MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
485BPOS, 1999-09-24
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<PAGE>

  AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON SEPTEMBER 24, 1999
                                                    REGISTRATION NOS.: 33-48189
                                                                       811-6683

- --------------------------------------------------------------------------------

                      SECURITIES AND EXCHANGE COMMISSION


                             WASHINGTON, D.C. 20549

                               ----------------

                                   FORM N-1A
                            REGISTRATION STATEMENT
                        UNDER THE SECURITIES ACT OF 1933         [X]
                          PRE-EFFECTIVE AMENDMENT NO.            [ ]
                        POST-EFFECTIVE AMENDMENT NO. 10          [X]
                                     AND/OR
              REGISTRATION STATEMENT UNDER THE INVESTMENT COMPANY
                                  ACT OF 1940                    [X]
                                AMENDMENT NO. 11                 [X]

                               ----------------

               MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
                       (A MASSACHUSETTS BUSINESS TRUST)
              (EXACT NAME OF REGISTRANT AS SPECIFIED IN CHARTER)

                            TWO WORLD TRADE CENTER
                           NEW YORK, NEW YORK 10048
                    (ADDRESS OF PRINCIPAL EXECUTIVE OFFICE)

      REGISTRANT'S TELEPHONE NUMBER, INCLUDING AREA CODE: (212) 392-1600
                               BARRY FINK, ESQ.
                            TWO WORLD TRADE CENTER
                           NEW YORK, NEW YORK 10048
                    (NAME AND ADDRESS OF AGENT FOR SERVICE)

                                   Copy to:
                            STUART M. STRAUSS, ESQ.
                              MAYER, BROWN & PLATT
                                 1675 BROADWAY
                         NEW YORK, NEW YORK 10019-5820

                               ----------------

                 APPROXIMATE DATE OF PROPOSED PUBLIC OFFERING:


 As soon as practicable after this Post-Effective Amendment becomes effective.

 IT IS PROPOSED THAT THIS FILING WILL BECOME EFFECTIVE (CHECK APPROPRIATE BOX)


                         immediately upon filing pursuant to paragraph (b)
                  -----
                    X    on September 27, 1999 pursuant to paragraph (b)
                  -----
                         60 days after filing pursuant to paragraph (a)
                  -----
                         on (date) pursuant to paragraph ( ) of rule 485.
                  -----

                               ----------------

           AMENDING THE PROSPECTUS AND UPDATING FINANCIAL STATEMENTS
- --------------------------------------------------------------------------------
<PAGE>




                                            PROSPECTUS - SEPTEMBER 27, 1999

Morgan Stanley Dean Witter

              ----------------------------------------------------------------
                                                          HEALTH SCIENCES TRUST















                                  A MUTUAL FUND THAT SEEKS CAPITAL APPRECIATION



  The Securities and Exchange Commission has not approved or disapproved these
securities or passed upon the adequacy of this Prospectus. Any representation to
the contrary is a criminal offense.


<PAGE>





CONTENTS


<TABLE>
<S>                         <C>
The Fund                    Investment Objective ............................ 1
                            Principal Investment Strategies ................. 1
                            Principal Risks ................................. 2
                            Past Performance ................................ 4
                            Fees and Expenses ............................... 5
                            Additional Investment Strategy Information ...... 6
                            Additional Risk Information ..................... 7
                            Fund Management ................................. 8
Shareholder Information     Pricing Fund Shares ............................. 9
                            How to Buy Shares ............................... 9
                            How to Exchange Shares ..........................11
                            How to Sell Shares ..............................13
                            Distributions ...................................15
                            Tax Consequences ................................15
                            Share Class Arrangements ........................16
Financial Highlights        .................................................24
Our Family of Funds         .................................................Inside Back Cover

                            This Prospectus contains important information about the Fund.
                            Please read it carefully and keep it for future reference.
</TABLE>



<PAGE>



THE FUND


[GRAPHIC OMITTED]

      INVESTMENT OBJECTIVE
- --------------------------------
          Morgan Stanley Dean Witter Health Sciences Trust seeks capital
          appreciation.


[GRAPHIC OMITTED]

      PRINCIPAL INVESTMENT STRATEGIES
- --------------------------------------------
[sidebar]
CAPITAL APPRECIATION
An investment objective having the goal of selecting securities with the
potential to rise in price rather than pay out income.
[end sidebar]
- ----------------------

          The Fund will normally invest at least 65% of its total assets in
          common stocks (including depository receipts) of health science
          companies throughout the world. A company will be considered to be a
          health science company if it derives at least 50% of its earnings or
          revenues, or it devotes at least 50% of its assets, to health science
          activities. Health science companies include, among others:


          o  hospitals, clinical test laboratories, convalescent and mental
             health care facilities and home care businesses;

          o  pharmaceutical companies and companies involved in biotechnology,
             medical diagnostics, biochemicals, and nuclear research and
             development;

          o  companies that produce and manufacture medical, dental and optical
             supplies and equipment;

          o  companies that provide services to health care companies; and

          o  HMOs and other health insurance companies.



          In deciding which securities to buy, hold or sell, the Fund's
          "Investment Manager," Morgan Stanley Dean Witter Advisors Inc.,
          invests in companies based on its view of business, economic and
          political conditions. The Investment Manager will apply a fundamental
          analysis seeking to identify the securities it believes are most
          attractive investments based on its assessment of a company's
          business models, products and financial outlook, as well as an
          assessment of the general economic climate and the political
          environment.


          Common stock is a share ownership or equity interest in a
          corporation. It may or may not pay dividends, as some companies
          reinvest all of their profits back into their businesses, while
          others pay out some of their profits to shareholders as dividends. A
          depository receipt is generally issued by a bank or financial
          institution and represents an ownership interest in the common stock
          or other equity securities of a foreign company.



          In addition, the Fund may invest in the common stock of non-health
          science companies, preferred stock and investment grade fixed-income
          securities.


          In pursuing the Fund's investment objective, the Investment Manager
          has considerable leeway in deciding which investments it buys, holds
          or sells on a day-to-day basis -- and


                                                                               1

<PAGE>


          which trading strategies it uses. For example, the Investment Manager
          in its discretion may determine to use some permitted trading
          strategies while not using others.




[GRAPHIC OMITTED]

      PRINCIPAL RISKS
- --------------------------
          There is no assurance that the Fund will achieve its investment
          objective. The Fund's share price will fluctuate with changes in the
          market value of the Fund's portfolio securities. When you sell Fund
          shares, they may be worth less than what you paid for them and,
          accordingly, you can lose money investing in this Fund.

          Common Stocks. In general, stock values fluctuate in response to
          activities specific to the company as well as general market,
          economic and political conditions. These prices can fluctuate widely.

          Health Sciences Industry. The Fund concentrates its investments in
          the health sciences industry. Because of this concentration, the
          value of the Fund's shares may be more volatile than mutual funds
          that do not similarly concentrate their investments. The health
          sciences industry is subject to substantial regulation and could be
          materially adversely effected by changes in governmental regulations.
          Additionally, the products and services of companies in this industry
          may be subject to faster obsolescence as a result of greater
          competition and advancing technological developments. As a result,
          the securities of companies in this industry may exhibit greater
          price volatility than those of companies in other industries.


          The Fund may invest in smaller (generally companies with market
          capitalization under $1 billion) health science companies which
          involve greater risks, than large or more established issuers. These
          smaller companies may have limited product lines, markets or
          financial resources, and their securities may trade less frequently
          and in more limited volume than the securities of larger, more
          established companies. As a result, the prices of the securities of
          smaller companies may fluctuate to a greater degree than the prices
          of the securities of other issuers.


          Foreign Securities. The Fund's investments in foreign securities
          (including depository receipts) involve risks that are in addition to
          the risks associated with domestic securities. One additional risk is
          currency risk. While the price of Fund shares is quoted in U.S.
          dollars, the Fund generally converts U.S. dollars to a foreign
          market's local currency to purchase a security in that market. If the
          value of that local currency falls relative to the U.S. dollar, the
          U.S. dollar value of the foreign security will decrease. This is true
          even if the foreign security's local price remains unchanged.

          Foreign securities also have risks related to economic and political
          developments abroad, including expropriations, confiscatory taxation,
          exchange control regulation, limitations on the use or transfer of
          Fund assets and any effects of foreign social, economic or political
          instability. Foreign companies, in general, are not subject to the


2

<PAGE>



          regulatory requirements of U.S. companies and, as such, there may be
          less publicly available information about these companies. Moreover,
          foreign accounting, auditing and financial reporting standards
          generally are different from those applicable to U.S. companies.
          Finally, in the event of a default of any foreign debt obligations,
          it may be more difficult for the Fund to obtain or enforce a judgment
          against the issuers of the securities.



          Securities of foreign issuers may be less liquid than comparable
          securities of U.S. issuers and, as such, their price changes may be
          more volatile. Furthermore, foreign exchanges and broker-dealers are
          generally subject to less government and exchange scrutiny and
          regulation than their U.S. counterparts. In addition, differences in
          clearance and settlement procedures in foreign markets may occasion
          delays in settlements of the Fund's trades effected in those markets.
          Delays in purchasing securities may result in the Fund losing
          investment opportunities. The inability to dispose of foreign
          securities due to settlement delays could result in losses to the
          Fund due to subsequent declines in value of the securities.


          Many European countries have adopted, or are in the process of
          adopting, a single European currency, referred to as the "euro." The
          long-term consequences of the euro conversion for foreign exchange
          rates, interest rates and the value of European securities the Fund
          may purchase are unclear. The consequences may adversely affect the
          value and/or increase the volatility of securities held by the Fund.



          Other Risks. The performance of the Fund also will depend on whether
          the Investment Manager is successful in pursuing the Fund's
          investment strategy. The Fund is also subject to other risks from its
          permissible investments including the risks associated with its
          fixed-income investments.


          Shares of the Fund are not bank deposits and are not guaranteed or
          insured by the FDIC or any other government agency.


                                                                               3

<PAGE>



[GRAPHIC OMITTED]

      PAST PERFORMANCE
- ----------------------------


          The bar chart and table below provide some indication of the risks of
          investing in the Fund. The Fund's past performance does not indicate
          how the Fund will perform in the future.

[sidebar]
ANNUAL TOTAL RETURNS
This chart shows how the performance of the Fund's Class B shares has varied
from year to year over the past 6 calendar years.
[end sidebar]

                          ANNUAL TOTAL RETURNS -- CALENDAR YEARS

                               [GRAPHIC OMITTED]


 1993        '94        '95       '96        '97       '98

5.63%      -6.50%      62.30%    1.17%      5.54%     18.24%





The bar chart reflects the performance of Class B shares; the performance of the
other Classes will differ because the Classes have different ongoing fees. The
performance information in the bar chart does not reflect the deduction of sales
charges; if these amounts were reflected, returns would be less than shown.
Year-to-date total return as of June 30, 1999 was -2.66%.




          During the periods shown in the bar chart, the highest return for a
          calendar quarter was 18.97% (quarter ended December 31, 1995) and the
          lowest return for a calendar quarter was -17.75% (quarter ended March
          31, 1993).

[sidebar]
AVERAGE ANNUAL TOTAL RETURNS
This table compares the Fund's average annual returns with those of a broad
measure of market performance over time, as well as with an index of funds with
similar investment objectives. The Fund's returns include the maximum
applicable sales charge for each Class and assume you sold your shares at the
end of each period.
[end sidebar]



             AVERAGE ANNUAL TOTAL RETURNS (AS OF DECEMBER 31, 1998)


<TABLE>
<CAPTION>
                                                                    LIFE OF THE FUND
                                       PAST 1 YEAR   PAST 5 YEARS   (SINCE 10/30/92)
<S>                                   <C>           <C>            <C>
  Class A(1)                          12.63%             N/A               --
  Class B                             13.56%           13.65%            12.96%
  Class C(1)                          17.31%             N/A               --
  Class D(1)                          19.19%             N/A               --
  S&P 500 Index(2)                    28.58%           24.05%            21.83%
  Lipper Health/Biotechnology Funds
  Index(3)                            26.00%           21.23%            18.57%
</TABLE>


1  Classes A, C and D commenced operations on July 28, 1997.

2  The Standard & Poor's (Registered Trademark) 500 Composite Stock Price Index
   is a broad-based index, the performance of which is based on the average
   performance of 500 widely held common stocks. The performance of the Index
   does not include any expenses, fees or charges. The Index is unmanaged and
   should not be considered an investment.

3  The Lipper Health/Biotechnology Funds Index is an equally-weighted
   performance index of the largest qualifying funds (based on net assets) in
   the Lipper Health/Biotechnology Funds objective. The Index, which is adjusted
   for capital gains distributions and income dividends, is unmanaged and should
   not be considered an investment. There are currently 10 funds represented in
   this Index.



4

<PAGE>




[GRAPHIC OMITTED]

      FEES AND EXPENSES
- -----------------------------
          The table below briefly describes the fees and expenses that you may
          pay if you buy and hold shares of the Fund. The Fund offers four
          Classes of shares: Classes A, B, C and D. Each Class has a different
          combination of fees, expenses and other features. The Fund does not
          charge account or exchange fees. See the "Share Class Arrangements"
          section for further fee and expense information.

[sidebar]
SHAREHOLDER FEES
These fees are paid directly from
your investment.
[end sidebar]


[sidebar]
ANNUAL FUND
OPERATING EXPENSES
These expenses are deducted
from the Fund's assets and are
based on expenses paid for the
fiscal year ended July 31, 1999.
[end sidebar]


<TABLE>
<CAPTION>
                                                     CLASS A       CLASS B       CLASS C      CLASS D
<S>                                               <C>           <C>           <C>           <C>
  SHAREHOLDER FEES
  Maximum sales charge (load) imposed on
  purchases (as a percentage of offering price)     5.25%(1)      None          None          None
  Maximum deferred sales charge (load) (as a
  percentage based on the lesser of the offering
  price or net asset value at redemption)           None(2)       5.00%(3)      1.00%(4)      None
  ANNUAL FUND OPERATING EXPENSES
  Management fee                                    1.00%         1.00%         1.00%         1.00%
  Distribution and service (12b-1) fees             0.20%         1.00%         1.00%         None
  Other expenses                                    0.27%         0.27%         0.27%         0.27%
  Total annual Fund operating expenses              1.47%         2.47%         2.27%         1.27%
</TABLE>




1  Reduced for purchases of $25,000 and over.

2  Investments that are not subject to any sales charge at the time of purchase
   are subject to a CDSC of 1.00% that will be imposed if you sell your shares
   within one year after purchase, except for certain specific circumstances.

3  The CDSC is scaled down to 1.00% during the sixth year, reaching zero
   thereafter. See "Share Class Arrangements" for a complete discussion of the
   CDSC.

4  Only applicable if you sell your shares within one year after purchase.


          EXAMPLE

          This example is intended to help you compare the cost of investing in
          the Fund with the cost of investing in other mutual funds.


          The example assumes that you invest $10,000 in the Fund, your
          investment has a 5% return each year, and the Fund's operating
          expenses remain the same. Although your actual costs may be higher or
          lower, the tables below show your costs at the end of each period
          based on these assumptions depending upon whether or not you sell
          your shares at the end of each period.


                                                                               5

<PAGE>





<TABLE>
<CAPTION>
              IF YOU SOLD YOUR SHARES:                     IF YOU HELD YOUR SHARES:
            ----------------------------            --------------------------------------
            1 YEAR   3 YEARS   5 YEARS   10 YEARS   1 YEAR   3 YEARS   5 YEARS   10 YEARS
- ----------- -------- --------- --------- ------     -------- --------- --------- ---------
<S>         <C>      <C>       <C>       <C>        <C>      <C>       <C>       <C>
  CLASS A   $667     $965      $1,286    $2,190     $667     $965      $1,286    $2,190
- ----------- ----     ------    ------    ------     ----     ----      ------    ------
  CLASS B   $730     $1,009    $1,415    $2,605     $230     $709      $1,215    $2,605
- ----------- ----     ------    ------    ------     ----     ----      ------    ------
  CLASS C   $330     $709      $1,215    $2,605     $230     $709      $1,215    $2,605
- ----------- ----     ------    ------    ------     ----     ----      ------    ------
  CLASS D   $129     $403      $697      $1,534     $129     $403      $697      $1,534
- ----------- ----     ------    ------    ------     ----     ----      ------    ------
</TABLE>

          Long-term shareholders of Class B and Class C may pay more in sales
          charges, including distribution fees, than the economic equivalent of
          the maximum front-end sales charges permitted by the National
          Association of Securities Dealers.



[GRAPHIC OMITTED]

      ADDITIONAL INVESTMENT STRATEGY INFORMATION
- ---------------------------------------------------------
          This section provides additional information relating to the Fund's
          principal strategies.


          Fixed-Income Securities. The Fund may invest up to 35% of its total
          assets in preferred stock and investment grade debt securities.


          Defensive Investing. The Fund may take temporary "defensive"
          positions in attempting to respond to adverse market conditions. The
          Fund may invest any amount of its assets in cash or money market
          instruments in a defensive posture when the Investment Manager
          believes it is advisable to do so. Although taking a defensive
          posture is designed to protect the Fund from an anticipated market
          downturn, it could have the effect of reducing the benefit from any
          upswing in the market. When the Fund takes a defensive position, it
          may not achieve its investment objective.


          Portfolio Turnover. The Fund may engage in active and frequent
          trading of portfolio securities to achieve its principal investment
          strategies. The portfolio turnover rate is not expected to exceed
          200% annually under normal circumstances. A high turnover rate, such
          as 200%, will increase Fund brokerage costs. It also may increase the
          Fund's capital gains, which are passed along to Fund shareholders as
          distributions. This, in turn may increase your tax liability as a
          Fund shareholder. See the sections on "Distributions" and "Tax
          Consequences."



          The percentage limitations relating to the composition of the Fund's
          portfolio apply at the time the Fund acquires an investment and refer
          to the Fund's net assets, unless otherwise noted. Subsequent
          percentage changes that result from market fluctuations will not
          require the Fund to sell any portfolio security. The Fund may change
          its principal investment strategies without shareholder approval;
          however, you would be notified of any changes.



6

<PAGE>



[GRAPHIC OMITTED]

      ADDITIONAL RISK INFORMATION
- ----------------------------------------
          This section provides additional information relating to the
          principal risks of investing in the Fund.


          Fixed-Income Securities. Principal risks of investing in the Fund are
          also associated with its fixed-income securities. All fixed-income
          securities are subject to two types of risk: credit risk and interest
          rate risk.


          Credit risk refers to the possibility that the issuer of a security
          will be unable to make interest payments and/or repay the principal
          on its debt. While the Fund may invest in investment grade
          securities, certain of these securities have speculative credit
          characteristics.


          Interest rate risk refers to fluctuations in the value of a
          fixed-income security resulting from changes in the general level of
          interest rates. When the general level of interest rates goes up, the
          prices of most fixed-income securities go down. When the general
          level of interest rates goes down, the prices of most fixed-income
          securities go up.


          Year 2000. The Fund could be adversely affected if the computer
          systems necessary for the efficient operation of the Investment
          Manager, the Fund's other service providers and the markets and
          corporate and governmental issuers in which the Fund invests do not
          properly process and calculate date-related information from and
          after January 1, 2000. While year 2000-related computer problems
          could have a negative effect on the Fund, the Investment Manager and
          its affiliates are working hard to avoid any problems and to obtain
          assurances from their service providers that they are taking similar
          steps.


          In addition, it is possible that the markets for securities in which
          the Fund invests may be detrimentally affected by computer failures
          throughout the financial services industry beginning January 1, 2000.
          Improperly functioning trading systems may result in settlement
          problems and liquidity issues. Corporate and governmental data
          processing errors also may result in production problems for
          individual companies and overall economic uncertainties. Earnings of
          individual issuers will be affected by remediation costs, which may
          be substantial and may be reported inconsistently in U.S. and foreign
          financial statements. Accordingly, the Fund's investments may be
          adversely affected.


                                                                               7

<PAGE>





[GRAPHIC OMITTED]


       FUND MANAGEMENT
- ----------------------------
[sidebar]
MORGAN STANLEY DEAN WITTER ADVISORS INC.
The Investment Manager is widely recognized as a leader in the mutual fund
industry and together with Morgan Stanley Dean Witter Services Company Inc.,
its wholly-owned subsidiary, has more than $136 billion in assets under
management or administration as of August 31, 1999.
[end sidebar]


                        The Fund has retained the Investment Manager -- Morgan
                        Stanley Dean Witter Advisors Inc. -- to provide
                        administrative services, manage its business affairs and
                        invest its assets, including the placing of orders for
                        the purchase and sale of portfolio securities. The
                        Investment Manager is a wholly-owned subsidiary of
                        Morgan Stanley Dean Witter & Co., a preeminent global
                        financial services firm that maintains leading market
                        positions in each of its three primary businesses:
                        securities, asset management and credit services. Its
                        main business office is located at Two World Trade
                        Center, New York, NY 10048.


                        The Fund's portfolio is managed within the Investment
                        Manager's Growth Group. Teresa McRoberts, Vice President
                        of the Investment Manager, has been the primary
                        portfolio manager since December 31, 1998. Ms. McRoberts
                        has been a portfolio manager with the Investment Manager
                        since June 1, 1998, prior to which she was employed at
                        Fred Alger Management, Inc. (July 1994-May 1998).



                        The Fund pays the Investment Manager a monthly
                        management fee as full compensation for the services and
                        facilities furnished to the Fund, and for Fund expenses
                        assumed by the Investment Manager. The fee is based on
                        the Fund's average daily net assets. For the fiscal year
                        ended July 31, 1999, the Fund accrued total compensation
                        to the Investment Manager amounting to 1.00% of the
                        Fund's average daily net assets.



8

<PAGE>



SHAREHOLDER INFORMATION


[GRAPHIC OMITTED]

       PRICING FUND SHARES
- -------------------------------
          The price of Fund shares (excluding sales charges), called "net asset
          value," is based on the value of the Fund's portfolio securities.
          While the assets of each Class are invested in a single portfolio of
          securities, the net asset value of each Class will differ because the
          Classes have different ongoing distribution fees.


          The net asset value per share of the Fund is determined once daily at
          4:00 p.m. Eastern time, on each day that the New York Stock Exchange
          is open (or, on days when the New York Stock Exchange closes prior to
          4:00 p.m., at such earlier time). Shares will not be priced on days
          that the New York Stock Exchange is closed.


          The value of the Fund's portfolio securities is based on the
          securities' market price when available. When a market price is not
          readily available, including circumstances under which the Investment
          Manager determines that a security's market price is not accurate, a
          portfolio security is valued at its fair value, as determined under
          procedures established by the Fund's Board of Trustees. In these
          cases, the Fund's net asset value will reflect certain portfolio
          securities' fair value rather than their market price.


          An exception to the Fund's general policy of using market prices
          concerns its short-term debt portfolio securities. Debt securities
          with remaining maturities of sixty days or less at the time of
          purchase are valued at amortized cost. However, if the cost does not
          reflect the securities' market value, these securities will be valued
          at their fair value.




[GRAPHIC OMITTED]


      HOW TO BUY SHARES
- ------------------------------
[sidebar]
CONTACTING A FINANCIAL ADVISOR
If you are new to the Morgan Stanley Dean Witter Family of Funds and would like
to contact a Financial Advisor, call (800) THE-DEAN for the telephone number of
the Morgan Stanley Dean Witter office nearest you. You may also access our
office locator on our Internet site at: www.msdw.com/individual/funds
[end sidebar]


                        You may open a new account to buy Fund shares or buy
                        additional Fund shares for an existing account by
                        contacting your Morgan Stanley Dean Witter Financial
                        Advisor or other authorized financial representative.
                        Your Financial Advisor will assist you, step-by-step,
                        with the procedures to invest in the Fund. You may also
                        purchase shares directly by calling the Fund's transfer
                        agent and requesting an application.

                        Because every investor has different immediate financial
                        needs and long-term investment goals, the Fund offers
                        investors four Classes of shares: Classes A, B, C and D.
                        Class D shares are only offered to a limited group of
                        investors. Each Class of shares offers a distinct
                        structure of sales charges, distribution and service
                        fees, and other features that are designed to address a
                        variety of needs. Your Financial Advisor or other
                        authorized financial representative can help you decide
                        which Class may be most appropriate for you. When
                        purchasing Fund shares, you must specify which Class of
                        shares you wish to purchase.


                                                                               9

<PAGE>



          When you buy Fund shares, the shares are purchased at the next share
          price calculated (less any applicable front-end sales charge for
          Class A shares) after we receive your purchase order. Your payment is
          due on the third business day after you place your purchase order. We
          reserve the right to reject any order for the purchase of Fund
          Shares.


[sidebar]
EASYINVEST(SM)
A purchase plan that allows you to transfer money automatically from your
checking or savings account or from a Money Market Fund on a semi-monthly,
monthly or quarterly basis. Contact your Morgan Stanley Dean Witter Financial
Advisor for further information about this service.
[end sidebar]

                          MINIMUM INVESTMENT AMOUNTS
<TABLE>
<CAPTION>
                                                                            MINIMUM INVESTMENT
                                                                            ------------------
INVESTMENT OPTIONS                                                      INITIAL         ADDITIONAL
<S>                                               <C>                   <C>               <C>
  Regular Accounts                                                      $1,000            $100
  Individual Retirement Accounts:                    Regular IRAs       $1,000            $100
                                                     Education IRAs     $500              $100
  EasyInvest(SM)
  (Automatically from your checking or savings
  account or Money Market Fund)                                         $100*             $100*
</TABLE>

*  Provided your schedule of investments totals $1,000 in twelve months.


          There is no minimum investment amount if you purchase Fund shares
          through: (1) the Investment Manager's mutual fund asset allocation
          plan, (2) a program, approved by the Fund's distributor, in which you
          pay an asset-based fee for advisory, administrative and/or brokerage
          services, or (3) employer-sponsored employee benefit plan accounts.


          Investment Options for Certain Institutional and Other
          Investors/Class D Shares. To be eligible to purchase Class D shares,
          you must qualify under one of the investor categories specified in
          the "Share Class Arrangements" section of this Prospectus.


          Subsequent Investments Sent Directly to the Fund. In addition to
          buying additional Fund shares for an existing account by contacting
          your Morgan Stanley Dean Witter Financial Advisor, you may send a
          check directly to the Fund. To buy additional shares in this manner:

          o    Write a "letter of instruction" to the Fund specifying the
               name(s) on the account, the account number, the social security
               or tax identification number, the Class of shares you wish to
               purchase and the investment amount (which would include any
               applicable front-end sales charge). The letter must be signed by
               the account owner(s).

          o    Make out a check for the total amount payable to: Morgan Stanley
               Dean Witter Health Sciences Trust.

          o    Mail the letter and check to Morgan Stanley Dean Witter Trust FSB
               at P.O. Box 1040, Jersey City, NJ 07303.


10

<PAGE>



[GRAPHIC OMITTED]

       HOW TO EXCHANGE SHARES
- ------------------------------------

          Permissible Fund Exchanges. You may exchange shares of any Class of
          the Fund for the same Class of any other continuously offered
          Multi-Class Fund, or for shares of a No-Load Fund, a Money Market
          Fund, North American Government Income Trust or Short-Term U.S.
          Treasury Trust, without the imposition of an exchange fee. See the
          inside back cover of this Prospectus for each Morgan Stanley Dean
          Witter Fund's designation as a Multi-Class Fund, No-Load Fund or
          Money Market Fund. If a Morgan Stanley Dean Witter Fund is not
          listed, consult the inside back cover of that Fund's Prospectus for
          its designation. For purposes of exchanges, shares of FSC Funds
          (subject to a front-end sales charge) are treated as Class A shares
          of a Multi-Class Fund.


          Exchanges may be made after shares of the Fund acquired by purchase
          have been held for thirty days. There is no waiting period for
          exchanges of shares acquired by exchange or dividend reinvestment.
          The current Prospectus for each Fund describes its investment
          objective(s), policies and investment minimums, and should be read
          before investment. Since exchanges are available only into
          continuously offered Morgan Stanley Dean Witter Funds, exchanges are
          not available into any new Morgan Stanley Dean Witter Fund during its
          initial offering period, or when shares of a particular Morgan
          Stanley Dean Witter Fund are not being offered for purchase.



          Exchange Procedures. You can process an exchange by contacting your
          Morgan Stanley Dean Witter Financial Advisor or other authorized
          financial representative. Otherwise, you must forward an exchange
          privilege authorization form to the Fund's transfer agent -- Morgan
          Stanley Dean Witter Trust FSB -- and then write the transfer agent or
          call (800) 869-NEWS to place an exchange order. You can obtain an
          exchange privilege authorization form by contacting your Financial
          Advisor or other authorized financial representative or by calling
          (800) 869-NEWS. If you hold share certificates, no exchanges may be
          processed until we have received all applicable share certificates.


          An exchange to any Morgan Stanley Dean Witter Fund (except a Money
          Market Fund) is made on the basis of the next calculated net asset
          values of the Funds involved after the exchange instructions are
          accepted. When exchanging into a Money Market Fund, the Fund's shares
          are sold at their next calculated net asset value and the Money
          Market Fund's shares are purchased at their net asset value on the
          following business day.


          The Fund may terminate or revise the exchange privilege upon required
          notice. The check writing privilege is not available for Money Market
          Fund shares you acquire in an exchange.


          Telephone Exchanges. For your protection when calling Morgan Stanley
          Dean Witter Trust FSB, we will employ reasonable procedures to
          confirm that exchange instructions communicated over the telephone
          are genuine. These procedures may include


                                                                              11

<PAGE>



          requiring various forms of personal identification such as name,
          mailing address, social security or other tax identification number.
          Telephone instructions also may be recorded.


          Telephone instructions will be accepted if received by the Fund's
          transfer agent between 9:00 a.m. and 4:00 p.m. Eastern time, on any
          day the New York Stock Exchange is open for business. During periods
          of drastic economic or market changes, it is possible that the
          telephone exchange procedures may be difficult to implement, although
          this has not been the case with the Fund in the past.


          Margin Accounts. If you have pledged your Fund shares in a margin
          account, contact your Morgan Stanley Dean Witter Financial Advisor or
          other authorized financial representative regarding restrictions on
          the exchange of such shares.


          Tax Considerations of Exchanges. If you exchange shares of the Fund
          for shares of another Morgan Stanley Dean Witter Fund there are
          important tax considerations. For tax purposes, the exchange out of
          the Fund is considered a sale of Fund shares -- and the exchange into
          the other Fund is considered a purchase. As a result, you may realize
          a capital gain or loss.


          You should review the "Tax Consequences" section and consult your own
          tax professional about the tax consequences of an exchange.


          Frequent Exchanges. A pattern of frequent exchanges may result in the
          Fund limiting or prohibiting, at its discretion, additional purchases
          and/or exchanges. The Fund will notify you in advance of limiting
          your exchange privileges.


          CDSC Calculations on Exchanges. See the "Share Class Arrangements"
          section of this Prospectus for a further discussion of how applicable
          contingent deferred sales charges (CDSCs) are calculated for shares
          of one Morgan Stanley Dean Witter Fund that are exchanged for shares
          of another.


          For further information regarding exchange privileges, you should
          contact your Morgan Stanley Dean Witter Financial Advisor or call
          (800) 869-NEWS.


12

<PAGE>






[GRAPHIC OMITTED]

      HOW TO SELL SHARES
- -------------------------------
          You can sell some or all of your Fund shares at any time. If you sell
          Class A, Class B or Class C shares, your net sale proceeds are
          reduced by the amount of any applicable CDSC. Your shares will be
          sold at the next price calculated after we receive your order to sell
          as described below.

<TABLE>
<CAPTION>
OPTIONS               PROCEDURES
- --------------------- --------------------------------------------------------------------------------------------
<S>                   <C>
  Contact Your        To sell your shares, simply call your Morgan Stanley Dean Witter Financial Advisor or
  Financial Advisor   other authorized financial representative.
                      --------------------------------------------------------------------------------------------
 [GRAPHIC OMITTED]    Payment will be sent to the address to which the account is registered or deposited in
                      your brokerage account.
- --------------------- --------------------------------------------------------------------------------------------
  By Letter           You can also sell your shares by writing a "letter of instruction" that includes:
 [GRAPHIC OMITTED]    o  your account number;
                      o  the dollar amount or the number of shares you wish to sell;
                      o  the Class of shares you wish to sell; and
                      o  the signature of each owner as it appears on the account.
                      --------------------------------------------------------------------------------------------
                      If you are requesting payment to anyone other than the registered owner(s) or that
                      payment be sent to any address other than the address of the registered owner(s) or
                      pre-designated bank account, you will need a signature guarantee. You can obtain a
                      signature guarantee from an eligible guarantor acceptable to Morgan Stanley Dean
                      Witter Trust FSB. (You should contact Morgan Stanley Dean Witter Trust FSB at (800)
                      869-NEWS for a determination as to whether a particular institution is an eligible
                      guarantor.) A notary public cannot provide a signature guarantee. Additional
                      documentation may be required for shares held by a corporation, partnership, trustee
                      or executor.
                      --------------------------------------------------------------------------------------------
                      Mail the letter to Morgan Stanley Dean Witter Trust FSB at P.O. Box 983, Jersey City, NJ
                      07303. If you hold share certificates, you must return the certificates, along with the
                      letter and any required additional documentation.
                      --------------------------------------------------------------------------------------------
                      A check will be mailed to the name(s) and address in which the account is registered, or
                      otherwise according to your instructions.
                      --------------------------------------------------------------------------------------------
  Systematic          If your investment in all of the Morgan Stanley Dean Witter Family of Funds has a total
  Withdrawal Plan     market value of at least $10,000, you may elect to withdraw amounts of $25 or more,
                      or in any whole percentage of a Fund's balance (provided the amount is at least $25), on
[GRAPHIC OMITTED]     a monthly, quarterly, semi-annual or annual basis, from any Fund with a balance of at least
                      $1,000. Each time you add a Fund to the plan, you must meet the plan requirements.
                      --------------------------------------------------------------------------------------------
                      Amounts withdrawn are subject to any applicable CDSC. A CDSC may be waived under
                      certain circumstances. See the Class B waiver categories listed in the "Share Class
                      Arrangements" section of this Prospectus.
                      --------------------------------------------------------------------------------------------
                      To sign up for the Systematic Withdrawal Plan, contact your Morgan Stanley Dean
                      Witter Financial Advisor or call (800) 869-NEWS. You may terminate or suspend your
                      plan at any time. Please remember that withdrawals from the plan are sales of shares,
                      not Fund "distributions," and ultimately may exhaust your account balance. The Fund
                      may terminate or revise the plan at any time.
                      --------------------------------------------------------------------------------------------
</TABLE>

                                                                              13

<PAGE>



          Payment for Sold Shares. After we receive your complete instructions
          to sell as described above, a check will be mailed to you within
          seven days, although we will attempt to make payment within one
          business day. Payment may also be sent to your brokerage account.


