NAPRO BIOTHERAPEUTICS INC
DEF 14A, 1998-04-29
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                     SCHEDULE 14A INFORMATION
         Proxy Statement Pursuant to Section 14(a) of the
                 Securities Exchange Act of 1934


Filed by the Registrant  [X]
Filed by a Party other than the Registrant  []

Check the Appropriate box:
[ ]     Preliminary Proxy Statement
[ ]     Confidential, for Use of the Commission Only
        (as permitted by Rule 14a-6(e)(2))
[X]     Definitive Proxy Statement
[ ]     Definitive Additional Materials
[ ]     Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12


                   NAPRO BIOTHERAPEUTICS, INC.
         (Name of Registrant as Specified in Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):
[X]  No fee required.
[ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.
     1)   Title of each class of securities to which transaction applies:
     2)   Aggregate number of securities to which transaction applies:
     3)   Per unit price or other underlying value of transaction computed 
          pursuant to Exchange Act
          Rule 0-11 (Set forth the amount on which the filing fee is calculated
          and state how it was determined):
     4)   Proposed maximum aggregate value of transaction:
     5)   Total fee paid:
[ ]       Fee paid previously with preliminary materials.
[ ]       Check box if any part of the fee is offset as provided by Exchange
          Act Rule 0-11(a)(2) and identify the filing for which the offsetting
          fee was paid previously. Identify the previous filing by registration
          statement number, or the form or Schedule and the date of its filing.
     1)  Amount Previously Paid:
     2)  Form Schedule or Registration Statement No.:
     3)  Filing Party:
     4)  Date Filed:

<PAGE>


                   NaPro BioTherapeutics, Inc.
                     6304 Spine Road, Unit A
                     Boulder, Colorado 80301
               -----------------------------------

             Notice of Annual Meeting of Stockholders
                    to be held on May 28, 1998
               -----------------------------------

TO THE STOCKHOLDERS OF NAPRO BIOTHERAPEUTICS, INC.

     NOTICE IS HEREBY  GIVEN that the Annual  Meeting of  Stockholders  of NaPro
BioTherapeutics,  Inc. (the "Company"), a Delaware corporation,  will be held on
May 28, 1998, at 9:00 A.M. at the conference center at the Raintree Plaza Hotel,
1850 Industrial Circle, Longmont, Colorado, for the following purposes:

     1. To elect two Class II directors  to serve until the 2001 annual  meeting
of stockholders;

     2. To approve the issuance of 20% or more of the  Company's  voting  common
stock,  $0.0075 par value ("Common  Stock"),  at discounts of up to 10% from its
market  value as of  certain  dates in  connection  with  each of the  Company's
currently   outstanding  Senior  Convertible  Notes  and  Series  C  Convertible
Preferred Stock;

     3.  To  approve  an  amendment  to  the  Company's   Amended  and  Restated
Certificate  of  Incorporation  increasing  the number of  authorized  shares of
Common Stock;

     4. To approve an  amendment to the  Company's  1994  Long-Term  Performance
Incentive  Plan  increasing  the  number  of shares  of  Common  Stock  issuable
thereunder;

     5. To ratify the  selection  by the Board of Directors of Ernst & Young LLP
as the Company's independent auditors for the year ending December 31, 1998; and

     6. To transact such other  business as may properly come before the meeting
or any adjournment or postponement of the meeting.

     The Board of Directors  has fixed the close of business on April 2, 1998 as
the record date for the determination of stockholders  entitled to notice of and
to vote at this Annual Meeting and at any adjournment or postponement thereof.


     ALL  STOCKHOLDERS  ARE CORDIALLY  INVITED TO ATTEND THE MEETING.  TO ENSURE
YOUR REPRESENTATION AT THE MEETING,  HOWEVER,  YOU ARE ENCOURAGED TO MARK, SIGN,
DATE, AND RETURN THE ENCLOSED PROXY AS PROMPTLY AS POSSIBLE.  A POSTAGE  PREPAID
ENVELOPE IS ENCLOSED FOR THAT PURPOSE. ANY STOCKHOLDER ATTENDING THE MEETING MAY
VOTE IN PERSON EVEN IF THAT STOCKHOLDER HAS RETURNED A PROXY.


                              By Order of the Board of Directors



                              Patricia A. Pilia, Ph.D.
                              Secretary

Boulder, Colorado
April 27, 1998

<PAGE>


                   NaPro BioTherapeutics, Inc.
                     6304 Spine Road, Unit A
                     Boulder, Colorado 80301

                         PROXY STATEMENT

General

     The  enclosed  proxy  is  solicited  by the  Board  of  Directors  of NaPro
BioTherapeutics,  Inc. (the  "Company" or "NaPro") for use at the Annual Meeting
of Stockholders to be held on May 28, 1998, at 9:00 A.M. (the "Annual  Meeting")
at the conference  center at the Raintree Plaza Hotel,  1850 Industrial  Circle,
Longmont,  Colorado,  or at any adjournment or postponement of that meeting, for
the purposes set forth in the  foregoing  Notice of Annual  Meeting.  This Proxy
Statement is being  furnished to holders of the  Company's  voting common stock,
$0.0075 par value per share ("Common  Stock"),  as of April 2, 1998.  Unless the
context otherwise requires, the terms, "Company" and "NaPro" include the Company
and each of its subsidiaries.

     This Proxy  Statement  and  accompanying  proxy is being mailed on or about
April 29, 1998 to all stockholders entitled to vote at the meeting.


Annual Report

     The Annual Report to Stockholders covering the year ended December 31, 1997
including audited financial statements is enclosed herewith. This Annual Report
to Stockholders does not form any part of the material for the solicitation of
proxies.


Stockholder Proposals

     Proposals  by  stockholders  that  are  intended  to be  presented  at  the
Company's 1999 Annual Meeting of Stockholders  must be received by the Secretary
of the Company not later than  December 31, 1998, in order to be included in the
proxy statement and proxy relating to the 1999 Annual Meeting.


