SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13D
UNDER THE SECURITIES EXCHANGE ACT OF 1934
(Amendment No. )
Trega Biosciences, Inc.
__________________________________________________________________
(Name of Issuer)
Common Stock, $.001 par value
___________________________________________________________________
(Title of Class of Securities)
0008946991
___________________________________________________________________
(CUSIP Number)
Kathleen K. SchoemakerJohn C. MacMurray, Esq.
Domain AssociatesReboul, MacMurray, Hewitt,
One Palmer Square Maynard & Kristol
Princeton, New Jersey 0854245 Rockefeller Plaza
Tel. (609) 683-5656New York, New York 10111
Tel. (212) 841-5700
___________________________________________________________________
(Name, Address and Telephone Number of Person
Authorized to Receive Notices and Communications)
March 27, 1998
________________________________
(Date of Event Which Requires
Filing of This Statement)
If the filing person has previously filed a statement on Schedule 13G to
report the acquisition which is the subject of this Schedule 13D, and is
filing this schedule because of Rule 13d-1(b)(3) or (4), check the
following box [ ].
<PAGE>
CUSIP No. 0008946991 Page 2 of 11
______________________________________________________________________
1)Name of Reporting PersonDomain Partners II,
S.S. or I.R.S. IdentificationL.P.
No. of Above Person
______________________________________________________________________
2)Check the Appropriate Box(a) [x]
if a Member of a Group(b) [ ]
______________________________________________________________________
3)SEC Use Only
______________________________________________________________________
4)Source of Funds WC
______________________________________________________________________
5) Check if Disclosure of
Legal Proceedings isNot Applicable
Required Pursuant to
Items 2(d) or 2(e)
______________________________________________________________________
6) Citizenship or Place
of Organization Delaware
______________________________________________________________________
Number of 7)Sole Voting 1,444,084 shares of
Shares Beneficially Power Common Stock
Owned by Each
Reporting Person:
_____________________________________________
8)Shared Voting
Power -0-
_____________________________________________
9)Sole Disposi-1,444,084 shares of
tive Power Common Stock
_____________________________________________
10) Shared Dis-
positive Power -0-
_____________________________________________
11) Aggregate Amount Beneficially 1,444,084 shares of
Owned by Each Reporting Person Common Stock
______________________________________________________________________
12) Check if the Aggregate
Amount in Row (11)
Excludes Certain Shares
______________________________________________________________________
13) Percent of Class
Represented by10.4%
Amount in Row (11)
______________________________________________________________________
14) Type of Reporting
PersonPN
CUSIP No. 0008946991 Page 3 of 11
1)Name of Reporting PersonDomain Partners III,
S.S. or I.R.S. IdentificationL.P.
No. of Above Person
_______________________________________________________________________
2)Check the Appropriate Box(a) [x]
if a Member of a Group(b) [ ]
_______________________________________________________________________
3)SEC Use Only
_______________________________________________________________________
Source of Funds WC
5) Check if Disclosure of
Legal Proceedings isNot Applicable
Required Pursuant to
Items 2(d) or 2(e)
_______________________________________________________________________
6) Citizenship or Place
of Organization Delaware
Number of 7)Sole Voting 1,316,273 shares of
Shares Beneficially Power Common Stock
Owned by Each
Reporting Person:
8)Shared Voting
Power -0-
9)Sole Disposi-1,316,273 shares of
tive Power Common Stock
______________________________________________
10) Shared Dis-
positive Power -0-
______________________________________________
11) Aggregate Amount Beneficially 1,316,273 shares of
Owned by Each Reporting Person Common Stock
_______________________________________________________________________
12) Check if the Aggregate
Amount in Row (11)
Excludes Certain Shares
_______________________________________________________________________
13) Percent of Class
Represented by9.5%
Amount in Row (11)
_______________________________________________________________________
14) Type of Reporting
Person PN
CUSIP No. 0008946991 Page 4 of 11
_________________________________________________________________
1)Name of Reporting PersonDP III Associates,
S.S. or I.R.S. Identification L.P.
