METRA BIOSYSTEMS INC
S-8, 1997-12-17
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>

     As filed with the Securities and Exchange Commission on December 17, 1997
                                               Registration No. 333-__________
- ------------------------------------------------------------------------------
- ------------------------------------------------------------------------------



                      SECURITIES AND EXCHANGE COMMISSION
                           WASHINGTON, D.C. 20549
                              ________________
                                           
                                 FORM S-8
                                           
                           REGISTRATION STATEMENT
                                   UNDER
                         THE SECURITIES ACT OF 1933
                              ________________
                                         
                            METRA BIOSYSTEMS, INC.
            (Exact name of Registrant as specified in its charter)

       CALIFORNIA                                    33-0408436
(State of Incorporation)                  (I.R.S. Employer Identification No.)

                          265 NORTH WHISMAN ROAD
                       MOUNTAIN VIEW, CA  94043-3911
                  (Address of principal executive offices)
                            _______________________

                            1995 STOCK OPTION PLAN
                           (Full title of the Plan)
                            _______________________

                             GEORGE W. DUNBAR, JR.
                     PRESIDENT AND CHIEF EXECUTIVE OFFICER
                            265 NORTH WHISMAN ROAD
                         MOUNTAIN VIEW, CA  94043-3911
                                (650) 903-9100
(Name, address and telephone number, including area code, of agent for service)
                            _______________________
                                   Copy to:

                                 Mark B. Weeks
                               Venture Law Group
                              2800 Sand Hill Road
                          Menlo Park, California 94025
                                (650) 854-4488

                              Page 1 of 11 Pages
                           Exhibit Index on Page 8
               (Calculation of Registration Fee on following page)
<PAGE>

- ------------------------------------------------------------------------------
                     CALCULATION OF REGISTRATION FEE
- ------------------------------------------------------------------------------
<TABLE>
<CAPTION>
                                                             Proposed         Proposed
                                           Maximum            Maximum          Maximum          Amount of
                                         Amount to be      Offering Price      Aggregate       Registration
Title of Securities to be Registered      Registered          Per Share      Offering Price         Fee
- -------------------------------------------------------------------------------------------------------------
<S>                                     <C>                   <C>            <C>                  <C>
1995 STOCK OPTION PLAN
Common Stock,
$0.01 par value ...........             540,115 Shares (1)    $3.8125 (2)    $2,059,188.40 (2)    $607.46 (2)

Common Stock,
$0.01 par value ...........             259,885 Shares (1)    $4.90 (3)      $1,273,436.50 (3)    $375.66 (3)


             TOTAL                      800,000 Shares                       $3,332,624.90        $983.12
- -------------------------------------------------------------------------------------------------------------
</TABLE>


_______________________
(1) Registrant is registering an aggregate of 800,000 shares under its 1995
    Stock Option Plan pursuant to this Registration Statement.  This aggregate
    number represents increases in the shares reserved for issuance under
    Registrant's 1995 Stock Option Plan, 500,000 shares of which were approved
    by Registrant's shareholders at a meeting held on December 16, 1996 and
    300,000 shares of which were approved by Registrant's shareholders at a
    meeting held on December 8, 1997.  Of the 800,000 shares covered by this
    increase, as of December 8, 1997, 259,885 shares are subject to outstanding
    options.  An additional 1,000,000 shares were previously registered for
    issuance under the 1995 Stock Option Plan pursuant to a previous Form S-8
    filed by Registrant with the Securities and Exchange Commission (the
    "COMMISSION") on November 13, 1995 (Registration No. 33-99200).


(2) Computed in accordance with Rule 457(h) under the Securities Act  of 1933,
    as amended (the "SECURITIES ACT") solely for the purpose of calculating the
    registration fee.  The computation with respect to unissued options is
    based upon the average high and low sale prices of the Common Stock as
    reported on the Nasdaq National Market on December 15, 1997.

(3) Computed in accordance with Rule 457(h) under the Securities Act solely for
    the purpose of calculating the registration fee.  The computation with
    respect to issued options is based on the weighted average per share
    exercise price of outstanding options under the referenced Plan, the shares
    issuable under which are registered hereby.


