CELL THERAPEUTICS INC
4, 2000-10-10
PHARMACEUTICAL PREPARATIONS
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                     U.S. SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549

                                     FORM 4

                  STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

|_|   Check this box if no longer subject to Section 16. Form 4 or Form 5
      obligations may continue. See Instruction 1(b).

================================================================================
1. Name and Address of Reporting Person*

   Rosenwald, M.D., Lindsay A.
--------------------------------------------------------------------------------
   (Last)               (First)                 (Middle)

   c/o Paramount Capital Asset Management, Inc., 787 Seventh Avenue, 48th Floor
--------------------------------------------------------------------------------
                                    (Street)

   New York               NY                    10019
--------------------------------------------------------------------------------
   (City)               (State)                 (Zip)

================================================================================
2. Issuer Name and Ticker or Trading Symbol

   Cell Therapeutics, Inc. (CTIC)
================================================================================
3. IRS Identification Number of Reporting Person, if an Entity (Voluntary)


================================================================================
4. Statement for Month/Year

   September 2000
================================================================================
5. If Amendment, Date of Original (Month/Year)


================================================================================
6. Relationship of Reporting Person to Issuer
   (Check all applicable)

   |_|   Director                             |X|   10% Owner
   |_|   Officer (give title below)           |_|   Other (specify below)

================================================================================
7. Individual or Joint/Group Filing (Check Applicable Line)

   |_|  Form filed by one Reporting Person
   |X|  Form filed by more than one Reporting Person

================================================================================

* If the Form is filed by more than one Reporting Person, see Instruction
  4(b)(v).
<PAGE>

================================================================================
           Table I -- Non-Derivative Securities Acquired, Disposed of,
                             or Beneficially Owned
================================================================================
<TABLE>
<CAPTION>
                                                                                                     6.
                                                      4.                              5.             Owner-
                                                      Securities Acquired (A) or      Amount of      ship
                                         3.           Disposed of (D)                 Securities     Form:     7.
                                         Transaction  (Instr. 3, 4 and 5)             Beneficially   Direct    Nature of
                           2.            Code         ----------------------------    Owned at End   (D) or    Indirect
1.                         Transaction   (Instr. 8)                   (A)             of Month       Indirect  Beneficial
Title of Security          Date          ------------     Amount      or     Price    (Instr. 3      (I)       Ownership
(Instr. 3)                 (mm/dd/yy)     Code     V                  (D)             and 4)         (Instr.4) (Instr. 4)
------------------------------------------------------------------------------------------------------------------------------------
<S>                        <C>            <C>      <C>    <C>         <C>    <C>      <C>            <C>       <C>
Common Stock               09/11/00       P               5,946       A      $41.188  4,973,087(1)   I         By The Aries Master
                                                                                                               Fund II(2)
------------------------------------------------------------------------------------------------------------------------------------
Common Stock               09/11/00       P               3,097       A      $41.188  4,973,087(1)   I         By Aries Domestic
                                                                                                               Fund, L.P.(2)
------------------------------------------------------------------------------------------------------------------------------------
Common Stock               09/11/00       P                 957       A      $41.188  4,973,087(1)   I        By Aries Domestic
                                                                                                              Fund II, L.P.(2)
------------------------------------------------------------------------------------------------------------------------------------
Common Stock               09/29/00       J           1,460,877(3)    A        $.001  4,973,087(1)   D
====================================================================================================================================
</TABLE>

Reminder: Report on a separate line for each class of securities beneficially
owned directly or indirectly.