No. of Above Person
_________________________________________________________________
2)Check the Appropriate Box(a) [x]
if a Member of a Group(b) [ ]
_________________________________________________________________
3)SEC Use Only
_________________________________________________________________
4) Source of FundsWC
_________________________________________________________________
5) Check if Disclosure of
Legal Proceedings isNot Applicable
Required Pursuant to
Items 2(d) or 2(e)
_________________________________________________________________
6) Citizenship or Place
of Organization Delaware
_________________________________________________________________
Number of 7)Sole Voting 45,703 shares of
Shares Beneficially Power Common Stock
Owned by Each
Reporting Person:
________________________________________
8) Shared Voting
Power -0-
________________________________________
9)Sole Disposi-45,703 shares of
tive Power Common Stock
________________________________________
10)Shared Dis-
positive Power-0-
________________________________________
11)Aggregate Amount Beneficially 45,703 shares of
Owned by Each Reporting Person Common Stock
_________________________________________________________________
12)Check if the Aggregate
Amount in Row (11)
Excludes Certain Shares
_________________________________________________________________
13) Percent of Class
Represented by0.3%
Amount in Row (11)
_________________________________________________________________
14) Type of Reporting
Person PN
CUSIP No. 0008946991 Page 5 of 11
_________________________________________________________________
1)Name of Reporting PersonDomain Associates
S.S. or I.R.S. Identification
No. of Above Person
_________________________________________________________________
2)Check the Appropriate Box(a) [x]
if a Member of a Group(b) [ ]
_________________________________________________________________
3)SEC Use Only
_________________________________________________________________
4) Source of FundsNot Applicable
_________________________________________________________________
5) Check if Disclosure of
Legal Proceedings isNot Applicable
Required Pursuant to
Items 2(d) or 2(e)
_________________________________________________________________
6) Citizenship or Place
of Organization New Jersey
_________________________________________________________________
Number of 7)Sole Voting 6,966 shares of
Shares Beneficially Power Common Stock
Owned by Each
Reporting Person:
________________________________________
8) Shared Voting
Power -0-
________________________________________
9)Sole Disposi-6,966 shares of
tive Power Common Stock
________________________________________
10)Shared Dis-
positive Power-0-
________________________________________
11)Aggregate Amount Beneficially 6,966 shares of
Owned by Each Reporting Person Common Stock
_________________________________________________________________
12)Check if the Aggregate
Amount in Row (11)
Excludes Certain Shares
_________________________________________________________________
13) Percent of Class
Represented byless than 0.1%
Amount in Row (11)
_________________________________________________________________
14) Type of Reporting
Person PN
CUSIP No. 0008946991 Page 6 of 11
Schedule 13D
_____________
Item 1.Security and Issuer.
___________________
This statement relates to the Common Stock, $.001 par value (the
"Common Stock"), of Trega Biosciences, Inc., a Delaware corporation (the
"Issuer"). The principal executive offices of the Issuer are located at
3550 General Atomics Court, San Diego, California 92121.
Item 2. Identity and Background.
_______________________
(a) Pursuant to Rules 13d-1(f)(1)-(2) of Regulation 13D-G of the
General Rules and Regulations under the Securities Act of 1934, as amended
(the "Act"), the undersigned hereby file this Schedule 13D on behalf of
Domain Partners II L.P. ("DP II"), Domain Partners III, L.P., a Delaware
limited partnership ("DP III"), DP III Associates, L.P., a Delaware limited
partnership ("DPA") and Domain Associates, a New Jersey general partnership
("DA"). DP II, DP III, DPA and DA are sometimes hereinafter referred to as
the "Reporting Persons". The Reporting Persons are making this single
joint filing because they may be deemed to constitute a "group" within the
meaning of Section 13(d)(3) of the Act. The agreement among the Reporting
Persons to file as a group (the "Group Agreement") is attached hereto as
Exhibit A.
