METRA BIOSYSTEMS INC
SC 13D/A, 1998-12-07
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                         SCHEDULE 13D/A

NAME OF ISSUER:  METRA BIOSYSTEMS

TITLE OF CLASS OF SECURITIES:  COMMON STOCK

CUSIP NUMBER:    59114210

NAME, ADDRESS AND TELEPHONE NO:  GEORGE W. DUNBAR, JR., 265 NORTH WHISMAN
ROAD, MOUNTAIN VIEW, CA  94043   PH: 415-903-9100

DATE OF EVENT WHICH REQUIRES FILING OF THIS STATEMENT:  11/30/98

1.  NAME OF REPORTING PERSONS:  IRS: ID NOS. OF ABOVE PERSON:

    THOMAS S.  MITCHELL

2.  CHECK BOX IF A MEMBER OF A GROUP    (B) x

3.  SEC use only

4.  Source of Funds     PF

5.   Check if Disclosure of Legal Proceedings is Require Pursuant to Items
  2(d) or 2 (e) not sure - no proceedings.

6.   Citizenship or Place of Organization - Thomas S. Mitchell-U.S. Citizen

7.   Sole Voting Power - Thomas S. Mitchell- 264,800

8.   Shared Voting Power -

9.   Sole Dispositive Power - Thomas S. Mitchell - 264,800

10.  Shared Dispositive Power

11.  Aggregate Amount Beneficially Owned by Each Reporting Person   264,800

12.  Check if the Aggregate Amount in Row (11) Excludes Certain Shares

13.  Percent of Class Represented by Amount in Row (11)  2.09%

14.  Type of Reporting Person
  Thomas S. Mitchell - IN


CUSIP NO: 59114210
SCHEDULE 13D

ITEM #1-  METRA BIOSYSTEMS

ITEM #2-a-   THOMAS S. MITCHELL
           b-  101 Victor Herbert Road
              POB 31
              Lake Placid, NY  12946
        C-   Investment Advisor
        D-   During the last five years, Thomas S. Mitchell has not been 
             convicted in a criminal proceeding .
        E-   During the last five years, Thomas S. Mitchell was not a party to a
            civil proceeding of a judicial or administrative body of competent
            jurisdiction and as a result of such proceeding was or is subject
            to a judgment, decree or final order enjoining future violations
            of, or prohibiting or mandating activities subject to, federal or
            state securities laws or finding any violation with respect to 
            such laws.

        F-   U.S.A.

ITEM #3-  Cash in personal accounts

ITEM #4-   For Investment Purposes only.

ITEM #5a-  264,800 / 12,689,844 = 2.09%
         b-Thomas S. Mitchell-sole dispositive power and sole voting power
         c- 24,800-shares purchased between 6/30/98 and 11/30/98 through
             NASDAQ and in negotiated transactions at prices from $0.875-
     $2.00 per
             share.
         d-not applicable
            e-not applicable

ITEM #6- not applicable
ITEM #7-not applicable
  
       After reasonable inquiry and to the best of my knowledge and
  belief, I certify that the information set forth in this statement is
  true, complete and correct.
  
  Date:  December 02, 1998
  
  Signature:  Thomas S. Mitchell



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