INVESTMENT SERIES FUNDS INC
24F-2NT, 2000-01-28
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3


                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   FORM 24F-2
                        Annual Notice of Securities Sold
                             Pursuant to Rule 24f-2

                              Read             instructions at end of Form
                                               before preparing Form. Please
                                               print or type.

1.       Name and address of issuer:
                          Investment Series Funds, Inc.
                               Federated Investors
                            Federated Investors Tower
                       Pittsburgh, Pennsylvania 15222-3779
2.       The name of each series or class of securities for which this Form is
         filed (If the Form is being filed for all series and classes of
         securities of the issuer, check the box but do not list series or
         classes):
          [ X ]






3.       Investment Company Act File Number:           811-07021


         Securities Act File Number:                   33-48847





4(a). Last day of fiscal year for which this Form is filed: October 31, 1999



4(b).[ ] Check  box if  this  Form is  being  filed  late  (i.e.,  more  than 90
     calendar days after the end of the issuer's fiscal year).  (See Instruction
     A.2)

Note:If the Form is being filed late,  interest must be paid on the registration
     fee due.




4(c). [ ] Check box if this is the last time the issuer will be filing this
Form.




<PAGE>


5. Calculation of registration fee:

         (i)      Aggregate sale price of securities sold during
                  the fiscal year pursuant to section 24(f):        $455,974,367
                                                                     -----------

         (ii)     Aggregate price of securities redeemed or
                  repurchased during the fiscal year:         $288,098,663

         (iii)    Aggregate price of securities redeemed or repurchased during
                  any prior fiscal year ending no earlier than October 11, 1995
                  that were not previously used to reduce registration
                  fees payable to the Commission:                        $  0
                                                                          ---

         (iv)     Total available redemption credits [add Items 5(ii)
                  and 5(iii)]:                                    --$167,875,704

         (v) Net sales -- if Item 5(i) is greater than Item 5(iv)
                  [subtract Item 5(iv) from Item 5(i)]:            $167,875,704
                                                                   -----------

         (vi)     Redemption credits available for use in future years
                  -- if Item 5(i) is less than Item 5(iv) [subtract
                  Item 5(iv) from Item 5(i)]:                         $(0)
                                                                       ---

         (vii)    Multiplier for determining registration fee
                  (See Instruction C.9):                           x    0.000264

         (viii) Registration fee due [multiply Item 5(v) by Item
                  5(vii)] (enter "0" if no fee is due):                 =$44,319
                                                                          ------

6.       Prepaid Shares

         If the response to item 5(i) was determined by deducting an amount of
         securities that were registered under the Securities Act of 1933
         pursuant to rule 24e-2 as in effect before [effective date of
         rescisison of rule 24e-2], then report the amount of securities (number
         of shares or other units) deducted here: -0-. If there is a number of
         shares or other units that were registered pursuant to rule 24e-2
         remaining unsold at the end of the fiscal year for which this form is
         filed that are available for use by the issuer in future fiscal years,
         then state that number here: -0-.
7.       Interest due -- if this Form is being filed more than 90 days after the
         end of the issuer's fiscal year (see Instruction D):
         +$------------
8.       Total of the amount of the registration fee due plus any interest due
         [line 5(viii) plus line 7]:                                   =$
                                                                        -
         44,319
         ------

9.   Date the registration fee and any interest payment was sent to the
     Commission's lockbox depository: January 26, 2000
        Method of Delivery:
                  [ X ]     Wire Transfer
                  [   ]    Mail or other means



<PAGE>



                                                    SIGNATURES


This              Form has been signed below by the following persons on behalf
                  of the issuer and in the capacities and on the dates
                  indicated.


By (Signature and Title)*  /s/Deborah M. Molini


                           Deborah M. Molini, Assistant Treasurer


Date:


*    Please print the name and title of the signing officer below the signature.



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