NAPRO BIOTHERAPEUTICS INC
DEF 14A, 1996-07-12
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                                  SCHEDULE 14A
                                 (Rule 14a-101)

                    INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION
                   Proxy Statement Pursuant to Section 14(a)
                     of the Securities Exchange Act of 1934

Filed by the registrant  [X]
Filed by a party other than the registrant  [ ]

Check the appropriate box:

[ ] Preliminary proxy statement
[X] Definitive proxy statement
[ ] Definitive additional materials
[ ] Soliciting material pursuant to Rule 14a-11(c) or Rule 14a-12

                          NAPRO BIOTHERAPEUTICS, INC.
                ------------------------------------------------
                (Name of Registrant as Specified in Its Charter)
                          NaPro BioTherapeutics, Inc.
                  -------------------------------------------
                  (Name of Persons(s) Filing Proxy Statement)

Payment of filing fee (Check the appropriate box):

[ ] $125 per Exchange Act Rule 0-11(c)(1)(ii), 14a-6(i)(1), or 14a-6(j)(2).

[ ] $500 per each party to the controversy pursuant to Exchange Act 
    Rule 14a-6(i)(3).

[ ] Fee computed on the table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

    (1) Title of each class of securities to which transaction applies:

    (2) Aggregate number of securities to which transactions apply:

    (3) Per unit price or other underlying value of transaction computed 
        pursuant to Exchange Act Rule 0 -11:

    (4) Proposed maximum aggregate value of transaction:

[X] Check box if any part of the fee is offset as provided by Exchange Act 
    Rule 0-11(a)(2) and identify the filing for which the offsetting fee was 
    paid previously. Identify the previous filing by registration statement 
    number, or the form or schedule and the date of its filing.

    (1) Amount previously paid: $125

    (2) Form, schedule or registration statement no.: Schedule 14A

    (3) Filing party: NaPro Biotherapeutics, Inc.

    (4) Date filed: June 6, 1996


<PAGE>

                           NAPRO BIOTHERAPEUTICS, INC.
                             6304 Spine Road, Unit A
                             Boulder, Colorado 80301
                       -----------------------------------

                    Notice of Annual Meeting of Stockholders
                           to be held on July 30, 1996
                       -----------------------------------

TO THE STOCKHOLDERS OF NAPRO BIOTHERAPEUTICS, INC.

         NOTICE IS HEREBY GIVEN that the Annual Meeting of Stockholders of NaPro
BioTherapeutics, Inc. (the "Company"), a Delaware corporation, will be held on
July 30, 1996, at 9:00 A.M. at the Conference Center at the Raintree Plaza
Hotel, 1850 Industrial Circle, Longmont, Colorado, for the following purposes:

         1.       In connection with proposal 2, to elect three Class I 
directors to serve until the next annual meeting of stockholders, three Class II
directors to serve until the 1998 annual meeting of stockholders and three Class
III directors to serve until the 1999 annual meeting of stockholders, or if
proposal 2 is not approved, to elect nine directors to serve until the next
annual meeting of stockholders;

         2.       To approve amendments to the Company's Amended and Restated
Certificate of Incorporation to (a) classify the Board of Directors into three
classes; (b) provide that directors may be removed only for cause and only with
the approval of the holders of at least 80% of the voting power of the Company;
and (c) require the concurrence of the holders of at least 80% of the voting
power of the Company to alter, amend or repeal, or to adopt any provision
inconsistent with, the foregoing amendments;

         3.       To approve amendments to the Company's 1994 Long-Term 
Performance Incentive Plan (the "1994 Plan") to: (i) increase the maximum number
of shares of Common Stock issuable as awards under the Plan from 375,000 to
875,000 (of which 180,000 shares will be reserved for issuance to non-employee
directors under the formula provisions of the 1994 Plan); (ii) provide that the
maximum number of underlying shares of Common Stock that any participant may be
granted under awards under the Plan in any one taxable year will be 200,000
shares; (iii) increase the number of shares of Common Stock underlying automatic
grants of non-qualified stock options to non-employee directors from 5,000 to
10,000 shares; (iv) provide for automatic grants of non-qualified stock options
to purchase 10,000 shares of Common Stock to each director who serves as
chairman of the Audit, Compensation and Strategic Planning Committees of the
Board of Directors; (v) provide for a period of 90 days following termination of
an employee's relationship with the Company, or for a period of three years in
the case of a resignation or removal of a non-employee director, during which
vested stock options granted under the 1994 Plan will remain exercisable, unless
an employee or a non-employee director, as the case may be, is terminated or
removed for cause; and (vi) provide that plan participants who resume employment
or performance of services for the Company after termination by reason of
disability may exercise unvested stock options in accordance with a revised
vesting schedule and that the expiration date of such stock options (other than
incentive stock options) be automatically extended by the length of time such
participant remained terminated by reason of disability.

         4.       To ratify the selection by the Board of Directors of Ernst & 
Young LLP as the Company's independent auditors for the year ending December 31,
1996; and

         5.       To transact such other business as may properly come before
the meeting or any adjournment or postponement of the meeting.

         The Board of Directors has fixed the close of business on May 31, 1996
as the record date for the determination of stockholders entitled to notice of,
and to vote at this Annual Meeting and at any adjournment or postponement
thereof.



<PAGE>
         ALL STOCKHOLDERS ARE CORDIALLY INVITED TO ATTEND THE MEETING.  TO 
ENSURE YOUR REPRESENTATION AT THE MEETING, HOWEVER, YOU ARE ENCOURAGED TO MARK,
SIGN, DATE, AND RETURN THE ENCLOSED PROXY AS PROMPTLY AS POSSIBLE. A POSTAGE
PREPAID ENVELOPE IS ENCLOSED FOR THAT PURPOSE.

         ANY STOCKHOLDER ATTENDING THE MEETING MAY VOTE IN PERSON EVEN IF THAT
STOCKHOLDER HAS RETURNED A PROXY.


                                          By Order of the Board of Directors




                                          Patricia A. Pilia, Ph.D.
                                          Secretary

Boulder, Colorado
July 12, 1996
<PAGE>

                           NAPRO BIOTHERAPEUTICS, INC.
                             6304 Spine Road, Unit A
                             Boulder, Colorado 80301

                                 PROXY STATEMENT

GENERAL

         The enclosed proxy is solicited by the Board of Directors of NaPro
BioTherapeutics, Inc. (the "Company" or "NaPro") for use at the Annual Meeting
of Stockholders to be held on July 30, 1996, at 9:00 A.M. at the Conference
Center at the Raintree Plaza Hotel, 1850 Industrial Circle, Longmont, Colorado,
or at any adjournment or postponement of that meeting, for the purposes set
forth in the foregoing Notice of Annual Meeting. This Proxy Statement is being
furnished to holders of the Company's voting common stock, $0.0075 par value per
share ("Common Stock") and Series A Convertible Preferred Stock, $.001 par value
per share ("Preferred Stock"). The cost of solicitation of proxies will be paid
by the Company. Copies of solicitation material will be furnished to brokers,
fiduciaries, and custodians to forward to beneficial owners of Common Stock
and/or Preferred Stock held in their names. The Company will reimburse brokers
and other persons representing beneficial owners of shares for their expenses in
forwarding solicitation material to such beneficial owners. This Proxy Statement
and accompanying proxy will be mailed on or about July 12, 1996, to all
stockholders entitled to vote at the meeting. Unless the context otherwise
requires, the terms, "Company" and "NaPro" include the Company and each of its
subsidiaries.


ANNUAL REPORT

         The Annual Report to Stockholders covering NaPro's fiscal year ended
December 31, 1995, including audited financial statements is enclosed herewith.
This Annual Report to Stockholders does not form any part of the material for
the solicitation of proxies.


STOCKHOLDER PROPOSALS

         Proposals by stockholders that are intended to be presented at the
Company's 1997 Annual Meeting of Stockholders must be received by the Secretary
of the Company not later than January 1, 1997, in order to be included in the
proxy statement and proxy relating to the 1997 Annual Meeting.


VOTING SECURITIES,  REVOCABILITY OF PROXY

         Only stockholders of record at the close of business on May 31, 1996,
are entitled to notice of and to vote at the meeting. As of May 31, 1996, there
were 8,522,896 shares of Common Stock and 125,000 shares of Preferred Stock
outstanding. Each such share is entitled to one vote. There are no other classes
of voting securities outstanding. Abstentions and broker votes are counted for
purposes of determining the presence or absence of a quorum for the transaction
of business. For proposal 1, directors are elected by a plurality of the votes
cast at the annual meeting. Approval of Proposal 2 to amend the Company's
Amended and Restated Articles of Incorporation requires the affirmative vote of
a majority of the outstanding shares of Common Stock and Preferred Stock as of
the Record Date voting as a single class. Approval of Proposal 3 to amend the
Company's 1994 Long-Term Performance Incentive Plan (the "1994 Plan") and
Proposal 4 to ratify the selection of Ernst & Young LLP as the Company's
independent auditors requires the affirmative vote of a majority of the shares
of Common Stock and Preferred Stock voting as a single class represented in
person or by proxy at the annual meeting and entitled to vote. All votes will be
tabulated by the inspector of election appointed for the meeting, who will
separately tabulate affirmative and negative votes, and broker non-votes. Broker
non-votes are not counted for any purpose in determining whether a matter has
been approved.

<PAGE>

         Any stockholder giving a proxy has the power to revoke it any time
before it is exercised. Proxies may be revoked by filing with the Secretary of
the Company at the principal executive office of the Company, 6304 Spine Road,
Unit A, Boulder, Colorado, 80301, a written notice of revocation, or a duly
executed proxy bearing a later date. Proxies may also be revoked by attendance
at the Annual Meeting and an election to vote in person.

                                        1
<PAGE>



SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

         The following table sets forth certain information as of May 31, 1996,
regarding ownership of the Common Stock and the Preferred Stock by (1) persons
believed by the Company to be the beneficial owners of more than five percent of
its outstanding Common Stock and Preferred Stock; (2) by each Director and
nominee for director and by the officers of the Company named in the Summary
Compensation Table; and (3) by all current executive officers and directors of
the Company as a group. Unless otherwise noted, all addresses are care of: NaPro
BioTherapeutics, Inc., 6304 Spine Road, Unit A, Boulder, Colorado 80301.

<TABLE>
<CAPTION>

                                          NUMBER OF                            NUMBER OF
NAME OF DIRECTOR, OFFICER OR              SHARES OF         PERCENT OF         SHARES OF          PERCENT OF
BENEFICIAL OWNER(1)                     COMMON STOCK           CLASS        PREFERRED STOCK         CLASS
- ----------------------------            ------------        ----------      ---------------       ----------
<S>                                       <C>                   <C>            <C>                  <C> 
Leonard P. Shaykin                       1,182,742(2)(3)       13.1%               0                  0%

Sterling K. Ainsworth                    1,108,019(3)(4)       13.0%               0                  0%

Patricia A. Pilia                          290,079(3)(5)        3.4%               0                  0%

Gordon H. Link, Jr.                            19,167(6)         *                 0                  0%

Phillip Frost                                  10,000(7)         *                 0                  0%
c/o IVAX Corporation
8800 Northwest 36th Street
Miami, Florida 33178

Arthur H. Hayes, Jr.                                   0         0                 0                  0%

E. Garrett Bewkes, Jr.                         80,167(8)         *                 0                  0%

Vaughn D. Bryson                                       0         0                 0                  0%

Mark B. Hacken                                         0         0                 0                  0%

Richard C. Pfenniger, Jr.                      11,000(9)         *                 0                  0%
c/o IVAX Corporation
8800 Northwest 36th Street
Miami, Florida 33178

All Directors and Executive                2,908,140(10)       32.2%               0                  0%
Officers as a Group (13 persons)

D&N Holding Company                        1,126,398(3)(11)    13.2%               --                 --
c/o IVAX Corporation
8800 Northwest 36th Street
Miami, Florida 33178

Knowlton Brothers, Inc.                      557,100(12)        6.5%               --                 --
530 Fifth Avenue
New York, New York 10036

Mervyn Adelson Trust                         275,000(13)        3.3%          125,000               100% 
10100 Santa Monica Boulevard
Suite 1300
Los Angeles, California 90067
- ----------
* Less than 1%.

(1)   Unless otherwise noted, the Company believes that all persons named in the
      table have sole voting and investment power with respect to all shares of
      Common Stock or Preferred Stock beneficially owned by them.

                                       2
<PAGE>

(2)   Includes warrants to purchase 507,111 shares of Common Stock. Such
      warrants were purchased by Mr. Shaykin  from various third parties 
      unaffiliated with the Company and from D&N Holding Company ("D&N"), a
      wholly owned subsidiary of IVAX Corporation ("IVAX").

(3)   IVAX (through D&N), Mr. Shaykin, Dr. Ainsworth, Dr. Pilia and the Company
      are parties to an amended Stockholders Agreement dated as of June 7, 1993
      (the "Stockholders Agreement"), pursuant to which, among other things,
      each of such directors and IVAX is obligated to vote for the election of
      Dr. Ainsworth (as long as he owns beneficially (before taking into
      consideration any shares issuable upon exercise or conversion of
      outstanding options and warrants or convertible securities, respectively)
      10% or more of the outstanding Common Stock) and two individuals
      designated by IVAX to the Company's Board of Directors. These designees
      currently are Dr. Frost and Mr. Pfenniger. By virtue of this provision of
      the Stockholders Agreement, each of such directors and IVAX may be deemed
      to share the power to vote or direct the vote of the shares deemed
      beneficially owned by the parties to the Stockholders Agreement with each
      of the other parties to the Stockholders Agreement. Each of Mr. Shaykin,
      Dr. Ainsworth, Dr. Pilia and IVAX disclaims that it, he, or she and any
      one or more other parties to the Stockholders Agreement constitute a group
      under Rule 13d-5(b)(1) of the Act, pursuant to which such group may be
      deemed to beneficially own the shares directly beneficially owned by each
      of such directors and IVAX.

(4)   Includes 122,667 shares of Common Stock issuable upon exercise of non-plan
      options granted to Dr. Ainsworth in connection with the formation of the
      Company in 1991 and 42,550 shares of Common Stock gifted by Dr. Ainsworth
      to relatives and certain other persons, which Dr. Ainsworth may be deemed
      to beneficially own by virtue of holding powers of attorney to vote and
      take certain other actions with respect to such shares. Dr. Ainsworth, who
      is engaged to be married to Dr. Pilia, disclaims beneficial ownership of
      the shares of Common Stock beneficially owned by Dr. Pilia and the gifted
      shares over which Dr. Ainsworth holds powers of attorney.

(5)   Includes 36,800 shares of Common Stock issuable upon exercise of non-plan
      options granted to Dr. Pilia in connection with formation of the Company
      in 1991, 1,000 shares of Common Stock issuable upon exercise of warrants
      purchased by Dr. Pilia in the Company's initial public offering, and
      10,800 shares of Common Stock gifted by Dr. Pilia to relatives and certain
      other persons which Dr. Pilia may be deemed to beneficially own by virtue
      of holding powers of attorney to vote and take certain other actions with
      respect to such shares. Dr. Pilia disclaims beneficial ownership of shares
      of Common Stock beneficially owned by Dr. Ainsworth and the gifted shares
      over which Dr. Pilia holds powers of attorney. See note (4) above.

(6)   Includes 16,667 shares of Common Stock issuable upon the exercise of
      options granted to Mr. Link under the Company's 1993 Stock Option Plan and
      2,500 shares of Common Stock issuable upon the exercise of options granted
      to Mr. Link under the 1994 Plan.

(7)   Includes 10,000 shares of Common Stock issuable upon exercise of options
      granted to Mr. Frost under the 1994 Plan.

(8)   Includes 13,500 shares of Common Stock issuable upon exercise of options 
      granted to Mr. Bewkes under the 1994 Plan.

(9)   Includes 11,000 shares of Common Stock issuable upon exercise of options
      granted to Mr. Pfenniger under the 1994 Plan.

(10)  Includes an aggregate of 723,912 shares of Common Stock issuable upon
      exercise of warrants, non-plan options, and options granted under the 
      1993 Stock Option Plan and the 1994 Plan.

                                        3
<PAGE>

(11)  Information in the table as to beneficial ownership of Common Stock by 
      IVAX and D&N is based upon filings with the Company made on Schedule 13G
      by IVAX. Such shares are held directly by D&N. Mr. Pfenniger is an officer
      and director of D&N and Mr. Pfenniger and Dr. Frost are executive officers
      of IVAX, and the Company has been advised that Dr. Frost beneficially owns
      approximately 11.8 of IVAX's voting securities. Dr. Frost and Mr.
      Pfenniger disclaim beneficial ownership of the shares of Common Stock held
      by D&N.

(12)  Information in the table as to beneficial ownership of Common Stock by
      Knowlton Brothers, Inc. ("KBI") is based on a statement of ownership on
      Schedule 13D filed by and on behalf of KBI and a number of related
      entities, namely: The Family Partnership, L.P., The Frontier Partnership,
      L.P., Flagship Partners, Ltd., Family Partners & Co., Frontier Partners &
      Co., Knowlton Associates, Inc., Winthrop Knowlton ("WK"), Stanley Knowlton
      ("SK"), Christopher Knowlton, Hugh Knowlton Trust For The Benefit of Erica
      Knowlton and Margaret F. Knowlton, as Custodian for Craig Stanley Knowlton
      (collectively, the "Reporting Persons"). The Reporting Persons own
      beneficially an aggregate amount of 557,100 shares of Common Stock
      (including 125,000 shares that may be acquired upon conversion of shares
      of Convertible Preferred Stock of the Company and 600 shares that may be
      acquired upon exercise of warrants to purchase Common Stock), constituting
      approximately 6.5 % of the shares of the Common Stock outstanding. Based
      on such Schedule 13D, none of such Reporting Persons individually owns
      more than 5.0% of the outstanding Common Stock. As described in such
      Schedule 13D, KBI, WK and SK may be deemed to beneficially own greater
      than 5.0% percent of the outstanding Common Stock based on the
      relationships among the Reporting Persons. According to such Schedule 13D,
      the Reporting Persons have acquired such 557,100 shares of Common Stock
      solely for investment and the Reporting Persons have no plans to seek
      control of the Company.

(13)  Includes 110,000 shares of Common Stock and warrants to purchase 40,000
      shares of Common Stock, and 125,000 shares of Convertible Preferred 
      Stock, Series A which is convertible into Common Stock.  Mervyn Adelson, 
      a trustee of the Mervyn Adelson Trust, is deemed to beneficially own the 
      Preferred Stock.


</TABLE>

                                       3

<PAGE>

                        PROPOSAL 1: ELECTION OF DIRECTORS

      The Company's Board of Directors currently consists of nine members: 
namely, Leonard P. Shaykin (Chairman); Sterling K. Ainsworth, Ph.D.; Patricia A.
Pilia, Ph.D.; E. Garrett Bewkes, Jr.; Richard C. Pfenniger, Jr.; Phillip Frost,
M.D.; Arthur H. Hayes, Jr., M.D.; Mark B. Hacken; and Vaughn D. Bryson. The
terms of office of all nine members of the Board of Directors expire at the
Annual Meeting.

      If the proposed amendments to the Company's Amended and Restated
Certificate of Incorporation set forth in Proposal 2 are adopted, the Company's
directors will be divided into three classes and three directors will be elected
at the Annual Meeting for a term expiring at the 1997 annual meeting of
stockholders, three directors will be elected for a term expiring at the 1998
annual meeting of stockholders and the remaining three directors will be elected
for a term expiring at the 1999 annual meeting of stockholders (or, in each
case, until their respective successors are duly elected and qualified). If such
proposed amendments are not adopted, all nine nominees will be elected for a
term expiring at the 1997 annual meeting of stockholders (or, in each case,
until their respective successors are duly elected and qualified). Unless
otherwise indicated on any proxy, shares represented by proxies will be voted
for all of the nominees, if Proposal 2 is approved, as follows: Mr. Shaykin and
Drs. Frost and Hayes for a term expiring at the 1997 annual meeting of
stockholders; Dr. Pilia and Messrs. Bewkes and Bryson for a term expiring at the
1998 annual meeting of stockholders; and Dr. Ainsworth and Messrs. Hacken and
Pfenniger for a term expiring at the 1999 annual meeting of stockholders; or, if
Proposal 2 is not approved, to a term expiring at the 1997 annual meeting of
stockholders as described above.

