the  rules
thereunder (the "Law") and the registration and/or qualification requirements of
all other applicable state securities laws.

                           5.1.5  Proceedings  and Documents.  All corporate and
other  proceedings  in  connection  with the  transactions  contemplated  at the
Closing and all documents  incident thereto shall be reasonably  satisfactory in
form and substance to the Investor and to special counsel to the Investors,  and
they shall each have received all such documents as they may reasonably request.

                                       8

<PAGE>

                           5.1.6 No  Material  Change.  There shall have been no
material adverse change in the Business from the date of this Agreement.

                           5.1.7 Opinion of Counsel.  The  Investors  shall have
received  an  opinion of counsel  to the  Company  substantially  in the form of
Exhibit B attached hereto.

         6.       CONDITIONS TO THE COMPANY'S OBLIGATIONS AT CLOSING.

                  6.1.  Closing.  The  obligations  of the  Company  under  this
Agreement  to sell the  Purchased  Shares to the  Investors  at the  Closing are
subject to the  fulfillment  or waiver on or before  the  Closing of each of the
following conditions by the Investor, and each Investor shall use all reasonable
efforts to cause such conditions to be satisfied on or before the Closing:

                           6.1.1    Representations    and    Warranties.    The
representations  and warranties of the Investor  contained in Section 4 shall be
true and  correct on and as of the  Closing  with the same effect as though such
representations and warranties had been made on and as of the Closing.

                           6.1.2 Payment of Purchase  Price.  The Investor shall
have  delivered  to the  Company the  purchase  price for the  Purchased  Shares
specified for such  Investor on the Schedule of Investors  attached  hereto,  in
accordance with the provisions of Section 2.

                           6.1.3 Registration;  Securities Exemptions. The offer
and sale of the  Purchased  Shares to the  Investor  pursuant to this  Agreement
shall be exempt from the  registration  requirements  under the Act and shall be
exempt  from  the  qualification  requirements  of the Law and the  registration
and/or qualification requirements of all other applicable state securities laws.

                           6.1.4  Proceedings  and Documents.  All corporate and
other  proceedings  in  connection  with the  transactions  contemplated  at the
Closing and all documents  incident thereto shall be reasonably  satisfactory in
form and substance to the Company and to the Company's  legal  counsel,  and the
Company shall have received such documents as it may reasonably request.

         7.       REGISTRATION RIGHTS.

                  7.1      Definitions.  For purposes of this Agreement:

                           (a) Form S-3.  The term  "Form  S-3"  means such form
under the Act as is in effect on the date hereof or any  successor  registration
form  under  the  Act  subsequently  adopted  by the  Commission  which  permits
inclusion or  incorporation  of  substantial  information  by reference to other
documents filed by the Company with the Commission.

                           (b) Holder.  The term "Holders" shall mean holders of
Registrable Securities that have registration rights pursuant to this Agreement.

                                       9

<PAGE>

                           (c) Registration. The terms "register," "registered,"
and  "registration"  refer to a registration  effected by preparing and filing a
registration  statement  in  compliance  with the Act,  and the  declaration  or
ordering of effectiveness of such registration statement.

                           (d)  Registrable  Securities.  The term  "Registrable
Securities" means: (1) all of the Purchased Shares, and (2) any shares of Common
Stock of the Company issued as a dividend or other distribution with respect to,
or in exchange for or in replacement of, any of the Purchased Shares;  provided,
however, that the term "Registrable Securities" shall exclude in all events (and
such  securities  shall  not  constitute   "Registrable   Securities")  (i)  any
Registrable Securities sold or transferred by a person in a transaction in which
the  registration  rights  granted  under this  Agreement  are not  assigned  in
accordance  with  the  provisions  of  this  Agreement,   (ii)  any  Registrable
Securities sold in a public offering pursuant to a registration  statement filed
with the  Commission  or sold  pursuant  to Rule 144  promulgated  under the Act
("Rule 144") or (iii) as to any Holder, the Registrable  Securities held by such
Holder if all of such Registrable Securities can be publicly sold without volume
restriction within a three-month period pursuant to Rule 144.

                           (e) Prospectus:  The term "Prospectus" shall mean the
prospectus  included in any Shelf  Registration  Statement  (including,  without
limitation,  a prospectus that discloses  information  previously omitted from a
prospectus filed as part of an effective registration statement in reliance upon
Rule  430A  promulgated  under the  Act),  as  amended  or  supplemented  by any
prospectus supplement (including,  without limitation, any prospectus supplement
with  respect to the terms of the  offering  of any  portion of the  Registrable
Securities  covered  by  such  Shelf  Registration  Statement),  and  all  other
amendments  and   supplements  to  the  Prospectus,   including   post-effective
amendments,  and  all  material  incorporated  by  reference  or  deemed  to  be
incorporated by reference in such Prospectus.

                           (f) Shelf Registration Statement. See Section 7.2(a).

                  7.2      Form S-3 Shelf Registration.

                           (a) Registration.  The Company shall prepare and file
with the Commission  within 60 days following the Closing and use all reasonable
efforts  to  have  declared  effective  as  soon as  practicable  thereafter,  a
registration  statement on Form S-3 (or, if the Company is not then  eligible to
use Form S-3,  then another  appropriate  form)  providing for the resale by the
Holders  of  all  of  the  Registrable   Securities  (the  "Shelf   Registration
Statement").  The Shelf Registration Statement may include securities other than
those held by  Holders.  If the Shelf  Registration  Statement  is not  declared
effective by December 31, 1999 and does not remain  effective  for 45 continuous
days after its effective date (except for any permitted closing of the Permitted
Window as described in Section  7.2(b)(c)  below),  then the  Investors  holding
Registrable  Securities  shall be entitled to receive from the Company (pro rata
in  accordance  with their  ownership of  Registrable  Securities)  an aggregate
number of shares of Common Stock equal to 1% of the number of  Purchased  Shares
for each month after November 30, 1999, that the Shelf Registration Statement is
not declared effective (or does not remain effective), up to a

                                       10

<PAGE>

maximum  aggregate amount of 5% of the Purchased  Shares.  The Company shall use
its  best  efforts  to  keep  the  Shelf  Registration   Statement  continuously
effective,  pursuant  to the Act  and  the  Rules  and  Regulations  promulgated
thereunder,  until (i) the date when such  Registrable  Securities cease to meet
the  definition of Registrable  Securities  pursuant to Section 7.1, or (ii) the
Company's obligations hereunder terminate; provided, however:

                           (i)  that  the  Holders  will  sell  the  Registrable
Securities  pursuant to such registration  only during a "Permitted  Window" (as
defined below);

                           (ii)  if  the  Company  furnishes  to the  Holders  a
certificate  signed by the President or Chief  Executive  Officer of the Company
stating  that,  in the good  faith  judgment  of the Board of  Directors  of the
Company,  it would be seriously  detrimental to the Company and its shareholders
for sales to be made from such Shelf Registration Statement at such time (or, in
the case a "Notice of Resale" (as defined  below) has been given,  that it would
be seriously  detrimental to the Company and its  shareholders for the Permitted
Window  to  commence  at such  time)  due to (A)  the  existence  of a  material
development or potential  material  development  involving the Company which the
Company would be obligated to disclose in the Prospectus  contained in the Shelf
Registration  Statement,  which disclosure  would, in the good faith judgment of
the  President  or Chief  Executive  Officer  or the Board of  Directors  of the
Company,  be premature or otherwise  inadvisable  at such time or (B) concurrent
public filings with the Commission of other  registration  statements,  then the
Company  will have the right to defer the filing (the  "Deferral  Right") of the
Shelf  Registration  Statement (or the commencement of the Permitted  Window, as
the case may be) for a period of not more  than 60 days  after the date it would
otherwise be required to file the Shelf Registration  Statement pursuant to this
Section  7.2(a) (or after receipt of the Notice of Resale,  as the case may be);
provided,  however,  that the Company will not utilize the  Deferral  Right more
than once in any twelve month period;  and provided further,  however,  that the
Company  may  defer  the  filing of the  Shelf  Registration  Statement  (or the
commencement of the Permitted Window as the case may be) for up to 60 days if so
requested by an underwriter in connection with an  underwritten  offering of the
Company's  securities so long as any selling  shareholders in such  underwritten
offering  are subject to a lock-up  agreement of the same  duration  (other than
with respect to the Company  securities to be sold by such selling  shareholders
in such underwritten offering); and

                           (iii) that the Company will not be required to effect
any such  registration,  qualification or compliance under applicable state blue
sky laws in any  particular  jurisdiction  in which the Company would thereby be
required to qualify to do business or to execute a general consent to service of
process.

                  In the event that the Shelf Registration Statement shall cease
to be effective,  the Company shall promptly prepare and file a new registration
statement covering the Registrable  Securities and shall use its best efforts to
have such registration  statement  declared  effective as soon as possible.  Any
such registration statement shall be considered a "Shelf Registration Statement"
hereunder.

                                       11

<PAGE>

                           (b)  Permitted   Window.For   the  purposes  of  this
Agreement,  a  "Permitted  Window"  with  respect  to a Holder is a period of 30
consecutive  calendar  days  commencing  upon  delivery  to  the  Holder  of the
Company's  written  notification to the Holder in response to a Notice of Resale
that the Prospectus  contained in the Shelf Registration  Statement is available
for resale.  In order to cause a  Permitted  Window to  commence,  a Holder must
first give written  notice to the Company of its present  intention to sell part
or all of the Registrable Securities pursuant to such registration (a "Notice of
Resale").  Upon delivery of such Notice of Resale, the Company will give written
notice  to the  Holders  as soon as  practicable,  but in no event not more than
three  business days after such  delivery,  that (A) the  Permitted  Window will
commence on the date the Company's notice is delivered to the Holder,  (B) it is
necessary for the Company to supplement  the  Prospectus or make an  appropriate
filing under the Exchange Act so as to cause the  Prospectus  to become  current
(unless a certificate of the President or Chief  Executive  Officer is delivered
as provided in 7.2(a)(ii)  above),  or (C) the Company is required under the Act
and the  Rules  and  Regulations  thereunder  to amend  the  Shelf  Registration
Statement in order to cause the  Prospectus to be current  (unless a certificate
of the  President  or Chief  Executive  Officer  is  delivered  as  provided  in
7.2(a)(ii)   above).  If  the  Company  determines  that  a  supplement  to  the
Prospectus,  the filing of a report pursuant to the Exchange Act or an amendment
to the Shelf  Registration  Statement required under the Act, as provided above,
is  necessary,  it will  take such  actions  as soon as  reasonably  practicable
(subject to paragraph (c) below),  and the Company will notify the Holder of the
filing  of  such  supplement,  report  or  amendment,  and,  in the  case  of an
amendment,  the  effectiveness  thereof,  and the  Permitted  Window  will  then
commence.

                           (c) Closing of Permitted  Window.  During a Permitted
Window and in the event (i) of the happening of any event of the kind  described
in Section 7.3(c) hereof or (ii) that, in the judgment of the  President,  Chief
Executive  Officer or the  Company's  Board of  Directors,  it is  advisable  to
suspend use of the Prospectus  for a discrete  period of time due to undisclosed
pending  corporate  developments  or pending  public filings with the Commission
(which need not be described in detail), the Company shall deliver a certificate
in writing to the Holder to the effect of the  foregoing  and,  upon  receipt of
such  certificate,  the Permitted Window shall  terminate.  The Permitted Window
shall resume upon the Holder's  receipt of copies of the supplemented or amended
Prospectus,  or at such time as the Holder is advised in writing by the  Company
that the  Prospectus  may be used,  and at such time as the Holder has  received
copies of any additional or supplemental filings that are incorporated or deemed
incorporated  by  reference  in such  Prospectus  and which are  required  to be
delivered as part of the Prospectus.  In any event,  the Permitted  Window shall
resume  no later  than 45 days  after it has been  terminated  pursuant  to this
Section. If the Company has previously terminated a Permitted Window pursuant to
this  subsection  within 90 days of the date  that it  delivers  another  notice
pursuant this subsection  terminating  another Permitted  Window,  then the time
period  set  forth in the  preceding  sentence  shall be  shortened  so that the
Permitted Window shall resume no later than 10 days after it has been terminated
pursuant to such second notice.

                           (d)  Expenses.  The  registration  fees and  expenses
incurred by the Company in connection with the Shelf Registration  Statement and
actions taken by the Company

                                       12

<PAGE>

in connection with each Permitted  Window shall be borne by the Company.  Holder
shall be responsible for any fees and expenses of its counsel or other advisers.

                  7.3  Obligations of the Company.  Whenever  required to effect
the registration of any Registrable Securities under this Agreement, the Company
shall, as expeditiously as reasonably possible:

                           (a)  Furnish to the Holder such number of copies of a
Prospectus,   including  a  preliminary  Prospectus,   in  conformity  with  the
requirements of the Act, and such other  documents as it may reasonably  request
in order to facilitate the disposition of the Registrable Securities owned by it
that are included in such registration.