          Payment may be postponed or the right to sell your shares suspended
          under unusual circumstances. If you request to sell shares that were
          recently purchased by check, payment of the sale proceeds may be
          delayed for the minimum time needed to verify that the check has been
          honored (not more than fifteen days from the time we receive the
          check).


          Tax Considerations. Normally, your sale of Fund shares is subject to
          federal and state income tax. You should review the "Tax
          Consequences" section of this Prospectus and consult your own tax
          professional about the tax consequences of a sale.


          Reinstatement Privilege. If you sell Fund shares and have not
          previously exercised the reinstatement privilege, you may, within 35
          days after the date of sale, invest any portion of the proceeds in
          the same Class of Fund shares at their net asset value and receive a
          pro rata credit for any CDSC paid in connection with the sale.


          Involuntary Sales. The Fund reserves the right, on sixty days'
          notice, to sell the shares of any shareholder (other than shares held
          in an IRA or 403(b) Custodial Account) whose shares, due to sales by
          the shareholder, have a value below $100, or in the case of an
          account opened through EasyInvest(SM), if after 12 months the
          shareholder has invested less than $1,000 in the account.


          However, before the Fund sells your shares in this manner, we will
          notify you and allow you sixty days to make an additional investment
          in an amount that will increase the value of your account to at least
          the required amount before the sale is processed. No CDSC will be
          imposed on any involuntary sale.


          Margin Accounts. If you have pledged your Fund shares in a margin
          account, contact your Morgan Stanley Dean Witter Financial Advisor or
          other authorized financial representative regarding restrictions on
          the sale of such shares.


14

<PAGE>




[GRAPHIC OMITTED]

      DISTRIBUTIONS
- ------------------------

[sidebar]
TARGETED DIVIDENDS(SM)
You may select to have your Fund distributions automatically invested in other
Classes of Fund shares or Classes of another Morgan Stanley Dean Witter Fund
that you own. Contact your Morgan Stanley Dean Witter Financial Advisor for
further information about this service.
[end sidebar]

                        The Fund passes substantially all of its earnings from
                        income and capital gains along to its investors as
                        "distributions." The Fund earns income from stocks and
                        interest from fixed-income investments. These amounts
                        are passed along to Fund shareholders as "income
                        dividend distributions." The Fund realizes capital gains
                        whenever it sells securities for a higher price than it
                        paid for them. These amounts may be passed along as
                        "capital gain distributions."


                        The Fund declares income dividends separately for each
                        Class. Distributions paid on Class A and Class D shares
                        usually will be higher than for Class B and Class C
                        because distribution fees that Class B and Class C pay
                        are higher. Normally, income dividends are distributed
                        to shareholders annually. Capital gains, if any, are
                        usually distributed in December. The Fund, however, may
                        retain and reinvest any long-term capital gains. The
                        Fund may at times make payments from sources other than
                        income or capital gains that represent a return of a
                        portion of your investment.


          Distributions are reinvested automatically in additional shares of
          the same Class and automatically credited to your account, unless you
          request in writing that all distributions be paid in cash. If you
          elect the cash option, the Fund will mail a check to you no later
          than seven business days after the distribution is declared. No
          interest will accrue on uncashed checks. If you wish to change how
          your distributions are paid, your request should be received by the
          Fund's transfer agent, Morgan Stanley Dean Witter Trust FSB, at least
          five business days prior to the record date of the distributions.




[GRAPHIC OMITTED]

       TAX CONSEQUENCES
- ----------------------------
          As with any investment, you should consider how your Fund investment
          will be taxed. The tax information in this Prospectus is provided as
          general information. You should consult your own tax professional
          about the tax consequences of an investment in the Fund.


          Unless your investment in the Fund is through a tax-deferred
          retirement account, such as a 401(k) plan or IRA, you need to be
          aware of the possible tax consequences when:
          o  The Fund makes distributions; and
          o  You sell Fund shares, including an exchange to another Morgan
             Stanley Dean Witter Fund.


          Taxes on Distributions. Your distributions are normally subject to
          federal and state income tax when they are paid, whether you take
          them in cash or reinvest them in Fund shares. A distribution also may
          be subject to local income tax. Any income dividend distributions and
          any short-term capital gain distributions are taxable to you as


                                                                              15

<PAGE>



          ordinary income. Any long-term capital gain distributions are taxable
          as long-term capital gains, no matter how long you have owned shares
          in the Fund.


          Every January, you will be sent a statement (IRS Form 1099-DIV)
          showing the taxable distributions paid to you in the previous year.
          The statement provides full information on your dividends and capital
          gains for tax purposes.


          Taxes on Sales. Your sale of Fund shares normally is subject to
          federal and state income tax and may result in a taxable gain or loss
          to you. A sale also may be subject to local income tax. Your exchange
          of Fund shares for shares of another Morgan Stanley Dean Witter Fund
          is treated for tax purposes like a sale of your original shares and a
          purchase of your new shares. Thus, the exchange may, like a sale,
          result in a taxable gain or loss to you and will give you a new tax
          basis for your new shares.


          When you open your Fund account, you should provide your social
          security or tax identification number on your investment application.
          By providing this information, you will avoid being subject to a
          federal backup withholding tax of 31% on taxable distributions and
          redemption proceeds. Any withheld amount would be sent to the IRS as
          an advance tax payment.




[GRAPHIC OMITTED]

       SHARE CLASS ARRANGEMENTS
- --------------------------------------
          The Fund offers several Classes of shares having different
          distribution arrangements designed to provide you with different
          purchase options according to your investment needs. Your Morgan
          Stanley Dean Witter Financial Advisor or other authorized financial
          representative can help you decide which Class may be appropriate for
          you.


          The general public is offered three Classes: Class A shares, Class B
          shares and Class C shares, which differ principally in terms of sales
          charges and ongoing expenses. A fourth Class, Class D shares, is
          offered only to a limited category of investors. Shares that you
          acquire through reinvested distributions will not be subject to any
          front-end sales charge or CDSC -- contingent deferred sales charge.
          Sales personnel may receive different compensation for selling each
          Class of shares. The sales charges applicable to each Class provide
          for the distribution financing of shares of that Class.


16

<PAGE>


         The chart below compares the sales charge and maximum annual 12b-1
         fee applicable to each Class:

<TABLE>
<CAPTION>
                                                                                                 MAXIMUM
CLASS    SALES CHARGE                                                                       ANNUAL 12B-1 FEE
<S>      <C>                                                                               <C>
  A      Maximum 5.25% initial sales charge reduced for purchase of $25,000 or more;
         shares sold without an initial sales charge are generally subject to a 1.0% CDSC
         during the first year                                                                    0.25%

  B      Maximum 5.0% CDSC during the first year decreasing to 0% after six years                 1.0%

  C      1.0% CDSC during the first year                                                          1.0%

  D      None                                                                                     None
</TABLE>


         CLASS A SHARES Class A shares are sold at net asset value plus an
         initial sales charge of up to 5.25%. The initial sales charge is
         reduced for purchases of $25,000 or more according to the schedule
         below. Investments of $1 million or more are not subject to an initial
         sales charge, but are generally subject to a contingent deferred sales
         charge, or CDSC, of 1.0% on sales made within one year after the last
         day of the month of purchase. The CDSC will be assessed in the same
         manner and with the same CDSC waivers as with Class B shares. Class A
         shares are also subject to a distribution (12b-1) fee of up to 0.25% of
         the average daily net assets of the Class.

         The offering price of Class A shares includes a sales charge (expressed
         as a percentage of the offering price) on a single transaction as shown
         in the following table:



[sidebar]
FRONT-END SALES CHARGE OR FSC An initial sales charge you pay when purchasing
Class A shares that is based on a percentage of the offering price. The
percentage declines based upon the dollar value of Class A shares you purchase.
We offer three ways to reduce your Class A sales charges -- the Combined
Purchase Privilege, Right of Accumulation and Letter of Intent.
[end sidebar]


<TABLE>
<CAPTION>
                                                  FRONT-END SALES CHARGE
                                                  ----------------------
                                           PERCENTAGE OF       APPROXIMATE PERCENTAGE
AMOUNT OF SINGLE TRANSACTION           PUBLIC OFFERING PRICE   OF NET AMOUNT INVESTED
<S>                                               <C>                     <C>
Less than $25,000                               5.25%                   5.54%
$25,000 but less than $50,000                   4.75%                   4.99%
$50,000 but less than $100,000                  4.00%                   4.17%
$100,000 but less than $250,000                 3.00%                   3.09%
$250,000 but less than $1 million               2.00%                   2.04%
$1 million and over                                0                       0
</TABLE>


                                                                              17

<PAGE>



          The reduced sales charge schedule is applicable to purchases of Class
          A shares in a single transaction by:

          o  A single account (including an individual, trust or fiduciary
             account).

          o  Family member accounts (limited to husband, wife and children under
             the age of 21).

          o  Pension, profit sharing or other employee benefit plans of
             companies and their affiliates.

          o  Tax-exempt organizations.

          o  Groups organized for a purpose other than to buy mutual fund
             shares.


          Combined Purchase Privilege. You also will have the benefit of
          reduced sales charges by combining purchases of Class A shares of the
          Fund in a single transaction with purchases of Class A shares of
          other Multi-Class Funds and shares of FSC Funds.


          Right of Accumulation. You also may benefit from a reduction of sales
          charges if the cumulative net asset value of Class A shares of the
          Fund purchased in a single transaction, together with shares of other
          Funds you currently own which were previously purchased at a price
          including a front-end sales charge (including shares acquired through
          reinvestment of distributions), amounts to $25,000 or more. Also, if
          you have a cumulative net asset value of all your Class A and Class D
          shares equal to at least $5 million (or $25 million for certain
          employee benefit plans), you are eligible to purchase Class D shares
          of any Fund subject to the Fund's minimum initial investment
          requirement.


          You must notify your Morgan Stanley Dean Witter Financial Advisor or
          other authorized financial representative (or Morgan Stanley Dean
          Witter Trust FSB if you purchase directly through the Fund), at the
          time a purchase order is placed, that the purchase qualifies for the
          reduced charge under the Right of Accumulation. Similar notification
          must be made in writing when an order is placed by mail. The reduced
          sales charge will not be granted if: (i) notification is not
          furnished at the time of the order; or (ii) a review of the records
          of Dean Witter Reynolds or other authorized dealer of Fund shares or
          the Fund's transfer agent does not confirm your represented holdings.



          Letter of Intent. The schedule of reduced sales charges for larger
          purchases also will be available to you if you enter into a written
          "letter of intent." A letter of intent provides for the purchase of
          Class A shares of the Fund or other Multi-Class Funds or shares of
          FSC Funds within a thirteen-month period. The initial purchase under
          a letter of intent must be at least 5% of the stated investment goal.
          To determine the applicable sales charge reduction, you may also
          include: (1) the cost of shares of other Morgan Stanley Dean Witter
          Funds which were previously purchased at a price including a
          front-end sales charge during the 90-day period prior to the
          distributor receiving the letter of intent, and (2) the cost of
          shares of other Funds you currently own acquired in exchange for
          shares of Funds purchased during that period at a price including a
          front-end sales charge. You can obtain a letter of intent by
          contacting your Morgan


18

<PAGE>



          Stanley Dean Witter Financial Advisor or other authorized financial
          representative, or by calling (800) 869-NEWS. If you do not achieve
          the stated investment goal within the thirteen-month period, you are
          required to pay the difference between the sales charges otherwise
          applicable and sales charges actually paid, which may be deducted
          from your investment.


          Other Sales Charge Waivers. In addition to investments of $1 million
          or more, your purchase of Class A shares is not subject to a
          front-end sales charge (or a CDSC upon sale) if your account
          qualifies under one of the following categories:

          o  A trust for which Morgan Stanley Dean Witter Trust FSB provides
             discretionary trustee services.

          o  Persons participating in a fee-based investment program (subject to
             all of its terms and conditions, including mandatory sale or
             transfer restrictions on termination) approved by the Fund's
             distributor pursuant to which they pay an asset-based fee for
             investment advisory, administrative and/or brokerage services.

          o  Employer-sponsored employee benefit plans, whether or not qualified
             under the Internal Revenue Code, for which Morgan Stanley Dean
             Witter Trust FSB serves as trustee or Dean Witter Reynolds'
             Retirement Plan Services serves as recordkeeper under a written
             Recordkeeping Services Agreement ("MSDW Eligible Plans") which have
             at least 200 eligible employees.

          o  An MSDW Eligible Plan whose Class B shares have converted to Class
             A shares, regardless of the plan's asset size or number of eligible
             employees.

          o  A client of a Morgan Stanley Dean Witter Financial Advisor who
             joined us from another investment firm within six months prior to
             the date of purchase of Fund shares, and you used the proceeds from
             the sale of shares of a proprietary mutual fund of that Financial
             Advisor's previous firm that imposed either a front-end or deferred
             sales charge to purchase Class A shares, provided that: (1) you
             sold the shares not more than 60 days prior to the purchase of Fund
             shares, and (2) the sale proceeds were maintained in the interim in
             cash or a money market fund.

          o  Current or retired Directors/Trustees of the Morgan Stanley Dean
             Witter Funds, such persons' spouses and children under the age of
             21, and trust accounts for which any of such persons is a
             beneficiary.

          o  Current or retired directors, officers and employees of Morgan
             Stanley Dean Witter & Co. and any of its subsidiaries, such
             persons' spouses and children under the age of 21, and trust
             accounts for which any of such persons is a beneficiary.


                                                                              19

<PAGE>



          CLASS B SHARES Class B shares are offered at net asset value with no
          initial sales charge but are subject to a contingent deferred sales
          charge, or CDSC, as set forth in the table below. For the purpose of
          calculating the CDSC, shares are deemed to have been purchased on
          the last day of the month during which they were purchased.

[sidebar]
CONTINGENT DEFERRED SALES CHARGE OR CDSC A fee you pay when you sell shares of
certain Morgan Stanley Dean Witter Funds purchased without an initial sales
charge. This fee declines the longer you hold your shares as set forth in the
table.
[end sidebar]

<TABLE>
<CAPTION>
                                      CDSC AS A PERCENTAGE OF
YEAR SINCE PURCHASE PAYMENT MADE          AMOUNT REDEEMED
<S>                                              <C>
  First                                          5.0%
  Second                                         4.0%
  Third                                          3.0%
  Fourth                                         2.0%
  Fifth                                          2.0%
  Sixth                                          1.0%
  Seventh and thereafter                         None
</TABLE>

          Each time you place an order to sell or exchange shares, shares with
          no CDSC will be sold or exchanged first, then shares with the lowest
          CDSC will be sold or exchanged next. For any shares subject to a
          CDSC, the CDSC will be assessed on an amount equal to the lesser of
          the current market value or the cost of the shares being sold.


          CDSC Waivers. A CDSC, if otherwise applicable, will be waived in the
          case of:

          o  Sales of shares held at the time you die or become disabled (within
             the definition in Section 72(m)(7) of the Internal Revenue Code
             which relates to the ability to engage in gainful employment), if
             the shares are: (i) registered either in your name (not a trust) or
             in the names of you and your spouse as joint tenants with right of
             survivorship; or (ii) held in a qualified corporate or
             self-employed retirement plan, IRA or 403(b) Custodial Account,
             provided in either case that the sale is requested within one year
             of your death or initial determination of disability.

          o  Sales in connection with the following retirement plan
             "distributions": (i) lump-sum or other distributions from a
             qualified corporate or self-employed retirement plan following
             retirement (or, in the case of a "key employee" of a "top heavy"
             plan, following attainment of age 59 1/2); (ii) distributions from
             an IRA or 403(b) Custodial Account following attainment of age
             59 1/2; or (iii) a tax-free return of an excess IRA contribution (a
             "distribution" does not include a direct transfer of IRA, 403(b)
             Custodial Account or retirement plan assets to a successor
             custodian or trustee).

          o  Sales of shares held for you as a participant in an MSDW Eligible
             Plan.

          o  Sales of shares in connection with the Systematic Withdrawal Plan
             of up to 12% annually of the value of each Fund from which plan
             sales are made. The percentage is determined on the date you
             establish the Systematic Withdrawal Plan and based on the next
             calculated share price. You may have this CDSC waiver applied in
             amounts up to 1% per month, 3% per quarter, 6% semi-annually or 12%
             annually. Shares with no CDSC will be sold first, followed by those
             with the lowest CDSC. As such, the waiver


20

<PAGE>



             benefit will be reduced by the amount of your shares that are
             not subject to a CDSC. If you suspend your participation in the
             plan, you may later resume plan payments without requiring a new
             determination of the account value for the 12% CDSC waiver.

          o  Sales of shares that (i) certain unit investment trusts purchased
             (on which a sales charge has been paid) or (ii) are attributable to
             reinvested distributions from, or the proceeds of, certain unit
             investment trusts.


          All waivers will be granted only following the Fund's distributor
          receiving confirmation of your entitlement. If you believe you are
          eligible for a CDSC waiver, please contact your Financial Advisor or
          call (800) 869-NEWS.


          Distribution Fee. Class B shares are subject to an annual
          distribution (12b-1) fee of 1.0% of the lesser of: (a) the average
          daily aggregate gross purchases by all shareholders of the Fund's
          Class B shares since the inception of the Fund (not including
          reinvestments of dividends or capital gains distributions), less the
          average daily aggregate net asset value of the Fund's Class B shares
          sold by all shareholders since the Fund's inception upon which a CDSC
          has been imposed or waived, or (b) the average daily net assets of
          Class B.


          Conversion Feature. After ten (10) years, Class B shares will convert
          automatically to Class A shares of the Fund with no initial sales
          charge. The ten year period runs from the last day of the month in
          which the shares were purchased, or in the case of Class B shares
          acquired through an exchange, from the last day of the month in which
          the original Class B shares were purchased; the shares will convert
          to Class A shares based on their relative net asset values in the
          month following the ten year period. At the same time, an equal
          proportion of Class B shares acquired through automatically
          reinvested distributions will convert to Class A shares on the same
          basis. (Class B shares held before May 1, 1997, however, will convert
          to Class A shares in May 2007.)


          In the case of Class B shares held in an MSDW Eligible Plan, the plan
          is treated as a single investor and all Class B shares will convert
          to Class A shares on the conversion date of the Class B shares of a
          Morgan Stanley Dean Witter Fund purchased by that plan.


          Currently, the Class B share conversion is not a taxable event; the
          conversion feature may be cancelled if it is deemed a taxable event
          in the future by the Internal Revenue Service.


          If you exchange your Class B shares for shares of a Money Market
          Fund, a No-Load Fund, North American Government Income Trust or
          Short-Term U.S. Treasury Trust, the holding period for conversion is
          frozen as of the last day of the month of the exchange and resumes on
          the last day of the month you exchange back into Class B shares.


                                                                              21

<PAGE>




          Exchanging Shares Subject to a CDSC. There are special considerations
          when you exchange Fund shares that are subject to a CDSC. When
          determining the length of time you held the shares and the
          corresponding CDSC rate, any period (starting at the end of the
          month) during which you held shares of a fund that does not charge a
          CDSC will not be counted. Thus, in effect the "holding period" for
          purposes of calculating the CDSC is frozen upon exchanging into a
          fund that does not charge a CDSC.


          For example, if you held Class B shares of the Fund in a regular
          account for one year, exchanged to Class B of another Morgan Stanley
          Dean Witter Multi-Class Fund for another year, then sold your shares,
          a CDSC rate of 4% would be imposed on the shares based on a two year
          holding period -- one year for each Fund. However, if you had
          exchanged the shares of the Fund for a Money Market Fund (which does
          not charge a CDSC) instead of the Multi-Class Fund, then sold your
          shares, a CDSC rate of 5% would be imposed on the shares based on a
          one year holding period. The one year in the Money Market Fund would
          not be counted. Nevertheless, if shares subject to a CDSC are
          exchanged for a Fund that does not charge a CDSC, you will receive a
          credit when you sell the shares equal to the distribution (12b-1)
          fees, if any, you paid on those shares while in that Fund up to the
          amount of any applicable CDSC.


          In addition, shares that are exchanged into or from a Morgan Stanley
          Dean Witter Fund subject to a higher CDSC rate will be subject to the
          higher rate, even if the shares are re-exchanged into a Fund with a
          lower CDSC rate.

          CLASS C SHARES Class C shares are sold at net asset value with no
          initial sales charge but are subject to a CDSC of 1.0% on sales made
          within one year after the last day of the month of purchase. The
          CDSC will be assessed in the same manner and with the same CDSC
          waivers as with Class B shares.

          Distribution Fee. Class C shares are subject to an annual
          distribution (12b-1) fee of up to 1.0% of the average daily net
          assets of that Class. The Class C shares' distribution fee may cause
          that Class to have higher expenses and pay lower dividends than Class
          A or Class D shares. Unlike Class B shares, Class C shares have no
          conversion feature and, accordingly, an investor that purchases Class
          C shares may be subject to distribution (12b-1) fees applicable to
          Class C shares for an indefinite period.

          CLASS D SHARES Class D shares are offered without any sales charge
          on purchases or sales and without any distribution (12b-1) fee.
          Class D shares are offered only to investors meeting an initial
          investment minimum of $5 million ($25 million for MSDW Eligible
          Plans) and the following investor categories:

          o  Investors participating in the Investment Manager's mutual fund
             asset allocation program (subject to all of its terms and
             conditions, including mandatory sale or transfer restrictions on
             termination) pursuant to which they pay an asset-based fee.


22

<PAGE>


          o  Persons participating in a fee-based investment program (subject to
             all of its terms and conditions, including mandatory sale or
             transfer restrictions on termination) approved by the Fund's
             distributor pursuant to which they pay an asset-based fee for
             investment advisory, administrative and/or brokerage services.

          o  Employee benefit plans maintained by Morgan Stanley Dean Witter &
             Co. or any of its subsidiaries for the benefit of certain employees
             of Morgan Stanley Dean Witter & Co. and its subsidiaries.

          o  Certain unit investment trusts sponsored by Dean Witter Reynolds.


          o  Certain other open-end investment companies whose shares are
             distributed by the Fund's distributor.

          o  Investors who were shareholders of the Dean Witter Retirement
             Series on September 11, 1998 for additional purchases for their
             former Dean Witter Retirement Series accounts.


          Meeting Class D Eligibility Minimums. To meet the $5 million ($25
          million for MSDW Eligible Plans) initial investment to qualify to
          purchase Class D shares you may combine: (1) purchases in a single
          transaction of Class D shares of the Fund and other Morgan Stanley
          Dean Witter Multi-Class Funds and/or (2) previous purchases of Class
          A and Class D shares of Multi-Class Funds and shares of FSC Funds you
          currently own, along with shares of Morgan Stanley Dean Witter Funds
          you currently own that you acquired in exchange for those shares.

          NO SALES CHARGES FOR REINVESTED CASH DISTRIBUTIONS If you receive a
          cash payment representing an income dividend or capital gain and you
          reinvest that amount in the applicable Class of shares by returning
          the check within 30 days of the payment date, the purchased shares
          would not be subject to an initial sales charge or CDSC.

          PLAN OF DISTRIBUTION (RULE 12b-1 FEES) The Fund has adopted a Plan
          of Distribution in accordance with Rule 12b-1 under the Investment
          Company Act of 1940 with respect to the distribution of Class A,
          Class B and Class C shares. The Plan allows the Fund to pay
          distribution fees for the sale and distribution of these shares. It
          also allows the Fund to pay for services to shareholders of Class A,
          Class B and Class C shares. Because these fees are paid out of the
          Fund's assets on an ongoing basis, over time these fees will
          increase the cost of your investment in these Classes and may cost
          you more than paying other types of sales charges.


                                                                              23

<PAGE>


FINANCIAL HIGHLIGHTS


The financial highlights table is intended to help you understand the Fund's
financial performance for the past 5 fiscal years of the Fund. Certain
information reflects financial results for a single Fund share throughout each
year. The total returns in the table represent the rate an investor would have
earned or lost on an investment in the Fund (assuming reinvestment of all
dividends and distributions).

This information has been audited by PricewaterhouseCoopers LLP, independent
accountants, whose report, along with the Fund's financial statements, is
included in the annual report, which is available upon request.


<TABLE>
<CAPTION>
                                                                        FOR THE PERIOD
                                                                        JULY 28, 1997*
                                                                           THROUGH
FOR THE YEAR ENDED JULY 31,                    1999           1998      JULY 31, 1997
- ---------------------------                    ----           ----      -------------
<S>                                          <C>             <C>         <C>
 CLASS A SHARES++
 SELECTED PER SHARE DATA:
 Net asset value, beginning of period         $15.31         $15.10       $15.03
- --------------------------------------------  -------        -------      ---------
 Income (loss) from investment operations:
  Net investment loss                          (0.10)         (0.18)         --
  Net realized and unrealized gain              1.59           1.55         0.07
                                              -------        -------      ---------
 Total income from investment operations        1.49           1.37         0.07
- --------------------------------------------  -------        -------      ---------
 Less distributions from net realized gain     (3.41)         (1.16)         --
                                              -------        -------      ---------
 Net asset value, end of period               $13.39         $15.31       $15.10
- --------------------------------------------  -------        -------      ---------
 TOTAL RETURN+                                 10.03%          9.94%        0.47%(1)
- --------------------------------------------  -------        -------      ---------
 RATIOS TO AVERAGE NET ASSETS:
 Expenses                                       1.47 %(3)      1.51 %       1.57%(2)
 Net investment loss                           (0.74)%(3)     (1.06)%      (0.55)%(2)
- -------------------------------------------- --------        -------      ---------
 SUPPLEMENTAL DATA:
 Net assets, end of period, in thousands      $  707         $  260       $   10
 Portfolio turnover rate                        148%           139%          85%
</TABLE>



*   The date shares were first issued.

++  The per share amounts were computed using an average number of shares
    outstanding during the period.

+   Does not reflect the deduction of sales charge. Calculated based on the net
    asset value as of the last business day of the period.

(1) Not annualized.

(2) Annualized.

(3) Reflects overall Fund ratios for investment income and non-class specific
    expenses.


24

<PAGE>





<TABLE>
<CAPTION>
FOR THE YEAR ENDED JULY 31,                     1999++          1998++         1997*         1996          1995
- ---------------------------                     ------          ------         -----         ----          ----
<S>                                          <C>                <C>           <C>           <C>           <C>
 CLASS B SHARES
 SELECTED PER SHARE DATA:
 Net asset value, beginning of period          $15.22            $15.10        $14.97        $12.88        $ 9.32
- --------------------------------------------  ---------         --------      --------      --------      --------
 Income (loss) from investment operations:
  Net investment loss                           (0.21)            (0.31)        (0.31)        (0.26)        (0.24)
  Net realized and unrealized gain               1.57              1.59          1.39          3.44          3.80
                                              ---------         --------      --------      --------      --------
 Total income from investment operations         1.36              1.28          1.08          3.18          3.56
- --------------------------------------------  ---------         --------      --------      --------      --------
 Less distributions from net realized gain      (3.41)            (1.16)        (0.95)        (1.09)           --
- --------------------------------------------  ---------         --------      --------      --------      --------
 Net asset value, end of period                $13.17            $15.22        $15.10        $14.97        $12.88
- --------------------------------------------  ---------         --------      --------      --------      --------
 TOTAL RETURN+                                   9.12%             9.33%         7.55%        24.84%        38.20%
 RATIOS TO AVERAGE NET ASSETS:
 Expenses                                      2.27 %(1)           2.26%         2.25%         2.20%         2.30%
 Net investment loss                            (1.54)%(1)        (1.87)%       (2.08)%       (2.03)%       (2.05)%
- -------------------------------------------- ----------         --------      --------      --------      --------
 SUPPLEMENTAL DATA:
 Net assets, end of period, in thousands      $295,446          $355,416      $422,667      $442,876      $273,735
 Portfolio turnover rate                          148%              139%           85%           63%          145%
</TABLE>



*   Prior to July 28, 1997, the Fund issued one class of shares. All shares of
    the Fund held prior to that date have been designated Class B shares.

++  The per share amounts were computed using an average number of shares
    outstanding during the period.

+   Does not reflect the deduction of sales charge. Calculated based on the net
    asset value of the last business day of the period.

(1) Reflects overall Fund ratios for investment income and non-class specific
    expenses.



                                                                              25


<PAGE>




<TABLE>
<CAPTION>
                                                                            FOR THE PERIOD
                                                                            JULY 28, 1997*
                                                                               THROUGH
FOR THE YEAR ENDED JULY 31,                      1999             1998      JULY 31, 1997
- ---------------------------                      ----             ----      -------------
<S>                                            <C>               <C>           <C>
 CLASS C SHARES++
 SELECTED PER SHARE DATA:
 Net asset value, beginning of period            $15.23           $15.10        $15.03
- --------------------------------------------    -------          -------        ---------
 Income (loss) from investment operations:
  Net investment loss                            (0.21)           (0.29)           --
  Net realized and unrealized gain                1.57             1.58           0.07
                                                -------          -------        ---------
 Total income from investment operations          1.36             1.29           0.07
- --------------------------------------------    -------          -------        ---------
 Less distributions from net realized gain       (3.41)           (1.16)           --
                                                -------          -------        ---------
 Net asset value, end of period                 $13.18           $15.23         $15.10
- --------------------------------------------    -------          -------        ---------
 TOTAL RETURN+                                    9.13%            9.40%          0.47%(1)
- --------------------------------------------    -------          -------        ---------
 RATIOS TO AVERAGE NET ASSETS:
 Expenses                                         2.27%(3)         2.27%          2.31%(2)
 Net investment loss                             (1.54)%(3)       (1.78)%        (1.28)%(2)
- --------------------------------------------    ---------        -------        ---------
 SUPPLEMENTAL DATA:
 Net assets, end of period, in thousands        $1,562           $  485         $   20
 Portfolio turnover rate                          148%             139%            85%
</TABLE>



 *  The date shares were first issued.

++  The per share amounts were computed using an average number of shares
    outstanding during the period.

+   Does not reflect the deduction of sales charge. Calculated based on the net
    asset value of the last business day of the period.

(1) Not annualized.

(2) Annualized.

(3) Reflects overall Fund ratios for investment income and non-class specific
    expenses.


26

<PAGE>




<TABLE>
<CAPTION>
                                                                               FOR THE PERIOD
                                                                               JULY 28, 1997*
                                                                                  THROUGH
FOR THE YEAR ENDED JULY 31,                        1999            1998        JULY 31, 1997
- ---------------------------                        ----            ----        -------------
<S>                                            <C>                <C>           <C>
 CLASS D SHARES++
 SELECTED PER SHARE DATA:
 Net asset value, beginning of period           $15.35            $15.10         $15.03
- --------------------------------------------    -------           -------        ---------
 Income (loss) from investment operations:
  Net investment loss                            (0.09)            (0.14)           --
  Net realized and unrealized gain                1.61              1.55           0.07
                                                -------           -------        ---------
 Total income from investment operations          1.52              1.41           0.07
- --------------------------------------------    -------           -------        ---------
 Less distributions from net realized gain       (3.41)            (1.16)           --
                                                -------           -------        ---------
 Net asset value, end of period                 $13.46            $15.35         $15.10
- --------------------------------------------    -------           -------        ---------
 TOTAL RETURN+                                   10.22%            10.22%          0.47%(1)
- --------------------------------------------    -------           -------        ---------
 RATIOS TO AVERAGE NET ASSETS:
- --------------------------------------------
 Expenses                                         1.27%(3)          1.26%          1.31%(2)
 Net investment loss                            ( 0.54)%(3)        (0.79)%        (0.29)%(2)
- --------------------------------------------    ---------         -------        ---------
 SUPPLEMENTAL DATA:
 Net assets, end of period, in thousands        $1,485            $1,244         $   10
 Portfolio turnover rate                           148%              139%            85%
</TABLE>

*   The date shares were first issued.

++  The per share amounts were computed using an average number of shares
    outstanding during the period.

+   Calculated based on the net asset value of the last business day of the
    period.

(1) Not annualized.

(2) Annualized.

(3) Reflects overall Fund ratios for investment income and non-class specific
    expenses.