Voting Securities, Revocability of Proxy

     Only  stockholders of record at the close of business on April 2, 1998 (the
"Record Date") are entitled to notice of and to vote at the meeting. As of April
2, 1998,  there were 14,776,287  shares of Common Stock  outstanding.  Each such
share is  entitled  to one vote.  There is no other  class of voting  securities
outstanding.   Abstentions   and  broker  votes  are  counted  for  purposes  of
determining the presence or absence of a quorum for the transaction of business.
For  Proposal 1,  directors  are elected by a plurality of the votes cast at the
Annual Meeting.  Approval of Proposal 2, which would approve the issuance of 20%
or more of the outstanding  shares of the Company's Common Stock at discounts of
up to 10% from its market value as of certain dates in  connection  with each of
the  Company's  currently  outstanding  Senior  Convertible  Notes Due 2000 (the
"Convertible  Notes")  and  Series C Senior  Convertible  Preferred  Stock  (the
"Convertible  Preferred Stock"),  requires the affirmative vote of a majority of
the total votes cast on the proposal in person or by proxy. Approval of Proposal
3, which would  approve an  amendment  to the  Company's  Amended  and  Restated
Certificate of Incorporation (the "Certificate of Incorporation") increasing the
authorized number of shares of Common Stock,  requires the affirmative vote of a
majority  of the  shares of Common  Stock  outstanding  as of the  Record  Date.
Approval of Proposal 4, which would approve an amendment to the  Company's  1994
Long-Term  Performance Incentive Plan (the "1994 Plan") increasing the number of
shares of Common  Stock  issuable  thereunder  from  875,000 to  1,575,000,  and
Proposal  5,  which  would  ratify  the  selection  of Ernst & Young  LLP as the
Company's independent auditors, each requires the affirmative vote of a majority
of the total votes cast on such  proposal in person or by proxy.  All votes will
be tabulated by the inspector of election  appointed  for the meeting,  who will
separately tabulate affirmative and negative votes, and broker non-votes. Broker
non-votes  are not counted for any purpose in  determining  whether a matter has
been approved.

     Any  stockholder  giving a proxy has the power to revoke it any time before
it is  exercised.  Proxies  may be revoked by filing with the  Secretary  of the
Company at the principal executive office of the Company,  6304 Spine Road, Unit
A, Boulder,  Colorado, 80301, a written notice of revocation, or a duly executed
proxy  bearing a later date.  Proxies may also be revoked by  attendance  at the
Annual Meeting and an election to vote in person.

     The cost of solicitation of proxies will be paid by the Company.  Copies of
solicitation material will be furnished to brokers,  fiduciaries, and custodians
to forward to beneficial owners of Common Stock held in their names. The Company
will  reimburse  brokers and other  persons  representing  beneficial  owners of
shares for their expenses in forwarding solicitation material to such beneficial
owners.  Original  solicitation  of  proxies  by  mail  may be  supplemented  by
telephone,  telegram or personal  solicitation  by directors,  officers or other
regular  employees of the Company.  No additional  compensation  will be paid to
those persons for such services. In addition,  the Company has engaged MacKenzie
Partners,  Inc. ("MacKenzie  Partners") to assist in the solicitation of proxies
for the Annual  Meeting.  MacKenzie  Partners may contact  holders of the Common
Stock in person,  by telephone or by use of the mails to encourage their vote in
favor of the  proposals  presented.  The  Company  anticipates  that the cost of
engaging MacKenzie Partners will approximate $10,000.


Security Ownership of Certain Beneficial Owners and Management

     The  following  table sets forth certain  information  as of April 2, 1998,
regarding  ownership of the Common Stock by (i) persons  believed by the Company
to be the beneficial owners of more than five percent of its outstanding  Common
Stock; (ii) by each director and nominee for director and by the officers of the
Company  named  in  the  Summary   Compensation   Table  (the  "Named  Executive
Officers");  and (iii) by all current  executive  officers and  directors of the
Company as a group.  Unless  otherwise  noted,  all addresses are care of: NaPro
BioTherapeutics, Inc., 6304 Spine Road, Unit A, Boulder, Colorado 80301.

                                                  Number of           
Name of Director, Officer or                      Shares of           Percent of
Beneficial Owner (1)                             Common Stock           Class
- ------------------------------                 -----------------     -----------
Sterling K. Ainsworth                             1,070,152  (2)         7.2%

Leonard P. Shaykin                                       699,215         4.7%
                                               
Patricia A. Pilia                                   281,676  (3)         1.9%
                                              
Gordon H. Link, Jr.                                   34,401 (4)          *
                                               
James D. McChesney                                           625          *
                                               
Arthur H. Hayes, Jr.                                           0          *
                                               
Mark B. Hacken                                                 0          *
                                             
Randolph C. Steer                                              0          *
                                              
All Directors and Executive Officers as a          2,089,369 (5)        14.1%
Group (10 persons)
                                             
D&N Holding Company                                1,126,398 (6)         7.6%
   c/o IVAX Corporation
   8800 Northwest 36th Street
   Miami,  Florida 33178
                                            
State of Wisconsin Investment Board                1,069,500 (7)         7.2%
   P.O. Box 7842
   Madison, Wisconsin 53707
                                              
- ----------
* Less than 1%.
(1)  Unless otherwise noted, the Company believes that all persons named in the
     table have sole voting and investment power with respect to all shares of
     Common Stock beneficially owned by them.

(2)  Includes 16,000 shares of Common Stock issuable upon exercise of stock
     options held by Dr. Ainsworth and 42,550 shares of Common Stock gifted by
     Dr. Ainsworth to relatives and certain other persons that Dr. Ainsworth may
     be deemed to beneficially own by virtue of holding powers of attorney to
     vote and take certain other actions with respect to such shares. Dr.
     Ainsworth, who is engaged to be married to Dr. Pilia, disclaims beneficial
     ownership of the shares of Common Stock beneficially owned by Dr. Pilia and
     the gifted shares over which Dr. Ainsworth holds powers of attorney.