      Each person nominated has agreed to serve if elected, and management has
no reason to believe that any of the nominees will be unavailable for service.
Shares represented by executed proxies will be voted, if authority to do so is
not withheld, for the re-election of these nine nominees. If any nominee should
become unavailable for election due to an unexpected occurrence, such shares
will be voted for the election of a substitute nominee as the current Board of
Directors may propose.


CLASS I DIRECTORS

      LEONARD P. SHAYKIN, 52, has served as Chairman of the Board since June
1993. Pursuant to his Executive Agreement, Mr. Shaykin is not required to devote
more than 20 hours in any week nor more than 80 hours in any month to the
Company's affairs. In 1995, Mr. Shaykin founded Shaykin & Company, a private
investment holding firm. Prior to founding Shaykin & Company, Mr. Shaykin served
as founding and managing partner in Adler & Shaykin, an equity investment
partnership organized to sponsor leveraged buyouts. Prior thereto, Mr. Shaykin
was Vice President, director and a member of the Investment Committee of
Citicorp Venture Capital, Ltd. and Citicorp Capital Investors, Inc., the venture
capital and equity investment subsidiaries of Citicorp and Citibank. Mr. Shaykin
is Chairman of the Board of Directors of Kimeragen, Inc., a privately held gene
repair company, a director of Avigen, a public gene therapy company, Chairman of
the Neuroblastoma Foundation and a director of the Jerusalem Post, an
English-language offshore newspaper. Mr. Shaykin is also a governing trustee of
The Jackson Laboratories, a not for profit genetic research institute, and a
trustee of the University of Chicago Graduate School of Business. Mr. Shaykin is
a graduate of the University of Chicago (B.A., M.A., M.B.A.).

      PHILLIP FROST, M.D., 59, has served as a director of the Company since
June 1993. Dr. Frost has served as Chairman and Chief Executive Officer of IVAX
since 1987, and as President of IVAX from July 1991 to January 1995. He is the
Vice Chairman of the Board of Directors of North American Vaccine, Inc. Dr.
Frost was the Chairman of the Department of Dermatology at Mt. Sinai Medical
Center of Greater Miami, Miami Beach, Florida, from 1972 to 1990. He was
Chairman of the Board of Directors of Key Pharmaceuticals, Inc. from 1972 to
1986. He is a director of American Exploration Company (an oil and gas
exploration and production company), Northrup Grumman Corp., and Whitman
Education Group, Inc. He is a trustee of the University of Miami and a member of
the Board of Governors of the American Stock Exchange.

                                       4

<PAGE>

      ARTHUR H. HAYES, JR., M.D., 63, was appointed a director of the Company in
March 1996. He is currently President and Chief Operating Officer of MediScience
Associates, Inc., a pharmaceutical consulting company and is a Professor of
Medicine at New York Medical College and Pennsylvania State University College
of Medicine. From 1981 to 1983, Dr. Hayes served as the Commissioner of the FDA.
From 1986 to 1991, he was President and Chief Executive Officer of EM
Pharmaceuticals, as well as a member of the board of directors. Dr. Hayes served
as Provost & Dean at New York Medical College from 1983 to 1986, and served as
the Director of the Institute of Human Values in Medical Ethics, International
Health and Biomedical Sciences, the latter of which he also served as Chairman.
Dr. Hayes has held several posts with Pennsylvania State University which
included Professor of Medicine and Pharmacology from 1977 to 1981, Dean of
Admissions from 1976 to 1979 and Associate Professor of Medicine and
Pharmacology and Director of the Division of Clinical Pharmacology from 1972 to
1977. Dr. Hayes currently serves on the board of directors of Myriad Genetics,
Inc. (a genomic research and pharmaceutical company) and of Celgene Corporation
(a pharmaceutical company). Dr. Hayes received his M.D. from Cornell University
Medical College, and also attended Cornell's Graduate School of Medical
Sciences, Department of Pharmacology. He undertook premedical studies and
attended medical school at Georgetown University. Dr. Hayes received his M.A.
(Philosophy, Politics and Economics) from Oxford University, where he was a
Rhodes Scholar, and his A.B. (Philosophy) from Santa Clara University in 1955.


CLASS II DIRECTORS

      E. GARRETT BEWKES, JR., 68, has served as a director of the Company since
September 1993. Since April 1987, Mr. Bewkes has been a director of PaineWebber
Group, Inc. and a consultant and Chairman of a number of PaineWebber mutual
funds. From 1982 until 1987 he was Chairman of American Bakeries Corp. and
currently serves as a director of Interstate Bakeries Corp.

      VAUGHN D. BRYSON, 56, was appointed a director of the Company in March 
1996. Vaughn Bryson has been Vice Chairman of Vector Securities International,
Inc. ("Vector"), a specialty health care investment banking firm, since April
1994. Prior to joining Vector, Mr. Bryson worked in various positions for Eli
Lilly and Company for 32 years, including in sales/market research, human
resources, distribution, sales management and new product planning. Mr. Bryson
served as Eli Lilly's President and Chief Executive Officer from 1991 until June
1993. Mr. Bryson was a director of Eli Lilly from 1984 until his retirement in
1993. Mr. Bryson is a Director of three public companies, ARIAD Pharmaceuticals,
Inc., Endo Vascular Technologies, Inc. and Perclose, Inc. Mr. Bryson earned a
B.S. in Pharmacy from the University of North Carolina and completed the
Stanford Sloan Program at Stanford University Graduate School of Business.

      PATRICIA A. PILIA, PH.D., 47, a co-founder of the Company, has served as a
director of the Company since its inception. She was appointed Secretary of the
Company in November 1991, Treasurer of the Company in October 1992 and Vice
President of BioResearch and Toxicology in March 1993. In 1990, she co-founded,
with Dr. Ainsworth, Pacific Biotechnology, Inc. (a predecessor of the Company)
and served as its Vice President and Director of Biotechnology. From 1983 to
1991, Dr. Pilia was an Assistant Professor of Pathology in the College of
Medicine and Dental Medicine and the College of Graduate Studies at the Medical
University of South Carolina ("MUSC"). Dr. Pilia served as the Assistant
Director of the MUSC Immunopathology Diagnostic and Research Laboratories from
1985 to 1991. Since 1984 she has been a consultant to industry on the design and
development of biomedical devices and treatment modalities and the design and
performance of clinical trials. Dr. Pilia received a Bachelor's degree in 1970
from Boston University, a Master's degree in Immunology/Microbiology in 1978 and
a Doctoral degree in Pathology in 1980 from MUSC. Dr. Pilia is engaged to marry
Dr. Ainsworth, a director and chief executive officer of the Company.


CLASS III DIRECTORS

      STERLING K. AINSWORTH, PH.D., 56, a co-founder of the Company, has served
as an executive officer and director of the Company since its inception, as
Chief Executive Officer since November 1991, and as 

                                      5
<PAGE>

as President since October 1992. In 1990, he co-founded, with Dr. Pilia, Pacific
Biotechnology, Inc. and served as Chairman and President of such company until
the Company's inception. From 1972 until 1990, Dr. Ainsworth held various levels
of professorships of Pathology with tenure in the College of Medicine and Dental
Medicine and Graduate Studies at MUSC, where he established, developed and
directed MUSC's Immunopathology Diagnostic Laboratory. Dr. Ainsworth received a
Bachelor's degree from the University of Mississippi in 1963. He received a
Master's degree in Medical Microbiology in 1965 and a Doctoral degree in Medical
Science in 1969 from the University of Mississippi Medical School. He completed
his post-doctoral fellowship in the Department of Pathology at Harvard Medical
School from 1970 to 1972. Dr. Ainsworth is engaged to marry Dr. Pilia, a
director and officer of the Company.

      MARK B. HACKEN, 60, was appointed a director of the Company in March 1996.
He is currently President of MBH International, a retail and health care
consulting company. He is the former Chief Executive Officer of FHP
International Corporation ("FHP International"), a $4 billion HMO with members
in 11 states, and its operating subsidiary, FHP Incorporated ("FHP
Incorporated"), a diversified health care services company. Prior to his
appointment to the Office of the Chief Executive in October 1993, he served on
the board of directors of FHP International and of FHP Incorporated for two
years and seven years, respectively. He was co-founder and President of Elliott
Drugs, and President of Drug King after the firm was acquired from DART
Industries. After Drug King was sold to Thrifty Corporation, he was instrumental
in converting them to the Thrifty Jr. drug store concept and he was President of
that division.  Mr. Hacken received a B.S. in Pharmacy from the University of
Florida.

      RICHARD C. PFENNIGER, JR., 40, has served as a director of the Company
since June 1993. Mr. Pfenniger has served as Chief Operating Officer of IVAX
since April 1994. He served as Senior Vice President-Legal Affairs, Secretary
and General Counsel of IVAX from 1989 until April 1994, and as Secretary of IVAX
from 1990 until April 1994. For during the seven-year period prior to joining
IVAX, Mr. Pfenniger was engaged in private law practice, most recently as a
member of the law firm of Greer, Homer & Bonner, P.A. in Miami, Florida. Mr.
Pfenniger is a director of Whitman Education Group, Inc. and North American
Vaccine, Inc.

MANAGEMENT AND THE BOARD OF DIRECTORS RECOMMEND A VOTE FOR EACH NOMINEE FOR
RE-ELECTION TO THE BOARD.


OTHER EXECUTIVE OFFICERS

      LAWRENCE HELSON, M.D., 65, joined the Company as a director and in the
part-time position of Vice President, Clinical Research in July 1993. Dr. Helson
served as a director of the Company until March 1996. Since July 1988, Dr.
Helson has been head of the Neuro-Oncology Laboratory in the Division of
Neoplastic Diseases, Department of Medicine at New York Medical College. From
July 1986 until June 1988, Dr. Helson was an Associate Director with ICI
Pharmaceuticals. From July 1968 until June 1986, Dr. Helson was an attending
physician with Memorial Sloan-Kettering, a cancer research center. Pursuant to
his Executive Agreement, Dr. Helson is not required to devote more than 15 hours
in any week nor more than 60 hours in any month to the Company's affairs. Dr.
Helson received his B.S. from the College of the City of New York in 1953, his
M.S. from the New York University Graduate School of Arts and Sciences in 1957
and his M.D. from the University of Geneva (Switzerland) Medical School in 1962.

      GORDON H. LINK, JR., 42, a certified public accountant and a certified
management accountant, joined the Company as Vice President, Finance and Chief
Financial Officer in September 1993. Prior thereto, Mr. Link served concurrently
as Corporate Controller of Synergen, Inc. and of the Syntex-Synergen
Neuroscience Joint Venture. From February 1991 until April 1993, Mr. Link was
Treasurer of Synergen Development Corporation. From October 1983 through May
1990, Mr. Link practiced as a certified public accountant, most recently in the
position of Audit Manager with Deloitte & Touche. He received undergraduate
degrees in chemistry from Rensselaer Polytechnic Institute in 1976 and in
accounting from Metropolitan State College in 1983.

                                       6

<PAGE>

      DAVID L. DENNY, 44, has served as Vice President, Operations of the
Company since September 1995. From 1991 to 1993, Mr. Denny served as
Vice President of Operations for Somatogen, Inc. Prior thereto, Mr. Denny served
in manufacturing and quality assurance capacities with Miles Pharmaceutical,
Abbott Laboratories and Kabi-Pharmacia. He received a B.S. in Biological
Sciences from Tennessee Technological University in 1972 and attended graduate
school at the same institution from 1972 to 1974.

      JAMES D. MCCHESNEY, PH.D., 56, joined the Company as Vice President of 
Natural Products Chemistry in January 1996. From 1987 until June 1995, he served
as Director of the Research Institute of Pharmaceutical Sciences at the
University of Mississippi, specializing in natural product pharmaceutical
research and development. In July 1993, Dr. McChesney was named Frederick A.P.
Barnard Distinguished Professor of Pharmacognosy at the University of
Mississippi. Dr. McChesney joined the School of Pharmacy at the University of
Mississippi in 1978 as Professor and Chair of the Department of Pharmacognosy.
After graduating with honors from Iowa State University in 1961 with a B.S. in
Chemical Technology, he earned degrees in Botany (M.A. 1964) and Natural
Products Chemistry (Ph.D. 1965) at Indiana University. He has been a Fulbright
Lecturer in Brazil and a Visiting Professor at several South American
universities.

BOARD MEETINGS AND COMMITTEES

      The Board of Directors held four meetings during 1995, including both
regularly scheduled and special meetings.

      The Board of Directors has established an Audit Committee, a Compensation
Committee and a Strategic Planning Committee. The Audit Committee, which
currently consists of Mr. Hacken, Chairman, and Mr. Bewkes, meets periodically
with representatives of the Company's independent auditors and the Company's
management to obtain an assessment of the Company's financial condition and
results of operations, the results and scope of the annual audit and other
services provided by the Company's independent auditors, and reports to the full
Board of Directors with respect thereto. The Audit Committee met two times
during 1995. The Compensation Committee, which currently consists of Mr. Bewkes,
Chairman, Mr. Bryson and Mr. Pfenniger, meets periodically to review and to
recommend to the full Board of Directors compensation arrangements for senior
management and directors. In addition, the Compensation Committee is responsible
for administering the Company's existing stock option plans. The Compensation
Committee met once during 1995. The Strategic Planning Committee, which
currently consists of Mr. Bryson, Chairman, Mr. Shaykin, Dr. Ainsworth, Mr.
Pfenniger and Dr. Hayes, meets periodically to review the Company's strategic
plans in connection with product development and marketing, regulatory
approvals, clinical testing and other matters. The Strategic Planning Committee
did not meet during 1995. Each director attended more than 75% of the aggregate
number of board and/or applicable committee meetings in 1995.

                                       7

<PAGE>

COMPENSATION OF EXECUTIVE OFFICERS

      EXECUTIVE COMPENSATION

      The following table sets forth compensation paid to Dr. Ainsworth, Mr. 
Shaykin, Dr. Pilia and Mr. Link.  None of the Company's other executive officers
had annual compensation in excess of $100,000 for services rendered during
the fiscal year ended December 31, 1995.
<TABLE>

                                            SUMMARY COMPENSATION TABLE
<CAPTION>


                                            Annual Compensation                    Long-Term Compensation
                                     ------------------------------------------------------------------------------
                                                                                       Awards               Payouts
                                                                              -------------------------------------

                                                                                             SECURITIES
                                                                 OTHER                       UNDER-
                                                                 ANNUAL        RESTRICTED    LYING                        ALL OTHER
NAME AND PRINCIPAL                                             COMPENSA-         STOCK       OPTIONS/      LTIP           COMPENSA-
POSITION                 YEAR     SALARY ($)    BONUS($)        TION($)        AWARDS($)     SARS(#)       PAYOUTS($)     TION ($)
- ----------------------- -------- ------------  ------------ --------------  --------------  ------------- -------------  ----------
<S>                       <C>       <C>            <C>             <C>            <C>            <C>            <C>           <C>
Sterling K. Ainsworth    1995     $152,077        $20,000          0            $20,000         40,000         0              0
President and C.E.O.     1994      138,111           0             0               0               0           0              0
                         1993       99,769           0             0               0               0           0              0
Leonard P. Shaykin       1995     $152,077        $20,000          0            $20,000        100,000(1)      0              0
Chairman of the Board    1994      106,192           0             0               0               0           0              0
                         1993       51,402           0             0               0               0           0              0
Patricia A. Pilia        1995     $116,592        $15,000          0            $15,000         20,000         0              0
Vice President,          1994       96,077           0             0               0               0           0              0
Secretary and            1993       73,662           0             0               0               0           0              0
Treasurer

Gordon H. Link, Jr.      1995     $101,385        $10,000          0            $10,000         10,000         0              0
Chief Financial          1994       92,480           0             0               0            16,667         0              0
Officer                  1993       28,454           0             0               0            26,667         0              0
- -----------
(1)  Includes option to purchase 50,000 shares of Common Stock granted in
     October 1995, subject to approval of stockholders of amendments to the
     1994 Plan.

      The following table sets forth each grant of options to purchase Common 
Stock made during the year ended December 31, 1995, to Dr. Ainsworth, Mr.
Shaykin, Dr. Pilia and Mr. Link. Grants of options to such executive officers
were made under the 1994 Plan:


                        OPTION GRANTS IN LAST FISCAL YEAR
<CAPTION>

                                                                                               POTENTIAL REALIZABLE       
                            NUMBER OF       % OF TOTAL                                    VALUE AT ASSUMED ANNUAL RATES OF     
                           SECURITIES        OPTIONS                                        STOCK PRICE APPRECIATION FOR       
                           UNDERLYING       GRANTED TO    EXERCISE OR BASE                      OPTION TERMS ($)(4)            
                             OPTIONS       EMPLOYEES IN    PRICE PER SHARE    EXPIRATION      
 NAME                     GRANTED (#)(1)   FISCAL YEAR(2)     ($/SH)          DATE(3)            5%               10%         
- ------------------------ ---------------  --------------  -----------------  -------------    ---------       ----------       
<S>                           <C>              <C>              <C>             <C>             <C>             <C>  
Sterling K. Ainsworth        40,000           11.83%           $10.125         11/15/05       659,702         1,050,466   
Leonard P. Shaykin          100,000(5)        29.57%           $10.125         11/15/05     1,649,256         2,626,164        
Patricia A. Pilia            20,000            5.91%           $10.125         11/15/05       329,851           525,233         
Gordon H. Link, Jr.          10,000            2.96%           $10.125         11/15/05       164,926           262,616
- -----------                                                                                           
(1)   Options granted under the 1994 Plan become exercisable at the rate of 25%              
      of the shares subject to the option one year after the date of grant and
      25% of the shares subject to the option each year thereafter.
(2)   Based on the aggregate of 338,125 options granted under the 1994 Plan in 
      1995 to employees of the Company, including the named executive officers.
(3)   These options have a 10-year term, subject to earlier termination upon
      death, disability or termination of employment.

                                       8

<PAGE>

(4)   The potential realizable value is calculated based on the term of the 
      option at its time of grant (10 years) assuming that the stock price on
      the date of grant appreciates at the indicated annual rate compounded
      annually for the entire term of the option and that the option is
      exercised and sold on the last day of its term for the appreciated stock
      price. No gain to the optionee is possible unless the stock price
      increases over the option term, which will benefit all stockholders.
(5)   Includes option to purchase 50,000 shares of Common Stock granted on 
      October 1995, sibject to approval of stockhoders of amendments to the 
      1994 Plan.

      The following table sets forth information concerning outstanding options 
held by Dr. Ainsworth, Mr. Shaykin, Dr. Pilia and Mr. Link as of the fiscal year
ended December 31, 1995.



             AGGREGATED OPTION/SAR EXERCISES IN LAST FISCAL YEAR AND
                        FISCAL YEAR-END OPTION/SAR VALUES
<CAPTION>

                                NUMBER OF SECURITIES UNDERLYING                 VALUE OF UNEXERCISED
                            UNEXERCISED OPTIONS/SARS AT FISCAL YEAR   IN-THE-MONEY OPTIONS/SARS AT FISCAL YEAR
                                            END(#)                                    END($)(3)
           NAME                    EXERCISABLE/UNEXERCISABLE                  EXERCISABLE/UNEXERCISABLE
- -------------------------- ----------------------------------------- -------------------------------------------
<S>                                     <C>                                         <C>
Sterling K. Ainsworth                122,667 / 40,000                            $1,127,003 / $0
President and C.E.O.

Leonard P. Shaykin                         0 / 100,000(1)                                $0 / $0
Chairman of the Board

Patricia A. Pilia                     36,800 / 20,000                              $338,100 / $0
Vice President,
Secretary and Treasurer

Gordon H. Link, Jr.                19,167(2) / 34,167                              $146,465 / $162,890
Chief Financial Officer
- ----------
(1)   Includes option to purchase 50,000 shares of Common Stock granted in
      November 1995, subject to approval of stockholders of amendments to the
      1994 Plan.
(2)   Includes options to purchase 1,667 shares of Common Stock that vested on 
      April 10, 1996.
(3)   Represents the difference between the option exercise price and the
      closing price of the Common Stock as quoted on the Nasdaq Small Cap on
      December 29, 1996 ($9.38), multiplied by the corresponding number of
      underlying shares.
</TABLE>

COMPENSATION OF DIRECTORS

      Pursuant to the 1994 Plan, non-employee directors automatically are
granted each year, on the date of the Company's annual meeting of stockholders,
non-qualified options to purchase 5,000 shares of Common Stock. In addition, any
non-employee director who is first appointed or elected other than at an annual
meeting of stockholders automatically receives non-qualified options to purchase
5,000 shares of Common Stock upon such appointment or election. All such options
are exercisable at an exercise price equal to the fair market value of the
Common Stock on the date of grant and are subject to certain vesting schedules.
For a description of the 1994 Plan, see " --1994 Long- Term Performance
Incentive Plan."