                                     -2-
<PAGE>

                                   PART II
              INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE

    The following documents filed by Registrant with the Commission are 
incorporated by reference:

    1.  Registrant's Annual Report on Form 10-K for the year ended June 30,
1997 (File No. 0-26234).

    2.  Registrant's definitive Proxy Statement dated November 10, 1997, 
filed in connection with the Registrant's December 8, 1997 Annual Meeting of 
Shareholders.

    3.  Registrant's Quarterly Report on Form 10-Q for the quarter ended 
September 30, 1997, (File No. 0-26234).

    4.  The description of Registrant's Common Stock set forth in Registrant's
Registration Statement on Form 8-A, filed with the Commission on June 13, 1995
(File No. 0-26234).

    5.  The description of Registrant's Preferred Share Purchase Rights set
forth in Registrant's Registration Statement on Form 8-A/A, filed with the
Commission on January 27, 1997 (File No. 0-26234).

    6.  Registrant's Registration Statement on Form S-8, filed on November 13,
1995 (File No. 33-99200).

    All documents filed by Registrant pursuant to Sections 13(a), 13(c), 14 
or 15(d) of the Securities Exchange Act of 1934, as amended (the "EXCHANGE 
ACT") after the date hereof, and prior to the filing of a post-effective 
amendment which indicates that all securities offered hereunder have been 
sold or which deregisters all securities then remaining unsold under this 
registration statement, shall be deemed to be incorporated by reference 
herein and to be part hereof from the date of filing of such document.  Any 
statement contained in a document incorporated by reference herein shall be 
deemed to be modified or superseded for purposes hereof to the extent that a 
statement contained herein (or in any other subsequently filed document which 
also is incorporated by reference herein) modifies or supersedes such 
statement.  Any such statement so modified or superseded shall not be deemed 
to constitute a part hereof, except as so modified or superseded. 

ITEM 4.  DESCRIPTION OF SECURITIES

    Not applicable.

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL

    Not applicable.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS

    The Company's Articles of Incorporation limit the liability of directors 
for monetary damages arising from breach of their fiduciary duty to the 
maximum extent permitted by the California Corporations Code ("California 
Law").  Such limitation of liability does not affect the availability of 
equitable remedies such as injunctive relief or recession.  The limitation on 
monetary liability also does not apply to liabilities arising under the 
federal securities laws.

    The Company's Bylaws provide that the Company shall indemnify its 
directors and officers to the fullest extent permitted by California law, 
including circumstances in which indemnification is otherwise discretionary 
under California law.  The Company has entered into indemnification 
agreements with its directors containing provision which are in some respects 
broader than the specific indemnification provisions contained in the 


                                     -3-
<PAGE>

California Corporations Code.  The indemnification agreements may require the 
Company, among other things, to indemnify its directors against certain 
liabilities that may arise by reason of their status or service as directors 
(other than liabilities arising from willful misconduct of a culpable 
nature), to advance their expenses incurred as a result of any proceeding 
against them as to which they could be indemnified, and to obtain director's 
insurance if available on reasonable terms.

    The Company believes that the limitation provision in its Articles of 
Incorporation and the indemnification provisions in its Articles of 
Incorporation, Bylaws and indemnification agreements will facilitate the 
Company's ability to continue to attract and retain qualified individuals to 
serve as directors of the Company.  It is the opinion of the Commission that 
indemnification provisions such as those contained in the Bylaws and these 
agreements have no effect on a director's or officer's liability under the 
federal securities laws.

    The Registrant has also obtained directors and officers' liability 
insurance covering, subject to certain exceptions, actions taken by the 
Registrant's directors and officers in their capacities as such.

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED

    Not applicable.

ITEM 8.  EXHIBITS

   Exhibit
   Number
   -------
     4.1*  1995 Stock Option Plan, and form of agreement thereunder

     5.1   Opinion of Venture Law Group, a Professional Corporation (see p. 9).

    23.1   Consent of Venture Law Group, a Professional Corporation 
           (included in Exhibit 5.1).

    23.2   Consent of Ernst & Young LLP, Independent Auditors (see p. 10).

    23.3   Consent of KPMG Peat Marwick LLP, Independent Auditors (see p. 11).

    24.1   Powers of Attorney (see p. 7).

_______________
*  Incorporated by reference from Registrant's Registration Statement on Form 
S-1, as amended, filed with the Commission on June 29, 1995.

