NAPRO BIOTHERAPEUTICS INC
8-K, 1998-04-08
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                                        SECURITIES AND EXCHANGE COMMISSION
                                               WASHINGTON, DC 20549




                                                     FORM 8-K

                                                  CURRENT REPORT


          Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934



              Date of report (Date of earliest event reported): March 20, 1998

                                            NAPRO BIOTHERAPEUTICS, INC.
                              (Exact Name of Registrant as Specified in Charter)


 Delaware                         0-243201                 84-1187753
(State or Other Jurisdiction of  (Commission File Number) (I.R.S. Employer
Incorporation)                                            Identification Number)


                                              6304 Spine Road, Unit A
                                              Boulder, Colorado          80301
                              (Address of Principal Executive Offices)(Zip code)


              Registrant's telephone number, including area code: (303) 530-3891

<PAGE>
Item 5.  Other Events

     As  previously  reported,  on January 28,  1998,  the Company  entered into
definitive agreements relating to modification of certain terms of its 5% Senior
Convertible Notes due June 4, 2000 (the "Notes") and Series C Senior Convertible
Preferred  Stock (the  "Preferred  Stock").  On March 20 and March 31,  1998 the
Company  entered  into letter  agreements  with the holders of the Notes and the
holder of the Preferred Stock, respectively, further modifying such terms.
 
    The March 20 and 31, 1998 letter  agreements have been filed as exhibits to
this Report and are  incorporated  herein by this reference.  The description of
provisions  of the  letter  agreements  in this  Report  does not  purport to be
complete and is qualified in its entirety by reference to such exhibits.

Item 7.       Financial Statements, Pro Forma Financial Information and Exhibits

         (c)      Exhibits.


Exhibit No.                   Exhibit Description

4.1                         Letter Agreement, dated as of March 20, 1998,
                            by and among the Registrant and the noteholders
                            named therein.



4.2                         Letter Agreement, dated as of March 31, 1998,
                            by and between the Registrant and Advantage Fund II,
                            Ltd.


                                                    SIGNATURES

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                                    NAPRO BIOTHERAPEUTICS, INC.



                                                    By:  \s\ Gordon H. Link, Jr.
                                                             Gordon H. Link, Jr.
                                                         Chief Financial Officer

Date:  April 8, 1998

<PAGE>





                                                  March 20, 1998



NaPro BioTherapeutics, Inc.
6304 Spine Road
Unit A
Boulder, Colorado  80301

Attn:  Vice President and Chief Financial Officer

Gentlemen:

         Reference is made to (i) the Note Purchase  Agreements  (the  "Purchase
Agreements")  dated as of May 30,  1997 among  NaPro  BioTherapeutics,  Inc.,  a
Delaware corporation (the "Company"), and the various Buyers parties thereto, as
amended to date, (ii) the Engagement  Letter dated May 12, 1997 (the "Engagement
Letter")  between  the  Company  and  Diaz &  Altschul  Capital,  LLC  ("Diaz  &
Altschul");  (iii)  each of the  Senior  Convertible  Notes of the  Company,  as
amended to date (each,  a "Note");  (iv)  warrants to purchase an  aggregate  of
323,700 shares of common stock of the Company,  issued to the Buyers and certain
of which are held by Diaz & Altschul  Group,  LLC (the  "Warrants")  and (v) the
Amendment  Agreement  dated  January  28,  1998 by and among the Company and the
holders named therein (the "Amendment Agreement"). Capitalized terms used herein
and not  defined  shall  have  the  meanings  assigned  to them in the  Purchase
Agreements and the Notes, as amended by the Amendment Agreement.

         The Holders agree severally with the Company as follows:

     1. The definition of "Purchase  Price" in the Warrants is hereby amended by
deleting "$2.50" and replacing it with "$1.50."

     2. For a period of 130 days  following the date hereof,  the  definition of
"1998  Redemption  Price" in the Notes is hereby amended by deleting  "130%" and
replacing it with "110%."

