CELLEGY PHARMACEUTICALS INC
S-3/A, EX-5.01, 2001-01-05
PHARMACEUTICAL PREPARATIONS
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                                                                   EXHIBIT 5.01



                                 January 4, 2001



Cellegy Pharmaceuticals, Inc.
349 Oyster Point Boulevard, Suite 200
South San Francisco, CA 94080

Gentlemen/Ladies:

         At your request,  we have examined the  Registration  Statement on Form
S-3 (the  "Registration  Statement") filed by Cellegy  Pharmaceuticals,  Inc., a
California  corporation  (the  "Company"),  with  the  Securities  and  Exchange
Commission  (the  "Commission")  on or about November 7, 2000 in connection with
the registration under the Securities Act of 1933, as amended,  of the resale of
up to an  aggregate  of  2,143,870  shares of the  Company's  Common  Stock (the
"Stock"),  including  1,669,224 shares that are presently issued and outstanding
(the  "Outstanding  Shares") and 474,646 shares (the "Warrant  Shares") that are
issuable upon the exercise of certain  warrants (the "Warrants") held by certain
of  the  Selling   Shareholders  (the  "Selling   Shareholders")  named  in  the
Registration Statement.

         In rendering this opinion, we have examined the following documents:

          (1)     a copy of the  Company's  Amended  and  Restated  Articles  of
                  Incorporation filed with the California  Secretary of State on
                  August 16, 1995, the Certificate of  Determination of Series A
                  Preferred  Stock filed with the California  Secretary of State
                  on April 15,  1996,  and the  Certificate  of Amendment to the
                  Certificate of Determination of Series A Preferred Stock filed
                  with the  California  Secretary  of State  on April  17,  1996
                  (together,   the  "Restated   Articles"),   certified  by  the
                  Company's Secretary on October 2, 2000;

          (2)     a copy of the  Company's  Bylaws,  certified by the  Company's
                  Secretary on October 2, 2000;

          (3)     the Registration  Statement (including the Prospectus included
                  therein), together with the Exhibits filed as a part thereof;

          (4)     Common Stock Purchase Agreement dated October 2, 2000, between
                  the Company and SMALLCAP World Fund,  Framlington Health Fund,
                  Munder Framlington Healthcare Fund, and Four Partners;


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January 4, 2001
Page 2


          (5)     Common Stock Purchase  Agreement  dated April 14, 2000 between
                  the Company and Quay  Pharmaceuticals  Pty Ltd,  Richcone  Pty
                  Ltd, and Cellegy  Australia Pty Ltd (The  purchase  agreements
                  referred  to in  clauses  (4)  through  (5)  are  collectively
                  referred to in this letter as the "Purchase Agreements.");

          (6)     two  Common  Stock  Purchase  Warrants  dated  March 21,  2000
                  between the Company and Gruntal & Co., L.L.C.;

          (7)     Common Stock Purchase  Warrant dated June 13, 2000 between the
                  Company and Richcone Pty Ltd;

          (8)     Common Stock Purchase  Warrant dated February 25, 2000 between
                  the Company and Marc Parham,  Ph.D.  (The  warrant  agreements
                  referred to in clauses (6) through (8) above are  collectively
                  referred to in this letter as the "Warrant Agreements.");

         (10)     copies of the  minutes  of  meetings  and  actions  by written
                  consent of the Company's Board of Directors that are contained
                  in the Company's  minute books that have been  furnished to us
                  by the  Company  in  connection  with  the  rendering  of this
                  opinion (the "Minute Book Contents"); and

         (11)     the  stock  records  that  the  Company  has  provided  to  us
                  (consisting of a certificate from the Company's transfer agent
                  verifying the number of the Company's  issued and  outstanding
                  shares of  capital  stock as of the date  hereof and a list of
                  option and warrant  holders  respecting the Company's  capital
                  and of any rights to purchase  capital stock that was prepared
                  by the Company and dated November 2, 2000 verifying the number
                  of such issued and outstanding securities).

         (12)     a  Management  Certificate  addressed  to us and dated of even
                  date  herewith   executed  by  the  Company  (the  "Management
                  Certificate")    containing    certain   factual   and   other
                  representations.