ITEM 9.  UNDERTAKINGS

    The undersigned Registrant hereby undertakes:

       (1)  To file, during any period in which offers or sales are being 
made, a post-effective amendment to this Registration Statement to include 
any material information with respect to the plan of distribution not 
previously disclosed in the Registration Statement or any material change to 
such information in the Registration Statement.

       (2)  That, for the purpose of determining any liability under the 
Securities Act, each such post-effective amendment shall be deemed to be a 
new registration statement relating to the securities offered therein, and 
the offering of such securities at that time shall be deemed to be the 
initial bona fide offering thereof.


                                     -4-
<PAGE>

       (3)  To remove from registration by means of a post-effective 
amendment any of the securities being registered which remain unsold at the 
termination of this offering.

       (4)  That, for purposes of determining any liability under the 
Securities Act, each filing of Registrant's annual report pursuant to Section 
13(a) or Section 15(d) of the Exchange Act that is incorporated by reference 
in the Registration Statement shall be deemed to be a new registration 
statement relating to the securities offered therein, and the offering of 
such securities at that time shall be deemed to be the initial bona fide 
offering thereof.

    Insofar as indemnification for liabilities arising under the Securities 
Act may be permitted to directors, officers and controlling persons of 
Registrant pursuant to the foregoing provisions, or otherwise, Registrant has 
been advised that in the opinion of the SEC such indemnification is against 
public policy as expressed in the Securities Act and is, therefore, 
unenforceable.  In the event that a claim for indemnification against such 
liabilities (other than the payment by Registrant of expenses incurred or 
paid by a director, officer or controlling person of Registrant in the 
successful defense of any action, suit or proceeding) is asserted by such 
director, officer or controlling person in connection with the securities 
being registered, Registrant will, unless in the opinion of its counsel the 
matter has been settled by controlling precedent, submit to a court of 
appropriate jurisdiction the question whether such indemnification by it is 
against public policy as expressed in the Securities Act and will be governed 
by the final adjudication of such issue.


                           [Signature Pages Follow]


                                     -5-
<PAGE>

                                 SIGNATURES


     Pursuant to the requirements of the Securities Act of 1933, Registrant, 
Metra Biosystems, Inc., a corporation organized and existing under the laws 
of the State of California, certifies that it has reasonable grounds to 
believe that it meets all of the requirements for filing on Form S-8 and has 
duly caused this Registration Statement to be signed on its behalf by the 
undersigned, thereunto duly authorized, in the City of Mountain View, State 
of California, on December 8, 1997.


                                   METRA BIOSYSTEMS, INC.


                                   By:  /s/ GEORGE W. DUNBAR, JR.
                                       ------------------------------
                                        George W. Dunbar, Jr.
                                        President and Chief Executive Officer


                                     -6-
<PAGE>

                               POWER OF ATTORNEY

     KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature 
appears below constitutes and appoints George W. Dunbar, Jr. and Kurt E. 
Amundson, jointly and severally, his attorneys-in-fact and agents, each with 
the power of substitution and resubstitution, for him and in his name, place 
or stead, in any and all capacities, to sign any amendments to this 
Registration Statement on Form S-8, and to file such amendments, together 
with exhibits and other documents in connection therewith, with the 
Securities and Exchange Commission, granting to each attorney-in-fact and 
agent, full power and authority to do and perform each and every act and 
thing requisite and necessary to be done in and about the premises, as fully 
as he might or could do in person, and ratifying and confirming all that the 
attorneys-in-fact and agents, or his substitute or substitutes, may do or 
cause to be done by virtue hereof.

     Pursuant to the requirements of the Securities Act of 1933, this 
Registration Statement has been signed by the following persons in the 
capacities and on the dates indicated.

<TABLE>
<CAPTION>
        Signature                                 Title                          Date 
        ---------                                 -----                          ---- 
<S>                                  <C>                                    <C>       

/s/ George W. Dunbar, Jr.                                                             
- ----------------------------         President, Chief Executive Officer     December 15, 1997 
George W. Dunbar, Jr.

/s/ Kurt E. Amundson                 Vice President and Chief Financial
- ----------------------------          Officer (Principal Financial and      December 15, 1997 
Kurt E. Amundson                      Accounting Officer)                                     

/s/ Claude D. Arnaud, M.D.
- ----------------------------         Director                               December 15, 1997 
Claude D. Arnaud, M.D.

