CELLEGY PHARMACEUTICALS INC
S-3, EX-4.6, 2000-11-07
PHARMACEUTICAL PREPARATIONS
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                                                                     Exhibit 4.6

THE SECURITIES  REPRESENTED BY THIS WARRANT CERTIFICATE HAVE NOT BEEN REGISTERED
UNDER THE  SECURITIES ACT OF 1933 (THE "ACT") OR ANY STATE  SECURITIES  LAWS AND
MAY NOT BE SOLD, EXCHANGED,  PLEDGED,  HYPOTHECATED OR TRANSFERRED IN ANY MANNER
(A "TRANSFER") EXCEPT IN COMPLIANCE WITH THE TERMS OF THIS WARRANT,  THE ACT AND
ANY  APPLICABLE  STATE  SECURITIES  LAWS OR THE  COMPANY  RECEIVES AN OPINION OF
COUNSEL FOR THE HOLDER OF THESE SECURITIES SATISFACTORY TO THE COMPANY,  STATING
THAT SUCH  TRANSFER  IS EXEMPT FROM THE  REGISTRATION  AND  PROSPECTUS  DELIVERY
REQUIREMENTS OF THE ACT AND COMPLIES WITH APPLICABLE STATE SECURITIES LAWS.

                                                     Warrant Certificate No. 411


                               WARRANT TO PURCHASE
                             SHARES OF COMMON STOCK
                          CELLEGY PHARMACEUTICALS, INC.


THIS WARRANT (the  "Warrant")  is dated as of February 25, 2000 and is issued by
Cellegy Pharmaceuticals, Inc., a California corporation (the "Company"), to Marc
Parham, Ph.D.  ("Warrantholder"),  in the amount of up to 3,500 Warrants, with a
warrant term of two years.

         Section 1.  Definitions

                  1.1 Definitions.  For purposes of this Warrant,  the following
terms shall have the following meanings.

                  "Act" shall mean the Securities Act of 1933, as amended.

                  "Common Stock" means the Company's Common Stock, no par value.

                  "Exercise Price" has the meaning given to that term in Section
2.2.

                  "Merger or Sale" shall have the meaning  given to that term in
Section 7.3.

                  "Shares"  shall  mean the  shares of Common  Stock that can be
acquired upon exercise of the Warrant.

<PAGE>

                  "Termination Date" shall mean the date on which the Warrant is
no longer exercisable, which date shall be February 25, 2002.

                  "Transfer  Agent"  shall  mean  the  Company's  registrar  and
transfer agent, if any, for the Warrant.

                  "Warrant" shall mean this Warrant to purchase shares of Common
Stock.  The term "Warrant" shall include any Warrant  evidenced by a certificate
or  certificates  issued  upon  division,  exchange,  substitution  or  transfer
pursuant to the terms of this Warrant.

         Section 2.  Issuance of Warrant; Form of Warrant.

                  2.1 Issuance. In consideration of the Warrantholder's services
on  behalf  of the  Company,  the  Company  hereby  issues  the  Warrant  to the
Warrantholder to purchase 3,500 shares of Common Stock.

                  2.2  Exercise  Price and  Exercise  Conditions.  The price per
share at which 3,500 shares shall be  purchasable  upon  exercise of the Warrant
(the  "Exercise  Price") is $6.8125  per share  which was the  closing  price of
Cellegy's common stock on February 25, 2000.

                  2.3  Registration.  The Warrant shall be numbered and shall be
registered on the books of the Company.

                  2.4 Transfer.  The Warrant may not be  transferred,  except to
members of the Warrantholder's immediate family or trusts for the benefit of the
Warrantholder or one or more members of the Warrantholder's immediate family. To
the extent that the Warrant is  transferable,  the Warrant shall be transferable
only on the books of the Company maintained at its principal office in South San
Francisco,  California  or, if the  Company  has a Transfer  Agent,  then at the
offices of the  Transfer  Agent,  upon  delivery  thereof  duly  endorsed by the
Warrantholder or by its duly authorized attorney or representative,  accompanied
by proper evidence of succession,  assignment or authority to transfer. Upon any
registration of transfer, the Company shall execute and deliver a new Warrant to
the person entitled thereto.