(3)  Includes 10,800 shares of Common Stock gifted by Dr. Pilia to relatives and
     certain other persons that Dr. Pilia may be deemed to beneficially own by
     virtue of holding powers of attorney to vote and take certain other actions
     with respect to such shares. Dr. Pilia disclaims beneficial ownership of
     shares of Common Stock beneficially owned by Dr. Ainsworth and the gifted
     shares over which Dr. Pilia holds powers of attorney. See note (2) above.

(4)  Includes 13,334 shares of Common Stock issuable upon the exercise of stock 
     options held by Mr. Link.

(5)  Includes an aggregate of 29,334 shares of Common Stock issuable upon 
     exercise of outstanding stock options held by such persons.

(6)  Information as to beneficial ownership of Common Stock by IVAX Corporation
     ("IVAX") and D&N Holding Company ("D&N") is based upon filings on Schedule
     13G made by IVAX. Such shares are held directly by D&N. Under a Termination
     Agreement, dated March 20, 1998, among the Company, IVAX, Baker Norton
     Pharmaceuticals, Inc., a subsidiary of IVAX ("BNP"), and D&N, BNP
     transferred these shares to the Company on April 9, 1998.

(7)  Information in the table as to beneficial ownership of Common Stock by the
     State of Wisconsin Investment Board is based upon filings on Schedule 13G
     made by the State of Wisconsin Investment Board.


                PROPOSAL 1:  ELECTION OF DIRECTORS

     The Company's Board of Directors currently consists of six persons, namely:
Leonard P. Shaykin (Chairman);  Sterling K. Ainsworth, Ph.D.; Patricia A. Pilia,
Ph.D.;  Arthur H. Hayes, Jr., M.D.; Mark B. Hacken; and Randolph C. Steer, M.D.,
Ph.D.  These directors are divided into three classes.  Drs. Pilia and Steer are
Class II directors,  with terms of office  expiring at the Annual  Meeting.  Dr.
Ainsworth and Mr. Hacken are Class III directors,  with terms of office expiring
at the Company's 1999 Annual Meeting of Stockholders.  Mr. Shaykin and Dr. Hayes
are Class I  directors,  with terms of office  expiring  at the  Company's  2000
Annual Meeting of Stockholders.

     Two Class II  directors  will be elected at the Annual  Meeting  for a term
expiring at the 2001 Annual  Meeting of  Stockholders.  Drs. Pilia and Steer are
nominated  for these board seats.  The nominees have agreed to serve if elected,
and  management  has no reason to believe that the nominees will be  unavailable
for service.  Shares represented by executed proxies will be voted, if authority
to do so is not withheld,  for the election of the nominees.  If either  nominee
should become  unavailable  for election due to an unexpected  occurrence,  such
shares  will be voted for the  election of a  substitute  nominee as the current
Board of Directors may propose.


Information concerning the Nominees

     Patricia A. Pilia, Ph.D., 49, a co-founder of the Company,  has served as a
director of the Company since its inception.  She was appointed Secretary of the
Company in November  1991,  Treasurer  of the  Company in October  1992 and Vice
President of BioResearch  and Toxicology in March 1993. In 1990, she co-founded,
with Dr. Ainsworth,  Pacific Biotechnology,  Inc. (a predecessor of the Company)
and served as its Vice  President  and Director of  Biotechnology.  From 1983 to
1991,  Dr.  Pilia was an  Assistant  Professor  of  Pathology  in the College of
Medicine and Dental Medicine and the College of Graduate  Studies at the Medical
University  of South  Carolina  ("MUSC").  Dr.  Pilia  served  as the  Assistant
Director of the MUSC Immunopathology  Diagnostic and Research  Laboratories from
1985 to 1991. Since 1984 she has been a consultant to industry on the design and
development  of biomedical  devices and treatment  modalities and the design and
performance of clinical trials.  Dr. Pilia received a Bachelor's  degree in 1970
from Boston University, a Master's degree in Immunology/Microbiology in 1978 and
a Doctoral  degree in Pathology in 1980 from MUSC. Dr. Pilia is engaged to marry
Dr. Ainsworth, a director and the Chief Executive Officer of the Company.

     Randolph C. Steer,  M.D.,  Ph.D., 48, was elected a director of the Company
by the  Board  in  February  1998.  He has  been an  independent  pharmaceutical
consultant  since 1989. Dr. Steer was Senior Vice President of Physicians  World
Communications Group from 1985 to 1989 and President and Chief Executive Officer
of Advanced  Therapeutics  Communications  International  from 1988 to 1989.  In
addition,  Dr. Steer served as Chairman of Advanced Therapeutics  Communications
International from 1985 to 1989. Dr. Steer was Medical Director of Ciba Consumer
Pharmaceuticals  from 1984 to 1985 and Associate Director of Medical Affairs for
Marion  Laboratories,  Inc., from 1982 to 1984. Dr. Steer received his M.D. from
Mayo  Medical  School  and his  Ph.D.  (Pathobiology)  from  the  University  of
Minnesota. Dr. Steer received his B.A. (Physiology) from University of Minnesota
in 1971.

         Management and the Board of Directors recommend a vote FOR each
                     nominee.

Directors Whose Terms Expire in 1999

     Sterling K. Ainsworth,  Ph.D., 56, a co-founder of the Company,  has served
as an executive  officer and  director of the Company  since its  inception,  as
Chief Executive Officer since November 1991 and as President since October 1992.
In 1990, he co-founded,  with Dr. Pilia, Pacific Biotechnology,  Inc. and served
as Chairman and President of such company until the  Company's  inception.  From
1972  until  1990,  Dr.  Ainsworth  held  various  levels of  professorships  of
Pathology  with  tenure in the  College  of  Medicine  and Dental  Medicine  and
Graduate  Studies at MUSC,  where he established,  developed and directed MUSC's
Immunopathology  Diagnostic  Laboratory.  Dr.  Ainsworth  received a  Bachelor's
degree from the University of Mississippi in 1963. He received a Master's degree
in Medical Microbiology in 1965 and a Doctoral degree in Medical Science in 1969
from  the  University  of   Mississippi   Medical   School.   He  completed  his
post-doctoral  fellowship  in the  Department  of Pathology  at Harvard  Medical
School from 1970 to 1972.  Dr.  Ainsworth  is engaged to marry Dr.  Pilia,  also
director and executive officer of the Company.

