VAN KAMPEN SERIES FUND INC
497, 2000-06-05
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<PAGE>   1

                          VAN KAMPEN SERIES FUND, INC.
                            ON BEHALF OF ITS SERIES
                         VAN KAMPEN EQUITY GROWTH FUND

                      SUPPLEMENT DATED JUNE 5, 2000 TO THE
                       PROSPECTUS DATED OCTOBER 28, 1999,
                       SUPERCEDING ALL PRIOR SUPPLEMENTS

    The Prospectus is hereby supplemented as follows:

    (1) The first paragraph in the section entitled "INVESTMENT ADVISORY
SERVICES -- INVESTMENT ADVISER -- ADVISORY AGREEMENT AND ADMINISTRATION
AGREEMENT" is hereby deleted and replaced in its entirety with the following:

    The Fund retains the Adviser to manage the investment of its assets and to
place orders for the purchase and sale of its portfolio securities. Under an
investment advisory agreement between the Adviser and the Fund (the "Advisory
Agreement"), the Fund pays the Adviser a monthly fee computed based upon an
annual rate applied to the average daily net assets of the Fund as follows:

<TABLE>
<CAPTION>
AVERAGE DAILY NET ASSETS                            % PER ANNUM
------------------------                           -------------
<S>                                                <C>
First $500 million...............................  0.80 of 1.00%
Next $500 million................................  0.75 of 1.00%
Over $1 billion..................................  0.70 of 1.00%
</TABLE>

    (2) The section entitled "INVESTMENT ADVISORY
SERVICES -- GENERAL -- PORTFOLIO MANAGEMENT" is hereby deleted in its entirety
and replaced with the following:

    PORTFOLIO MANAGEMENT. The Fund's portfolio managers are Philip W.
Friedman and William S. Auslander.

    Mr. Friedman is a Managing Director of the Subadviser and of Morgan Stanley
& Co. Incorporated and leads its Institutional Equity Group. Prior to joining
the Subadviser in 1997, Mr. Friedman was the North American Director of Equity
Research at Morgan Stanley & Co. Incorporated. From 1990 to 1995, he was a
member of Morgan Stanley & Co. Incorporated's Equity Research team. Mr. Friedman
graduated from Rutgers University with a B.A. (Phi Beta Kappa; Summa Cum Laude)
in Economics. He also holds an M.B.A. from J.L. Kellogg School of Management at
Northwestern University.

    Mr. Auslander is a Principal of the Subadviser and Morgan Stanley & Co.
Incorporated and a Portfolio Manager in the Institutional Equity Group. He
joined the Subadviser in 1995 as an equity analyst in the International Equity
Group. Prior to joining the Subadviser, Mr. Auslander was an equity analyst at
Icahn & Co. for
<PAGE>   2

nine years. He graduated from the University of Wisconsin at Madison with a B.A.
in Economics and received an M.B.A. from Columbia University in 1993.

    (3) The information on the inside back cover of the Prospectus under the
heading "BOARD OF DIRECTORS AND OFFICERS -- BOARD OF DIRECTORS" is hereby
amended by deleting Paul G. Yovovich, effective April 14, 2000, and by deleting
and replacing Richard M. DeMartini* and Don G. Powell* with Mitchell M. Merin*
and Richard F. Powers, III*, effective December 15, 1999.

    (4) The information on the inside back cover of the Prospectus under the
heading "BOARD OF DIRECTORS AND OFFICERS -- OFFICERS" is hereby amended by
deleting all information pertaining to Curtis W. Morell* and Tanya M. Loden*,
effective January 31, 2000, Dennis J. McDonnell*, effective March 31, 2000,
Peter W. Hegel*, effective May 31, 2000, and by deleting and replacing Stephen
L. Boyd's title of Vice President with Executive Vice President and Chief
Investment Officer and Edward C. Wood, III*, Vice President, with John H.
Zimmermann, III*, Vice President, effective April 17, 2000.

    (5) The information on the inside back cover of the Prospectus under the
heading "FOR MORE INFORMATION -- INDEPENDENT ACCOUNTANTS" is hereby deleted and
replaced with the following:

                           DELOITTE & TOUCHE LLP
                           Two Prudential Plaza
                           180 N. Stetson Avenue
                           Chicago, Illinois 60601

                  RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE


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