                  2.5 Certificates. The Warrant may be divided or combined, upon
request to the Company by the Warrantholder,  into a certificate or certificates
representing the right to purchase the same aggregate  number of Shares.  Unless
the context  indicates  otherwise,  the term  "Warrantholder"  shall include any
transferee or transferees of the Warrant.

                  2.6 Signatures. The number of Shares issuable upon exercise of
the Warrant is subject to adjustment upon the occurrence of certain events,  all
as hereinafter provided.  The Warrant shall be executed on behalf of the Company
by its  President or by a Vice  President and attested to by its Secretary or an
Assistant Secretary. A Warrant bearing the signature of an individual who was at
any  time  the  proper   officer  of  the  Company   shall  bind  the   Company,
notwithstanding that such individual shall have ceased to hold such office prior
to the  delivery of such Warrant or did not hold such office on the date of this
Warrant.

                                      -2-
<PAGE>

                  2.7 Legends on Certificate.  Each certificate representing the
Warrant,  and for Shares  initially  issued upon exercise of the Warrant,  shall
bear the following  legends,  unless,  at the time of exercise,  such Shares are
subject to a currently effective Registration Statement under the Act:

                           (a)  THE  SECURITIES   REPRESENTED  BY  THIS  WARRANT
CERTIFICATE  HAVE NOT BEEN  REGISTERED  UNDER  THE  SECURITIES  ACT OF 1933 (THE
"ACT") OR ANY STATE  SECURITIES  LAWS AND MAY NOT BE SOLD,  EXCHANGED,  PLEDGED,
HYPOTHECATED  OR TRANSFERRED  IN ANY MANNER (A "TRANSFER")  EXCEPT IN COMPLIANCE
WITH THE TERMS OF THIS WARRANT, THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS
OR THE COMPANY RECEIVES AN OPINION OF COUNSEL FOR THE HOLDER OF THESE SECURITIES
SATISFACTORY  TO THE  COMPANY,  STATING  THAT SUCH  TRANSFER  IS EXEMPT FROM THE
REGISTRATION AND PROSPECTUS  DELIVERY  REQUIREMENTS OF THE ACT AND COMPLIES WITH
APPLICABLE STATE SECURITIES LAWS.

                           (b)  Any  legend   required   by   applicable   state
securities laws.

                  Any certificate issued at any time in exchange or substitution
for any certificate  bearing such legends (except a new certificate  issued upon
completion of a public distribution  pursuant to a registration  statement under
the Act of the securities represented thereby) shall also bear the above legends
unless,  in the opinion of the Company's  counsel,  the  securities  represented
thereby need no longer be subject to such restrictions.

                  2.8 Exchange of Warrant  Certificate.  Any Warrant certificate
may  be  exchanged  for  another  certificate  or  certificates   entitling  the
Warrantholder  to purchase a like aggregate  number of Shares as the certificate
or certificates  surrendered then entitled such  Warrantholder to purchase.  Any
Warrantholder desiring to exchange a Warrant certificate shall make such request
in writing  delivered to the Company,  and shall surrender,  properly  endorsed,
with  signatures   guaranteed  if  required  by  the  Company,  the  certificate
evidencing the Warrant to be so exchanged.  Thereupon, the Company shall execute
and  deliver to the person  entitled  thereto a new  Warrant  certificate  as so
requested.

         Section 3. Term of Warrant; Exercise of Warrant.