                                                                              27


<PAGE>



MORGAN STANLEY DEAN WITTER
FAMILY OF FUNDS


            The Morgan Stanley Dean Witter Family of Funds offers investors a
            wide range of investment choices. Come on in and meet the family!
- --------------------------------------------------------------------------------


GROWTH FUNDS
- ------------
GROWTH FUNDS
Aggressive Equity Fund
American Opportunities Fund
Capital Growth Securities
Developing Growth Securities
Growth Fund
Market Leader Trust
Mid-Cap Equity Trust
Small Cap Growth Fund
Special Value Fund

THEME FUNDS
Financial Services Trust
Health Sciences Trust
Information Fund
Natural Resource Development Securities
Precious Metals and Minerals Trust

GLOBAL/INTERNATIONAL FUNDS
Competitive Edge Fund - "Best Ideas"  Portfolio
European Growth Fund
Fund of Funds - International Portfolio
International Fund
International SmallCap Fund
Japan Fund
Latin American Growth Fund
Pacific Growth Fund

- --------------------------------------------------------------------------------

GROWTH & INCOME FUNDS
- ---------------------
Balanced Growth Fund
Balanced Income Fund
Convertible Securities Trust
Dividend Growth Securities
Equity Fund
Fund of Funds - Domestic Portfolio
Income Builder Fund
Mid-Cap Dividend Growth Securities
S&P 500 Index Fund
S&P 500 Select Fund
Strategist Fund
Total Market Index Fund
Total Return Trust
Value Fund
Value/Added Market Series/Equity Portfolio

THEME FUNDS
Global Utilities Fund
Real Estate Fund
Utilities Fund

GLOBAL FUNDS
Global Dividend Growth Securities

- --------------------------------------------------------------------------------

INCOME FUNDS
- ------------
GOVERNMENT INCOME FUNDS
Federal Securities Trust
Short-Term U.S. Treasury Trust
U.S. Government Securities Trust

DIVERSIFIED INCOME FUNDS
Diversified Income Trust

CORPORATE INCOME FUNDS
High Yield Securities
Intermediate Income Securities
Short-Term Bond Fund(NL)

GLOBAL INCOME FUNDS
North American Government Income Trust
World Wide Income Trust

TAX-FREE INCOME FUNDS
California Tax-Free Income Fund
Hawaii Municipal Trust(FSC)
Limited Term Municipal Trust(NL)
Multi-State Municipal Series Trust(FSC)
New York Tax-Free Income Fund
Tax-Exempt Securities Trust

- --------------------------------------------------------------------------------

MONEY MARKET FUNDS
- ------------------
TAXABLE MONEY MARKET FUNDS
Liquid Asset Fund(MM)
U.S. Government Money Market Trust(MM)

TAX-FREE MONEY MARKET FUNDS
California Tax-Free Daily Income Trust(MM)
New York Municipal Money Market Trust(MM)
Tax-Free Daily Income Trust(MM)

There may be Funds created after this Prospectus was published. Please consult
the inside back cover of a new Fund's prospectus for its designation, e.g.,
Multi-Class Fund or Money Market Fund.


Unless otherwise noted, each listed Morgan Stanley Dean Witter Fund, except for
North American Government Income Trust and Short-Term U.S. Treasury Trust, is a
Multi-Class Fund. A Multi-Class Fund is a mutual fund offering multiple Classes
of shares. The other types of Funds are: NL -- No-Load (Mutual) Fund; MM --
Money Market Fund; FSC -- A mutual fund sold with a front-end sales charge and
a distribution (12b-1) fee.


<PAGE>



                                          PROSPECTUS - SEPTEMBER 27, 1999

Additional information about the Fund's investments is available in the Fund's
Annual and Semi-Annual Reports to Shareholders. In the Fund's Annual Report, you
will find a discussion of the market conditions and investment strategies that
significantly affected the Fund's performance during its last fiscal year. The
Fund's Statement of Additional Information also provides additional information
about the Fund. The Statement of Additional Information is incorporated herein
by reference (legally is part of this Prospectus). For a free copy of any of
these documents, to request other information about the Fund, or to make
shareholder inquiries, please call:

                                (800) 869-NEWS

You also may obtain information about the Fund by calling your Morgan Stanley
Dean Witter Financial Advisor or by visiting our Internet site at:


                         www.msdw.com/individual/funds



Information about the Fund (including the Statement of Additional Information)
can be viewed and copied at the Securities and Exchange Commission's Public
Reference Room in Washington, DC. Information about the Reference Room's
operations may be obtained by calling the SEC at (800) SEC-0330. Reports and
other information about the Fund are available on the SEC's Internet site
(www.sec.gov), and copies of this information may be obtained, upon payment of
a duplicating fee, by writing the Public Reference Section of the SEC,
Washington, DC 20549-6009.

TICKER SYMBOLS:

  Class A:            HCRAX
- --------------
  Class B :           HCRBX
- --------------
  Class C:            HCRCX
- --------------
  Class D:            HCRDX
- --------------

(THE FUND'S INVESTMENT COMPANY ACT FILE NO. IS 811-6683)




Morgan Stanley Dean Witter


           HEALTH SCIENCES TRUST






[GRAPHIC OMITTED]






            A MUTUAL FUND THAT SEEKS CAPITAL APPRECIATION






<PAGE>

STATEMENT OF ADDITIONAL INFORMATION
                                        MORGAN STANLEY DEAN WITTER
                                        HEALTH SCIENCES TRUST
SEPTEMBER 27, 1999
- --------------------------------------------------------------------------------
     This Statement of Additional Information is not a Prospectus. The
Prospectus (dated September 27, 1999) for the Morgan Stanley Dean Witter Health
Sciences Trust may be obtained without charge from the Fund at its address or
telephone number listed below or from Dean Witter Reynolds at any of its branch
offices.




Morgan Stanley Dean Witter Health Sciences Trust
Two World Trade Center
New York, New York 10048
(800) 869-NEWS
<PAGE>

TABLE OF CONTENTS
- --------------------------------------------------------------------------------


<TABLE>
<S>                                                                                   <C>
I.    Fund History ..................................................................  4
II.   Description of the Fund and Its Investments and Risks .........................  4
        A.  Classification ..........................................................  4
        B.  Investment Strategies and Risks .........................................  4
        C.  Fund Policies/Investment Restrictions ................................... 14
III.  Management of the Fund ........................................................ 15
        A.  Board of Trustees ....................................................... 15
        B.  Management Information .................................................. 16
        C.  Compensation ............................................................ 20
IV.   Control Persons and Principal Holders of Securities ........................... 22
V.    Investment Management and Other Services ...................................... 22
        A.  Investment Manager ...................................................... 22
        B.  Principal Underwriter ................................................... 23
        C.  Services Provided by the Investment Manager and Fund Expenses Paid by
             Third Parties .......................................................... 23
        D.  Dealer Reallowances ..................................................... 24
        E.  Rule 12b-1 Plan ......................................................... 24
        F.  Other Service Providers ................................................. 28
VI.   Brokerage Allocation and Other Practices ...................................... 29
        A.  Brokerage Transactions .................................................. 29
        B.  Commissions ............................................................. 29
        C.  Brokerage Selection ..................................................... 30
        D.  Directed Brokerage ...................................................... 31
        E.  Regular Broker-Dealers .................................................. 31
VII.  Capital Stock and Other Securities ............................................ 31
VIII. Purchase, Redemption and Pricing of Shares .................................... 32
        A.  Purchase/Redemption of Shares............................................ 32
        B.  Offering Price .......................................................... 32
IX.   Taxation of the Fund and Shareholders ......................................... 33
X.    Underwriters .................................................................. 35
XI.   Calculation of Performance Data ............................................... 35
XII.  Financial Statements .......................................................... 36
</TABLE>


                                       2
<PAGE>

                      GLOSSARY OF SELECTED DEFINED TERMS

     The terms defined in this glossary are frequently used in this Statement
of Additional Information (other terms used occasionally are defined in the
text of the document).

     "Custodian" -- The Bank of New York.

     "Dean Witter Reynolds" -- Dean Witter Reynolds Inc., a wholly-owned
broker-dealer subsidiary of MSDW.

     "Distributor" -- Morgan Stanley Dean Witter Distributors Inc., a
wholly-owned broker-dealer subsidiary of MSDW.

     "Financial Advisors" -- Morgan Stanley Dean Witter authorized financial
services representatives.

     "Fund" -- Morgan Stanley Dean Witter Health Sciences Trust, a registered
open-end investment company.

     "Investment Manager" -- Morgan Stanley Dean Witter Advisors Inc., a
wholly-owned investment advisor subsidiary of MSDW.

     "Independent Trustees" -- Trustees who are not "interested persons" (as
defined by the Investment Company Act) of the Fund.

     "Morgan Stanley & Co." -- Morgan Stanley & Co. Incorporated, a
wholly-owned broker-dealer subsidiary of MSDW.

     "Morgan Stanley Dean Witter Funds" -- Registered investment companies (i)
for which the Investment Manager serves as the investment advisor and (ii) that
hold themselves out to investors as related companies for investment and
investor services.

     "MSDW" -- Morgan Stanley Dean Witter & Co., a preeminent global financial
services firm.

   "MSDW Services Company" -- Morgan Stanley Dean Witter Services Company
Inc., a wholly-owned fund services subsidiary of the Investment Manager.

     "Transfer Agent" -- Morgan Stanley Dean Witter Trust FSB, a wholly-owned
transfer agent subsidiary of MSDW.

     "Trustees" -- The Board of Trustees of the Fund.

                                       3
<PAGE>

I. FUND HISTORY
- --------------------------------------------------------------------------------
     The Fund was organized as a Massachusetts business trust, under a
Declaration of Trust, on May 26, 1992, with the name Dean Witter Health
Sciences Trust. Effective June 22, 1998, the Fund's name was changed to Morgan
Stanley Dean Witter Health Sciences Trust.

II. DESCRIPTION OF THE FUND AND ITS INVESTMENTS AND RISKS
- --------------------------------------------------------------------------------
A. CLASSIFICATION

     The Fund is an open-end management investment company whose investment
objective is to seek capital appreciation.

     The Fund is a "non-diversified" mutual fund and, as such, its investments
are not required to meet certain diversification requirements under federal
securities law. Compared with "diversified" funds, the Fund may invest a
greater percentage of its assets in the securities of an individual corporation
or governmental entity. Thus, the Fund's assets may be concentrated in fewer
securities than other funds. A decline in the value of those investments would
cause the Fund's overall value to decline to a greater degree. The Fund's
investments, however, are currently diversified and may remain diversified in
the future.

B. INVESTMENT STRATEGIES AND RISKS

     The following discussion of the Fund's investment strategies and risks
should be read with the sections of the Fund's Prospectus titled "Principal
Investment Strategies," "Principal Risks," "Additional Investment Strategy
Information," and "Additional Risk Information."

     FORWARD FOREIGN CURRENCY EXCHANGE CONTRACTS. The Fund may enter into
forward foreign currency exchange contracts ("forward contracts") as a hedge
against fluctuations in future foreign exchange rates. The Fund may conduct its
foreign currency exchange transactions either on a spot (i.e., cash) basis at
the spot rate prevailing in the foreign currency exchange market, or through
entering into forward contracts to purchase or sell foreign currencies. A
forward contract involves an obligation to purchase or sell a specific currency
at a future date, which may be any fixed number of days from the date of the
contract agreed upon by the parties, at a price set at the time of the
contract. These contracts are traded in the interbank market conducted directly
between currency traders (usually large, commercial and investment banks) and
their customers. Forward contracts only will be entered into with United States
banks and their foreign branches, insurance companies and other dealers or
foreign banks whose assets total $1 billion or more. A forward contract
generally has no deposit requirement, and no commissions are charged at any
stage for trades.

     The Fund may enter into forward contracts under various circumstances. The
typical use of a forward contract is to "lock in" the price of a security in
U.S. dollars or some other foreign currency which the Fund is holding in its
portfolio. By entering into a forward contract for the purchase or sale, for a
fixed amount of dollars or other currency, of the amount of foreign currency
involved in the underlying security transactions, the Fund may be able to
protect itself against a possible loss resulting from an adverse change in the
relationship between the U.S. dollar or other currency which is being used for
the security purchase and the foreign currency in which the security is
denominated during the period between the date on which the security is
purchased or sold and the date on which payment is made or received.

     The Investment Manager also may from time to time utilize forward
contracts for other purposes. For example, they may be used to hedge a foreign
security held in the portfolio or a security which pays out principal tied to
an exchange rate between the U.S. dollar and a foreign currency, against a
decline in value of the applicable foreign currency. They also may be used to
lock in the current exchange rate of the currency in which those securities
anticipated to be purchased are denominated. At times, the Fund may enter into
"cross-currency" hedging transactions involving currencies other than those in
which securities are held or proposed to be purchased are denominated.


                                       4
<PAGE>

     The Fund will not enter into forward currency contracts or maintain a net
exposure to these contracts where the consummation of the contracts would
obligate the Fund to deliver an amount of foreign currency in excess of the
value of the Fund's portfolio securities.

     Although the Fund values its assets daily in terms of U.S. dollars, it
does not intend to convert its holdings of foreign currencies into U.S. dollars
on a daily basis. It will, however, do so from time to time, and investors
should be aware of the costs of currency conversion. Although foreign exchange
dealers do not charge a fee for conversion, they do realize a profit based on
the spread between the prices at which they are buying and selling various
currencies. Thus, a dealer may offer to sell a foreign currency to the Fund at
one rate, while offering a lesser rate of exchange should the Fund desire to
resell that currency to the dealer.

     The Fund may be limited in its ability to enter into hedging transactions
involving forward contracts by the Internal Revenue Code requirements relating
to qualification as a regulated investment company.

     Forward currency contracts may limit gains on portfolio securities that
could otherwise be realized had they not been utilized and could result in
losses. The contracts also may increase the Fund's volatility and may involve a
significant amount of risk relative to the investment of cash.

     OPTIONS AND FUTURES TRANSACTIONS. The Fund may engage in transactions in
listed and OTC options. Listed options are issued or guaranteed by the exchange
on which they are traded or by a clearing corporation such as the Options
Clearing Corporation ("OCC"). Ownership of a listed call option gives the Fund
the right to buy from the OCC (in the U.S.) or other clearing corporation or
exchange, the underlying security or currency covered by the option at the
stated exercise price (the price per unit of the underlying security) by filing
an exercise notice prior to the expiration date of the option. The writer
(seller) of the option would then have the obligation to sell to the OCC (in
the U.S.) or other clearing corporation or exchange, the underlying security or
currency at that exercise price prior to the expiration date of the option,
regardless of its then current market price. Ownership of a listed put option
would give the Fund the right to sell the underlying security or currency to
the OCC (in the U.S.) or other clearing corporation or exchange, at the stated
exercise price. Upon notice of exercise of the put option, the writer of the
put would have the obligation to purchase the underlying security or currency
from the OCC (in the U.S.) or other clearing corporation or exchange, at the
exercise price.

     Covered Call Writing. The Fund is permitted to write covered call options
on portfolio securities and on the U.S. dollar and foreign currencies in which
they are denominated, without limit.

     The Fund will receive from the purchaser, in return for a call it has
written, a "premium;" i.e., the price of the option. Receipt of these premiums
may better enable the Fund to earn a higher level of current income than it
would earn from holding the underlying securities (or currencies) alone.
Moreover, the premium received will offset a portion of the potential loss
incurred by the Fund if the securities (or currencies) underlying the option
decline in value.

     The Fund may be required, at any time during the option period, to deliver
the underlying security (or currency) against payment of the exercise price on
any calls it has written. This obligation is terminated upon the expiration of
the option period or at such earlier time when the writer effects a closing
purchase transaction. A closing purchase transaction is accomplished by
purchasing an option of the same series as the option previously written.
However, once the Fund has been assigned an exercise notice, the Fund will be
unable to effect a closing purchase transaction.

     A call option is "covered" if the Fund owns the underlying security
subject to the option or has an absolute and immediate right to acquire that
security without additional cash consideration (or for additional consideration
(in cash, Treasury bills or other liquid portfolio securities) held in a
segregated account on the Fund's books) upon conversion or exchange of other
securities held in its portfolio. A call option is also covered if the Fund
holds a call on the same security as the call written where the exercise price
of the call held is (i) equal to or less than the exercise price of the call
written or (ii) greater than the exercise price of the call written if the
difference is maintained by the Fund in cash, Treasury bills or other liquid
portfolio securities in a segregated account on the Fund's books.


                                       5
<PAGE>

     Options written by the Fund normally have expiration dates of from up to
eighteen months from the date written. The exercise price of a call option may
be below, equal to or above the current market value of the underlying security
at the time the option is written.

     Covered Put Writing. A writer of a covered put option incurs an obligation
to buy the security underlying the option from the purchaser of the put, at the
option's exercise price at any time during the option period, at the
purchaser's election. Through the writing of a put option, the Fund would
receive income from the premium paid by purchasers. The potential gain on a
covered put option is limited to the premium received on the option (less the
commissions paid on the transaction). During the option period, the Fund may be
required, at any time, to make payment of the exercise price against delivery
of the underlying security (or currency). The aggregate value of the
obligations underlying puts may not exceed 50% of the Fund's assets. A put
option is "covered" if the Fund maintains cash, Treasury bills or other liquid
portfolio securities with a value equal to the exercise price in a segregated
account on the Fund's books, or holds a put on the same security as the put
written where the exercise price of the put held is equal to or greater than
the exercise price of the put written. The operation of and limitations on
covered put options in other respects are substantially identical to those of
call options.

     Purchasing Call and Put Options. The Fund may purchase listed and OTC call
and put options in amounts equaling up to 5% of its total assets. The purchase
of a call option would enable the Fund, in return for the premium paid to lock
in a purchase price for a security or currency during the term of the option.
The purchase of a put option would enable the Fund, in return for a premium
paid, to lock in a price at which it may sell a security or currency during the
term of the option.

     Options on Foreign Currencies. The Fund may purchase and write options on
foreign currencies for purposes similar to those involved with investing in
forward foreign currency exchange contracts.

     OTC Options. OTC options are purchased from or sold (written) to dealers
or financial institutions which have entered into direct agreements with the
Fund. With OTC options, such variables as expiration date, exercise price and
premium will be agreed upon between the Fund and the transacting dealer,
without the intermediation of a third party such as the OCC. The Fund will
engage in OTC option transactions only with member banks of the Federal Reserve
Bank System or primary dealers in U.S. Government securities or with affiliates
of such banks or dealers.

     Risks of Options Transactions. The successful use of options depends on
the ability of the Investment Manager to forecast correctly interest rates,
currency exchange rates and/or market movements. If the market value of the
portfolio securities (or the currencies in which they are denominated) upon
which call options have been written increases, the Fund may receive a lower
total return from the portion of its portfolio upon which calls have been
written than it would have had such calls not been written. During the option
period, the covered call writer has, in return for the premium on the option,
given up the opportunity for capital appreciation above the exercise price
should the market price of the underlying security (or the value of its
denominated currency) increase, but has retained the risk of loss should the
price of the underlying security (or the value of its denominated currency)
decline. The covered put writer also retains the risk of loss should the market
value of the underlying security decline below the exercise price of the option
less the premium received on the sale of the option. In both cases, the writer
has no control over the time when it may be required to fulfill its obligation
as a writer of the option. Prior to exercise or expiration, an option position
can only be terminated by entering into a closing purchase or sale transaction.
Once an option writer has received an exercise notice, it cannot effect a
closing purchase transaction in order to terminate its obligation under the
option and must deliver or receive the underlying securities at the exercise
price.

     The Fund's ability to close out its position as a writer of an option is
dependent upon the existence of a liquid secondary market on option exchanges.
There is no assurance that such a market will exist, particularly in the case
of OTC options.

     In the event of the bankruptcy of a broker through which the Fund engages
in transactions in options, the Fund could experience delays and/or losses in
liquidating open positions purchased or sold through the broker and/or incur a
loss of all or part of its margin deposits with the broker. In the case of


                                       6
<PAGE>

OTC options, if the transacting dealer fails to make or take delivery of the
securities underlying an option it has written, in accordance with the terms of
that option, due to insolvency or otherwise, the Fund would lose the premium
paid for the option as well as any anticipated benefit of the transaction.

     Each of the exchanges has established limitations governing the maximum
number of call or put options on the same underlying security which may be
written by a single investor, whether acting alone or in concert with others
(regardless of whether such options are written on the same or different
exchanges or are held or written on one or more accounts or through one or more
brokers). An exchange may order the liquidation of positions found to be in
violation of these limits and it may impose other sanctions or restrictions.
These position limits may restrict the number of listed options which the Fund
may write.

     The hours of trading for options may not conform to the hours during which
the underlying securities are traded. To the extent that the option markets
close before the markets for the underlying securities, significant price and
rate movements can take place in the underlying markets that cannot be
reflected in the option markets.

     The markets in foreign currency options are relatively new and the Fund's
ability to establish and close out positions on such options is subject to the
maintenance of a liquid secondary market. There can be no assurance that a
liquid secondary market will exist for a particular option at any specific
time.

     The value of a foreign currency option depends upon the value of the
underlying currency relative to the U.S. dollar. As a result, the price of the
option position may vary with changes in the value of either or both currencies
and have no relationship to the investment merits of a foreign security.
Because foreign currency transactions occurring in the interbank market involve
substantially larger amounts than those that may be involved in the use of
foreign currency options, investors may be disadvantaged by having to deal in
an odd lot market (generally consisting of transactions of less than $1
million) for the underlying foreign currencies at prices that are less
favorable than for round lots.

     There is no systematic reporting of last sale information for foreign
currencies or any regulatory requirement that quotations available through
dealers or other market sources be firm or revised on a timely basis. Quotation
information available is generally representative of very large transactions in
the interbank market and thus may not reflect relatively smaller transactions
(i.e., less than $1 million) where rates may be less favorable. The interbank
market in foreign currencies is a global, around-the-clock market. To the
extent that the U.S. options markets are closed while the markets for the
underlying currencies remain open, significant price and rate movements may
take place in the underlying markets that are not reflected in the options
market.

     Stock Index Options. The Fund may invest in options on broadly based
indexes. Options on stock indexes are similar to options on stock except that,
rather than the right to take or make delivery of stock at a specified price,
an option on a stock index gives the holder the right to receive, upon exercise
of the option, an amount of cash if the closing level of the stock index upon
which the option is based is greater than, in the case of a call, or less than,
in the case of a put, the exercise price of the option. This amount of cash is
equal to such difference between the closing price of the index and the
exercise price of the option expressed in dollars times a specified multiple.
The writer of the option is obligated, in return for the premium received, to
make delivery of this amount.

     Risks of Options on Indexes. Because exercises of stock index options are
settled in cash, the Fund could not, if it wrote a call option, provide in
advance for its potential settlement obligations by acquiring and holding the
underlying securities. A call writer can offset some of the risk of its writing
position by holding a diversified portfolio of stocks similar to those on which
the underlying index is based. However, most investors cannot, as a practical
matter, acquire and hold a portfolio containing exactly the same stocks as the
underlying index, and, as a result, bear a risk that the value of the
securities held will vary from the value of the index. Even if an index call
writer could assemble a stock portfolio that exactly reproduced the composition
of the underlying index, the writer still would not be fully covered from a
risk standpoint because of the "timing risk" inherent in writing index options.



                                       7
<PAGE>

     When an index option is exercised, the amount of cash that the holder is
entitled to receive is determined by the difference between the exercise price
and the closing index level on the date when the option is exercised. As with
other kinds of options, the writer will not learn that it had been assigned
until the next business day, at the earliest. The time lag between exercise and
notice of assignment poses no risk for the writer of a covered call on a
specific underlying security, such as a common stock, because there the
writer's obligation is to deliver the underlying security, not to pay its value
as of a fixed time in the past. So long as the writer already owns the
underlying security, it can satisfy its settlement obligations by simply
delivering it, and the risk that its value may have declined since the exercise
date is borne by the exercising holder. In contrast, even if the writer of an
index call holds stocks that exactly match the composition of the underlying
index, it will not be able to satisfy its assignment obligations by delivering
those stocks against payment of the exercise price. Instead, it will be
required to pay cash in an amount based on the closing index value on the
exercise date; and by the time it learns that it has been assigned, the index
may have declined, with a corresponding decrease in the value of its stock
portfolio. This "timing risk" is an inherent limitation on the ability of index
call writers to cover their risk exposure by holding stock positions.

     A holder of an index option who exercises it before the closing index
value for that day is available runs the risk that the level of the underlying
index may subsequently change. If a change causes the exercised option to fall
out-of-the-money, the exercising holder will be required to pay the difference
between the closing index value and the exercise price of the option (times the
applicable multiplier) to the assigned writer.

     If dissemination of the current level of an underlying index is
interrupted, or if trading is interrupted in stocks accounting for a
substantial portion of the value of an index, the trading of options on that
index will ordinarily be halted. If the trading of options on an underlying
index is halted, an exchange may impose restrictions prohibiting the exercise
of such options.

     Futures Contracts. The Fund may purchase and sell interest rate, currency
and index futures contracts that are traded on U.S. and foreign commodity
exchanges on such underlying securities as U.S. Treasury bonds, notes, bills
and GNMA Certificates and/or any foreign government fixed-income security, on
various currencies and on such indexes of U.S. and foreign securities as may
exist or come into existence.

     A futures contract purchaser incurs an obligation to take delivery of a
specified amount of the obligation underlying the contract at a specified time
in the future for a specified price. A seller of a futures contract incurs an
obligation to deliver the specified amount of the underlying obligation at a
specified time in return for an agreed upon price. The purchase of a futures
contract enables the Fund, during the term of the contract, to lock in a price
at which it may purchase a security or currency and protect against a rise in
prices pending purchase of portfolio securities. The sale of a futures contract
enables the Fund to lock in a price at which it may sell a security or currency
and protect against declines in the value of portfolio securities.

     Although most futures contracts call for actual delivery or acceptance of
securities, the contracts usually are closed out before the settlement date
without the making or taking of delivery. Index futures contracts provide for
the delivery of an amount of cash equal to a specified dollar amount times the
difference between the index value at the open or close of the last trading day
of the contract and the futures contract price. A futures contract sale is
closed out by effecting a futures contract purchase for the same aggregate
amount of the specific type of security (currency) and the same delivery date.
If the sale price exceeds the offsetting purchase price, the seller would be
paid the difference and would realize a gain. If the offsetting purchase price
exceeds the sale price, the seller would pay the difference and would realize a
loss. Similarly, a futures contract purchase is closed out by effecting a
futures contract sale for the same aggregate amount of the specific type of
security (currency) and the same delivery date. If the offsetting sale price
exceeds the purchase price, the purchaser would realize a gain, whereas if the
purchase price exceeds the offsetting sale price, the purchaser would realize a
loss. There is no assurance that the Fund will be able to enter into a closing
transaction.


                                       8
<PAGE>

     Margin. If the Fund enters into a futures contract, it is initially
required to deposit an "initial margin" of cash or U.S. Government securities
or other liquid portfolio securities ranging from approximately 2% to 5% of the
contract amount. Initial margin requirements are established by the exchanges
on which futures contracts trade and may, from time to time, change. In
addition, brokers may establish margin deposit requirements in excess of those
required by the exchanges.

     Initial margin in futures transactions is different from margin in
securities transactions in that initial margin does not involve the borrowing
of funds by a broker's client but is, rather, a good faith deposit on the
futures contract which will be returned to the Fund upon the proper termination
of the futures contract. The margin deposits made are marked to market daily
and the Fund may be required to make subsequent deposits of cash or U.S.
Government securities, called "variation margin," which are reflective of price
fluctuations in the futures contract.

     Options on Futures Contracts. The Fund may purchase and write call and put
options on futures contracts and enter into closing transactions with respect
to such options to terminate an existing position. An option on a futures
contract gives the purchaser the right (in return for the premium paid), and
the writer the obligation, to assume a position in a futures contract (a long
position if the option is a call and a short position if the option is a put)
at a specified exercise price at any time during the term of the option. Upon
exercise of the option, the delivery of the futures position by the writer of
the option to the holder of the option is accompanied by delivery of the
accumulated balance in the writer's futures margin account, which represents
the amount by which the market price of the futures contract at the time of
exercise exceeds, in the case of a call, or is less than, in the case of a put,
the exercise price of the option on the futures contract.

     The writer of an option on a futures contract is required to deposit
initial and variation margin pursuant to requirements similar to those
applicable to futures contracts. Premiums received from the writing of an
option on a futures contract are included in initial margin deposits.

     Limitations on Futures Contracts and Options on Futures. The Fund may not
enter into futures contracts or purchase related options thereon if,
immediately thereafter, the amount committed to margin plus the amount paid for
premiums for unexpired options on futures contracts exceeds 5% of the value of
the Fund's total assets, after taking into account unrealized gains and
unrealized losses on such contracts it has entered into, provided, however,
that in the case of an option that is in-the-money (the exercise price of the
call (put) option is less (more) than the market price of the underlying
security) at the time of purchase, the in-the-money amount may be excluded in
calculating the 5%. However, there is no overall limitation on the percentage
of the Fund's net assets which may be subject to a hedge position.

     Risks of Transactions in Futures Contracts and Related Options. The prices
of securities and indexes subject to futures contracts (and thereby the futures
contract prices) may correlate imperfectly with the behavior of the cash prices
of the Fund's portfolio securities (and the currencies in which they are
denominated). Also, prices of futures contracts may not move in tandem with the
changes in prevailing interest rates, market movements and/or currency exchange
rates against which the Fund seeks a hedge. A correlation may also be distorted
(a) temporarily, by short-term traders' seeking to profit from the difference
between a contract or security price objective and their cost of borrowed
funds; (b) by investors in futures contracts electing to close out their
contracts through offsetting transactions rather than meet margin deposit
requirements; (c) by investors in futures contracts opting to make or take
delivery of underlying securities rather than engage in closing transactions,
thereby reducing liquidity of the futures market; and (d) temporarily, by
speculators who view the deposit requirements in the futures markets as less
onerous than margin requirements in the cash market. Due to the possibility of
price distortion in the futures market and because of the possible imperfect
correlation between movements in the prices of securities and movements in the
prices of futures contracts, a correct forecast of interest rate, currency
exchange rate and/or market movement trends by the Investment Manager may still
not result in a successful hedging transaction.

     There is no assurance that a liquid secondary market will exist for
futures contracts and related options in which the Fund may invest. In the
event a liquid market does not exist, it may not be possible to close out a
futures position and, in the event of adverse price movements, the Fund would
continue to be required to make daily cash payments of variation margin. The
absence of a liquid market in futures contracts might cause the Fund to make or
take delivery of the underlying securities (currencies) at a time when it may
be disadvantageous to do so.


                                       9
<PAGE>

     Exchanges also limit the amount by which the price of a futures contract
may move on any day. If the price moves equal the daily limit on successive
days, then it may prove impossible to liquidate a futures position until the
daily limit moves have ceased. In the event of adverse price movements, the
Fund would continue to be required to make daily cash payments of variation
margin on open futures positions. In these situations, if the Fund has
insufficient cash, it may have to sell portfolio securities to meet daily
variation margin requirements at a time when it may be disadvantageous to do
so. In addition, the Fund may be required to take or make delivery of the
instruments underlying interest rate futures contracts it holds at a time when
it is disadvantageous to do so. The inability to close out options and futures
positions could also have an adverse impact on the Fund's ability to
effectively hedges its portfolio.

     Futures contracts and options thereon which are purchased or sold on
foreign commodities exchanges may have greater price volatility than their U.S.
counterparts. Furthermore, foreign commodities exchanges may be less regulated
and under less governmental scrutiny than U.S. exchanges. Brokerage
commissions, clearing costs and other transaction costs may be higher on
foreign exchanges. Greater margin requirements may limit the Fund's ability to
enter into certain commodity transactions on foreign exchanges. Moreover,
differences in clearance and delivery requirements on foreign exchanges may
occasion delays in the settlement of the Fund's transactions effected on
foreign exchanges.

     In the event of the bankruptcy of a broker through which the Fund engages
in transactions in futures or options thereon, the Fund could experience delays
and/or losses in liquidating open postions purchased or sold through the broker
and/or incur a loss of all or part of its margin deposits with the broker.

     If the Fund maintains a short position in a futures contract or has sold a
call option in a futures contract, it will cover this position by holding, in a
segregated account maintained on the books of the Fund, cash, U.S. government
securities or other liquid portfolio securities equal in value (when added to
any initial or variation margin on deposit) to the market value of the
securities underlying the futures contract or the exercise price of the option.
Such a position may also be covered by owning the securities underlying the
futures contract (in the case of a stock index futures contract a portfolio of
securities substantially replicating the relevant index), or by holding a call
option permitting the Fund to purchase the same contract at a price no higher
than the price at which the short position was established.

     In addition, if the Fund holds a long position in a futures contract or
has sold a put option on a futures contract, it will hold cash, U.S. government
securities or other liquid portfolio securities equal to the purchase price of
the contract or the exercise price of the put option (less the amount of
initial or variation margin on deposit) in a segregated account maintained on
the books of the Fund. Alternatively, the Fund could cover its long position by
purchasing a put option on the same futures contract with an exercise price as
high or higher than the price of the contract held by the Fund.

     MONEY MARKET SECURITIES. The Fund may invest in various money market
securities for cash management purposes or when assuming a temporary defensive
position, which among others may include commercial paper, bank acceptances,
bank obligations, corporate debt securities, certificates of deposit, U.S.
Government securities, obligations of savings institutions and repurchase
agreements. Such securities are limited to:

     U.S. Government Securities. Obligations issued or guaranteed as to
principal and interest by the United States or its agencies (such as the
Export-Import Bank of the United States, Federal Housing Administration and
Government National Mortgage Association) or its instrumentalities (such as the
Federal Home Loan Bank), including Treasury bills, notes and bonds;

     Bank Obligations. Obligations (including certificates of deposit, time
deposits and bankers' acceptances) of banks subject to regulation by the U.S.
Government and having total assets of $1 billion or more, and instruments
secured by such obligations, not including obligations of foreign branches of
domestic banks except to the extent below;

     Eurodollar Certificates of Deposit. Eurodollar certificates of deposit
issued by foreign branches of domestic banks having total assets of $1 billion
or more;


                                       10
<PAGE>

     Obligations of Savings Institutions. Certificates of deposit of savings
banks and savings and loan associations, having total assets of $1 billion or
more;

     Fully Insured Certificates of Deposit. Certificates of deposit of banks
and savings institutions, having total assets of less than $1 billion, if the
principal amount of the obligation is federally insured by the Bank Insurance
Fund or the Savings Association Insurance Fund (each of which is administered
by the FDIC), limited to $100,000 principal amount per certificate and to 10%
or less of the Fund's total assets in all such obligations and in all illiquid
assets, in the aggregate;

     Commercial Paper. Commercial paper rated within the two highest grades by
Standard & Poor's Corporation ("S&P") or the two highest grade by Moody's
Investors Service, Inc. ("Moody's") or, if not rated, issued by a company
having an outstanding debt issue rated at least AA by S&P or Aa by Moody's; and

     Repurchase Agreements. The Fund may invest in repurchase agreements. When
cash may be available for only a few days, it may be invested by the Fund in
repurchase agreements until such time as it may otherwise be invested or used
for payments of obligations of the Fund. These agreements, which may be viewed
as a type of secured lending by the Fund, typically involve the acquisition by
the Fund of debt securities from a selling financial institution such as a
bank, savings and loan association or broker-dealer. The agreement provides
that the Fund will sell back to the institution, and that the institution will
repurchase, the underlying security serving as collateral at a specified price
and at a fixed time in the future, usually not more than seven days from the
date of purchase. The collateral will be marked-to-market daily to determine
that the value of the collateral, as specified in the agreement, does not
decrease below the purchase price plus accrued interest. If such decrease
occurs, additional collateral will be requested and, when received, added to
the account to maintain full collateralization. The Fund will accrue interest
from the institution until the time when the repurchase is to occur. Although
this date is deemed by the Fund to be the maturity date of a repurchase
agreement, the maturities of securities subject to repurchase agreements are
not subject to any limits.