                           (b)  Use  all  reasonable  efforts  to  register  and
qualify the securities  covered by such registration  statement under such other
securities  or Blue  Sky  laws of such  jurisdictions  as  shall  be  reasonably
requested  by the Holder,  provided  that the  Company  shall not be required in
connection  therewith or as a condition  thereto to qualify to do business or to
file  a  general   consent  to  service  of  process  in  any  such   states  or
jurisdictions.

                           (c) Notify the Holder  promptly (i) of any request by
the Commission or any other federal or state  governmental  authority during the
period  of  effectiveness   of  a  registration   statement  for  amendments  or
supplements  to  such  registration  statement  or  related  prospectus  or  for
additional  information,  (ii) of the  issuance by the  Commission  or any other
federal  or state  governmental  authority  of any  stop  order  suspending  the
effectiveness  of a registration  statement or the initiation of any proceedings
for that  purpose and (iii) of the  receipt by the  Company of any  notification
with  respect  to  the  suspension  of  the   qualification  or  exemption  from
qualification of any of the Registrable  Securities for sale in any jurisdiction
or the initiation or threatening of any proceeding for such purpose.

                           (d)  Make  every  reasonable  effort  to  obtain  the
withdrawal of any order suspending the  effectiveness of the Shelf  Registration
Statement at the earliest possible time.

                           (e)  If the  registration  involves  an  underwritten
offering,  enter  into an  underwriting  agreement  in  customary  form with the
underwriters containing customary indemnification provisions.

                  7.4 Furnish Information.  It shall be a condition precedent to
the  obligations of the Company to take any action  pursuant to Section 7.2 that
the Holder  shall  furnish to the Company  such  information  regarding  it, the
Registrable  Securities  held by it, and the intended  method of  disposition of
such  securities as shall be required to timely effect the  registration  of its
Registrable Securities.

                  7.5 Indemnification.  In the event any Registrable  Securities
are included in a registration statement under this Agreement:

                           (a) By the Company.  To the extent  permitted by law,
the Company  will  indemnify  and hold  harmless  the Holder,  the  officers and
directors of the Holder and each

                                       13

<PAGE>

person,  if any, who controls the Holder (such persons and entities  referred to
as "Holder  Indemnified  Parties"),  against  any losses,  expenses,  damages or
liabilities  to which they may become subject under the Act, the Exchange Act or
other  federal or state law (a  "Loss"),  insofar as such  Losses (or actions in
respect thereof) arise out of any claim, action or proceeding brought by a third
party arising out of or based upon any of the following statements, omissions or
violations (collectively a "Violation"):

                           (i) any untrue  statement or alleged untrue statement
                  of a material fact contained in a registration statement filed
                  pursuant to this Section 7;

                           (ii) the  omission or alleged  omission to state in a
                  registration  statement  filed  pursuant  to this  Section 7 a
                  material fact required to be stated  therein,  or necessary to
                  make the statements therein not misleading; or

                           (iii)  any  violation  or  alleged  violation  by the
                  Company of the Act,  the  Exchange  Act,  any federal or state
                  securities law or any rule or regulation promulgated under the
                  Act, the Exchange Act or any federal or state  securities law,
                  in each case in connection  with the offering  covered by such
                  registration statement;

and the Company will  reimburse each Holder  Indemnified  Party for any legal or
other  expenses  reasonably  incurred by them, as incurred,  in connection  with
investigating  or defending  any such  Violation;  provided,  however,  that the
indemnity agreement contained in this subsection shall not apply to amounts paid
in  settlement  of any such Loss,  if such  settlement  is effected  without the
consent of the Company, nor shall the Company be liable in any such case for any
such Loss to the extent that it arises out of or is based upon a Violation which
occurs in reliance upon and in  conformity  with written  information  furnished
expressly for use in connection with such  registration  statement by the Holder
Indemnified Party; and provided further, that the Company will not be liable for
the  reasonable  legal fees and  expenses of more than one counsel to the Holder
Indemnified Parties.

                           (b) By the Holder.  To the extent  permitted  by law,
each Holder will indemnify and hold harmless the Company, each of its directors,
each of its  officers  who have  signed  the  registration  statement,  and each
person,  if any, who  controls  the Company  within the meaning of the Act (such
persons and entities referred to as "Company  Indemnified  Parties") against any
Losses to which such Company  Indemnified  Parties may become  subject under the
Act, the Exchange Act or other federal or state law,  insofar as such Losses (or
actions in respect  thereto)  arise out of or are based upon any  Violation,  in
each case to the extent (and only to the extent) that such  Violation  occurs in
reliance upon and in conformity with written information furnished by the Holder
expressly for use in connection with such registration statement; and the Holder
will reimburse any legal or other expenses  reasonably  incurred by such Company
Indemnified  Parties in  connection  with  investigating  or defending  any such
Violation;  provided,  however,  that the indemnity  agreement contained in this
subsection  shall not apply to amounts

                                       14

<PAGE>

paid in settlement of any such Loss if such  settlement is effected  without the
consent of the Holder; provided further, that the Holder shall not be liable for
the  reasonable  legal fees and expenses of more than one counsel to the Company
Indemnified  Parties;  and provided  further,  that the total amounts payable in
indemnity by the Holder under this  subsection in respect of any Violation shall
not exceed the net proceeds  received by the Holder in the  registered  offering
out of which such Violation arises.

                           (c) Notice.  Promptly after receipt by an indemnified
party under this Section of notice of the commencement of any action  (including
any  governmental   action),  such  indemnified  party  will,  if  a  claim  for
indemnification  in respect thereof is to be made against any indemnifying party
under this Section,  deliver to the  indemnifying  party a written notice of the
commencement of such an action and the  indemnifying  party shall have the right
to participate in, and, to the extent the indemnifying party so desires, jointly
with any other  indemnifying  party  similarly  noticed,  to assume the  defense
thereof  with  counsel  selected  by  the  indemnifying   party  and  reasonably
acceptable  to a majority  in  interest of the  indemnified  parties;  provided,
however,  that an  indemnified  party  shall  have the right to  retain  its own
counsel,  with the reasonable  fees and expenses to be paid by the  indemnifying
party,  if the  indemnified  party has been  advised in writing by counsel  that
representation  of  such  indemnified  party  by  the  counsel  retained  by the
indemnifying  party would be  inappropriate  due to actual conflict of interests
between such indemnified  party and any other party  represented by such counsel
in such  proceeding.  The failure to deliver written notice to the  indemnifying
party  within a  reasonable  time of the  commencement  of any such action shall
relieve such indemnifying party of liability to the indemnified party under this
Section to the extent such delay  caused  actual  prejudice  to the  indemnified
party, but the omission so to deliver written notice to the  indemnifying  party
will not relieve it of any liability that it may have to any  indemnified  party
otherwise than under this Section.

                           (d)  Contribution.  In order to provide  for just and
equitable  contribution  to joint  liability  under the Act in any case in which
either (i) a Holder Indemnified Party makes a claim for indemnification pursuant
to  this  Section  but it is  judicially  determined  (by the  entry  of a final
judgment or decree by a court of competent  jurisdiction  and the  expiration of
time  to  appeal  or  the  denial  of  the  last  right  of  appeal)  that  such
indemnification  may not be enforced in such case  notwithstanding the fact that
this Section  provides for  indemnification  in such case, or (ii)  contribution
under the Act may be  required  on the part of the Holder  Indemnified  Party in
circumstances for which indemnification is provided under this Section then, and
in  each  such  case,  the  Company  and the  Holder  Indemnified  Parties  will
contribute  to  the  aggregate  Losses  to  which  they  may be  subject  (after
contribution from others) in proportion to their relative fault as determined by
a court of competent jurisdiction; provided however, that in no event, except in
instances of fraud by the Holder in which there is no limitation,  (i) shall the
Holder be  responsible  for more than the portion  represented by the percentage
that the public offering price of its Registrable Securities offered by and sold
under the  registration  statement  bears to the  public  offering  price of all
securities offered by and sold under such registration  statement and (ii) shall
the Holder be required to contribute any amount in excess of the public offering
price of all such Registrable Securities offered and sold by the Holder pursuant
to such registration statement;  and in any event, no person or entity guilty of
fraudulent

                                       15

<PAGE>

misrepresentation  (within  the  meaning  of  Section  11(f) of the Act) will be
entitled  to  contribution  from any person or entity who was not guilty of such
fraudulent misrepresentation.

                           (e)  Defect  Eliminated  in  Final  Prospectus.   The
foregoing indemnity  agreements of the Company and the Holder are subject to the
condition  that,  insofar as they relate to any Violation  made in a preliminary
prospectus but eliminated or remedied in the amended prospectus on file with the
Commission at the time the registration  statement in question becomes effective
or in the amended  prospectus filed with the Commission  pursuant to Rule 424(b)
of the Commission (the "Final Prospectus"),  such indemnity agreements shall not
inure  to the  benefit  of any  person  if a copy of the  Final  Prospectus  was
furnished in a timely manner to the  indemnified  party and was not furnished to
the person  asserting  the loss,  liability,  claim or damage at or prior to the
time such action is required by the Act.

                           (f) Survival.  The obligations of the Company and the
Holder  under this  Section  shall  survive the  completion  of any  offering of
Registrable Securities in a registration statement, and otherwise.

                  7.6 Rule 144  Reporting.  With a view to making  available the
benefits of certain rules and  regulations  of the  Commission  which may at any
time  permit  the  sale of the  Registrable  Securities  to the  public  without
registration,  for so long as the Holder owns any  Registrable  Securities,  the
Company agrees to:

                           (a)   Make   and  keep   adequate,   current   public
information  available,  as those terms are  understood  and defined in Rule 144
under the Act, at all times;

                           (b) File with the  Commission  in a timely manner all
reports and other documents required of the Company under the Exchange Act; and

                           (c)  So  long  as the  Holder  owns  any  Registrable
Securities,  to furnish to the Holder forthwith upon request a written statement
by the Company as to its compliance with the reporting requirements of said Rule
144, a copy of the most recent  annual or quarterly  report of the Company,  and
such other  reports and  documents  of the Company as the Holder may  reasonably
request in availing itself of any rule or regulation of the Commission  allowing
a Holder to sell any such securities without registration.

                  7.7  Termination of Cellegy's  Obligations.  The Company shall
have no obligation to register, or maintain, a registration  statement governing
Registrable  Securities,  (i) if all Registrable Securities have been registered
and sold pursuant to registrations effected pursuant to this Agreement,  or (ii)
with  respect  to any  particular  Holder,  at  such  time  as  all  Registrable
Securities  held by such  Holder may be sold  without  any  volume  restrictions
within a three month  period  under Rule 144, as it may be amended  from time to
time,  including but not limited to  amendments  that reduce that period of time
that securities must be held before such securities may be sold pursuant to such
rule.

                  7.8  Piggyback  Registrations.  (a) The Company  shall use its
best efforts to notify all Holders of Registrable Securities in writing at least
twenty  (20) days before  filing any

                                       16

<PAGE>

registration  statement  under the Act for purposes of effecting an underwritten
public  offering  by  the  Company  of  securities  of  the  Company  (excluding
registration  statements  relating to any  employee  benefit plan or a corporate
merger,   acquisition  or   reorganization,   or  any  Form  S-3  similar  shelf
registration  statements  relating  to the  non-underwritten  offer  and sale of
securities  for the account of persons or entities  other than the  Company) and
will  afford  each such Holder an  opportunity  to include in such  registration
statement  all or any  part  of the  Registrable  Securities  then  held by such
Holder.  Each Holder desiring to include in any such registration  statement all
or any part of the Registrable  Securities held by such Holder shall, within ten
(10) days after  receipt of the  above-described  notice  from the  Company,  so
notify the Company in writing,  and in such notice  shall  inform the Company of
the  number of  Registrable  Securities  such  Holder  wishes to include in such
registration  statement.  If  a  Holder  decides  not  to  include  all  of  its
Registrable  Securities in any such registration statement filed by the Company,
such  Holder  shall  nevertheless  continue  to have the  right to  include  any
Registrable Securities in any subsequent  registration statement or registration
statements  as may be filed by the  Company  with  respect to  offerings  of its
securities,  all upon the terms and  conditions  set forth herein.  The Holders'
rights to include any Registrable  Securities in any offering under this Section
are subject in all events to the ability of the  managing  underwriter  for such
offering to exclude some or all of the  Registrable  Securities  requested to be
registered  on the basis of a good faith  determination  that  inclusion of such
securities  might  adversely  affect the success of the  offering  or  otherwise
adversely  affect the Company.  Any such  exclusion  shall be pro rata among all
Holders who have requested to sell Registrable Securities in such registration.