(b)-(c) DA is a New Jersey general partnership, whose principal
business is that of an investment manager. DP II, DP III and DPA are
Delaware limited partnerships, whose principal businesses are those of
private investment partnerships. The sole general partner of DP II is One
Palmer Square Associates II, L.P., a Delaware limited partnership
("OPSA II"), whose principal business is that of acting as the general
partner of DP II. The sole general partner of DP III and DPA is One Palmer
Square Associates III, L.P., a Delaware limited partnership ("OPSA III"),
whose principal business is that of acting as the general partner of DP III
and DPA. The following individuals, who are citizens of the United States,
are the general partners of the entities listed after their names:
(i) James C. Blair - DA, OPSA II and OPSA III
(ii) Brian H. Dovey - DA, OPSA II and OPSA III
(iii) Jesse I. Treu - DA, OPSA II and OPSA III
(iv) Richard S. Schneider - DA, OPSA II and OPSA III
(v) Kathleen K. Schoemaker - DA and OPSA III
(vi)Arthur Klausner - DA
The principal business and principal office address of each
entity and individual named in this paragraph is One Palmer Square,
Princeton, New Jersey 08542.
CUSIP No. 0008946991 Page 7 of 11
(d) None of the entities or persons identified in this Item 2
has, during the last five years, been convicted in a criminal proceeding
(excluding traffic violations or similar misdemeanors).
(e) None of the entities or persons identified in this Item 2
has, during the last five years, been a party to a civil proceeding of a
judicial or administrative body of competent jurisdiction and as a result
of such proceeding was or is subject
to a judgment, decree or final order enjoining future violations of, or
prohibiting or mandating activities subject to, federal or state securities
laws or finding any violation with respect to such laws.
Item 3. Source and Amount of Funds or Other Consideration.
_________________________________________________
This statement relates to the acquisition by DP III and DPA on
March 2, 1998 through March 27, 1998 of an aggregate 237,550 shares of
Common Stock at prices ranging from $3.56 to $5.01 per share, in open
market purchases as further described in Item 5(c) below. The source of
such funds was the working capital of DP III and DPA.
Item 4. Purpose of Transaction.
______________________
The Reporting Persons have acquired securities of the Issuer for
investment purposes.
Item 5. Interest in Securities of the Issuer.
____________________________________
The following information is based on a total of 13,927,098
shares of Common Stock outstanding as of March 20, 1998, as reported in the
Issuer's Annual Report on Form 10-K for the calendar year ended December
31, 1997.
(a)
DP II
_____
DP II owns an aggregate 1,444,084 shares of Common Stock, or
approximately 10.4% of the Common Stock outstanding.
<PAGE>
CUSIP No. 0008946991 Page 8 of 11
OPSA II
_______
OPSA II, as the general partner of DP II, may be deemed to
beneficially own the 1,444,084 shares of Common Stock owned by DP II,
or approximately 10.4% of the Common Stock outstanding.
DP III
______
DP III owns an aggregate 1,316,273 shares of Common Stock, or
approximately 9.5% of the Common Stock outstanding.
DPA
___
DPA owns an aggregate 45,703 shares of Common Stock, or
approximately 0.3% of the Common Stock outstanding.
OPSA III
________
OPSA III, as the general partner of DP III and DPA, may be deemed
to beneficially own the aggregate 1,361,976 shares of Common Stock
owned by DP III and DPA, or approximately 9.8% of the Common Stock
outstanding.
DA
__
DA owns an aggregate 6,966 shares of Common Stock, or less than
0.1% of the Common Stock outstanding.
(b) The general partners of OPSA II, OPSA III and DA may be
deemed to share the power to vote or direct the voting of and to dispose or
to direct the disposition of the shares of Common Stock owned by DP II,
DP III, DPA and DA. Each of the general partners of OPSA II, OPSA III and
DA disclaims beneficial ownership of all shares of Common Stock other than
the shares of Common Stock he or she owns by virtue of his or her indirect
pro rata interest, as a partner of OPSA II, OPSA III and DA, in the Common
Stock owned by DP II, DP III, DPA and DA.