     Mark B. Hacken,  62, was appointed a director of the Company in March 1996.
Mr. Hacken served as President and Chief Executive  Officer of To Life!,  L.L.C.
(a privately held nutritional  supplement  company) from August 1996 to February
1998, and is a director of G.G.G. Inc. He was President of MBH International,  a
retail and health care consulting  company from March 1995 to August 1996. He is
the former  Chief  Executive  Officer  of FHP  International  Corporation  ("FHP
International"),  which was,  prior to its sale in 1997,  a $4 billion  HMO with
members in 11 states,  and its  operating  subsidiary,  FHP  Incorporated  ("FHP
Incorporated"),  a  diversified  health  care  services  company.  Prior  to his
appointment  to the Office of the Chief  Executive in October 1993, he served on
the boards of directors of FHP  International  and of FHP  Incorporated  for two
years and seven years, respectively.  He was co-founder and President of Elliott
Drugs,  and  President  of Drug  King  after  the firm was  acquired  from  DART
Industries. After Drug King was sold to Thrifty Corporation, he was instrumental
in converting them to the Thrifty Jr. drug store concept and he was President of
that  division.  Mr. Hacken  received a B.S. in Pharmacy from the  University of
Florida.


Directors Whose Terms Expire in 2000

     Leonard P.  Shaykin,  54, has served as  Chairman  of the Board  since June
1993. Pursuant to his Executive Agreement, Mr. Shaykin is not required to devote
more  than 20  hours in any  week  nor  more  than 80 hours in any  month to the
Company's  affairs.  In 1995, Mr. Shaykin founded  Shaykin & Company,  a private
investment holding firm. Prior to founding Shaykin & Company, Mr. Shaykin served
as a founding and a managing  partner in Adler & Shaykin,  an equity  investment
partnership  organized to sponsor leveraged buyouts.  Prior thereto, Mr. Shaykin
was  Vice  President,  director  and a member  of the  Investment  Committee  of
Citicorp Venture Capital, Ltd. and Citicorp Capital Investors, Inc., the venture
capital and equity investment subsidiaries of Citicorp and Citibank. Mr. Shaykin
is Chairman of the Board of Directors of Kimeragen,  Inc., a privately held gene
repair company; a director of Avigen, a public gene therapy company; Chairman of
the  Neuroblastoma  Foundation;  and  a  director  of  the  Jerusalem  Post,  an
English-language  offshore newspaper. Mr. Shaykin is also a governing trustee of
The Jackson  Laboratories,  a privately held genetic research  institute,  and a
trustee of the University of Chicago Graduate School of Business. Mr. Shaykin is
a graduate of the University of Chicago (B.A., M.A., M.B.A.).

     Arthur H. Hayes,  Jr., M.D., 63, was appointed a director of the Company in
March 1996. He is currently President and Chief Operating Officer of MediScience
Associates,  Inc. ("MediScience"),  a pharmaceutical consulting company and is a
Professor  of  Medicine  at New York  Medical  College  and  Pennsylvania  State
University  College of  Medicine.  From 1981 to 1983,  Dr.  Hayes  served as the
Commissioner of the FDA. From 1986 to 1991, he was President and Chief Executive
Officer of EM  Pharmaceuticals,  as well as a member of the board of  directors.
Dr.  Hayes  served as Provost & Dean at New York  Medical  College  from 1983 to
1986,  and served as the  Director of the  Institute  of Human Values in Medical
Ethics,  International  Health and Biomedical  Sciences,  the latter of which he
also served as  Chairman.  Dr. Hayes has held  several  posts with  Pennsylvania
State University which included Professor of Medicine and Pharmacology from 1977
to 1981,  Dean of  Admissions  from  1976 to 1979  and  Associate  Professor  of
Medicine and Pharmacology and Director of the Division of Clinical  Pharmacology
from 1972 to 1977.  Dr.  Hayes  currently  serves on the board of  directors  of
Myriad Genetics, Inc. (a genomic research and pharmaceutical  company),  Celgene
Corporation (a  pharmaceutical  company),  and Premier Research  Worldwide.  Dr.
Hayes  received  his M.D.  from Cornell  University  Medical  College,  and also
attended   Cornell's   Graduate  School  of  Medical  Sciences,   Department  of
Pharmacology.  He undertook  premedical studies,  and attended medical school at
Georgetown  University.  Dr. Hayes received his M.S.  (Philosophy,  Politics and
Economics) from Oxford University,  where he was a Rhodes Scholar,  and his A.B.
(Philosophy) from Santa Clara University in 1955.


Other Executive Officers

     The Company has the following  executive  officers in addition to those who
serve as directors:

     Gordon H. Link,  Jr.,  44, a certified  public  accountant  and a certified
management accountant,  joined the Company as Vice President,  Finance and Chief
Financial Officer in September 1993. Prior thereto, Mr. Link served concurrently
as  Corporate   Controller  of  Synergen,   Inc.  and  of  the   Syntex-Synergen
Neuroscience  Joint  Venture.  From February 1991 until April 1993, Mr. Link was
Treasurer  of Synergen  Development  Corporation.  From October 1983 through May
1990, Mr. Link practiced as a certified public accountant,  most recently in the
position of Audit  Manager  with  Deloitte & Touche.  He received  undergraduate
degrees  in  chemistry  from  Rensselaer  Polytechnic  Institute  in 1976 and in
accounting from Metropolitan State College in 1983.

     David L. Denny, 44, has served as Vice President, Operations of the Company
since September 1995,  except for a nine month period during 1997 when he served
as Vice  President,  Quality  Assurance.  From 1991 to 1993, Mr. Denny served as
Vice President of Operations for Somatogen, Inc. Prior thereto, Mr. Denny served
in manufacturing  and quality  assurance  capacities with Miles  Pharmaceutical,
Abbott  Laboratories  and  Kabi-Pharmacia.  He  received  a B.S.  in  Biological
Sciences from Tennessee  Technological  University in 1972 and attended graduate
school at the same institution from 1972 to 1974.