                  3.1  Term.   Subject  to  the  terms  of  this  Warrant,   the
Warrantholder  shall have the right,  at any time after the date of this Warrant
and ending at 5:00 p.m.,  California  Time, on the Termination  Date to purchase
from the  Company  up to the number of fully  paid and  nonassessable  Shares to
which the Warrantholder may at the time be entitled to purchase pursuant to this
Warrant,  upon  surrender  to the  Company,  at  its  principal  office,  of the
certificate  evidencing the Warrant to be exercised,  together with the purchase
form, duly filled in and signed,  with signatures  guaranteed if required by the
Company or its Transfer  Agent,  and upon payment to the Company of the Exercise
Price  for the  number  of  Shares  in  respect  of which  the  Warrant  is then
exercised,  but in no event  for less  than 100  Shares


                                      -3-
<PAGE>

(unless fewer than an aggregate of 100 Shares are then  purchasable  pursuant to
the Warrant).  Notwithstanding the foregoing, the Company shall not be obligated
to  deliver  any  Shares  pursuant  to the  exercise  of the  Warrant,  and  the
Warrantholder  shall  not have the  right to  exercise  the  Warrant,  if in the
Company's  opinion the delivery of Shares upon exercise of the Warrant would not
comply  with any  applicable  federal  or state  securities  laws;  and  without
limiting  the  foregoing,  the Warrant may not be  exercised  by, or  securities
issued  to,  any  Warrantholder  in any state in which  such  exercise  would be
unlawful.

                  3.2  Payment  of  Exercise  Price.  Payment  of the  aggregate
Exercise Price shall be made in cash or by check, or any combination thereof.

                  3.3  Issuance  of  Certificate.  Upon  such  surrender  of the
Warrant and payment of such Exercise Price, the Company shall issue and cause to
be delivered to the Warrantholder and in the Warrantholder's name, a certificate
or certificates  for the number of full Shares so purchased upon the exercise of
the  Warrant,  together  with  cash,  as  provided  herein,  in  respect  of any
fractional  Share otherwise  issuable upon such surrender.  Such  certificate or
certificates shall be deemed to have been issued and any person so designated to
be named  therein  shall be  deemed  to have  become a holder  of record of such
securities  as of the  date of  surrender  of the  Warrant  and  payment  of the
Exercise   Price,  as  aforesaid,   notwithstanding   that  the  certificate  or
certificates   representing   such  securities  shall  not  actually  have  been
delivered.   The  Warrant  shall  be   exercisable,   at  the  election  of  the
Warrantholder,  either in full or from  time to time in part  and,  in the event
that a certificate  evidencing  the Warrant is exercised in respect of less than
all of the Shares specified therein at any time prior to the Termination Date, a
new certificate  evidencing the remaining  portion of the Warrant will be issued
by the Company.

         Section 4.  Payment of Taxes.

         The Company will pay all documentary stamp taxes, if any,  attributable
to the initial issuance of the Warrant or the securities  comprising the Shares;
provided, however, the Company shall not be required to pay any tax which may be
payable in respect of any transfer of the Warrant or the  securities  comprising
the Shares.

         Section 5.  Mutilated or Missing Warrants.

         In case the certificate or certificates evidencing the Warrant shall be
mutilated,  lost, stolen or destroyed,  the Company shall, at the request of the
Warrantholder,  issue and  deliver in  exchange  and  substitution  for and upon
cancellation  of the mutilated  certificate or  certificates,  or in lieu of and
substitution for the certificate or certificates  lost,  stolen or destroyed,  a
new  Warrant  certificate  or  certificates  of like tenor and  representing  an
equivalent right or interest,  but only upon receipt of evidence satisfactory to
the Company of such loss,  theft or  destruction  of such  Warrant and a bond of
indemnity,  if  requested,   also  satisfactory  in  form  and  amount,  at  the
applicant's cost.  Applicants for such substitute Warrant certificate shall also
comply  with such other  reasonable  regulations  and pay such other  reasonable
charges as the Company may prescribe.

                                      -4-
<PAGE>

         Section 6.  Reservation of Shares.

         There  has been  reserved,  and the  Company  shall at all  times  keep
reserved so long as the Warrant remains  outstanding,  out of its authorized and
unissued Common Stock, such number of shares of Common Stock as shall be subject
to purchase under the Warrant.

         Section 7.  Adjustment of Number of Shares.