                           (b) Underwriting.  If a registration  statement under
which the  Company  gives  notice  under  this  Section  is for an  underwritten
offering,   then  the  Company  shall  so  advise  the  Holders  of  Registrable
Securities. In such event, the right of any such Holder's Registrable Securities
to be included in a  registration  pursuant to this Section shall be conditioned
upon such Holder's  participation in such underwriting and the inclusion of such
Holder's  Registrable  Securities  in the  underwriting  to the extent  provided
herein. All Holders proposing to distribute their Registrable Securities through
such underwriting  shall enter into an underwriting  agreement in customary form
with the managing underwriter or underwriters selected for such underwriting and
shall  furnish  such  information  and  documents as the Company or the managing
underwriter or underwriters may reasonably  request.  Notwithstanding  any other
provision of this Agreement,  if the managing  underwriter  determine(s) in good
faith that marketing  factors require a limitation of the number of shares to be
underwritten,   then  the  managing   underwriter(s)  may  exclude   Registrable
Securities  from the  registration  and the  underwriting,  pro rata  among  all
Holders who have requested to sell Registrable  Securities in such registration.
If any Holder disapproves of the terms of any such underwriting, such Holder may
elect  to  withdraw   therefrom  by  written  notice  to  the  Company  and  the
underwriter,  delivered at least ten (10)  business  days prior to the effective
date of the  registration  statement.  Any  Registrable  Securities  excluded or
withdrawn  from such  underwriting  shall be  excluded  and  withdrawn  from the
registration.

                           (c) Expenses.  The Holders shall be  responsible  for
their  pro  rata  share of  registration  fees and  underwriters'  and  brokers'
discounts and  commissions  relating to any Registrable  Securities  included in
such  registration.  Other  registration  expenses (such as legal

                                       17

<PAGE>

and  accounting  fees of  counsel  to the  Company,  printing  fees,  road  show
expenses, and the like) shall be shall be borne by the Company.

                           (d) Number of Piggyback Registrations.  The piggyback
registration rights granted to the Holders under this Section shall apply to the
first three registrations filed by the Company after the Closing.

         8.       ASSIGNMENT.  Notwithstanding  anything herein to the contrary,
the  registration  rights of the Holder  under  Section 7 hereof may be assigned
only to a party  who  acquires  from the  Holder  at  least  100,000  shares  of
Registrable  Securities (as such number may be adjusted to reflect subdivisions,
combinations and stock dividends of the Company's Common Stock),  (such party is
referred  to as a  "Assignee");  provided,  however,  that (w) no  party  may be
assigned any of the foregoing  rights until the Company is given written  notice
by the  assigning  party at the  time of such  assignment  stating  the name and
address of the  Assignee and  identifying  the  securities  of the Company as to
which the rights in  question  are being  assigned;  (x) that any such  Assignee
shall receive such assigned  rights  subject to all the terms and  conditions of
this  Agreement;  and (y) no such  assignment or assignments  shall increase the
obligations of the Company hereunder.

         9.       MISCELLANEOUS.

                  9.1 Survival of Warranties.  The  representations,  warranties
and covenants of the Company and the Investors  contained in or made pursuant to
this  Agreement  shall survive the execution and delivery of this  Agreement and
the Closing and shall in no way be affected by any  investigation of the subject
matter  thereof  made by or on behalf of the  Investors,  their  counsel  or the
Company, as the case may be.

                  9.2 Successors  and Assigns.  The terms and conditions of this
Agreement  shall  inure to the  benefit  of and be binding  upon the  respective
successors and assigns of the parties.

                  9.3 Governing  Law;  Consent to  Jurisdiction.  This Agreement
shall be  governed  by and  construed  under the  internal  laws of the State of
California as applied to agreements among California  residents entered into and
to be performed entirely within  California,  without reference to principles of
conflict of laws or choice of laws.

                  9.4  Counterparts.  This  Agreement  may be executed in two or
more counterparts,  each of which shall be deemed an original,  but all of which
together shall constitute one and the same instrument.

                  9.5 Headings. The headings and captions used in this Agreement
are used for  convenience  only and are not to be  considered  in  construing or
interpreting  this  Agreement.  All  references  in this  Agreement to sections,
paragraphs,  exhibits and schedules shall, unless otherwise  provided,  refer to
sections and paragraphs hereof and exhibits and schedules  attached hereto,  all
of which exhibits and schedules are incorporated herein by this reference.

                                       18

<PAGE>

                  9.6 Notices. Unless otherwise provided, any notice required or
permitted  under this  Agreement  shall be given in writing  and shall be deemed
effectively  given  upon  personal  delivery  to the  party to be  notified,  by
telecopier or upon deposit with the United States Post Office,  by registered or
certified mail, postage prepaid and addressed to the party to be notified in the
case of the Company,  at 349 Oyster Point  Boulevard,  South San  Francisco,  CA
94080, attention:  President, with a copy to C. Kevin Kelso, Fenwick & West LLP,
Two Palo Alto Square,  Palo Alto,  California 94306, or in the case of Investor,
at the  record  address  for such  Investor  as  reflected  on the  books of the
Company,  with a copy to  Peter  Ingerman,  Esq.,  Chadbourne  & Parke  LLP,  30
Rockefeller  Plaza,  New York,  New York 10112,  or at such other address as any
party may designate by giving ten (10) days advance  written notice to the other
party. Notices shall be deemed delivered upon delivery if personally  delivered,
one  business day after  transmission  with  confirmation  of receipt if sent by
telecopier, or three days after deposit in the mails if mailed.

                  9.7 No Finder's Fees. Each party represents that it neither is
nor  will be  obligated  for any  finder's  or  broker's  fee or  commission  in
connection with this transaction.  Each Investor agrees to indemnify and to hold
harmless the Company from any liability for any  commission or  compensation  in
the nature of a finder's or broker's fee (and any asserted  liability) for which
the Investor or any of its officers, partners,  employees, or representatives is
responsible.  The Company agrees to indemnify and to hold harmless each Investor
from any  liability  for any  commission  or  compensation  in the  nature  of a
finder's or broker's fee (and any asserted  liability)  for which the Company or
any of its officers, employees or representatives is responsible.

                  9.8 Costs, Expenses. Each party's costs in connection with the
preparation,  execution  delivery and  performance of this Agreement  (including
without limitation legal fees) shall be borne by that party.

                  9.9 Amendments and Waivers.  Any term of this Agreement may be
amended and the  observance of any term of this  Agreement may be waived (either
generally   or  in  a   particular   instance   and  either   retroactively   or
prospectively),  only with the  written  consent of the  Company  and  Investors
holding a  majority  of the  Purchased  Shares  purchased  hereunder;  provided,
however,  that no amendment or waiver of the Company's obligations under Section
7 of this Agreement shall be binding upon any holder of Purchased  Shares unless
that holder has consented in writing to such amendment or waiver. Subject to the
limitations  set  forth in the  preceding  sentence,  any  amendment  or  waiver
effected in  accordance  with this Section  shall be binding upon each holder of
any  Purchased  Shares at the time  outstanding  (even if such Investor or other
holder  did not vote  with  respect  to, or voted  against,  such  amendment  or
waiver),  each future holder of such securities,  and the Company. The Investors
acknowledge  that by virtue of this  provision,  holders  of a  majority  of the
Purchase  Shares may bind other  holders to amendment or waivers that such other
holders may have voted to oppose.

                  9.10 Severability. If one or more provisions of this Agreement
are held to be invalid,  illegal or  unenforceable  under  applicable  law, such
provision(s)  shall be  excluded  from

                                       19

<PAGE>

this Agreement and the balance of the Agreement  shall be interpreted as if such
provision(s)  were so excluded and shall be enforceable  in accordance  with its
terms.

                  9.11  Entire  Agreement.  This  Agreement,  together  with any
exhibits or schedules hereto, constitutes the entire agreement and understanding
of the parties with respect to the subject  matter hereof and supersedes any and
all prior negotiations,  correspondence,  agreements,  understandings  duties or
obligations between the parties with respect to the subject matter hereof.

                  9.12  Further  Assurances.  From  and  after  the date of this
Agreement,  upon the request of an Investor or the Company,  the Company and the
Investors  shall  execute  and  deliver  such  instruments,  documents  or other
writings as may be  reasonably  necessary  or desirable to confirm and carry out
and to effectuate fully the intent and purposes of this Agreement.



[Remainder of this page intentionally left blank]

                                       20

<PAGE>

         COUNTERPART SIGNATURE PAGE

         COMMON STOCK PURCHASE AGREEMENT


         IN WITNESS WHEREOF,  the parties hereto have executed this Common Stock
Purchase Agreement as of the date first above written.

THE COMPANY:                            INVESTOR:

Cellegy Pharmaceuticals, Inc.,          FOUR PARTNERS
  a California corporation



By: /s/ K. Michael Forrest              By: /s/ Thomas J. Tisch
    ------------------------------          -------------------------------

Title: President & CEO                  Title: Trustee
       ---------------------------             ----------------------------

                                       20

<PAGE>

         COUNTERPART SIGNATURE PAGE

         COMMON STOCK PURCHASE AGREEMENT


         IN WITNESS WHEREOF,  the parties hereto have executed this Common Stock
Purchase Agreement as of the date first above written.

THE COMPANY:                            INVESTOR:

Cellegy Pharmaceuticals, Inc.,          Bay Resource Partners, L.P.
  a California corporation



By: /s/ K. Michael Forrest                  By: /s/ Steven E. Levy
    ------------------------------          -------------------------------
        K. Michael Forrest                          Steven E. Levy

Title: President & CEO                 Title: Vice President
       ---------------------------            GMT Capital Corp.
                                              -----------------------------

                                       21

<PAGE>

         COUNTERPART SIGNATURE PAGE

         COMMON STOCK PURCHASE AGREEMENT


         IN WITNESS WHEREOF,  the parties hereto have executed this Common Stock
Purchase Agreement as of the date first above written.

THE COMPANY:                            INVESTOR:

Cellegy Pharmaceuticals, Inc.,          Bay Resource Partners Offshore, Ltd.
  a California corporation



By: /s/ K. Michael Forrest                  By: /s/ Steven E. Levy
    ------------------------------          -------------------------------
        K. Michael Forrest                          Steven E. Levy

Title: President & CEO                 Title: Vice President
       ---------------------------            GMT Capital Corp.
                                              -----------------------------

                                       21

<PAGE>

         COUNTERPART SIGNATURE PAGE

         COMMON STOCK PURCHASE AGREEMENT


         IN WITNESS WHEREOF,  the parties hereto have executed this Common Stock
Purchase Agreement as of the date first above written.

THE COMPANY:                            INVESTOR:

Cellegy Pharmaceuticals, Inc.,          Janus Global Life Sciences Fund
  a California corporation



By: /s/ K. Michael Forrest              By: /s/ Deborah Bielicke Eades
    ------------------------------          -------------------------------
        K. Michael Forrest                      Deborah Bielicke Eades

Title: President & CEO                 Title: Assistant Vice President
       ---------------------------            -----------------------------

                                       20

<PAGE>

         COUNTERPART SIGNATURE PAGE

         COMMON STOCK PURCHASE AGREEMENT


         IN WITNESS WHEREOF,  the parties hereto have executed this Common Stock
Purchase Agreement as of the date first above written.

THE COMPANY:                            INVESTOR:

Cellegy Pharmaceuticals, Inc.,          K. Michael Forrest & Nhu
  a California corporation              Forrest, Jyten



By: /s/ K. Michael Forrest                  By: /s/ K. Michael Forrest
    ------------------------------          -------------------------------
        K. Michael Forrest                          K. Michael Forrest


Title: President & CEO                 Title:
       ---------------------------            -----------------------------

                                       21

<PAGE>

                              SCHEDULE OF INVESTORS

<TABLE>
         The  price per share of common  stock  paid by all  Investors  shall be
$6.25 per share.