     James D.  McChesney,  Ph.D.,  58,  joined the Company as Vice  President of
Natural Products Chemistry in January 1996. From 1987 until June 1995, he served
as  Director  of  the  Research  Institute  of  Pharmaceutical  Sciences  at the
University  of  Mississippi,  specializing  in  natural  product  pharmaceutical
research and  development.  In July 1993, Dr. McChesney was named Frederick A.P.
Barnard   Distinguished   Professor  of   Pharmacognosy  at  the  University  of
Mississippi.  Dr.  McChesney  joined the School of Pharmacy at the University of
Mississippi in 1978 as Professor and Chair of the  Department of  Pharmacognosy.
After  graduating with honors from Iowa State  University in 1961 with a B.S. in
Chemical  Technology,  he earned  degrees  in  Botany  (M.A.  1964) and  Natural
Products Chemistry (Ph.D. 1965) at Indiana  University.  He has been a Fulbright
Lecturer  in  Brazil  and  a  Visiting   Professor  at  several  South  American
universities.

     William D. Fairbairn,  R.A.C, 59, was appointed Vice President,  Regulatory
Affairs  in  1996.  Prior  thereto,  he  was  a  consultant  to  NaPro  and  the
pharmaceutical  industry.  From 1988 to 1994 Mr. Fairbairn was Vice President of
Regulatory  Affairs  and  Compliance  at  Synergen,  Inc.  He  was  Director  of
Regulatory  Affairs  at  Allergan  Pharmaceuticals  where  he  also  held  other
positions  from 1963 to 1988. He has worked more 30 years in the  pharmaceutical
business with 20 years in  regulatory  affairs and the remainder in clinical and
preclinical  research.  Mr.  Fairbairn  received a B.S.  from  California  State
Polytechnic  University,  an M.A.  from  the  University  of  California  at Los
Angeles, and an M.B.A. from Pepperdine University.  From 1987 to 1993, he served
on the Board of Directors of the Regulatory Affairs  Professionals  Society.  In
1991  Mr.  Fairbairn   received  his  Certification  as  a  Regulatory   Affairs
Professional.


Board Meetings and Committees

     The Board of Directors  held twelve  meetings  during 1997,  including both
regularly scheduled and special meetings.

     The Board of Directors has established an Audit  Committee,  a Compensation
Committee  and a Strategic  Planning  Committee.  It does not have a  Nominating
Committee. The Audit Committee,  which consists of Mr. Hacken, Chairman, and Dr.
Steer,  meets  periodically with  representatives  of the Company's  independent
auditors and the  Company's  management to obtain an assessment of the Company's
financial  condition  and  results of  operations,  the results and scope of the
annual audit and other services provided by the Company's  independent auditors,
and  reports to the full Board of  Directors  with  respect  thereto.  The Audit
Committee,  then consisting of Mr. Hacken and a former  director,  met two times
during 1997. The Compensation Committee,  which consists of Dr. Hayes, Chairman,
Dr. Steer and Mr. Hacken,  meets  periodically to review and to recommend to the
full Board of Directors  compensation  arrangements  for senior  management  and
directors.   In  addition,   the  Compensation   Committee  is  responsible  for
administering  the  Company's  existing  stock option  plans.  The  Compensation
Committee, then consisting of two former directors, met three times during 1997.
The Strategic Planning Committee,  which currently consists of Mr. Shaykin,  Dr.
Ainsworth and Dr. Hayes,  meets  periodically to review the Company's  strategic
plans  in  connection  with  product   development  and  marketing,   regulatory
approvals,  clinical testing and other matters. The Strategic Planning Committee
did not meet during 1997. Each director  attended more than 75% of the aggregate
number of board and/or applicable committee meetings in 1997.

<PAGE>


Compensation of Executive Officers

     Executive Compensation

     The following  table sets forth  compensation  paid to the Named  Executive
Officers during the years indicated:


                    SUMMARY COMPENSATION TABLE
<TABLE>
<CAPTION>

                                  Annual Compensation                      Long-Term Compensation Awards
                                ------------------------    -----------------------------------------------------------
                                                                                              Securities Under-     All Other
Name and Principal                                                      Restricted Stock      lying Options         Compensa-
Position                Year    Salary ($)(1)   Bonus($)                      Awards($)          /SARs(#)           tion ($)(8)
- ------------------------------  -------------   --------                ----------------      -------------------   -----------
<S>                     <C>       <C>            <C>                            <C>            <C>                   <C>

Sterling K.             1997      $178,631          0                            0             100,000(2)(3)         $1,000
Ainsworth               1996      $159,000       $20,000                         0              50,000               $1,000
President and C.E.O.    1995      $152,077       $20,000                        $20,000         40,000                0

Leonard P. Shaykin      1997      $158,999          0                            0             100,000(2)(4)         $1,000
Chairman of the         1996      $159,000       $20,000                         0              50,000                0
Board                   1995      $152,077       $20,000                        $20,000        100,000                0

Patricia A. Pilia       1997      $127,972          0                            0              50,000(2)(5)         $1,000
Vice President,         1996      $121,900       $20,000                         0              25,000               $1,000
Secretary and           1995      $116,592       $15,000                        $15,000         20,000                0
Treasurer
Gordon H. Link, Jr.     1997      $119,005          0                            0              35,000(2)(6)         $1,000
Chief Financial         1996      $109,156       $13,370                         0              20,000               $1,000
Officer                 1995      $101,385       $10,000                        $10,000         10,000                0

James D. McChesney      1997      $138,098          0                            0              15,000(2)(7)         $1,000
Vice President,         1996      $101,538       $10,000                                        10,000                0
Natural Product         1995          0             0                                           25,000                0
Chemistry
</TABLE>

- -----------

     (1) In order for the Company to conserve cash,  each of the Named Executive
Officers agreed to defer a portion of his or her compensation payable subsequent
to  August  7,  1997.   Salary  for  1997  includes  the  following  amounts  of
compensation that has been so deferred: $7,404 for Dr. Ainsworth, $6,727 for Mr.
Shaykin, $5,711 for Dr. Pilia, $4,933 for Mr. Link and $4,933 for Dr. McChesney.