      Contingent upon approval by the stockholders, the Board of Directors has
adopted amendments to the 1994 Plan to (i) increase the number of shares of
Common Stock underlying automatic annual grants of non-qualified stock options
to non-employee directors from 5,000 to 10,000 shares and (ii) provide for
automatic annual grants of non-qualified stock options to purchase 10,000 shares
of Common Stock to directors who serve as chair of the Audit, Compensation and
Strategic Planning Committees of the Board of Directors. Automatic grants
associated with such amendments will be effective on the next business day
following the annual meeting, subject to approval of the proposed amendments.
See Proposal 3.

      Directors are reimbursed for their costs incurred in attending Board of
Directors meetings.

                                       9
<PAGE>

EMPLOYMENT AGREEMENTS AND TERMINATION OF EMPLOYMENT ARRANGEMENTS

      The Company entered into an Employment and Executive Stock Agreement with
each of Mr. Shaykin and Drs. Ainsworth, Pilia and Helson (collectively, the
"Senior Executives"), effective as of June 7, 1993, and amended and restated
effective as of May 31, 1994 (collectively, the "Executive Agreements"). Each
Executive Agreement provides for an initial five-year employment term that
expires June 7, 1998 (the "Initial Term"), and is renewable each year thereafter
(each, a "Renewal Term"), unless either party gives notice of termination to the
other party at least 180 days prior to the commencement of any Renewal Term.

      The Executive Agreements provide for annual base salaries for Mr. Shaykin
and Drs. Ainsworth, Pilia and Helson of $150,000, $150,000, $115,000 and $75,000
respectively. Under the Executive Agreements, the Senior Executives may be
granted annual bonuses at the discretion of the Board's Compensation Committee.
In addition, $59,573 and $43,932 of unpaid salaries were deferred between March
1991 and December 1992 by Drs. Ainsworth and Pilia, respectively, in light of
the Company's financial condition. Mr. Shaykin and Dr. Helson are part-time
employees of the Company, and are not required under their respective Executive
Agreements to spend more than 20 and 15 hours in any week or 80 and 60 hours per
month on the Company's affairs, respectively.

      Each Executive Agreement provides for certain benefits if, prior to the
end of the Initial Term or any Renewal Term, a Senior Executive's employment is
terminated either by the Company other than for Cause (as defined in the
Executive Agreements) or by the Senior Executive for Good Reason (as defined in
the Executive Agreements). In general, each Senior Executive would be entitled
to (i) a continuance of their respective salary and bonus, if any, through the
end of the Initial Term (but in no event for longer than three years in the case
of Mr. Shaykin and Dr. Helson) or the then-current Renewal Term, if applicable,
and (ii) health and welfare benefits as in effect immediately prior to
termination for a maximum of 18 months following termination. The foregoing
benefits would be limited by the amount deductible for income tax purposes under
the Internal Revenue Code of 1986, as amended (the "Code").

      The Executive Agreements also contain provisions (i) prohibiting
disclosure of confidential information, (ii) granting to the Company rights to
intellectual property developed by the Senior Executives that relate to the
Company's business or developed in the course of employment with the Company (or
that otherwise relate in any way to health care or pharmaceuticals, in the case
of Drs. Ainsworth and Pilia), and (iii) prohibiting competition with the Company
during and for five years after the Senior Executive's employment.

      Under the Executive Agreements, Mr. Shaykin and Drs. Ainsworth, Pilia and
Helson acquired 531,864, 578,592, 150,428 and 265,932 shares of Common Stock,
respectively (the "Executive Stock"). The purchase price for such shares was
$1.50 per share and is represented by promissory notes in favor of the Company
(collectively, the "Executive Notes"). The Executive Notes, which were amended
effective as of May 31, 1994, bear interest at the greater of (i) the prime rate
minus 1% (9% as of June 1995) and (ii) the applicable federal rate (set annually
on June 7). Principal and interest on the Executive Notes are due and payable
upon the receipt of proceeds from a Senior Executive's transfer of any shares of
Executive Stock, in the full amount of such proceeds. Notwithstanding the
foregoing, the outstanding principal amount of, and accrued and unpaid interest
under, an Executive Note shall become immediately due and payable upon the
earliest to occur of (i) the Sale of the Company (as defined in the Executive
Agreements), (ii) the termination of a Senior Executive's employment by the
Company for Cause (as defined in the Executive Agreement), by the Senior
Executive other than for Good Reason (as defined in the Executive Agreement), or
by reason of a Senior Executive's death, disability or incapacity, and (iii) the
Senior Executive's failure to pay any principal or interest within 15 days of
the date due.

      The shares of Common Stock acquired by each Senior Executive were pledged
to the Company pursuant to a pledge agreement as security for payment of such
Senior Executive's Executive Note. In

                                       10
<PAGE>

addition, the Executive Notes provide for recourse against the respective Senior
Executives to the extent of 25% of the then outstanding principal amount. The
Executive Agreements also contain provisions restricting the transfer of
Executive Stock and requiring the Senior Executives to sell their Executive
Stock under certain circumstances if the Board approves a Sale of the Company.

      Commencing May 9, 1995, each Senior Executive became able to repay all or
part of the outstanding principal and/or interest on his or her Executive Note
by remitting to the Company shares of his or her Common Stock, to be valued for
such purposes in an amount equal to the average of the last reported sales price
of the Common Stock for the five trading days prior to remittance multiplied by
the number of shares remitted. During 1995, each of Drs. Ainsworth, Pilia and
Helson remitted shares of Common Stock to the Company in exchange for
extinguishment of the debt represented by their respective Executive Notes. See
" --Certain Relationships and Related Transactions-- Indebtedness of
Management."


1994 LONG-TERM PERFORMANCE INCENTIVE PLAN

      In May 1994, the Company's Board of Directors adopted the 1994 Long-Term
Performance Incentive Plan which was subsequently approved by the stockholders
of the Company prior to the Company's initial public offering in August 1994.
The 1994 Plan provides for granting to employees and other key individuals who
perform services for the Company ("Participants") the following types of
incentive awards: stock options, stock appreciation rights ("SARs"), restricted
stock, performance units, performance grants and other types of awards that the
Compensation Committee deems to be consistent with the purposes of the 1994
Plan. The 1994 Plan also provides non-employee directors with stock option
grants according to an established formula.

      The 1994 Plan affords the Company latitude in tailoring incentive
compensation to support corporate and business objectives, to anticipate and
respond to a changing business environment and competitive compensation
practices and, in the case of options granted to non-employee directors, to
strengthen further the non-employee directors' linkage with stockholder
interests.

      The following is a description of the principal features of the 1994 Plan.

      ADMINISTRATION. The Compensation Committee has exclusive discretion to
select the Participants and to determine the type, size and terms of each award,
to modify the terms of awards, to determine when awards will be granted and
paid, and to make all other determinations which it deems necessary or desirable
in the interpretation and administration of the 1994 Plan. The 1994 Plan
terminates ten years from the date that it is initially approved and adopted by
the stockholders of the Company, unless extended for up to an additional five
years by action of the Board of Directors. With limited exceptions, including
termination of employment as a result of death, disability or retirement, or
except as otherwise determined by the Compensation Committee, rights to these
forms of contingent compensation will be forfeited if a recipient's employment
or performance of services terminates within a specified period following the
award. Generally, a Participant's rights and interest under the 1994 Plan will
not be transferable except by will or by laws of descent and distribution.

      AWARDS. Under the 1994 Plan, Participants are granted incentive awards
consisting of stock options, SARs, restricted stock, performance units,
performance grants and other types of awards.

         STOCK OPTIONS. Participants are granted stock options which include
non-qualified stock options and incentive stock options. Stock options are
rights to purchase a specified number of shares of Common Stock at a price fixed
by the Compensation Committee. The option price may not be less than the fair
market value of the underlying shares of Common Stock on the date of grant. In
the case of purchased stock options, a specified number of non-qualified stock
options (with an option price as described above) will be offered for grant to
selected Participants in exchange for a purchase price, specified by the
Compensation Committee, which is payable at the time of grant. Options generally
will expire not later than ten years after the date on which they are granted.
Options will become

                                       11

<PAGE>

exercisable at such times and in such installments as the Compensation Committee
shall determine. Payment of the option price must be made in full at the time of
exercise in such form (including, but not limited to, cash, Common Stock or the
surrender of another outstanding award or any combination thereof) as the
Compensation Committee may determine. Federal income tax payable as a
consequence of the exercise of such options is borne by the grantee.

         SARS. SARs may be granted alone, or a holder of an option or other
award may be granted a related SAR, either at the time of grant or by amendment
thereafter. Upon exercise of an SAR, the holder must surrender the SAR and
surrender, unexercised, any related option or other award, and the holder will
receive in exchange, at the election of the Compensation Committee, cash or
Common Stock or other consideration, or any combination thereof, equal in value
to (or, in the discretion of the Compensation Committee, less than) the
difference between the exercise price or option price per share and the fair
market value per share of Common Stock on the last business day preceding the
date of exercise, times the number of shares subject to the SAR or option or
other award, or portion thereof, which is exercised.

         RESTRICTED STOCK AWARDS. A restricted stock award is an award of a
specified number of shares of Common Stock which are subject to a restriction
against transfer and to a risk of forfeiture during a period set by the
Compensation Committee. During the restriction period, the Participant generally
has the right to vote and receive dividends on the shares.

         PERFORMANCE GRANTS AND OTHER AWARDS. Performance grants are awards with
a final value, if any, that is determined by the degree to which specified
performance objectives have been achieved during an award period set by the
Compensation Committee, subject to such adjustments as the Compensation
Committee may approve based on relevant factors. Performance objectives are
based on such measures of performance, including, without limitation, measures
of industry, the Company, unit or Participant performance, or any combination of
the foregoing, as the Compensation Committee may determine. The Compensation
Committee may make such adjustments in the computation of any performance
measure as it may deem appropriate. A target value of an award will be
established (and may be amended thereafter) by the Compensation Committee and
may be a fixed dollar amount, an amount that varies from time to time based on
the value of a share of Common Stock, or an amount that is determinable from
other criteria specified by the Compensation Committee. Payment of the final
value of an award will be made as promptly as practicable after the end of the
award period or at such other time or times as the Compensation Committee may
determine. The 1994 Plan permits the grant of any other type of incentive
compensation award determined by the Compensation Committee to be consistent
with the purposes of the 1994 Plan.

      FORMULA PLAN FOR NON-EMPLOYEE DIRECTORS. The 1994 Plan provides that each
person who is not an employee of the Company or one of its subsidiaries and who
is elected or re-elected as a director of the Company by the stockholders at any
annual meeting of stockholders, and, if first elected or appointed other than at
an annual meeting, upon such election or appointment, will receive, as of the
next business day following the date of each such election or appointment a
non-qualified option to purchase a specified number of shares of the Company's
Common Stock. Currently, non-employee directors are entitled to receive an
option for 5,000 shares of Common Stock under such automatic provisions. The
Board of Directors has approved an amendment to the 1994 Plan to increase the
number of shares subject to such automatic grant of options from 5,000 to
10,000, subject to stockholder approval. The Board of Directors has also
approved an amendment to such formula provisions, subject to stockholder
approval, to provide automatic annual grants of options to purchase 10,000
shares of Common Stock to the chair of the Audit, Compensation and Strategic
Planning Committees of the Board of Directors. Each option granted to
non-employee directors will have an option price equal to the fair market value
of the Company's Common Stock on the date of grant, will generally become
exercisable in full on the first anniversary following the date of grant and
will have a term of 10 years from the date of grant.

      LIQUIDATION, CHANGES IN CONTROL; MERGERS. Upon the liquidation or
dissolution of the Company, all outstanding awards under the 1994 Plan will
terminate immediately prior to the consummation of

                                       12
<PAGE>

such liquidation or dissolution, unless otherwise provided by the Compensation
Committee. Upon certain events, including (i) any "person,"as such term is used
in Sections 13(d) and 14(d) of the Exchange Act, including a "group" as defined
in Section 13(d) of the Exchange Act but excluding the Company and any
subsidiary and any employee benefit plan sponsored or maintained by the Company
or any subsidiary (including any trustee of such plan acting as trustee),
directly or indirectly, becoming the "beneficial owner" (as defined in Rule
13d-3 under the Exchange Act, as amended from time to time), of securities of
the Company representing 25% or more of the combined voting power of the
Company's then outstanding securities; (ii) individuals who at the beginning of
any 12-month period constituted the Board ceasing for any reason other than
death to constitute a majority of such Board; or (iii) approval by the Company's
stockholders of a transaction involving the acquisition of the Company by an
entity other than the Company or any subsidiary through purchase of assets, by
merger, or otherwise, (A) any SARs and any options will become immediately
exercisable in full; (B) restrictions and deferral limitations applicable to any
restricted stock and other awards payable in shares of Common Stock will lapse
and become immediately exercisable in full; (C) generally, outstanding
performance grants will become vested and will be paid out based on the prorated
target results for the awards period in question; and (D) generally, the value
of all outstanding options, SARs, restricted stock, performance grants and any
other type of award payable in shares of Common Stock will be cashed out.

      AMENDMENT AND TERMINATION. The Board may amend or suspend the 1994 Plan in
whole or in part at any time provided that stockholder approval is obtained
where failure to obtain such approval would adversely affect the compliance of
the 1994 Plan with Rule 16b-3 under the Exchange Act and with other applicable
law. The 1994 Plan will terminate on June 16, 2004, unless sooner terminated by
the Board. No amendment or termination of the Plan may materially affect any
rights of a Participant with respect to any Award without the written consent of
the Participant except where, in the Compensation Committee's discretion, it
determines that significant changes in the Participant's position, duties or
responsibilities, or significant changes in economic, legislative, regulatory,
tax, account or cost/benefit conditions have had or will have a substantial
effect on the performance of the Company or any of its subsidiaries or
affiliates.

      FEDERAL INCOME TAX CONSEQUENCES OF AWARDS UNDER THE 1994 PLAN. The tax
consequences applicable to the Company and to a Participant in the 1994 Plan in
connection with an incentive stock option, non-qualified option, SAR, restricted
stock award, performance grant or other stock-based award granted to a
participant, or bonuses or other compensation paid in stock under the 1994 Plan
are complex and depend, in large part, on the surrounding facts and
circumstances. The following brief summary of certain significant United States
federal income tax consequences under existing law of the 1994 Plan is not
intended to be exhaustive and, among other things, does not describe state,
local or foreign tax consequences.

      Under the Code, the grant of a stock option does not result in taxable
income to the optionee or any tax deduction to the Company. However, the
transfer of common stock of the Company to an optionee upon exercise of an
option may or may not give rise to taxable income to the optionee and tax
deductions to the Company, depending upon whether or not the option is an
incentive stock option or non-qualified option.

      In general, a Participant will not recognize any income upon the exercise
of an incentive stock option, and the Company will not be entitled to a tax
deduction or account of such exercise. However, a Participant could be subject
to the alternative minimum tax upon exercise. If the Code requirements relating
to the holding periods for stock acquired on exercise of an incentive stock
option have been satisfied, a Participant who acquires Company Common Stock upon
the exercise of his or her incentive stock option will recognize any gain or
loss realized upon the sale of such stock as long-term capital gain or loss, but
the Company will not be entitled to any tax deduction on account of such sale.
If such holding period requirements are not satisfied with respect to such stock
acquired on exercise of an incentive stock option, the sale of the stock so
acquired will result in ordinary income being recognized by the Participant in
an amount equal to the excess, with certain adjustments, of the fair market
value

                                       13

<PAGE>

of the underlying stock on the date of exercise over the option price and the
Company will be entitled to a tax deduction in the same amount. Any additional
gain realized by such Participant on such a sale of his or her stock will be
capital gain. If the total amount realized upon such a sale is less than the
exercise price of the incentive stock option, the difference will be a capital
loss to such Participant.

      In the case of a non-qualified option, a Participant generally will
recognize ordinary income upon the exercise of such option in the amount equal
to the excess of the fair market value of the underlying stock on the date of
exercise over the option price, and the Company will be entitled to a tax
deduction in the same amount. Such participant will recognize as capital gain or
loss any profit or loss realized on the sale or exchange of any such shares
disposed of or sold.

      The granting of SARs generally does not produce taxable income under the
Code to the Participant or a tax deduction to the Company. Upon exercise of a
SAR, the amount of any cash the Participant receives and the fair market value
as of the exercise date of any stock received are generally taxable to the
participant as ordinary income and are deductible by the Company.

      A Participant generally will not recognize any income for federal income
tax purposes upon the award of restricted stock which is not transferable and is
subject to a substantial risk of forfeiture. Dividends paid with respect to
restricted stock prior to the lapse of restrictions applicable to such stock
will be taxable as compensation income to the employee. Generally, a Participant
will recognize compensation income at the first time such stock becomes
transferable or no longer subject to a substantial risk of forfeiture, in an
amount equal to the fair market value of such shares of the Company's Common
Stock on the date the restrictions lapse. However, a Participant may elect to
recognize compensation income upon the grant of restricted stock based on the
fair market value of the shares of Common Stock of the Company subject to such
award on the date of such award. If a Participant makes such an election,
dividends paid with respect to such restricted shares will not be treated as
compensation, but rather as dividend income, and the Participant will not
recognize additional income when the restrictions applicable to such restricted
stock lapse. Assuming compliance with the applicable withholding requirements,
the Company will be entitled to a tax deduction equal to the amount of ordinary
income recognized by a Participant in connection with his or her restricted
stock award in the Company's taxable year in which such Participant recognizes
such income.

      The payment of performance grants or other awards under the 1994 Plan in
the form of Common Stock is generally immediately taxable to the Participant and
deductible by the Company; however, to the extent that such stock is not
transferable and subject to a substantial risk of forfeiture, the tax
consequences to the Participant and the Company will be similar to the tax
consequences of awards of restricted stock as described above.

      Under Section 162(m) of the Code, the Company may be limited as to federal
income tax deductions to the extent that total annual compensation in excess of
$1 million is paid to the chief executive officer of the Company or any one of
the other four highest paid executive officers employed by the Company on the
last day of the taxable year. However, certain "performance-based compensation,"
the material terms of which are disclosed to and approved by the Company's
stockholders, is not subject to this limitation on deductibility. The
Corporation has structured the stock option and SAR portions of the 1994 Plan
with the intention that compensation resulting therefrom would be qualified
performance-based compensation and would be deductible without regard to the
limitations otherwise imposed by Section 162(m) of the Code. The 1994 Plan
allows the Committee discretion to award restricted stock and other stock- based
awards that are intended to be qualified performance-based compensation. Bonuses
and other compensation payable in stock under the 1994 Plan are not intended to
qualify as performance-based compensation.


COMPLIANCE WITH SECTION 16(A) OF THE SECURITIES EXCHANGE ACT OF 1934

      Under Section 16(a) of the Securities Exchange Act of 1934, the Company's
directors and certain of its officers, and persons holding more than ten percent
of the Company's Common Stock are

                                       14

<PAGE>

required to file forms reporting their beneficial ownership of the Company's
Common Stock and subsequent changes in that ownership with the Securities and
Exchange Commission. Such persons are also required to furnish the Company
copies of forms so filed. Based solely upon a review of copies of such forms
filed with the Company, each of Drs. Ainsworth, Pilia and Helson were late in
filing one Form 4, on which each such officer reported one transaction, and no
other directors or officers were late in filing any reports on Forms 3, 4 and 5.


COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

      No executive officer of the Company serves or served on the compensation 
committee of another entity during fiscal year 1995 one of whose executive
officers served on the compensation committee of the Company, and no executive
officer of the Company serves or served as a director of another entity who has
or had an executive officer serving on compensation committee of Company, and no
executive officer of the Company serves or served as a member of the
compensation committee of another entity who has or had an executive officer
serving as a director of the Company. Mr. Shaykin, Chairman of the Board of the
Company, was appointed to serve on the Compensation Committee upon its inception
in 1993 and resigned following its first meeting in January 1994. Mr. Shaykin
has been an employee of the Company, and Chairman of the Board of Directors of
the Company since 1993. Effective June 7, 1993, Mr. Shaykin executed a note in
favor of the Company to represent the amount owed for Mr. Shaykin's acquisition
of Executive Stock pursuant to an employment agreement entered into between Mr.
Shaykin and the Company. See " --Certain Relationships and Related
Transactions--Indebtedness of Management." From January 1994 through March 1996,
the Compensation Committee, consisted of Mr. Bewkes, Chairman, and Mr.
Pfenniger. From March 1996 to the present, the Compensation Committee has
consisted of Mr. Bewkes, Chairman, Mr. Bryson, and Mr. Pfenniger. Mr. Pfenniger
served as Chief Operating Officer of IVAX and held various other executive
positions with certain IVAX subsidiaries during 1995. See " --Certain
Relationships and Related Transactions--IVAX."


COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION.

      THE REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS (THE
"COMMITTEE") SHALL NOT BE DEEMED INCORPORATED BY REFERENCE BY ANY GENERAL
STATEMENT INCORPORATING BY REFERENCE THIS REPORT INTO ANY FILING UNDER THE
SECURITIES ACT OF 1933, OR UNDER THE SECURITIES EXCHANGE ACT OF 1934, EXCEPT TO
THE EXTENT THAT THE COMPANY SPECIFICALLY INCORPORATES THIS INFORMATION BY
REFERENCE, AND SHALL NOT OTHERWISE BE DEEMED FILED UNDER SUCH ACTS.

      GOALS. The Committee implements the Company's executive compensation
policies. The Company is committed to executive compensation policies that
promote and support the Company's goals and that inspire executives to make a
significant contribution to the financial performance of the Company. The
Company's overall compensation philosophy for executive officers has the
following objectives: (1) the attraction and retention of qualified personnel
whose participation is important to the short-term and long-term success of the
Company; and (2) the creation of a mutual interest between executive officers
and stockholders that permits executive officers to share in the risks and
rewards of strategic decision-making.

      The Company has established its executive compensation policies using the
above objectives as its foundation. The Committee's current practice is to
review the compensation of: the five highest paid employees of the Company, all
employees earning at least $75,000 per year and any other executive officers of
the Company that are named in any required disclosure documents under applicable
securities laws. The Committee also administers all annual bonuses and equity
based incentive compensation including grants of stock options and restricted
stock. The following describes the three primary components of the Company's
current executive compensation program.

      BASE SALARY. For fiscal year 1995, the base salary compensation of the
Company's Chief Executive Officer, Dr. Ainsworth, and certain other senior
executives, was primarily determined by such officers employment agreements with
the Company. The Compensation Committee believes that the current

                                       15
<PAGE>

base salaries of the Company's executive officers are justified by such
officers' performance and value to the Company, and take into account the market
and competitive conditions affecting the demand for the skills and expertise of
such executive officers.

      ANNUAL BONUS. For fiscal year 1995, the cash bonuses paid to the Company's
executive officers were based primarily on recommendations made to the Committee
by the Chairman of the Board and the President of the Company and the
Committee's own subjective evaluation of the individual executives' performance
and the performance of the Company, taking into account the goals and overall
compensation philosophy stated above.

      EQUITY-BASED INCENTIVES. The Company considers equity-based incentives to
be an integral part of executive compensation. The Committee believes that the
grant of restricted stock awards, stock options and other awards pursuant to the
1993 Stock Option Plan and 1994 Long-Term Performance Incentive Plan has been,
and will continue to be, an effective method for the creation of a mutual
interest between the Company's employees and the Company's stockholders. During
1995, stock options were granted to five executive officers and restricted stock
awards were granted to five executive officers. These grants were recommended to
the Committee by the Chairman of the Board and the President. Factors considered
in the grant of restricted stock awards and stock options generally are the same
as those used in determining annual bonuses. The recommendations of such grants
to the Committee and the Committee's approval of such recommendations were not
based on any specific formulas.


                                            COMPENSATION COMMITTEE

                                            E. Garrett Bewkes, Jr.
                                            Vaughn D. Bryson
                                            Richard C. Pfenniger, Jr
                                       16

<PAGE>

STOCK PRICE PERFORMANCE GRAPH

      THE STOCK PRICE PERFORMANCE GRAPH SHALL NOT BE DEEMED INCORPORATED BY
REFERENCE BY ANY GENERAL STATEMENT INCORPORATING BY REFERENCE THIS REPORT INTO
ANY FILING UNDER THE SECURITIES ACT OF 1933, OR UNDER THE SECURITIES EXCHANGE
ACT OF 1934, EXCEPT TO THE EXTENT THAT THE COMPANY SPECIFICALLY INCORPORATES
THIS INFORMATION BY REFERENCE, AND SHALL NOT OTHERWISE BE DEEMED FILED UNDER
SUCH ACTS.

      The graph below compares the cumulative return of the Company's Common
Stock against the Total Return Index for the Nasdaq Market (U.S.) and a peer
group which is comprised of the companies listed on the Nasdaq Pharmaceutical
Stock Index. The cumulative return presented is based upon an initial investment
of $100 over the period August 1, 1994 through December 29, 1995. The stock
price performance on the graph is not necessarily an indicator of future price
performance. The information presented below was compiled by the Center for
Research in Security Prices at the University of Chicago Graduate School of
Business. The cumulative return of the Company's Common Stock is based upon its
initial public offering price of $5.00 and the last reported sale price of the
Common Stock as reported on the Nasdaq National Market System on December 29,
1995, the last trading day of 1995 ($9.375). The indices assume the 
reinvestment of all dividends.

[GRAPHIC OMITTED]

<TABLE>
<CAPTION>

                                    August 1, 1994      December 30, 1994        December 29, 1995
<S>                                       <C>                  <C>                      <C>
NaPro (NPRO)                             $100                 $120.00                  $187.50
Nasdaq Market (U.S.)                     $100                 $104.38                  $147.63
Peer Group
(Nasdaq Pharmaceutical Index)            $100                 $102.46                  $187.40
</TABLE>

                                       17
<PAGE>

CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

      IVAX

      In June 1993, the Company entered into a 20-year strategic alliance (the
"IVAX Agreement") with Baker Norton Pharmaceuticals, a subsidiary of IVAX, one
of the largest generic pharmaceutical companies in the United States, which
provides for certain exclusive and non-exclusive rights for IVAX to develop and
market the Company's paclitaxel. The Company continues to supply IVAX with
paclitaxel pursuant to the terms of the IVAX Agreement. During 1995, the
Company's sales of paclitaxel to IVAX were $589,660, or 22% of the Company's
revenues during such period and during the first quarter of 1996, the Company's
sales of paclitaxel to IVAX were $204,770, or 30% of the Company's revenues
during such period. IVAX, through D&N, currently beneficially owns 13.2 % of the
Common Stock.

      Pursuant to the IVAX Agreement, IVAX may, under limited circumstances,
obtain manufacturing information from the Company, or, under some circumstances,
terminate its relationship with the Company or purchase paclitaxel from third
parties if the Company is unable to supply paclitaxel in sufficient quantities
to meet IVAX's requirements.

      Phillip Frost and Richard C. Pfenniger, Jr., directors of the Company,
serve, respectively, as Chairman and Chief Executive Officer of IVAX, and Chief
Operating Officer of IVAX, and hold various other executive positions with 
certain IVAX subsidiaries. In addition, the Company has been advised that 
Dr. Frost beneficially owns approximately 11.8% of IVAX's voting securities.

      IVAX (through D&N), Mr. Shaykin, Dr. Ainsworth, Dr. Pilia and the Company
are parties to the Stockholders Agreement pursuant to which, among other things,
each of such directors and IVAX is obligated to vote for the election of Dr.
Ainsworth (as long as he owns beneficially (before taking into consideration any
shares issuable upon exercise or conversion of outstanding options and warrants
or convertible securities, respectively) 5% or more of the outstanding Common
Stock) and two individuals designated by IVAX to the Company's Board of
Directors. These designees currently are Dr. Frost and Mr. Pfenniger.


      INDEBTEDNESS OF MANAGEMENT

      On August 14, 1995, Dr. Ainsworth remitted to the Company 83,907 shares 
of Common Stock in exchange for extinguishment of the debt represented by the
Executive Note of $979,610.91 owed to the Company by Dr. Ainsworth. See
"Proposal 1--Executive Compensation--Employment Agreements and Termination of
Employment Agreements."

      On August 14, 1995, Dr. Pilia remitted to the Company 21,815 shares of 
Common Stock in exchange for extinguishment of the debt represented by the
Executive Note of $254,688.13 owed to the Company by Dr. Pilia. See "Proposal
1--Executive Compensation--Employment Agreements and Termination of Employment
Agreements."

      On August 14, 1995, Dr. Helson remitted to the Company 38,566 shares of 
Common Stock in exchange for extinguishment of the debt represented by the
Executive Note of $450,247.85 owed to the Company by Dr. Helson. See "Proposal
1--Executive Compensation--Employment Agreements and Termination of Employment
Agreements."

      The transactions described above whereby a total of 144,288 shares of
Common Stock were returned to the Company in exchange for extinguishment of debt
were all conducted pursuant to the terms of the Employment and Executive Stock
Agreements, Executive Notes, and Executive Stock Pledge Agreements entered into
by the respective Executives and the Company on June 7, 1993, and subsequently
amended as of May 31, 1994. The stock value computed according to this formula
and used for the purpose of these transactions was $11.675 per share.

                                       18

<PAGE>

         The aggregate outstanding principal of and unpaid interest accrued
under the Executive Note for Mr. Shaykin as of March 31, 1996, was $940,694.

      OTHER

      The Company and MediScience Associates, Inc. ("MediScience"), entered into
a consulting agreement (the "MediScience Agreement") whereby Dr. Hayes, who is
President and Chief Operating Officer of MediScience, will provide the Company
with consulting services in a variety of areas, including clinical research
planning, strategic positioning and regulatory guidance. The Company makes
quarterly payments to MediScience under the MediScience Agreement of $12,500 for
such services. Dr. Hayes is obligated to provide consulting services under the
MediScience Agreement indefinitely, provided that the MediScience Agreement is
terminable by the Company after July 11, 1996 with 90 days prior notice or by
MediScience at any time with 90 days prior notice.

      Vaughn D. Bryson is Vice Chairman of Vector, an investment banking firm
that is the lead managing underwriter of a public offering of the Company for
which a registration statement has been filed with the Securities and Exchange
Commission. Mr. Bryson may also provide consulting services to the Company in
the area of pharmaceutical development in 1996.


    PROPOSAL 2: APPROVAL OF AMENDMENTS TO THE COMPANY'S AMENDED AND RESTATED
                          CERTIFICATE OF INCORPORATION


SUMMARY OF PROPOSED AMENDMENTS

      The Company's Board of Directors has unanimously determined that amending
the Company's Amended and Restated Certificate of Incorporation (the "current
Certificate") in the manner described below is advisable and is in the best
interest of the stockholders and recommends that the Company's stockholders
approve and adopt the proposed amendments. Stockholders are urged to read
carefully the following materials because they involve matters of particular
importance relating to corporate governance.

      The proposed amendments to the current Certificate would (a) classify the
Board of Directors into three classes, with each director, after an interim
realignment period, serving for a term of three years, and with one class being
elected each year; (b) provide that directors may be removed only for cause and
only with the approval of the holders of at least 80% of the voting power of the
Company entitled to vote generally in the election of directors; and (c) require
the concurrence of the holders of at least 80% of the voting power of the
Company entitled to vote generally in the election of directors to alter, amend
or repeal, or to adopt any provision inconsistent with, the foregoing
amendments. The Board also has unanimously approved certain amendments to the
Company's Bylaws to implement, and conform the Bylaws to, the above amendments
to the current Certificate (the "Conforming Bylaw Amendments"). If the proposed
amendments to the current Certificate are approved, the Conforming Bylaw
Amendments will become effective at the same time as the proposed amendments to
the current Certificate.

      As more fully discussed below, the Board of Directors believes these
proposed amendments will help assure the continuity and stability of the
Company's business and affairs. In addition, the Board of Directors believes
that these amendments will assist in providing the Board with sufficient time to
review any unsolicited proposal for an extraordinary corporate transaction (such
as a merger or liquidation) and to consider appropriate alternatives. The
proposed amendments, if adopted by the stockholders, will not impede a takeover
or other transaction that is approved by the directors of the Company. The
proposed amendments will, however, have the overall effect of making it more
difficult and time-consuming to acquire and exercise control of the Company and
to remove incumbent directors, and to benefit from certain transactions which
are opposed by the incumbent Board of Directors.

                                       19
<PAGE>

      THE PROPOSED AMENDMENTS ARE NOT BEING RECOMMENDED IN RESPONSE TO ANY
SPECIFIC EFFORT OF WHICH THE COMPANY IS AWARE TO OBTAIN CONTROL OF THE COMPANY,
BUT RATHER ARE BEING RECOMMENDED IN ORDER TO ASSURE FAIR TREATMENT OF THE
COMPANY'S STOCKHOLDERS. IN ADDITION, WHILE THE COMPANY MAY FROM TIME TO TIME
CONSIDER PROPOSALS WHICH MAY BE CONSIDERED TO HAVE ANTI-TAKEOVER IMPLICATIONS,
THE COMPANY CURRENTLY IS NOT CONSIDERING ANY SUCH PROPOSALS OTHER THAN ADOPTION
OF A RIGHTS PLAN. SEE "CURRENT ANTI-TAKEOVER PROVISIONS--RIGHTS PLAN" BELOW.

      Stockholders are urged to read carefully the following sections of this
Proxy Statement before voting on the proposed amendments to the current
Certificate. The following sections contain a summary of the proposed amendments
and describe their purposes and effects. Appendix A to this Proxy Statement sets
forth the full text of the proposed amendments to the current Certificate. The
description herein of the proposed amendments to the Certificate is qualified in
its entirety by the complete text of such amendments as set forth in Appendix A.


DESCRIPTION OF THE PROPOSED AMENDMENTS

      CLASSIFICATION OF THE BOARD OF DIRECTORS. Directors currently are elected
to the Company's Board of Directors annually for a term of one year. Paragraph
(a) of proposed Article Six of the amended Certificate provides that the Board
shall be divided into three classes of directors, with each class to be as
nearly equal in number of directors as possible. If the proposed amendments are
adopted, the Company's directors will be divided into three classes and three
directors will be elected at the Annual Meeting for a term expiring at the 1997
annual meeting of stockholders, three directors will be elected for a term
expiring at the 1998 annual meeting of stockholders and the remaining three
directors will be elected for a term expiring at the 1999 annual meeting of
stockholders (or, in each case, until their respective successors are duly
elected and qualified). Starting with the 1997 annual meeting of stockholders,
one class of directors will be elected each year for a three-year term. If the
proposed amendments are not adopted, all nine directors will be elected for a
term expiring at the 1997 annual meeting of stockholders or until their
successors are duly elected and qualified.

      Classification of the Board of Directors will have the effect of making it
more difficult to change the composition of the Board of Directors. At least two
stockholder meetings, instead of one, will be required to effect a change in a
majority of the Board. Although in the past the Company has not experienced
problems with the continuity or stability of the Board, the Board believes that,
as a result of the proposed amendments, the longer time required to elect a
majority of a classified Board will help to assure the continuity and stability
of the Company's directors and its policies, since a majority of the directors
at any given time will have prior experience as directors of the Company. A
classified board also will help ensure that the Board, if confronted with an
unsolicited proposal for an extraordinary corporate transaction from a third
party, will have sufficient time to review the proposal and any alternatives.

      REMOVAL OF DIRECTORS. Currently Article III, paragraph 6 of the Bylaws
provides that a director may be removed only for cause, but such paragraph does
not specify the vote required for removal. Proposed Paragraph (c) of Article Six
of the amended Certificate will provide that a director may be removed from
office only for cause, but also will provide specifically that such removal may
only be accomplished by the affirmative vote of the holders of at least 80% of
the voting power of the shares entitled to vote generally in the election of
directors. Under the Delaware General Corporation Law ("DGCL"), unless otherwise
provided in a company's certificate of incorporation, removal of directors
requires only the affirmative vote of a majority of the voting power of the
shares entitled to be voted for the election of directors.

      The proposed amendments relating to the removal of directors will make it
more difficult for a third party to remove incumbent directors than under the
current Certificate and Bylaws. By making removal of directors more difficult,
the Company will be able to prevent persons from circumventing the protections
provided by a classified board through attempts to remove directors. See
"--Certain Anti-Takeover Provisions--Current Certificate and Bylaw Provisions"
below for a discussion on the Board's ability to control the filling of
vacancies on the Board of Directors under the current Bylaws.

                                       20

<PAGE>

      INCREASED STOCKHOLDER VOTE FOR ALTERATION, AMENDMENT OR REPEAL OF PROPOSED
AMENDMENTS. Under the DGCL, amendments to a certificate of incorporation require
the approval of the holders of a majority of the outstanding stock entitled to
vote on the amendment and of a majority of the outstanding stock of each class
entitled to vote on the amendment as a class. The DGCL also permits provisions
in a certificate of incorporation that require a greater vote than the vote
otherwise required by law for any corporate action. With respect to a provision
of a certificate of incorporation that requires a greater than majority vote,
the DGCL requires that any alteration, amendment or repeal thereof be approved
by an equally large stockholder vote. If the proposed Article Nine of the
amended Certificate is approved by the stockholders, alteration, amendment or
repeal of, or the adoption of any provision inconsistent with, the proposed
amendments to the current Certificate discussed above would require the
concurrence of the holders of at least 80% of the voting power of the Company
entitled to vote generally in the election of directors. In addition, under
proposed paragraph (d) of Article Six of the amended Certificate, none of the
Conforming Bylaw Amendments related to the proposed amendments to the current
Certificate, nor may any of the current Bylaw provisions described under
"--Certain Anti-Takeover Provisions--Current Certificate and Bylaw Provisions"
be altered, amended or repealed, nor may any provision inconsistent therewith be
adopted by stockholder action, without the concurrence of the holders of at
least 80% of the voting power of the Company.

      The requirement of an 80% stockholder vote to amend such provisions is
designed to prevent a stockholder with a majority of the voting power of the
Company from eliminating the requirements of the proposed amendments and Article
III, paragraph 2 of the current Bylaws that allows only the Board to determine
the size of the Board, by simply repealing such provisions.

      Stockholders should consider that obtaining a greater than majority vote
can be difficult. The percentage of outstanding shares of Common Stock entitled
to vote held by directors and executive officers as of May 31, 1996, was 32.2%.
See " Security Ownership of Certain Beneficial Owners and Management."


PURPOSE AND POSSIBLE EFFECTS OF THE PROPOSED AMENDMENTS

      The purpose of the proposed amendments to the current Certificate is to
help assure the continuity and stability of the Company's business strategies
and policies and to reduce the vulnerability of the Company to an unsolicited
proposal for the takeover of the Company or for the restructuring or sale of all
or part of the Company upon terms that the Board of Directors deems to be 
inadequate.

      The Board of Directors of the Company believes that an imminent threat of
removal of the Company's Board and management in the face of an unsolicited
proposal regarding an extraordinary corporate transaction would severely curtail
the Company's ability to negotiate effectively with such persons on behalf of
all other stockholders. Management and the Board would be deprived of the time
and information necessary to evaluate the unsolicited proposal and to study
alternatives to ensure that the best price is obtained in any such transaction.
The proposed amendments are designed to make it more time-consuming to change
majority control of the Board and to thus reduce the Company's vulnerability.

      Takeovers or changes in management of the Company that may be proposed and
effected without prior consultation and negotiation with the Company's
management are not necessarily detrimental to the Company and its stockholders.
The proposed amendments will make more difficult or discourage a proxy contest
or the assumption of control by a holder of a substantial block of the Company's
stock or the removal of the incumbent Board and could thus increase the
likelihood that incumbent directors will retain their positions. The proposed
amendments, if adopted, could also have the effect of discouraging such actions,
even though stockholders may feel that such an attempt would be beneficial to
them or the Company. In addition, since the proposed amendments may discourage
tender offers, open market purchases in anticipation of tender offers, and other
investment and speculative market activity that may have the effect of
increasing the market price of or price volatility in the Company's stock,
stockholders could be deprived of certain opportunities to sell their stock at a
higher prices resulting from market volatility caused by such events.