         The number and kind of securities  purchasable upon the exercise of the
Warrant and the Exercise Price shall be subject to adjustment  from time to time
upon the happening of certain events, as follows:

                  7.1  Adjustments.  The number of Shares  purchasable  upon the
exercise of the Warrant shall be subject to adjustment as follows:

                           (a)  Stock  Splits;  Stock  Dividends.  In  case  the
Company shall (i) pay a dividend in Common Stock, (ii) subdivide its outstanding
Common Stock,  (iii) combine its outstanding  Common Stock into a smaller number
of shares of Common Stock,  including without  limitation any combination of its
outstanding  Common Stock that may occur after October 1, 1997, or (iv) issue by
reclassification  of its Common Stock other securities of the Company,  then the
number of Shares  purchasable  upon  exercise of the Warrant  immediately  prior
thereto shall be adjusted so that the Warrantholder shall be entitled to receive
upon  exercise of the Warrant the kind and number of Shares or other  securities
of the Company  which it would have owned or would have been entitled to receive
immediately  after the happening of any of the events  described  above, had the
Warrant been exercised  immediately  prior to the happening of such event or any
record  date  with  respect  thereto.  Any  adjustment  made  pursuant  to  this
subsection shall become effective  immediately  after the effective date of such
event, retroactive to the record date, if any, for such event.

                           (b) De Minimis  Changes.  No adjustment in the number
of Shares  purchasable  pursuant  to the Warrant  shall be required  unless such
adjustment  would require an increase or decrease of at least one percent in the
number of Shares then purchasable upon the exercise of all Commitment  Warrants;
provided,  however,  that any adjustments which by reason of this subsection are
not  required  to be made  immediately  shall be carried  forward and taken into
account in any subsequent adjustment.

                           (c)  Corresponding   Adjustment  of  Exercise  Price.
Whenever  the number of Shares  purchasable  upon the exercise of the Warrant is
adjusted,  as herein  provided,  the Exercise Price payable upon exercise of the
Warrant shall be adjusted by multiplying such Exercise Price  immediately  prior
to such adjustment by a fraction,  the numerator of which shall be the number of
Shares  purchasable upon the exercise of the Warrant  immediately  prior to such
adjustment,  and the  denominator  of which  shall be the  number  of  Shares so
purchasable immediately thereafter.

                                      -5-
<PAGE>

                           (d)  Notice of  Adjustment.  Whenever  the  number of
Shares  purchasable  upon the  exercise  of the  Warrant is  adjusted  as herein
provided,  the Company  shall cause to be mailed to the  Warrantholder  within a
reasonable time thereafter notice of such adjustment setting forth the number of
Shares  purchasable  upon the exercise of the Warrant after such  adjustment,  a
brief  statement of the facts  requiring such  adjustment and the computation by
which such adjustment was made.

                  7.2  No  Adjustment  for  Dividends.  Except  as  provided  in
subsection  7.1(a),  no adjustment in respect of any dividends or  distributions
out of  earnings  shall  be made  during  the  term of the  Warrant  or upon the
exercise of the Warrant.

                  7.3  Preservation  of Purchase  Rights upon  Reclassification,
Consolidation, etc.

                           (a) Subject to paragraph (b) of this Section, in case
of any  consolidation  of the Company with or merger of the Company into another
corporation where the Company will not be the surviving corporation,  or in case
of any sale or conveyance  to another  corporation  of the  property,  assets or
business of the Company as an entirety or substantially as an entirety (any such
event  referred  to as a "Merger or Sale"),  the  Company or such  successor  or
purchasing  corporation,  as the case may be, shall agree that the Warrantholder
shall have the right  thereafter  upon payment of the  Exercise  Price in effect
immediately prior to such action to purchase,  upon exercise of the Warrant, the
kind and amount of shares and other  securities and property which it would have
owned or have been  entitled to receive  after the  happening  of such Merger or
Sale had the Warrant been exercised  immediately prior to such action.  Any such
agreements  referred to in this subsection shall provide for adjustments,  which
shall be as nearly equivalent as may be practicable to the adjustments  provided
for in this Section.  The provisions of this subsection shall similarly apply to
successive Mergers or Sales.