<CAPTION>

Name                               Address                                                      Number
- ----                               -------                                                      ------
                                                                                                of Shares
                                                                                                ---------

<S>                                <C>                                                          <C>
Four Partners                      Tisch Financial Management                                   720,000
                                   Attention:  Barry Bloom
                                   655 Madison Avenue, 8th Floor
                                   New York, NY  10021

Bay Resource Partners, L.P.        GMT Capital Corp.                                            40,000
                                   Attention:  Greg Deese
                                   2100 River Edge Parkway, Suite 840
                                   Atlanta, GA  30328

Bay Resource Partners Offshore     GMT Capital Corp.                                            56,000
Ltd.                               Attention:  Greg Deese
                                   2100 River Edge Parkway, Suite 840
                                   Atlanta, GA  30328

Janus Global Life                  Chase Manhattan Bank, NA                                     720,000
Sciences Fund                      Attention:  Matt Rollo
                                   In Account of State Street Bank & Trust Co.
                                   4 New York Plaza, Ground Floor, Receive Window
                                   New York, NY 10004

K. Michael Forrest & Nhu           c/o Cellegy Pharmaceuticals, Inc.                            25,000
Forrest, JY TEN                    Attention:  K. Michael Forrest
                                   349 Oyster Point Blvd., Suite 200
                                   South San Francisco, CA  94080

TOTAL                                                                                           1,561,000
- -----

</TABLE>




                                                                     EXHIBIT 4.2

THE SECURITIES  REPRESENTED BY THIS WARRANT CERTIFICATE HAVE NOT BEEN REGISTERED
UNDER THE  SECURITIES ACT OF 1933 (THE "ACT") OR ANY STATE  SECURITIES  LAWS AND
MAY NOT BE SOLD, EXCHANGED,  PLEDGED,  HYPOTHECATED OR TRANSFERRED IN ANY MANNER
(A "TRANSFER") EXCEPT IN COMPLIANCE WITH THE TERMS OF THIS WARRANT,  THE ACT AND
ANY  APPLICABLE  STATE  SECURITIES  LAWS OR THE  COMPANY  RECEIVES AN OPINION OF
COUNSEL FOR THE HOLDER OF THESE SECURITIES SATISFACTORY TO THE COMPANY,  STATING
THAT SUCH  TRANSFER  IS EXEMPT FROM THE  REGISTRATION  AND  PROSPECTUS  DELIVERY
REQUIREMENTS OF THE ACT AND COMPLIES WITH APPLICABLE STATE SECURITIES LAWS.




                                                     Warrant Certificate No. 409


                               WARRANT TO PURCHASE
                             SHARES OF COMMON STOCK
                          CELLEGY PHARMACEUTICALS, INC.

THIS  WARRANT (the  "Warrant")  is dated as of January 18, 1999 and is issued by
Cellegy  Pharmaceuticals,  Inc., a California  corporation (the  "Company"),  to
Michael P.  Crowley  ("Warrantholder"),  in the amount of up to 2,000  Warrants,
subject to other  conditions of this warrant and the consulting  agreement dated
January 16, 1999.

         Section 1.  Definitions

                  1.1 Definitions.  For purposes of this Warrant,  the following
terms shall have the following meanings.

                  "Act" shall mean the Securities Act of 1933, as amended.

                  "Common Stock" means the Company's Common Stock, no par value.

                  "Exercise Price" has the meaning given to that term in Section
2.2.

                  "Merger or Sale" shall have the meaning  given to that term in
Section 7.3.

                  "Shares"  shall  mean the  shares of Common  Stock that can be
acquired upon exercise of the Warrant.

                  "Termination Date" shall mean the date on which the Warrant is
no longer  exercisable,  which  date  shall be no later  than one year after the
completion of the  consulting  agreement  (July 2, 2000) between the Company and
Dr. Crowley.

<PAGE>

                  "Transfer  Agent"  shall  mean  the  Company's  registrar  and
transfer agent, if any, for the Warrant.

                  "Warrant" shall mean this Warrant to purchase shares of Common
Stock.  The term "Warrant" shall include any Warrant  evidenced by a certificate
or  certificates  issued  upon  division,  exchange,  substitution  or  transfer
pursuant to the terms of this Warrant.


         Section 2.  Issuance of Warrant; Form of Warrant.

                  2.1 Issuance. In consideration of the Warrantholder's services
on  behalf  of the  Company,  the  Company  hereby  issues  the  Warrant  to the
Warrantholder   to  purchase   2,000  shares  of  Common  Stock.

                  2.2  Exercise  Price and  Exercise  Conditions.  The price per
share at which 2,000 shares shall be  purchasable  upon  exercise of the Warrant
(the  "Exercise  Price")  is  $4.6875  per  share.

                  2.3  Registration.  The Warrant shall be numbered and shall be
registered on the books of the Company.

                  2.4 Transfer.  The Warrant may not be  transferred,  except to
members of the Warrantholder's immediate family or trusts for the benefit of the
Warrantholder or one or more members of the Warrantholder's immediate family. To
the extent that the Warrant is  transferable,  the Warrant shall be transferable
only on the books of the Company  maintained at its  principal  office in Foster
City,  California (or wherever its principal  office may then be located) or, if
the Company has a Transfer  Agent,  then at the offices of the  Transfer  Agent,
upon  delivery  thereof  duly  endorsed  by the  Warrantholder  or by  its  duly
authorized  attorney  or  representative,  accompanied  by  proper  evidence  of
succession,  assignment  or  authority  to transfer.  Upon any  registration  of
transfer,  the  Company  shall  execute  and deliver a new Warrant to the person
entitled thereto.

                  2.5 Certificates. The Warrant may be divided or combined, upon
request to the Company by the Warrantholder,  into a certificate or certificates
representing the right to purchase the same aggregate  number of Shares.  Unless
the context  indicates  otherwise,  the term  "Warrantholder"  shall include any
transferee or transferees of the Warrant.

                  2.6 Signatures. The number of Shares issuable upon exercise of
the Warrant is subject to adjustment upon the occurrence of certain events,  all
as hereinafter provided.  The Warrant shall be executed on behalf of the Company
by its  President or by a Vice  President and attested to by its Secretary or an
Assistant Secretary. A Warrant bearing the signature of an individual who was at
any  time  the  proper   officer  of  the  Company   shall  bind  the   Company,
notwithstanding that such individual shall have ceased to hold such office prior
to the  delivery of such Warrant or did not hold such office on the date of this
Warrant.


                                      -2-
<PAGE>

                  2.7 Legends on Certificate.  Each certificate representing the
Warrant,  and for Shares  initially  issued upon exercise of the Warrant,  shall
bear the following  legends,  unless,  at the time of exercise,  such Shares are
subject to a currently effective Registration Statement under the Act:

                           (a)  THE  SECURITIES   REPRESENTED  BY  THIS  WARRANT
CERTIFICATE  HAVE NOT BEEN  REGISTERED  UNDER  THE  SECURITIES  ACT OF 1933 (THE
"ACT") OR ANY STATE  SECURITIES  LAWS AND MAY NOT BE SOLD,  EXCHANGED,  PLEDGED,
HYPOTHECATED  OR TRANSFERRED  IN ANY MANNER (A "TRANSFER")  EXCEPT IN COMPLIANCE
WITH THE TERMS OF THIS WARRANT, THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS
OR THE COMPANY RECEIVES AN OPINION OF COUNSEL FOR THE HOLDER OF THESE SECURITIES
SATISFACTORY  TO THE  COMPANY,  STATING  THAT SUCH  TRANSFER  IS EXEMPT FROM THE
REGISTRATION AND PROSPECTUS  DELIVERY  REQUIREMENTS OF THE ACT AND COMPLIES WITH
APPLICABLE STATE SECURITIES LAWS.

                           (b)  Any  legend   required   by   applicable   state
securities laws.

                  Any certificate issued at any time in exchange or substitution
for any certificate  bearing such legends (except a new certificate  issued upon
completion of a public distribution  pursuant to a registration  statement under
the Act of the securities represented thereby) shall also bear the above legends
unless,  in the opinion of the Company's  counsel,  the  securities  represented
thereby need no longer be subject to such restrictions.

                  2.8 Exchange of Warrant  Certificate.  Any Warrant certificate
may  be  exchanged  for  another  certificate  or  certificates   entitling  the
Warrantholder  to purchase a like aggregate  number of Shares as the certificate
or certificates  surrendered then entitled such  Warrantholder to purchase.  Any
Warrantholder desiring to exchange a Warrant certificate shall make such request
in writing  delivered to the Company,  and shall surrender,  properly  endorsed,
with  signatures   guaranteed  if  required  by  the  Company,  the  certificate
evidencing the Warrant to be so exchanged.  Thereupon, the Company shall execute
and  deliver to the person  entitled  thereto a new  Warrant  certificate  as so
requested.

         Section 3. Term of Warrant; Exercise of Warrant.

                  3.1  Term.   Subject  to  the  terms  of  this  Warrant,   the
Warrantholder  shall have the right,  at any time after the date of this Warrant
and ending at 5:00 p.m.,  California  Time, on the Termination  Date to purchase
from the  Company  up to the number of fully  paid and  nonassessable  Shares to
which the Warrantholder may at the time be entitled to purchase pursuant to this
Warrant,  upon  surrender  to the  Company,  at  its  principal  office,  of the
certificate  evidencing the Warrant to be exercised,  together with the purchase
form, duly filled in and signed,  with signatures  guaranteed if required by the
Company or its Transfer  Agent,  and upon payment to the Company of the Exercise
Price  for the  number  of  Shares  in  respect  of which  the  Warrant  is then
exercised,  but in no event  for less  than 100  Shares  (unless  fewer  than an
aggregate  of  100  Shares  are  then  purchasable  pursuant  to  the  Warrant).
Notwithstanding the foregoing, the Company shall not be obligated to deliver any
Shares pursuant to the exercise of the Warrant,  and



                                      -3-
<PAGE>

the  Warrantholder  shall not have the right to exercise the Warrant,  if in the
Company's  opinion the delivery of Shares upon exercise of the Warrant would not
comply  with any  applicable  federal  or state  securities  laws;  and  without
limiting  the  foregoing,  the Warrant may not be  exercised  by, or  securities
issued  to,  any  Warrantholder  in any state in which  such  exercise  would be
unlawful.

                  3.2  Payment  of  Exercise  Price.  Payment  of the  aggregate
Exercise Price shall be made in cash or by check, or any combination thereof.

                  3.3  Issuance  of  Certificate.  Upon  such  surrender  of the
Warrant and payment of such Exercise Price, the Company shall issue and cause to
be delivered to the Warrantholder and in the Warrantholder's name, a certificate
or certificates  for the number of full Shares so purchased upon the exercise of
the  Warrant,  together  with  cash,  as  provided  herein,  in  respect  of any
fractional  Share otherwise  issuable upon such surrender.  Such  certificate or
certificates shall be deemed to have been issued and any person so designated to
be named  therein  shall be  deemed  to have  become a holder  of record of such
securities  as of the  date of  surrender  of the  Warrant  and  payment  of the
Exercise   Price,  as  aforesaid,   notwithstanding   that  the  certificate  or
certificates   representing   such  securities  shall  not  actually  have  been
delivered.   The  Warrant  shall  be   exercisable,   at  the  election  of  the
Warrantholder,  either in full or from  time to time in part  and,  in the event
that a certificate  evidencing  the Warrant is exercised in respect of less than
all of the Shares specified therein at any time prior to the Termination Date, a
new certificate  evidencing the remaining  portion of the Warrant will be issued
by the Company.

         Section 4. Payment of Taxes.

         The Company will pay all documentary stamp taxes, if any,  attributable
to the initial issuance of the Warrant or the securities  comprising the Shares;
provided, however, the Company shall not be required to pay any tax which may be
payable in respect of any transfer of the Warrant or the  securities  comprising
the Shares.

         Section 5. Mutilated or Missing Warrants.

         In case the certificate or certificates evidencing the Warrant shall be
mutilated,  lost, stolen or destroyed,  the Company shall, at the request of the
Warrantholder,  issue and  deliver in  exchange  and  substitution  for and upon
cancellation  of the mutilated  certificate or  certificates,  or in lieu of and
substitution for the certificate or certificates  lost,  stolen or destroyed,  a
new  Warrant  certificate  or  certificates  of like tenor and  representing  an
equivalent right or interest,  but only upon receipt of evidence satisfactory to
the Company of such loss,  theft or  destruction  of such  Warrant and a bond of
indemnity,  if  requested,   also  satisfactory  in  form  and  amount,  at  the
applicant's cost.  Applicants for such substitute Warrant certificate shall also
comply  with such other  reasonable  regulations  and pay such other  reasonable
charges as the Company may prescribe.

                                      -4-
<PAGE>

         Section 6. Reservation of Shares.

         There  has been  reserved,  and the  Company  shall at all  times  keep
reserved so long as the Warrant remains  outstanding,  out of its authorized and
unissued Common Stock, such number of shares of Common Stock as shall be subject
to purchase under the Warrant.

         Section 7. Adjustment of Number of Shares.

         The number and kind of securities  purchasable upon the exercise of the
Warrant and the Exercise Price shall be subject to adjustment  from time to time
upon the happening of certain events, as follows:

                  7.1  Adjustments.  The number of Shares  purchasable  upon the
exercise of the Warrant shall be subject to adjustment as follows:

                           (a)  Stock  Splits;  Stock  Dividends.  In  case  the
Company shall (i) pay a dividend in Common Stock, (ii) subdivide its outstanding
Common Stock,  (iii) combine its outstanding  Common Stock into a smaller number
of shares of Common Stock,  including without  limitation any combination of its
outstanding  Common Stock that may occur after October 1, 1997, or (iv) issue by
reclassification  of its Common Stock other securities of the Company,  then the
number of Shares  purchasable  upon  exercise of the Warrant  immediately  prior
thereto shall be adjusted so that the Warrantholder shall be entitled to receive
upon  exercise of the Warrant the kind and number of Shares or other  securities
of the Company  which it would have owned or would have been entitled to receive
immediately  after the happening of any of the events  described  above, had the
Warrant been exercised  immediately  prior to the happening of such event or any
record  date  with  respect  thereto.  Any  adjustment  made  pursuant  to  this
subsection shall become effective  immediately  after the effective date of such
event, retroactive to the record date, if any, for such event.

