METRA BIOSYSTEMS INC
SC 13D, 1998-04-24
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                         SCHEDULE 13D

NAME OF ISSUER:  METRA BIOSYSTEMS

TITLE OF CLASS OF SECURITIES:  COMMON STOCK

CUSIP NUMBER:    59114210

NAME, ADDRESS AND TELEPHONE NO:  KURT AMUNDSON, 265 NORTH WHISMAN ROAD,
MOUNTAIN VIEW, CA  94043   PH: 415-903-9100

DATE OF EVENT WHICH REQUIRES FILING OF THIS STATEMENT:  3/24/98

1.  NAME OF REPORTING PERSONS:  IRS: ID NOS. OF ABOVE PERSON:

     THOMAS MITCHELL MANAGEMENT CO. INC. - 13-3589733

2.  CHECK BOX IF A MEMBER OF A GROUP    (B) x

3.  SEC use only

4.  Source of Funds     00

5.   Check if Disclosure of Legal Proceedings is Require Pursuant to Items
  2(d) or 2 (e) not sure - no proceedings.

6.   Citizenship or Place of Organization - State of Delaware

7.   Sole Voting Power -

8.   Shared Voting Power - Thomas Mitchell Mgt. Co. Inc. - 76,800

9.   Sole Dispositive Power - Thomas Mitchell Mgt. Co. Inc.- 76,800

10.  Shared Dispositive Power

11.  Aggregate Amount Beneficially Owned by Each Reporting Person  76,800

12.  Check if the Aggregate Amount in Row (11) Excludes Certain Shares

13.  Percent of Class Represented by Amount in Row (11)  0.61%

14.  Type of Reporting Person
  Thomas Mitchell Management Co. Inc. - IA
 
CUSIP NO: 59114210
SCHEDULE 13D

ITEM #1-  METRA BIOSYSTEMS

ITEM #2-a-   Thomas Mitchell Management Co, Inc.
           b-   POB 31
              Lake Placid, NY  12946
        C-   Investment Advisor
        D-   During the last five years, Thomas Mitchell Management Co., Inc.
has
            not been convicted in a criminal proceeding .
        E-   During the last five years, Thomas Mitchell Management Co., Inc.
was
            not a party to a civil proceeding of a judicial or administrative
body of
            competent jurisdiction and as a result of such proceeding was or is
subject
            to a judgment, decree or final order enjoining future violations
of, or
            prohibiting or mandating activities subject to, federal or state
securities
            laws or finding any violation with respect to such laws.

        F-   U.S.A.

ITEM #3-  Cash from Advisory Accounts

ITEM #4-   For Investment Purposes only.

ITEM #5a-  76,800/ 12,650,000 = 0.61%
       b-Thomas Mitchell Management Co., Inc. shared dispositive power and
       shared voting power
         c- 16,000 -shares purchased to settle 3/24/98 through NASDAQ and
in
            negotiated transactions at prices from $2.25-$2.30 per share.
         d-not applicable
            e-not applicable

ITEM #6- not applicable
ITEM #7-not applicable
 
 
  After reasonable inquiry and to the best of my knowledge and belief, I
  certify that the information set forth in this statement is true,
  complete and correct.
 
  Date: April 3, 1998
 
  Signature:  Thomas S. Mitchell



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