AASTROM BIOSCIENCES INC
SC 13G, 2000-03-09
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13G

             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
           TO RULE 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED
                           PURSUANT TO RULE 13d-2(b)
                                (Amendment No. )*

                            AASTROM BIOSCIENCES, INC.
                             -----------------------
                                (Name of Issuer)

                           Common Stock, no par value
                          -----------------------------
                         (Title of Class of Securities)

                                    00253U107
                               -------------------
                                 (CUSIP Number)

                        RGC International Investors, LDC
                     c/o Rose Glen Capital Management, L.P.
                     251 St. Asaphs Rd., 3 Bala Plaza - East
                              Bala Cynwyd, PA 19004
                             Attn: Gary S. Kaminsky
                                 (610) 617-5900
                 -----------------------------------------------
           (Name, Address and Telephone Number of Person Authorized to
                       Receive Notices and Communications)

                                February 29, 2000
              -----------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

                / /  Rule 13d-1(b)
                /X/  Rule 13d-1(c)
                / /  Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 or otherwise subject to the liabilities of that section of the Act but
shall be subject to all other provisions of the Act.


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CUSIP NUMBER: 00253U107                                        PAGE 2 OF 9 PAGES

- --------------------------------------------------------------------------------
1)              Names of Reporting Persons; S.S. or I.R.S. Identification

                RGC International Investors, LDC
- --------------------------------------------------------------------------------
2)              Check the Appropriate Box if a Member of a Group
                (See Instructions)

                (a)  /X/
                (b)  N/A
- --------------------------------------------------------------------------------

3)              SEC Use Only

- --------------------------------------------------------------------------------

4)              Citizenship or Place of Organization              Cayman Islands

- --------------------------------------------------------------------------------
                      5)      Sole Voting Power

   Number of          ----------------------------------------------------------
    Shares
  Beneficially        6)     Shared Voting Power                    3,114,151(1)
   Owned by
Each Reporting        ----------------------------------------------------------
 Person With
                      7)      Sole Dispositive Power

                      ----------------------------------------------------------
                      8)      Shared Dispositive Power              3,114,151(1)

- --------------------------------------------------------------------------------
9)              Aggregate Amount Beneficially
                Owned by Each Reporting Person                      3,114,151(1)
- --------------------------------------------------------------------------------
10)             Check if the Aggregate Amount in Row (9)
                Excludes Certain Shares (See Instructions)                   N/A
- --------------------------------------------------------------------------------

11)             Percent of Class Represented by Amount in Row (9)           9.9%

- --------------------------------------------------------------------------------

12)             Type of Reporting Person  (See Instructions)                  00

- --------------------------------------------------------------------------------


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CUSIP NUMBER: 00253U107                                        PAGE 3 OF 9 PAGES
- --------------------------------------------------------------------------------
1)              Names of Reporting Persons; S.S. or I.R.S. Identification

                Rose Glen Capital Management, L.P.
- --------------------------------------------------------------------------------
2)             Check the Appropriate Box if a Member of a Group (See
               Instructions)

                (a)  /X/
                (b)  N/A
- --------------------------------------------------------------------------------

3)             SEC Use Only

- --------------------------------------------------------------------------------

4)              Citizenship or Place of Organization                    Delaware

- --------------------------------------------------------------------------------

                      5)      Sole Voting Power

  Number of           ----------------------------------------------------------
   Shares
 Beneficially         6)      Shared Voting Power                   3,114,151(1)
  Owned by
Each Reporting        ----------------------------------------------------------
 Person With
                      7)      Sole Dispositive Power

                      ----------------------------------------------------------
                      8)      Shared Dispositive Power              3,114,151(1)

- --------------------------------------------------------------------------------
9)              Aggregate Amount Beneficially                       3,114,151(1)
                Owned by Each Reporting Person
- --------------------------------------------------------------------------------
10)             Check if the Aggregate Amount in Row (9)
                Excludes Certain Shares (See Instructions)                   N/A
- --------------------------------------------------------------------------------

11)             Percent of Class Represented by Amount in Row (9)      9.9%

- --------------------------------------------------------------------------------

12)             Type of Reporting Persons (See Instructions)             PN
- --------------------------------------------------------------------------------


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CUSIP NUMBER: 00253U107                                        PAGE 4 OF 9 PAGES
- --------------------------------------------------------------------------------
1)           Names of Reporting Persons; S.S. or I.R.S. Identification

             RGC General Partner Corp.
- --------------------------------------------------------------------------------
2)             Check the Appropriate Box if a Member of a Group (See
               Instructions)