     While repurchase agreements involve certain risks not associated with
direct investments in debt securities, the Fund follows procedures designed to
minimize such risks. These procedures include effecting repurchase transactions
only with large, well-capitalized and well-established financial institutions
whose financial condition will be continually monitored by the Investment
Manager subject to procedures established by the Trustees. In addition, as
described above, the value of the collateral underlying the repurchase
agreement will be at least equal to the repurchase price, including any accrued
interest earned on the repurchase agreement. In the event of a default or
bankruptcy by a selling financial institution, the Fund will seek to liquidate
such collateral. However, the exercising of the Fund's right to liquidate such
collateral could involve certain costs or delays and, to the extent that
proceeds from any sale upon a default of the obligation to repurchase were less
than the repurchase price, the Fund could suffer a loss.

     REVERSE REPURCHASE AGREEMENTS. The Fund may also use reverse repurchase
agreements. Reverse repurchase agreements involve sales by the Fund of
portfolio assets concurrently with an agreement by the Fund to repurchase the
same assets at a later date at a fixed price. Generally, the effect of such a
transaction is that the Fund can recover all or most of the cash invested in
the portfolio securities involved during the term of the reverse repurchase
agreement, while it will be able to keep the interest income associated with
those portfolio securities. These transactions are only advantageous if the
interest cost to the Fund of the reverse repurchase transaction is less than
the cost of obtaining the cash otherwise. Opportunities to achieve this
advantage may not always be available, and the Fund intends to use the reverse
repurchase technique only when it will be to its advantage to do so.

     The Fund will establish a segregated account in which it will maintain
cash, U.S. Government securities or other liquid portfolio securities equal in
value to its obligations in respect of reverse repurchase agreements. Reverse
repurchase agreements involve the risk that the market value of the securities
the Fund is obligated to repurchase under the agreement may decline below the
repurchase price. In the event the buyer of securities under a reverse
repurchase agreement files for bankruptcy or becomes insolvent, the Fund's use
of proceeds of the agreement may be restricted pending a


                                       11
<PAGE>

determination by the other party, or its trustee or receiver, whether to
enforce the Fund's obligation to repurchase the securities. Reverse repurchase
agreements are speculative techniques involving leverage, and are considered
borrowings by the Fund.

     CONVERTIBLE SECURITIES. The Fund may invest in fixed-income securities
which are convertible into common stock. Convertible securities rank senior to
common stocks in a corporation's capital structure and, therefore, entail less
risk than the corporation's common stock. The value of a convertible security
is a function of its "investment value" (its value as if it did not have a
conversion privilege), and its "conversion value" (the security's worth if it
were to be exchanged for the underlying security, at market value, pursuant to
its conversion privilege).

     To the extent that a convertible security's investment value is greater
than its conversion value, its price will be primarily a reflection of such
investment value and its price will be likely to increase when interest rates
fall and decrease when interest rates rise, as with a fixed-income security
(the credit standing of the issuer and other factors may also have an effect on
the convertible security's value). If the conversion value exceeds the
investment value, the price of the convertible security will rise above its
investment value and, in addition, will sell at some premium over its
conversion value. (This premium represents the price investors are willing to
pay for the privilege of purchasing a fixed-income security with a possibility
of capital appreciation due to the conversion privilege.) At such times the
price of the convertible security will tend to fluctuate directly with the
price of the underlying equity security. Convertible securities may be
purchased by the Fund at varying price levels above their investment values
and/or their conversion values in keeping with the Fund's objective.

     ZERO COUPON SECURITIES. A portion of the U.S. government securities
purchased by the Fund may be zero coupon securities. Such securities are
purchased at a discount from their face amount, giving the purchaser the right
to receive their full value at maturity. The interest earned on such securities
is, implicitly, automatically compounded and paid out at maturity. While such
compounding at a constant rate eliminates the risk of receiving lower yields
upon reinvestment of interest if prevailing interest rates decline, the owner
of a zero coupon security will be unable to participate in higher yields upon
reinvestment of interest received on interest-paying securities if prevailing
interest rates rise.

     A zero coupon security pays no interest to its holder during its life.
Therefore, to the extent the Fund invests in zero coupon securities, it will
not receive current cash available for distribution to shareholders. In
addition, zero coupon securities are subject to substantially greater price
fluctuations during periods of changing prevailing interest rates than are
comparable securities which pay interest on a current basis. Current federal
tax law requires that a holder (such as the Fund) of a zero coupon security
accrue a portion of the discount at which the security was purchased as income
each year even though the Fund receives no interest payments in cash on the
security during the year.

     LENDING PORTFOLIO SECURITIES. The Fund may lend its portfolio securities
to brokers, dealers and other financial institutions, provided that the loans
are callable at any time by the Fund, and are at all times secured by cash or
cash equivalents, which are maintained in a segregated account pursuant to
applicable regulations and that are equal to at least 100% of the market value,
determined daily, of the loaned securities. The advantage of these loans is
that the Fund continues to receive the income on the loaned securities while at
the same time earning interest on the cash amounts deposited as collateral,
which will be invested in short-term obligations. The Fund will not lend more
than 25% of the value of its total assets.

     As with any extensions of credit, there are risks of delay in recovery
and, in some cases, even loss of rights in the collateral should the borrower
of the securities fail financially. However, these loans of portfolio
securities will only be made to firms deemed by the Fund's management to be
creditworthy and when the income which can be earned from such loans justifies
the attendant risks. Upon termination of the loan, the borrower is required to
return the securities to the Fund. Any gain or loss in the market price during
the loan period would inure to the Fund.

     When voting or consent rights which accompany loaned securities pass to
the borrower, the Fund will follow the policy of calling the loaned securities,
to be delivered within one day after notice, to permit the exercise of the
rights if the matters involved would have a material effect on the Fund's
investment in the loaned securities. The Fund will pay reasonable finder's,
administrative and custodial fees in connection with a loan of its securities.


                                       12
<PAGE>

     WHEN-ISSUED AND DELAYED DELIVERY SECURITIES AND FORWARD COMMITMENTS. From
time to time the Fund may purchase securities on a when-issued or delayed
delivery basis or may purchase or sell securities on a forward commitment
basis. When these transactions are negotiated, the price is fixed at the time
of the commitment, but delivery and payment can take place a month or more
after the date of commitment. While the Fund will only purchase securities on a
when-issued, delayed delivery or forward commitment basis with the intention of
acquiring the securities, the Fund may sell the securities before the
settlement date, if it is deemed advisable. The securities so purchased or sold
are subject to market fluctuation and no interest or dividends accrue to the
purchaser prior to the settlement date.

     At the time the Fund makes the commitment to purchase or sell securities
on a when-issued, delayed delivery or forward commitment basis, it will record
the transaction and thereafter reflect the value, each day, of such security
purchased, or if a sale, the proceeds to be received, in determining its net
asset value. At the time of delivery of the securities, their value may be more
or less than the purchase or sale price. An increase in the percentage of the
Fund's assets committed to the purchase of securities on a when-issued, delayed
delivery or forward commitment basis may increase the volatility of its net
asset value. The Fund will also establish a segregated account on the Fund's
books in which it will continually maintain cash or cash equivalents or other
liquid portfolio securities equal in value to commitments to purchase
securities on a when-issued, delayed delivery or forward commitment basis.

     WHEN, AS AND IF ISSUED SECURITIES. The Fund may purchase securities on a
"when, as and if issued" basis under which the issuance of the security depends
upon the occurrence of a subsequent event, such as approval of a merger,
corporate reorganization or debt restructuring. The commitment for the purchase
of any such security will not be recognized in the portfolio of the Fund until
the Investment Manager determines that issuance of the security is probable. At
that time, the Fund will record the transaction and, in determining its net
asset value, will reflect the value of the security daily. At that time, the
Fund will also establish a segregated account on the Fund's books in which it
will maintain cash or cash equivalents or other liquid portfolio securities
equal in value to recognized commitments for such securities.

     An increase in the percentage of the Fund's assets committed to the
purchase of securities on a "when, as and if issued" basis may increase the
volatility of its net asset value. The Fund may also sell securities on a
"when, as and if issued" basis provided that the issuance of the security will
result automatically from the exchange or conversion of a security owned by the
Fund at the time of sale.

     PRIVATE PLACEMENTS. The Fund may invest up to 15% of its net assets in
securities which are subject to restrictions on resale because they have not
been registered under the Securities Act of 1933 (the "Securities Act"), or
which are otherwise not readily marketable. (Securities eligible for resale
pursuant to Rule 144A under the Securities Act, and determined to be liquid
pursuant to the procedures discussed in the following paragraph, are not
subject to the foregoing restriction.) These securities are generally referred
to as private placements or restricted securities. Limitations on the resale of
these securities may have an adverse effect on their marketability, and may
prevent the Fund from disposing of them promptly at reasonable prices. The Fund
may have to bear the expense of registering the securities for resale and the
risk of substantial delays in effecting the registration.

     Rule 144A permits the Fund to sell restricted securities to qualified
institutional buyers without limitation. The Investment Manager, pursuant to
procedures adopted by the Trustees, will make a determination as to the
liquidity of each restricted security purchased by the Fund. If a restricted
security is determined to be "liquid," the security will not be included within
the category "illiquid securities," which may not exceed 15% of the Fund's net
assets. However, investing in Rule 144A securities could have the effect of
increasing the level of Fund illiquidity to the extent the Fund, at a
particular point in time, may be unable to find qualified institutional buyers
interested in purchasing such securities.

     WARRANTS AND SUBSCRIPTION RIGHTS. Subject to the Fund's investment
restrictions, the Fund may acquire warrants. A warrant is, in effect, an option
to purchase equity securities at a specific price, generally valid for a
specific period of time, and has no voting rights, pays no dividends and has no
rights with respect to the corporation issuing it.


                                       13
<PAGE>


     A subscription right is a privilege granted to existing shareholders of a
corporation to subscribe to shares of a new issue of common stock before it is
offered to the public. A subscription right normally has a life of two to four
weeks and a subscription price lower than the current market value of the
common stock.


     YEAR 2000. The investment management services provided to the Fund by the
Investment Manager and the services provided to shareholders by the Distributor
and the Transfer Agent depend on the smooth functioning of their computer
systems. Many computer software systems in use today cannot recognize the year
2000, but revert to 1900 or some other date, due to the manner in which dates
were encoded and calculated. That failure could have a negative impact on the
handling of securities trades, pricing and account services. The Investment
Manager, the Distributor and the Transfer Agent have been actively working on
necessary changes to their own computer systems to prepare for the year 2000
and expect that their systems will be adapted before that date, but there can
be no assurance that they will be successful, or that interaction with other
non-complying computer systems will not impair their services at that time.

     In addition, it is possible that the markets for securities in which the
Fund invests may be detrimentally affected by computer failures throughout the
financial services industry beginning January 1, 2000. Improperly functioning
trading systems may result in settlement problems and liquidity issues.
Corporate and governmental data processing errors also may result in production
problems for individual companies and overall economic uncertainties. Earnings
of individual issuers will be affected by remediation costs, which may be
substantial and may be reported inconsistently in U.S. and foreign financial
statements. Accordingly, the Fund's investments may be adversely affected.

C. FUND POLICIES/INVESTMENT RESTRICTIONS

     The investment objective, policies and restrictions listed below have been
adopted by the Fund as fundamental policies. Under the Investment Company Act
of 1940 (the "Investment Company Act"), a fundamental policy may not be changed
without the vote of a majority of the outstanding voting securities of the
Fund. The Investment Company Act defines a majority as the lesser of (a) 67% or
more of the shares present at a meeting of shareholders, if the holders of 50%
of the outstanding shares of the Fund are present or represented by proxy; or
(b) more than 50% of the outstanding shares of the Fund. For purposes of the
following restrictions: (i) all percentage limitations apply immediately after
a purchase or initial investment; and (ii) any subsequent change in any
applicable percentage resulting from market fluctuations or other changes in
total or net assets does not require elimination of any security from the
portfolio.

     The Fund will:

    1. Seek capital appreciation.

     The Fund may not:

    1. Invest 25% or more of the value of its total assets in securities of
       issuers in any one industry, except the Fund will invest at least 25% of
       the value of its total assets in the health sciences industry.


    2. Invest more than 5% of the value of its total assets in securities of
       issuers having a record, together with predecessors, of less than three
       years of continuous operation. This restriction shall not apply to any
       obligation issued or guaranteed by the United States Government, its
       agencies or instrumentalities.


    3. Purchase or sell commodities or commodities contracts, except the Fund
       may purchase or write (sell) interest rate, currency and stock and bond
       index futures contracts and related options thereon.

    4. Pledge its assets or assign or otherwise encumber them except to secure
       permitted borrowings. (For the purpose of this restriction, collateral
       arrangements with respect to the writing of options and collateral
       arrangements with respect to initial or variation margin for futures are
       not deemed to be pledges of assets.)


                                       14
<PAGE>

    5. Purchase securities on margin (but the Fund may obtain short-term loans
       as are necessary for the clearance of transactions). The deposit or
       payment by the Fund of initial or variation margin in connection with
       futures contracts or related options thereon is not considered the
       purchase of a security on margin.

    6. Purchase or sell real estate or interests therein, although the Fund
       may purchase securities of issuers which engage in real estate
       operations and securities secured by real estate or interests therein.

    7. Purchase oil, gas or other mineral leases, rights or royalty contracts
       or exploration or development programs, except that the Fund may invest
       in the securities of companies which operate, invest in, or sponsor such
       programs.

    8. Purchase securities of other investment companies, except in connection
       with a merger, consolidation, reorganization or acquisition of assets
       or, in the case of a closed-end company, in accordance with the
       provisions of Section 12(d) of the Act and any Rules promulgated
       thereunder.

    9. Borrow money (except insofar as the Fund may be deemed to have borrowed
       by entrance into a reverse repurchase agreement up to an amount not
       exceeding 10% of the Fund's total assets), except that the Fund may
       borrow from a bank for temporary or emergency purposes in amounts not
       exceeding 5% (taken at the lower of cost or current value) of its total
       assets (not including the amount borrowed).

   10. Issue senior securities as defined in the Act except insofar as the
       Fund may be deemed to have issued a senior security by reason of: (a)
       entering into any repurchase or reverse repurchase agreement; (b)
       purchasing any securities on a when-issued or delayed delivery basis;
       (c) purchasing or selling futures contracts, forward foreign exchange
       contracts or options; (d) borrowing money in accordance with
       restrictions described above; or (e) lending portfolio securities.

   11. Make loans of money or securities, except by: (a) the purchase of
       publicly distributed debt obligations; (b) investment in repurchase or
       reverse repurchase agreements; or (c) lending its portfolio securities.

   12. Make short sales of securities or maintain a short position, unless at
       all times when a short position is open it either owns an equal amount
       of such securities or owns securities which, without payment of any
       further consideration, are convertible into or exchangeable for
       securities of the same issue as, and equal in amount to, the securities
       sold short.

   13. Engage in the underwriting of securities, except insofar as the Fund
       may be deemed an underwriter under the Securities Act of 1933 in
       disposing of a portfolio security.

   14. Invest for the purpose of exercising control or management of any other
       issuer.

   15. Invest more than 5% of its net assets in warrants, including not more
       than 2% of such net assets in warrants not listed on either a recognized
       domestic or foreign exchange. However, the acquisition of warrants
       attached to other securities is not subject to this restriction.

     Notwithstanding any other investment policy or restriction, the Fund may
seek to achieve its investment objective by investing all or substantially all
of its assets in another investment company having substantially the same
investment objective and policies as the Fund.

III. MANAGEMENT OF THE FUND
- --------------------------------------------------------------------------------
A. BOARD OF TRUSTEES

     The Board of Trustees of the Fund oversees the management of the Fund but
does not itself manage the Fund. The Trustees review various services provided
by or under the direction of the Investment Manager to ensure that the Fund's
general investment policies and programs are properly carried out. The Trustees
also conduct their review to ensure that administrative services are provided
to the Fund in a satisfactory manner.


                                       15
<PAGE>

     Under state law, the duties of the Trustees are generally characterized as
a duty of loyalty and a duty of care. The duty of loyalty requires a Trustee to
exercise his or her powers in the interest of the Fund and not the Trustee's
own interest or the interest of another person or organization. A Trustee
satisfies his or her duty of care by acting in good faith with the care of an
ordinarily prudent person and in a manner the Trustee reasonably believes to be
in the best interest of the Fund and its shareholders.


B. MANAGEMENT INFORMATION


     TRUSTEES AND OFFICERS. The Board of the Fund consists of eight (8)
Trustees. These same individuals also serve as directors or trustees for all of
the Morgan Stanley Dean Witter Funds. Six Trustees (75% of the total number)
have no affiliation or business connection with the Investment Manager or any
of its affiliated persons and do not own any stock or other securities issued
by the Investment Manager's parent company, MSDW. These are the
"non-interested" or "independent" Trustees. The other two Trustees (the
"management Trustees") are affiliated with the Investment Manager. All of the
Trustees also serve as Trustees of "Discover Brokerage Index Series," a mutual
fund for which the Investment Manager is the investment advisor.



     The Trustees and executive officers of the Fund, their principal business
occupations during the last five years and their affiliations, if any, with the
Investment Manager, and with the 91 Morgan Stanley Dean Witter Funds and
Discover Brokerage Index Series, are shown below.





<TABLE>
<CAPTION>
 NAME, AGE, POSITION WITH FUND AND ADDRESS        PRINCIPAL OCCUPATIONS DURING LAST FIVE YEARS
- -------------------------------------------   ---------------------------------------------------
<S>                                           <C>
Michael Bozic (58) ........................   Vice Chairman of Kmart Corporation (since
Trustee                                       December, 1998); Director or Trustee of the Morgan
c/o Kmart Corporation                         Stanley Dean Witter Funds and Discover Brokerage
3100 West Big Beaver Road                     Index Series; formerly Chairman and Chief
Troy, Michigan                                Executive Officer of Levitz Furniture Corporation
                                              (November, 1995-November, 1998) and President
                                              and Chief Executive Officer of Hills Department
                                              Stores (May, 1991-July, 1995); formerly variously
                                              Chairman, Chief Executive Officer, President and
                                              Chief Operating Officer (1987-1991) of the Sears
                                              Merchandise Group of Sears, Roebuck and Co.;
                                              Director of Eaglemark Financial Services, Inc. and
                                              Weirton Steel Corporation.

Charles A. Fiumefreddo* (66) ..............   Chairman, Director or Trustee and Chief Executive
Chairman of the Board,                        Officer of the Morgan Stanley Dean Witter Funds
Chief Executive Officer and Trustee           and Discover Brokerage Index Series; formerly
Two World Trade Center                        Chairman, Chief Executive Officer and Director of
New York, New York                            the Investment Manager, the Distributor and MSDW
                                              Services Company; Executive Vice President and
                                              Director of Dean Witter Reynolds; Chairman and
                                              Director of the Transfer Agent; formerly Director
                                              and/or officer of various MSDW subsidiaries (until
                                              June 1998).
</TABLE>

                                       16
<PAGE>


<TABLE>
<CAPTION>
 NAME, AGE, POSITION WITH FUND AND ADDRESS          PRINCIPAL OCCUPATIONS DURING LAST FIVE YEARS
- -------------------------------------------   --------------------------------------------------------
<S>                                           <C>
Edwin J. Garn (66) ........................   Director or Trustee of the Morgan Stanley Dean
Trustee                                       Witter Funds and Discover Brokerage Index Series;
c/o Huntsman Corporation                      formerly United States Senator (R-Utah)
500 Huntsman Way                              (1974-1992) and Chairman, Senate Banking
Salt Lake City, Utah                          Committee (1980-1986); formerly Mayor of Salt
                                              Lake City, Utah (1971-1974); formerly Astronaut,
                                              Space Shuttle Discovery (April 12-19, 1985); Vice
                                              Chairman, Huntsman Corporation (chemical
                                              company); Director of Franklin Covey (time
                                              management systems), BMW Bank of North
                                              America, Inc. (industrial loan corporation), United
                                              Space Alliance (joint venture between Lockheed
                                              Martin and the Boeing Company) and Nuskin Asia
                                              Pacific (multilevel marketing); member of the board
                                              of various civic and charitable organizations.

Wayne E. Hedien (65) ......................   Retired; Director or Trustee of the Morgan Stanley
Trustee                                       Dean Witter Funds and Discover Brokerage Index
c/o Mayer, Brown & Platt                      Series; Director of The PMI Group, Inc. (private
Counsel to the Independent Trustees           mortgage insurance); Trustee and Vice Chairman of
1675 Broadway                                 The Field Museum of Natural History; formerly
New York, New York                            associated with the Allstate Companies (1966-1994),
                                              most recently as Chairman of The Allstate Corporation
                                              (March, 1993-December, 1994) and Chairman and
                                              Chief Executive Officer of its wholly-owned subsidiary,
                                              Allstate Insurance Company (July, 1989-December,
                                              1994); director of various other business and
                                              charitable organizations.

Dr. Manuel H. Johnson (50) ................   Senior Partner, Johnson Smick International, Inc.,
Trustee                                       a consulting firm; Co-Chairman and a founder of
c/o Johnson Smick International, Inc.         the Group of Seven Council (G7C), an international
1133 Connecticut Avenue, N.W.                 economic commission; Chairman of the Audit
Washington, D.C.                              Committee and Director or Trustee of the Morgan
                                              Stanley Dean Witter Funds and Discover Brokerage
                                              Index Series; Director of Greenwich Capital
                                              Markets, Inc. (broker-dealer) and NVR, Inc. (home
                                              construction); Chairman and Trustee of the
                                              Financial Accounting Foundation (oversight
                                              organization of the Financial Accounting Standards
                                              Board); formerly Vice Chairman of the Board of
                                              Governors of the Federal Reserve System
                                              (1986-1990) and Assistant Secretary of the U.S.
                                              Treasury.

Michael E. Nugent (63) ....................   General Partner, Triumph Capital, L.P., a private
Trustee                                       investment partnership; Chairman of the Insurance
c/o Triumph Capital, L.P.                     Committee and Director or Trustee of the Morgan
237 Park Avenue                               Stanley Dean Witter Funds and Discover Brokerage
New York, New York                            Index Series; formerly Vice President, Bankers Trust
                                              Company and BT Capital Corporation (1984-1988);
                                              director of various business organizations.
</TABLE>

                                       17
<PAGE>



<TABLE>
<CAPTION>
 NAME, AGE, POSITION WITH FUND AND ADDRESS         PRINCIPAL OCCUPATIONS DURING LAST FIVE YEARS
- -------------------------------------------   ------------------------------------------------------
<S>                                           <C>
Philip J. Purcell* (56) ...................   Chairman of the Board of Directors and Chief
Trustee                                       Executive Officer of MSDW, Dean Witter Reynolds
1585 Broadway                                 and Novus Credit Services Inc.; Director of the
New York, New York                            Distributor; Director or Trustee of the Morgan
                                              Stanley Dean Witter Funds and Discover Brokerage
                                              Index Series; Director and/or officer of various
                                              MSDW subsidiaries.

John L. Schroeder (69) ....................   Retired; Chairman of the Derivatives Committee
Trustee                                       and Director or Trustee of the Morgan Stanley
c/o Mayer, Brown & Platt                      Dean Witter Funds and Discover Brokerage Index
Counsel to the Independent Trustees           Series; Director of Citizens Utilities Company
1675 Broadway                                 (telecommunications, gas, electric and water
New York, New York                            utilities company); formerly Executive Vice
                                              President and Chief Investment Officer of the
                                              Home Insurance Company (August, 1991-
                                              September, 1995).

Mitchell M. Merin (46) ....................   President and Chief Operating Officer of Asset
President                                     Management of MSDW (since December, 1998);
Two World Trade Center                        President and Director (since April, 1997) and
New York, New York                            Chief Executive Officer (since June, 1998) of the
                                              Investment Manager and MSDW Services
                                              Company; Chairman, Chief Executive Officer and
                                              Director of the Distributor (since June, 1998);
                                              Chairman and Chief Executive Officer (since June,
                                              1998) and Director (since January, 1998) of the
                                              Transfer Agent; Director of various MSDW
                                              subsidiaries; President of the Morgan Stanley Dean
                                              Witter Funds and Discover Brokerage Index Series
                                              (since May, 1999); previously Chief Strategic Officer
                                              of the Investment Manager and MSDW Services
                                              Company and Executive Vice President of the
                                              Distributor (April, 1997-June, 1998), Vice President
                                              of the Morgan Stanely Dean Witter Funds and
                                              Discover Brokerage Index Series (May, 1997-April,
                                              1999), and Executive Vice President of Dean
                                              Witter, Discover & Co.

Barry Fink (44) ...........................   Senior Vice President (since March, 1997) and
Vice President, Secretary                     Secretary and General Counsel (since February,
and General Counsel                           1997) and Director (since July, 1998) of the
Two World Trade Center                        Investment Manager and MSDW Services
New York, New York                            Company; Senior Vice President (since March,
                                              1997) and Assistant Secretary and Assistant
                                              General Counsel (since February, 1997) of the
                                              Distributor; Assistant Secretary of Dean Witter
                                              Reynolds (since August, 1996); Vice President,
                                              Secretary and General Counsel of the Morgan
                                              Stanley Dean Witter Funds (since February, 1997);
                                              Vice President, Secretary and General Counsel of
                                              Discover Brokerage Index Series; previously First
                                              Vice President (June, 1993-February, 1997), Vice
                                              President and Assistant Secretary and Assistant
                                              General Counsel of the Investment Manager and
                                              MSDW Services Company and Assistant Secretary
                                              of the Morgan Stanley Dean Witter Funds.
</TABLE>


                                       18
<PAGE>


<TABLE>
<CAPTION>
 NAME, AGE, POSITION WITH FUND AND ADDRESS        PRINCIPAL OCCUPATIONS DURING LAST FIVE YEARS
- -------------------------------------------   ----------------------------------------------------
<S>                                           <C>
Teresa McRoberts (41) .....................   Vice President of the Investment Manager (since
Vice President                                June, 1998); formerly Senior Analyst at Fred Alger
Two World Trade Center                        Management (July, 1994-May, 1998).
New York, New York

Thomas F. Caloia (53) .....................   First Vice President and Assistant Treasurer of the
Treasurer                                     Investment Manager, the Distributor and MSDW
Two World Trade Center                        Services Company; Treasurer of the Morgan
New York, New York                            Stanley Dean Witter Funds and Discover Brokerage
                                              Index Series.
</TABLE>

- ----------
* Denotes Trustees who are "interested persons" of the Fund as defined by the
   Investment Company Act.


     In addition, Ronald E. Robison, Executive Vice President, Chief
Administrative Officer and Director of the Investment Manager and MSDW Services
Company, Robert S. Giambrone, Senior Vice President of the Investment Manager,
MSDW Services Company, the Distributor and the Transfer Agent and Director of
the Transfer Agent, and Joseph J. McAlinden, Executive Vice President and Chief
Investment Officer of the Investment Manager and Director of the Transfer
Agent, and Kenton J. Hinchliffe, Ira N. Ross and Paul D. Vance, Senior Vice
Presidents of the Investment Manager, are Vice Presidents of the Fund.

     In addition, Frank Bruttomesso, Marilyn K. Cranney, Lou Anne D. McInnis,
Carsten Otto and Ruth Rossi, First Vice Presidents and Assistant General
Counsels of the Investment Manager and MSDW Services Company, Todd Lebo, Vice
President and Assistant General Counsel of the Investment Manager and MSDW
Services Company and Natasha Kassian, a Staff Attorney with the Investment
Manager, are Assistant Secretaries of the Fund.

     INDEPENDENT DIRECTORS/TRUSTEES AND THE COMMITTEES. Law and regulation
establish both general guidelines and specific duties for the independent
directors/trustees. The Morgan Stanley Dean Witter Funds seek as independent
directors/trustees individuals of distinction and experience in business and
finance, government service or academia; these are people whose advice and
counsel are in demand by others and for whom there is often competition. To
accept a position on the Funds' boards, such individuals may reject other
attractive assignments because the Funds make substantial demands on their
time. All of the independent directors/trustees serve as members of the Audit
Committee. In addition, three of the directors/trustees, including two
independent directors/trustees, serve as members of the Derivatives Committee
and the Insurance Committee.

     The independent directors/trustees are charged with recommending to the
full board approval of management, advisory and administration contracts, Rule
12b-1 plans and distribution and underwriting agreements; continually reviewing
Fund performance; checking on the pricing of portfolio securities, brokerage
commissions, transfer agent costs and performance, and trading among Funds in
the same complex; and approving fidelity bond and related insurance coverage
and allocations, as well as other matters that arise from time to time. The
independent directors/trustees are required to select and nominate individuals
to fill any independent director/trustee vacancy on the board of any Fund that
has a Rule 12b-1 plan of distribution. Most of the Morgan Stanley Dean Witter
Funds have a Rule 12b-1 plan.

     The Audit Committee is charged with recommending to the full board the
engagement or discharge of the Fund's independent accountants; directing
investigations into matters within the scope of the independent accountants'
duties, including the power to retain outside specialists; reviewing with the
independent accountants the audit plan and results of the auditing engagement;
approving professional services provided by the independent accountants and
other accounting firms prior to the performance of the services; reviewing the
independence of the independent accountants; considering the range of audit and
non-audit fees; reviewing the adequacy of the Fund's system of internal
controls; and preparing and submitting Committee meeting minutes to the full
board.


                                       19
<PAGE>

     The board of each Fund has a Derivatives Committee to approve parameters
for and monitor the activities of the Fund with respect to derivative
investments, if any, made by the Fund.

     Finally, the board of each Fund has formed an Insurance Committee to
review and monitor the insurance coverage maintained by the Fund.

     ADVANTAGES OF HAVING SAME INDIVIDUALS AS INDEPENDENT DIRECTORS/TRUSTEES
FOR ALL MORGAN STANLEY DEAN WITTER FUNDS. The independent directors/trustees
and the Funds' management believe that having the same independent
directors/trustees for each of the Morgan Stanley Dean Witter Funds avoids the
duplication of effort that would arise from having different groups of
individuals serving as independent directors/trustees for each of the Funds or
even of sub-groups of Funds. They believe that having the same individuals
serve as independent directors/trustees of all the Funds tends to increase
their knowledge and expertise regarding matters which affect the Fund complex
generally and enhances their ability to negotiate on behalf of each Fund with
the Fund's service providers. This arrangement also precludes the possibility
of separate groups of independent directors/trustees arriving at conflicting
decisions regarding operations and management of the Funds and avoids the cost
and confusion that would likely ensue. Finally, having the same independent
directors/trustees serve on all Fund boards enhances the ability of each Fund
to obtain, at modest cost to each separate Fund, the services of independent
directors/trustees, of the caliber, experience and business acumen of the
individuals who serve as independent directors/trustees of the Morgan Stanley
Dean Witter Funds.

     TRUSTEE AND OFFICER INDEMNIFICATION. The Fund's Declaration of Trust
provides that no Trustee, officer, employee or agent of the Fund is liable to
the Fund or to a shareholder, nor is any Trustee, officer, employee or agent
liable to any third persons in connection with the affairs of the Fund, except
as such liability may arise from his/her or its own bad faith, willful
misfeasance, gross negligence or reckless disregard of his/her or its duties.
It also provides that all third persons shall look solely to the Fund property
for satisfaction of claims arising in connection with the affairs of the Fund.
With the exceptions stated, the Declaration of Trust provides that a Trustee,
officer, employee or agent is entitled to be indemnified against all liability
in connection with the affairs of the Fund.


C. COMPENSATION

     The Fund pays each Independent Trustee an annual fee of $800 plus a per
meeting fee of $50 for meetings of the Board of Trustees, the Independent
Trustees or Committees of the Board of Trustees attended by the Trustee (the
Fund pays the Chairman of the Audit Committee an additional annual fee of $750
and the Chairmen of the Derivatives and Insurance Committees additional annual
fees of $500). If a Board meeting and a meeting of the Independent Trustees or
a Committee meeting, or a meeting of the Independent Trustees and/or more than
one Committee meeting, take place on a single day, the Trustees are paid a
single meeting fee by the Fund. The Fund also reimburses such Trustees for
travel and other out-of-pocket expenses incurred by them in connection with
attending such meetings. Trustees and officers of the Fund who are or have been
employed by the Investment Manager or an affiliated company receive no
compensation or expense reimbursement from the Fund for their services as
Trustee.

     The following table illustrates the compensation that the Fund paid to its
Independent Trustees for the fiscal year ended July 31, 1999.