                                       21
<PAGE>

      The Board of Directors, however, believes that the benefits of seeking to
protect its ability to negotiate with the proponent of an unfriendly or
unsolicited proposal to takeover or restructure the Company outweigh the
disadvantages of potentially discouraging such proposals. The proposed
amendments are intended to encourage persons seeking to acquire control of the
Company to initiate such an acquisition through arm's-length negotiations with
the Company's management and Board of Directors who would then be in a position
to negotiate a transaction that is fair to all stockholders.


CURRENT ANTI-TAKEOVER PROVISIONS

      If adopted, the proposed amendments may have the effect of making it more
difficult for stockholders to take certain actions without support of the Board
of Directors even though holders of a majority of the voting power the 
Company may be in favor of such action. These factors should be considered
together with certain other features of the Company's current Certificate,
Bylaws and the DGCL that also may have anti-takeover effects. In addition, the
Company is considering adoption of a "rights plan" as described below.

      PREFERRED STOCK. The current Certificate authorizes the issuance of shares
of Preferred Stock of the Company by action of the Board of Directors without
further action by the stockholders. Thus, the Board of Directors could authorize
the issuance of shares of the Preferred Stock with special voting and other
rights which could deter, or hinder the completion of, any proposed tender
offer, merger or other attempt to gain control of the Company which is not
approved by the Board of Directors, to the extent permissible under applicable
law. Issuance of such Preferred Stock could make removal of incumbent management
more difficult, even if such removal were viewed as in the best interests of
stockholders of the Company, for example, in circumstances in which a block of
newly issued preferred shares were to be placed with a stockholder supporting
present management or who enters into a voting agreement with respect to the
preferred shares. The Company has no commitments, agreements or plans with
respect to such issuances of any shares of Preferred Stock.

      CURRENT CERTIFICATE AND BYLAW PROVISIONS. The current Certificate and
Bylaws contain certain provisions that may have the effect of making it more
difficult for stockholders to take certain actions without support of the Board
of Directors even though holders of a majority of the voting power the Company
may be in favor of such action. Under the current Certificate and Bylaws, the
Board of Directors has the power to determine the number of directors. In
addition, under the current Bylaws, subject to the rights that may be granted to
any holders of Preferred Stock, vacancies and newly created directorships
resulting from any increase in the authorized number of directors are filled
solely by the majority vote of the directors then in office, though less than a
quorum or by a sole remaining director. Also, the current Bylaws require that
nominations by stockholders for persons to be elected to the Board comply with
strict nomination procedures that include specified advance notice to the
Company of any such nomination and requirements to provide detailed information
concerning any nominee and the nominating stockholder. In addition, the current
Certificate specifically prohibits any stockholder action by written consent.

      RIGHTS PLAN. The Company is considering adoption of a rights plan (the
"Rights Plan"), which would not require stockholder approval. The Rights Plan
would have both a "flip-in" and "flip-over" provision. For the "flip-in"
provision, existing stockholders as of a record date would be issued a right to
purchase a fractional share of a new series of preferred stock at a purchase
price as yet to be determined for each share of Common Stock held. The structure
of the new series of preferred stock would be such that each such fractional
share of preferred stock would be equivalent in voting and economic rights to
one share of Common Stock. The rights initially would not be exercisable and
would not be separately transferable from the Common Stock. The rights would
become exercisable only if a person or group acquires beneficial ownership of a
specified percentage (the "Threshold Percentage") of the outstanding Common
Stock. In that event, all holders of the rights other than the person or group
who acquired the Threshold Percentage would be allowed to purchase shares of
Common Stock with a market value price. This right would be triggered a
specified number of days following the passing of the Threshold Percentage. For
the "flip-over" provision, if the Company was acquired after

                                       22

<PAGE>

the Threshold Percentage is passed in such a manner that the Company is not the
surviving entity, the acquiring entity would be required to allow the Company's
stockholders to be issued stock in the acquiring company for one-half of the
then current market price.

      The Board of Directors would be able to redeem the rights for a nominal
price per right at any time until the "flip- in" provision is triggered by a
person or group of persons passing the Threshold Percentage. Redemption after
the Threshold Percentage is passed would require the approval of the Board of
Directors that are unrelated to the stockholder who passed the Threshold
Percentage. The Board of Directors would be able to amend the terms of the
Rights Plan at any time, except that certain basic terms such as the exercise
price could not be amended.

      TRANSACTIONS WITH AN INTERESTED STOCKHOLDER. Section 203 of the DGCL
regulates certain transactions, including mergers, other business combinations
and similar transactions between the Company and an "interested stockholder"
("owners" of 15% or more of the Company's outstanding voting stock, for purposes
of this provision of the DGCL) and may have the effect of discouraging a
non-negotiated bid or proposal to acquire the Company. While not preventing
acquisition of control of the Company by third parties, Section 203 may inhibit
the ability to exercise such control and delay or make such transactions more
difficult except when such acquisition of control is approved in advance by the
board of directors (provided that the restrictions of Section 203 do not apply
if the "interested stockholder" will own at least 85% of a corporation's
outstanding voting stock, excluding certain shares, upon consummation of the
transaction that results in such person becoming an "interested stockholder").
Section 203 is designed to permit an acquirer to make a fairly-priced tender
offer for all of a corporation's shares, since an offeror who can obtain an
ownership level of 85% of the corporation's voting stock in the same transaction
that takes it over 15% is not restricted by the statute. However, as of May 31,
1996, the directors and officers of the Company as a group held 32.2% of the
outstanding Common Stock; therefore, it is highly unlikely that an acquirer
would be able to reach such 85% ownership level, and any potential acquirer
would be left with a negotiated transaction as its only practical alternative.


VOTE REQUIRED FOR APPROVAL OF PROPOSED AMENDMENTS

      Under the DGCL, the affirmative vote of the holders of a majority of the
shares of stock of the Company entitled to notice of and to vote at the Annual
Meeting is required to approve and adopt the proposed amendments to the current
Certificate. The Conforming Bylaw amendments have been approved by the Board and
none of such amendments require shareholder approval. The Conforming Bylaw
Amendments will become effective only upon the effectiveness of the amendments
to the current Certificate.

MANAGEMENT AND THE BOARD OF DIRECTORS RECOMMEND A VOTE FOR APPROVAL OF THE
PROPOSED AMENDMENTS TO THE CURRENT CERTIFICATE.


     PROPOSAL 3: AMENDMENTS TO THE 1994 LONG-TERM PERFORMANCE INCENTIVE PLAN

DESCRIPTION OF PROPOSED AMENDMENTS

      Contingent upon approval by the stockholders, the Board of Directors has
adopted amendments to the 1994 Plan to: (i) increase the maximum number of
shares of Common Stock issuable as awards under the 1994 Plan from 375,000 to
875,000 (of which 180,000 shares will be reserved for issuance to non-employee
directors under the formula provisions of the 1994 Plan); (ii) provide that the
maximum number of underlying shares of Common Stock that any participant may be
granted under awards under the 1994 Plan in any one taxable year will be 200,000
shares; (iii) increase the number of shares of Common Stock underlying automatic
grants of non-qualified stock options to non-employee directors

                                       23

<PAGE>

from 5,000 to 10,000 shares ; (iv) provide for automatic grants of non-qualified
stock options to purchase 10,000 shares of Common Stock to each director who
serves as chairman of the Audit, Compensation and Strategic Planning Committees
of the Board of Directors; (v) provide for a period of 90 days following
termination of an employee's relationship with the Company, or for a period of
three years in the case of a resignation or removal of a non-employee director,
during which vested stock options granted under the 1994 Plan will remain
exercisable, unless an employee or a non-employee director, as the case may be,
is terminated or removed for cause; and (vi) provide that plan participants who
resume employment or performance of services for the Company after termination
by reason of disability may exercise unvested stock options in accordance with a
revised vesting schedule and that the expiration date of such stock options
(other than incentive stock options) be automatically extended by the length of
time such participant remained terminated by reason of disability. The full text
of the 1994 Plan as proposed to be amended is set forth in Appendix B to this
Proxy Statement and the description contained herein is qualified in its
entirety by Appendix B.

      A description of the 1994 Plan is included under the heading "1994
Long-Term Performance Incentive Plan" under Proposal 1.

      Adoption of these amendments requires the approval of holders of a
majority of the voting power of the outstanding shares of Common Stock and
Preferred Stock represented at the Annual Meeting.


REASONS FOR PROPOSED AMENDMENTS
      As of the date of this Proxy Statement, stock options have been granted
under the 1994 Plan to purchase a total of 315,828 shares, leaving only 59,172
shares of Common Stock available for grants under the 1994 Plan. The Board
believes that it is in the best interest of the Company to increase the number
of shares available for awards under the 1994 Plan, and to increase the maximum
number of shares that may be awarded each taxable year, in order to allow the
Company to grant awards to attract and retain new employees and to further
compensate, where appropriate, employees who previously have been awarded, or
who previously have not been awarded, options under the 1994 Plan. The Proposed
amendment to establish 200,000 shares as the maximum number of shares that may
be awarded each taxable year clarifies the Board's intention that there should
not be any limitation in any given taxable year as to the number of shares
underlying Awards that may be exercised in any given taxable year other than as
specified in any vesting provisions of a particular Award. The Board also
believes that it is in the best interest of the Company to increase the number
of shares subject to annual grants of stock options to non-employee directors
and committee chairman in order to provide such directors with additional
incentives to improve the Company's long-term performance and to provide
benefits to such directors that are commensurate with the services provided by
such directors to the Company. Finally, the Board of Directors has determined
that providing for a period of time in which to exercise stock options following
termination of employment or resignation or removal of a non-employee director
is in the best interest of the Company because such provisions will provide the
participants in the 1994 Plan added value and flexibility and will make the
provisions of the 1994 Plan more similar to typical provisions found in
executive compensation plans of public companies, unless an employee or a
non-employee director, as the case may be, is removed for cause.

      The Board believes that participants in the plan whose employment or
performance of services for the Company is terminated by reason of disability
who thereafter resume such employment or performance of services should not be
penalized for such period of disability. The Board therefore adopted the
proposed amendment to the 1994 Plan to allow a continuation of the vesting of
unexercised shares underlying stock options in such circumstances. The Board
also believes that in such circumstances the expiration date of the stock option
should be extended to account for the time of such disability during which the
vesting of shares under the option was discontinued. This amendment will not
apply to any incentive stock options which by their terms may not have a term of
more than ten years from the date of grant.

                                       24
<PAGE>

NEW PLAN BENEFITS

      On October 16, 1995, the Compensation Committee granted to Leonard P.
Shaykin a stock option to purchase 50,000 shares of Common Stock, subject to
stockholder approval at the Annual Meeting of the proposed amendments to the
1994 Plan, at an exercise price of $10.125 per share. In addition, if such 
amendments are approved, each of the non-employee directors, Messrs. Bewkes,
Pfenniger, Frost, Hayes, Hacken, and Bryson will be granted stock options to
purchase 10,000 shares of Common Stock and Messrs. Bewkes, Hacken and Bryson, as
the respective chairs of the Audit, Compensation and Strategic Planning
Committees, each will be granted options to purchase an additional 10,000
shares. The exercise price of such stock options will be the fair market value
of the Common Stock on the next business day following the Annual Meeting if the
proposed amendments to the 1994 Plan are approved. None of such stock options
have any force or effect or become exercisable unless the amendments to the 1994
Plan are approved by the stockholders. Mr. Shaykin and all such non-employee
directors have been nominated for re-election to the Board of Directors at the
Annual Meeting. The following table sets forth the number of stock options to be
granted to each such director and the non-executive directors as a group.

                                NEW PLAN BENEFITS
      NAPRO BIOTHERAPEUTICS, INC. 1994 LONG-TERM PERFORMANCE INCENTIVE PLAN

           NAME AND POSITION                    NUMBER OF STOCK OPTIONS
           -----------------                    -----------------------
     Leonard P. Shaykin(1)                            50,000
     E. Garrett Bewkes, Jr. (2)(3)                    20,000
     Richard C. Pfenniger, Jr.(2)                     10,000
     Phillip Frost(2)                                 10,000
     Arthur H. Hayes, Jr.(2)                          10,000
     Mark B. Hacken(2)(4)                             20,000
     Vaughn D. Bryson(2)(5)                           20,000
     Executive Group                                  50,000
     Non-Executive Director Group                     90,000
     Non-Executive Officer                                 --
     Employee Group
                  ----------
                  (1)  Chairman of the Board of Directors
                  (2)  Director
                  (3)  Chairman of Compensation Committee
                  (4)  Chairman of Audit Committee
                  (5)  Chairman of Strategic Planning Committee

                  THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THIS PROPOSAL TO
APPROVE THE AMENDMENTS TO THE 1994 LONG-TERM PERFORMANCE INCENTIVE PLAN.
  

          PROPOSAL 4: RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS


RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS

         The Board of Directors has selected Ernst & Young LLP as the Company's
independent auditors for the year ending December 31, 1996, and has further
directed that management submit this selection of independent auditors for
ratification by the stockholders at the Annual Meeting. Ernst & Young LLP have
audited the Company's financial statements for 1995. Representatives of Ernst &
Young LLP who are expected to be present at the Annual Meeting will have an
opportunity to make a statement if they desire to do so and will be available to
respond to appropriate questions. If a majority of the shares voted at the
Annual Meeting do not vote for ratification of the selection of Ernst & Young
LLP, the Board of Directors will reconsider such selection.

                                       25
<PAGE>

      MANAGEMENT AND THE BOARD OF DIRECTORS RECOMMEND A VOTE FOR THIS PROPOSAL
TO RATIFY SELECTION OF ERNST & YOUNG LLP AS THE COMPANY'S INDEPENDENT AUDITORS.


                                  OTHER MATTERS

         The Board of Directors knows of no other business to be presented at
the meeting, but if other matters do properly come before the meeting, it is
intended that the persons named in the proxy will vote in respect thereof in
accordance with their best judgment.

         The Board of Directors encourages you to have your shares voted by
signing and returning the enclosed proxy. The fact that you will have returned
your proxy in advance will not affect your right to vote in person should you
find it possible to attend. However, by signing and returning the proxy, you
have assured your representation at the Annual Meeting. Thank you for your
cooperation.

                                       By Order of the Board of Directors,




                                       Patricia A. Pilia
                                       Secretary

Boulder, Colorado
July 12, 1996
                                       26
<PAGE>

                                                                    APPENDIX A

                           PROPOSED AMENDMENTS TO THE

                AMENDED AND RESTATED CERTIFICATE OF INCORPORATION
                                       OF

                           NAPRO BIOTHERAPEUTICS, INC.


ARTICLE SIX WILL BE AMENDED IN ITS ENTIRETY AS FOLLOWS (MARKED TO SHOW CHANGES):

                                   ARTICLE SIX

     The following provisions are inserted for the management of the business
and the conduct of the affairs of the Corporation, and for further definition,
limitation and regulation of the powers of the Corporation and of its directors
and stockholders:

     (a) The business and affairs of the Corporation shall be managed by or
under the direction of the Board of Directors. THE BOARD OF DIRECTORS SHALL BE
DIVIDED INTO THREE CLASSES, DESIGNATED AS CLASS I, CLASS II AND CLASS III. EACH
CLASS SHALL CONSIST, AS NEARLY AS MAY BE POSSIBLE, OF ONE-THIRD OF THE TOTAL
NUMBER OF DIRECTORS CONSTITUTING THE ENTIRE BOARD OF DIRECTORS. AT THE 1996
ANNUAL MEETING OF STOCKHOLDERS, CLASS I DIRECTORS SHALL BE ELECTED FOR A
ONE-YEAR TERM, CLASS II DIRECTORS FOR A TWO-YEAR TERM AND CLASS III DIRECTORS
FOR A THREE YEAR TERM. AT EACH SUCCEEDING ANNUAL MEETING OF STOCKHOLDERS
BEGINNING IN 1997, SUCCESSORS TO THE CLASS OF DIRECTORS WHOSE TERM EXPIRES AT
SUCH ANNUAL MEETING SHALL BE ELECTED TO A THREE-YEAR TERM. IF THE NUMBER OF
DIRECTORS IS CHANGED, ANY INCREASE OR DECREASE SHALL BE APPORTIONED AMONG THE
CLASSES SO AS TO MAINTAIN THE NUMBER OF DIRECTORS IN EACH CLASS AS NEARLY EQUAL
AS POSSIBLE, AND ANY ADDITIONAL DIRECTOR OF ANY CLASS WHO IS ELECTED TO FILL A
VACANCY RESULTING FROM AN INCREASE IN SUCH CLASS SHALL HOLD OFFICE FOR A TERM
THAT SHALL COINCIDE WITH THE REMAINING TERM OF SUCH CLASS, BUT IN NO CASE WILL A
DECREASE IN THE NUMBER OF DIRECTORS SHORTEN THE TERM OF ANY INCUMBENT DIRECTOR.

     (b) Except for any directors who may be elected under specified
circumstances set forth in a Preferred Stock Designation by the holders, if any,
of any class or series of Preferred Stock then existing, the exact number of
directors of the Corporation shall be determined from time to time by resolution
of the Board of Directors.

     (c) EXCEPT AS MAY BE OTHERWISE PROVIDED PURSUANT TO PART II OF ARTICLE 
FOUR OF THE CERTIFICATE OF INCORPORATION OF THE CORPORATION IN CONNECTION WITH
RIGHTS TO ELECT ADDITIONAL DIRECTORS UNDER SPECIFIED CIRCUMSTANCES WHICH MAY BE
GRANTED TO THE HOLDERS OF ANY CLASS OR SERIES OF PREFERRED STOCK, ANY DIRECTOR
OR THE ENTIRE BOARD OF DIRECTORS MAY BE REMOVED ONLY FOR CAUSE BY THE
AFFIRMATIVE VOTE OF THE HOLDERS OF AT LEAST 80% OF THE VOTING POWER OF ALL OF
THE CAPITAL STOCK OF THE CORPORATION ENTITLED TO VOTE GENERALLY IN THE ELECTION
OF DIRECTORS, VOTING TOGETHER AS A SINGLE CLASS.

     (D) The Board of Directors is expressly authorized to make, alter, amend,
change, add to or repeal the Bylaws of the Corporation. NOTWITHSTANDING 
ANYTHING CONTAINED IN THIS CERTIFICATE OF INCORPORATION OR BYLAWS OF THE
CORPORATION TO THE CONTRARY, THE STOCKHOLDERS OF THE CORPORATION, AT A DULY
CALLED ANNUAL OR SPECIAL MEETING OF STOCKHOLDERS, MAY NOT TAKE ANY ACTION TO
ALTER, AMEND, REPEAL OR ADOPT ANY PROVISION INCONSISTENT WITH PARAGRAPHS 2, 3, 4
AND 6 OF THE BYLAWS OF THE CORPORATION WITHOUT THE AFFIRMATIVE VOTE OF THE
HOLDERS OF AT LEAST 80% OF THE VOTING POWER OF ALL OF THE CAPITAL STOCK OF THE
CORPORATION ENTITLED TO VOTE GENERALLY IN THE ELECTION OF DIRECTORS, VOTING
TOGETHER AS A SINGLE CLASS.

     (E) The Corporation shall indemnify, to the fullest extent permitted
by Section 145 of the General Corporation Law of the State of Delaware, as
amended from time to time, all persons whom it may indemnify pursuant thereto.
The personal liability of a director or officer of the Corporation to the
Corporation or its stockholders for monetary damages for breach of fiduciary
duty as a director or officer shall be limited to the fullest extent permitted
by the General Corporation Law of the State of Delaware, as it now exists or may
hereafter be amended. Any repeal or modification of this paragraph by the
stockholders of the Corporation shall not adversely affect any right or
protection of a director or officer of the Corporation existing at the time of
such repeal or modification.
<PAGE>

     (F) In addition to the power and authority hereinbefore or by statute
expressly conferred upon them, the directors are hereby empowered to exercise
all such powers and do all such acts and things as may be exercised or done by
the Corporation, subject, nevertheless, to the provisions of the General
Corporation Law of the State of Delaware, this Certificate of Incorporation and
any Bylaws adopted by the stockholders; provided, however, that no Bylaws
hereafter adopted by the stockholders shall invalidate any prior act of the
directors which would have been valid if such Bylaws had not been adopted.

     (G) Notwithstanding Section 228(a) of the General Corporation Law of the
State of Delaware, no action shall be taken by the stockholders of the
Corporation by written consent in lieu of any annual or special meeting of the
stockholders.


