SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
________________________
SCHEDULE 13G
Information Statement pursuant to Rules 13d-1 and 13d-2
Under the Securities Exchange Act of 1934
(Amendment No. 1)
Trega Biosciences, Inc.
_________________________________________________________________
(Name of Issuer)
Common Stock, $.001 par value
_________________________________________________________________
(Title of Class of Securities)
0008946991
_________________________________________________________________
(CUSIP Number)
________________________
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CUSIP No. 0008946991 Page 2 of 6 Pages
_________________________________________________________________
1) Name of Reporting Person Biotechnology
S.S. or I.R.S. Identification Investments
No. of Above Person Limited
_________________________________________________________________
2) Check the Appropriate Box (a) [ ]
if a Member of a Group (b) [ ]
_________________________________________________________________
3) SEC Use Only
_________________________________________________________________
4) Citizenship or Place Guernsey,
of Organization Channel Islands
_________________________________________________________________
Number of 5) Sole Voting 1,486,831 shares of
Shares Beneficially Power Common Stock, $.001
Owned by Each par value ("Common
Reporting Person Stock")
________________________________________
6) Shared Voting
Power -0-
________________________________________
7) Sole Disposi- 1,486,831 shares of
tive Power Common Stock
________________________________________
8) Shared Dis-
positive Power -0-
________________________________________
9) Aggregate Amount Beneficially 1,486,831 shares of
Owned by Each Reporting Person Common Stock
_________________________________________________________________
10) Check if the Aggregate
Amount in Row (9)
Excludes Certain Shares
_________________________________________________________________
11) Percent of Class
Represented by 10.8%
Amount in Row (9)
_________________________________________________________________
12) Type of Reporting
Person CO
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CUSIP No. 0008946991 Page 3 of 6 Pages
Amendment No. 1 to Schedule 13G
_______________________________
Reference is hereby made to the statement on Schedule 13G
originally filed in February 1997 (the "Schedule 13G"). Terms defined in
the Schedule 13G are used herein as so defined.
The Schedule 13G is hereby amended as follows:
Item 1(a) - Name of Issuer: Trega Biosciences, Inc. (formerly Houghten
Pharmaceuticals, Inc.)
Item 2(d) - Title of Class of Securities:
Common Stock, $.001 par value ("Common Stock")
Item 2(e) - CUSIP Number: 0008946991
Item 4 - Ownership.
(a) Amount Beneficially Owned:
1,486,831 shares of Common Stock
(b) Percent of Class:
10.8%
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote:
1,486,831 shares
(ii) shared power to vote or to direct the vote: -0-
(iii) sole power to dispose or to direct the disposition
of: 1,486,831 shares
(iv) shared power to dispose or to direct the
disposition of: -0-
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CUSIP No. 0008946991 Page 4 of 6 Pages
Signature:
After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.
BIOTECHNOLOGY INVESTMENTS LIMITED
By: Old Court Limited
By /s/ Kathleen K. Schoemaker
______________________________
Attorney-in-Fact
Date: February 2, 1998
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CUSIP No. 0008946991 Page 5 of 6 Pages
OLD COURT LIMITED
P.O. Box 58, St. Julian's Court, St. Peter Port,
Guernsey, Channel Islands GYI 3BP
Our Ref: PF/domain/POA226
28 January 1998
____
Domain Associates
One Palmer Square
Princeton, New Jersey 08542
USA
Dear Sirs
BIOTECHNOLOGY INVESTMENTS LIMITED
We, Old Court Limited hereby authorise you to execute on behalf of Old
Court Limited a Schedule 13G to be filed with the Securities and Exchange
Commission regarding Biotechnology Investments Limited's holdings of Trega
Biosciences, Inc.
Yours very truly
per pro Old Court Limited
/s/ J.J. Nicolle /s/ S.E. Shaw
______________________ ___________________
J.J. Nicolle, Director S.E. Shaw, Director
We confirm that we have authorised Old Court Limited to grant the above
Power of Attorney.
Yours very truly
per pro Biotechnology Investments Limited
/s/ P.A.S. Firth
__________________________________
P.A.S. Firth, Authorised Signatory
<PAGE>
CUSIP No. 0008946991 Page 6 of 6 Pages
OLD COURT LIMITED
P.O. Box 58, St. Julian's Court, St. Peter Port,
Guernsey, Channel Islands GYI 3BP
Our Ref: PF/domain/POA81
28 January 1998
____
Domain Associates
One Palmer Square
Princeton, New Jersey 08542
USA
Dear Sirs
BIOTECHNOLOGY INVESTMENTS LIMITED
We, NM Rothschild & Sons (C.I.) Limited hereby authorise you to execute on
behalf of NM Rothschild & Sons (C.I.) Limited a Schedule 13G to be filed
with the Securities and Exchange Commission regarding Biotechnology
Investments Limited's holdings of Trega Biosciences, Inc.
Yours very truly
per pro NM Rothschild & Sons (C.I.) Limited
/s/ J.J. Nicolle /s/ A.J. Gallienne
____________________ ____________________
J.J. Nicolle A.J. Gallienne
Authorised Signatory Authorised Signatory
We confirm that we have authorised NM Rothschild & Sons (C.I.) Limited to
grant the above Power of Attorney.
Yours very truly
per pro Biotechnology Investments Limited
/s/ P.A.S. Firth
__________________________________
P.A.S. Firth, Authorised Signatory