                                   Page 1 of 3
<PAGE>

FORM 4 (continued)

Table II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned
            (e.g., puts, calls, warrants, options, convertible securities)

================================================================================
<TABLE>
<CAPTION>
                                                                                                          9.        10.
                                                                                                          Number    Owner-
                                                                                                          of        ship
                    2.                                                                                    Deriv-    Form of
                    Conver-                    5.                              7.                         ative     Deriv-   11.
                    sion                       Number of                       Title and Amount           Secur-    ative    Nature
                    of                         Derivative    6.                of Underlying     8.       ities     Secur-   of
                    Exer-             4.       Securities    Date              Securities        Price    Bene-     ity:     In-
                    cise     3.       Trans-   Acquired (A)  Exercisable and   (Instr. 3 and 4)  of       ficially  Direct   direct
                    Price    Trans-   action   or Disposed   Expiration Date   ----------------  Deriv-   Owned     (D) or   Bene-
1.                  of       action   Code     of(D)         (Month/Day/Year)            Amount  ative    at End    In-      ficial
Title of            Deriv-   Date     (Instr.  (Instr. 3,    ----------------            or      Secur-   of        direct   Owner-
Derivative          ative    (Month/  8)       4 and 5)      Date     Expira-            Number  ity      Month     (I)      ship
Security            Secur-   Day/     ------   ------------  Exer-    tion               of      (Instr.  (Instr.   (Instr.  (Instr.
(Instr. 3)          ity      Year)    Code V    (A)   (D)    cisable  Date     Title     Shares  5)       4)        4)       4)
------------------------------------------------------------------------------------------------------------------------------------
<S>                 <C>      <C>      <C>  <C>  <C>   <C>    <C>      <C>      <C>       <C>     <C>      <C>       <C>      <C>
N/A
====================================================================================================================================
</TABLE>
Explanation of Responses:

(1)   See Attachment A.

(2)   Paramount Capital Asset Management, Inc. ("PCAM") is the general partner
      of each of the Aries Domestic Fund, L.P. ("Aries I") and Aries Domestic
      Fund II, L.P. ("Aries II"), each a Delaware limited partnership, and also
      serves as the investment manager of the Aries Master Fund II, a Cayman
      Island exempted company (the "Master Fund"), which also owns securities of
      the Issuer. Dr. Rosenwald is the chairman and sole stockholder of PCAM. As
      a result, Dr. Rosenwald and PCAM may be deemed to have voting and
      investment control over the securities of the issuer owned by the Aries
      Funds under Rule 16a-(a)(1) of the Securities Exchange Act of 1934. Dr.
      Rosenwald and PCAM disclaim beneficial ownership of the securities held by
      the Aries Funds, except to the extent of its pecuniary interest therein,
      if any.

(3)   Dr. Rosenwald acquired these shares as a milestone payment by the Company
      to the former shareholders of PolaRx Biopharmaceuticals, Inc. Shareholder
      approval for this issuance was obtained on September 29, 2000. Details
      regarding the foregoing are described in the Definitive Proxy Statement
      filed by the Company on September 11, 2000.

**  Intentional misstatements or omissions of facts constitute Federal Criminal
    Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).


/s/ Lindsay A. Rosenwald, M.D.                               October 6, 2000
---------------------------------------------            -----------------------
** Signature of Reporting Person                                  Date
   Lindsay A. Rosenwald, M.D.

Note: File three copies of this Form, one of which must be manually signed. If
      space provided is insufficient, see Instruction 6 for procedure.


                                   Page 2 of 3
<PAGE>

                                  Attachment A

Securities beneficially owned by Dr. Rosenwald are presented on an as-converted
basis and consist of the following:

1.    2,434,795 shares of Common Stock owned directly by Dr. Rosenwald;

2.    780,578 shares of Common Stock issuable upon conversion of 1,688 shares of
      Series C Convertible Preferred Stock; Warrants to purchase 257,219 shares
      of Common Stock; and 644,264 shares of Common Stock purchased in the open
      market owned the Aries Master Fund II;

3.    316,301 shares of Common Stock issuable upon conversion of 684 shares of
      Series C Convertible Preferred Stock; Warrants to purchase 104,229 shares
      of Common Stock; and 332,229 shares of Common Stock purchased in the open
      market owned Aries Domestic Fund, L.P.; and

4.    24,509 shares of Common Stock issuable upon conversion of 53 shares of
      Series C Convertible Preferred Stock; Warrants to purchase 8,076 shares of
      Common Stock; and 70,887 shares of Common Stock purchased in the open
      market owned Aries Domestic Fund II, L.P.


                                   Page 3 of 3



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