<PAGE>
CUSIP No. 0008946991 Page 9 of 11
(c) In the last sixty days DP III and DPA have purchased Common
Stock in market transactions as follows:
PurchaserDateNumber of SharesPrice per Share
DP III3/02/98 7,250$3.56
DP III3/03/98 9,667$3.56
DP III3/04/98 4,835$3.56
DP III3/06/98 9,677$3.75
DP III3/09/9862,835$4.04
DP III3/10/9829,000$4.12
DP III3/11/9829,000$4.12
DP III3/12/98 9,677$4.06
DP III3/16/9819,334$3.98
DP III3/19/98 9,677$4.06
DP III3/20/98 9,677 $4.50
DP III3/24/9819,334$4.75
DP III3/27/9819,677$5.00
DPA 3/02/98 250$3.58
DPA3/03/98 333$3.57
DPA3/04/98 165$3.59
DPA3/06/98 333$3.76
DPA3/09/98 2,165$4.04
DPA3/10/98 1,000$4.13
DPA3/11/98 1,000$4.13
DPA3/12/98 333$4.07
DPA3/16/98 666$3.99
DPA3/19/98 333$4.07
DPA3/20/98 333$4.51
DPA3/24/98 666$4.76
DPA3/27/98 333$5.01
(d) Except as described in this statement, no person has the
power to direct the receipt of dividends on, or the proceeds from sales of,
the shares of Common Stock owned by DP II, DP III, DPA or DA.
(e)Not applicable.
Item 6. Contracts, Arrangements, Understandings
or Relationships with Respect to
Securities of the Issuer.
_______________________________________
Not Applicable.
Item 7. Material to be Filed as Exhibits.
________________________________
Exhibit A - Group Agreement (Appears at Page 12)
CUSIP No. 0008946991 Page 10 of 11
Signature
_________
After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.
Dated: April 22, 1998
DOMAIN PARTNERS II, L.P.
By: One Palmer Square Associates
II L.P., General Partner
By /s/ Kathleen K. Schoemaker
___________________________________
Attorney-in-Fact
DOMAIN PARTNERS III, L.P.
By: One Palmer Square Associates
III L.P., General Partner
By /s/ Kathleen K. Schoemaker
____________________________________
General Partner
DP III ASSOCIATES, L.P.
By: One Palmer Square Associates III
L.P., General Partner
By /s/ Kathleen K. Schoemaker
_____________________________________
General Partner
DOMAIN ASSOCIATES
By /s/ Kathleen K. Schoemaker
______________________________________
General Partner
<PAGE>
CUSIP No. 0008946991 Page 11 of 11
EXHIBIT A
AGREEMENT OF
DOMAIN PARTNERS II, L.P.,
DOMAIN PARTNERS III, L.P.,
DP III ASSOCIATES, L.P.
AND
DOMAIN ASSOCIATES
PURSUANT TO RULE 13d-1(f)
_____________________
The undersigned hereby agree that the Statement on Schedule 13D
to which this Agreement is annexed as Exhibit A is filed on behalf of each
of them in accordance with the provisions of 13d-1(f) under the Securities
Exchange Act of 1934, as amended.
DOMAIN PARTNERS II, L.P.
By: One Palmer Square Associates
II L.P., General Partner
By /s/ Kathleen K. Schoemaker
___________________________________
Attorney-in-Fact
DOMAIN PARTNERS III, L.P.
By: One Palmer Square Associates
III L.P., General Partner
By /s/ Kathleen K. Schoemaker
__________________________________
General Partner
DP III ASSOCIATES, L.P.
By: One Palmer Square Associates
III L.P., General Partner
By /s/ Kathleen K. Schoemaker
__________________________________
General Partner
DOMAIN ASSOCIATES
By /s/ Kathleen k. Schoemaker
__________________________________
General Partner
Date: April 22, 1998
