NAPRO BIOTHERAPEUTICS INC
424B3, 1998-02-04
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                                                                  Rule 424(b)(3)
PROSPECTUS SUPPLEMENT
(To Prospectus dated December 31, 1997)

                                            NAPRO BIOTHERAPEUTICS, INC.
                        1,000,000 Shares of Common Stock

                               RECENT DEVELOPMENT

MODIFICATION OF TERMS OF SERIES C SENIOR CONVERTIBLE PREFERRED STOCK AND
SENIOR CONVERTIBLE NOTES

         On January 28, 1998,  the Company  entered into an Amendment  Agreement
with the Selling Stockholder of the Series C Senior Convertible Preferred Stock,
which  amended  certain  terms of the  related  Subscription  Agreement  and the
related  Warrants  and  established  additional  rights and  obligations  of the
Company and such  Selling  Stockholder  with  respect to the  Preferred  Shares.
Pursuant  to the  Amendment  Agreement,  the Selling  Stockholder  agreed not to
exercise  its  conversion  rights with respect to the  Preferred  Shares and the
Company granted the Selling  Stockholder  certain exchange rights.  Beginning on
January 28, 1998, the Preferred  Shares are  exchangeable  for Common Stock at a
price per share of Common Stock at a discount of 5% from the market price of the
Common Stock  computed  from selected  dates prior to the exchange.  The Selling
Stockholder  agreed to limit its exchanges of the Preferred  Shares into 150,000
of  Common  Stock per month in 1998 at an  exchange  price of less than $4.  The
exercise  price of the Warrants was changed to $2.50 per share of Common  Stock.
The Company has agreed to solicit a stockholder vote on or prior to June 1, 1998
to increase the number of  authorized  shares of Common Stock and  authorize the
issuance of shares of Common  Stock equal to 20% or more of the Common  Stock or
20% of more of the voting power  outstanding  before such issuance for less than
the greater of book or market value.  The Amendment  Agreement has been filed by
the  Company as an exhibit to its Current  Report on Form 8-K dated  January 28,
1998, which is incorporated herein by reference.

         On January 28, 1998,  the Company  entered into an Amendment  Agreement
with the Selling  Stockholders of its Senior  Convertible  Notes,  which amended
certain  terms of the Notes,  the note  purchase  agreement  with respect to the
Notes,  and the related  Warrants.  Pursuant  to the  Amendment  Agreement,  the
Selling  Stockholders  agreed to limit  conversions  of the Notes  into  300,000
shares of Common Stock per month in 1998 at a conversion  price of less than $4.
The  exercise  price of the related  Warrants  was changed to $2.50 per share of
Common Stock.  The Company has agreed to solicit a stockholder  vote on or prior
to June 1, 1998 to increase the number of authorized  shares of Common Stock and
authorize  the  issuance  of shares of Common  Stock equal to 20% or more of the
Common Stock or 20% of more of the voting power outstanding before such issuance
for less than the greater of book or market value.  The Amendment  Agreement has
been filed by the Company as an exhibit to its Current  Report on Form 8-K dated
January 28, 1998, which is incorporated herein by reference.


                The date of this  Prospectus  Supplement is February 3, 1998.






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