                               FUND COMPENSATION



<TABLE>
<CAPTION>
                                     AGGREGATE
                                   COMPENSATION
NAME OF INDEPENDENT TRUSTEE        FROM THE FUND
- -------------------------------   --------------
<S>                               <C>
Michael Bozic .................       $1,450
Edwin J. Garn .................        1,600
Wayne E. Hedien ...............        1,650
Dr. Manuel H. Johnson .........        1,913
Michael E. Nugent .............        1,808
John L. Schroeder .............        1,808
</TABLE>


                                       20
<PAGE>

     The following table illustrates the compensation paid to the Fund's
Independent Trustees for the calendar year ended December 31, 1998 for services
to the 90 Morgan Stanley Dean Witter Funds that were in operation at December
31, 1998. No compensation was paid to the Fund's Independent Trustees by
Discover Brokerage Index Series for the calendar year ended December 31, 1998.


            CASH COMPENSATION FROM MORGAN STANLEY DEAN WITTER FUNDS




<TABLE>
<CAPTION>
                                     TOTAL CASH
                                    COMPENSATION
                                 FOR SERVICES TO 90
                                   MORGAN STANLEY
                                    DEAN WITTER
NAME OF INDEPENDENT TRUSTEE            FUNDS
- ------------------------------- -------------------
<S>                             <C>
Michael Bozic .................       $120,150
Edwin J. Garn .................        132,450
Wayne E. Hedien ...............        132,350
Dr. Manuel H. Johnson .........        155,681
Michael E. Nugent .............        159,731
John L. Schroeder .............        160,731
</TABLE>

     As of the date of this Statement of Additional Information, 55 of the
Morgan Stanley Dean Witter Funds, including the Fund, have adopted a retirement
program under which an independent director/  trustee who retires after serving
for at least five years (or such lesser period as may be determined by the
Board) as an independent director/trustee of any Morgan Stanley Dean Witter
Fund that has adopted the retirement program (each such Fund referred to as an
"Adopting Fund" and each such director/  trustee referred to as an "Eligible
Trustee") is entitled to retirement payments upon reaching the eligible
retirement age (normally, after attaining age 72). Annual payments are based
upon length of service.


     Currently, upon retirement, each Eligible Trustee is entitled to receive
from the Adopting Fund, commencing as of his or her retirement date and
continuing for the remainder of his or her life, an annual retirement benefit
(the "Regular Benefit") equal to 30.22% of his or her Eligible Compensation
plus 0.5036667% of such Eligible Compensation for each full month of service as
an independent director/ trustee of any Adopting Fund in excess of five years
up to a maximum of 60.44% after ten years of service. The foregoing percentages
may be changed by the Board.(1) "Eligible Compensation" is one-fifth of the
total compensation earned by such Eligible Trustee for service to the Adopting
Fund in the five year period prior to the date of the Eligible Trustee's
retirement. Benefits under the retirement program are accrued as expenses on
the books of the Adopting Funds. Such benefits are not secured or funded by the
Adopting Funds.


- ----------
(1)   An Eligible Trustee may elect alternative payments of his or her
      retirement benefits based upon the combined life expectancy of the
      Eligible Trustee and his or her spouse on the date of such Eligible
      Trustee's retirement. In addition, the Eligible Trustee may elect that
      the surviving spouse's periodic payment of benefits will be equal to a
      lower percentage of the periodic amount when both spouses were alive. The
      amount estimated to be payable under this method, through the remainder
      of the later of the lives of the Eligible Trustee and spouse, will be the
      actuarial equivalent of the Regular Benefit.


                                       21
<PAGE>

     The following table illustrates the retirement benefits accrued to the
Fund's Independent Trustees by the end for the fiscal year ended July 31, 1998
and by the 55 Morgan Stanley Dean Witter Funds (including the Fund) for the
year ended December 31, 1998, and the estimated retirement benefits for the
Independent Trustees, to commence upon their retirement, from the 55 Morgan
Stanley Dean Witter Funds as of December 31, 1998.


         RETIREMENT BENEFITS FROM ALL MORGAN STANLEY DEAN WITTER FUNDS




<TABLE>
<CAPTION>
                                    FOR ALL ADOPTING FUNDS                    ESTIMATED
                                -------------------------------  RETIREMENT     ANNUAL
                                   ESTIMATED                      BENEFITS     BENEFITS
                                    CREDITED                     ACCRUED AS      UPON
                                     YEARS         ESTIMATED      EXPENSES    RETIREMENT
                                 OF SERVICE AT   PERCENTAGE OF     BY ALL      FROM ALL
                                   RETIREMENT       ELIGIBLE      ADOPTING     ADOPTING
NAME OF INDEPENDENT TRUSTEE       (MAXIMUM 10)    COMPENSATION      FUNDS      FUNDS(2)
- ------------------------------- --------------- --------------- ------------ -----------
<S>                             <C>             <C>             <C>          <C>
Michael Bozic .................        10             60.44%       $22,377     $52,250
Edwin J. Garn .................        10             60.44         35,225      52,250
Wayne E. Hedien ...............         9             51.37         41,979      44,413
Dr. Manuel H. Johnson .........        10             60.44         14,047      52,250
Michael E. Nugent .............        10             60.44         25,336      52,250
John L. Schroeder .............         8             50.37         45,117      44,343
</TABLE>

- ----------

(2)   Based on current levels of compensation. Amount of annual benefits also
      varies depending on the Trustee's elections described in Footnote (1) on
      page 21.



IV. CONTROL PERSONS AND PRINCIPAL HOLDERS OF SECURITIES
- --------------------------------------------------------------------------------

     The following owned 5% or more of the outstanding Class A shares of the
Fund as of September 8, 1999: Morgan Stanley Dean Witter Trust FSB, Trustee,
Healthview Euro RSCG 401(k) Plan, P.O. box 957, Jersey City, NJ 07303-0957 --
13.11%; RPM 010 TRS of R.T. Nelson & Associates, Profit Sharing Plan DTD
03/01/88, FBO Ronald T. Nelson, 550 Keystone, River Forest, IL 60305-1612 --
6.69% and Jeffrey W. Andrews, 2025 Wimbeldon Lane, Union, KY 41091-9542 --
5.45%. The following owned 5% or more of the outstanding Class C shares of the
Fund as of September 8, 1999: John Stagliano, 626 Santa Monica Boulevard, Santa
Monica, CA 90401-2538 -- 11.16%. The following owned 5% or more of the
outstanding Class D shares of the Fund as of September 8, 1999: Morgan Stanley
Dean Witter Advisors Inc., Attn: Maurice Bendrihem, 2 World Trade Center, 70th
Floor, New York, NY 10048-0203 -- 34.19%; Dean Witter Reynolds Inc. ("DWR")
Custodian for George David Hanna Jr., IRA Rollover dated 08/09/91, 1400 Maple,
Newton, KS 67114-6309 -- 27.56%; DWR Custodian for Dr. Lawrence Tose, IRA STD
DTD 02/09/82, 39 High Street, Hingham, MA 02043-3191 -- 17.24%; MSDW Trust
Custodian IRA Rollover, Camilla M. Kim, 309 Ridgemoor Drive, Willowbrook, IL
60521-5416 -- 11.26% and DWR Custodian for Catherine C. Fawcett, IRA STD DTD
03/20/86, 606 Aredo de Carlos, Farmington, NM 87401-4063 -- 5.01%.


     As of the date of this Statement of Additional Information, the aggregate
number of shares of beneficial interest of the Fund owned by the Fund's
officers and Trustees as a group was less than 1% of the Fund's shares of
beneficial interest outstanding.


V. INVESTMENT MANAGEMENT AND OTHER SERVICES
- --------------------------------------------------------------------------------
A. INVESTMENT MANAGER

    The Investment Manager to the Fund is Morgan Stanley Dean Witter Advisors
Inc., a Delaware corporation, whose address is Two World Trade Center, New
York, New York 10048. The Investment Manager is a wholly-owned subsidiary of
MSDW, a Delaware corporation. MSDW is a preeminent global financial services
firm that maintains leading market positions in each of its three primary
businesses: securities, asset management and credit services.


                                       22
<PAGE>


     Pursuant to an Investment Management Agreement (the "Management
Agreement") with the Investment Manager, the Fund has retained the Investment
Manager to provide administrative services and manage the investment of the
Fund's assets, including the placing of orders for the purchase and sale of
portfolio securities. The Fund pays the Investment Manager monthly compensation
calculated daily by applying the following annual rates to the net assets of
the Fund determined as of the close of each business day: 1.00% to the portion
of daily net assets not exceeding $500 million; and 0.95% to the portion of the
daily net assets exceeding $500 million. The management fee is allocated among
the Classes pro rata based on the net assets of the Fund attributable to each
Class. For the fiscal years ended July 31, 1997, 1998 and 1999, the Investment
Manager accrued total compensation under the Management Agreement in the
amounts of $4,491,688, $4,024,502 and $3,320,393, respectively.


     The Investment Manager has retained its wholly-owned subsidiary, MSDW
Services Company, to perform administrative services for the Fund.


B. PRINCIPAL UNDERWRITER

     The Fund's principal underwriter is the Distributor (which has the same
address as the Investment Manager). In this capacity, the Fund's shares are
distributed by the Distributor. The Distributor has entered into a selected
dealer agreement with Dean Witter Reynolds, which through its own sales
organization sells shares of the Fund. In addition, the Distributor may enter
into similar agreements with other selected broker-dealers. The Distributor, a
Delaware corporation, is a wholly-owned subsidiary of MSDW.

     The Distributor bears all expenses it may incur in providing services
under the Distribution Agreement. These expenses include the payment of
commissions for sales of the Fund's shares and incentive compensation to
Financial Advisors. The Distributor also pays certain expenses in connection
with the distribution of the Fund's shares, including the costs of preparing,
printing and distributing advertising or promotional materials, and the costs
of printing and distributing prospectuses and supplements thereto used in
connection with the offering and sale of the Fund's shares. The Fund bears the
costs of initial typesetting, printing and distribution of prospectuses and
supplements thereto to shareholders. The Fund also bears the costs of
registering the Fund and its shares under federal and state securities laws and
pays filing fees in accordance with state securities laws.

     The Fund and the Distributor have agreed to indemnify each other against
certain liabilities, including liabilities under the Securities Act. Under the
Distribution Agreement, the Distributor uses its best efforts in rendering
services to the Fund, but in the absence of willful misfeasance, bad faith,
gross negligence or reckless disregard of its obligations, the Distributor is
not liable to the Fund or any of its shareholders for any error of judgment or
mistake of law or for any act or omission or for any losses sustained by the
Fund or its shareholders.


C. SERVICES PROVIDED BY THE INVESTMENT MANAGER AND FUND EXPENSES PAID BY THIRD
   PARTIES

     The Investment Manager manages the investment of the Fund's assets,
including the placing of orders for the purchase and sale of portfolio
securities. The Investment Manager obtains and evaluates the information and
advice relating to the economy, securities markets, and specific securities as
it considers necessary or useful to continuously manage the assets of the Fund
in a manner consistent with its investment objective.

     Under the terms of the Management Agreement, in addition to managing the
Fund's investments, the Investment Manager maintains certain of the Fund's
books and records and furnishes, at its own expense, the office space,
facilities, equipment, clerical help, bookkeeping and certain legal services as
the Fund may reasonably require in the conduct of its business, including the
preparation of prospectuses, proxy statements and reports required to be filed
with federal and state securities commissions (except insofar as the
participation or assistance of independent accountants and attorneys is, in the
opinion of the Investment Manager, necessary or desirable). In addition, the
Investment Manager pays the salaries of all personnel, including officers of
the Fund, who are employees of the Investment Manager. The Investment Manager
also bears the cost of telephone service, heat, light, power and other
utilities provided to the Fund.


                                       23
<PAGE>

     Expenses not expressly assumed by the Investment Manager under the
Management Agreement or by the Distributor, will be paid by the Fund. These
expenses will be allocated among the four Classes of shares pro rata based on
the net assets of the Fund attributable to each Class, except as described
below. Such expenses include, but are not limited to: expenses of the Plan of
Distribution pursuant to Rule 12b-1; charges and expenses of any registrar,
custodian, stock transfer and dividend disbursing agent; brokerage commissions;
taxes; engraving and printing share certificates; registration costs of the
Fund and its shares under federal and state securities laws; the cost and
expense of printing, including typesetting, and distributing prospectuses of
the Fund and supplements thereto to the Fund's shareholders; all expenses of
shareholders' and Trustees' meetings and of preparing, printing and mailing of
proxy statements and reports to shareholders; fees and travel expenses of
Trustees or members of any advisory board or committee who are not employees of
the Investment Manager or any corporate affiliate of the Investment Manager;
all expenses incident to any dividend, withdrawal or redemption options;
charges and expenses of any outside service used for pricing of the Fund's
shares; fees and expenses of legal counsel, including counsel to the Trustees
who are not interested persons of the Fund or of the Investment Manager (not
including compensation or expenses of attorneys who are employees of the
Investment Manager); fees and expenses of the Fund's independent accountants;
membership dues of industry associations; interest on Fund borrowings; postage;
insurance premiums on property or personnel (including officers and Trustees)
of the Fund which inure to its benefit; extraordinary expenses (including, but
not limited to, legal claims and liabilities and litigation costs and any
indemnification relating thereto); and all other costs of the Fund's operation.
The 12b-1 fees relating to a particular Class will be allocated directly to
that Class. In addition, other expenses associated with a particular Class
(except advisory or custodial fees) may be allocated directly to that Class,
provided that such expenses are reasonably identified as specifically
attributable to that Class and the direct allocation to that Class is approved
by the Trustees.


     The Management Agreement provides that in the absence of willful
misfeasance, bad faith, gross negligence or reckless disregard of its
obligations thereunder, the Investment Manager is not liable to the Fund or any
of its investors for any act or omission by the Investment Manager or for any
losses sustained by the Fund or its investors.


     The Management Agreement will remain in effect from year to year, provided
continuance of the Management Agreement is approved at least annually by the
vote of the holders of a majority, as defined in the Investment Company Act, of
the outstanding shares of the Fund, or by the Trustees; provided that in either
event such continuance is approved annually by the vote of a majority of the
Trustees.


D. DEALER REALLOWANCES


     Upon notice to selected broker-dealers, the Distributor may reallow up to
the full applicable front-end sales charge during periods specified in such
notice. During periods when 90% or more of the sales charge is reallowed, such
selected broker-dealers may be deemed to be underwriters as that term is
defined in the Securities Act.


E. RULE 12B-1 PLAN


     The Fund has adopted a Plan of Distribution pursuant to Rule 12b-1 under
the Investment Company Act (the "Plan") pursuant to which each Class, other
than Class D, pays the Distributor compensation accrued daily and payable
monthly at the following annual rates: 0.25% and 1.0% of the average daily net
assets of Class A and Class C, respectively, and, with respect to Class B, 1.0%
of the lesser of: (a) the average daily aggregate gross sales of the Fund's
Class B shares since the inception of the Fund (not including reinvestments of
dividends or capital gains distributions), less the average daily aggregate net
asset value of the Fund's Class B shares redeemed since the Fund's inception
upon which a contingent deferred sales charge has been imposed or upon which
such charge has been waived; or (b) the average daily net assets of Class B.


                                       24
<PAGE>

     The Distributor also receives the proceeds of front-end sales charges
("FSCs") and of contingent deferred sales charges ("CDSCs") imposed on certain
redemptions of shares, which are separate and apart from payments made pursuant
to the Plan. The Distributor has informed the Fund that it and/or Dean Witter
Reynolds received the proceeds of CDSCs and FSCs, for the last three fiscal
years ended July 31, in approximate amounts as provided in the table below (the
Distributor did not retain any of these amounts).





<TABLE>
<CAPTION>
                               1999                      1998                       1997
                     ------------------------   ----------------------   ---------------------------
<S>                  <C>          <C>           <C>        <C>           <C>        <C>
Class A ..........   FSCs:(1)     $  9,271      FSCs:      $  4,691      FSCs:         $        0(2)
                     CDSCs:       $    262      CDSCs:     $      0      CDSCs:                 0(2)
Class B ..........   CDSCs:       $510,447      CDSCs:     $944,044      CDSCs:        $1,142,039
Class C ..........   CDSCs:       $  2,103      CDSCs:     $    249      CDSCs:                 0(2)
</TABLE>


- ----------
(1)   FSCs apply to Class A only.

(2)   This Class commenced operations on July 28, 1997.


     The Distributor has informed the Fund that the entire fee payable by Class
A and a portion of the fees payable by each of Class B and Class C each year
pursuant to the Plan equal to 0.25% of such Class' average daily net assets are
currently each characterized as a "service fee" under the Rules of the National
Association of Securities Dealers, Inc. (of which the Distributor is a member).
The "service fee" is a payment made for personal service and/or the maintenance
of shareholder accounts. The remaining portion of the Plan fees payable by a
Class, if any, is characterized as an "asset-based sales charge" as such is
defined by the Rules of the Association.


     Under the Plan and as required by Rule 12b-1, the Trustees receive and
review promptly after the end of each calendar quarter a written report
provided by the Distributor of the amounts expended under the Plan and the
purpose for which such expenditures were made. For the fiscal year ended July
31, 1999, Class B shares of the Fund accrued amounts payable to the Distributor
under the Plan of $3,292,077. This amount is equal to 1.00% of the average
daily net assets of Class B and was calculated pursuant to Clause (b) of the
compensation formula under the Plan. For the fiscal year ended July 31, 1999,
Class A and Class C shares of the Fund accrued payments under the Plan
amounting to $1,354 and $10,873, respectively, which amounts are equal to 0.20%
and 1.00% of the average daily net assets of Class A and Class C, respectively,
for the fiscal year.


     The Plan was adopted in order to permit the implementation of the Fund's
method of distribution. Under this distribution method the Fund offers four
Classes, each with a different distribution arrangement.

     With respect to Class A shares, Dean Witter Reynolds compensates its
Financial Advisors by paying them, from proceeds of the FSC, commissions for
the sale of Class A shares, currently a gross sales credit of up to 5.0% of the
amount sold (except as provided in the following sentence) and an annual
residual commission, currently a residual of up to 0.25% of the current value
of the respective accounts for which they are the Financial Advisors or dealers
of record in all cases. On orders of $1 million or more (for which no sales
charge was paid) or net asset value purchases by employer-sponsored employee
benefit plans, whether or not qualified under the Internal Revenue Code, for
which the Transfer Agent serves as Trustee or Dean Witter Reynolds Retirement
Plan Services serves as recordkeeper pursuant to a written Recordkeeping
Services Agreement ("MSDW Eligible Plans"), the Investment Manager compensates
Financial Advisors by paying them, from its own funds, a gross sales credit of
1.0% of the amount sold.

     With respect to Class B shares, Dean Witter Reynolds compensates its
Financial Advisors by paying them, from its own funds, commissions for the sale
of Class B shares, currently a gross sales credit of up to 5.0% of the amount
sold (except as provided in the following sentence) and an annual residual
commission, currently a residual of up to 0.25% of the current value (not
including reinvested dividends


                                       25
<PAGE>

or distributions) of the amount sold in all cases. In the case of Class B
shares purchased by MSDW Eligible Plans, Dean Witter Reynolds compensates its
Financial Advisors by paying them, from its own funds, a gross sales credit of
3.0% of the amount sold.

     With respect to Class C shares, Dean Witter Reynolds compensates its
Financial Advisors by paying them, from its own funds, commissions for the sale
of Class C shares, currently a gross sales credit of up to 1.0% of the amount
sold and an annual residual commission, currently up to 1.0% of the current
value of the respective accounts for which they are the Financial Advisors of
record.

     With respect to Class D shares other than shares held by participants in
the Investment Manager's mutual fund asset allocation program, the Investment
Manager compensates Dean Witter Reynolds's Financial Advisors by paying them,
from its own funds, commissions for the sale of Class D shares, currently a
gross sales credit of up to 1.0% of the amount sold. There is a chargeback of
100% of the amount paid if the Class D shares are redeemed in the first year
and a chargeback of 50% of the amount paid if the Class D shares are redeemed
in the second year after purchase. The Investment Manager also compensates Dean
Witter Reynolds's Financial Advisors by paying them, from its own funds, an
annual residual commission, currently up to 0.10% of the current value of the
respective accounts for which they are the Financial Advisors of record (not
including accounts of participants in the Investment Manager's mutual fund
asset allocation program).

     The gross sales credit is a charge which reflects commissions paid by Dean
Witter Reynolds to its Financial Advisors and Dean Witter Reynolds's
Fund-associated distribution-related expenses, including sales compensation,
and overhead and other branch office distribution-related expenses including
(a) the expenses of operating Dean Witter Reynolds's branch offices in
connection with the sale of Fund shares, including lease costs, the salaries
and employee benefits of operations and sales support personnel, utility costs,
communications costs and the costs of stationery and supplies, (b) the costs of
client sales seminars, (c) travel expenses of mutual fund sales coordinators to
promote the sale of Fund shares and (d) other expenses relating to branch
promotion of Fund sales.

     The distribution fee that the Distributor receives from the Fund under the
Plan, in effect, offsets distribution expenses incurred under the Plan on
behalf of the Fund and, in the case of Class B shares, opportunity costs, such
as the gross sales credit and an assumed interest charge thereon ("carrying
charge"). In the Distributor's reporting of the distribution expenses to the
Fund, in the case of Class B shares, such assumed interest (computed at the
"broker's call rate") has been calculated on the gross credit as it is reduced
by amounts received by the Distributor under the Plan and any contingent
deferred sales charges received by the Distributor upon redemption of shares of
the Fund. No other interest charge is included as a distribution expense in the
Distributor's calculation of its distribution costs for this purpose. The
broker's call rate is the interest rate charged to securities brokers on loans
secured by exchange-listed securities.

     The Fund is authorized to reimburse expenses incurred or to be incurred in
promoting the distribution of the Fund's Class A and Class C shares and in
servicing shareholder accounts. Reimbursement will be made through payments at
the end of each month. The amount of each monthly payment may in no event
exceed an amount equal to a payment at the annual rate of 0.25%, in the case of
Class A, and 1.0%, in the case of Class C, of the average net assets of the
respective Class during the month. No interest or other financing charges, if
any, incurred on any distribution expenses on behalf of Class A and Class C
will be reimbursable under the Plan. With respect to Class A, in the case of
all expenses other than expenses representing the service fee, and, with
respect to Class C, in the case of all expenses other than expenses
representing a gross sales credit or a residual to Financial Advisors and other
authorized financial representatives, such amounts shall be determined at the
beginning of each calendar quarter by the Trustees, including, a majority of
the Independent Trustees. Expenses representing the service fee (for Class A)
or a gross sales credit or a residual to Financial Advisors and other
authorized financial representatives (for Class C) may be reimbursed without
prior determination. In the event that the Distributor proposes that monies
shall be reimbursed for other than such expenses, then in making quarterly
determinations of the amounts that may be reimbursed by the Fund, the
Distributor will provide and the Trustees will review a quarterly budget of
projected distribution expenses


                                       26
<PAGE>

to be incurred on behalf of the Fund, together with a report explaining the
purposes and anticipated benefits of incurring such expenses. The Trustees will
determine which particular expenses, and the portions thereof, that may be
borne by the Fund, and in making such a determination shall consider the scope
of the Distributor's commitment to promoting the distribution of the Fund's
Class A and Class C shares.


     Each Class paid 100% of the amounts accrued under the Plan with respect to
that Class for the fiscal year ended July 31, 1999 to the Distributor. The
Distributor and Dean Witter Reynolds estimate that they have spent, pursuant to
the Plan, $40,272,783 on behalf of Class B since the inception of the Plan. It
is estimated that this amount was spent in approximately the following ways:
(i) 11.13% ($4,482,392) -- advertising and promotional expenses; (ii) 0.70%
($281,222) -- printing of prospectuses for distribution to other than current
shareholders; and (iii) 88.17% ($35,509,169) -- other expenses, including the
gross sales credit and the carrying charge, of which 9.50% ($3,374,570)
represents carrying charges, 37.47% ($13,303,724) represents commission credits
to Dean Witter Reynolds branch offices and other selected broker-dealers for
payments of commissions to Financial Advisors and other authorized financial
representatives, and 53.03% ($18,830,875) represents overhead and other branch
office distribution-related expenses. The amounts accrued by Class A and a
portion of the amounts accrued by Class C under the Plan during the fiscal year
ended July 31, 1999 were service fees. The remainder of the amounts accrued by
Class C were for expenses which relate to compensation of sales personnel and
associated overhead expenses.

     In the case of Class B shares, at any given time, the expenses of
distributing shares of the Fund may be more or less than the total of (i) the
payments made by the Fund pursuant to the Plan; and (ii) the proceeds of CDSCs
paid by investors upon redemption of shares. For example, if $1 million in
expenses in distributing Class B shares of the Fund had been incurred and
$750,000 had been received as described in (i) and (ii) above, the excess
expense would amount to $250,000. The Distributor has advised the Fund that in
the case of Class B shares the excess distribution expenses, including the
carrying charge designed to approximate the opportunity costs incurred by Dean
Witter Reynolds which arise from it having advanced monies without having
received the amount of any sales charges imposed at the time of sale of the
Fund's Class B shares, totaled $12,500,579 as of July 31, 1999 (the end of the
Fund's fiscal year), which was equal to 4.23% of the net assets of Class B on
such date. Because there is no requirement under the Plan that the Distributor
be reimbursed for all distribution expenses with respect to Class B shares or
any requirement that the Plan be continued from year to year, this excess
amount does not constitute a liability of the Fund. Although there is no legal
obligation for the Fund to pay expenses incurred in excess of payments made to
the Distributor under the Plan and the proceeds of CDSCs paid by investors upon
redemption of shares, if for any reason the Plan is terminated, the Trustees
will consider at that time the manner in which to treat such expenses. Any
cumulative expenses incurred, but not yet recovered through distribution fees
or CDSCs, may or may not be recovered through future distribution fees or
CDSCs.

     In the case of Class A and Class C shares, expenses incurred pursuant to
the Plan in any calendar year in excess of 0.25% or 1.0% of the average daily
net assets of Class A or Class C, respectively, will not be reimbursed by the
Fund through payments in any subsequent year, except that expenses representing
a gross sales commission credited to Morgan Stanley Dean Witter Financial
Advisors and other authorized financial representatives at the time of sale may
be reimbursed in the subsequent calendar year. The Distributor has advised the
Fund that unreimbursed expenses representing a gross sales commission credited
to Morgan Stanley Dean Witter Financial Advisors and other authorized financial
representatives at the time of sale totaled $3,945 in the case of Class C at
December 31, 1998 (end of the calendar year), which amount was equal to 0.37%
of the net assets of Class C on such date, and that there were no such expenses
that may be reimbursed in the subsequent year in the case of Class A on such
date. No interest or other financing charges will be incurred on any Class A or
Class C distribution expenses incurred by the Distributor under the Plan or on
any unreimbursed expenses due to the Distributor pursuant to the Plan.


     No interested person of the Fund nor any Independent Trustee has any
direct financial interest in the operation of the Plan except to the extent
that the Distributor, the Investment Manager, Dean Witter


                                       27
<PAGE>

Reynolds, MSDW Services Company or certain of their employees may be deemed to
have such an interest as a result of benefits derived from the successful
operation of the Plan or as a result of receiving a portion of the amounts
expended thereunder by the Fund.

     On an annual basis, the Trustees, including a majority of the Independent
Trustees, consider whether the Plan should be continued. Prior to approving the
last continuation of the Plan, the Trustees requested and received from the
Distributor and reviewed all the information which they deemed necessary to
arrive at an informed determination. In making their determination to continue
the Plan, the Trustees considered: (1) the Fund's experience under the Plan and
whether such experience indicates that the Plan is operating as anticipated;
(2) the benefits the Fund had obtained, was obtaining and would be likely to
obtain under the Plan, including that: (a) the Plan is essential in order to
give Fund investors a choice of alternatives for payment of distribution and
service charges and to enable the Fund to continue to grow and avoid a pattern
of net redemptions which, in turn, are essential for effective investment
management; and (b) without the compensation to individual brokers and the
reimbursement of distribution and account maintenance expenses of Dean Witter
Reynolds's branch offices made possible by the 12b-1 fees, Dean Witter Reynolds
could not establish and maintain an effective system for distribution,
servicing of Fund shareholders and maintenance of shareholder accounts; and (3)
what services had been provided and were continuing to be provided under the
Plan to the Fund and its shareholders. Based upon their review, the Trustees,
including each of the Independent Trustees, determined that continuation of the
Plan would be in the best interest of the Fund and would have a reasonable
likelihood of continuing to benefit the Fund and its shareholders. In the
Trustees' quarterly review of the Plan, they will consider its continued
appropriateness and the level of compensation provided therein.

     The Plan may not be amended to increase materially the amount to be spent
for the services described therein without approval by the shareholders of the
affected Class or Classes of the Fund, and all material amendments to the Plan
must also be approved by the Trustees in the manner described above. The Plan
may be terminated at any time, without payment of any penalty, by vote of a
majority of the Independent Trustees or by a vote of a majority of the
outstanding voting securities of the Fund (as defined in the Investment Company
Act) on not more than thirty days' written notice to any other party to the
Plan. So long as the Plan is in effect, the election and nomination of
Independent Trustees shall be committed to the discretion of the Independent
Trustees.


F. OTHER SERVICE PROVIDERS


(1) TRANSFER AGENT/DIVIDEND-PAYING AGENT

     Morgan Stanley Dean Witter Trust FSB is the Transfer Agent for the Fund's
shares and the Dividend Disbursing Agent for payment of dividends and
distributions on Fund shares and Agent for shareholders under various
investment plans. The principal business address of the Transfer Agent is
Harborside Financial Center, Plaza Two, Jersey City, New Jersey 07311.


(2) CUSTODIAN AND INDEPENDENT ACCOUNTANTS

     The Bank of New York, 90 Washington Street, New York, NY 10286, is the
Custodian of the Fund's assets. Any of the Fund's cash balances with the
Custodian in excess of $100,000 are unprotected by federal deposit insurance.
These balances may, at times, be substantial.


     PricewaterhouseCoopers LLP, 1177 Avenue of the Americas, New York, NY
10036, serves as the independent accountants of the Fund. The independent
accountants are responsible for auditing the annual financial statements of the
Fund.



(3) AFFILIATED PERSONS

     The Transfer Agent is an affiliate of the Investment Manager, and of the
Distributor. As Transfer Agent and Dividend Disbursing Agent, the Transfer
Agent's responsibilities include maintaining shareholder accounts, disbursing
cash dividends and reinvesting dividends, processing account registration


                                       28
<PAGE>

changes, handling purchase and redemption transactions, mailing prospectuses
and reports, mailing and tabulating proxies, processing share certificate
transactions, and maintaining shareholder records and lists. For these
services, the Transfer Agent receives a per shareholder account fee from the
Fund and is reimbursed for its out-of-pocket expenses in connection with such
services.


VI. BROKERAGE ALLOCATION AND OTHER PRACTICES
- --------------------------------------------------------------------------------
A. BROKERAGE TRANSACTIONS


     Subject to the general supervision of the Trustees, the Investment Manager
is responsible for decisions to buy and sell securities for the Fund, the
selection of brokers and dealers to effect the transactions, and the
negotiation of brokerage commissions, if any. Purchases and sales of securities
on a stock exchange are effected through brokers who charge a commission for
their services. In the over-the-counter market, securities are generally traded
on a "net" basis with dealers acting as principal for their own accounts
without a stated commission, although the price of the security usually
includes a profit to the dealer. The Fund also expects that securities will be
purchased at times in underwritten offerings where the price includes a fixed
amount of compensation, generally referred to as the underwriter's concession
or discount. Options and futures transactions will usually be effected through
a broker and a commission will be charged. On occasion, the Fund may also
purchase certain money market instruments directly from an issuer, in which
case no commissions or discounts are paid.


     For the fiscal years ended July 31, 1997, 1998 and 1999, the Fund paid a
total of $503,093, $782,678 and $880,347, respectively, in brokerage
commissions.




B. COMMISSIONS

     Pursuant to an order of the SEC, the Fund may effect principal
transactions in certain money market instruments with Dean Witter Reynolds. The
Fund will limit its transactions with Dean Witter Reynolds to U.S. Government
and government agency securities, bank money instruments (i.e., certificates of
deposit and bankers' acceptances) and commercial paper. The transactions will
be effected with Dean Witter Reynolds only when the price available from Dean
Witter Reynolds is better than that available from other dealers.

     During the fiscal years ended July 31, 1997, 1998 and 1999, the Fund did
not effect any principal transactions with Dean Witter Reynolds.

     Brokerage transactions in securities listed on exchanges or admitted to
unlisted trading privileges may be effected through Dean Witter Reynolds,
Morgan Stanley & Co. and other affiliated brokers and dealers. In order for an
affiliated broker or dealer to effect any portfolio transactions on an exchange
for the Fund, the commissions, fees or other remuneration received by the
affiliated broker or dealer must be reasonable and fair compared to the
commissions, fees or other remuneration paid to other brokers in connection
with comparable transactions involving similar securities being purchased or
sold on an exchange during a comparable period of time. This standard would
allow the affiliated broker or dealer to receive no more than the remuneration
which would be expected to be received by an unaffiliated broker in a
commensurate arm's-length transaction. Furthermore, the Trustees, including the
Independent Trustees, have adopted procedures which are reasonably designed to
provide that any commissions, fees or other remuneration paid to an affiliated
broker or dealer are consistent with the foregoing standard. The Fund does not
reduce the management fee it pays to the Investment Manager by any amount of
the brokerage commissions it may pay to an affiliated broker or dealer.