                           (b) De Minimis  Changes.  No adjustment in the number
of Shares  purchasable  pursuant  to the Warrant  shall be required  unless such
adjustment  would require an increase or decrease of at least one percent in the
number of Shares then purchasable upon the exercise of all Commitment  Warrants;
provided,  however,  that any adjustments which by reason of this subsection are
not  required  to be made  immediately  shall be carried  forward and taken into
account in any subsequent adjustment.

                           (c)  Corresponding   Adjustment  of  Exercise  Price.
Whenever  the number of Shares  purchasable  upon the exercise of the Warrant is
adjusted,  as herein  provided,  the Exercise Price payable upon exercise of the
Warrant shall be adjusted by multiplying such Exercise Price  immediately  prior
to such adjustment by a fraction,  the numerator of which shall be the number of
Shares  purchasable upon the exercise of the Warrant  immediately  prior to such
adjustment,  and the  denominator  of which  shall be the  number  of  Shares so
purchasable immediately thereafter.

                           (d)  Notice of  Adjustment.  Whenever  the  number of
Shares  purchasable  upon the  exercise  of the  Warrant is  adjusted  as herein
provided,  the Company  shall

                                      -5-
<PAGE>

cause to be mailed to the  Warrantholder  within a  reasonable  time  thereafter
notice of such adjustment  setting forth the number of Shares  purchasable  upon
the  exercise of the Warrant  after such  adjustment,  a brief  statement of the
facts requiring such adjustment and the computation by which such adjustment was
made.

                  7.2  No  Adjustment  for  Dividends.  Except  as  provided  in
subsection  7.1(a),  no adjustment in respect of any dividends or  distributions
out of  earnings  shall  be made  during  the  term of the  Warrant  or upon the
exercise of the Warrant.

                  7.3  Preservation  of Purchase  Rights upon  Reclassification,
Consolidation, etc.

                           (a) Subject to paragraph (b) of this Section, in case
of any  consolidation  of the Company with or merger of the Company into another
corporation where the Company will not be the surviving corporation,  or in case
of any sale or conveyance  to another  corporation  of the  property,  assets or
business of the Company as an entirety or substantially as an entirety (any such
event  referred  to as a "Merger or Sale"),  the  Company or such  successor  or
purchasing  corporation,  as the case may be, shall agree that the Warrantholder
shall have the right  thereafter  upon payment of the  Exercise  Price in effect
immediately prior to such action to purchase,  upon exercise of the Warrant, the
kind and amount of shares and other  securities and property which it would have
owned or have been  entitled to receive  after the  happening  of such Merger or
Sale had the Warrant been exercised  immediately prior to such action.  Any such
agreements  referred to in this subsection shall provide for adjustments,  which
shall be as nearly equivalent as may be practicable to the adjustments  provided
for in this Section.  The provisions of this subsection shall similarly apply to
successive Mergers or Sales.

                           (b) Notwithstanding the foregoing provisions,  if the
surviving,  successor or purchasing corporation does not agree to the provisions
set forth in  paragraph  (a) above,  or if the Board of Directors of the Company
determines that the Warrants should not be outstanding following consummation of
such  Merger  or  Sale,  then  the  Company  shall  deliver  a  notice  to  each
Warrantholder  at least 20 days before the  consummation of such Merger or Sale,
the  Warrantholder  may exercise the Warrant at any time before the consummation
of such  Merger or Sale  (and  such  exercise  may be made  contingent  upon the
consummation  of such Merger or Sale),  and any portion of the Warrant  that has
not been exercised  before  consummation  of such Merger or Sale shall terminate
and expire, and shall no longer be outstanding.

                  7.4 Independent Public  Accountants.  The Company may retain a
firm of independent  public  accountants of recognized  national standing (which
may be any such firm regularly  employed by the Company) to make any computation
required  under this  Section,  and a  certificate  signed by such firm shall be
conclusive  evidence  of the  correctness  of any  computation  made  under this
Section.

                  7.5  Statement on Warrant  Certificates.  Irrespective  of any
adjustments  in the number of securities  issuable upon exercise of the Warrant,
the  Warrant  certificates  theretofore  or  thereafter  issued may  continue to
express  the same  number of  securities  as are stated in the  similar  Warrant
certificate initially issued.  However, the Company may, at any time in its sole
discretion



                                      -6-
<PAGE>

(which shall be conclusive),  make any change in the form of Warrant certificate
that it may deem appropriate and that does not affect the substance thereof; and
any Warrant certificate thereafter issued, whether upon registration of transfer
of, or in exchange or substitution for, an outstanding Warrant certificate,  may
be in the form so changed.

         Section 8. Fractional Interests.

         The Company  shall not be required  to issue  fractional  Shares on the
exercise  of the  Warrant.  If any  fraction  of a Share  would,  except for the
provisions  of this  Section,  be  issuable  on the  exercise of the Warrant (or
specified portion thereof), the Company shall pay an amount in cash equal to the
then fair market value of a share of Common Stock (as  determined  in good faith
by the Board of Directors of the Company) multiplied by such fraction.

         Section 9. No Rights as Shareholder; Notices to Warrantholder.

         Nothing contained in this Warrant shall be construed as conferring upon
the Warrantholder or its transferees any rights as a shareholder of the Company,
including the right to vote, receive dividends,  consent or receive notices as a
shareholder  in  respect of any  meeting of  shareholders  for the  election  of
directors of the Company or any other matter.


         Section 10. Restrictions on Transfer.

         The  Warrantholder  agrees  that  prior to making  any sale,  transfer,
pledge, assignment,  hypothecation, or other disposition (each, a "Transfer") of
the  Warrant or Shares,  the  Warrantholder  shall  give  written  notice to the
Company  describing the manner in which any such proposed Transfer is to be made
and providing such additional  information regarding the Transfer as the Company
reasonably requests. If the Company so requests,  the Warrantholder shall at its
expense  provide the Company with an opinion of counsel  (which  counsel must be
reasonably  satisfactory  to the Company) to the holder,  in form and  substance
satisfactory to the Company, that the proposed Transfer complies with applicable
federal and state  securities  laws.  The Company  shall have no  obligation  to
Transfer  any  Securities  unless  the  holder  thereof  has  complied  with the
foregoing provisions, and any such attempted Transfer shall be null and void.


         Section 11. Certain Representations and Warranties of Warrantholder.

         Warrantholder represents and warrants to, and agrees with, the Company,
that:

                  (a) Purchase for Own Account.  This Warrant and the Shares are
being acquired for investment for Warrantholder's own account,  not as a nominee
or  agent,  and not with a view to the  public  resale or  distribution  thereof
within the meaning of the Act, and such  Warrantholder  has no present intention
of selling, granting any participation in, or otherwise distributing the same.

                                      -7-
<PAGE>

                  (b) Disclosure of Information.  Warrantholder  has received or
has had full access to all the information it considers necessary or appropriate
to  make  an  informed   investment   decision  with  respect  to  the  Warrant.
Warrantholder  has had an opportunity to ask questions and receive  answers from
the Company regarding the terms and conditions of the Warrant and the Shares and
to obtain additional  information  necessary to verify any information furnished
to Warrantholder or to which Warrantholder had access.

                  (c) Investment Experience.  Warrantholder understands that the
receipt of the Warrants and the purchase of the Shares involve substantial risk.
Warrantholder:  (i) has  experience as an investor in securities of companies in
the development stage and acknowledges  that it is able to fend for itself,  can
bear the  economic  risk of such  investment  in the Warrants and Shares and has
such   knowledge  and   experience   in  financial  or  business   matters  that
Warrantholder  is capable of evaluating the merits and risks of this  investment
in the Warrants and Shares and protecting his or her own interests in connection
with  this  investment  and/or  (ii)  has a  preexisting  personal  or  business
relationship  with  the  Company  and  certain  of its  officers,  directors  or
controlling  persons of a nature and duration that enables  Warrantholder  to be
aware of the  character,  business  acumen and financial  circumstances  of such
persons.

                  (d) Restricted Securities.  Warrantholder understands that the
Warrants and the Shares are  characterized as "restricted  securities" under the
Act inasmuch as they are being  acquired from the Company in a  transaction  not
involving a public  offering and that under the Act and  applicable  regulations
thereunder such securities may be resold without registration under the Act only
in certain limited circumstances.  In this connection,  Warrantholder represents
that  Warrantholder  is familiar  with Rule 144 of the  Securities  and Exchange
Commission,  as  presently in effect,  and  understands  the resale  limitations
imposed thereby and by the Securities Act.  Warrantholder  understands  that the
Company is under no obligation to register any of the securities  sold hereunder
except as provided in Section 12 below.

                  (e) Further  Limitations  on  Disposition.  Without in any way
limiting the representations set forth above,  Warrantholder  further agrees not
to make any  disposition  of the  Warrant  or all or any  portion  of the Shares
unless and until:

                           (i) there is then in effect a registration  statement
under the Act covering such proposed disposition and such disposition is made in
accordance with such registration statement; or

                           (ii)  (A)  Warrantholder   shall  have  notified  the
Company of the proposed  disposition and shall have furnished the Company with a
statement of the circumstances  surrounding the proposed  disposition,  and (ii)
Warrantholder  shall have furnished the Company, at the expense of Warrantholder
or its transferee,  with an opinion of counsel,  reasonably  satisfactory to the
Company,  that such disposition will not require registration of such securities
under the Act.

Notwithstanding  the  provisions  of  paragraphs  (i) and  (ii)  above,  no such
registration  statement  or opinion of counsel  shall be  required:  (1) for any
transfer of any Shares in  compliance  with SEC



                                      -8-
<PAGE>

Rule  144 or (2) for the  transfer  by gift,  will or  intestate  succession  by
Warrantholder  to his or her spouse or lineal  descendants  or  ancestors or any
trust for any of the foregoing; provided that in each of the foregoing cases the
transferee  agrees in writing  to be subject to the terms of this  Section 11 to
the same extent as if the transferee were the original Warrantholder.

                  (f) Legends. It is understood that the certificates evidencing
the Warrant Shares will bear the legends set forth below:

                           (i)  THE  SECURITIES   REPRESENTED  BY  THIS  WARRANT
CERTIFICATE  HAVE NOT BEEN  REGISTERED  UNDER  THE  SECURITIES  ACT OF 1933 (THE
"ACT") OR ANY STATE  SECURITIES  LAWS AND MAY NOT BE SOLD,  EXCHANGED,  PLEDGED,
HYPOTHECATED  OR TRANSFERRED  IN ANY MANNER (A "TRANSFER")  EXCEPT IN COMPLIANCE
WITH THE TERMS OF THIS WARRANT, THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS
OR THE COMPANY RECEIVES AN OPINION OF COUNSEL FOR THE HOLDER OF THESE SECURITIES
SATISFACTORY  TO THE  COMPANY,  STATING  THAT SUCH  TRANSFER  IS EXEMPT FROM THE
REGISTRATION AND PROSPECTUS  DELIVERY  REQUIREMENTS OF THE ACT AND COMPLIES WITH
APPLICABLE STATE SECURITIES LAWS.

                           (ii) Any legend  required by the laws of the State of
California:

The legend  set forth in (i) above  shall be  removed  by the  Company  from any
certificate  evidencing  Shares  upon  delivery  to the Company of an opinion by
counsel,  reasonably  satisfactory to the Company, that a registration statement
under the Act is at that time in effect with respect to the legended security or
that such  security  can be freely  transferred  in a public sale without such a
registration  statement  being  in  effect  and  that  such  transfer  will  not
jeopardize the exemption or exemptions from  registration  pursuant to which the
Company issued the Shares.


         Section 12. Registration Rights.

         The Company will use all  reasonable  efforts to  register,  either the
issuance of shares of Common Stock  issuable upon exercise of the Warrant or the
resale of such shares.  The  Warrantholder  agrees to cooperate with the Company
and provide such  information as the Company  reasonably  requests in connection
with such registration.


         Section 13. Miscellaneous.

                                      -9-
<PAGE>


                  13.1  Notices.  Any  notice  pursuant  to this  Warrant by the
Company or by a  Warrantholder  or a holder of Shares  shall be in  writing  and
shall be  deemed to have been duly  given if  delivered  or mailed by  certified
mail, return receipt requested:

                  (a) If to a Warrantholder or a holder of Shares,  addressed to
the  holder's  address  on the books of the  Company or the  Company's  transfer
agent; and

                  (b)  If to  the  Company  addressed  to it  at  the  Company's
principal executive offices, Attention: President.

