SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
________________________
SCHEDULE 13G/A
Information Statement Pursuant to Rules 13d-1 and 13d-2
Under the Securities Exchange Act of 1934
(Amendment No. 1)
Trega Biosciences, Inc.
_________________________________________________________________
(Name of Issuer)
Common Stock, $.001 par value
_________________________________________________________________
(Title of Class of Securities)
0008946991
_________________________________________________________________
(CUSIP Number)
________________________
<PAGE>
CUSIP No. 0008946991 Page 2 of 7 Pages
_________________________________________________________________
1) Name of Reporting Person Domain Partners
S.S. or I.R.S. Identification II, L.P.
No. of Above Person
_________________________________________________________________
2) Check the Appropriate Box (a) [ X ]
if a Member of a Group (b) [ ]
_________________________________________________________________
3) SEC Use Only
_________________________________________________________________
4) Citizenship or Place Delaware
of Organization
_________________________________________________________________
Number of 5) Sole Voting 1,444,084 shares of
Shares Beneficially Power Common Stock, $.001
Owned by Each par value ("Common
Reporting Person Stock")
________________________________________
6) Shared Voting
Power -0-
________________________________________
7) Sole Disposi- 1,444,084 shares of
tive Power Common Stock
________________________________________
8) Shared Dis-
positive Power -0-
________________________________________
9) Aggregate Amount Beneficially 1,444,084 shares of
Owned by Each Reporting person Common Stock
_________________________________________________________________
10) Check if the Aggregate
Amount in Row (9)
Excludes Certain Shares
_________________________________________________________________
11) Percent of Class
Represented by 10.4%
Amount in Row (9)
_________________________________________________________________
12) Type of Reporting
Person PN
<PAGE>
CUSIP No. 0008946991 Page 3 of 7 Pages
_________________________________________________________________
1) Name of Reporting Person Domain Partners
S.S. or I.R.S. Identification III, L.P.
No. of Above Person
_________________________________________________________________
2) Check the Appropriate Box (a) [ X ]
if a Member of a Group (b) [ ]
_________________________________________________________________
3) SEC Use Only
_________________________________________________________________
4) Citizenship or Place Delaware
of Organization
_________________________________________________________________
Number of 5) Sole Voting 1,086,633 shares of
Shares Beneficially Power Common Stock
Owned by Each
Reporting Person
________________________________________
6) Shared Voting
Power -0-
________________________________________
7) Sole Disposi- 1,086,633 shares of
tive Power Common Stock
________________________________________
8) Shared Dis-
positive Power -0-
________________________________________
9) Aggregate Amount Beneficially 1,086,633 shares of
Owned by Each Reporting person Common Stock
_________________________________________________________________
10) Check if the Aggregate
Amount in Row (9)
Excludes Certain Shares
_________________________________________________________________
11) Percent of Class
Represented by 7.9%
Amount in Row (9)
_________________________________________________________________
12) Type of Reporting
Person PN
<PAGE>
CUSIP No. 0008946991 Page 4 of 7 Pages
_________________________________________________________________
1) Name of Reporting Person DP III Associates,
S.S. or I.R.S. Identification L.P.