     (2) As more  fully  described  below,  in March  1998, as part of a plan to
restructure the Company's  outstanding options (the "Option Restructuring Plan")
the Company offered holders of options an opportunity to exchange options having
an exercise price above $3.00 (the "Covered Options") for new options. Employees
could elect to have their  Covered  Options  canceled  and  replacement  options
granted for 80% of the number of shares covered by the canceled  options.  These
replacement options were granted on March 27, 1998 and have an exercise price of
$1.81,  the last  sale  price of the  Common  Stock as  reported  by the  Nasdaq
National  Market  on the date of  grant.  The  replacement  options  granted  to
employees vest on the same schedule as the canceled options,  25% on each of the
first four anniversaries of the date of the replacement grant.

     (3) This  option to purchase 100,000  shares of Common Stock was granted to
Dr.  Ainsworth  in October  1997,  subject  to  stockholder  approval.  Upon Dr.
Ainsworth's  election to  participate  in the Option  Restructuring  Plan,  this
option  was  canceled,  and on  March  27,  1998,  Dr.  Ainsworth  was  issued a
replacement option to purchase 80,000 shares of Common Stock.

     (4) This option to purchase  100,000  shares of Common Stock was granted to
Mr. Shaykin in October 1997, subject to stockholder approval. Upon Mr. Shaykin's
election  to  participate  in the Option  Restructuring  Plan,  this  option was
canceled,  and on March 27, 1998, Mr. Shaykin was issued a replacement option to
purchase 80,000 shares of Common Stock.

    (5) This option to purchase 50,000 shares of Common Stock was granted to Dr.
Pilia in  October  1997,  subject  to  stockholder  approval.  Upon Dr.  Pilia's
election  to  participate  in the  Option  Restructuring  Plan this  option  was
canceled,  and on March 27, 1998,  Dr. Pilia was issued a replacement  option to
purchase 40,000 shares of Common Stock.

     (6) Includes an option to purchase 25,000 shares of Common Stock granted in
October 1997 and an option to purchase  10,000  shares of Common Stock which was
granted in June 1997, subject to stockholder approval.  Upon Mr. Link's election
to participate in the Option  Restructuring  Plan,  these options were canceled,
and on March 27, 1998,  Mr. Link was issued a  replacement  option to purchase a
total of 28,000 shares of Common Stock.

     (7) This  option to purchase 15,000  shares of Common  Stock was granted in
October 1997, subject to stockholder approval.  Upon Dr. McChesney's election to
participate in the Option  Restructuring Plan, this option was canceled,  and on
March 27, 1998, Dr. McChesney was issued a replacement option to purchase 12,000
shares of Common Stock.

     (8) Represents the Company's 401(k) plan matching contributions for each of
the Named Executive Officers.


     The  following  table sets forth each grant of options to  purchase  Common
Stock made  during  the year  ended  December  31,  1997 to the Named  Executive
Officers:



                OPTION GRANTS IN LAST FISCAL YEAR
<TABLE>
<CAPTION>

                                                                                                        Value at Assumed Annual
                                    Number of     % of Total                                             Rates of Stock Price
                                    Securities       Options                                                Appreciation for
                                    Underlying     Granted to     Exercise or Base                         Option Terms ($)(4)
                                    Options       Employees in    Price Per Share      Expiration
             Name                   Granted      Fiscal Year(2)        ($/sh)            Date(3)           5%             10%
                                    (#)(1)
- ----------------------------------------------------------------------------------------------------------------------------------
<S>                               <C>               <C>               <C>              <C>                <C>           <C>

Sterling K. Ainsworth             100,000(5)        16.32%            $8.313           10/20/07           $522,769      $1,324,798
Leonard P. Shaykin                100,000(6)        16.32%            $8.313           10/20/07           $522,769      $1,324,798
Patricia A. Pilia                 50,000(7)          8.16%            $8.313           10/20/07           $261,384        $662,399
Gordon H. Link, Jr.               10,000(8)          1.63%            $7.125            6/10/05            $34,019         $81,481
                                  25,000(9)          4.08%            $8.313           10/20/07           $130,692        $331,200
James D. McChesney                15,000(10)         2.45%            $8.313           10/20/07            $78,415        $198,720
</TABLE>

- -----------

     (1) Options become  exercisable at the rate of 25% of the shares subject to
the option one year after the date of grant and 25% of the shares subject to the
option each year thereafter.

     (2) Based on an  aggregate of 612,750  options  granted to employees of the
Company,  including  the Named  Executive  Officers,  in 1997.  

     (3) Options are subject to earlier  termination  upon death,  disability or
termination of employment.

     (4) The potential  realizable  value is calculated based on the term of the
option at its date of grant  assuming  that the stock price on the date of grant
appreciates at the indicated annual rate compounded annually for the entire term
of the option and that the option is  exercised  and sold on the last day of its
term for the appreciated stock price. No gain to the optionee is possible unless
the  stock  price  increases  over the  option  term,  which  will  benefit  all
stockholders.

     (5) This option to purchase  100,000  shares of Common Stock was granted to
Dr.  Ainsworth  in October  1997,  subject  to  stockholder  approval.  Upon Dr.
Ainsworth's  election to  participate  in the Option  Restructuring  Plan,  this
option  was  canceled,  and on  March  27,  1998,  Dr.  Ainsworth  was  issued a
replacement option to purchase 80,000 shares of Common Stock.

     (6) This  option to purchase 100,000  shares of Common Stock was granted to
Mr. Shaykin in October 1997, subject to stockholder approval. Upon Mr. Shaykin's
election  to  participate  in the Option  Restructuring  Plan,  this  option was
canceled,  and on March 27, 1998, Mr. Shaykin was issued a replacement option to
purchase 80,000 shares of Common Stock.

    (7) This option to purchase 50,000 shares of Common Stock was granted to Dr.
Pilia in  October  1997,  subject  to  stockholder  approval.  Upon Dr.  Pilia's
election  to  participate  in the Option  Restructuring  Plan,  this  option was
canceled,  and on March 27, 1998, Dr. Pilia's was issued a replacement option to
purchase 40,000 shares of Common Stock.