          A NEW ARTICLE NINE WILL BE ADDED IN ITS ENTIRETY AS FOLLOWS:

                                  ARTICLE NINE

         Notwithstanding anything contained in this Certificate of Incorporation
to the contrary, Article Six hereof shall not be altered, amended or repealed
and no provision inconsistent therewith shall be adopted without the affirmative
vote of the holders of at least 80% of the voting power of all of the capital
stock of the Corporation entitled to vote generally in the election of
directors, voting together as a single class. Notwithstanding anything contained
in this Certificate of Incorporation to the contrary, the affirmative vote of
the holders of at least 80% of the voting power of all of the capital stock of
the Corporation entitled to vote generally in the election of directors, voting
together as a single class, shall be required to alter, amend, repeal or adopt
any provision inconsistent with this Article Nine.

                                  Appendix A-2
<PAGE>
                                                                   APPENDIX B


                           NAPRO BIOTHERAPEUTICS, INC.
                    1994 LONG-TERM PERFORMANCE INCENTIVE PLAN


         1. PURPOSE. The purpose of the 1994 Long-Term Performance Incentive
Plan of NaPro BioTherapeutics, Inc. (the "Plan") is to advance the interests of
NaPro BioTherapeutics, Inc., a Delaware corporation (the "Company"), and its
stockholders by providing incentives to certain employees of the Company and to
certain other key individuals who perform services for the Company, including
those who contribute significantly to the strategic and long-term performance
objectives and growth of the Company. In the case of options granted to the
Company's non-employee directors, the Plan is intended to more closely align the
interests of such directors with the Company's stockholders.

         2. ADMINISTRATION. The Plan shall be administered solely by the Board
of Directors (the "Board") of the Company or, if the Board shall so designate,
by a committee of the Board that shall be comprised of not fewer than two
directors (the "Committee"); provided that if at any time Rule 16b-3 or any
successor rule ("Rule 16b-3") under the Securities Exchange Act of 1934, as
amended (the "Exchange Act"), and Section 162(m) of the Internal Revenue Code of
1986, as amended, or any successor statutory provision thereto (the "Code"), and
any implementing regulations (and any successor provisions thereof), so permit
without adversely affecting the ability of the Plan to comply with the
conditions for exemption from Section 16 of the Exchange Act (or any successor
provision) provided by Rule 16b-3 and the exemption from the limitations on the
deductibility of certain executive compensation provided by Section 162(m), the
Committee may delegate the administration of the Plan in whole or in part, on
such terms and conditions, to such other person or persons as it may determine
in its discretion. References to the Committee hereunder shall include the Board
where appropriate. The membership of the Committee or such successor committee
shall be constituted so as to comply at all times with the applicable
requirements of Rule 16b-3 and Section 162(m). No member of the Committee shall
have within one year prior to his appointment received awards under the Plan
("Awards") or under any other plan, program or arrangement of the Company or any
of its affiliates if such receipt would cause such member to cease to be a
"disinterested person" under Rule 16b-3; provided that if at any time Rule 16b-3
so permits without adversely affecting the ability of the Plan to comply with
the conditions for exemption from Section 16 of the Exchange Act (or any
successor provision) provided by Rule 16b-3, one or more members of the
Committee may cease to be a "disinterested person."

         The Committee has all the powers vested in it by the terms of the Plan
set forth herein, such powers to include exclusive authority (except as may be
delegated as permitted herein) (i) to select the employees and other key
individuals to be granted Awards under the Plan, (ii) to determine the type,
size and terms of the Award to be made to each individual selected, subject to
the limitations set forth in Paragraph 4(b), (iii) to modify the terms of any
Award that has been granted, (iv) to determine the time when Awards will be
granted, (v) to establish performance objectives, (vi) to make any adjustments
necessary or desirable as a result of the granting of Awards to eligible
individuals located outside the United States and (vii) to prescribe the form of
the instruments embodying Awards made under the Plan; provided, however, that
the terms of the formula plan set forth in Paragraph 9 shall not be subject to
the discretion of the Committee. The Committee is authorized (A) to interpret
the Plan and the Awards granted under the Plan, (B) to establish, amend and
rescind any rules and regulations relating to the Plan, and (C) to make any
other determinations which it deems necessary or desirable for the
administration of the Plan. The Committee (or its delegate as permitted herein)
may correct any defect or supply any omission or reconcile any inconsistency in
the Plan or in any Award in the manner and to the extent the Committee deems
necessary or desirable to carry it into effect. Any decision of the Committee
(or its delegate as permitted herein) in the interpretation and administration
of the Plan, as described herein, shall lie within its sole and absolute
discretion and shall be final, conclusive and binding on all parties concerned.
The Committee may act only by a majority of its members in office, except that
the members thereof may authorize any one or more of their members or any
officer of the Company to execute and deliver documents or to take any other
ministerial action on behalf of the Committee with respect to Awards made or to
be made to Plan participants. No member of the Committee and no officer of the
Company shall be liable for anything done or omitted to be done by him, by any
other member of the Committee or by any officer of the Company in connection
with the performance of duties under the Plan, except for his own willful
misconduct or as expressly provided by statute. Determinations to be made by the
Committee under the Plan may be made by its delegates as permitted herein.

         3. ELIGIBILITY. Consistent with the purposes of the Plan, the Committee
shall have exclusive power (except as may be delegated as permitted herein) to
select the key employees and other key individuals performing services for the
Company and any of its subsidiaries who may participate in the Plan and be
granted Awards under the Plan. Eligible

                                 Appendix B - 1

<PAGE>

individuals may be selected individually or by groups or categories, as
determined by the Committee in its discretion. No non-employee director of the
Company shall be eligible to receive an Award under the Plan, except pursuant to
the formula plan set forth in Paragraph 9.

         4.       AWARDS UNDER THE PLAN.

         (a) TYPES OF AWARDS. Awards under the Plan may include, but need not be
limited to, one or more of the following types, either alone or in any
combination thereof: (i) "Stock Options," (ii) "Stock Appreciation Rights,"
(iii) "Restricted Stock," (iv) "Performance Grants" and (v) any other type of
Award deemed by the Committee in its discretion to be consistent with the
purposes of the Plan (including, but not limited to, Awards of or options or
similar rights granted with respect to unbundled stock units or components
thereof, and Awards to be made to participants who are foreign nationals or are
employed or performing services outside the United States). Stock Options, which
include "Nonqualified Stock Options" (which may be awarded to participants or
sold at a price determined by the Committee ("Purchased Options")) and
"Incentive Stock Options" or combinations thereof, are rights to purchase common
shares of the Company having a par value of $.0075 per share and stock of any
other class into which such shares may thereafter be changed (the "Common
Shares"). Nonqualified Stock Options and Incentive Stock Options are subject to
the terms, conditions and restrictions specified in Paragraph 5. Stock
Appreciation Rights are rights to receive (without payment to the Company) cash,
Common Shares, other Company securities (which may include, but need not be
limited to, unbundled stock units or components thereof, debentures, preferred
stock, warrants, securities convertible into Common Shares or other property
("Other Company Securities")) or property, or other forms of payment, or any
combination thereof, as determined by the Committee, based on the increase in
the value of the number of Common Shares specified in the Stock Appreciation
Right. Stock Appreciation Rights are subject to the terms, conditions and
restrictions specified in Paragraph 6. Shares of Restricted Stock are Common
Shares which are issued subject to certain restrictions pursuant to Paragraph 7.
Performance Grants are contingent awards subject to the terms, conditions and
restrictions described in Paragraph 8, pursuant to which the participant may
become entitled to receive cash, Common Shares, Other Company Securities or
property, or other forms of payment, or any combination thereof, as determined
by the Committee.

         (b) MAXIMUM NUMBER OF SHARES THAT MAY BE ISSUED. There may be issued
under the Plan (as Restricted Stock, in payment of Performance Grants, pursuant
to the exercise of Stock Options or Stock Appreciation Rights, or in payment of
or pursuant to the exercise of such other Awards as the Committee, in its
discretion, may determine) an aggregate of not more than (deleted text 375,000)
875,000 Common Shares subject to adjustment as provided in Paragraph 15, of
which (deleted text 75,000) 180,000 shall be available for grant pursuant to the
formula plan set forth in Paragraph 9. The maximum number of UNDERLYING Common
Shares which any participant may (deleted text acquire pursuant to a grant of)
BE GRANTED UNDER Stock Options, Stock Appreciation Rights, Restricted Stock,
Performance Grants or any other Award in any one taxable year of the Company
shall not exceed (deleted text 50,000)200,000 Common Shares. Common Shares
issued pursuant to the Plan may be either authorized but unissued shares,
treasury shares, reacquired shares, or any combination thereof. If any Common
Shares issued as Restricted Stock or otherwise subject to repurchase or
forfeiture rights are reacquired by the Company pursuant to such rights, or if
any Award is canceled, terminates or expires unexercised, any Common Shares that
would otherwise have been issuable pursuant thereto will be available for
issuance under new Awards.

         (c)      RIGHTS WITH RESPECT TO COMMON SHARES AND OTHER SECURITIES.

                           (i) Unless otherwise determined by the Committee in
         its discretion, a participant to whom an Award of Restricted Stock has
         been made (and any person succeeding to such a participant's rights
         pursuant to the Plan) shall have, after issuance of a certificate for
         the number of Common Shares awarded and prior to the expiration of the
         Restricted Period (as hereinafter defined), ownership of such Common
         Shares, including the right to vote the same and to receive dividends
         or other distributions made or paid with respect to such Common Shares
         (provided that such Common Shares, and any new, additional or different
         shares, or Other Company Securities or property, or other forms of
         consideration which the participant may be entitled to receive with
         respect to such Common Shares as a result of a stock split, stock
         dividend or any other change in the corporation or capital structure of
         the Company, shall be subject to the restrictions hereinafter described
         as determined by the Committee in its discretion), subject, however, to
         the options, restrictions and limitations imposed thereon pursuant to
         the Plan. Notwithstanding the foregoing, a participant with whom an
         Award agreement is made to issue Common Shares in the future, shall
         have no rights as a stockholder with respect to Common Shares related
         to such agreement until issuance of a certificate to him.

                                 Appendix B - 2

<PAGE>

                           (ii) Unless otherwise determined by the Committee in
         its discretion, a participant to whom a grant of Stock Options, Stock
         Appreciation Rights, Performance Grants or any other Award is made (and
         any person succeeding to such a participant's rights pursuant to the
         Plan) shall have no rights as a stockholder with respect to any Common
         Shares or as a holder with respect to other securities, if any,
         issuable pursuant to any such Award until the date of the issuance of a
         stock certificate to him for such Common Shares or other instrument of
         ownership, if any. Except as provided in Paragraph 15, no adjustment
         shall be made for dividends, distributions or other rights (whether
         ordinary or extraordinary, and whether in cash, securities, other
         property or other forms of consideration, or any combination thereof)
         for which the record date is prior to the date such stock certificate
         or other instrument of ownership, if any, is issued.

         5. STOCK OPTIONS. The Committee may grant or sell Stock Options either
alone, or in conjunction with Stock Appreciation Rights, Performance Grants or
other Awards, either at the time of grant or by amendment thereafter; provided
that an Incentive Stock Option may be granted only to an eligible employee of
the Company or any parent or subsidiary corporation. Each Stock Option (referred
to herein as an "Option") granted or sold under the Plan shall be evidenced by
an instrument in such form as the Committee shall prescribe from time to time in
accordance with the Plan and shall comply with the following terms and
conditions, and with such other terms and conditions, including, but not limited
to, restrictions upon the Option or the Common Shares issuable upon exercise
thereof, as the Committee, in its discretion, shall establish:

         (a) Subject to the terms of options granted pursuant to the formula
plan set forth in Paragraph 9, the option price may be equal to or greater than
the fair market value of the Common Shares subject to such Option at the time
the Option is granted, as determined by the Committee, but in no event may such
option price be less than the fair market value of the underlying Common Shares
at the time the Option is granted; provided, however, that in the case of an
Incentive Stock Option granted to an employee who owns stock representing more
than ten percent of the voting power of all classes of stock of the Company or
any parent or subsidiary (a "Ten Percent Employee"), such option price shall not
be less than 110% of such fair market value at the time the Option is granted.

         (b) Subject to the per participant limitation set forth in Paragraph
4(b) and the formula plan set forth in Paragraph 9, the Committee shall
determine the number of Common Shares to be subject to each Option. The number
of Common Shares subject to an outstanding Option may be reduced on a
share-for-share or other appropriate basis, as determined by the Committee, to
the extent that Common Shares under such Option are used to calculate the cash,
Common Shares, Other Company Securities or property, or other forms of payment,
or any combination thereof, received pursuant to exercise of a Stock
Appreciation Right attached to such Option, or to the extent that any other
Award granted in conjunction with such Option is paid.

         (c) The Option may not be sold, assigned, transferred, pledged,
hypothecated or otherwise disposed of, except by will or the laws of descent and
distribution, and shall be exercisable during the grantee's lifetime only by
him. Unless the Committee determines otherwise, the Option shall not be
exercisable for at least six months after the date of grant, unless the grantee
ceases employment or performance of services before the expiration of such
six-month period by reason of his disability as defined in Paragraph 13 or his
death.

         (d)      The Option shall not be exercisable:

                  (i) in the case of any Incentive Stock Option granted to a Ten
         Percent Employee, after the expiration of five years from the date it
         is granted, and, in the case of any other Option, after the expiration
         of ten years from the date it is granted. Subject to the terms of the
         formula plan set forth in Paragraph 9, any Option may be exercised
         during such period only at such time or times and in such installments
         as the Committee may establish;

                  (ii) unless payment in full is made for the shares being
         acquired thereunder at the time of exercise; such payment shall be made
         in such form (including, but not limited to, cash, Common Shares, or
         the surrender of another outstanding Award under the Plan, or any
         combination thereof) as the Committee may determine in its discretion;
         and

                  (iii) unless the person exercising the Option has been, at all
         times during the period beginning with the date of the grant of the
         Option and ending on the date of such exercise, employed by or
         otherwise preforming services for the Company, or a corporation, or a
         parent or subsidiary of a corporation, substituting or assuming the
         Option in a transaction to which Section 424(a) of the Code is
         applicable, except that

                                 Appendix B - 3
<PAGE>
                           (A) IF AN EMPLOYEE OF THE COMPANY OR A 
                  PERSON PERFORMING SERVICES FOR THE COMPANY OTHER THAN AS A
                  DIRECTOR SHALL CEASE SUCH EMPLOYMENT OR PERFORMANCE OF
                  SERVICES (OTHER THAN BY A TERMINATION OR REMOVAL FOR CAUSE)
                  WHILE HOLDING AN OPTION WHICH HAS NOT EXPIRED AND HAS NOT BEEN
                  FULLY EXERCISED, SUCH PERSON, AT ANY TIME WITHIN 9.0 DAYS (OR
                  SUCH PERIOD DETERMINED BY THE COMMITTEE) AFTER THE DATE HE
                  CEASED SUCH EMPLOYMENT OR PERFORMANCE OF SERVICES (BUT IN NO
                  EVENT AFTER THE OPTION HAS EXPIRED), MAY EXERCISE THE OPTION
                  WITH RESPECT TO ANY SHARES AS TO WHICH HE COULD HAVE EXERCISED
                  THE OPTION ON THE DATE HE CEASED SUCH EMPLOYMENT OR
                  PERFORMANCE OF SERVICES, OR WITH RESPECT TO SUCH GREATER
                  NUMBER OF SHARES AS DETERMINED BY THE COMMITTEE; OR

                           (B) IF A NON-EMPLOYEE DIRECTOR OF THE COMPANY SHALL
                  RESIGN OR SHALL OTHERWISE BE REMOVED (OTHER THAN A REMOVAL FOR
                  CAUSE) WHILE HOLDING AN OPTION WHICH HAS NOT EXPIRED AND HAS
                  NOT BEEN FULLY EXERCISED, SUCH NON-EMPLOYEE DIRECTOR, AT ANY 
                  TIME WITHIN THREE YEARS (OR SUCH PERIOD DETERMINED BY THE
                  COMMITTEE) AFTER THE DATE HE CEASED TO BE A DIRECTOR (BUT IN
                  NO EVENT AFTER THE OPTION HAS EXPIRED), MAY EXERCISE THE
                  OPTION WITH RESPECT TO ANY SHARES AS TO WHICH HE COULD HAVE
                  EXERCISED THE OPTION ON THE DATE HE CEASED TO BE A DIRECTOR,
                  OR WITH RESPECT TO SUCH GREATER NUMBER OF SHARES AS DETERMINED
                  BY THE COMMITTEE; OR

                           (deleted text (A))(C) if such person shall cease 
                  such employment or performance of services by reason of his
                  disability as defined in Paragraph 13 or early, normal or
                  deferred retirement under an approved retirement program of
                  the Company (or such other plan or arrangement as may be
                  approved by the Committee, in its discretion, for this
                  purpose) while holding an Option which has not expired and has
                  not been fully exercised, such person, at any time within
                  three years (or such period determined by the Committee) after
                  the date he ceased such employment or performance of services
                  (but in no event after the Option has expired), may exercise
                  the Option with respect to any shares as to which he could
                  have exercised the Option on the date he ceased such
                  employment or performance of services, or with respect to such
                  greater number of shares as determined by the Committee; IN
                  THE EVENT THAT SUCH A DISABLED PERSON, WITHIN THREE YEARS
                  FOLLOWING TERMINATION OF EMPLOYMENT, RESUMES HIS EMPLOYMENT OR
                  PERFORMANCE OF SERVICES FOR THE COMPANY: (i) SUCH PERSON MAY
                  EXERCISE SUCH OPTION WITH RESPECT TO ALL SHARES UNDERLYING
                  SUCH OPTION AS ORIGINALLY GRANTED; PROVIDED THAT, TO THE
                  EXTENT THAT ANY OF SUCH SHARES WERE NOT EXERCISABLE AT THE
                  TIME OF SUCH PERSON'S TERMINATION OF EMPLOYMENT OR PERFORMANCE
                  OF SERVICES BY REASON OF DISABILITY, SUCH PERSON MAY EXERCISE
                  SUCH OPTION WITH RESPECT TO SUCH UNEXERCISABLE SHARES ONLY IN
                  ACCORDANCE WITH A REVISED VESTING SCHEDULE AS DETERMINED BY
                  THE COMMITTEE AND (ii) THE EXPIRATION DATE OF SUCH OPTION
                  SHALL BE AUTOMATICALLY EXTENDED BY A PERIOD OF TIME EQUAL TO
                  THE PERIOD COMMENCING ON THE DATE THAT SUCH PERSON'S
                  EMPLOYMENT OR PERFORMANCE OF SERVICES FOR THE COMPANY WAS
                  TERMINATED BY REASON OF DISABILITY AND ENDING ON THE DATE SUCH
                  PERSON RESUMED EMPLOYMENT OR PERFORMANCE OF SERVICES FOR THE
                  COMPANY; PROVIDED THAT, NOTWITHSTANDING THE FOREGOING, THE
                  EXPIRATION DATE OF ANY INCENTIVE STOCK OPTION SHALL NOT IN ANY
                  CASE BE SO EXTENDED; or

                           (deleted text (B))(D) if any person to whom an Option
                  has been granted shall die holding an Option which has not
                  expired and has not been fully exercised, his executors,
                  administrators, heirs or distributees, as the case may be,
                  may, at any time within one year (or such other period
                  determined by the Committee) after the date of death (but in
                  no event after the Option has expired), exercise the Option
                  with respect to any shares as to which the decedent could have
                  exercised the Option at the time of his death, or with respect
                  to such greater number of shares as determined by the
                  Committee.

        (e) In the case of an Incentive Stock Option, the amount of the
aggregate fair market value of Common Shares (determined at the time of grant of
the Option pursuant to subparagraph 5(a) of the Plan) with respect to which
incentive stock options are exercisable for the first time by an employee during
any calendar year (under all such plans of his employer corporation and its
parent and subsidiary corporations) shall not exceed $100,000.

