METRA BIOSYSTEMS INC
SC 13D/A, 1999-01-06
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                         SCHEDULE 13D/A

NAME OF ISSUER:  METRA BIOSYSTEMS

TITLE OF CLASS OF SECURITIES:  COMMON STOCK

CUSIP NUMBER:    59114210

NAME, ADDRESS AND TELEPHONE NO: GEORGE DUNBAR, JR.,  265 NORTH WHISMAN
ROAD, MOUNTAIN VIEW, CA  94043   PH: 415-903-9100

DATE OF EVENT WHICH REQUIRES FILING OF THIS STATEMENT:  12/31/98

1.  NAME OF REPORTING PERSONS:  IRS: ID NOS. OF ABOVE PERSON:

     MITCHELL & HENRY, INC. - 13-3627401

2.  CHECK BOX IF A MEMBER OF A GROUP    (B) x

3.  SEC use only

4.  Source of Funds     00

5.   Check if Disclosure of Legal Proceedings is Require Pursuant to Items
  2(d) or 2 (e) not sure - no proceedings.

6.   Citizenship or Place of Organization - State of New York

7.   Sole Voting Power -

8.   Shared Voting Power -Mitchell & Henry, Inc.- 462,100

9.   Sole Dispositive Power - Mitchell & Henry, Inc. -462,100

10.  Shared Dispositive Power

11.  Aggregate Amount Beneficially Owned by Each Reporting Person 462,100

12.  Check if the Aggregate Amount in Row (11) Excludes Certain Shares

13.  Percent of Class Represented by Amount in Row (11)  3.64%

14.  Type of Reporting Person
  
     MITCHELL & HENRY, INC.-IA
  
CUSIP NO: 59114210
SCHEDULE 13D/A

ITEM #1-  METRA BIOSYSTEMS

ITEM #2-a-   Mitchell & Henry, Inc.-Robert A. Henry, President; Thomas S.
Mitchell,
             Chief Investment Officer
           b-   POB 31
              Lake Placid, NY  12946
        C-   Investment Advisor
        D-   During the last five years, Mitchell & Henry, Inc.,  Thomas S.
            Mitchell and/or Robert A. Henry, have not been convicted in a 
            criminal proceeding .
        E-   During the last five years, Mitchell & Henry, Inc., Thomas S.
            Mitchell and/or Robert A. Henry, have not a party to a civil
            proceeding of a judicial or administrative body of competent
            jurisdiction and as a result of such proceeding was or is subject
            to a judgment, decree or final order enjoining future violations
            of, or prohibiting or mandating activities subject to, federal or
            state securities laws or finding any violation with respect to
            such laws.

        F-   U.S.A.

ITEM #3-  Cash from Advisory Accounts

ITEM #4-   For Investment Purposes only.

ITEM #5a-  462,100/ 12,689,844 = 3.64%
       b- Thomas S. Mitchell and Robert A. Henry shared dispositive power
       and shared voting power
          c- 555,800 shares recently sold  in various lots through NASDAQ
and in
             negotiated transactions at  prices from $.8750 -$2.00 per
share.
          d-not applicable
             e-not applicable

ITEM #6- not applicable
ITEM #7-not applicable
  
  
  After reasonable inquiry and to the best of my knowledge and belief, I
  certify that the information set forth in this statement is true,
  complete and correct.
  
  Date:  January 5, 1999
  
  Signature:  Thomas S. Mitchell
  
  Title:  Chief Investment Officer



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