     During the fiscal years ended July 31, 1997, 1998 and 1999, the Fund paid
a total of $10,330, $38,725 and $213,176, respectively, in brokerage
commissions to Dean Witter Reynolds. During the fiscal year ended July 31,
1999, the brokerage commissions paid to Dean Witter Reynolds represented
approximately 24.21% of the total brokerage commissions paid by the Fund during
the year and were paid on account of transactions having an aggregate dollar
value equal to approximately 30.83% of the aggregate dollar value of all
portfolio transactions of the Fund during the year for which commissions were
paid.



                                       29
<PAGE>


     During the period June 1, 1997 through July 31, 1997 and during the fiscal
years ended July 31, 1998 and 1999, the Fund paid a total of $0, $33,730 and
$37,760, respectively, in brokerage commissions to Morgan Stanley & Co., which
broker-dealer became an affiliate of the Investment Manager on May 31, 1997
upon consummation of the merger of Dean Witter, Discover & Co. with Morgan
Stanley Group Inc. During the fiscal year ended July 31, 1999, the brokerage
commissions paid to Morgan Stanley & Co. represented approximately 4.29% of the
total brokerage commissions paid by the Fund for this period and were paid on
account of transactions having an aggregate dollar value equal to approximately
4.59% of the aggregate dollar value of all portfolio transactions of the Fund
during the year for which commissions were paid.



C. BROKERAGE SELECTION

     The policy of the Fund regarding purchases and sales of securities for its
portfolio is that primary consideration will be given to obtaining the most
favorable prices and efficient executions of transactions. Consistent with this
policy, when securities transactions are effected on a stock exchange, the
Fund's policy is to pay commissions which are considered fair and reasonable
without necessarily determining that the lowest possible commissions are paid
in all circumstances. The Fund believes that a requirement always to seek the
lowest possible commission cost could impede effective portfolio management and
preclude the Fund and the Investment Manager from obtaining a high quality of
brokerage and research services. In seeking to determine the reasonableness of
brokerage commissions paid in any transaction, the Investment Manager relies
upon its experience and knowledge regarding commissions generally charged by
various brokers and on its judgment in evaluating the brokerage and research
services received from the broker effecting the transaction. These
determinations are necessarily subjective and imprecise, as in most cases an
exact dollar value for those services is not ascertainable.

     The Fund anticipates that certain of its transactions involving foreign
securities will be effected on foreign securities exchanges. Fixed commissions
on such transactions are generally higher than negotiated commissions on
domestic transactions. There is also generally less government supervision and
regulation of foreign securities exchanges and brokers than in the United
States.

     In seeking to implement the Fund's policies, the Investment Manager
effects transactions with those brokers and dealers who the Investment Manager
believes provide the most favorable prices and are capable of providing
efficient executions. If the Investment Manager believes the prices and
executions are obtainable from more than one broker or dealer, it may give
consideration to placing portfolio transactions with those brokers and dealers
who also furnish research and other services to the Fund or the Investment
Manager. The services may include, but are not limited to, any one or more of
the following: information as to the availability of securities for purchase or
sale; statistical or factual information or opinions pertaining to investment;
wire services; and appraisals or evaluations of portfolio securities. The
information and services received by the Investment Manager from brokers and
dealers may be of benefit to the Investment Manager in the management of
accounts of some of its other clients and may not in all cases benefit the Fund
directly.

     The Investment Manager currently serves as investment manager to a number
of clients, including other investment companies, and may in the future act as
investment manager or advisor to others. It is the practice of the Investment
Manager to cause purchase and sale transactions to be allocated among the Fund
and others whose assets it manages in such manner as it deems equitable. In
making such allocations among the Fund and other client accounts, various
factors may be considered, including the respective investment objectives, the
relative size of portfolio holdings of the same or comparable securities, the
availability of cash for investment, the size of investment commitments
generally held and the opinions of the persons responsible for managing the
portfolios of the Fund and other client accounts. In the case of certain
initial and secondary public offerings, the Investment Manager may utilize a
pro rata allocation process based on the size of the Morgan Stanley Dean Witter
Funds involved and the number of shares available from the public offering.


                                       30
<PAGE>

D. DIRECTED BROKERAGE


     During the fiscal year ended July 31, 1999, the Fund paid $620,511 in
brokerage commissions in connection with transactions in the aggregate amount
of $441,134,326 to brokers because of research services provided.



E. REGULAR BROKER-DEALERS

     During the fiscal year ended July 31, 1999, the Fund did not purchase
securities issued by brokers or dealers that were among the ten brokers or ten
dealers which executed transactions for or with the Fund in the largest dollar
amounts during the period. At July 31, 1999, the Fund did not own any
securities issued by any such issuers.


VII. CAPITAL STOCK AND OTHER SECURITIES
- --------------------------------------------------------------------------------
     The shareholders of the Fund are entitled to a full vote for each full
share of beneficial interest held. The Fund is authorized to issue an unlimited
number of shares of beneficial interest. All shares of beneficial interest of
the Fund are of $0.01 par value and are equal as to earnings, assets and voting
privileges except that each Class will have exclusive voting privileges with
respect to matters relating to distribution expenses borne solely by such Class
or any other matter in which the interests of one Class differ from the
interests of any other Class. In addition, Class B shareholders will have the
right to vote on any proposed material increase in Class A's expenses, if such
proposal is submitted separately to Class A shareholders. Also, Class A, Class
B and Class C bear expenses related to the distribution of their respective
shares.

     The Fund's Declaration of Trust permits the Trustees to authorize the
creation of additional series of shares (the proceeds of which would be
invested in separate, independently managed portfolios) and additional Classes
of shares within any series. The Trustees have not presently authorized any
such additional series or Classes of shares other than as set forth in the
Prospectus.


     The Fund is not required to hold annual meetings of shareholders and in
ordinary circumstances the Fund does not intend to hold such meetings. The
Trustees may call special meetings of shareholders for action by shareholder
vote as may be required by the Investment Company Act or the Declaration of
Trust. Under certain circumstances, the Trustees may be removed by the actions
of the Trustees. In addition, under certain circumstances, the shareholders may
call a meeting to remove the Trustees and the Fund is required to provide
assistance in communicating with shareholders about such a meeting. The voting
rights of shareholders are not cumulative, so that holders of more than 50
percent of the shares voting can, if they choose, elect all Trustees being
selected, while the holders of the remaining shares would be unable to elect
any Trustees.


     Under Massachusetts law, shareholders of a business trust may, under
certain limited circumstances, be held personally liable as partners for the
obligations of the Fund. However, the Declaration of Trust contains an express
disclaimer of shareholder liability for acts or obligations of the Fund,
requires that notice of such Fund obligations include such disclaimer, and
provides for indemnification out of the Fund's property for any shareholder
held personally liable for the obligations of the Fund. Thus, the risk of a
shareholder incurring financial loss on account of shareholder liability is
limited to circumstances in which the Fund itself would be unable to meet its
obligations. Given the above limitations on shareholder personal liability, and
the nature of the Fund's assets and operations, the possibility of the Fund
being unable to meet its obligations is remote and thus, in the opinion of
Massachusetts counsel to the Fund, the risk to Fund shareholders of personal
liability is remote.


     All of the Trustees have been elected by the shareholders of the Fund,
most recently at a Special Meeting of Shareholders held on May 21, 1997. The
Trustees themselves have the power to alter the number and the terms of office
of the Trustees (as provided for in the Declaration of Trust), and they may at
any time lengthen or shorten their own terms or make their terms of unlimited
duration and appoint their own successors, provided that always at least a
majority of the Trustees has been elected by the shareholders of the Fund.



                                       31
<PAGE>

VIII. PURCHASE, REDEMPTION AND PRICING OF SHARES
- --------------------------------------------------------------------------------
A. PURCHASE/REDEMPTION OF SHARES


     Information concerning how Fund shares are offered to the public (and how
they are redeemed and exchanged) is provided in the Fund's Prospectus.

     TRANSFER AGENT AS AGENT. With respect to the redemption or repurchase of
Fund shares, the application of proceeds to the purchase of new shares in the
Fund or any other Morgan Stanley Dean Witter Funds and the general
administration of the exchange privilege, the Transfer Agent acts as agent for
the Distributor and for the shareholder's authorized broker-dealer, if any, in
the performance of such functions. With respect to exchanges, redemptions or
repurchases, the Transfer Agent shall be liable for its own negligence and not
for the default or negligence of its correspondents or for losses in transit.
The Fund shall not be liable for any default or negligence of the Transfer
Agent, the Distributor or any authorized broker-dealer.

     The Distributor and any authorized broker-dealer have appointed the
Transfer Agent to act as their agent in connection with the application of
proceeds of any redemption of Fund shares to the purchase of shares of any
other Morgan Stanley Dean Witter Fund and the general administration of the
exchange privilege. No commission or discounts will be paid to the Distributor
or any authorized broker-dealer for any transaction pursuant to the exchange
privilege.

     TRANSFERS OF SHARES. In the event a shareholder requests a transfer of
Fund shares to a new registration, the shares will be transferred without sales
charge at the time of transfer. With regard to the status of shares which are
either subject to the CDSC or free of such charge (and with regard to the
length of time shares subject to the charge have been held), any transfer
involving less than all of the shares in an account will be made on a pro rata
basis (that is, by transferring shares in the same proportion that the
transferred shares bear to the total shares in the account immediately prior to
the transfer). The transferred shares will continue to be subject to any
applicable CDSC as if they had not been so transferred.


B. OFFERING PRICE

     The Fund's Class B, Class C and Class D shares are offered at net asset
value per share and the Class A shares are offered at net asset value per share
plus any applicable FSC which is distributed among the Fund's Distributor, Dean
Witter Reynolds and other authorized dealers as described in Section "V.
Investment Management and Other Services -- E. Rule 12b-1 Plan." The price of
Fund shares, called "net asset value," is based on the value of the Fund's
portfolio securities. Net asset value per share of each Class is calculated by
dividing the value of the portion of the Fund's securities and other assets
attributable to that Class, less the liabilities attributable to that Class, by
the number of shares of that Class outstanding. The assets of each Class of
shares are invested in a single portfolio. The net asset value of each Class,
however, will differ because the Classes have different ongoing fees.

     In the calculation of the Fund's net asset value: (1) an equity portfolio
security listed or traded on the New York or American Stock Exchange or other
stock exchange is valued at its latest sale price on that exchange, prior to
the time when assets are valued; if there were no sales that day, the security
is valued at the latest bid price (in cases where a security is traded on more
than one exchange, the security is valued on the exchange designated as the
primary market pursuant to procedures adopted by the Trustees); and (2) all
other portfolio securities for which over-the-counter market quotations are
readily available are valued at the latest bid price. When market quotations
are not readily available, including circumstances under which it is determined
by the Investment Manager that sale or bid prices are not reflective of a
security's market value, portfolio securities are valued at their fair value as
determined in good faith under procedures established by and under the general
supervision of the Fund's Trustees. For valuation purposes, quotations of
foreign portfolio securities, other assets and liabilities and forward
contracts stated in foreign currency are translated into U.S. dollar
equivalents at the prevailing market rates prior to the close of the New York
Stock Exchange.


                                       32
<PAGE>

     Short-term debt securities with remaining maturities of sixty days or less
at the time of purchase are valued at amortized cost, unless the Trustees
determine such does not reflect the securities' market value, in which case
these securities will be valued at their fair value as determined by the
Trustees.

     Certain of the Fund's portfolio securities may be valued by an outside
pricing service approved by the Fund's Trustees. The pricing service may
utilize a matrix system incorporating security quality, maturity and coupon as
the evaluation model parameters, and/or research evaluations by its staff,
including review of broker-dealer market price quotations in determining what
it believes is the fair valuation of the portfolio securities valued by such
pricing service.

     Listed options on debt securities are valued at the latest sale price on
the exchange on which they are listed unless no sales of such options have
taken place that day, in which case they will be valued at the mean between
their latest bid and asked prices. Unlisted options on debt securities and all
options on equity securities are valued at the mean between their latest bid
and asked prices. Futures are valued at the latest sale price on the
commodities exchange on which they trade unless the Trustees determine such
price does not reflect their market value, in which case they will be valued at
their fair value as determined in good faith under procedures established by
and under the supervision of the Trustees.

     Generally, trading in foreign securities, as well as corporate bonds, U.S.
Government securities and money market instruments, is substantially completed
each day at various times prior to the close of the New York Stock Exchange.
The values of such securities used in computing the net asset value of the
Fund's shares are determined as of such times. Foreign currency exchange rates
are also generally determined prior to the close of the New York Stock
Exchange. Occasionally, events which may affect the values of such securities
and such exchange rates may occur between the times at which they are
determined and the close of the New York Stock Exchange and will therefore not
be reflected in the computation of the Fund's net asset value. If events that
may affect the value of such securities occur during such period, then these
securities may be valued at their fair value as determined in good faith under
procedures established by and under the supervision of the Trustees.


IX. TAXATION OF THE FUND AND SHAREHOLDERS
- --------------------------------------------------------------------------------
     The Fund generally will make two basic types of distributions: ordinary
dividends and long-term capital gain distributions. These two types of
distributions are reported differently on a shareholder's income tax return and
they are also subject to different rates of tax. The tax treatment of the
investment activities of the Fund will affect the amount and timing and
character of the distributions made by the Fund. Tax issues relating to the
Fund are not generally a consideration for shareholders such as tax exempt
entities and tax-advantaged retirement vehicles such as an IRA or 401(k) plan.
Shareholders are urged to consult their own tax professionals regarding
specific questions as to federal, state or local taxes.

     INVESTMENT COMPANY TAXATION. The Fund intends to remain qualified as a
regulated investment company under Subchapter M of the Internal Revenue Code of
1986. As such, the Fund will not be subject to federal income tax on its net
investment income and capital gains, if any, to the extent that it distributes
such income and capital gains to its shareholders.

     The Fund generally intends to distribute sufficient income and gains so
that the Fund will not pay corporate income tax on its earnings. The Fund also
generally intends to distribute to its shareholders in each calendar year a
sufficient amount of ordinary income and capital gains to avoid the imposition
of a 4% excise tax. However, the Fund may instead determine to retain all or
part of any net long-term capital gains in any year for reinvestment. In such
event, the Fund will pay federal income tax (and possibly excise tax) on such
retained gains.

     Gains or losses on sales of securities by the Fund will be long-term
capital gains or losses if the securities have a tax holding period of more
than one year. Gains or losses on the sale of securities with a tax holding
period of one year or less will be short-term gains or losses.

     Gains or losses on the Fund's transactions in listed non-equity options,
futures and options on futures generally are treated as 60% long-term and 40%
short-term. When the Fund engages in options


                                       33
<PAGE>

and futures transactions, various tax rules may accelerate or defer recognition
of certain gains and losses, change the character of certain gains or losses,
or alter the holding period of other investments held by the Fund. The
application of these rules would therefore also affect the amount, timing and
character of distributions made by the Fund.

     Under certain tax rules, the Fund may be required to accrue a portion of
any discount at which certain securities are purchased as income each year even
though the Fund receives no payments in cash on the security during the year.
To the extent that the Fund invests in such securities, it would be required to
pay out such accrued discount as an income distribution in each year in order
to avoid taxation at the Fund level. Such distributions will be made from the
available cash of the Fund or by liquidation of portfolio securities if
necessary. If a distribution of cash necessitates the liquidation of portfolio
securities, the Investment Manager will select which securities to sell. The
Fund may realize a gain or loss from such sales. In the event the Fund realizes
net capital gains from such transactions, its shareholders may receive a larger
capital gain distribution, if any, than they would in the absence of such
transactions.

     TAXATION OF DIVIDENDS AND DISTRIBUTIONS. Shareholders normally will have
to pay federal income taxes, and any state and/or local income taxes, on the
dividends and other distributions they receive from the Fund. Such dividends
and distributions, to the extent that they are derived from net investment
income or short-term capital gains, are taxable to the shareholder as ordinary
income regardless of whether the shareholder receives such payments in
additional shares or in cash.


     Distributions of net long-term capital gains, if any, are taxable to
shareholders as long-term capital gains regardless of how long a shareholder
has held the Fund's shares and regardless of whether the distribution is
received in additional shares or in cash. The maximum tax on long-term capital
gains applicable to individuals is 20%.


     Shareholders are generally taxed on any ordinary dividend or capital gain
distributions from the Fund in the year they are actually distributed. However,
if any such dividends or distributions are declared in October, November or
December and paid in January then such amounts will be treated for tax purposes
as received by the shareholders on December 31, to shareholders of record of
such month.

     Subject to certain exceptions, a corporate shareholder may be eligible for
a 70% dividends received deduction to the extent that the Fund earns and
distributes qualifying dividends from its investments. Distributions of net
capital gains by the Fund will not be eligible for the dividends received
deduction.

     Shareholders who are not citizens or residents of the United States and
certain foreign entities may be subject to withholding of United States tax on
distributions made by the Fund of investment income and short term capital
gains.

     After the end of each calendar year, shareholders will be sent full
information on their dividends and capital gain distributions for tax purposes,
including the portion taxable as ordinary income, and the portion taxable as
long-term capital gains.

     PURCHASES AND REDEMPTIONS AND EXCHANGES OF FUND SHARES. Any dividend or
capital gains distribution received by a shareholder from any investment
company will have the effect of reducing the net asset value of the
shareholder's stock in that company by the exact amount of the dividend or
capital gains distribution. Furthermore, such dividends and capital gains
distributions are subject to federal income taxes. If the net asset value of
the shares should be reduced below a shareholder's cost as a result of the
payment of dividends or the distribution of realized long-term capital gains,
such payment or distribution would be in part a return of the shareholder's
investment but nonetheless would be taxable to the shareholder. Therefore, an
investor should consider the tax implications of purchasing Fund shares
immediately prior to a distribution record date.

     In general, a sale of shares results in capital gain or loss, and for
individual shareholders, is taxable at a federal rate dependent upon the length
of time the shares were held. A redemption of a shareholder's Fund shares is
normally treated as a sale for tax purposes. Fund shares held for a period of
one year or less will, for tax purposes, generally result in short-term gains
or losses and those held for more than


                                       34
<PAGE>


one year generally result in long-term gain or loss. Under current law, the
maximum tax on long-term capital gains is 20%. Any loss realized by
shareholders upon a sale or redemption of shares within six months of the date
of their purchase will be treated as a long-term capital loss to the extent of
any distributions of net long-term capital gains with respect to such shares
during the six-month period.


     Gain or loss on the sale or redemption of shares in the Fund is measured
by the difference between the amount received and the tax basis of the shares.
Shareholders should keep records of investments made (including shares acquired
through reinvestment of dividends and distributions) so they can compute the
tax basis of their shares. Under certain circumstances a shareholder may
compute and use an average cost basis in determining the gain or loss on the
sale or redemption of shares.

     Exchanges of Fund shares for shares of another fund, including shares of
other Morgan Stanley Dean Witter Funds, are also subject to similar tax
treatment. Such an exchange is treated for tax purposes as a sale of the
original shares in the first fund, followed by the purchase of shares in the
second fund.

     If a shareholder realizes a loss on the redemption or exchange of a fund's
shares and reinvests in that fund's shares within 30 days before or after the
redemption or exchange, the transactions may be subject to the "wash sale"
rules, resulting in a postponement of the recognition of such loss for tax
purposes.


X. UNDERWRITERS
- --------------------------------------------------------------------------------
     The Fund's shares are offered to the public on a continuous basis. The
Distributor, as the principal underwriter of the shares, has certain
obligations under the Distribution Agreement concerning the distribution of the
shares. These obligations and the compensation the Distributor receives are
described above in the sections titled "Principal Underwriter" and "Rule 12b-1
Plans."

XI. CALCULATION OF PERFORMANCE DATA
- --------------------------------------------------------------------------------

     From time to time, the Fund may quote its "total return" in advertisements
and sales literature. These figures are computed separately for Class A, Class
B, Class C and Class D shares. The Fund's "average annual total return"
represents an annualization of the Fund's total return over a particular period
and is computed by finding the annual percentage rate which will result in the
ending redeemable value of a hypothetical $1,000 investment made at the
beginning of a one, five or ten year period, or for the period from the date of
commencement of operations, if shorter than any of the foregoing. The ending
redeemable value is reduced by any contingent deferred sales charge ("CDSC") at
the end of the one, five, ten year or other period. For the purpose of this
calculation, it is assumed that all dividends and distributions are reinvested.
The formula for computing the average annual total return involves a percentage
obtained by dividing the ending redeemable value by the amount of the initial
investment (which in the case of Class A shares is reduced by the Class A
initial sales charge), taking a root of the quotient (where the root is
equivalent to the number of years in the period) and subtracting 1 from the
result. Based on this calculation, the average annual total returns for Class B
for the one year and five year periods ended July 31, 1999 and for the period
October 30, 1992 (commencement of operations) through July 31, 1999 were 4.79%,
17.01% and 11.33%, respectively. The average annual total returns of Class A
for the fiscal year ended July 31, 1999 and for the period July 28, 1997
(inception of the Class) through July 31, 1999 were 4.25% and 7.28%,
respectively. The average annual total returns of Class C for the fiscal year
ended July 31, 1999 and for the period July 28, 1997 through July 31, 1999 were
8.27% and 9.49%, respectively. The average annual total returns of Class D for
the fiscal year ended July 31, 1999 and for the period July 28, 1997 through
July 31, 1999 were 10.22% and 10.44%, respectively.


     In addition, the Fund may advertise its total return for each Class over
different periods of time by means of aggregate, average, year-by-year or other
types of total return figures. These calculations may or may not reflect the
imposition of the maximum front-end sales charge for Class A or the deduction
of the CDSC for each of Class B and Class C which, if reflected, would reduce
the performance quoted. For


                                       35
<PAGE>


example, the average annual total return of the Fund may be calculated in the
manner described above, but without deduction for any applicable sales charge.
Based on this calculation, the average annual total returns of Class B for the
one year and five year periods ended July 31, 1999 and for the period October
30, 1992 (commencement of operations) through July 31, 1999 were 9.12%, 17.22%
and 11.33%, respectively. The average annual total returns of Class A for the
fiscal year ended July 31, 1999 and for the period July 28, 1997 through July
31, 1999 were 10.03% and 10.21%, respectively. The average annual total returns
of Class C for the fiscal year ended July 31, 1999 and for the period July 28,
1997 through July 31, 1999 were 9.13% and 9.49%, respectively. The average
annual total returns of Class D for the fiscal year ended July 31, 1999 and for
the period July 28, 1997 through July 31, 1999 were 10.22% and 10.44%,
respectively.

     In addition, the Fund may compute its aggregate total return for each
Class for specified periods by determining the aggregate percentage rate which
will result in the ending value of a hypothetical $1,000 investment made at the
beginning of the period. For the purpose of this calculation, it is assumed
that all dividends and distributions are reinvested. The formula for computing
aggregate total return involves a percentage obtained by dividing the ending
value (without reduction for any sales charge) by the initial $1,000 investment
and subtracting 1 from the result. Based on this calculation, the total returns
of Class B for the one year and five year periods ended July 31, 1999 and for
the period October 30, 1992 (commencement of operations) through July 31, 1999
were 9.12%, 119.36% and 106.30%, respectively. The total returns of Class A for
the fiscal year ended July 31, 1999 and for the period July 28, 1997 through
July 31, 1999 were 10.03% and 21.53%, respectively. The total returns of Class
C for the fiscal year ended July 31, 1999 and for the period July 28, 1997
through July 31, 1999 were 9.13% and 19.94%, respectively. The total returns of
Class D for the fiscal year ended July 31, 1999 and for the period July 28,
1997 through July 31, 1999 were 10.22% and 22.05%, respectively.


     The Fund may also advertise the growth of hypothetical investments of
$10,000, $50,000 and $100,000 in each Class of shares of the Fund by adding 1
to the Fund's aggregate total return to date (expressed as a decimal and
without taking into account the effect of any applicable CDSC) and multiplying
by $9,475, $48,000 and $97,000 in the case of Class A (investments of $10,000,
$50,000 and $100,000 adjusted for the initial sales charge) or by $10,000,
$50,000 and $100,000 in the case of each of Class B, Class C and Class D, as
the case may be. Investments of $10,000, $50,000 and $100,000 in each Class at
inception of the Class would have grown to the following amounts at July 31,
1999:





<TABLE>
<CAPTION>
                                     INVESTMENT AT INCEPTION OF:
                     INCEPTION   ------------------------------------
CLASS                  DATE:      $10,000      $50,000      $100,000
- -----------------   ----------   ---------   ----------   -----------
<S>                 <C>          <C>         <C>          <C>
Class A .........   07/28/97     $11,515     $58,334      $117,884
Class B .........   10/30/92      20,630     103,150       206,300
Class C .........   07/28/97      11,994      59,970       119,940
Class D .........   07/28/97      12,205      61,025       122,050
</TABLE>


     The Fund from time to time may also advertise its performance relative to
certain performance rankings and indexes compiled by recognized organizations.


XII. FINANCIAL STATEMENTS
- --------------------------------------------------------------------------------

     EXPERTS. The financial statements of the Fund for the fiscal year ended
July 31, 1999 included in this Statement of Additional Information and
incorporated by reference in the Prospectus have been so included and
incorporated in reliance on the report of PricewaterhouseCoopers LLP,
independent accountants, given on the authority of said firm as experts in
auditing and accounting.



                                   * * * * *

     This Statement of Additional Information and the Prospectus do not contain
all of the information set forth in the Registration Statement the Fund has
filed with the SEC. The complete Registration Statement may be obtained from
the SEC.


                                       36
<PAGE>


MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
PORTFOLIO OF INVESTMENTS July 31, 1999






<TABLE>
<CAPTION>
 NUMBER OF
  SHARES                                                         VALUE
- --------------------------------------------------------------------------------
<S>                 <C>                                       <C>
                    COMMON STOCKS (98.1%)
                    Biotechnology (19.9%)
180,000             Amgen Inc.* ...........................   $13,837,500
 35,000             Axogen Ltd.* ..........................     1,111,250
150,000             Biogen, Inc.* .........................    10,312,500
 95,000             Enzon, Inc.* ..........................     2,285,937
 41,300             Genentech, Inc.* ......................     5,864,600
 85,000             Guilford Pharmaceuticals Inc.* ........     1,391,875
 20,000             IDEC Pharmaceuticals Corp.* ...........     1,981,250
 35,000             Immunex Corp.* ........................     3,933,125
175,000             MedImmune, Inc.* ......................    13,945,312
 75,000             QLT Phototherapeutics, Inc.* ..........     4,767,187
                                                              -----------
                                                               59,430,536
                                                              -----------
                    Diversified Commercial Services (2.5%)
200,000             Dendrite International, Inc.* .........     7,587,500
                                                              -----------
                    Drugstore Chains (1.0%)
 60,736             CVS Corp. .............................     3,021,616
                                                              -----------
                    E.D.P. Services (1.0%)
 75,000             National Data Corp. ...................     3,131,250
                                                              -----------
                    Hospital/Nursing Management (0.4%)
 50,000             Columbia/HCA Healthcare Corp. .........     1,112,500
                                                              -----------
                    Major Chemicals (2.0%)
150,000             Monsanto Co. ..........................     5,868,750
                                                              -----------
                    Major Pharmaceuticals (34.6%)
150,000             American Home Products Corp. ..........     7,650,000
195,000             Bristol-Myers Squibb Co. ..............    12,967,500
 75,000             Glaxo Wellcome PLC (ADR)
                    (United Kingdom) ......................     3,914,062
 75,000             Johnson & Johnson .....................     6,909,375
135,000             Lilly (Eli) & Co. .....................     8,859,375
150,000             Merck & Co., Inc. .....................    10,153,125
115,000             Pfizer, Inc. ..........................     3,902,812
175,000             Pharmacia & Upjohn, Inc. ..............     9,417,187
    850             Roche Holding AG (Switzerland) ........     9,400,738
180,000             Schering-Plough Corp. .................     8,820,000
160,000             Smithkline Beecham PLC (ADR)
                    (United Kingdom) ......................     9,610,000
180,203             Warner-Lambert Co. ....................    11,893,398
                                                              -----------
                                                              103,497,572
                                                              -----------
                    Managed Health Care (0.2%)
 45,000             Foundation Health Systems Inc.
                    (Class A) .............................       683,438
                                                              -----------


</TABLE>
<TABLE>
<CAPTION>
    NUMBER OF
      SHARES                                                         VALUE
- --------------------------------------------------------------------------------
<S>                 <C>                                       <C>
                    Medical Equipment & Supplies (3.2%)
132,917             Medtronic, Inc. .......................   $ 9,578,331
                                                              -----------
                    Medical Specialties (6.0%)
 40,000             Bard (C.R.), Inc. .....................     1,945,000
191,400             Boston Scientific Corp.* ..............     7,763,663
 65,000             Invitrogen Corp.* .....................     1,880,938
 30,000             Perclose, Inc.* .......................     1,522,500
 80,000             Stryker Corp. .........................     4,880,000
                                                              -----------
                                                               17,992,101
                                                              -----------
                    Medical/Dental Distributors (6.3%)
257,875             Cardinal Health, Inc. .................    17,599,969
100,000             Women First HealthCare, Inc.* .........     1,125,000
                                                              -----------
                                                               18,724,969
                                                              -----------
                    Medical/Nursing Services (0.1%)
 40,000             Sight Resource Corp. (Units)++* .......       162,500
                                                              -----------
                    Multi-Line Insurance (2.2%)
 75,000             CIGNA Corp. ...........................     6,614,063
                                                              -----------
                    Other Consumer Services (0.3%)
 45,000             drkoop.com, Inc.* .....................       990,000
                                                              -----------
                    Other Pharmaceuticals (10.7%)
 70,000             Aviron* ...............................     1,977,500
290,000             Elan Corp. PLC (ADR) (Ireland)*........     8,428,125
185,000             Forest Laboratories, Inc.* ............     9,481,250
 50,000             Roberts Pharmaceutical Corp.* .........     1,371,875
180,000             Sanofi-Synthelabo S.A. (France)* ......     7,486,007
125,000             Shire Pharmaceuticals Group PLC
                    (ADR) (United Kingdom)* ...............     3,171,875
                                                              -----------
                                                               31,916,632
                                                              -----------
                    Services to the Health Industry (7.7%)
 50,000             CareInsite, Inc.* .....................     2,150,000
260,000             IMS Health Inc. .......................     7,247,500
 50,800             Mede America Corp.* ...................     1,422,400
 21,875             Medical Manager Corp.* ................     1,387,695
165,000             MedQuist Inc.* ........................     7,105,313
 46,700             ProVantage Health Services, Inc. ......       863,950
 50,000             Shared Medical Systems Corp. ..........     2,993,750
                                                              -----------
                                                               23,170,608
                                                              -----------
                    TOTAL COMMON STOCKS
                    (Identified Cost $236,415,810).........   293,482,366
                                                              -----------
</TABLE>



                       SEE NOTES TO FINANCIAL STATEMENTS
                                       37
<PAGE>

MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
PORTFOLIO OF INVESTMENTS July 31, 1999, continued



<TABLE>
<CAPTION>
 PRINCIPAL
 AMOUNT IN
 THOUSANDS                                                  VALUE
- --------------------------------------------------------------------------------
<S>           <C>                                      <C>
              SHORT-TERM INVESTMENT (0.4%)
              REPURCHASE AGREEMENT
$  1,282      The Bank of New York 5.00%
              due 08/02/99 (dated 07/30/99;
              proceeds $1,282,464) (a)
              (Identified Cost $1,281,930)..........   $  1,281,930
                                                       ------------
TOTAL INVESTMENTS
(Identified Cost $237,697,740) (b).........    98.5%    294,764,296
   CASH AND OTHER ASSETS IN
   EXCESS OF LIABILITIES ..................     1.5       4,436,367
                                              -----    ------------
   NET ASSETS .............................   100.0%   $299,200,663
                                              =====    ============
</TABLE>

- --------------------------------
ADR      American Depository Receipt.
*        Non-income producing security.
++       Consists of more than one class of securities traded together as a
         unit; common stocks with attached warrants.
(a)      Collateralized by $1,109,968 U.S. Treasury Bond 10.75% due 05/15/03
         valued at $1,310,645.
(b)      The aggregate cost for federal income tax purposes approximates
         identified cost. The aggregate gross unrealized appreciation is
         $61,314,283 and the aggregate gross unrealized depreciation is
         $4,247,727, resulting in net unrealized appreciation of $57,066,556.