/s/ John L. Castello
- ----------------------------         Director                               December 15, 1997 
John L. Castello                                                                              

/s/ Mary Lake Polan, M.D., Ph.D.
- ----------------------------         Director                               December 15, 1997 
Mary Lake Polan, M.D., Ph.D.

/s/ Craig C. Taylor 
- ----------------------------         Director                               December 15, 1997
Craig C. Taylor 
</TABLE>


                                     -7-
<PAGE>

                              INDEX TO EXHIBITS

Exhibit                                                                  Page
Number                                                                    No.
- -------                                                                  ----

      
 4.1*   1995 Stock Option Plan, and form of agreement thereunder          --

 5.1    Opinion of Venture Law Group, a Professional Corporation.          9

23.1    Consent of Venture Law Group, a Professional Corporation           9
        (included in Exhibit 5.1).  

23.2    Consent of Ernst & Young LLP, Independent Auditors.               10

23.3    Consent of KPMG Peat Marwick LLP, Independent Auditors.           11

24.1    Powers of Attorney (see page 7).                                   7

_______________
*  Incorporated by reference from Registrant's Registration Statement on 
Form S-1, as amended, filed with the Commission on June 29, 1995.


<PAGE>

                                                                   EXHIBIT 5.1

                                  OPINION OF COUNSEL


                                  December 17, 1997
                                           
Metra Biosystems, Inc.
265 N. Whisman Road
Mountain View, CA 94043-3911


    REGISTRATION STATEMENT ON FORM S-8
    ----------------------------------


Ladies and Gentlemen:

    We have examined the Registration Statement on Form S-8 (the 
"REGISTRATION STATEMENT") to be filed by Metra Biosystems, Inc. ("METRA") 
with the Securities and Exchange Commission (the "COMMISSION") on or about 
December 17, 1997 in connection with the registration under the Securities Act 
of 1933, as amended, of a total of 800,000 additional shares of Metra Common 
Stock reserved for issuance or issued under Metra's 1995 Stock Option Plan 
("METRA PLAN").  As Metra's legal counsel in connection with this 
transaction, we have examined the proceedings taken and are familiar with the 
proceedings proposed to be taken by Metra in connection with the sale and 
issuance of the foregoing shares under the Metra Plan (collectively, the 
"SHARES").

    It is our opinion that upon conclusion of the proceedings being taken or 
contemplated by us, as Metra's counsel, to be taken prior to the issuance of 
the Shares, and upon completion of the proceedings being taken in order to 
permit such transactions to be carried out in accordance with the securities 
laws of the various states where required, the Shares when issued and sold in 
the manner described in the Registration Statement will be legally and 
validly issued, fully paid and non-assessable.

    We consent to the use of this opinion as an exhibit to the Registration 
Statement and further consent to the use of our name wherever appearing in 
the Registration Statement, including the Prospectus constituting a part 
thereof, and in any amendment thereto.

                                       Very truly yours,

                                       VENTURE LAW GROUP
                                       A Professional Corporation


                                       /s/ VENTURE LAW GROUP


<PAGE>

                                                                  EXHIBIT 23.2


              CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS


    We consent to the incorporation by reference in the Registration 
Statement (Form S-8) pertaining to the 1995 Stock Option Plan of Metra 
Biosystems, Inc. of our report dated July 16, 1997 with respect to the 
consolidated financial statements and schedule of Metra Biosystems, Inc. for 
the year ended June 30, 1997 included in its Annual Report (Form 10-K), filed 
with the Securities and Exchange Commission. 


                                                             ERNST & YOUNG LLP

Palo Alto, California
December 9, 1997


<PAGE>

                                                                  EXHIBIT 23.3


          CONSENT OF KPMG PEAT MARWICK LLP, INDEPENDENT AUDITORS

    We consent to the incorporation by reference in the Registration 
Statement on Form S-8 of our report dated July 18, 1996, with respect to the 
consolidated balance sheet of Metra Biosystems, Inc. and subsidiaries as of 
June 30, 1996 and the related consolidated statements of operations, 
shareholders' equity and cash flows for each of the years in the two-year 
period ended June 30, 1996, which report appears in the June 30, 1997 annual 
report on Form 10-K of Metra Biosystems, Inc. 

                                                         KPMG Peat Marwick LLP 

San Francisco, California
December 15, 1997



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