         (f) It is the intent of the Company that Nonqualified Stock Options
granted under the Plan not be classified as Incentive Stock Options, that the
Incentive Stock Options granted under the Plan be consistent with and contain or
be deemed to contain all provisions required under Section 422 and the other
appropriate provisions of the Code and any implementing regulations (and any
successor provisions thereof), and that any ambiguities in construction shall be
interpreted in order to effectuate such intent.
                                 Appendix B - 4
<PAGE>
         (g) A Purchased Option may contain such additional terms not
inconsistent with this Plan, including, but not limited to, the circumstances
under which the purchase price of such Purchased Option may be returned to the
optionee, as the Committee may determine in its sole discretion.

         6. STOCK APPRECIATION RIGHTS. The Committee may grant Stock
Appreciation Rights either alone, or in conjunction with Stock Options,
Performance Grants or other Awards, either at the time of grant or by amendment
thereafter. Each Award of Stock Appreciation Rights granted under the Plan shall
be evidenced by an instrument in such form as the Committee shall prescribe from
time to time in accordance with the Plan and shall comply with the following
terms and conditions, and with such other terms and conditions, including, but
not limited to, restrictions upon the Award of Stock Appreciation Rights or the
Common Shares issuable upon exercise thereof, as the Committee, in its
discretion, shall establish:

         (a) Subject to the per participant limitation set forth in Paragraph
4(b), the Committee shall determine the number of Common Shares to be subject to
each Award of Stock Appreciation Rights. The number of Common Shares subject to
an outstanding Award of Stock Appreciation Rights may be reduced on a
share-for-share or other appropriate basis, as determined by the Committee, to
the extent that Common Shares under such Award of Stock Appreciation Rights are
used to calculate the cash, Common Shares, Other Company Securities or property,
or other forms of payment, or any combination thereof, received pursuant to
exercise of an Option attached to such Award of Stock Appreciation Rights, or to
the extent that any other Award granted in conjunction with such Award of Stock
Appreciation Rights is paid.

         (b) The Award of Stock Appreciation Rights may not be sold, assigned,
transferred, pledged, hypothecated or otherwise disposed of, except by will or
the laws of descent and distribution, and shall be exercisable during the
grantee's lifetime only by him. Unless the Committee determines otherwise, the
Award of Stock Appreciation Rights shall not be exercisable for at least six
months after the date of grant, unless the grantee ceases employment or
performance of services before the expiration of such six-month period by reason
of his disability as defined in Paragraph 13 or his death.

         (c)      The Award of Stock Appreciation Rights shall not be 
         exercisable:

                  (i) in the case of any Award of Stock Appreciation Rights
         which is attached to an Incentive Stock Option granted to a Ten Percent
         Employee, after the expiration of five years from the date it is
         granted, and, in the case of any other Award of Stock Appreciation
         Rights, after the expiration of ten years from the date it is granted.
         Any Award of Stock Appreciation Rights may be exercised during such
         period only at such time or times and in such installments as the
         Committee may establish;

                  (ii)     unless the Option or other Award to which the Award 
         of Stock Appreciation Rights is attached is at the time exercisable; 
         and

                  (iii) unless the person exercising the Award of Stock
         Appreciation Rights has been, at all times during the period beginning
         with the date of the grant thereof and ending on the date of such
         exercise, employed by or otherwise performing services for the Company,
         except that

                  (A) if such person shall cease such employment or
                  performance of services by reason of his disability as defined
                  in Paragraph 13 or early, normal or deferred retirement under
                  an approved retirement program of the Company (or such other
                  plan or arrangement as may be approved by the Committee, in
                  its discretion, for this purpose) while holding an Award of
                  Stock Appreciation Rights which has not expired and has not
                  been fully exercised, such person may, at any time within
                  three years (or such other period determined by the Committee)
                  after the date he ceased such employment or performance of
                  services (but in no event after the Award of Stock
                  Appreciation Rights has expired), exercise the Award of Stock
                  Appreciation Rights with respect to any shares as to which he
                  could have exercised the Award of Stock Appreciation Rights on
                  the date he ceased such employment or performance of services,
                  or with respect to such greater number of shares as determined
                  by the Committee; or

                           (B) if any person to whom an Award of Stock
                  Appreciation Rights has been granted shall die holding an
                  Award of Stock Appreciation Rights which has not expired and
                  has not been fully exercised, his executors, administrators,
                  heirs or distributees, as the case may be, may at any time
                  within

         
                                 Appendix B - 5
<PAGE>
                  one year (or such other period determined by the Committee)
                  after the date of death (but in no event after the Award of
                  Stock Appreciation Rights has expired), exercise the Award of
                  Stock Appreciation Rights with respect to any shares as to
                  which the decedent could have exercised the Award of Stock
                  Appreciation Rights at the time of his death, or with
                  respect to such greater number of shares as determined by the
                  Committee.

         (d) An Award of Stock Appreciation Rights shall entitle the holder (or
any person entitled to act under the provisions of subparagraph 6(c)(iii)(B)
hereof) to exercise such Award or to surrender unexercised the Option (or other
Award) to which the Stock Appreciation Right is attached (or any portion of such
Option or other Award) to the Company and to receive from the Company in
exchange thereof, without payment to the Company, that number of Common Shares
having an aggregate value equal to (or, in the discretion of the Committee, less
than) the excess of the fair market value of one share, at the time of such
exercise, over the exercise price (or Option Price, as the case may be), times
the number of shares subject to the Award or the Option (or other Award), or
portion thereof, which is so exercised or surrendered, as the case may be. The
Committee shall be entitled in its discretion to elect to settle the obligation
arising out of the exercise of a Stock Appreciation Right by the payment of cash
or Other Company Securities or property, or other forms of payment, or any
combination thereof, as determined by the Committee, equal to the aggregate
value of the Common Shares it would otherwise be obligated to deliver. Any such
election by the Committee shall be made as soon as practicable after the receipt
by the Committee of written notice of the exercise of the Stock Appreciation
Right. The value of a Common Share, Other Company Securities or property, or
other forms of payment determined by the Committee for this purpose shall be the
fair market value thereof on the last business day next preceding the date of
the election to exercise the Stock Appreciation Right, unless the Committee, in
its discretion, determines otherwise.

         (e) A Stock Appreciation Right may provide that it shall be deemed to
have been exercised at the close of business on the business day preceding the
expiration date of the Stock Appreciation Right or of the related Option (or
other Award), or such other date as specified by the Committee, if at such time
such Stock Appreciation Right has a positive value. Such deemed exercise shall
be settled or paid in the same manner as a regular exercise thereof as provided
in subparagraph 6(d) hereof.

         (f) No fractional shares may be delivered under this Paragraph 6, but
in lieu thereof a cash or other adjustment shall be made as determined by the
Committee in its discretion.

         7. RESTRICTED STOCK. Each Award of Restricted Stock under the Plan
shall be evidenced by an instrument in such form as the Committee shall
prescribe from time to time in accordance with the Plan and shall comply with
the following terms and conditions, and with such other terms and conditions as
the Committee, in its discretion, shall establish:

         (a) Subject to the per participant limitation set forth in Paragraph
4(b), the Committee shall determine the number of Common Shares to be issued to
a participant pursuant to the Award, and the extent, if any, to which they shall
be issued in exchange for cash, other consideration, or both.

         (b) Restricted Stock awarded to a participant in accordance with the
Award shall be subject to the following restrictions until the expiration of
such period as the Committee shall determine, from the date on which the Award
is granted (the "Restricted Period"): (i) a participant to whom an award of
Restricted Stock is made shall be issued, but shall not be entitled to, the
delivery of a stock certificate, (ii) the Restricted Stock shall not be
transferable prior to the end of the Restricted Period, (iii) the Restricted
Stock shall be forfeited and the stock certificate shall be returned to the
Company and all rights of the holder of such Restricted Stock to such shares and
as a shareholder shall terminate without further obligation on the part of the
Company if the participant's continuous employment or performance of services
for the Company shall terminate for any reason prior to the end of the
Restricted Period, except as otherwise provided in subparagraph 7(c), and (iv)
such other restrictions as determined by the Committee in its discretion.

         (c) If a participant who has been in continuous employment or
performance of services for the Company since the date on which a Restricted
Stock Award was granted to him shall, while in such employment or performance of
services, die, or terminate such employment or performance of services by reason
of disability as defined in Paragraph 13 or by reason of early, normal or
deferred retirement under an approved retirement program of the Company (or such
other plan or arrangement as may be approved by the Committee in its discretion,
for this purpose) and any of such events shall occur after the date on which the
Award was granted to him and prior to the end of the Restricted Period of such
Award, the Committee may determine to cancel any and all restrictions on any or
all of the Common Shares subject to such Award.

                                 Appendix B - 6
<PAGE>
         8. PERFORMANCE GRANTS. The Award of the Performance Grant ("Performance
Grant") to a participant will entitle him to receive a specified amount
determined by the Committee (the "Actual Value"), if the terms and conditions
specified herein and in the Award are satisfied. Each Award of a Performance
Grant shall be subject to the following terms and conditions, and to such other
terms and conditions, including, but not limited to, restrictions upon any cash,
Common Shares, Other Company Securities or property, or other forms of payment,
or any combination thereof, issued in respect of the Performance Grant, as the
Committee, in its discretion, shall establish, and shall be embodied in an
instrument in such form and substance as is determined by the Committee:

         (a) Subject to the per participant limitation set forth in Paragraph
4(b), the Committee shall determine the value or range of values of a
Performance Grant to be awarded to each participant selected for an Award and
whether or not such a Performance Grant is granted in conjunction with an Award
of Options, Stock Appreciation Rights, Restricted Stock or other Award, or any
combination thereof, under the Plan (which may include, but need not be limited
to, deferred Awards) concurrently or subsequently, granted to the participant
(the "Associated Award"). As determined by the Committee, the maximum value of
each Performance Grant (the "Maximum Value") shall be: (i) an amount fixed by
the Committee at the time the Award is made or amended thereafter, (ii) an
amount which varies from time to time based in whole or in part on the then
current value of the Common Shares, Other Company Securities or property, or
other securities or property, or any combination thereof or (iii) an amount that
is determinable from criteria specified by the Committee. Performance Grants may
be issued in different classes or series having different names, terms and
conditions. In the case of a Performance Grant awarded in conjunction with an
Associated Award, the Performance Grant may be reduced on an appropriate basis
to the extent that the Associated Award has been exercised, paid to or otherwise
received by the participant, as determined by the Committee.

         (b) The award period ("Award Period") related to any Performance Grant
shall be a period determined by the Committee. At the time each Award is made,
the Committee shall establish performance objectives to be attained within the
Award Period as the means of determining the Actual Value of such a Performance
Grant. The performance objectives shall be based on such measure or measures of
performance, which may include, but need not be limited to, the performance of
the participant, the Company, one or more of its subsidiaries or one or more of
their divisions or units, or any combination of the foregoing, as the Committee
shall determine, and may be applied on an absolute basis or be relative to
industry or other indices, or any combination thereof. The Actual Value of a
Performance Grant shall be equal to its Maximum Value only if the performance
objectives are attained in full, but the Committee shall specify the manner in
which the Actual Value of Performance Grants shall be determined if the
performance objectives are met in part. Such performance measures, the Actual
Value or the Maximum Value, or any combination thereof, may be adjusted in any
manner by the Committee in its discretion at any time and from time to time
during or as soon as practicable after the Award Period, if it determines that
such performance measures, the Actual Value or the Maximum Value, or any
combination thereof, are not appropriate under the circumstances.

         (c) The rights of a participant in Performance Grants awarded to him
shall be provisional and may be canceled or paid in whole or in part, all as
determined by the Committee, if the participant's continuous employment or
performance of services for the Company shall terminate for any reason prior to
the end of the Award Period.

         (d) The Committee shall determine whether the conditions of
subparagraph 8(b) or 8(c) hereof have been met and, if so, shall ascertain the
Actual Value of the Performance Grants. If the Performance Grants have no Actual
Value, the Award and such Performance Grants shall be deemed to have been
canceled and the Associated Award, if any, may be canceled or permitted to
continue in effect in accordance with its terms. If the Performance Grants have
any Actual Value and:

                  (i) were not awarded in conjunction with an Associated Award,
         the Committee shall cause an amount equal to the Actual Value of the
         Performance Grants earned by the participant to be paid to him or his
         beneficiary as provided below; or

                  (ii) were awarded in conjunction with an Associated Award, the
         Committee shall determine, in accordance with criteria specified by the
         Committee (A) to cancel the Performance Grants, in which event no
         amount in respect thereof shall be paid to the participant or his
         beneficiary, and the Associated Award may be permitted to continue in
         effect in accordance with its terms, (B) to pay the Actual Value of the
         Performance Grants to the participant or his beneficiary as provided
         below, in which event the Associated Award may be canceled or (C) to
         pay to the participant or his beneficiary as provided below, the Actual
         Value of only a portion of the


                                 Appendix B - 7
<PAGE>

         Performance Grants, in which event all or a portion of the Associated
         Award may be permitted to continue in effect in accordance with its
         terms or be canceled, as determined by the Committee.

         Such determination by the Committee shall be made as promptly as
practicable following the end of the Award Period or upon the earlier
termination of employment or performance of services, or at such other time or
times as the Committee shall determine, and shall be made pursuant to criteria
specified by the Committee.

         Payment of any amount in respect of the Performance Grants which the
Committee determines to pay as provided above shall be made by the Company as
promptly as practicable after the end of the Award Period or at such other time
or times as the Committee shall determine, and may be made in cash, Common
Shares, Other Company Securities or property, or other forms of payment, or any
combination thereof or in such other manner, as determined by the Committee in
its discretion. Notwithstanding anything in this Paragraph 8 to the contrary,
the Committee may, in its discretion, determine and pay out the Actual Value of
the Performance Grants at any time during the Award Period.

         9.       FORMULA PLAN FOR NON-EMPLOYEE DIRECTORS.

         (A) Nonqualified Stock Options covering (deleted text 5,000) 10,000 
Common Shares shall be automatically granted to each person who is not an
employee of the Company or any of its subsidiaries and is (i) elected or
re-elected as a director of the Company at an annual meeting of the Company's
stockholders or (ii) appointed as a director of the Company in accordance with
its Bylaws following (deleted text 1994) an annual meeting (each, an "Eligible
Director"), commencing with the Company's 1996 annual meeting of stockholders,
on the next business day following each such election, reelection or
appointment, as the case may be.(deleted text Each of the three yeats after the
Company's 1994 annual meeting of stockholders, Nonqualified Stock Options
covering 5,000 shares of Common Stock shall be granted to each Eligible Director
on the next business day following the date of each such Eligible Director's
election, reelection or appointments).


(B) NONQUALIFIED STOCK OPTIONS COVERING 10,000 COMMON SHARES SHALL BE
AUTOMATICALLY GRANTED TO EACH ELIGIBLE DIRECTOR WHO IS APPOINTED OR REAPPOINTED
AS THE CHAIRMAN OF THE AUDIT, COMPENSATION OR STRATEGIC PLANNING COMMITTEE OF
THE BOARD OF DIRECTORS OR ANY ADDITIONAL PERMANENT COMMITTEES OF THE BOARD OF
DIRECTORS, COMMENCING WITH THE COMPANY'S 1996 ANNUAL MEETING OF STOCKHOLDERS, ON
THE NEXT BUSINESS DAY FOLLOWING EACH SUCH APPOINTMENT OR REAPPOINTMENT, AS THE
CASE MAY BE 

         (C) Each Nonqualified Stock Option granted to an Eligible Director
pursuant to this Paragraph 9 shall (i) have an option price equal to the fair
market value of the Common Shares on the date of grant, (ii) become exercisable
in full on the first anniversary following the date of grant; provided, however,
that a Nonqualified Stock Option granted to an Eligible Director who is
appointed to the Board will become exercisable in full on the next business day
following the later of (A) the Company's annual meeting of stockholders next
following the grant date or (B) six months following the date of grant and (iii)
have a term of ten years from the date of grant. As used herein, the term
"subsidiary" means any corporation more than 50% of whose voting stock is owned,
directly or indirectly, by the Company.

         10.      DEFERRAL OF COMPENSATION.  The Committee shall determine 
whether or not an Award shall be made in conjunction with deferral of the
participant's salary, bonus or other compensation, or any combination thereof,
and whether or not such deferred amounts may be

                  (i) forfeited to the Company or to other participants or any
         combination thereof, under certain circumstances (which may include,
         but need not be limited to, certain types of termination of employment
         or performance of services for the Company),

                  (ii)     subject to increase or decrease in value based upon
         the attainment of or failure to attain, respectively, certain 
         performance measures and/or

                  (iii) credited with income equivalents (which may include, but
         need not be limited to, interest, dividends or other rates of return)
         until the date or dates of payment of the Award, if any.

         11. DEFERRED PAYMENT OF AWARDS. The Committee may specify that the
payment of all or any portion of cash, Common Shares, Other Company Securities
or property, or any other form of payment, or any combination thereof, under an
Award shall be deferred until a later date. Deferrals shall be for such periods
or until the occurrence of such events,

                                 Appendix B - 8
<PAGE>
and upon such terms, as the Committee shall determine in its discretion.
Deferred payments of Awards may be made by undertaking to make payment in the
future based upon the performance of certain investment equivalents (which may
include, but need not be limited to, government securities, Common Shares, other
securities, property or consideration, or any combination thereof), together
with such additional amounts of income equivalents (which may be compounded and
may include, but need not be limited to, interest, dividends or other rates of
return or any combination thereof) as may accrue thereon until the date or dates
of payment, such investment equivalents and such additional amounts of income
equivalents to be determined by the Committee in its discretion.

         12. AMENDMENT OR SUBSTITUTION OF AWARDS UNDER THE PLAN. The terms of
any outstanding Award under the Plan may be amended from time to time by the
Committee in its discretion in any manner that it deems appropriate (including,
but not limited to, acceleration of the date of exercise of any Award and/or
payments thereunder); provided that no such amendment shall adversely affect in
a material manner any right of a participant under the Award without his written
consent, unless the Committee determines in its discretion that there have
occurred or are about to occur significant changes in the participant's
position, duties or responsibilities, or significant changes in economic,
legislative, regulatory, tax, accounting or cost/benefit conditions which are
determined by the Committee in its discretion to have or to be expected to have
a substantial effect on the performance of the Company, or any subsidiary,
affiliate, division or department thereof, on the Plan or on any Award under the
Plan. The Committee may, in its discretion, permit holders of Awards under the
Plan to surrender outstanding Awards in order to exercise or realize rights
under other Awards, or in exchange for the grant of new Awards, or require
holders of Awards to surrender outstanding Awards as a condition precedent to
the grant of new Awards under the Plan. This Paragraph 12 shall not apply to
grants of Nonqualified Stock Options to Eligible Directors pursuant to Paragraph
9.

         13. DISABILITY. For the purposes of this Plan, a participant shall be
deemed to have terminated his employment or performance of services for the
Company and any of its subsidiaries by reason of disability, if the Committee
shall determine that the physical or mental condition of the participant by
reason of which such employment or performance of services terminated was such
at that time as would entitle him to payment of monthly disability benefits
under any Company disability plan. If the participant is not eligible for
benefits under any disability plan of the Company, he shall be deemed to have
terminated such employment or performance of services by reason of disability if
the Committee shall determine that his physical or mental condition would
entitle him to benefits under any Company disability plan if he were eligible
therefor.

        14.      TERMINATION OF A PARTICIPANT.  For all purposes under the 
Plan, the Committee shall determine whether a participant has terminated
employment with, or the performance of services for, the Company.

         15.      DILUTION AND OTHER ADJUSTMENTS.  In the event of any change 
in the outstanding Common Shares of the Company by reason of any stock split,
dividend, split-up, split-off, spin-off, recapitalization, merger,
consolidation, rights offering, reorganization, combination or exchange of
shares, a sale by the Company of all of its assets, any distribution to
stockholders other than a normal cash dividend, or other extraordinary or
unusual event, if the Committee shall determine, in its discretion, that such
change equitably requires an adjustment in the terms of any Award or the number
of Common Shares available for Awards, such adjustment may be made by the
Committee and shall be final, conclusive and binding for all purposes of the
Plan. In the event of the proposed dissolution or liquidation of the Company, 
all outstanding Awards shall terminate immediately prior to the consummation of 
such proposed action, unless otherwise provided by the Committee.

         16.      CHANGE IN CONTROL PROVISIONS.

         (a)      IMPACT OF EVENT.  In the event of a "Change in Control" as 
defined in Paragraph 16(b) hereof the following acceleration and valuation
provisions shall apply:

                  (i) Any Stock Appreciation Rights and any Stock Options
         awarded under the Plan not previously exercisable shall become fully
         exercisable.