No. of Above Person
_________________________________________________________________
2) Check the Appropriate Box (a) [ X ]
if a Member of a Group (b) [ ]
_________________________________________________________________
3) SEC Use Only
_________________________________________________________________
4) Citizenship or Place Delaware
of Organization
_________________________________________________________________
Number of 5) Sole Voting 37,793 shares of
Shares Beneficially Power Common Stock
Owned by Each
Reporting Person
________________________________________
6) Shared Voting
Power -0-
________________________________________
7) Sole Disposi- 37,793 shares of
tive Power Common Stock
________________________________________
8) Shared Dis-
positive Power -0-
________________________________________
9) Aggregate Amount Beneficially 37,793 shares of
Owned by Each Reporting person Common Stock
_________________________________________________________________
10) Check if the Aggregate
Amount in Row (9)
Excludes Certain Shares
_________________________________________________________________
11) Percent of Class
Represented by 0.3%
Amount in Row (9)
_________________________________________________________________
12) Type of Reporting
Person PN
<PAGE>
CUSIP No. 0008946991 Page 5 of 7 Pages
_________________________________________________________________
1) Name of Reporting Person Domain Associates
S.S. or I.R.S. Identification
No. of Above Person
_________________________________________________________________
2) Check the Appropriate Box (a) [ X ]
if a Member of a Group (b) [ ]
_________________________________________________________________
3) SEC Use Only
_________________________________________________________________
4) Citizenship or Place New Jersey
of Organization
_________________________________________________________________
Number of 5) Sole Voting 6,966 shares of Shares
Beneficially Power Common Stock
Owned by Each
Reporting Person
________________________________________
6) Shared Voting
Power -0-
________________________________________
7) Sole Disposi- 6,966 shares of
tive Power Common Stock
________________________________________
8) Shared Dis-
positive Power -0-
________________________________________
9) Aggregate Amount Beneficially 6,966 shares of
Owned by Each Reporting person Common Stock
_________________________________________________________________
10) Check if the Aggregate
Amount in Row (9)
Excludes Certain Shares
_________________________________________________________________
11) Percent of Class
Represented by less than 0.1%
Amount in Row (9)
_________________________________________________________________
12) Type of Reporting
Person PN
<PAGE>
CUSIP No. 0008946991 Page 6 of 7 Pages
Amendment No. 1 to Schedule 13G
_______________________________
Reference is hereby made to the statement on Schedule 13G
originally filed on February 12, 1997 (the "Schedule 13G"). Terms defined
in the Schedule 13G are used herein as so defined.
The Schedule 13G is hereby amended as follows:
Item 1(a) - Name of Issuer: Trega Biosciences, Inc. (formerly
Houghten Pharmaceuticals, Inc.)
Item 2(d) - Title of Class of Securities:
Common Stock, $.001 par value ("Common Stock")
Item 2(e) - CUSIP Number: 0008946991
Item 4 - Ownership.
(a) Amount Beneficially Owned:
Domain II: 1,444,084 shares of Common Stock
Domain III: 1,086,633 shares of Common Stock
DP III A: 37,793 shares of Common Stock
DA: 6,966 shares of Common Stock
(b) Percent of Class:
Domain II: 10.4%
Domain III: 7.9%
DP III A: 0.3%
DA: less than 0.1%
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote:
Domain II: 1,444,084 shares of Common Stock
Domain III: 1,086,633 shares of Common Stock
DP III A: 37,793 shares of Common Stock
DA: 6,966 shares of Common Stock
(ii) shared power to vote or to direct the vote: -0-
(iii) sole power to dispose or to direct the disposition of:
Domain II: 1,444,084 shares of Common Stock
Domain III: 1,086,633 shares of Common Stock
DP III A: 37,793 shares of Common Stock
DA: 6,966 shares of Common Stock
(iv) shared power to dispose or to direct the disposition
of: -0-
<PAGE>
CUSIP No. 0008946991 Page 7 of 7 Pages
Signature:
After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.
DOMAIN PARTNERS II, L.P.
By: One Palmer Square Associates
II L.P., General Partner
By /s/ Kathleen K. Schoemaker
________________________________
Attorney-in-Fact
DOMAIN PARTNERS III, L.P.
By: One Palmer Square Associates
III L.P., General Partner
By /s/ Kathleen K. Schoemaker
________________________________
General Partner
DP III ASSOCIATES, L.P.
By: One Palmer Square Associates
III L.P., General Partner
By /s/ Kathleen K. Schoemaker
________________________________
General Partner
DOMAIN ASSOCIATES
By /s/ Kathleen K. Schoemaker
________________________________
General Partner
Date: February 2, 1998