                       SEE NOTES TO FINANCIAL STATEMENTS
                                       38
<PAGE>


MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
FINANCIAL STATEMENTS





STATEMENT OF ASSETS AND LIABILITIES
July 31, 1999




<TABLE>
<S>                                                  <C>
ASSETS:
Investments in securities, at value
   (identified cost $237,697,740).................    $294,764,296
Cash .............................................       1,951,055
Receivable for:
     Investments sold ............................       9,895,868
     Dividends ...................................         151,419
     Shares of beneficial interest sold ..........         115,033
     Foreign withholding taxes reclaimed .........          50,487
Prepaid expenses and other assets ................          21,925
                                                      ------------
     TOTAL ASSETS ................................     306,950,083
                                                      ------------
LIABILITIES:
Payable for:
     Investments purchased .......................       6,711,157
     Shares of beneficial interest
        repurchased ..............................         431,323
     Investment management fee ...................         265,425
     Plan of distribution fee ....................         262,583
Accrued expenses and other payables ..............          78,932
                                                      ------------
     TOTAL LIABILITIES ...........................       7,749,420
                                                      ------------
     NET ASSETS ..................................    $299,200,663
                                                      ============
COMPOSITION OF NET ASSETS:
Paid-in-capital ..................................    $224,799,391
Net unrealized appreciation ......................      57,067,808
Accumulated net investment loss ..................         (39,563)
Accumulated undistributed net realized gain             17,373,027
                                                      ------------
     NET ASSETS ..................................    $299,200,663
                                                      ============
CLASS A SHARES:
Net Assets .......................................    $    707,217
Shares Outstanding (unlimited authorized,
   $.01 par value) ...............................          52,800
     NET ASSET VALUE PER SHARE ...................    $      13.39
                                                      ============
     MAXIMUM OFFERING PRICE PER SHARE,
        (net asset value plus 5.54% of net
        asset value) .............................    $      14.13
                                                      ============
CLASS B SHARES:
Net Assets .......................................    $295,446,122
Shares Outstanding (unlimited authorized,
   $.01 par value) ...............................      22,432,249
     NET ASSET VALUE PER SHARE ...................    $      13.17
                                                      ============
CLASS C SHARES:
Net Assets .......................................    $  1,562,044
Shares Outstanding (unlimited authorized,
   $.01 par value) ...............................         118,546
     NET ASSET VALUE PER SHARE ...................    $      13.18
                                                      ============
CLASS D SHARES:
Net Assets .......................................    $  1,485,280
Shares Outstanding (unlimited authorized,
   $.01 par value) ...............................         110,380
     NET ASSET VALUE PER SHARE ...................    $      13.46
                                                      ============
</TABLE>



STATEMENT OF OPERATIONS
For the year ended July 31, 1999



<TABLE>
<S>                                                   <C>
NET INVESTMENT LOSS:
INCOME
Dividends (net of $56,068 foreign
   withholding tax) ...............................   $ 1,857,458
Interest ..........................................       579,517
                                                      -----------
     TOTAL INCOME .................................     2,436,975
                                                      -----------
EXPENSES
Investment management fee .........................     3,320,393
Plan of distribution fee (Class A shares) .........         1,354
Plan of distribution fee (Class B shares) .........     3,292,077
Plan of distribution fee (Class C shares) .........        10,873
Transfer agent fees and expenses ..................       575,858
Shareholder reports and notices ...................        91,283
Registration fees .................................        84,805
Professional fees .................................        63,906
Custodian fees ....................................        49,554
Trustees' fees and expenses .......................        19,020
Other .............................................         8,675
                                                      -----------
     TOTAL EXPENSES ...............................     7,517,798
                                                      -----------
     NET INVESTMENT LOSS ..........................    (5,080,823)
                                                      -----------
NET REALIZED AND UNREALIZED GAIN:
Net realized gain/loss on:
     Investments ..................................    33,703,467
     Foreign exchange transactions ................          (188)
                                                      -----------
     NET GAIN .....................................    33,703,279
                                                      -----------
Net change in unrealized
   appreciation/depreciation on:
     Investments ..................................     1,018,963
     Translation of forward foreign currency
        contracts, other assets and liabilities
        denominated in foreign currencies .........         6,890
                                                      -----------
     NET APPRECIATION .............................     1,025,853
                                                      -----------
     NET GAIN .....................................    34,729,132
                                                      -----------
NET INCREASE ......................................   $29,648,309
                                                      ===========
</TABLE>




                       SEE NOTES TO FINANCIAL STATEMENTS
                                       39
<PAGE>

MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
FINANCIAL STATEMENTS, continued


STATEMENT OF CHANGES IN NET ASSETS




<TABLE>
<CAPTION>
                                                         FOR THE YEAR    FOR THE YEAR
                                                            ENDED            ENDED
                                                        JULY 31, 1999    JULY 31, 1998
                                                       --------------- ----------------
<S>                                                    <C>             <C>
INCREASE (DECREASE) IN NET ASSETS:
OPERATIONS:
Net investment loss ..................................  $  (5,080,823)  $  (7,505,328)
Net realized gain ....................................     33,703,279     100,959,963
Net change in unrealized appreciation ................      1,025,853     (55,763,026)
                                                        -------------   -------------
   NET INCREASE ......................................     29,648,309      37,691,609
                                                        -------------   -------------
DISTRIBUTIONS TO SHAREHOLDERS FROM NET REALIZED
GAIN:
Class A shares .......................................       (130,161)         (7,675)
Class B shares .......................................    (77,763,028)    (29,731,527)
Class C shares .......................................       (209,238)        (13,129)
Class D shares .......................................       (255,944)         (1,158)
                                                        -------------   -------------
   TOTAL DISTRIBUTIONS ...............................    (78,358,371)    (29,753,489)
                                                        -------------   -------------
Net decrease from transactions in shares of beneficial
  interest ...........................................     (9,495,367)    (73,239,092)
                                                        -------------   -------------
   NET DECREASE ......................................    (58,205,429)    (65,300,972)
NET ASSETS:
Beginning of period ..................................    357,406,092     422,707,064
                                                        -------------   -------------
   END OF PERIOD
   (Including accumulated net investment losses of
   $39,563 and $36,149, respectively).................  $ 299,200,663   $ 357,406,092
                                                        =============   =============
</TABLE>


                       SEE NOTES TO FINANCIAL STATEMENTS
                                       40
<PAGE>


MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
NOTES TO FINANCIAL STATEMENTS July 31, 1999





1. ORGANIZATION AND ACCOUNTING POLICIES

Morgan Stanley Dean Witter Health Sciences Trust (the "Fund") is registered
under the Investment Company Act of 1940, as amended (the "Act"), as a
non-diversified, open-end management investment company. The Fund's investment
objective is capital appreciation. The Fund seeks to achieve its objective by
investing in securities of companies in the health sciences industry throughout
the world. The Fund was organized as a Massachusetts business trust on May 26,
1992 and commenced operations on October 30, 1992. On July 28, 1997, the Fund
converted to a multiple class share structure.

The Fund offers Class A shares, Class B shares, Class C shares and Class D
shares. The four classes are substantially the same except that most Class A
shares are subject to a sales charge imposed at the time of purchase, some
Class A shares, and most Class B shares and Class C shares are subject to a
contingent deferred sales charge imposed on shares redeemed within one year,
six years and one year, respectively. Class D shares are not subject to a sales
charge. Additionally, Class A shares, Class B shares and Class C shares incur
distribution expenses.

The preparation of financial statements in accordance with generally accepted
accounting principles requires management to make estimates and assumptions
that affect the reported amounts and disclosures. Actual results could differ
from those estimates.

The following is a summary of significant accounting policies:


A. VALUATION OF INVESTMENTS -- (1) an equity security listed or traded on the
New York or American or other domestic or foreign stock exchange is valued at
its latest sale price on that exchange prior to the time when assets are
valued; if there were no sales that day, the security is valued at the latest
bid price (in cases where a security is traded on more than one exchange, the
security is valued on the exchange designated as the primary market pursuant to
procedures adopted by the Trustees); (2) all other portfolio securities for
which over-the-counter market quotations are readily available are valued at
the latest available bid price prior to the time of valuation; (3) when market
quotations are not readily available, including circumstances under which it is
determined by Morgan Stanley Dean Witter Advisors Inc. (the "Investment
Manager") that sale or bid prices are not reflective of a security's market
value, portfolio securities are valued at their fair value as determined in
good faith under procedures established by and under the general supervision of
the Trustees (valuation of debt securities for which market quotations are not
readily available may be based upon current market prices of securities which
are comparable in coupon, rating and maturity or an appropriate matrix
utilizing similar factors); and (4) short-term debt securities having a
maturity date of more than sixty days at time of purchase are valued on a



                                       41
<PAGE>

MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
NOTES TO FINANCIAL STATEMENTS July 31, 1999, continued


mark-to-market basis until sixty days prior to maturity and thereafter at
amortized cost based on their value on the 61st day. Short-term debt securities
having a maturity date of sixty days or less at the time of purchase are valued
at amortized cost.


B. ACCOUNTING FOR INVESTMENTS -- Security transactions are accounted for on the
trade date (date the order to buy or sell is executed). Realized gains and
losses on security transactions are determined by the identified cost method.
Dividend income and other distributions are recorded on the ex-dividend date
except for certain dividends from foreign securities which are recorded as soon
as the Fund is informed after the ex-dividend date. Discounts are accreted over
the life of the respective securities. Interest income is accrued daily.


C. MULTIPLE CLASS ALLOCATIONS -- Investment income, expenses (other than
distribution fees), and realized and unrealized gains and losses are allocated
to each class of shares based upon the relative net asset value on the date
such items are recognized. Distribution fees are charged directly to the
respective class.


D. FOREIGN CURRENCY TRANSLATION -- The books and records of the Fund are
maintained in U.S. dollars as follows: (1) the foreign currency market value of
investment securities, other assets and liabilities and forward foreign
currency contracts are translated at the exchange rates prevailing at the end
of the period; and (2) purchases, sales, income and expenses are translated at
the exchange rates prevailing on the respective dates of such transactions. The
resultant exchange gains and losses are included in the Statement of
Operations. Pursuant to U.S. Federal income tax regulations, certain foreign
exchange gains/losses included in realized and unrealized gain/loss are
included in or are a reduction of ordinary income for federal income tax
purposes. The Fund does not isolate that portion of the results of operations
arising as a result of changes in the foreign exchange rates from the changes
in the market prices of the securities.


E. FORWARD FOREIGN CURRENCY CONTRACTS -- The Fund may enter into forward
foreign currency contracts which are valued daily at the appropriate exchange
rates. The resultant unrealized exchange gains and losses are included in the
Statement of Operations as unrealized gain/loss on foreign exchange
transactions. The Fund records realized gains or losses on delivery of the
currency or at the time the forward contract is extinguished (compensated) by
entering into a closing transaction prior to delivery.


F. FEDERAL INCOME TAX STATUS -- It is the Fund's policy to comply with the
requirements of the Internal Revenue Code applicable to regulated investment
companies and to distribute all of its taxable income to its shareholders.
Accordingly, no federal income tax provision is required.



                                       42
<PAGE>

MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
NOTES TO FINANCIAL STATEMENTS July 31, 1999, continued


G. DIVIDENDS AND DISTRIBUTIONS TO SHAREHOLDERS -- The Fund records dividends
and distributions to its shareholders on the ex-dividend date. The amount of
dividends and distributions from net investment income and net realized capital
gains are determined in accordance with federal income tax regulations which
may differ from generally accepted accounting principles. These "book/tax"
differences are either considered temporary or permanent in nature. To the
extent these differences are permanent in nature, such amounts are reclassified
within the capital accounts based on their federal tax-basis treatment;
temporary differences do not require reclassification. Dividends and
distributions which exceed net investment income and net realized capital gains
for financial reporting purposes but not for tax purposes are reported as
dividends in excess of net investment income or distributions in excess of net
realized capital gains. To the extent they exceed net investment income and net
realized capital gains for tax purposes, they are reported as distributions of
paid-in-capital.


2. INVESTMENT MANAGEMENT AGREEMENT

Pursuant to an Investment Management Agreement, the Fund pays the Investment
Manager a management fee, accrued daily and payable monthly, by applying the
following annual rates to the net assets of the Fund determined at the close of
each business day: 1.0% to the portion of daily net assets not exceeding $500
million and 0.95% to the portion of daily net assets exceeding $500 million.

Under the terms of the Agreement, in addition to managing the Fund's
investments, the Investment Manager maintains certain of the Fund's books and
records and furnishes, at its own expense, office space, facilities, equipment,
clerical, bookkeeping and certain legal services and pays the salaries of all
personnel, including officers of the Fund who are employees of the Investment
Manager. The Investment Manager also bears the cost of telephone services,
heat, light, power and other utilities provided to the Fund.


3. PLAN OF DISTRIBUTION

Shares of the Fund are distributed by Morgan Stanley Dean Witter Distributors
Inc. (the "Distributor"), an affiliate of the Investment Manager. The Fund has
adopted a Plan of Distribution (the "Plan") pursuant to Rule 12b-1 under the
Act. The Plan provides that the Fund will pay the Distributor a fee which is
accrued daily and paid monthly at the following annual rates: (i) Class A -- up
to 0.25% of the average daily net assets of Class A; (ii) Class B -- 1.0% of
the lesser of: (a) the average daily aggregate gross sales of the Class B
shares since the inception of the Fund (not including reinvestment of dividend
or capital gain distributions) less the average daily aggregate net asset value
of the Class B shares redeemed since the Fund's inception upon which a
contingent deferred sales charge has been imposed or waived; or (b) the average
daily net assets of Class B; and (iii) Class C -- up to 1.0% of the average
daily net assets of Class C. In the case of Class A shares, amounts paid under
the Plan are paid to the Distributor for



                                       43
<PAGE>

MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
NOTES TO FINANCIAL STATEMENTS July 31, 1999, continued


services provided. In the case of Class B and Class C shares, amounts paid
under the Plan are paid to the Distributor for (1) services provided and the
expenses borne by it and others in the distribution of the shares of these
Classes, including the payment of commissions for sales of these Classes and
incentive compensation to, and expenses of, Morgan Stanley Dean Witter
Financial Advisors and others who engage in or support distribution of the
shares or who service shareholder accounts, including overhead and telephone
expenses; (2) printing and distribution of prospectuses and reports used in
connection with the offering of these shares to other than current
shareholders; and (3) preparation, printing and distribution of sales
literature and advertising materials. In addition, the Distributor may utilize
fees paid pursuant to the Plan, in the case of Class B shares, to compensate
Dean Witter Reynolds Inc. ("DWR"), an affiliate of the Investment Manager and
Distributor, and other selected broker-dealers for their opportunity costs in
advancing such amounts, which compensation would be in the form of a carrying
charge on any unreimbursed expenses.

In the case of Class B shares, provided that the Plan continues in effect, any
cumulative expenses incurred by the Distributor but not yet recovered may be
recovered through the payment of future distribution fees from the Fund
pursuant to the Plan and contingent deferred sales charges paid by investors
upon redemption of Class B shares. Although there is no legal obligation for
the Fund to pay expenses incurred in excess of payments made to the Distributor
under the Plan and the proceeds of contingent deferred sales charges paid by
investors upon redemption of shares, if for any reason the Plan is terminated,
the Trustees will consider at that time the manner in which to treat such
expenses. The Distributor has advised the Fund that such excess amounts,
including carrying charges, totaled $12,500,579 at July 31, 1999.

In the case of Class A shares and Class C shares, expenses incurred pursuant to
the Plan in any calendar year in excess of 0.25% or 1.0% of the average daily
net assets of Class A or Class C, respectively, will not be reimbursed by the
Fund through payments in any subsequent year, except that expenses representing
a gross sales credit to Morgan Stanley Dean Witter Financial Advisors or other
selected broker-dealer representatives may be reimbursed in the subsequent
calendar year. For the year ended July 31, 1999, the distribution fee was
accrued for Class A shares and Class C shares at the annual rate of 0.20% and
1.0%, respectively.

The Distributor has informed the Fund that for the year ended July 31, 1999, it
received contingent deferred sales charges from certain redemptions of the
Fund's Class A shares, Class B shares and Class C shares of $262, $510,447, and
$2,103, respectively and received $9,271, in front-end sales charges from sales
of the Fund's Class A shares. The respective shareholders pay such charges
which are not an expense of the Fund.



                                       44
<PAGE>

MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
NOTES TO FINANCIAL STATEMENTS July 31, 1999, continued


4. SECURITY TRANSACTIONS AND TRANSACTIONS WITH AFFILIATES

The cost of purchases and proceeds from sales of portfolio securities,
excluding short-term investments, for the year ended July 31, 1999, aggregated
$472,189,629 and $547,467,862, respectively.

For the year ended July 31, 1999, the Fund incurred brokerage commissions of
$213,176 with DWR for portfolio transactions executed on behalf of the Fund. At
July 31, 1999, the Fund's receivable for investments sold included unsettled
trades with DWR of $3,731,144.

For the year ended July 31, 1999, the Fund incurred brokerage commissions of
$37,760 with Morgan Stanley & Co., Inc., an affiliate of the Investment Manager
and Distributor, for portfolio transactions executed on behalf of the Fund. At
July 31, 1999, the Fund's receivable for investments sold included unsettled
trades with Morgan Stanley & Co., Inc. of $515,733.

Morgan Stanley Dean Witter Trust FSB, an affiliate of the Investment Manager
and Distributor, is the Fund's transfer agent. At July 31, 1999, the Fund had
transfer agent fees and expenses payable of approximately $900.

The Fund has an unfunded noncontributory defined benefit pension plan covering
all independent Trustees of the Fund who will have served as independent
Trustees for at least five years at the time of retirement. Benefits under this
plan are based on years of service and compensation during the last five years
of service. Aggregate pension costs for the year ended July 31, 1999 included
in Trustees' fees and expenses in the Statement of Operations amounted to
$5,490. At July 31, 1999, the Fund had an accrued pension liability of $39,375
which is included in accrued expenses in the Statement of Assets and
Liabilities.


5. PURPOSES OF AND RISKS RELATING TO CERTAIN FINANCIAL INSTRUMENTS

The Fund may enter into forward foreign currency contracts ("forward
contracts") to facilitate settlement of foreign currency denominated portfolio
transactions or to manage foreign currency exposure associated with foreign
currency denominated securities.

Forward contracts involve elements of market risk in excess of the amounts
reflected in the Statement of Assets and Liabilities. The Fund bears the risk
of an unfavorable change in the foreign exchange rates underlying the forward
contracts. Risks may also arise upon entering into these contracts from the
potential inability of the counterparties to meet the terms of their contracts.


At July 31, 1999, there were no outstanding forward contracts.


                                       45
<PAGE>

MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
NOTES TO FINANCIAL STATEMENTS July 31, 1999, continued


6. SHARES OF BENEFICIAL INTEREST

Transactions in shares of beneficial interest were as follows:





<TABLE>
<CAPTION>
                                                   FOR THE YEAR                       FOR THE YEAR
                                                      ENDED                              ENDED
                                                  JULY 31, 1999                      JULY 31, 1998
                                        ---------------------------------- ----------------------------------
                                             SHARES            AMOUNT            SHARES           AMOUNT
                                        ---------------- ----------------- ---------------- -----------------
<S>                                     <C>              <C>               <C>              <C>
CLASS A SHARES
Sold ..................................        424,913    $    6,073,934          152,175    $    2,404,229
Reinvestment of distributions .........          9,853           130,161              558             7,674
Redeemed ..............................       (398,961)       (5,796,005)        (136,405)       (2,170,034)
                                           -----------    --------------      -----------    --------------
Net increase -- Class A ...............         35,805           408,090           16,328           241,869
                                           -----------    --------------      -----------    --------------
CLASS B SHARES
Sold ..................................      7,959,920       112,709,190        6,622,726       102,936,128
Reinvestment of distributions .........      5,515,305        72,029,887        2,032,581        27,866,668
Redeemed ..............................    (14,392,068)     (196,123,403)     (13,300,594)     (205,944,607)
                                           -----------    --------------      -----------    --------------
Net decrease -- Class B ...............       (916,843)      (11,384,326)      (4,645,287)      (75,141,811)
                                           -----------    --------------      -----------    --------------
CLASS C SHARES
Sold ..................................        137,139         1,870,790           36,728           575,630
Reinvestment of distributions .........         15,661           204,533              941            12,903
Redeemed ..............................        (66,135)         (874,166)          (7,117)         (111,331)
                                           -----------    --------------      -----------    --------------
Net increase -- Class C ...............         86,665         1,201,157           30,552           477,202
                                           -----------    --------------      -----------    --------------
CLASS D SHARES
Sold ..................................        469,661         6,297,099          211,349         3,206,216
Reinvestment of distributions .........            279             3,702               83             1,142
Redeemed ..............................       (440,582)       (6,021,089)        (131,077)       (2,023,710)
                                           -----------    --------------      -----------    --------------
Net increase -- Class D ...............         29,358           279,712           80,355         1,183,648
                                           -----------    --------------      -----------    --------------
Net decrease in Fund ..................       (765,015)   $   (9,495,367)      (4,518,052)   $  (73,239,092)
                                           ===========    ==============      ===========    ==============
</TABLE>



7. FEDERAL INCOME TAX STATUS

At July 31, 1999, the Fund had temporary book/tax differences primarily
attributable to capital loss deferrals on wash sales and permanent book/tax
differences primarily attributable to a net operating loss. To reflect
reclassifications arising from the permanent differences, accumulated
undistributed net realized gain was charged and accumulated net investment loss
was credited $5,077,409.



                                       46
<PAGE>


MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
FINANCIAL HIGHLIGHTS

Selected ratios and per share data for a share of beneficial interest
outstanding throughout each period:






<TABLE>
<CAPTION>
                                                                                            FOR THE PERIOD
                                                     FOR THE YEAR        FOR THE YEAR      JULY 28, 1997*
                                                         ENDED              ENDED              THROUGH
                                                     JULY 31, 1999      JULY 31, 1998       JULY 31, 1997
                                                  ------------------   ---------------   ------------------
<S>                                               <C>                  <C>               <C>
CLASS A SHARES++
SELECTED PER SHARE DATA:
Net asset value, beginning of period ..........        $ 15.31          $ 15.10               $ 15.03
                                                       -------          -------               -------
Income (loss) from investment operations:
 Net investment loss ..........................        ( 0.10)          ( 0.18)                  --
 Net realized and unrealized gain .............          1.59             1.55                  0.07
                                                       -------          -------               -------
Total income from investment operations .......          1.49             1.37                  0.07
                                                       -------          -------               -------
Less distributions from net realized gain .....        ( 3.41)          ( 1.16)                  --
                                                       -------          -------               -------
Net asset value, end of period ................        $ 13.39          $ 15.31               $ 15.10
                                                       =======          =======               =======
TOTAL RETURN+ .................................          10.03 %           9.94 %                0.47 %(1)
RATIOS TO AVERAGE NET ASSETS:
Expenses ......................................           1.47 %(3)        1.51 %                1.57 %(2)
Net investment loss ...........................          (0.74)%(3)       (1.06)%               (0.55)%(2)
SUPPLEMENTAL DATA:
Net assets, end of period, in thousands .......         $ 707             $ 260                $   10
Portfolio turnover rate .......................           148 %             139 %                  85 %
</TABLE>



- -------------
*     The date shares were first issued.

++    The per share amounts were computed using an average number of shares
      outstanding during the period.

+     Does not reflect the deduction of sales charge. Calculated based on the
      net asset value as of the last business day of the period.

(1)   Not annualized.

(2)   Annualized.

(3)   Reflects overall Fund ratios for investment income and non-class specific
      expenses.


                       SEE NOTES TO FINANCIAL STATEMENTS
                                       47
<PAGE>

MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
FINANCIAL HIGHLIGHTS, continued



<TABLE>
<CAPTION>
                                                                           FOR THE YEAR ENDED JULY 31,
                                                ----------------------------------------------------------------------------------
                                                      1999++            1998++          1997*            1996            1995
                                                ------------------ --------------- --------------- --------------- ---------------
<S>                                             <C>                <C>             <C>             <C>             <C>
CLASS B SHARES
SELECTED PER SHARE DATA:
Net asset value, beginning of period ..........        $    15.22       $    15.10      $    14.97      $    12.88      $     9.32
                                                       ----------       ----------      ----------      ----------      ----------
Income (loss) from investment operations:
 Net investment loss ..........................            ( 0.21)          ( 0.31)         ( 0.31)         ( 0.26)         ( 0.24)
 Net realized and unrealized gain .............              1.57             1.59            1.39            3.44            3.80
                                                       ----------       ----------      ----------      ----------      ----------
Total income from investment operations .......              1.36             1.28            1.08            3.18            3.56
                                                       ----------       ----------      ----------      ----------      ----------
Less distributions from net realized gain .....            ( 3.41)          ( 1.16)         ( 0.95)         ( 1.09)             --
                                                       ----------       ----------      ----------      ----------      ----------
Net asset value, end of period ................        $    13.17       $    15.22      $    15.10      $    14.97      $    12.88
                                                       ==========       ==========      ==========      ==========      ==========
TOTAL RETURN+ .................................              9.12 %           9.33 %          7.55 %         24.84 %         38.20 %
RATIOS TO AVERAGE NET ASSETS:
Expenses ......................................              2.27 %(1)        2.26 %          2.25 %          2.20 %          2.30 %
Net investment loss ...........................             (1.54)%(1)       (1.87)%         (2.08)%         (2.03)%         (2.05)%
SUPPLEMENTAL DATA:
Net assets, end of period, in thousands .......          $295,446         $355,416        $422,667        $442,876        $273,735
Portfolio turnover rate .......................               148 %            139 %            85 %            63 %           145 %
</TABLE>



- -------------
*     Prior to July 28, 1997, the Fund issued one class of shares. All shares
      of the Fund held prior to that date have been designated Class B shares.

++    The per share amounts were computed using an average number of shares
outstanding during the period.

+     Does not reflect the deduction of sales charge. Calculated based on the
net asset value as of the last business day of the period.

(1)   Reflects overall Fund ratios for investment income and non-class specific
      expenses.


                       SEE NOTES TO FINANCIAL STATEMENTS
                                       48
<PAGE>

MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
FINANCIAL HIGHLIGHTS, continued



<TABLE>
<CAPTION>
                                                                                               FOR THE PERIOD
                                                         FOR THE YEAR        FOR THE YEAR      JULY 28, 1997*
                                                             ENDED              ENDED              THROUGH
                                                         JULY 31, 1999      JULY 31, 1998       JULY 31, 1997
                                                      ------------------   ---------------   ------------------
<S>                                                   <C>                  <C>               <C>
CLASS C SHARES++
SELECTED PER SHARE DATA:
Net asset value, beginning of period ..............         $ 15.23         $ 15.10               $ 15.03
                                                            -------         -------               -------
Income (loss) from investment operations:
 Net investment loss ..............................           (0.21)          (0.29)                  --
 Net realized and unrealized gain .................            1.57            1.58                  0.07
                                                            -------         -------               -------
Total income from investment operations ...........            1.36            1.29                  0.07
                                                            -------         -------               -------
Less distributions from net realized gain .........           (3.41)          (1.16)                  --
                                                            -------         -------               -------
Net asset value, end of period ....................          $13.18         $ 15.23               $ 15.10
                                                            =======         =======               =======
TOTAL RETURN+ .....................................            9.13 %          9.40  %               0.47 %(1)
RATIOS TO AVERAGE NET ASSETS:
Expenses ..........................................            2.27 %(3)       2.27 %                2.31 %(2)
Net investment loss ...............................           (1.54)%(3)      (1.78)%              ( 1.28)%(2)
SUPPLEMENTAL DATA:
Net assets, end of period, in thousands ...........          $1,562           $ 485               $    20
Portfolio turnover rate ...........................             148 %           139 %                  85 %
</TABLE>



- -------------
*     The date shares were first issued.
++    The per share amounts were computed using an average number of shares
      outstanding during the period.
+     Does not reflect the deduction of sales charge. Calculated based on the
      net asset value as of the last business day of the period.
(1)   Not annualized.
(2)   Annualized.
(3)   Reflects overall Fund ratios for investment income and non-class specific
      expenses.


                       SEE NOTES TO FINANCIAL STATEMENTS
                                       49
<PAGE>

MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
FINANCIAL HIGHLIGHTS, continued



<TABLE>
<CAPTION>
                                                                                               FOR THE PERIOD
                                                         FOR THE YEAR        FOR THE YEAR      JULY 28, 1997*
                                                             ENDED              ENDED              THROUGH
                                                         JULY 31, 1999      JULY 31, 1998       JULY 31, 1997
                                                      ------------------   ---------------   ------------------
<S>                                                   <C>                  <C>               <C>
CLASS D SHARES++
SELECTED PER SHARE DATA:
Net asset value, beginning of period ..............         $15.35           $15.10               $15.03
                                                            -------          -------              -------
Income (loss) from investment operations:
 Net investment loss ..............................          (0.09)           (0.14)                 --
 Net realized and unrealized gain .................           1.61             1.55                 0.07
                                                            -------          -------              -------
Total income from investment operations ...........           1.52             1.41                 0.07
                                                            -------          -------              -------
Less distributions from net realized gain .........          (3.41)           (1.16)                 --
                                                            -------          -------              -------
Net asset value, end of period ....................         $13.46           $15.35               $15.10
                                                            =======          =======              =======
TOTAL RETURN+ .....................................          10.22 %          10.22 %               0.47 %(1)
RATIOS TO AVERAGE NET ASSETS:
Expenses ..........................................           1.27 %(3)        1.26 %               1.31 %(2)
Net investment loss ...............................          (0.54)%(3)       (0.79)%              (0.29)%(2)
SUPPLEMENTAL DATA:
Net assets, end of period, in thousands ...........         $1,485           $1,244               $   10
Portfolio turnover rate ...........................            148 %            139 %                 85 %
</TABLE>



- -------------
*     The date shares were first issued.
++    The per share amounts were computed using an average number of shares
      outstanding during the period.
+     Calculated based on the net asset value as of the last business day of
      the period.
(1)   Not annualized.
(2)   Annualized.
(3)   Reflects overall Fund ratios for investment income and non-class specific
      expenses.


                       SEE NOTES TO FINANCIAL STATEMENTS
                                       50
<PAGE>


MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
REPORT OF INDEPENDENT ACCOUNTANTS


TO THE SHAREHOLDERS AND TRUSTEES
OF MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST



In our opinion, the accompanying statement of assets and liabilities, including
the portfolio of investments, and the related statements of operations and of
changes in net assets and the financial highlights present fairly, in all
material respects, the financial position of Morgan Stanley Dean Witter Health
Sciences Trust (the "Fund") at July 31, 1999, the results of its operations for
the year then ended, the changes in its net assets for each of the two years in
the period then ended and the financial highlights for each of the periods
presented, in conformity with generally accepted accounting principles. These
financial statements and financial highlights (hereafter referred to as
"financial statements") are the responsibility of the Fund's management; our
responsibility is to express an opinion on these financial statements based on
our audits. We conducted our audits of these financial statements in accordance
with generally accepted auditing standards which require that we plan and
perform the audit to obtain reasonable assurance about whether the financial
statements are free of material misstatement. An audit includes examining, on a
test basis, evidence supporting the amounts and disclosures in the financial
statements, assessing the accounting principles used and significant estimates
made by management, and evaluating the overall financial statement presentation.
We believe that our audits, which included confirmation of securities at July
31, 1999 by correspondence with the custodian and brokers, provide a reasonable
basis for the opinion expressed above.


PricewaterhouseCoopers LLP
1177 Avenue of the Americas
New York, New York 10036
September 9, 1999

                      1999 FEDERAL TAX NOTICE (unaudited)

During the year ended July 31, 1999, the Fund paid to its shareholders $3.41 per
share from long-term capital gains.




                                       51


<PAGE>

                MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
                            PART C OTHER INFORMATION


Item 23. Exhibits
- -------- --------

1(a).    Declaration of Trust of the Registrant, dated May 26, 1992, is
         incorporated by reference to Exhibit 1 of Post-Effective Amendment No.
         4 to the Registration Statement on Form N-1A, filed on September 27,
         1995.

1(b).    Amendment, dated June 22, 1998, to the Declaration of Trust of the
         Registrant is incorporated by reference to Exhibit 1 of Post Effective
         Amendment No. 8 to the Registration Statement on Form N-1A, filed on
         September 25, 1998.

1(c).    Instrument Establishing and Designating Additional Classes is
         incorporated by reference to Exhibit 1 of Post-Effective Amendment No.
         6 to the Registration Statement on Form N-1A, filed on July 17, 1997.

2.       Amended and Restated By-Laws of the Registrant dated May 1, 1999 is
         incorporated by reference to Exhibit 2 of Post-Effective Amendment No.
         9 to the Registration Statement on Form N-1A, filed on July 29, 1999.

3. Not applicable.

4.       Amended Investment Management Agreement between the Registrant and
         Morgan Stanley Dean Witter Advisors Inc. is incorporated by reference
         to Exhibit 5 of Post-Effective Amendment No. 8 to the Registration
         Statement on Form N-1A, filed on September 25, 1998.

5(a).    Amended Distribution Agreement between the Registrant and Morgan
         Stanley Dean Witter Advisors Inc. is incorporated by reference to
         Exhibit 6 of Post-Effective Amendment No. 8 to the Registration
         Statement on Form N-1A, filed on September 25, 1998.

5(b).    Selected Dealer Agreement between the Registrant and Morgan Stanley
         Dean Witter Distributors Inc. is incorporated by reference to Exhibit
         6(b) of Post-Effective Amendment No. 2 to the Registration Statement on
         Form N-1A, filed on September 28, 1993.


<PAGE>

5(c).    Omnibus Selected Dealer Agreement between Morgan Stanley Dean Witter
         Distributors Inc. and National Financial Services Corporation, dated
         October 17, 1998 is incorporated by reference to Exhibit 5(c) of
         Post-Effective Amendment No. 9 to the Registration Statement on Form
         N-1A, filed on July 29, 1999.

6.       Amended Retirement Plan for Non-Interested Trustees or Directors, dated
         May 8, 1997 is incorporated by reference to Exhibit 6 of Post-Effective
         Amendment No. 9 to the Registration Statement on Form N-1A, filed on
         July 29, 1999.

7(a).    Custody Agreement between the Registrant and The Bank of New York,
         dated October 30, 1992, is incorporated by reference to Exhibit 8 of
         Post-Effective Amendment No. 4 to the Registration Statement on Form
         N-1A, filed on September 27, 1995.

7(b).    Amendment to the Custody Agreement between the Registrant and The Bank
         of New York, dated April 17, 1996, is incorporated by reference to
         Exhibit 8 of Post-Effective Amendment No. 5 to the Registration
         Statement on Form N-1A, filed on September 25, 1996.

8(a).    Amended and Restated Transfer Agency and Services Agreement between the
         Registrant and Morgan Stanley Dean Witter Trust FSB is incorporated by
         reference to Exhibit 8 of Post-Effective Amendment No. 8 to the
         Registration Statement on Form N-1A, filed on September 25, 1998.

8(b).    Amended Services Agreement between the Registrant and Morgan Stanley
         Dean Witter Service Company, dated June 22, 1998, is incorporated by
         reference to Exhibit 9 to Post-Effective Amendment No. 8 to the
         Registration Statement on Form N-1A, filed on September 25, 1998.

9(a).    Opinion of Sheldon Curtis, Esq., dated August 17, 1992 is incorporated
         by reference to Exhibit 10(a) of Pre-Effective Amendment No. 1 and
         Post-Effective Amendment No. 9 to the Registration Statement on Form
         N-1A, filed on July 29, 1999.