                  (ii) The restrictions and deferral limitations applicable to
         any Restricted Stock and other Awards payable in the form of Common
         Shares, shall lapse and such shares and awards shall be deemed fully
         vested.

 
                                 Appendix B - 9
<PAGE>
                  (iii) Any outstanding Performance Grants shall be vested and
         paid out based on the prorated target results for the Award Periods in
         question, unless the Committee provides prior to any Change in Control
         for a different payment.

                  (iv) The value of all outstanding Stock Options; Stock
         Appreciation Rights, Restricted Stock, Performance Grants and any other
         type of Award payable in the form of Common Shares, in each case to the
         extent vested, shall, unless otherwise determined by the Committee in
         its sole discretion at or after grant but prior to any Change in
         Control, be cashed out on the basis of the "Change in Control Price" as
         defined in Paragraph 16(c) hereof as of the date such Change in Control
         is determined to have occurred or such other date as the Committee may
         determine prior to the Change in Control.

         (b)      DEFINITION OF  "CHANGE IN CONTROL."  For purposes of 
Paragraph 16(a), a "Change in Control" means the happening of any of the
following:

                  (i) When any "person" as defined in Section 3(a)(9) of the
         Exchange Act and as used in Sections 13(d) and 14(d) thereof, including
         a "group" as defined in Section 13(d) of the Exchange Act but excluding
         the Company and any subsidiary and any employee benefit plan sponsored
         or maintained by the Company or any subsidiary (including any trustee
         of such plan acting as trustee), directly or indirectly, becomes the
         "beneficial owner" (as defined in Rule 13d-3 under the Exchange Act, as
         amended from time to time), of securities of the Company representing
         twenty-five percent or more of the combined voting power of the
         Company's then outstanding securities;

                  (ii) When, during any period of 12 consecutive months during
         the existence of the Plan, the individuals who, at the beginning of
         such period, constitute the Board (the "Incumbent Directors") cease for
         any reason other than death to constitute at least a majority thereof,
         provided, however, that a director who was not a director at the
         beginning of such 12-month period shall be deemed to have satisfied
         such 12-month requirement (and be an Incumbent Director) if such
         director was elected by, or on the recommendation of or with the
         approval of, at least two-thirds of the directors who then qualified as
         Incumbent Directors either actually (because they were directors at the
         beginning of such 12-month period) or by prior operation of this
         Paragraph 16(b)(ii); or

                  (iii) The approval by the stockholders of the Company of a
         transaction involving the acquisition of the Company by an entity other
         than the Company or any subsidiary through purchase of assets, by
         merger, or otherwise.

         (c) CHANGE IN CONTROL PRICE. For purposes of this Paragraph 16, "Change
in Control Price" means the highest price per share paid in any transaction
reported on any national securities exchange on which the Company's Common
Shares are listed, or paid or offered in any bona fide transaction related to a
Change in Control of the Company at any time during the sixty-day period
immediately preceding the occurrence of the Change in Control, in each case as
determined by the Committee except that, in the case of Incentive Stock Options
and Stock Appreciation Rights

relating to Incentive Stock Options, such price shall be based only on
transactions reported for the date on which the optionee exercises such Stock
Appreciation Rights or, where applicable, the date on which a cashout occurs
under Paragraph 16(a)(iv).

         17. DESIGNATION OF BENEFICIARY BY PARTICIPANT. A participant may name a
beneficiary to receive any payment to which he may be entitled in respect of any
Award under the Plan in the event of his death, on a written form to be provided
by and filed with the Committee, and in a manner determined by the Committee in
its discretion. The Committee reserves the right to review and approve
beneficiary designations. A participant may change his beneficiary from time to
time in the same manner, unless such participant has made an irrevocable
designation. Any designation of beneficiary under the Plan (to the extent it is
valid and enforceable under applicable law) shall be controlling over any other
disposition, testamentary or otherwise, as determined by the Committee in its
discretion. If no designated beneficiary survives the participant and is living
on the date on which any amount becomes payable to such a participant's
beneficiary, such payment will be made to the legal representatives of the
participant's estate, and the term "beneficiary" as used in the Plan shall be
deemed to include such person or persons. If there are any questions as to the
legal right of any beneficiary to receive a distribution under the Plan, the
Committee in its discretion may determine that the amount in question be paid to
the legal representatives of the estate of the participant, in which event the
Company, the Board and the Committee and the members thereof, will have no
further liability to anyone with respect to such amount.

                                 Appendix B - 10
<PAGE>

         18. FINANCIAL ASSISTANCE. If the Committee determines that such action
is advisable, the Company may assist any person to whom an Award has been
granted in obtaining financing from the Company (or under any program of the
Company approved pursuant to applicable law), or from a bank or other third
party, on such terms as are determined by the Committee, and in such amount as
is required to accomplish the purposes of the Plan, including, but not limited
to, to permit the exercise of an Award, the participation therein, and/or the
payment of any taxes in respect thereof. Such assistance may take any form that
the Committee deems appropriate, including, but not limited to, a direct loan
from the Company, a guarantee of the obligation by the Company, or the
maintenance by the Company of deposits with such bank or third party.

         19.      MISCELLANEOUS PROVISIONS.

         (a) No employee or other person shall have any claim or right to be
granted an Award under the Plan. Determinations made by the Committee under the
Plan need not be uniform and may be made selectively among eligible individuals
under the Plan, whether or not such eligible individuals are similarly situated.
Neither the Plan nor any action taken hereunder shall be construed as giving any
employee or other person any right to continue to be employed by or perform
services for the Company, and the right to terminate the employment of or
performance of services by any participants at any time and for any reason is
specifically reserved.

         (b) No participant or other person shall have any right with respect to
the Plan, the Common Shares reserved for issuance under the Plan or in any
Award, contingent or otherwise, until written evidence of the Award shall have
been delivered to the recipient and all the terms, conditions and provisions of
the Plan and the Award applicable to such recipient (and each person claiming
under or through him) have been met.

         (c) Except as may be approved by the Committee where such approval
shall not adversely affect compliance of the Plan with Rule 16b-3 under the
Exchange Act, a participant's rights and interest under the Plan may not be
assigned or transferred, hypothecated or encumbered in whole or in part either
directly or by operation of law or otherwise (except in the event of a
participant's death) including, but not by way of limitation, execution, levy,
garnishment, attachment, pledge, bankruptcy or in any other manner, provided,
however, that any Option or similar right (including, but not limited to, a
Stock Appreciation Right) offered pursuant to the Plan shall not be transferable
other than by will or the laws of descent and distribution and shall be
exercisable during the participant's lifetime only by him.

         (d) No Common Shares, Other Company Securities or property, other
securities or property, or other forms of payment shall be issued hereunder with
respect to any Award unless counsel for the Company shall be satisfied that such
issuance will be in compliance with applicable federal, state, local and foreign
legal, securities exchange and other applicable requirements.


         (e) It is the intent of the Company that the Plan comply in all
respects with Rule 16b-3 under the Exchange Act and Section 162(m) of the Code,
that any ambiguities or inconsistencies in construction of the Plan be
interpreted to give effect to such intention and that if any provision of the
Plan is found not to be in compliance with Rule 16b-3 or Section 162(m), such
provision shall be deemed null and void to the extent required to permit the
Plan to comply with Rule 16b-3 or Section 162(m), as the case may be.

         (f) The Company shall have the right to deduct from any payment made
under the Plan any federal, state, local or foreign income or other taxes
required by law to be withheld with respect to such payment. It shall be a
condition to the obligation of the Company to issue Common Shares, Other Company
Securities or property, other securities or property, or other forms of payment,
or any combination thereof, upon exercise, settlement or payment of any Award
under the Plan, that the participant (or any beneficiary or person entitled to
act) pay to the Company, upon its demand, such amount as may be required by the
Company for the purpose of satisfying any liability to withhold federal, state,
local or foreign income or other taxes. If the amount requested is not paid, the
Company may refuse to issue Common Shares, Other Company Securities or property,
other securities or property, or other forms of payment, or any combination
thereof. Notwithstanding anything in the Plan to the contrary, the Committee
may, in its discretion, permit an eligible participant (or any beneficiary or
person entitled to act) to elect to pay a portion or all of the amount requested
by the Company for such taxes with respect to such Award, at such time and in
such manner as the Committee shall deem to be appropriate (including, but not
limited to, by authorizing the Company to withhold, or agreeing to surrender to
the Company on or about the date such tax liability is determinable, Common
Shares, Other Company Securities or property, other securities or property, or
other forms of payment, or any combination thereof, owned by such person or a
portion of such forms of payment that would otherwise be

                                 Appendix B - 11
<PAGE>

distributed, or have been distributed, as the case may be, pursuant to such
Award to such person, having a fair market value equal to the amount of such
taxes).

         (g)      The expenses of the Plan shall be borne by the Company.

         (h) The Plan shall be unfunded. The Company shall not be required to
establish any special or separate fund or to make any other segregation of
assets to assure the payment of any Award under the Plan, and rights to the
payment of Awards shall be no greater than the rights of the Company's general
creditors.

         (i) By accepting any Award or other benefit under the Plan, each
participant and each person claiming under or through him shall be conclusively
deemed to have indicated his acceptance and ratification of, and consent to, any
action taken under the Plan by the Company, the Board or the Committee or its
delegates.

         (j) Fair market value in relation to Common Shares, Other Company
Securities or property, other securities or property or other forms of payment
of Awards under the Plan, or any combination thereof, as of any specific time
shall mean such value as determined by the Committee in accordance with
applicable law.

         (k)      The masculine pronoun includes the feminine and the singular 
includes the plural wherever appropriate.

         (l) The appropriate officers of the Company shall cause to be filed any
reports, returns or other information regarding Awards hereunder of any Common
Shares issued pursuant hereto as may be required by Section 13 or 15(d) of the
Exchange Act (or any successor provision) or any other applicable statute, rule
or regulation.

         (m) The validity, construction, interpretation, administration and
effect of the Plan, and of its rules and regulations, and rights relating to the
Plan and to Awards granted under the Plan, shall be governed by the substantive
laws, but not the choice of law rules, of the State of Delaware.

         20. PLAN AMENDMENT OR SUSPENSION. The Plan may be amended or suspended
in whole or in part at any time from time to time by the Board, but no amendment
shall be effective unless and until the same is approved by stockholders of the
Company where the failure to obtain such approval would adversely affect the
compliance of the Plan with Rule 16b-3 under the Exchange Act and with other
applicable law. No amendment of the Plan shall adversely affect in a material
manner any right of any participant with respect to any Award theretofore
granted without such participant's written consent, except as permitted under
Paragraph 12. The terms of the formula plan set forth in Paragraph 9 relating to
the amount, price and timing of grants of Nonqualified Stock Options to Eligible
Directors shall

not be amended more than once every six months, except to comport with changes
in the Code and the Employee Retirement Income Security Act of 1974, as amended,
or the rules and regulations thereunder.

         21.      PLAN TERMINATION.  This Plan shall terminate upon the earlier 
of the following dates or events to occur.

         (a)      upon the adoption of a resolution of the Board terminating 
the Plan; or

         (b) ten years from the date the Plan is initially approved and adopted
by the stockholders of the Company in accordance with Paragraph 22 hereof,
provided, however, that the Board may, prior to the expiration of such ten-year
period, extend the term of the Plan for an additional period of up to five years
for the grant of Awards other than Incentive Stock Options. No termination of
the Plan shall materially alter or impair any of the rights or obligations of
any person, without his consent, under any Award theretofore granted under the
Plan, except that subsequent to termination of the Plan, the Committee may make
amendments permitted under Paragraph 12.

         22. STOCKHOLDER ADOPTION. The Plan shall be submitted to the
stockholders of the Company, for their approval and adoption in accordance with
applicable law and Rule 16b-3 under the Exchange Act and Section 162(m) under
the Code. The Plan shall not be effective and no Award shall be made hereunder
unless and until the Plan has been so approved and adopted.

                                 Appendix B - 12
<PAGE>

                                  COMMON STOCK
                      SERIES A CONVERTIBLE PREFERRED STOCK
                           NAPRO BIOTHERAPEUTICS, INC.

                    PROXY SOLICITED BY THE BOARD OF DIRECTORS
       FOR THE ANNUAL MEETING OF STOCKHOLDERS TO BE HELD ON JULY 30, 1996

         THE UNDERSIGNED HEREBY APPOINTS LEONARD P. SHAYKIN, STERLING K.
AINSWORTH AND PATRICIA A. PILIA, OR ANY OF THEM, WITH FULL POWER OF
SUBSTITUTION, AS A PROXY OR PROXIES TO REPRESENT THE UNDERSIGNED AT THE ANNUAL
MEETING (THE "ANNUAL MEETING") OF STOCKHOLDERS OF NAPRO BIOTHERAPEUTICS, INC.
(THE "COMPANY") TO BE HELD ON JULY 30, 1996, AT 9:00 A.M. AT THE CONFERENCE
CENTER AT THE RAINTREE PLAZA HOTEL, 1850 INDUSTRIAL CIRCLE, LONGMONT, COLORADO,
AND AT ANY ADJOURNMENTS OR POSTPONEMENTS THEREOF, AND TO VOTE THEREAT ALL THE
SHARES OF COMMON STOCK, $.0075 PAR VALUE PER SHARE AND SERIES A CONVERTIBLE
PREFERRED STOCK, $.001 PAR VALUE PER SHARE, HELD OF RECORD BY THE UNDERSIGNED AT
THE CLOSE OF BUSINESS ON MAY 31, 1996, WITH ALL THE POWER THAT THE UNDERSIGNED
WOULD POSSESS IF PERSONALLY PRESENT, AS DESIGNATED ON THE REVERSE SIDE.

         SHARES WILL BE VOTED AS SPECIFIED. THE BOARD OF DIRECTORS RECOMMENDS A
VOTE FOR AND APPROVAL OF THE PROPOSALS. IF NO SPECIFICATION IS MADE, THIS PROXY
WILL BE VOTED IN FAVOR OF EACH OF THE PROPOSALS IN ACCORDANCE WITH THE BOARD OF
DIRECTORS RECOMMENDATIONS. THE PROXIES OR SUBSTITUTES MAY VOTE ACCORDINGLY IN
THEIR DISCRETION UPON ANY OTHER BUSINESS THAT MAY PROPERLY COME BEFORE THE
ANNUAL MEETING OR ANY ADJOURNMENTS THEREOF.

                (CONTINUED AND TO BE SIGNED ON THE REVERSE SIDE)
<PAGE>

   X     PLEASE MARK YOUR VOTES AS IN THIS EXAMPLE
- ------

1.  ELECTION OF DIRECTORS:
         CLASS I NOMINEES:          LEONARD P. SHAYKIN
         (TO SERVE UNTIL            PHILLIP FROST
         1997 ANNUAL MEETING)       ARTHUR H. HAYES, JR.

         CLASS II NOMINEES:         E. GARRETT BEWKES, JR.
         (TO SERVE UNTIL            VAUGHN D. BRYSON
         1998 ANNUAL MEETING)       PATRICIA A. PILIA

         CLASS III NOMINEES:        STERLING K. AINSWORTH
         (TO SERVE UNTIL            MARK B. HACKEN
         1999 ANNUAL MEETING)       RICHARD C. PFENNIGER, JR.

         FOR               WITHHOLD AUTHORITY TO VOTE FOR ALL NOMINEES LISTED
           [ ]                                        [ ]
         TO WITHHOLD AUTHORITY TO VOTE FOR ANY INDIVIDUAL NOMINEE, WRITE THAT
         NOMINEE'S NAME ON THE LINE PROVIDED BELOW:

         ---------------------------

2. AMENDMENTS TO THE COMPANY'S AMENDED AND RESTATED CERTIFICATE OF
INCORPORATION: TO (A) CLASSIFY THE BOARD OF DIRECTORS INTO THREE CLASSES; (B)
PROVIDE THAT DIRECTORS MAY BE REMOVED ONLY FOR CAUSE AND ONLY WITH THE APPROVAL
OF THE HOLDERS OF AT LEAST 80% OF THE VOTING POWER OF THE COMPANY; AND (C)
REQUIRE THE CONCURRENCE OF THE HOLDERS OF AT LEAST 80% OF THE VOTING POWER OF
THE COMPANY TO ALTER, AMEND OR REPEAL, OR TO ADOPT ANY PROVISION INCONSISTENT
WITH, THE FOREGOING AMENDMENTS;

            FOR      [ ]      AGAINST         [ ]       ABSTAIN          [ ]

3. AMENDMENTS TO THE COMPANY'S 1994 LONG-TERM PERFORMANCE INCENTIVE PLAN (THE
"1994 PLAN") TO: (I) INCREASE THE MAXIMUM NUMBER OF SHARES OF COMMON STOCK
ISSUABLE AS AWARDS UNDER THE PLAN FROM 375,000 TO 875,000 (OF WHICH 180,000
SHARES WILL BE RESERVED FOR ISSUANCE TO NON-EMPLOYEE DIRECTORS UNDER THE FORMULA
PROVISIONS OF THE 1994 PLAN); (II) PROVIDE THAT THE MAXIMUM NUMBER OF SHARES OF
COMMON STOCK THAT ANY PARTICIPANT MAY BE GRANTED UNDER AWARDS IN ANY ONE TAXABLE
YEAR WILL BE 200,000 SHARES; (III) INCREASE THE NUMBER OF SHARES OF COMMON STOCK
UNDERLYING AUTOMATIC GRANTS OF NON-QUALIFIED STOCK OPTIONS TO NON-EMPLOYEE
DIRECTORS FROM 5,000 TO 10,000 SHARES; (IV) PROVIDE FOR AUTOMATIC GRANTS OF
NON-QUALIFIED STOCK OPTIONS TO PURCHASE 10,000 SHARES OF COMMON STOCK TO EACH
DIRECTOR WHO SERVES AS CHAIRMAN OF THE AUDIT, COMPENSATION AND STRATEGIC
PLANNING COMMITTEES OF THE BOARD OF DIRECTORS; (V) PROVIDE FOR A PERIOD OF 90
DAYS FOLLOWING TERMINATION OF AN EMPLOYEE'S RELATIONSHIP WITH THE COMPANY, OR
FOR A PERIOD OF THREE YEARS IN THE CASE OF A RESIGNATION OR REMOVAL OF A
NON-EMPLOYEE DIRECTOR, DURING WHICH VESTED STOCK OPTIONS GRANTED UNDER THE 1994
PLAN WILL REMAIN EXERCISABLE, UNLESS AN EMPLOYEE OR A NON-EMPLOYEE DIRECTOR, AS
THE CASE MAY BE, IS TERMINATED OR REMOVED FOR CAUSE; AND (VI) PROVIDE THAT PLAN
PARTICIPANTS WHO RESUME EMPLOYMENT OR PERFORMANCE OF SERVICES FOR THE COMPANY
AFTER TERMINATION BY REASON OF DISABILITY MAY EXERCISE UNVESTED STOCK OPTIONS IN
ACCORDANCE WITH A REVISED VESTING SCHEDULE AND THAT THE EXPIRATION DATE OF SUCH
STOCK OPTIONS (OTHER THAN INCENTIVE STOCK OPTIONS) BE AUTOMATICALLY EXTENDED BY
THE LENGTH OF TIME SUCH PARTICIPANT REMAINED TERMINATED BY REASON OF DISABILITY.

            FOR      [ ]      AGAINST         [ ]       ABSTAIN          [ ]

4.  TO RATIFY THE SELECTION BY THE BOARD OF DIRECTORS OF ERNST & YOUNG LLP AS 
THE COMPANY'S INDEPENDENT AUDITORS FOR THE YEAR ENDING DECEMBER 31, 1996;

            FOR      [ ]      AGAINST         [ ]       ABSTAIN          [ ]


PLEASE DATE AND SIGN THIS PROXY AND RETURN IT IN THE ENCLOSED ENVELOPE.

SIGNATURE(S)                                          DATE
           -------------------------------------------    --------------------
NOTE:  PLEASE SIGN THIS PROXY AS YOUR NAME APPEARS HEREON, INCLUDING THE TITLE
"EXECUTOR," "TRUSTEE," ETC. IF SUCH IS INDICATED. IF JOINT ACCOUNT, EACH JOINT
OWNER SHOULD EACH SIGN. IF STOCK IS HELD BY A CORPORATION, THIS PROXY SHOULD BE
EXECUTED BY A PROPER OFFICER THEREOF.



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