     3. The Company  hereby  represents  that it is  currently in the process of
seeking  financing  alternatives,  the  proceeds  of which  may be used,  in the
discretion of the Company,  to redeem the Notes in  accordance  with their terms
(as amended hereby).

         If the foregoing correctly sets forth our agreement, please so indicate
by signing the appropriate line below,  whereupon this letter shall constitute a
binding agreement between the Company and each Holder.




<PAGE>


NaPro BioTherapeutics, Inc.
March 20, 1998
Page 2

                                                    NAPRO BIOTHERAPEUTICS, INC.



                                                    By:  \s\ Gordon H. Link, Jr.
                                                             Gordon H. Link, Jr.
                                                         Chief Financial Officer

Agreed and accepted:

DELTA OPPORTUNITY FUND, LTD.


By:     /s/
         Name:
         Title:


NELSON PARTNERS


By:     /s/
         Name:
         Title:


OLYMPUS SECURITIES, LTD.


By:     /s/
         Name:
         Title:


<PAGE>


NaPro BioTherapeutics, Inc.
March 20, 1998
Page 3


OTATO LIMITED PARTNERSHIP


By:     /s/
         Name:
         Title:

DIAZ & ALTSCHUL GROUP, LLC


By:     /s/
         Name:
         Title:


OMICRON PARTNERS, L.P.


By:     /s/
         Name:
         Title:


                                                  March 31, 1998



NaPro BioTherapeutics, Inc.
Unit A
6304 Spine Road
Boulder, Colorado  80301

Attn:  Vice President and Chief Financial Officer

Gentlemen:

     Reference  is made to (i) the  Subscription  Agreement  (the  "Subscription
Agreement")  dated as of December 8, 1997 by and between NaPro  BioTherapeutics,
Inc., a Delaware corporation (the "Company" or the "Corporation"), and Advantage
Fund II, Ltd. (the  "Holder");  (ii) the Certificate of Designations of Series C
Senior  Convertible  Preferred  Stock (the  "Certificate");  (iii)  warrants  to
purchase  175,000  shares of common stock of the  Company,  issued to the Holder
(the "Warrants"); and (iv) the Amendment Agreement dated January 28, 1998 by and
between  the Company and the Holder  (the  "Amendment  Agreement").  Capitalized
terms used herein and not defined  shall have the  meanings  assigned to them in
the Subscription Agreement, the Certificate and the Amendment Agreement.

         The Holder and the Company agree as follows:

     1. For purposes of paragraph (c) of the Amendment Agreement, a new sentence
is  deemed  to be added  before  the  final  sentence  of  Section  10(c) of the
Certificate to read as follows:

         "Notwithstanding  clause  (B)  (but  subject  to  clause  (A))  of  the
         preceding  sentence,  the holder of Series C  Preferred  shall have the
         right at any time on or prior to  December  31,  1998 to  convert  such
         additional  shares of Series C Preferred as will result in the issuance
         of an additional 250,000 shares of Common Stock."

     2. For a period of 120 days  following the date hereof,  the  definition of
"1998 Redemption Price" in the Amendment Agreement is hereby amended by deleting
"130%" and replacing it with "110%."

     3. The Company  hereby  represents  that it is  currently in the process of
seeking  financing  alternatives,  the  proceeds  of which  may be used,  in the
discretion of the Company, to redeem the shares of Convertible  Preferred Stock,
Series C in accordance with their terms and the terms of the Amendment Agreement
(as amended hereby).




<PAGE>


NaPro BioTherapeutics, Inc.
March 31, 1998
Page 2

         If the foregoing correctly sets forth our agreement, please so indicate
by signing the appropriate line below,  whereupon this letter shall constitute a
binding agreement between the Company and the Holder.



                                                    NAPRO BIOTHERAPEUTICS, INC.



                                                    By:  \s\ Gordon H. Link, Jr.
                                                             Gordon H. Link, Jr.
                                                         Chief Financial Officer


<PAGE>


NaPro BioTherapeutics, Inc. 
March 31, 1998
Page 3

Agreed and accepted:

ADVANTAGE FUND II, LTD.


By:      /s/
         Name:
         Title:





<PAGE>




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