         Each party may from time to time change the address to which notices to
it are to be delivered or mailed  hereunder by notice in accordance  herewith to
the other party.

                  13.2  Successors.  All the  covenants  and  provisions of this
Warrant by or for the benefit of the Company, the Warrantholder,  or the holders
of Shares,  shall bind and inure to the benefit of their  respective  successors
and assigns hereunder.

                  13.3 Applicable  Law;  Consent to  Jurisdiction.  This Warrant
shall be governed by and construed in  accordance  with the laws of the State of
California,  without  giving  effect to the  choice of law or  conflict  of laws
principles thereof.  Warrantholder and the Company each consent to the exclusive
jurisdiction  and venue of the federal and state court in the  district in which
the Company's  principal  executive offices are then-located for purposes of any
action  arising out of or relating to this  Warrant,  and agrees that service of
process in any such action may be effected by means of the  procedures set forth
in Section 13.1 above for giving notices under this Warrant.

                  13.4 Benefits of this  Warrant.  Nothing in this Warrant shall
be construed to give to any person or  corporation  other than the Company,  the
Warrantholder and the holders of Shares, any legal or equitable right, remedy or
claim under this  Warrant,  and this Warrant shall be for the sole and exclusive
benefit of the Company, the Warrantholder and the holders of Shares.

                  13.5  Amendment.  Neither this Warrant nor any term hereof may
be amended, waived,  discharged or terminated other than by a written instrument
signed by the party  against whom  enforcement  of any such  amendment,  waiver,
discharge or termination is sought.

                  13.6 Entire Agreement.  This Warrant  constitutes the full and
entire  understanding  and  agreement  between  the  parties  with regard to the
subject matter hereof, and no party shall be liable or bound to any other in any
manner by any representations,  warranties,  covenants, and agreements except as
specifically set forth herein and therein. Nothing in this Warrant, expressed or
implied,  is intended to confer upon any party,  other than the parties  hereto,
and their respective successors and assigns, any rights, remedies,  obligations,
or liabilities under or by reason of this Warrant,  except as expressly provided
herein.

                  13.7 Separability.  Any invalidity,  illegality, or limitation
of the  enforceability  with  respect  to any  party  of any  one or more of the
provisions of this Warrant,  or any part thereof,  whether  arising by reason of
the law of any such  party's  domicile or  otherwise,  shall in no way


                                      -10-
<PAGE>

affect or impair the validity,  legality, or enforceability of this Warrant with
respect to all other  parties.  In case any  provision of this Warrant  shall be
invalid, illegal, or unenforceable,  the validity,  legality, and enforceability
of the  remaining  provisions  shall  not in any  way be  affected  or  impaired
thereby.

                  13.8 Counterparts.  This Warrant may be executed in any number
of counterparts,  each of which shall be an original,  but all of which together
shall constitute one instrument.

                  [Remainder of this page intentionally left blank]




                                      -11-
<PAGE>

         IN WITNESS  WHEREOF,  the Company  has caused  this  Warrant to be duly
executed, all as of the day and year first above written.



                                              CELLEGY PHARMACEUTICALS, INC.



                                              By:
                                                  ------------------------------
                                                    A. Richard Juelis
                                                    Chief Financial Officer



                                              Attest:



                                              ------------------------------



                                      -12-



                                                                     EXHIBIT 4.3

THE SECURITIES  REPRESENTED BY THIS WARRANT CERTIFICATE HAVE NOT BEEN REGISTERED
UNDER THE  SECURITIES ACT OF 1933 (THE "ACT") OR ANY STATE  SECURITIES  LAWS AND
MAY NOT BE SOLD, EXCHANGED,  PLEDGED,  HYPOTHECATED OR TRANSFERRED IN ANY MANNER
(A "TRANSFER") EXCEPT IN COMPLIANCE WITH THE TERMS OF THIS WARRANT,  THE ACT AND
ANY  APPLICABLE  STATE  SECURITIES  LAWS OR THE  COMPANY  RECEIVES AN OPINION OF
COUNSEL FOR THE HOLDER OF THESE SECURITIES SATISFACTORY TO THE COMPANY,  STATING
THAT SUCH  TRANSFER  IS EXEMPT FROM THE  REGISTRATION  AND  PROSPECTUS  DELIVERY
REQUIREMENTS OF THE ACT AND COMPLIES WITH APPLICABLE STATE SECURITIES LAWS.




                                                     Warrant Certificate No. 408


                               WARRANT TO PURCHASE
                             SHARES OF COMMON STOCK
                          CELLEGY PHARMACEUTICALS, INC.

THIS  WARRANT (the  "Warrant")  is dated as of January 19, 1999 and is issued by
Cellegy  Pharmaceuticals,  Inc., a California  corporation (the  "Company"),  to
Richard Bank, M.D.  ("Warrantholder"),  in the amount of up to 12,000  Warrants,
subject to the  completion of the six-month  consulting  engagement  between the
Company and Dr. Bank.

         Section 1.  Definitions

                  1.1 Definitions.  For purposes of this Warrant,  the following
terms shall have the following meanings.

                  "Act" shall mean the Securities Act of 1933, as amended.

                  "Common Stock" means the Company's Common Stock, no par value.

                  "Exercise Price" has the meaning given to that term in Section
2.2.

                  "Merger or Sale" shall have the meaning  given to that term in
Section 7.3.

                  "Shares"  shall  mean the  shares of Common  Stock that can be
acquired upon exercise of the Warrant.

                  "Termination Date" shall mean the date on which the Warrant is
no longer  exercisable,  which  date  shall be January  19,  2001,  or sooner as
provided in this Warrant,  including  without  limitation,  in connection with a
merger or sale of the Company.
<PAGE>

                  "Transfer  Agent"  shall  mean  the  Company's  registrar  and
transfer agent, if any, for the Warrant.

                  "Warrant" shall mean this Warrant to purchase shares of Common
Stock.  The term "Warrant" shall include any Warrant  evidenced by a certificate
or  certificates  issued  upon  division,  exchange,  substitution  or  transfer
pursuant to the terms of this Warrant.


         Section 2. Issuance of Warrant; Form of Warrant.

                  2.1 Issuance. In consideration of the Warrantholder's services
on behalf of the  Company in the areas  identified  in Exhibit A  attached,  the
Company  hereby issues the Warrant to the  Warrantholder  to purchase a total of
12,000 shares of Common Stock issuable in increments of 2,000 Warrants per month
beginning  with the Warrant date (January 19, 1999) and ending on July 19, 1999.
If Dr. Bank and Cellegy mtually agree to discontinue  the consulting  engagement
earlier than the end of the six-month  period,  then remaining  monthly  warrant
grants will be discontinued.

                  2.2  Exercise  Price and  Exercise  Conditions.  The price per
share at which shares  shall be  purchasable  upon  exercise of the Warrant (the
"Exercise Price") is $4.00 per share.

                  2.3  Registration.  The Warrant shall be numbered and shall be
registered on the books of the Company.

                  2.4 Transfer.  The Warrant may not be  transferred,  except to
members of the Warrantholder's immediate family or trusts for the benefit of the
Warrantholder or one or more members of the Warrantholder's immediate family. To
the extent that the Warrant is  transferable,  the Warrant shall be transferable
only on the books of the Company maintained at its principal office in South San
Francisco,  California  or, if the  Company  has a Transfer  Agent,  then at the
offices of the  Transfer  Agent,  upon  delivery  thereof  duly  endorsed by the
Warrantholder or by its duly authorized attorney or representative,  accompanied
by proper evidence of succession,  assignment or authority to transfer. Upon any
registration of transfer, the Company shall execute and deliver a new Warrant to
the person entitled thereto.

                  2.5 Certificates. The Warrant may be divided or combined, upon
request to the Company by the Warrantholder,  into a certificate or certificates
representing the right to purchase the same aggregate  number of Shares.  Unless
the context  indicates  otherwise,  the term  "Warrantholder"  shall include any
transferee or transferees of the Warrant.

                  2.6 Signatures. The number of Shares issuable upon exercise of
the Warrant is subject to adjustment upon the occurrence of certain events,  all
as hereinafter provided.  The Warrant shall be executed on behalf of the Company
by its  President or by a Vice  President and attested to by its Secretary or an
Assistant Secretary. A Warrant bearing the signature of an individual who was at
any  time  the  proper   officer  of  the  Company   shall  bind  the   Company,
notwithstanding that such individual shall have ceased to hold such office prior
to the  delivery of such Warrant or did not hold such office on the date of this
Warrant.

                                      -2-
<PAGE>

                  2.7 Legends on Certificate.  Each certificate representing the
Warrant,  and for Shares  initially  issued upon exercise of the Warrant,  shall
bear the following  legends,  unless,  at the time of exercise,  such Shares are
subject to a currently effective Registration Statement under the Act:

                           (a)  THE  SECURITIES   REPRESENTED  BY  THIS  WARRANT
CERTIFICATE  HAVE NOT BEEN  REGISTERED  UNDER  THE  SECURITIES  ACT OF 1933 (THE
"ACT") OR ANY STATE  SECURITIES  LAWS AND MAY NOT BE SOLD,  EXCHANGED,  PLEDGED,
HYPOTHECATED  OR TRANSFERRED  IN ANY MANNER (A "TRANSFER")  EXCEPT IN COMPLIANCE
WITH THE TERMS OF THIS WARRANT, THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS
OR THE COMPANY RECEIVES AN OPINION OF COUNSEL FOR THE HOLDER OF THESE SECURITIES
SATISFACTORY  TO THE  COMPANY,  STATING  THAT SUCH  TRANSFER  IS EXEMPT FROM THE
REGISTRATION AND PROSPECTUS  DELIVERY  REQUIREMENTS OF THE ACT AND COMPLIES WITH
APPLICABLE STATE SECURITIES LAWS.

                           (b)  Any  legend   required   by   applicable   state
securities laws.

                  Any certificate issued at any time in exchange or substitution
for any certificate  bearing such legends (except a new certificate  issued upon
completion of a public distribution  pursuant to a registration  statement under
the Act of the securities represented thereby) shall also bear the above legends
unless,  in the opinion of the Company's  counsel,  the  securities  represented
thereby need no longer be subject to such restrictions.

                  2.8 Exchange of Warrant  Certificate.  Any Warrant certificate
may  be  exchanged  for  another  certificate  or  certificates   entitling  the
Warrantholder  to purchase a like aggregate  number of Shares as the certificate
or certificates  surrendered then entitled such  Warrantholder to purchase.  Any
Warrantholder desiring to exchange a Warrant certificate shall make such request
in writing  delivered to the Company,  and shall surrender,  properly  endorsed,
with  signatures   guaranteed  if  required  by  the  Company,  the  certificate
evidencing the Warrant to be so exchanged.  Thereupon, the Company shall execute
and  deliver to the person  entitled  thereto a new  Warrant  certificate  as so
requested.

         Section 3. Term of Warrant; Exercise of Warrant.

                  3.1  Term.   Subject  to  the  terms  of  this  Warrant,   the
Warrantholder  shall have the right,  at any time after the date of this Warrant
and ending at 5:00 p.m.,  California  Time, on the Termination  Date to purchase
from the  Company  up to the number of fully  paid and  nonassessable  Shares to
which the Warrantholder may at the time be entitled to purchase pursuant to this
Warrant,  upon  surrender  to the  Company,  at  its  principal  office,  of the
certificate  evidencing the Warrant to be exercised,  together with the purchase
form, duly filled in and signed,  with signatures  guaranteed if required by the
Company or its Transfer  Agent,  and upon payment to the Company of the Exercise
Price  for the  number  of  Shares  in  respect  of which  the  Warrant  is then
exercised,  but in no event  for less  than 100  Shares  (unless  fewer  than an
aggregate  of  100  Shares  are  then  purchasable  pursuant  to  the  Warrant).
Notwithstanding the foregoing, the



                                      -3-
<PAGE>

Company shall not be obligated to deliver any Shares pursuant to the exercise of
the  Warrant,  and the  Warrantholder  shall not have the right to exercise  the
Warrant, if in the Company's opinion the delivery of Shares upon exercise of the
Warrant would not comply with any applicable  federal or state  securities laws;
and without  limiting the  foregoing,  the Warrant may not be  exercised  by, or
securities  issued to,  any  Warrantholder  in any state in which such  exercise
would be unlawful.

                  3.2  Payment  of  Exercise  Price.  Payment  of the  aggregate
Exercise Price shall be made in cash or by check, or any combination thereof.