                           (b) Notwithstanding the foregoing provisions,  if the
surviving,  successor or purchasing corporation does not agree to the provisions
set forth in  paragraph  (a) above,  or if the Board of Directors of the Company
determines that the Warrants should not be outstanding following consummation of
such  Merger  or  Sale,  then  the  Company  shall  deliver  a  notice  to  each
Warrantholder  at least 20 days before the  consummation of such Merger or Sale,
the  Warrantholder  may exercise the Warrant at any time before the consummation
of such  Merger or Sale  (and  such  exercise  may be made  contingent  upon the
consummation  of such Merger or Sale),  and any portion of the Warrant  that has
not been exercised  before  consummation  of such Merger or Sale shall terminate
and expire, and shall no longer be outstanding.

                  7.4 Independent Public  Accountants.  The Company may retain a
firm of independent  public  accountants of recognized  national standing (which
may be any such firm regularly  employed by the Company) to make any computation
required  under this  Section,  and a  certificate  signed by such firm shall be
conclusive  evidence  of the  correctness  of any  computation  made  under this
Section.

                  7.5  Statement on Warrant  Certificates.  Irrespective  of any
adjustments  in the number of securities  issuable upon exercise of the Warrant,
the  Warrant  certificates


                                      -6-
<PAGE>

theretofore  or  thereafter  issued may  continue  to express the same number of
securities as are stated in the similar Warrant  certificate  initially  issued.
However,  the Company  may, at any time in its sole  discretion  (which shall be
conclusive), make any change in the form of Warrant certificate that it may deem
appropriate  and that does not affect the  substance  thereof;  and any  Warrant
certificate  thereafter issued,  whether upon registration of transfer of, or in
exchange or substitution for, an outstanding Warrant certificate,  may be in the
form so changed.

         Section 8. Fractional Interests.

         The Company  shall not be required  to issue  fractional  Shares on the
exercise  of the  Warrant.  If any  fraction  of a Share  would,  except for the
provisions  of this  Section,  be  issuable  on the  exercise of the Warrant (or
specified portion thereof), the Company shall pay an amount in cash equal to the
then fair market value of a share of Common Stock (as  determined  in good faith
by the Board of Directors of the Company) multiplied by such fraction.

         Section 9. No Rights as Shareholder; Notices to Warrantholder.

         Nothing contained in this Warrant shall be construed as conferring upon
the Warrantholder or its transferees any rights as a shareholder of the Company,
including the right to vote, receive dividends,  consent or receive notices as a
shareholder  in  respect of any  meeting of  shareholders  for the  election  of
directors of the Company or any other matter.

         Section 10. Restrictions on Transfer.

         The  Warrantholder  agrees  that  prior to making  any sale,  transfer,
pledge, assignment,  hypothecation, or other disposition (each, a "Transfer") of
the  Warrant or Shares,  the  Warrantholder  shall  give  written  notice to the
Company  describing the manner in which any such proposed Transfer is to be made
and providing such additional  information regarding the Transfer as the Company
reasonably requests. If the Company so requests,  the Warrantholder shall at its
expense  provide the Company with an opinion of counsel  (which  counsel must be
reasonably  satisfactory  to the Company) to the holder,  in form and  substance
satisfactory to the Company, that the proposed Transfer complies with applicable
federal and state  securities  laws.  The Company  shall have no  obligation  to
Transfer  any  Securities  unless  the  holder  thereof  has  complied  with the
foregoing provisions, and any such attempted Transfer shall be null and void.

         Section 11. Certain Representations and Warranties of Warrantholder.

         Warrantholder represents and warrants to, and agrees with, the Company,
that:

                                      -7-
<PAGE>

                  (a) Purchase for Own Account.  This Warrant and the Shares are
being acquired for investment for Warrantholder's own account,  not as a nominee
or  agent,  and not with a view to the  public  resale or  distribution  thereof
within the meaning of the Act, and such  Warrantholder  has no present intention
of selling, granting any participation in, or otherwise distributing the same.

