VAN KAMPEN SERIES FUND INC
497, 2000-01-31
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                                   VAN KAMPEN
                            GLOBAL FIXED INCOME FUND

                                A SERIES OF THE
                          VAN KAMPEN SERIES FUND, INC.

                       SUPPLEMENT DATED JANUARY 31, 2000
                   TO THE PROSPECTUS DATED OCTOBER 28, 1999,
               SUPERCEDING THE SUPPLEMENT DATED JANUARY 11, 2000

     (1) The Prospectus is supplemented with the following:

          The Board of Trustees has continuously reviewed the investment
     policies and practices, performance, expenses and reduced net assets of the
     Van Kampen Global Fixed Income Fund (the "Fund"). In connection therewith,
     the Board considered various alternatives including a possible merger or
     liquidation of the Fund. After due consideration of a number of factors,
     including those listed above, the Board determined that it would be in the
     best interest of the shareholders to terminate and liquidate the Fund. On
     January 27, 2000, the Board approved a Plan of Liquidation for the Fund.
     The Plan of Liquidation will be presented to the shareholders of the Fund
     for approval. As a result of the Board's approval, the Fund is suspending
     the continuous offering of its shares to new investors of the Fund
     effective at the close of business February 2, 2000. Currently, existing
     shareholders of the Fund as of February 2, 2000 may continue to purchase
     shares of the Fund. Dividends subject to automatic reinvestment in the Fund
     according to previous instructions of existing shareholders will continue
     to be reinvested in shares of the Fund.

     (2) The section of the inside back cover of the Prospectus entitled BOARD
     OF DIRECTORS AND OFFICERS -- BOARD OF DIRECTORS is hereby supplemented by
     deleting Richard M. DeMartini* and Don G. Powell* and adding Mitchell M.
     Merin* and Richard F. Powers, III*, effective December 15, 1999.

     * "Interested Persons" of the Fund, as defined in the Investment Company
     Act of 1940, as amended.


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