PROSPECTUS SUPPLEMENT
(To Prospectus dated August 22, 1995)
NAPRO BIOTHERAPEUTICS, INC.
Shares of Common Stock ($.0075 par value)
The Prospectus Supplement amends and supplements information contained
in the section captioned "Selling Stockholders" of that certain Prospectus dated
August 22, 1995 relating to shares of Common Stock of NaPro BioTherapeutics,
Inc.
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SELLING STOCKHOLDERS
This Prospectus relates to an aggregate of up to 481,820 shares of
Common Stock consisting of up to 481,820 shares of Common Stock into which up to
481,820 shares Exchangeable Preferred Stock of NaPro BioTherapeutics, (Canada)
Inc. (the "Exchangeable Preferred Stock") have been exchanged or are
exchangeable. The Prospectus originally included shares of Common Stock issuable
by the Company upon the conversion of the Company's Convertible Preferred Stock,
Series A, and upon the exchange of the Exchangeable Preferred Stock.
The Company has agreed to register the public offering of the Selling
Stockholders' Shares under the Securities Act concurrently with this offering
and to pay all expenses in connection therewith. None of the Selling
Stockholders has ever held any position or office with the Company or had any
other material relationship with the Company. One or more of the Selling
Stockholders may donate or transfer as gifts some of the shares and any such
donees who transfer shares so received as donations or gifts shall be included
among the "Selling Stockholders." The Company will not receive any of the
proceeds from the sale of the Selling Stockholders' Shares.
The following table sets forth certain information with respect to the
Selling Stockholders as of April 29, 1998.
<TABLE>
<CAPTION>
Ownership of Percentage
Shares of Ownership of
Ownership of Common Stock Common Stock
Shares of Amount of after Sale of after Sale of
Common Selling Selling Selling
Stock Prior Stockholders' Stockholders' Stockholders'
Selling Stockholders to Sale Shares Offered Shares Shares
- ------------------------------------------ ----------------- ------------------ --------------------- ----------------------
<S> <C> <C> <C> <C>
Royal Bank Investment
Management 240,900 240,900 -0- -0-
Royal Trust Corporation 140,920 140,920 -0- -0-
Working Opportunity Fund 77,272 77,272 -0- -0-
Donald C. Webster 22,728 22,728 -0- -0-
</TABLE>
The date of this Prospectus Supplement is May 1, 1998.
<PAGE>