    (8) This option to purchase 10,000 shares of Common Stock was granted to Mr.
Link in June  1997.  Upon Mr.  Link's  election  to  participate  in the  Option
Restructuring  Plan,  this option was canceled,  and on March 27, 1998, Mr. Link
was issued a replacement option to purchase 8,000 shares of Common Stock.

    (9) This option to purchase 25,000 shares of Common Stock was granted to Mr.
Link in October 1997, subject to stockholder approval.  Upon Mr. Link's election
to participate in the Option  Restructuring Plan, this option was canceled,  and
on March 27, 1998, Mr. Link was issued a replacement  option to purchase  20,000
shares of Common Stock.

     (10) This option to purchase  15,000  shares of Common Stock was granted to
Dr.  McChesney  in October  1997,  subject  to  stockholder  approval.  Upon Dr.
McChesney's  election to  participate  in the Option  Restructuring  Plan,  this
option  was  canceled,  and on  March  27,  1998,  Dr.  McChesney  was  issued a
replacement option to purchase 12,000 shares of Common Stock.

<PAGE>


   The following table sets forth information concerning outstanding options
held by each of the Named Executive Officers as of December 31, 1997.

     AGGREGATED OPTION/SAR EXERCISES IN LAST FISCAL YEAR AND
                FISCAL YEAR-END OPTION/SAR VALUES
<TABLE>
<CAPTION>
                                            Number of Securities Underlying                        Value of Unexercised
                                        Unexercised Options/SARs at Fiscal Year          in-the-Money Options/SARs at Fiscal Year
                                                         End(#)                                          End($)(1)
           Name                                Exercisable/Unexercisable                         Exercisable/Unexercisable
- -----------------------------------  ----------------------------------------------  -----------------------------------------------
<S>                                             <C>                                                    <C>           

Sterling K. Ainsworth                           155,167 / 157,500(2)(3)                                $283,667 / $0
Leonard P. Shaykin                               62,500 / 187,500(2)(4)                                   $0 / $0
Patricia A. Pilia                                53,050 / 78,750(2)(5)                                 $85,100 / $0
Gordon H. Link, Jr.                              49,167 / 59,167(2)(6)                                $47,167 / $167
James D. McChesney                               15,000 / 35,000(2)(7)                                    $0 / $0
</TABLE>

- ----------

(1)Represents the difference between the option exercise price and the last
   sale price of the Common Stock as reported by the Nasdaq National Market on
   December 31, 1997 ($2.50), multiplied by the corresponding number of
   underlying shares.
(2)As more fully described below, in March 1998, as part of the Option
   Restructuring Plan the Company offered holders of options an opportunity to
   exchange Covered Options for new options. Employees could elect to have their
   Covered Options canceled and replacement options granted for 80% of the
   number of shares covered by the canceled options. These replacement options
   were granted on March 27, 1998 and have an exercise price of $1.81, the last
   sale price of the Common Stock as reported by the Nasdaq National Market on
   the date of grant. The replacement options granted to employees vest on the
   same schedule as the canceled options, 25% on each of the first four
   anniversaries of the date of the replacement grant.
(3)A total of 190,000 options held by Dr. Ainsworth on December 31, 1997 were
   Covered Options, and, upon Dr. Ainsworth's election to participate in the
   Option Restructuring Plan, these 190,000 options were canceled and
   replacement options to purchase 152,000 shares of Common Stock were granted
   to Dr. Ainsworth.
(4)All 250,000 options held by Mr. Shaykin on December 31, 1997 were Covered
   Options, and, upon Mr. Shaykin's election to participate in the Option
   Restructuring Plan, these 250,000 options were canceled and replacement
   options to purchase a total of 200,000 shares of Common Stock were granted to
   Mr. Shaykin.
(5)A total of 95,000 options held by Dr. Pilia on December 31, 1997 were
   Covered Options, and, upon Dr. Pilia's election to participate in the Option
   Restructuring Plan, these 95,000 options were canceled and replacement
   options to purchase a total of 76,000 shares of Common Stock were granted to
   Dr. Pilia.
(6)A total of 75,000 options held by Mr. Link on December 31, 1997 were Covered
   Options, and, upon Mr. Link's election to participate in the Option
   Restructuring Plan, these 75,000 options were canceled and replacement
   options to purchase a total of 60,000 shares of Common Stock were granted to
   Mr. Link.
(7)All 50,000 options held by Dr. McChesney were Covered Options, and, upon Dr.
   McChesney's election to participate in the Option Restructuring Plan, these
   50,000 options were canceled and replacement options to purchase a total of
   40,000 shares of Common Stock were granted to Dr. McChesney.


Compensation of Directors

     Pursuant to the 1994 Plan, non-employee directors automatically are granted
each  year,  on the  date  of the  Company's  annual  meeting  of  stockholders,
non-qualified  options to purchase  10,000 shares of Common Stock.  In addition,
any  non-employee  director who is first  appointed or elected  other than at an
annual meeting of stockholders  automatically  receives non-qualified options to
purchase  10,000 shares of Common Stock upon such  appointment or election.  The
1994 Plan also  provides for  automatic  annual  grants of  non-qualified  stock
options to purchase  10,000  shares of Common  Stock to  directors  who serve as
chairs of the Audit, Compensation and Strategic Planning Committees of the Board
of Directors.  In addition, the 1994 Plan permits the discretionary grant by the
Board of Directors of  non-qualified  options to  non-employee  directors  under
certain  circumstances.  All such options are  exercisable  at an exercise price
equal to the fair market  value of the Common Stock on the date of grant and are
subject to certain  vesting  schedules.  Upon the  election by Dr. Hayes and Mr.
Hacken to participate in the Company's  Option  Restructuring  Plan,  options to
purchase 25,000 shares of Common Stock held by Dr. Hayes and options to purchase
45,000 shares of Common Stock held by Mr.  Hacken were canceled and  replacement
options to purchase  20,000 and 36,000  shares were granted to Dr. Hayes and Mr.
Hacken, respectively.