                  (b) Disclosure of Information.  Warrantholder  has received or
has had full access to all the information it considers necessary or appropriate
to  make  an  informed   investment   decision  with  respect  to  the  Warrant.
Warrantholder  has had an opportunity to ask questions and receive  answers from
the Company regarding the terms and conditions of the Warrant and the Shares and
to obtain additional  information  necessary to verify any information furnished
to Warrantholder or to which Warrantholder had access.

                  (c) Investment Experience.  Warrantholder understands that the
receipt of the Warrants and the purchase of the Shares involve substantial risk.
Warrantholder:  (i) has  experience as an investor in securities of companies in
the development stage and acknowledges  that it is able to fend for itself,  can
bear the  economic  risk of such  investment  in the Warrants and Shares and has
such   knowledge  and   experience   in  financial  or  business   matters  that
Warrantholder  is capable of evaluating the merits and risks of this  investment
in the Warrants and Shares and protecting his or her own interests in connection
with  this  investment  and/or  (ii)  has a  preexisting  personal  or  business
relationship  with  the  Company  and  certain  of its  officers,  directors  or
controlling  persons of a nature and duration that enables  Warrantholder  to be
aware of the  character,  business  acumen and financial  circumstances  of such
persons.

                  (d) Restricted Securities.  Warrantholder understands that the
Warrants and the Shares are  characterized as "restricted  securities" under the
Act inasmuch as they are being  acquired from the Company in a  transaction  not
involving a public  offering and that under the Act and  applicable  regulations
thereunder such securities may be resold without registration under the Act only
in certain limited circumstances.  In this connection,  Warrantholder represents
that  Warrantholder  is familiar  with Rule 144 of the  Securities  and Exchange
Commission,  as  presently in effect,  and  understands  the resale  limitations
imposed thereby and by the Securities Act.  Warrantholder  understands  that the
Company is under no obligation to register any of the securities  sold hereunder
except as provided in Section 12 below.

                  (e) Further  Limitations  on  Disposition.  Without in any way
limiting the representations set forth above,  Warrantholder  further agrees not
to make any  disposition  of the  Warrant  or all or any  portion  of the Shares
unless and until:

                           (i) there is then in effect a registration  statement
under the Act covering such proposed disposition and such disposition is made in
accordance with such registration statement; or

                           (ii)  (A)  Warrantholder   shall  have  notified  the
Company of the proposed  disposition and shall have furnished the Company with a
statement of the circumstances  surrounding the proposed  disposition,  and (ii)
Warrantholder  shall have furnished the Company, at the expense of Warrantholder
or its transferee,  with an opinion of


                                      -8-
<PAGE>

counsel,  reasonably satisfactory to the Company, that such disposition will not
require registration of such securities under the Act.

Notwithstanding  the  provisions  of  paragraphs  (i) and  (ii)  above,  no such
registration  statement  or opinion of counsel  shall be  required:  (1) for any
transfer of any Shares in  compliance  with SEC Rule 144 or (2) for the transfer
by gift, will or intestate  succession by  Warrantholder to his or her spouse or
lineal descendants or ancestors or any trust for any of the foregoing;  provided
that in each of the  foregoing  cases the  transferee  agrees in  writing  to be
subject to the terms of this Section 11 to the same extent as if the  transferee
were the original Warrantholder.