                (a)  /X/
                (b)  N/A
- --------------------------------------------------------------------------------

3)              SEC Use Only

- --------------------------------------------------------------------------------

4)              Citizenship or Place of Organization                    Delaware
- --------------------------------------------------------------------------------

   Number of            5)      Sole Voting Power
    Shares              --------------------------------------------------------
 Beneficially
   Owned by             6)      Shared Voting Power                 3,114,151(1)
Each Reporting          --------------------------------------------------------
 Person With
                        7)       Sole Dispositive Power

                        --------------------------------------------------------

                        8)       Shared Dispositive Power           3,114,151(1)

- --------------------------------------------------------------------------------
9)              Aggregate Amount Beneficially                       3,114,151(1)
                Owned by Each Reporting Person
- --------------------------------------------------------------------------------
10)             Check if the Aggregate Amount in Row (9)
                Excludes Certain Shares (See Instructions)                   N/A
- --------------------------------------------------------------------------------

11)             Percent of Class Represented by Amount in Row (9)           9.9%
- --------------------------------------------------------------------------------

12)             Type of Reporting Persons (See Instructions)                  CO
- --------------------------------------------------------------------------------


<PAGE>


CUSIP NUMBER: 00253U107                                        PAGE 5 OF 9 PAGES



                     FOOTNOTES TO COVER PAGE OF SCHEDULE 13G

1. This Schedule 13G is being filed on behalf of the following persons (the
"Filers"):

        (1)     RGC International Investors, LDC, a Cayman Islands limited
                duration company ("RGC");

        (2)     Rose Glen Capital Management, L.P., a Delaware limited
                partnership ("Rose Glen"); and

        (3)     RGC General Partner Corp., a Delaware corporation ("Partner").

        Each of Rose Glen and Partner shall be collectively referred to as the
        "RGC Affiliates."

        RGC is a private investment fund. Rose Glen is the investment manager of
        RGC and Partner is the general partner of Rose Glen. The Common Stock to
        which this Schedule 13G relates is owned by RGC. The name, residence or
        business address, principal occupation or employment and citizenship of
        each of the executive officers of the RGC Affiliates are set forth in
        the table on Schedule A hereto.

        RGC owns, and Rose Glen as investment manager of RGC and Partner as
        general partner of Rose Glen beneficially own, 3,114,151 shares of
        Common Stock or approximately 9.9% of the outstanding shares of the
        Issuer. The total number of shares of Common Stock beneficially owned by
        the Filers consists of (i) 2,264,151 shares of Common Stock and (ii)
        850,000 shares of Common Stock that are currently issuable within 60
        days of February 29, 2000 upon exercise of a Warrant to purchase an
        aggregate of 1,132,075 shares of Common Stock. The Warrant is
        exercisable at any time at an exercise price of $3.695 and expires on
        March 1, 2003. The Warrant is exercisable only to the extent that the
        number of shares of Common Stock issuable upon exercise of the Warrant
        together with any other shares of Common Stock beneficially owned by the
        Filers would not exceed 9.9% of the then outstanding Common Stock of the
        Issuer.

       Each of RGC and the RGC Affiliates has sole power to vote and dispose of
       the shares indicated.


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CUSIP NUMBER: 00253U107                                        PAGE 6 OF 9 PAGES
                                  SCHEDULE 13G

ITEM 1.   (a).  NAME OF ISSUER: Aastrom Biosciences, Inc.(the"Issuer")

          (b).  ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:
                24 Frank Lloyd Wright Drive, P.O. Box 376, Ann Arbor, MI 48106

ITEM 2.   (a).  NAME OF PERSON FILING: This Schedule 13G is being filed on
                behalf of the following persons (the "Filers"):

               (1)  RGC International Investors, LDC, a Cayman Islands limited
                    duration company ("RGC");

               (2)  Rose Glen Capital Management, L.P., a Delaware limited
                    partnership ("Rose Glen"); and

               (3)  RGC General Partner Corp., a Delaware corporation
                    ("Partner").

          Each of Rose Glen and Partner shall be collectively referred to as the
          "RGC Affiliates."

          RGC is a private investment fund. Rose Glen is the investment manager
          of RGC and Partner is the general partner of Rose Glen. The Common
          Stock to which this Schedule 13G relates is owned by RGC. The name,
          residence or business address, principal occupation or employment and
          citizenship of each of the executive officers of the RGC Affiliates
          are set forth in the table on Schedule A hereto.

