<TABLE> <S> <C>
<ARTICLE> 6
<CIK> 0000891080
<NAME> VAN KAMPEN SERIES FUND, INC.
<SERIES>
<NUMBER> 153
<NAME> VAN KAMPEN VALUE FUND (CLASS C)
<MULTIPLIER> 1
<S> <C>
<PERIOD-TYPE> 12-MOS
<FISCAL-YEAR-END> JUN-30-2000
<PERIOD-START> JUL-01-1999
<PERIOD-END> JUN-30-2000
<INVESTMENTS-AT-COST> 141,672,535
<INVESTMENTS-AT-VALUE> 138,384,852
<RECEIVABLES> 235,052
<ASSETS-OTHER> 4,999
<OTHER-ITEMS-ASSETS> 3,154
<TOTAL-ASSETS> 138,628,057
<PAYABLE-FOR-SECURITIES> 0
<SENIOR-LONG-TERM-DEBT> 0
<OTHER-ITEMS-LIABILITIES> 1,078,965
<TOTAL-LIABILITIES> 1,078,965
<SENIOR-EQUITY> 0
<PAID-IN-CAPITAL-COMMON> 170,967,510
<SHARES-COMMON-STOCK> 1,625,121
<SHARES-COMMON-PRIOR> 8,747,187
<ACCUMULATED-NII-CURRENT> 4,600
<OVERDISTRIBUTION-NII> 0
<ACCUMULATED-NET-GAINS> 0
<OVERDISTRIBUTION-GAINS> (30,135,335)
<ACCUM-APPREC-OR-DEPREC> (3,287,683)
<NET-ASSETS> 137,549,092
<DIVIDEND-INCOME> 3,371,536
<INTEREST-INCOME> 171,875
<OTHER-INCOME> 0
<EXPENSES-NET> (3,519,133)
<NET-INVESTMENT-INCOME> 24,278
<REALIZED-GAINS-CURRENT> (20,783,017)
<APPREC-INCREASE-CURRENT> (20,622,025)
<NET-CHANGE-FROM-OPS> (41,380,764)
<EQUALIZATION> 0
<DISTRIBUTIONS-OF-INCOME> 0
<DISTRIBUTIONS-OF-GAINS> 0
<DISTRIBUTIONS-OTHER> 0
<NUMBER-OF-SHARES-SOLD> 382,726
<NUMBER-OF-SHARES-REDEEMED> (1,441,518)
<SHARES-REINVESTED> 0
<NET-CHANGE-IN-ASSETS> (114,707,925)
<ACCUMULATED-NII-PRIOR> 0
<ACCUMULATED-GAINS-PRIOR> (9,310,713)
<OVERDISTRIB-NII-PRIOR> (1,192)
<OVERDIST-NET-GAINS-PRIOR> 0
<GROSS-ADVISORY-FEES> 1,462,823
<INTEREST-EXPENSE> 0
<GROSS-EXPENSE> 3,646,698
<AVERAGE-NET-ASSETS> 182,815,885
<PER-SHARE-NAV-BEGIN> 10.83
<PER-SHARE-NII> (0.03)
<PER-SHARE-GAIN-APPREC> (1.83)
<PER-SHARE-DIVIDEND> 0
<PER-SHARE-DISTRIBUTIONS> 0
<RETURNS-OF-CAPITAL> 0
<PER-SHARE-NAV-END> 8.97
<EXPENSE-RATIO> 2.20
</TABLE>