                  3.3  Issuance  of  Certificate.  Upon  such  surrender  of the
Warrant and payment of such Exercise Price, the Company shall issue and cause to
be delivered to the Warrantholder and in the Warrantholder's name, a certificate
or certificates  for the number of full Shares so purchased upon the exercise of
the  Warrant,  together  with  cash,  as  provided  herein,  in  respect  of any
fractional  Share otherwise  issuable upon such surrender.  Such  certificate or
certificates shall be deemed to have been issued and any person so designated to
be named  therein  shall be  deemed  to have  become a holder  of record of such
securities  as of the  date of  surrender  of the  Warrant  and  payment  of the
Exercise   Price,  as  aforesaid,   notwithstanding   that  the  certificate  or
certificates   representing   such  securities  shall  not  actually  have  been
delivered.   The  Warrant  shall  be   exercisable,   at  the  election  of  the
Warrantholder,  either in full or from  time to time in part  and,  in the event
that a certificate  evidencing  the Warrant is exercised in respect of less than
all of the Shares specified therein at any time prior to the Termination Date, a
new certificate  evidencing the remaining  portion of the Warrant will be issued
by the Company.

         Section 4. Payment of Taxes.

         The Company will pay all documentary stamp taxes, if any,  attributable
to the initial issuance of the Warrant or the securities  comprising the Shares;
provided, however, the Company shall not be required to pay any tax which may be
payable in respect of any transfer of the Warrant or the  securities  comprising
the Shares.

         Section 5. Mutilated or Missing Warrants.

         In case the certificate or certificates evidencing the Warrant shall be
mutilated,  lost, stolen or destroyed,  the Company shall, at the request of the
Warrantholder,  issue and  deliver in  exchange  and  substitution  for and upon
cancellation  of the mutilated  certificate or  certificates,  or in lieu of and
substitution for the certificate or certificates  lost,  stolen or destroyed,  a
new  Warrant  certificate  or  certificates  of like tenor and  representing  an
equivalent right or interest,  but only upon receipt of evidence satisfactory to
the Company of such loss,  theft or  destruction  of such  Warrant and a bond of
indemnity,  if  requested,   also  satisfactory  in  form  and  amount,  at  the
applicant's cost.  Applicants for such substitute Warrant certificate shall also
comply  with such other  reasonable  regulations  and pay such other  reasonable
charges as the Company may prescribe.

         Section 6. Reservation of Shares.

                                      -4-
<PAGE>

         There  has been  reserved,  and the  Company  shall at all  times  keep
reserved so long as the Warrant remains  outstanding,  out of its authorized and
unissued Common Stock, such number of shares of Common Stock as shall be subject
to purchase under the Warrant.

         Section 7. Adjustment of Number of Shares.

         The number and kind of securities  purchasable upon the exercise of the
Warrant and the Exercise Price shall be subject to adjustment  from time to time
upon the happening of certain events, as follows:

                  7.1  Adjustments.  The number of Shares  purchasable  upon the
exercise of the Warrant shall be subject to adjustment as follows:

                           (a)  Stock  Splits;  Stock  Dividends.  In  case  the
Company shall (i) pay a dividend in Common Stock, (ii) subdivide its outstanding
Common Stock,  (iii) combine its outstanding  Common Stock into a smaller number
of shares of Common Stock,  including without  limitation any combination of its
outstanding Common Stock that may occur after January 19, 1999, or (iv) issue by
reclassification  of its Common Stock other securities of the Company,  then the
number of Shares  purchasable  upon  exercise of the Warrant  immediately  prior
thereto shall be adjusted so that the Warrantholder shall be entitled to receive
upon  exercise of the Warrant the kind and number of Shares or other  securities
of the Company  which it would have owned or would have been entitled to receive
immediately  after the happening of any of the events  described  above, had the
Warrant been exercised  immediately  prior to the happening of such event or any
record  date  with  respect  thereto.  Any  adjustment  made  pursuant  to  this
subsection shall become effective  immediately  after the effective date of such
event, retroactive to the record date, if any, for such event.

                           (b) De Minimis  Changes.  No adjustment in the number
of Shares  purchasable  pursuant  to the Warrant  shall be required  unless such
adjustment  would require an increase or decrease of at least one percent in the
number of Shares then purchasable upon the exercise of all Commitment  Warrants;
provided,  however,  that any adjustments which by reason of this subsection are
not  required  to be made  immediately  shall be carried  forward and taken into
account in any subsequent adjustment.

                           (c)  Corresponding   Adjustment  of  Exercise  Price.
Whenever  the number of Shares  purchasable  upon the exercise of the Warrant is
adjusted,  as herein  provided,  the Exercise Price payable upon exercise of the
Warrant shall be adjusted by multiplying such Exercise Price  immediately  prior
to such adjustment by a fraction,  the numerator of which shall be the number of
Shares  purchasable upon the exercise of the Warrant  immediately  prior to such
adjustment,  and the  denominator  of which  shall be the  number  of  Shares so
purchasable immediately thereafter.

                           (d)  Notice of  Adjustment.  Whenever  the  number of
Shares  purchasable  upon the  exercise  of the  Warrant is  adjusted  as herein
provided,  the Company  shall cause to be mailed to the  Warrantholder  within a
reasonable time thereafter notice of such adjustment setting forth the number of
Shares  purchasable  upon the exercise of the Warrant after



                                      -5-
<PAGE>

such  adjustment,  a brief  statement of the facts requiring such adjustment and
the computation by which such adjustment was made.

                  7.2  No  Adjustment  for  Dividends.  Except  as  provided  in
subsection  7.1(a),  no adjustment in respect of any dividends or  distributions
out of  earnings  shall  be made  during  the  term of the  Warrant  or upon the
exercise of the Warrant.

                  7.3  Preservation  of Purchase  Rights upon  Reclassification,
Consolidation, etc.

                           (a) Subject to paragraph (b) of this Section, in case
of any  consolidation  of the Company with or merger of the Company into another
corporation where the Company will not be the surviving corporation,  or in case
of any sale or conveyance  to another  corporation  of the  property,  assets or
business of the Company as an entirety or substantially as an entirety (any such
event  referred  to as a "Merger or Sale"),  the  Company or such  successor  or
purchasing  corporation,  as the case may be, shall agree that the Warrantholder
shall have the right  thereafter  upon payment of the  Exercise  Price in effect
immediately prior to such action to purchase,  upon exercise of the Warrant, the
kind and amount of shares and other  securities and property which it would have
owned or have been  entitled to receive  after the  happening  of such Merger or
Sale had the Warrant been exercised  immediately prior to such action.  Any such
agreements  referred to in this subsection shall provide for adjustments,  which
shall be as nearly equivalent as may be practicable to the adjustments  provided
for in this Section.  The provisions of this subsection shall similarly apply to
successive Mergers or Sales.

                           (b) Notwithstanding the foregoing provisions,  if the
surviving,  successor or purchasing corporation does not agree to the provisions
set forth in  paragraph  (a) above,  or if the Board of Directors of the Company
determines that the Warrants should not be outstanding following consummation of
such  Merger  or  Sale,  then  the  Company  shall  deliver  a  notice  to  each
Warrantholder  at least 20 days before the  consummation of such Merger or Sale,
the  Warrantholder  may exercise the Warrant at any time before the consummation
of such  Merger or Sale  (and  such  exercise  may be made  contingent  upon the
consummation  of such Merger or Sale),  and any portion of the Warrant  that has
not been exercised  before  consummation  of such Merger or Sale shall terminate
and expire, and shall no longer be outstanding.

                  7.4 Independent Public  Accountants.  The Company may retain a
firm of independent  public  accountants of recognized  national standing (which
may be any such firm regularly  employed by the Company) to make any computation
required  under this  Section,  and a  certificate  signed by such firm shall be
conclusive  evidence  of the  correctness  of any  computation  made  under this
Section.

                  7.5  Statement on Warrant  Certificates.  Irrespective  of any
adjustments  in the number of securities  issuable upon exercise of the Warrant,
the  Warrant  certificates  theretofore  or  thereafter  issued may  continue to
express  the same  number of  securities  as are stated in the  similar  Warrant
certificate initially issued.  However, the Company may, at any time in its sole
discretion  (which shall be conclusive),  make any change in the form of Warrant
certificate  that it may deem appropriate and that does not affect the substance
thereof;   and  any  Warrant   certificate   thereafter



                                      -6-
<PAGE>

issued, whether upon registration of transfer of, or in exchange or substitution
for, an outstanding Warrant certificate, may be in the form so changed.

         Section 8. Fractional Interests.

         The Company  shall not be required  to issue  fractional  Shares on the
exercise  of the  Warrant.  If any  fraction  of a Share  would,  except for the
provisions  of this  Section,  be  issuable  on the  exercise of the Warrant (or
specified portion thereof), the Company shall pay an amount in cash equal to the
then fair market value of a share of Common Stock (as  determined  in good faith
by the Board of Directors of the Company) multiplied by such fraction.

         Section 9. No Rights as Shareholder; Notices to Warrantholder.

         Nothing contained in this Warrant shall be construed as conferring upon
the Warrantholder or its transferees any rights as a shareholder of the Company,
including the right to vote, receive dividends,  consent or receive notices as a
shareholder  in  respect of any  meeting of  shareholders  for the  election  of
directors of the Company or any other matter.


         Section 10. Restrictions on Transfer.

         The  Warrantholder  agrees  that  prior to making  any sale,  transfer,
pledge, assignment,  hypothecation, or other disposition (each, a "Transfer") of
the  Warrant or Shares,  the  Warrantholder  shall  give  written  notice to the
Company  describing the manner in which any such proposed Transfer is to be made
and providing such additional  information regarding the Transfer as the Company
reasonably requests. If the Company so requests,  the Warrantholder shall at its
expense  provide the Company with an opinion of counsel  (which  counsel must be
reasonably  satisfactory  to the Company) to the holder,  in form and  substance
satisfactory to the Company, that the proposed Transfer complies with applicable
federal and state  securities  laws.  The Company  shall have no  obligation  to
Transfer  any  Securities  unless  the  holder  thereof  has  complied  with the
foregoing provisions, and any such attempted Transfer shall be null and void.


         Section 11. Certain Representations and Warranties of Warrantholder.

         Warrantholder represents and warrants to, and agrees with, the Company,
that:

                  (a) Purchase for Own Account.  This Warrant and the Shares are
being acquired for investment for Warrantholder's own account,  not as a nominee
or  agent,  and not with a view to the  public  resale or  distribution  thereof
within the meaning of the Act, and such  Warrantholder  has no present intention
of selling, granting any participation in, or otherwise distributing the same.

                                      -7-
<PAGE>

                  (b) Disclosure of Information.  Warrantholder  has received or
has had full access to all the information it considers necessary or appropriate
to  make  an  informed   investment   decision  with  respect  to  the  Warrant.
Warrantholder  has had an opportunity to ask questions and receive  answers from
the Company regarding the terms and conditions of the Warrant and the Shares and
to obtain additional  information  necessary to verify any information furnished
to Warrantholder or to which Warrantholder had access.

                  (c) Investment Experience.  Warrantholder understands that the
receipt of the Warrants and the purchase of the Shares involve substantial risk.
Warrantholder:  (i) has  experience as an investor in securities of companies in
the development stage and acknowledges  that it is able to fend for itself,  can
bear the  economic  risk of such  investment  in the Warrants and Shares and has
such   knowledge  and   experience   in  financial  or  business   matters  that
Warrantholder  is capable of evaluating the merits and risks of this  investment
in the Warrants and Shares and protecting his or her own interests in connection
with  this  investment  and/or  (ii)  has a  preexisting  personal  or  business
relationship  with  the  Company  and  certain  of its  officers,  directors  or
controlling  persons of a nature and duration that enables  Warrantholder  to be
aware of the  character,  business  acumen and financial  circumstances  of such
persons.

                  (d) Restricted Securities.  Warrantholder understands that the
Warrants and the Shares are  characterized as "restricted  securities" under the
Act inasmuch as they are being  acquired from the Company in a  transaction  not
involving a public  offering and that under the Act and  applicable  regulations
thereunder such securities may be resold without registration under the Act only
in certain limited circumstances.  In this connection,  Warrantholder represents
that  Warrantholder  is familiar  with Rule 144 of the  Securities  and Exchange
Commission,  as  presently in effect,  and  understands  the resale  limitations
imposed thereby and by the Securities Act.  Warrantholder  understands  that the
Company is under no obligation to register any of the securities  sold hereunder
except as provided in Section 12 below.

                  (e) Further  Limitations  on  Disposition.  Without in any way
limiting the representations set forth above,  Warrantholder  further agrees not
to make any  disposition  of the  Warrant  or all or any  portion  of the Shares
unless and until:

                           (i) there is then in effect a registration  statement
under the Act covering such proposed disposition and such disposition is made in
accordance with such registration statement; or

                           (ii)  (A)  Warrantholder   shall  have  notified  the
Company of the proposed  disposition and shall have furnished the Company with a
statement of the circumstances  surrounding the proposed  disposition,  and (ii)
Warrantholder  shall have furnished the Company, at the expense of Warrantholder
or its transferee,  with an opinion of counsel,  reasonably  satisfactory to the
Company,  that such disposition will not require registration of such securities
under the Act.