                  (f) Legends. It is understood that the certificates evidencing
the Warrant Shares will bear the legends set forth below:

                           (i)  THE  SECURITIES   REPRESENTED  BY  THIS  WARRANT
CERTIFICATE  HAVE NOT BEEN  REGISTERED  UNDER  THE  SECURITIES  ACT OF 1933 (THE
"ACT") OR ANY STATE  SECURITIES  LAWS AND MAY NOT BE SOLD,  EXCHANGED,  PLEDGED,
HYPOTHECATED  OR TRANSFERRED  IN ANY MANNER (A "TRANSFER")  EXCEPT IN COMPLIANCE
WITH THE TERMS OF THIS WARRANT, THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS
OR THE COMPANY RECEIVES AN OPINION OF COUNSEL FOR THE HOLDER OF THESE SECURITIES
SATISFACTORY  TO THE  COMPANY,  STATING  THAT SUCH  TRANSFER  IS EXEMPT FROM THE
REGISTRATION AND PROSPECTUS  DELIVERY  REQUIREMENTS OF THE ACT AND COMPLIES WITH
APPLICABLE STATE SECURITIES LAWS.

                           (ii) Any legend  required by the laws of the State of
California:

The legend  set forth in (i) above  shall be  removed  by the  Company  from any
certificate  evidencing  Shares  upon  delivery  to the Company of an opinion by
counsel,  reasonably  satisfactory to the Company, that a registration statement
under the Act is at that time in effect with respect to the legended security or
that such  security  can be freely  transferred  in a public sale without such a
registration  statement  being  in  effect  and  that  such  transfer  will  not
jeopardize the exemption or exemptions from  registration  pursuant to which the
Company issued the Shares.

         Section 12. Registration Rights.

         The  Company  will  use  all  reasonable  efforts  to  register,  on  a
registration  statement that the Company intends to file during 2000, either the
issuance of shares of Common Stock  issuable upon exercise of the Warrant or the
resale of such shares.  The  Warrantholder  agrees to cooperate with the Company
and provide such  information as the Company  reasonably  requests in connection
with such registration.

         Section 13. Miscellaneous.

                                      -9-
<PAGE>

                  13.1  Notices.  Any  notice  pursuant  to this  Warrant by the
Company or by a  Warrantholder  or a holder of Shares  shall be in  writing  and
shall be  deemed to have been duly  given if  delivered  or mailed by  certified
mail, return receipt requested:

                  (a) If to a Warrantholder or a holder of Shares,  addressed to
the  holder's  address  on the books of the  Company or the  Company's  transfer
agent; and

                  (b)  If to  the  Company  addressed  to it  at  the  Company's
principal executive offices, Attention: President.

         Each party may from time to time change the address to which notices to
it are to be delivered or mailed  hereunder by notice in accordance  herewith to
the other party.

                  13.2  Successors.  All the  covenants  and  provisions of this
Warrant by or for the benefit of the Company, the Warrantholder,  or the holders
of Shares,  shall bind and inure to the benefit of their  respective  successors
and assigns hereunder.

                  13.3 Applicable  Law;  Consent to  Jurisdiction.  This Warrant
shall be governed by and construed in  accordance  with the laws of the State of
California,  without  giving  effect to the  choice of law or  conflict  of laws
principles thereof.  Warrantholder and the Company each consent to the exclusive
jurisdiction  and venue of the federal and state court in the  district in which
the Company's  principal  executive offices are then-located for purposes of any
action  arising out of or relating to this  Warrant,  and agrees that service of
process in any such action may be effected by means of the  procedures set forth
in Section 13.1 above for giving notices under this Warrant.

                  13.4 Benefits of this  Warrant.  Nothing in this Warrant shall
be construed to give to any person or  corporation  other than the Company,  the
Warrantholder and the holders of Shares, any legal or equitable right, remedy or
claim under this  Warrant,  and this Warrant shall be for the sole and exclusive
benefit of the Company, the Warrantholder and the holders of Shares.

                  13.5  Amendment.  Neither this Warrant nor any term hereof may
be amended, waived,  discharged or terminated other than by a written instrument
signed by the party  against whom  enforcement  of any such  amendment,  waiver,
discharge or termination is sought.

                  13.6 Entire Agreement.  This Warrant  constitutes the full and
entire  understanding  and  agreement  between  the  parties  with regard to the
subject matter hereof, and no party shall be liable or bound to any other in any
manner by any representations,  warranties,  covenants, and agreements except as
specifically set forth herein and therein. Nothing in this Warrant, expressed or
implied,  is intended to confer upon any party,  other than the parties  hereto,
and their respective successors and assigns, any rights, remedies,  obligations,
or liabilities under or by reason of this Warrant,  except as expressly provided
herein.