         In our  examination of documents for purposes of this opinion,  we have
assumed,  and express no opinion as to, the  genuineness  of all  signatures  on
original documents, the authenticity and completeness of all documents submitted
to us as  originals,  the  conformity  to  originals  and  completeness  of  all
documents  submitted to us as copies,  the legal  competence  or capacity of all
persons or entities executing the same, the lack of any undisclosed termination,
modification,  waiver or amendment  to any  document  reviewed by us and the due
authorization,  execution and delivery of all documents where due authorization,
execution and delivery are prerequisites to the effectiveness  thereof.  We have
also assumed that the certificates  representing the Stock have been, or will be
when  issued,  properly  signed by  authorized  officers of the Company or their
agents.

         As to matters of fact relevant to this  opinion,  we have relied solely
upon our  examination  of the  documents  referred to above and have assumed the
current accuracy and completeness of the information obtained from the documents
referred   to  above,   and  the   representations   and



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January 4, 2001
Page 3


warranties  made by  representatives  of the  Company to us,  including  without
limitation,  those  set  forth in the  Management  Certificate.  We have made no
independent investigation or other attempt to verify the accuracy of any of such
information or to determine the existence or  non-existence of any other factual
matters;  however,  we are not aware of any facts that would cause us to believe
that the opinion expressed herein is not accurate.

         We are  admitted to  practice  law in the State of  California,  and we
render  this  opinion  only with  respect  to, and  express  no  opinion  herein
concerning the application or effect of the laws of any jurisdiction other than,
the existing  federal laws of the United States of America and the existing laws
of the State of California.

         In connection with our opinion  expressed  below, we have assumed that,
at or  before  the time of any  resale of  shares  of  Stock,  the  Registration
Statement will have been declared effective under the Securities Act of 1933, as
amended,  that the registration will apply to such resale of shares of Stock and
will not have been  modified or rescinded  and that there will not have occurred
any change in law  affecting  the validity or  enforceability  of such shares of
Stock.

         The Company has  informed us that the Selling  Shareholders  may resell
the stock on a delayed or continuous basis. This opinion is limited to the laws,
including  the rules and  regulations,  as in effect on the date hereof.  We are
basing  this  opinion  on  our   understanding   that,   prior  to  any  Selling
Shareholder's  resale of Stock,  the  Company  will  advise us in writing of the
terms  thereof  and other  information  material  thereto  and will afford us an
opportunity to review the operative documents pursuant to which such Stock is to
be resold (including the Registration  Statement,  the Prospectus and applicable
Prospectus  Summary,  as then in  effect)  and  will  file  such  supplement  or
amendment to this opinion,  if any as we may  reasonably  consider  necessary or
appropriate with respect to such resale. However, we undertake no responsibility
to  monitor  the  Company's  or Selling  Shareholders'  future  compliance  with
applicable  laws,  rules or regulations of the Commission or other  governmental
body. We also assume the Company will timely file any and all supplements to the
Registration Statement and Prospectus as are necessary to comply with applicable
laws in effect from time to time.

         In  rendering  any  opinion  that the shares of Stock are, or will when
issued be, "fully paid," we have assumed that such shares were or will be issued
in  accordance  with  the  terms  of the  Purchase  Agreements  or  the  Warrant
Agreements,  and  that the  Company  has  received  full  consideration  for the
issuance of such  shares  provided  for in the  Purchase  Agreements  or Warrant
Agreements (as the case may be), and we have relied solely,  without independent
investigation,  upon the  representation  of the  Company to that  effect in the
Management Certificate referred to above.

         Based upon the foregoing, it is our opinion that the Outstanding Shares
to be sold by the Selling  Shareholders  pursuant to the Registration  Statement
are validly issued,  fully paid and nonassessable,  and that the Warrant Shares,
when and if issued upon  exercise of the Warrants and fully paid for as provided
in the  Warrants  and Warrant  Agreements,  will be  (assuming no change in such
documents or applicable law), validly issued, fully paid and nonassessable.


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January 4, 2001
Page 4

         We consent to the use of this opinion as an exhibit to the Registration
Statement  and  further  consent  to  all  references  to  us,  if  any,  in the
Registration  Statement,  the  Prospectus  constituting  a part  thereof and any
amendments  thereto.  This  opinion  speaks only as of its date and we assume no
obligation  to update this opinion  should  circumstances  change after the date
hereof.  This opinion is intended solely for use in connection with issuance and
sale of shares  subject to the  Registration  Statement  and is not to be relied
upon for any other purpose.

                                Very truly yours,

                                FENWICK & WEST LLP


                                By:  C. Kevin Kelso, a Partner



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