          (b). ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE: The
               business address for each of the RGC Affiliates is 251 St. Asaphs
               Road, Suite 200, 3 Bala Plaza - East, Bala Cynwyd, Pennsylvania
               19004. The business address for RGC is c/o SEI Investments -
               Global Fund Sevices Limited., 30 Herbert Street, Dublin, Ireland
               2. The residence or business address of each of the executive
               officers of the RGC Affiliates are set forth in the table on
               Schedule A hereto.

          (c). CITIZENSHIP: RGC is a Cayman Islands limited duration company.
               Rose Glen is a Delaware limited partnership. Partner is a
               Delaware corporation. The citizenship of each of the executive
               officers of the RGC Affiliates are set forth in the table on
               Schedule A hereto.

          (d). TITLE OF CLASS OF SECURITIES: Common Stock, no par value (the
               "Common Stock").

          (e). CUSIP NUMBER: 00253U107


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NUMBER: 00253U107                                              PAGE 7 OF 9 PAGES

ITEM 3.  IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b), OR 13d-2(b) OR
         (c), CHECK WHETHER THE PERSON FILING IS A: N/A

         If this statement is filed pursuant to Rule 13d-1(c), check this box.
         /X/

ITEM 4.  OWNERSHIP. For information concerning the ownership of Common Stock of
         the Issuer by RGC and the RGC Affiliates, see Items 5 through 9 and 11
         of the cover pages to this Schedule 13G and the footnotes thereto.


ITEM 5.  OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS. N/A

ITEM 6.  OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON. RGC
         has granted to Rose Glen, as investment manager, the sole power to
         manage RGC's investments.

ITEM 7.  IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
         SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY. N/A

ITEM 8.  IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP. N/A

ITEM 9.  NOTICE OF DISSOLUTION OF GROUP. N/A

ITEM 10. CERTIFICATIONS.

          By signing below I certify that, to the best of my knowledge and
          belief, the securities referred to above were not acquired and are not
          held for the purpose of or with the effect of changing or influencing
          the control of the issuer of the securities and were not acquired and
          are not held in connection with or as a participant in any transaction
          having that purpose or effect.


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NUMBER: 00253U107                                              PAGE 8 OF 9 PAGES


                                   SIGNATURES

                After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.

DATED:  March 9, 2000.

                RGC INTERNATIONAL INVESTORS, LDC
                By: Rose Glen Capital Management, L.P.
                By: RGC General Partner Corp.

                By:    /s/ Wayne D. Bloch
                    -------------------------
                    Wayne D. Bloch
                    Managing Director

                ROSE GLEN CAPITAL MANAGEMENT, L.P.
                By: RGC General Partner Corp.

                By:    /s/ Wayne D. Bloch
                    ------------------------
                    Wayne D. Bloch
                    Managing Director

                RGC GENERAL PARTNER CORP.

                By:    /s/ Wayne D. Bloch
                    ------------------------
                    Wayne D. Bloch
                    Managing Director

            ATTENTION: INTENTIONAL MISSTATEMENTS OR OMISSIONS OF FACT
       CONSTITUTE FEDERAL CRIMINAL VIOLATIONS (SEE 18 U.S.C. SECTION 1001)


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CUSIP NUMBER: 00253U107                                        PAGE 9 OF 9 PAGES


                                   SCHEDULE A

                The name, citizenship and principal occupation or employment of
each executive officer of the RGC Affiliates are set forth below. The business
address of the above listed persons is 251 St. Asaphs Road, Suite 200, 3 Bala
Plaza-East, Bala Cynwyd, Pennsylvania 19004.

<TABLE>
<CAPTION>
Name and Position     Citizenship     Principal Occupation or Employment
- -----------------     -----------     -----------------------------------
<S>                  <C>             <C>
Wayne D. Bloch        United States   Managing Director - RGC General Partner Corp.*
Gary S. Kaminsky      United States   Managing Director - RGC General Partner Corp.*
Steven B. Katznelson  Canada          Managing Director - RGC General Partner Corp.*
</TABLE>

RGC is governed by a board of directors consisting of Messrs. Bloch, Kaminsky
and Katznelson and three additional persons who are affiliates of RGC's
administrator, SEI Investments Global Fund Services Limited. RGC's board of
directors has granted to Rose Glen, as investment manager, the sole power to
manage RGC's portfolio of investments.

*    Messrs. Bloch, Kaminsky and Katznelson own all of the outstanding capital
     stock of Partner, are the sole officers and directors of Partner and are
     parties to a shareholders agreement pursuant to which they collectively
     control Partner. Through Partner, Messrs. Bloch, Kaminsky and Katznelson
     control Rose Glen.


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