                  13.7 Separability.  Any invalidity,  illegality, or limitation
of the  enforceability  with  respect  to any  party  of any  one or more of the
provisions of this Warrant,


                                      -10-
<PAGE>

or any part  thereof,  whether  arising by reason of the law of any such party's
domicile or otherwise, shall in no way affect or impair the validity,  legality,
or enforceability of this Warrant with respect to all other parties. In case any
provision of this  Warrant  shall be invalid,  illegal,  or  unenforceable,  the
validity,  legality, and enforceability of the remaining provisions shall not in
any way be affected or impaired thereby.

                  13.8 Counterparts.  This Warrant may be executed in any number
of counterparts,  each of which shall be an original,  but all of which together
shall constitute one instrument.

                  [Remainder of this page intentionally left blank]


                                      -11-
<PAGE>



         IN WITNESS  WHEREOF,  the Company  has caused  this  Warrant to be duly
executed, all as of the day and year first above written.

                               CELLEGY PHARMACEUTICALS, INC.



                               By: /s/ A. Richard Juelis
                                  ----------------------------------------
                                           A. Richard Juelis
                                           Chief Financial Officer



                               Attest:



                               ------------------------------




                                      -12-
<PAGE>

                          CELLEGY PHARMACEUTICALS, INC.

                                  PURCHASE FORM

Cellegy Pharmaceuticals, Inc.
349 Oyster Point Blvd., Suite 200
South San Francisco, CA  94080

         The  undersigned  hereby  irrevocably  elects to exercise  the right of
purchase  represented  by the within  Warrant  Certificate  for, and to purchase
thereunder,  __________  share of  Common  Stock  (the  "Shares")  provided  for
therein, and requests that certificates for the Shares be issued in the name of:

                     --------------------------------------
         (Please Print or Type Name, Address and Social Security Number)
                     --------------------------------------
                     --------------------------------------

and, if said number of Shares shall not be all the Shares purchasable hereunder,
that a new Warrant  Certificate for the balance of the Shares  purchasable under
the within  Warrant  Certificate  be registered  in the name of the  undersigned
Warrantholder or the undersigned's  assignee as below indicated and delivered to
the address stated below.

Dated: _________________________________


Name of Warrantholder
or Assignee:____________________________
                  (Please Print)

Address:________________________________

        ________________________________

Signature:______________________________

Note: The above signature must correspond with the name as written upon the face
of  this  Warrant  Certificate  in  every  particular,   without  alteration  or
enlargement or any change whatever, unless these Warrants have been assigned.

Signature Guaranteed:___________________

(Signature  must be guaranteed  by a bank or trust  company  having an office or
correspondence  in  the  United  States  or by a  member  firm  of a  registered
securities exchange or the National Association of Securities Dealers, Inc.)

<PAGE>


                                   ASSIGNMENT

                 (To be signed only upon assignment of Warrants)



    FOR VALUE RECEIVED, the undersigned hereby sells, assigns and transfers unto

Name and Address of Assignee Must Be Printed or Typewritten

                     --------------------------------------
                     --------------------------------------
                     --------------------------------------


the  within   Warrants,   hereby   irrevocably   constituting   and   appointing
___________________,  Attorney  to  transfer  said  Warrants on the books of the
Company, with full power of substitution in the premises.

Dated:
       -------------------------------------------------------------------------
                         Signature of Registered Holder

Note:  The  signature on this  assignment  must  correspond  with the name as it
appears upon the face of the within  Warrant  Certificate  in every  particular,
without alteration or enlargement or any change whatever.

Signature Guaranteed:______________________


(Signature  must be guaranteed  by a bank or trust  company  having an office or
correspondence  in  the  United  States  or by a  member  firm  of a  registered
securities exchange or the National Association of Securities Dealers, Inc.)


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