9(b).    Opinion of Lane Altman & Owens LLP, Massachusetts Counsel, dated August
         18, 1992 is incorporated by reference to Exhibit 9(b) of Post-Effective
         Amendment No. 9 to the Registration Statement on Form N-1A, filed on
         July 29, 1999.

10.      Consent of Independent Accountants, filed herein.

11.      Not applicable.

<PAGE>

12.      Not applicable.

13.      Amended and Restated Plan of Distribution pursuant to Rule 12b-1 is
         incorporated by reference to Exhibit 15 of Post-Effective Amendment No.
         6 to the Registration Statement on Form N-1A, filed on July 17, 1997.

Other.   Powers of Attorney of Trustees are incorporated by reference to Exhibit
         (Other) of Post-Effective Amendment No. 7 to the Registration Statement
         on Form N-1A, filed on September 29, 1997 and Post-Effective Amendment
         No. 3 to the Registration Statement on Form N-1A, filed on September
         28, 1994.

Item 24. Persons Controlled by or Under Common Control with the Fund.

                  None

Item 25. Indemnification.

     Pursuant to Section 5.3 of the Registrant's Declaration of Trust and under
Section 4.8 of the Registrant's By-Laws, the indemnification of the Registrant's
trustees, officers, employees and agents is permitted if it is determined that
they acted under the belief that their actions were in or not opposed to the
best interest of the Registrant, and, with respect to any criminal proceeding,
they had reasonable cause to believe their conduct was not unlawful. In
addition, indemnification is permitted only if it is determined that the actions
in question did not render them liable by reason of willful misfeasance, bad
faith or gross negligence in the performance of their duties or by reason of
reckless disregard of their obligations and duties to the Registrant. Trustees,
officers, employees and agents will be indemnified for the expense of litigation
if it is determined that they are entitled to indemnification against any
liability established in such litigation. The Registrant may also advance money
for these expenses provided that they give their undertakings to repay the
Registrant unless their conduct is later determined to permit indemnification.

             Pursuant to Section 5.2 of the Registrant's Declaration of Trust
and paragraph 8 of the Registrant's Investment Management Agreement, neither the
Investment Manager nor any trustee, officer, employee or agent of the Registrant
shall be liable for any action or failure to act, except in the case of bad
faith, willful misfeasance, gross negligence or reckless disregard of duties to
the Registrant.

             Insofar as indemnification for liabilities arising under the
Securities Act of 1933 (the "Act") may be permitted to trustees, officers and
controlling persons of the Registrant pursuant to the foregoing provisions or
otherwise, the Registrant has been advised that in the opinion of the Securities
and Exchange Commission such indemnification is against public policy as
expressed in the Act and is, therefore, unenforceable. In the event that a claim
for indemnification against such liabilities (other than the payment by the
Registrant of expenses incurred or paid by a trustee, officer, or controlling
person of the Registrant in connection with the successful defense of any
action, suit or proceeding) is asserted against the Registrant by such trustee,
officer or controlling person in connection with the shares being registered,
the Registrant will, unless in the opinion of its counsel the matter has been
settled by controlling

<PAGE>

precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the Act, and
will be governed by the final adjudication of such issue.

             The Registrant hereby undertakes that it will apply the
indemnification provision of its by-laws in a manner consistent with Release
11330 of the Securities and Exchange Commission under the Investment Company Act
of 1940, so long as the interpretation of Sections 17(h) and 17(i) of such Act
remains in effect.

             Registrant, in conjunction with the Investment Manager,
Registrant's Trustees, and other registered investment management companies
managed by the Investment Manager, maintains insurance on behalf of any person
who is or was a Trustee, officer, employee, or agent of Registrant, or who is or
was serving at the request of Registrant as a trustee, director, officer,
employee or agent of another trust or corporation, against any liability
asserted against him and incurred by him or arising out of his position.
However, in no event will Registrant maintain insurance to indemnify any such
person for any act for which Registrant itself is not permitted to indemnify
him.

Item 26. Business and Other Connections of Investment Advisor

         See "The Fund and Its Management" in the Prospectus regarding the
business of the investment advisor. The following information is given regarding
officers of Morgan Stanley Dean Witter Advisors Inc. ("MSDW Advisors"). MSDW
Advisors is a wholly-owned subsidiary of Morgan Stanley Dean Witter & Co.

         The term "Morgan Stanley Dean Witter Funds" refers to the following
registered investment companies:

Closed-End Investment Companies
(1)      Morgan Stanley Dean Witter California Insured Municipal Income Trust
(2)      Morgan Stanley Dean Witter California Quality Municipal Securities
(3)      Morgan Stanley Dean Witter Government Income Trust
(4)      Morgan Stanley Dean Witter High Income Advantage Trust
(5)      Morgan Stanley Dean Witter High Income Advantage Trust II
(6)      Morgan Stanley Dean Witter High Income Advantage Trust III
(7)      Morgan Stanley Dean Witter Income Securities Inc.
(8)      Morgan Stanley Dean Witter Insured California Municipal Securities
(9)      Morgan Stanley Dean Witter Insured Municipal Bond Trust
(10)     Morgan Stanley Dean Witter Insured Municipal Income Trust
(11)     Morgan Stanley Dean Witter Insured Municipal Securities
(12)     Morgan Stanley Dean Witter Insured Municipal Trust
(13)     Morgan Stanley Dean Witter Municipal Income Opportunities Trust
(14)     Morgan Stanley Dean Witter Municipal Income Opportunities Trust II
(15)     Morgan Stanley Dean Witter Municipal Income Opportunities Trust III
(16)     Morgan Stanley Dean Witter Municipal Income Trust
(17)     Morgan Stanley Dean Witter Municipal Income Trust II
(18)     Morgan Stanley Dean Witter Municipal Income Trust III
(19)     Morgan Stanley Dean Witter Municipal Premium Income Trust
(20)     Morgan Stanley Dean Witter New York Quality Municipal Securities
(21)     Morgan Stanley Dean Witter Prime Income Trust
(22)     Morgan Stanley Dean Witter Quality Municipal Income Trust

<PAGE>

(23)     Morgan Stanley Dean Witter Quality Municipal Investment Trust
(24)     Morgan Stanley Dean Witter Quality Municipal Securities

Open-end Investment Companies
(1)     Active Assets California Tax-Free Trust
(2)     Active Assets Government Securities Trust
(3)     Active Assets Money Trust
(4)     Active Assets Tax-Free Trust
(5)     Morgan Stanley Dean Witter Aggressive Equity Fund
(6)     Morgan Stanley Dean Witter American Opportunities Fund
(7)     Morgan Stanley Dean Witter Balanced Growth Fund
(8)     Morgan Stanley Dean Witter Balanced Income Fund
(9)     Morgan Stanley Dean Witter California Tax-Free Daily Income Trust
(10)    Morgan Stanley Dean Witter California Tax-Free Income Fund
(11)    Morgan Stanley Dean Witter Capital Growth Securities
(12)    Morgan Stanley Dean Witter Competitive Edge Fund, "Best Ideas Portfolio"
(13)    Morgan Stanley Dean Witter Convertible Securities Trust
(14)    Morgan Stanley Dean Witter Developing Growth Securities Trust
(15)    Morgan Stanley Dean Witter Diversified Income Trust
(16)    Morgan Stanley Dean Witter Dividend Growth Securities Inc.
(17)    Morgan Stanley Dean Witter Equity Fund
(18)    Morgan Stanley Dean Witter European Growth Fund Inc.
(19)    Morgan Stanley Dean Witter Federal Securities Trust
(20)    Morgan Stanley Dean Witter Financial Services Trust
(21)    Morgan Stanley Dean Witter Fund of Funds
(22)    Morgan Stanley Dean Witter Global Dividend Growth Securities
(23)    Morgan Stanley Dean Witter Global Utilities Fund
(24)    Morgan Stanley Dean Witter Growth Fund
(25)    Morgan Stanley Dean Witter Hawaii Municipal Trust
(26)    Morgan Stanley Dean Witter Health Sciences Trust
(27)    Morgan Stanley Dean Witter High Yield Securities Inc.
(28)    Morgan Stanley Dean Witter Income Builder Fund
(29)    Morgan Stanley Dean Witter Information Fund
(30)    Morgan Stanley Dean Witter Intermediate Income Securities
(31)    Morgan Stanley Dean Witter International Fund
(32)    Morgan Stanley Dean Witter International SmallCap Fund
(33)    Morgan Stanley Dean Witter Japan Fund
(34)    Morgan Stanley Dean Witter Latin American Growth Fund
(35)    Morgan Stanley Dean Witter Limited Term Municipal Trust
(36)    Morgan Stanley Dean Witter Liquid Asset Fund Inc.
(37)    Morgan Stanley Dean Witter Market Leader Trust
(38)    Morgan Stanley Dean Witter Mid-Cap Dividend Growth Securities
(39)    Morgan Stanley Dean Witter Mid-Cap Equity Trust
(40)    Morgan Stanley Dean Witter Multi-State Municipal Series Trust
(41)    Morgan Stanley Dean Witter Natural Resource Development Securities Inc.
(42)    Morgan Stanley Dean Witter New York Municipal Money Market Trust
(43)    Morgan Stanley Dean Witter New York Tax-Free Income Fund
(44)    Morgan Stanley Dean Witter North American Government Income Trust
(45)    Morgan Stanley Dean Witter Pacific Growth Fund Inc.
(46)    Morgan Stanley Dean Witter Precious Metals and Minerals Trust
(47)    Morgan Stanley Dean Witter Real Estate Fund

<PAGE>

(48)     Morgan Stanley Dean Witter S&P 500 Index Fund
(49)     Morgan Stanley Dean Witter S&P 500 Select Fund
(50)     Morgan Stanley Dean Witter Select Dimensions Investment Series
(51)     Morgan Stanley Dean Witter Select Municipal Reinvestment Fund
(52)     Morgan Stanley Dean Witter Short-Term Bond Fund
(53)     Morgan Stanley Dean Witter Short-Term U.S. Treasury Trust
(54)     Morgan Stanley Dean Witter Small Cap Growth Fund
(55)     Morgan Stanley Dean Witter Special Value Fund
(56)     Morgan Stanley Dean Witter Strategist Fund
(57)     Morgan Stanley Dean Witter Tax-Exempt Securities Trust
(58)     Morgan Stanley Dean Witter Tax-Free Daily Income Trust
(59)     Morgan Stanley Dean Witter Total Market Index Fund
(60)     Morgan Stanley Dean Witter Total Return Trust
(61)     Morgan Stanley Dean Witter U.S. Government Money Market Trust
(62)     Morgan Stanley Dean Witter U.S. Government Securities Trust
(63)     Morgan Stanley Dean Witter Utilities Fund
(64)     Morgan Stanley Dean Witter Value-Added Market Series
(65)     Morgan Stanley Dean Witter Value Fund
(66)     Morgan Stanley Dean Witter Variable Investment Series
(67)     Morgan Stanley Dean Witter World Wide Income Trust

NAME AND POSITION WITH              OTHER SUBSTANTIAL BUSINESS, PROFESSION,
MORGAN STANLEY DEAN                 VOCATION OR EMPLOYMENT, INCLUDING NAME,
WITTER ADVISORS INC.                PRINCIPAL ADDRESS AND NATURE OF CONNECTION
- --------------------                --------------------------------------------

Mitchell M. Merin                   President and Chief Operating Officer of
President, Chief                    Asset Management of Morgan Stanley Dean
Executive Officer and               Witter & Co. ("MSDW); Chairman, Chief
Director                            Executive Officer and Director of Morgan
                                    Stanley Dean Witter Distributors Inc. ("MSDW
                                    Distributors") and Morgan Stanley Dean
                                    Witter Trust FSB ("MSDW Trust"); President,
                                    Chief Executive Officer and Director of
                                    Morgan Stanley Dean Witter Services Company
                                    Inc. ("MSDW Services"); President of the
                                    Morgan Stanley Dean Witter Funds and
                                    Discover Brokerage Index Series; Executive
                                    Vice President and Director of Dean Witter
                                    Reynolds Inc. ("DWR"); Director of various
                                    MSDW subsidiaries.

Joseph J. McAlinden                 Vice President of the Morgan Stanley Dean
Executive Vice President            Witter Funds and Discover Brokerage Index
and Chief Investment                Series; Director of MSDW Trust.
Officer

Ronald E. Robison                   President MSDW Trust; Executive Vice
Executive Vice President,           President, Chief Administrative Officer and
Chief Administrative                Director of MSDW Services; Vice President of
Officer and Director                the Morgan Stanley Dean Witter Funds and
                                    Discover Brokerage Index Series.

<PAGE>
NAME AND POSITION WITH              OTHER SUBSTANTIAL BUSINESS, PROFESSION,
MORGAN STANLEY DEAN                 VOCATION OR EMPLOYMENT, INCLUDING NAME,
WITTER ADVISORS INC.                PRINCIPAL ADDRESS AND NATURE OF CONNECTION
- --------------------                --------------------------------------------

Edward C. Oelsner, III
Executive Vice President

Barry Fink                          Assistant Secretary of DWR; Senior Vice
Senior Vice President,              President, Secretary, General Counsel and
Secretary, General                  Director of MSDW Services; Senior Vice
Counsel and Director                President, Assistant Secretary and Assistant
                                    General Counsel of MSDW Distributors; Vice
                                    President, Secretary and General Counsel of
                                    the Morgan Stanley Dean Witter Funds and
                                    Discover Brokerage Index Series.

Peter M. Avelar                     Vice President of various Morgan Stanley
Senior Vice President               Dean Witter Funds.
and Director of the High
Yield Group

Mark Bavoso                         Vice President of various Morgan Stanley
Senior Vice President               Dean Witter Funds.

Douglas Brown
Senior Vice President

Rosalie Clough
Senior Vice President
and Director of Marketing

Richard Felegy
Senior Vice President

Edward F. Gaylor                    Vice President of various Morgan Stanley
Senior Vice President               Dean Witter Funds.

Robert S. Giambrone                 Senior Vice President of MSDW Services, MSDW
Senior Vice President               Distributors and MSDW Trust and Director of
                                    MSDW Trust; Vice President of the Morgan
                                    Stanley Dean Witter Funds and Discover
                                    Brokerage Index Series.

Rajesh K. Gupta                     Vice President of various Morgan Stanley
Senior Vice President,              Dean Witter Funds.
Director of the Taxable
Fixed Income Group and
Chief Administrative Officer -
Investments

Kenton J. Hinchliffe                Vice President of various Morgan Stanley
Senior Vice President               Dean Witter Funds and Discover Brokerage
                                    Index Series.


<PAGE>

NAME AND POSITION WITH              OTHER SUBSTANTIAL BUSINESS, PROFESSION,
MORGAN STANLEY DEAN                 VOCATION OR EMPLOYMENT, INCLUDING NAME,
WITTER ADVISORS INC.                PRINCIPAL ADDRESS AND NATURE OF CONNECTION
- --------------------                --------------------------------------------

Kevin Hurley                        Vice President of various Morgan Stanley
Senior Vice President               Dean Witter Funds.

Jenny Beth Jones                    Vice President of various Morgan Stanley
Senior Vice President               Dean Witter Funds.

Michelle Kaufman                    Vice President of various Morgan Stanley
Senior Vice President               Dean Witter Funds.

John B. Kemp, III                   President of MSDW Distributors.
Senior Vice President

Anita H. Kolleeny                   Vice President of various Morgan Stanley
Senior Vice President               Dean Witter Funds.
and Director of Sector
Rotation

Jonathan R. Page                    Vice President of various Morgan Stanley
Senior Vice President               Dean Witter Funds.
and Director of the Money
Market Group

Ira N. Ross                         Vice President of various Morgan Stanley
Senior Vice President               Dean Witter Funds.

Guy G. Rutherfurd, Jr.              Vice President of various Morgan Stanley
Senior Vice President               Dean Witter Funds.
and Director of the Growth
Group

Rochelle G. Siegel                  Vice President of various Morgan Stanley
Senior Vice President               Dean Witter Funds.

James Solloway
Senior Vice President

Paul D. Vance                       Vice President of various Morgan Stanley
Senior Vice President               Dean Witter Funds.
and Director of the Growth
and Income Group

Elizabeth A. Vetell
Senior Vice President
and Director of Shareholder
Communication


<PAGE>

NAME AND POSITION WITH              OTHER SUBSTANTIAL BUSINESS, PROFESSION,
MORGAN STANLEY DEAN                 VOCATION OR EMPLOYMENT, INCLUDING NAME,
WITTER ADVISORS INC.                PRINCIPAL ADDRESS AND NATURE OF CONNECTION
- --------------------                --------------------------------------------

James F. Willison                   Vice President of various Morgan Stanley
Senior Vice President               Dean Witter Funds.
and Director of the
Tax-Exempt Fixed
Income Group

Frank Bruttomesso                   First Vice President and Assistant Secretary
First Vice President                of MSDW and Services; Assistant Secretary of
Assistant Secretary                 MSDW Distributors, the Morgan Stanley Dean
                                    Witter Funds and Discover Brokerage Index
                                    Series.

Thomas F. Caloia                    First Vice President and Assistant Treasurer
First Vice President                of MSDW Services; Assistant Treasurer of
and Assistant                       MSDW Distributors; Treasurer and Chief
Treasurer                           Financial and Accounting Officer of the
                                    Morgan Stanley Dean Witter Funds and
                                    Discover Brokerage Index Series.

Thomas Chronert
First Vice President

Marilyn K. Cranney                  Assistant Secretary of DWR; First Vice
First Vice President                President and Assistant Secretary of MSDW
and Assistant Secretary             Services; Assistant Secretary of MSDW
                                    Distributors, the Morgan Stanley Dean Witter
                                    Funds and Discover Brokerage Index Series.

Salvatore DeSteno                   First Vice President of MSDW Services.
First Vice President

Peter W. Gurman
First Vice President

Michael Interrante                  First Vice President and Controller of MSDW
First Vice President                Services; Assistant Treasurer of MSDW
and Controller                      Distributors; First Vice  President and
                                    Treasurer of MSDW Trust.

David Johnson
First Vice President

Stanley Kapica
First Vice President

Lou Anne D. McInnis                 First Vice President and Assistant Secretary
First Vice President and            of MSDW Services; Assistant Secretary of
Assistant Secretary                 MSDW Distributors, the Morgan Stanley Dean
                                    Witter Funds and Discover Brokerage Index
                                    Series.

<PAGE>

NAME AND POSITION WITH              OTHER SUBSTANTIAL BUSINESS, PROFESSION,
MORGAN STANLEY DEAN                 VOCATION OR EMPLOYMENT, INCLUDING NAME,
WITTER ADVISORS INC.                PRINCIPAL ADDRESS AND NATURE OF CONNECTION
- --------------------                --------------------------------------------

Carsten Otto                        First Vice President and Assistant Secretary
First Vice President                of MSDW Services; Assistant Secretary of
and Assistant Secretary             MSDW Distributors, the Morgan Stanley Dean
                                    Witter Funds and Discover Brokerage Index
                                    Series.

Ruth Rossi                          First Vice President and Assistant Secretary
First Vice President                of MSDW Services; Assistant Secretary of
and Assistant Secretary             MSDW Distributors, the Morgan Stanley Dean
                                    Witter Funds and Discover Brokerage Index
                                    Series.

James P. Wallin
First Vice President

Robert Abreu
Vice President

Dale Albright
Vice President

Joan G. Allman
Vice President

Andrew Arbenz
Vice President

Joseph Arcieri                      Vice President of various Morgan Stanley
Vice President                      Dean Witter Funds.

Armon Bar-Tur                       Vice President of various Morgan Stanley
Vice President                      Dean Witter Funds.

Raymond Basile
Vice President

Nancy Belza
Vice President

Maurice Bendrihem
Vice President and
Assistant Controller

Dale Boettcher
Vice President

Ronald Caldwell
Vice President

<PAGE>

NAME AND POSITION WITH              OTHER SUBSTANTIAL BUSINESS, PROFESSION,
MORGAN STANLEY DEAN                 VOCATION OR EMPLOYMENT, INCLUDING NAME,
WITTER ADVISORS INC.                PRINCIPAL ADDRESS AND NATURE OF CONNECTION
- --------------------                --------------------------------------------

Joseph Cardwell
Vice President

Liam Carroll
Vice President

Philip Casparius
Vice President

Aaron Clark
Vice President

William Connerly
Vice President

David Dineen
Vice President

Sheila Finnerty                     Vice President of Morgan Stanley Dean
Vice President                      Witter Prime Income Trust

Jeffrey D. Geffen
Vice President

Sandra Gelpieryn
Vice President

Charmaine George
Vice President

Michael Geringer
Vice President

Gail Gerrity
Vice President

Ellen Gold
Vice President

Stephen Greenhut
Vice President

Trey Hancock
Vice President

Matthew Haynes                      Vice President of various Morgan Stanley
Vice President                      Dean Witter Funds.
<PAGE>

NAME AND POSITION WITH              OTHER SUBSTANTIAL BUSINESS, PROFESSION,
MORGAN STANLEY DEAN                 VOCATION OR EMPLOYMENT, INCLUDING NAME,
WITTER ADVISORS INC.                PRINCIPAL ADDRESS AND NATURE OF CONNECTION
- --------------------                --------------------------------------------

Peter Hermann                       Vice President of various Morgan Stanley
Vice President                      Dean Witter Funds.

David T. Hoffman
Vice President

Kevin Jung                          Vice President of various Morgan Stanley
Vice President                      Dean Witter Funds.

Carol Espejo-Kane
Vice President

Nancy Karole-Kennedy
Vice President

Doug Ketterer
Vice President

Paula LaCosta                       Vice President of various Morgan Stanley
Vice President                      Dean Witter Funds.

Kimberly LaHart
Vice President

Thomas Lawlor
Vice President

Todd Lebo                           Vice President and Assistant Secretary of
Vice President and                  MSDW Services; Assistant Secretary of MSDW
Assistant Secretary                 Distributors, the Morgan Stanley Dean Witter
                                    Funds and Discover Brokerage Index Series.

Gerard J. Lian                      Vice President of various Morgan Stanley
Vice President                      Dean Witter Funds.

Nancy Login
Vice President

Sharon Loguercio
Vice President

Steven MacNamara
Vice President

Catherine Maniscalco                Vice President of various Morgan Stanley
Vice President                      Dean Witter Funds.

<PAGE>

NAME AND POSITION WITH              OTHER SUBSTANTIAL BUSINESS, PROFESSION,
MORGAN STANLEY DEAN                 VOCATION OR EMPLOYMENT, INCLUDING NAME,
WITTER ADVISORS INC.                PRINCIPAL ADDRESS AND NATURE OF CONNECTION
- --------------------                --------------------------------------------

Albert McGarity
Vice President

Teresa McRoberts                    Vice President of Morgan Stanley Dean Witter
Vice President                      S&P 500 Select Fund.

Mark Mitchell
Vice President

Julie Morrone                       Vice President of various Morgan Stanley
Vice President                      Dean Witter Funds.

Mary Beth Mueller
Vice President

David Myers                         Vice President of Morgan Stanley Dean Witter
Vice President                      Natural Resource Development Securities Inc.

James Nash
Vice President

Richard Norris
Vice President

Anne Pickrell
Vice President

Dawn Rorke
Vice President

John Roscoe                         Vice President of Morgan Stanley Dean Witter
Vice President                      Real Estate Fund

Hugh Rose
Vice President

Robert Rossetti                     Vice President of various Morgan Stanley
Vice President                      Dean Witter Funds.

Carl F. Sadler
Vice President

Deborah Santaniello
Vice President

Patrice Saunders
Vice President
<PAGE>

NAME AND POSITION WITH              OTHER SUBSTANTIAL BUSINESS, PROFESSION,
MORGAN STANLEY DEAN                 VOCATION OR EMPLOYMENT, INCLUDING NAME,
WITTER ADVISORS INC.                PRINCIPAL ADDRESS AND NATURE OF CONNECTION
- --------------------                --------------------------------------------

Howard A. Schloss                   Vice President of Morgan Stanley Dean Witter
Vice President                      Federal Securities Trust.

Peter J. Seeley                     Vice President of various Morgan Stanley
Vice President                      Dean Witter Funds.

Robert Stearns
Vice President

Naomi Stein
Vice President

Michael Strayhorn
Vice President

Kathleen H. Stromberg               Vice President of various Morgan Stanley
Vice President                      Dean Witter Funds.

Marybeth Swisher
Vice President

Michael Thayer
Vice President

Robert Vanden Assem
Vice President

David Walsh
Vice President

Alice Weiss                         Vice President of various Morgan Stanley
Vice President                      Dean Witter Funds.

John Wong
Vice President

         The principal address of MSDW Advisors, MSDW Services, MSDW
Distributors, DWR, the Morgan Stanley Dean Witter Funds and Discover Brokerage
Index Series is Two World Trade Center, New York, New York 10048. The principal
address of MSDW is 1585 Broadway, New York, New York 10036. The principal
address of MSDW Trust is 2 Harborside Financial Center, Jersey City, New Jersey
07311.

Item 27. Principal Underwriters

(a) Morgan Stanley Dean Witter Distributors Inc. ("MSDW Distributors"), a
Delaware corporation, is the principal underwriter of the Registrant. MSDW
Distributors is also the principal underwriter of the following investment
companies:

<PAGE>

(1)      Active Assets California Tax-Free Trust
(2)      Active Assets Government Securities Trust
(3)      Active Assets Money Trust
(4)      Active Assets Tax-Free Trust
(5)      Morgan Stanley Dean Witter Aggressive Equity Fund
(6)      Morgan Stanley Dean Witter American Opportunities Fund
(7)      Morgan Stanley Dean Witter Balanced Growth Fund
(8)      Morgan Stanley Dean Witter Balanced Income Fund
(9)      Morgan Stanley Dean Witter California Tax-Free Daily Income Trust
(10)     Morgan Stanley Dean Witter California Tax-Free Income Fund
(11)     Morgan Stanley Dean Witter Capital Growth Securities
(12)     Morgan Stanley Dean Witter Competitive Edge Fund, "Best Ideas
         Portfolio"
(13)     Morgan Stanley Dean Witter Convertible Securities Trust
(14)     Morgan Stanley Dean Witter Developing Growth Securities Trust
(15)     Morgan Stanley Dean Witter Diversified Income Trust
(16)     Morgan Stanley Dean Witter Dividend Growth Securities Inc.
(17)     Morgan Stanley Dean Witter Equity Fund
(18)     Morgan Stanley Dean Witter European Growth Fund Inc.
(19)     Morgan Stanley Dean Witter Federal Securities Trust
(20)     Morgan Stanley Dean Witter Financial Services Trust
(21)     Morgan Stanley Dean Witter Fund of Funds
(22)     Morgan Stanley Dean Witter Global Dividend Growth Securities
(23)     Morgan Stanley Dean Witter Global Utilities Fund
(24)     Morgan Stanley Dean Witter Growth Fund
(25)     Morgan Stanley Dean Witter Hawaii Municipal Trust
(26)     Morgan Stanley Dean Witter Health Sciences Trust
(27)     Morgan Stanley Dean Witter High Yield Securities Inc.
(28)     Morgan Stanley Dean Witter Income Builder Fund
(29)     Morgan Stanley Dean Witter Information Fund
(30)     Morgan Stanley Dean Witter Intermediate Income Securities
(31)     Morgan Stanley Dean Witter International Fund
(32)     Morgan Stanley Dean Witter International SmallCap Fund
(33)     Morgan Stanley Dean Witter Japan Fund
(34)     Morgan Stanley Dean Witter Latin American Growth Fund
(35)     Morgan Stanley Dean Witter Limited Term Municipal Trust
(36)     Morgan Stanley Dean Witter Liquid Asset Fund Inc.
(37)     Morgan Stanley Dean Witter Market Leader Trust
(38)     Morgan Stanley Dean Witter Mid-Cap Dividend Growth Securities
(39)     Morgan Stanley Dean Witter Mid-Cap Equity Trust
(40)     Morgan Stanley Dean Witter Multi-State Municipal Series Trust
(41)     Morgan Stanley Dean Witter Natural Resource Development Securities Inc.
(42)     Morgan Stanley Dean Witter New York Municipal Money Market Trust
(43)     Morgan Stanley Dean Witter New York Tax-Free Income Fund
(44)     Morgan Stanley Dean Witter North American Government Income Trust
(45)     Morgan Stanley Dean Witter Pacific Growth Fund Inc.
(46)     Morgan Stanley Dean Witter Precious Metals and Minerals Trust
(47)     Morgan Stanley Dean Witter Prime Income Trust
(48)     Morgan Stanley Dean Witter Real Estate Fund
(49)     Morgan Stanley Dean Witter S&P 500 Index Fund
(50)     Morgan Stanley Dean Witter S&P 500 Select Fund

<PAGE>

(51)     Morgan Stanley Dean Witter Short-Term Bond Fund
(52)     Morgan Stanley Dean Witter Short-Term U.S. Treasury Trust
(53)     Morgan Stanley Dean Witter Small Cap Growth Fund
(54)     Morgan Stanley Dean Witter Special Value Fund
(55)     Morgan Stanley Dean Witter Strategist Fund
(56)     Morgan Stanley Dean Witter Tax-Exempt Securities Trust
(57)     Morgan Stanley Dean Witter Tax-Free Daily Income Trust
(58)     Morgan Stanley Dean Witter Total Market Index Fund
(59)     Morgan Stanley Dean Witter Total Return Trust
(60)     Morgan Stanley Dean Witter U.S. Government Money Market Trust
(61)     Morgan Stanley Dean Witter U.S. Government Securities Trust
(62)     Morgan Stanley Dean Witter Utilities Fund
(63)     Morgan Stanley Dean Witter Value-Added Market Series
(64)     Morgan Stanley Dean Witter Value Fund
(65)     Morgan Stanley Dean Witter Variable Investment Series
(66)     Morgan Stanley Dean Witter World Wide Income Trust

(b) The following information is given regarding directors and officers of MSDW
Distributors not listed in Item 26 above. The principal address of MSDW
Distributors is Two World Trade Center, New York, New York 10048. Other than Mr.
Purcell, who is a Trustee of the Registrant, none of the following persons has
any position or office with the Registrant.

Name                       Positions and Office with MSDW Distributors
- ----                       -------------------------------------------
Michael T. Gregg           Vice President and Assistant Secretary.

James F. Higgins           Director

Fredrick K. Kubler         Senior Vice President, Assistant Secretary and Chief
                           Compliance Officer.

Philip J. Purcell          Director

John Schaeffer             Director

Charles Vadala             Senior Vice President and Financial Principal.

Item 28. Location of Accounts and Records

      All accounts, books and other documents required to be maintained by
Section 31(a) of the Investment Company Act of 1940 and the Rules thereunder are
maintained by the Investment Manager at its offices, except records relating to
holders of shares issued by the Registrant, which are maintained by the
Registrant's Transfer Agent, at its place of business as shown in the
prospectus.

Item 29. Management Services

      Registrant is not a party to any such management-related service contract.
<PAGE>

Item 30. Undertakings

         Registrant hereby undertakes to furnish each person to whom a
prospectus is delivered with a copy of the Registrant's latest annual report to
shareholders, upon request and without charge.


<PAGE>



                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933 and the
Investment Company Act of 1940, the Registrant certifies that it meets all of
the requirements for effectiveness of this Registration Statement pursuant to
Rule 485(b) under the Securities Act of 1933 and has duly caused this
Post-Effective Amendment to the Registration Statement to be signed on its
behalf by the undersigned, thereunto duly authorized, in the City of New York
and State of New York on the 24th day of September, 1999.

                                MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST

                                              By /s/ Barry Fink
                                                --------------------------------
                                                 Barry Fink
                                                 Vice President and Secretary

         Pursuant to the requirements of the Securities Act of 1933, this
Post-Effective Amendment No. 10 has been signed below by the following persons
in the capacities and on the dates indicated.

         Signatures                              Title                   Date
         ----------                              -----                   ----
(1) Principal Executive Officer         Chief Executive Officer,
                                        Trustee and Chairman
By /s/ Charles A. Fiumefreddo                                          9/24/99
  -----------------------
       Charles A. Fiumefreddo

(2) Principal Financial Officer         Treasurer and Principal
                                        Accounting Officer

By /s/ Thomas F. Caloia                                                9/24/99
  -----------------------
       Thomas F. Caloia

(3) Majority of the Trustees

    Charles A. Fiumefreddo (Chairman)
    Philip J. Purcell

By /s/ Barry Fink                                                      9/24/99
  -----------------------
       Barry Fink
       Attorney-in-Fact

    Michael Bozic    Manuel H. Johnson
    Edwin J. Garn    Michael E. Nugent
    Wayne E. Hedien  John L. Schroeder


By /s/ David M. Butowsky                                               9/24/99
  -----------------------
       David M. Butowsky
       Attorney-in-Fact

<PAGE>







                MORGAN STANLEY DEAN WITTER HEALTH SCIENCES TRUST
                                  EXHIBIT INDEX


10.      Consent of Independent Accountants




<PAGE>

CONSENT OF INDEPENDENT ACCOUNTANTS

We hereby consent to the use in the Statement of Additional Information
constituting part of this Post-Effective Amendment No. 10 to the registration
statement on Form N-1A (the "Registration Statement") of our report dated
September 9, 1999, relating to the financial statements and financial highlights
of Morgan Stanley Dean Witter Health Sciences Trust, which appears in such
Statement of Additional Information, and to the incorporation by reference of
our report into the Prospectus which constitutes part of this Registration
Statement. We also consent to the references to us under the headings "Custodian
and Independent Accountants" and "Experts" in such Statement of Additional
Information and to the reference to us under the heading "Financial Highlights"
in such Prospectus.




PricewaterhouseCoopers LLP
1177 Avenue of the Americas
New York, New York 10036
September 24, 1999



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