Notwithstanding  the  provisions  of  paragraphs  (i) and  (ii)  above,  no such
registration  statement  or opinion of counsel  shall be  required:  (1) for any
transfer of any Shares in  compliance  with SEC Rule 144 or (2) for the transfer
by gift, will or intestate  succession by  Warrantholder to his or her



                                      -8-
<PAGE>

spouse or lineal descendants or ancestors or any trust for any of the foregoing;
provided that in each of the foregoing cases the transferee agrees in writing to
be  subject  to the  terms  of this  Section  11 to the  same  extent  as if the
transferee were the original Warrantholder.

                  (f) Legends. It is understood that the certificates evidencing
the Warrant Shares will bear the legends set forth below:

                           (i)  THE  SECURITIES   REPRESENTED  BY  THIS  WARRANT
CERTIFICATE  HAVE NOT BEEN  REGISTERED  UNDER  THE  SECURITIES  ACT OF 1933 (THE
"ACT") OR ANY STATE  SECURITIES  LAWS AND MAY NOT BE SOLD,  EXCHANGED,  PLEDGED,
HYPOTHECATED  OR TRANSFERRED  IN ANY MANNER (A "TRANSFER")  EXCEPT IN COMPLIANCE
WITH THE TERMS OF THIS WARRANT, THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS
OR THE COMPANY RECEIVES AN OPINION OF COUNSEL FOR THE HOLDER OF THESE SECURITIES
SATISFACTORY  TO THE  COMPANY,  STATING  THAT SUCH  TRANSFER  IS EXEMPT FROM THE
REGISTRATION AND PROSPECTUS  DELIVERY  REQUIREMENTS OF THE ACT AND COMPLIES WITH
APPLICABLE STATE SECURITIES LAWS.


                           (ii) Any legend  required by the laws of the State of
California:

The legend  set forth in (i) above  shall be  removed  by the  Company  from any
certificate  evidencing  Shares  upon  delivery  to the Company of an opinion by
counsel,  reasonably  satisfactory to the Company, that a registration statement
under the Act is at that time in effect with respect to the legended security or
that such  security  can be freely  transferred  in a public sale without such a
registration  statement  being  in  effect  and  that  such  transfer  will  not
jeopardize the exemption or exemptions from  registration  pursuant to which the
Company issued the Shares.


         Section 12. Registration Rights.

         The Company will use all  reasonable  efforts to  register,  either the
issuance of shares of Common Stock  issuable upon exercise of the Warrant or the
resale of such shares.  The  Warrantholder  agrees to cooperate with the Company
and provide such  information as the Company  reasonably  requests in connection
with such registration.


         Section 13. Miscellaneous.

                  13.1  Notices.  Any  notice  pursuant  to this  Warrant by the
Company or by a  Warrantholder  or a holder of Shares  shall be in  writing  and
shall be  deemed to have been duly  given if  delivered  or mailed by  certified
mail, return receipt requested:

                                      -9-
<PAGE>

                  (a) If to a Warrantholder or a holder of Shares,  addressed to
the  holder's  address  on the books of the  Company or the  Company's  transfer
agent; and

                  (b)  If to  the  Company  addressed  to it  at  the  Company's
principal executive offices, Attention: President.

         Each party may from time to time change the address to which notices to
it are to be delivered or mailed  hereunder by notice in accordance  herewith to
the other party.

                  13.2  Successors.  All the  covenants  and  provisions of this
Warrant by or for the benefit of the Company, the Warrantholder,  or the holders
of Shares,  shall bind and inure to the benefit of their  respective  successors
and assigns hereunder.

                  13.3 Applicable  Law;  Consent to  Jurisdiction.  This Warrant
shall be governed by and construed in  accordance  with the laws of the State of
California,  without  giving  effect to the  choice of law or  conflict  of laws
principles thereof.  Warrantholder and the Company each consent to the exclusive
jurisdiction  and venue of the federal and state court in the  district in which
the Company's  principal  executive offices are then-located for purposes of any
action  arising out of or relating to this  Warrant,  and agrees that service of
process in any such action may be effected by means of the  procedures set forth
in Section 13.1 above for giving notices under this Warrant.

                  13.4 Benefits of this  Warrant.  Nothing in this Warrant shall
be construed to give to any person or  corporation  other than the Company,  the
Warrantholder and the holders of Shares, any legal or equitable right, remedy or
claim under this  Warrant,  and this Warrant shall be for the sole and exclusive
benefit of the Company, the Warrantholder and the holders of Shares.

                  13.5  Amendment.  Neither this Warrant nor any term hereof may
be amended, waived,  discharged or terminated other than by a written instrument
signed by the party  against whom  enforcement  of any such  amendment,  waiver,
discharge or termination is sought.

                  13.6 Entire Agreement.  This Warrant  constitutes the full and
entire  understanding  and  agreement  between  the  parties  with regard to the
subject matter hereof, and no party shall be liable or bound to any other in any
manner by any representations,  warranties,  covenants, and agreements except as
specifically set forth herein and therein. Nothing in this Warrant, expressed or
implied,  is intended to confer upon any party,  other than the parties  hereto,
and their respective successors and assigns, any rights, remedies,  obligations,
or liabilities under or by reason of this Warrant,  except as expressly provided
herein.

                  13.7 Separability.  Any invalidity,  illegality, or limitation
of the  enforceability  with  respect  to any  party  of any  one or more of the
provisions of this Warrant,  or any part thereof,  whether  arising by reason of
the law of any such  party's  domicile or  otherwise,  shall in no way affect or
impair the validity, legality, or enforceability of this Warrant with respect to
all other  parties.  In case any  provision  of this  Warrant  shall be invalid,
illegal,  or unenforceable,  the



                                      -10-
<PAGE>

validity,  legality, and enforceability of the remaining provisions shall not in
any way be affected or impaired thereby.

                  13.8 Counterparts.  This Warrant may be executed in any number
of counterparts,  each of which shall be an original,  but all of which together
shall constitute one instrument.

                  [Remainder of this page intentionally left blank]




                                      -11-
<PAGE>



         IN WITNESS  WHEREOF,  the Company  has caused  this  Warrant to be duly
executed, all as of the day and year first above written.



                                               CELLEGY PHARMACEUTICALS, INC.



                                               By:
                                                  ------------------------------
                                                       A. Richard Juelis
                                                       Chief Financial Officer



                                               Attest:



                                               ------------------------------




                                      -12-


                                                                     EXHIBIT 5.1



                               [August 30, 1999]



Cellegy Pharmaceuticals, Inc.
349 Oyster Point Boulevard, Suite 200
South San Francisco, CA 94080

Gentlemen/Ladies:

         At your request,  we have examined the  Registration  Statement on Form
S-3 (the  "Registration  Statement")  to be filed by you with the Securities and
Exchange  Commission  (the  "Commission")  on  or  about  August  30,  1999,  in
connection with the  registration  under the Securities Act of 1933, as amended,
for  resale of an  aggregate  of  1,575,000  shares of your  Common  Stock  (the
"Stock"),  all of which will be sold by the  selling  shareholders  named in the
Prospectus   included   within  the   Registration   Statement   (the   "Selling
Shareholders"),  including  1,561,000  shares  that  are  presently  issued  and
outstanding (the "Outstanding  Shares") and 14,000 shares (the "Warrant Shares")
that are issuable upon the exercise of certain warrants (the "Warrants") held by
certain Selling Shareholders. The Outstanding Shares and the Warrant Shares will
be collectively refered to herein as the "Shares".


         In rendering this opinion, we have examined the following:

         (1)      the Registration  Statement (including the Prospectus included
                  therein), together with the Exhibits filed as a part thereof;

         (2)      your  registration   statement  on  Form  8A  filed  with  the
                  Commission  in  connection  with the  Company's  intial public
                  offering in August 1995;

         (3)      the Common Stock Purchase  Agreement,  dated July 30, 1999, by
                  and among the  Company and the  investors  listed on Exhibit A
                  attached thereto;

         (4)      the Common  Stock  Purchase  Warrant,  dated  January 18, 1999
                  between the Company and Michael P. Crowley, Ph.D.;

         (5)      the Common  Stock  Purchase  Warrant,  dated  January 19, 1999
                  between the Company and Richard Bank, M.D.;

         (6)      the minutes of meetings and actions by written  consent of the
                  Board of Directors that are contained in your minute books and
                  that are in our possession  that relate to the issuance of the
                  Outstanding Shares, the Warrants and the Warrant Shares;

         (7)      a Management  Certificate  addressed to us and executed by the
                  Company containing  certain factual and other  representations
                  including,  without  limitation,  information  concerning  the
                  number of  outstanding  shares of Common  Stock and  shares of
                  common stock  issuable upon exercise of  outstanding  options,
                  warrants and similar rights.



<PAGE>

Cellegy Pharmaceuticals, Inc.
August 30, 1999
Page 2


         We have  confirmed  your  eligibility  to use Form S-3 and by telephone
call to the offices of the  Commission,  we have also  confirmed  the  continued
effectiveness of the Company'  registration under the Securities Exchange Act of
1934,  as amended  (the  "Exchange  Act"),  and the timely  filing by you of all
reports  required to be filed by you pursuant to Rules 13, 14 and 15 promulgated
under the Exchange Act.

         In our  examination of documents for purposes of this opinion,  we have
assumed,  and express no opinion as to, the  genuineness  of all  signatures  on
original documents, the authenticity and completeness of all documents submitted
to us as  originals,  the  conformity  to  originals  and  completeness  of  all
documents  submitted to us as copies,  the legal capacity of all natural persons
executing  the  same,  the lack of any  undisclosed  termination,  modification,
waiver or amendment to any  document  reviewed by us and the due  authorization,
execution and delivery of all documents where due  authorization,  execution and
delivery are prerequisites to the effectiveness thereof.

         As to matters of fact relevant to this  opinion,  we have relied solely
upon our  examination  of the  documents  referred to above and have assumed the
current  accuracy  and  completeness  of the  information  obtained  from public
officials  and  records   referred  to  above.   We  have  made  no  independent
investigation or other attempt to verify the accuracy of any of such information
or to determine the  existence or  non-existence  of any other factual  matters;
however,  we are not aware of any facts that would cause us to believe  that the
opinion expressed herein is not accurate.

         We are  admitted to  practice  law in the State of  California,  and we
express no opinion herein with respect to the  application or effect of the laws
of any jurisdiction other than the existing laws of the United States of America
and the State of California.

         In connection with our opinion  expressed  below, we have assumed that,
at or prior to the time of the delivery of any shares of Stock, the Registration
Statement will have been declared effective under the Securities Act of 1933, as
amended,  that the registration  will apply to such shares of Stock and will not
have been modified or rescinded and that there will not have occurred any change
in law affecting the validity or enforceability of such shares of Stock.

         Based upon the foregoing, it is our opinion that the Outstanding Shares
to be sold by the Selling  Stockholders  pursuant to the Registration  Statement
are, and the warrant shares when and if issued upon exercise of the Warrants and
fully paid for as provided in the  Warrants  will be (assuming no change in such
documents or  applicable  law),  legally  issued and  nonassessable  and, to our
knowledge, fully paid.

         We consent to the use of this opinion as an exhibit to the Registration
Statement  and  further  consent  to  all  references  to  us,  if  any,  in the
Registration  Statement,  the  Prospectus  constituting  a part  thereof and any
amendments thereto.


<PAGE>

Cellegy Pharmaceuticals, Inc.
August 30, 1999
Page 3


         This opinion  speaks only as of its date and we assume no obligation to
update this opinion  should  circumstances  change  after the date hereof.  This
opinion is  intended  solely for the your use as an exhibit to the  Registration
Statement for the purpose of the above sale of the Stock and is not to be relied
upon for any other purpose.

                                                     Very truly yours,

                                                     FENWICK & WEST LLP


                                                     By:________________________






                                                                    EXHIBIT 23.1

               CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

We  consent to the  reference  to our firm under the  caption  "Experts"  in the
Registration   Statement  on  Form  S-3  and  related   Prospectus   of  Cellegy
Pharmaceuticals,  Inc. for the  registration  of 1,561,000  shares of its common
stock and 14,000 shares of its common stock  issuable upon exercise of warrants,
and to the  incorporation  by reference  therein of our report dated February 5,
1999, with respect to the financial statements of Cellegy Pharmaceuticals,  Inc.
included in its Annual Report (Form 10-K) for the year ended  December 31, 1998,
filed with the Securities and Exchange Commission.




Palo Alto, California
August 27, 1999







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