NPS PHARMACEUTICALS INC
SC 13G, 2000-02-11
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                   Under the Securities Exchange Act of 1934

                       (Amendment No.                )*
                                      ---------------
                           NPS PHARMACEUTICALS, INC.
- --------------------------------------------------------------------------------
                               (Name of Issuer)

                                 Common Stock
- --------------------------------------------------------------------------------
                        (Title of Class of Securities)

                                   62936P103
- --------------------------------------------------------------------------------
                                (CUSIP Number)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).



Schedule is filed pursuant to Rule 13d-1(b).


                               Page 1 of 6 pages
<PAGE>
- -------------------                                            -----------------
CUSIP No. 62936P103                   13G                      Page 2 of 6 Pages
- -------------------                                            -----------------
- --------------------------------------------------------------------------------
      NAME OF REPORTING PERSON
 1    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

      Wanger Asset Management, L.P. 36-3820584

- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [_]
      Not Applicable                                            (b) [_]

- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
      Delaware

- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF            None

      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
                          640,300
     OWNED BY
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING             None

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          640,300
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      640,300
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10
                                                                    [_]
      Not Applicable
- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11
      5.0%

- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON*
12
      IA

- ------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- -------------------                                            -----------------
CUSIP No. 62936P103                  13G                       Page 3 of 6 Pages
- -------------------                                            -----------------
- --------------------------------------------------------------------------------
      NAME OF REPORTING PERSON
 1    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

      Wanger Asset Management, Ltd.

- --------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [_]
      Not Applicable                                            (b) [_]

- --------------------------------------------------------------------------------
      SEC USE ONLY
 3


- --------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
      Delaware

- --------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF            None

      SHARES       -------------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
                          640,300
     OWNED BY
                   -------------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING             None

      PERSON       -------------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          640,300
- --------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      640,300
- --------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10
                                                                    [_]
      Not Applicable
- --------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11
      5.0%

- --------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON*
12
      CO

- --------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>

Item 1(a) Name of Issuer:

               NPS Pharmaceuticals, Inc.

Item 1(b) Address of Issuer's Principal Executive Offices:

               420 Chipeta Way
               Salt Lake City, Utah  84108

Item 2(a) Name of Person Filing:

               Wanger Asset Management, L.P. ("WAM")
               Wanger Asset Management Ltd., the general partner of WAM
               ("WAM LTD.")

Item 2(b) Address of Principal Business Office:

               WAM and WAM LTD. are both located at:
               227 West Monroe Street, Suite 3000
               Chicago, Illinois  60606

Item 2(c) Citizenship:

               WAM is a Delaware limited partnership; and WAM LTD. is a
               Delaware corporation.

Item 2(d) Title of Class of Securities:

               Common Stock

Item 2(e) CUSIP Number:

               62936P103

Item 3    Type of Person:
               (e)  WAM is an Investment Adviser registered under section 203 of
                    the Investment Advisers Act of 1940; WAM LTD. is the General
                    Partner of the Investment Adviser.

Item 4    Ownership (at December 31, 1999):

               (a)  Amount owned "beneficially" within the meaning of rule
                    13d-3:

                    640,300

                               Page 4 of 6 Pages
<PAGE>

               (b)  Percent of class:

                         5.0%

               (c)  Number of shares as to which such person has:

                         (i)    sole power to vote or to direct the vote:
                                none
                         (ii)   shared power to vote or to direct the vote:
                                640,300
                         (iii)  sole power to dispose or to direct the
                                disposition of:  none
                         (iv)   shared power to dispose or to direct
                                disposition of:  640,300

Item 5    Ownership of Five Percent or Less of a Class:

               Not Applicable

Item 6    Ownership of More than Five Percent on Behalf of Another Person:

               The shares reported herein have been acquired on behalf of
               discretionary clients of WAM.  Persons other than WAM and
               WAM LTD. are entitled to receive all dividends from, and
               proceeds from the sale of, those shares.

Item 7    Identification and Classification of the Subsidiary Which Acquired the
          Security Being Reported on by the Parent Holding Company:

               Not Applicable

Item 8    Identification and Classification of Members of the Group:

               Not Applicable

Item 9    Notice of Dissolution of Group:

               Not Applicable

Item 10   Certification:

               By signing below I certify that, to the best of my knowledge and
          belief, the securities referred to above were acquired and are held in
          the ordinary course of business and were not acquired and are not held
          for the purpose of or with the effect of changing or influencing the
          control of the issuer of the securities and were not acquired and are
          not held in connection with or as a participant in any transaction
          having that purpose or effect.


                               Page 5 of 6 Pages
<PAGE>

                                   Signature
                                   ---------

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Date:  February 11, 2000

               The undersigned corporation, on the date above written, agrees
               and consents to the joint filing on its behalf of this Schedule
               13G in connection with its beneficial ownership of the security
               reported herein.

                              WANGER ASSET MANAGEMENT, LTD.
                              for itself and as general partner of
                              WANGER ASSET MANAGEMENT, L.P.


                              By:  /s/ Bruce H. Lauer
                                   ------------------
                                       Bruce H. Lauer
                                       Vice President


                               Page 6 of 6 Pages


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