     Directors are  reimbursed  for their costs  incurred in attending  Board of
Directors meetings.

     The Company and  MediScience  are parties to a  consulting  agreement  (the
"MediScience Agreement") whereby Dr. Hayes, who is President and Chief Operating
Officer of  MediScience,  provides  the Company  with  consulting  services in a
variety of areas,  including clinical research planning,  strategic  positioning
and regulatory  guidance.  The Company makes  quarterly  payments to MediScience
under the  MediScience  Agreement  of $12,500 for such  services.  Dr.  Hayes is
obligated  to  provide  consulting  services  under  the  MediScience  Agreement
indefinitely,  but the  MediScience  Agreement is  terminable  by the Company or
MediScience at any time with 90 days prior notice.

     Dr. Steer, who was appointed as a director of the Company in February 1998,
provides consulting services as part of the Company's  Scientific Advisory Board
and under a separate consulting  agreement.  The Company annually grants to each
member of the  Scientific  Advisory  Board an option to purchase 1,000 shares of
Common Stock and pays its members $1,000 per day plus expenses for attendance at
meetings.  In addition,  Dr. Steer provides  consulting  services to the Company
under a separate consulting agreement. During 1997 Dr. Steer was paid $12,300 by
the Company for these consulting services.


Employment Agreements

     The Company  entered into an Employment and Executive  Stock Agreement with
each of Mr.  Shaykin and Drs.  Ainsworth  and Pilia  (collectively,  the "Senior
Executives"),  effective as of June 7, 1993, and amended and restated  effective
as of May 31, 1994 (collectively,  the "Executive  Agreements").  Each Executive
Agreement provides for an initial five-year employment term that expires June 7,
1998 (the  "Initial  Term"),  and is renewable  each year  thereafter  (each,  a
"Renewal  Term")  unless either party gives notice of  termination  to the other
party at least 180 days prior to the  commencement  of any Renewal Term. No such
notice  of  termination  has been  given by any of the  Senior  Executives.  The
Executive  Agreements  provide for annual base salaries for Mr. Shaykin and Drs.
Ainsworth and Pilia of $150,000, $150,000, and $115,000 respectively.  Under the
Executive Agreements, the Senior Executives may be granted annual bonuses at the
discretion of the Board's  Compensation  Committee.  Mr.  Shaykin is a part-time
employee of the Company,  and is not required  under his Executive  Agreement to
spend  more  than 20 hours in any week or 80 hours  per  month on the  Company's
affairs.

     Each Executive Agreement provides for certain benefits if, prior to the end
of the Initial Term or any Renewal  Term,  a Senior  Executive's  employment  is
terminated  either  by the  Company  other  than for Cause  (as  defined  in the
Executive  Agreements) or by the Senior Executive for Good Reason (as defined in
the Executive  Agreements).  In general, each Senior Executive would be entitled
to (i) a continuance of his or her respective  salary and bonus, if any, through
the end of the Initial  Term (but in no event for longer than three years in the
case of Mr. Shaykin) or the then-current  Renewal Term, if applicable,  and (ii)
health and welfare benefits as in effect  immediately prior to termination for a
maximum of 18 months  following  termination.  The foregoing  benefits  would be
limited by the amount  deductible  for income tax  purposes  under the  Internal
Revenue Code of 1986, as amended (the "Code").

     The Executive Agreements also contain provisions (i) prohibiting disclosure
of confidential information, (ii) granting to the Company rights to intellectual
property  developed  by the  Senior  Executives  that  relate  to the  Company's
business  or  developed  in the course of  employment  with the Company (or that
otherwise  relate in any way to health care or  pharmaceuticals,  in the case of
Drs.  Ainsworth and Pilia) and (iii)  prohibiting  competition  with the Company
during and for five years after the Senior Executive's employment.

     Under his Executive  Agreement,  Mr.  Shaykin  acquired  150,428  shares of
Common Stock (the  "Executive  Stock").  The purchase  price for such shares was
$1.50 per share and was represented by a promissory note in favor of the Company
(the "Executive Note"). Commencing in 1995, Mr. Shaykin became able to repay all
or part of the  outstanding  principal  and  interest on his  Executive  Note by
remitting to the Company  shares of his Executive  Stock,  to be valued for such
purposes in an amount equal to the average of the last  reported  sales price of
the Common Stock for the five trading days prior to remittance multiplied by the
number of shares  remitted.  During 1997, Mr. Shaykin  remitted shares of Common
Stock to the Company in exchange for  extinguishment  of the debt represented by
his Executive Note. See " Certain Relationships and Related Transactions."


Section 16(a) Beneficial Ownership Reporting Compliance

     Under Section 16(a) of the Securities Exchange Act of 1934, as amended (the
"Exchange  Act"),  the  Company's  directors  and certain of its  officers,  and
persons holding more than ten percent of the Company's Common Stock are required
to file forms reporting their beneficial ownership of the Company's Common Stock
and  subsequent  changes in that  ownership  with the  Securities  and  Exchange
Commission  (the "SEC").  Such persons are also  required to furnish the Company
copies of forms so filed.  Based  solely  upon a review of copies of such  forms
filed with the  Company,  Mr.  Bewkes,  a former  director  of the  Company  who
resigned  in  December  1997,  and Dr.  Hayes were late in filing one Form 5, on
which they reported one  transaction,  and Dr. Steer was late in filing one Form
3. No other  directors or officers were late in filing any reports on Forms 3, 4
or 5.


Compensation Committee Interlocks and Insider Participation

     Currently,  the Compensation Committee consists of Drs. Steer and Hayes and
Mr.  Hacken.  From January 1994 to March 1998,  Richard C.  Pfenniger,  Jr. also
served on the  Compensation  Committee.  Mr. Pfenniger served as Chief Operating
Officer of IVAX and held various  other  executive  positions  with certain IVAX
subsidiaries during 1997. See " Certain Relationships and Related Transactions."


Compensation Committee Report on Executive Compensation

     The report of the  Compensation  Committee of the Board of  Directors  (the
"Committee")  shall not be  deemed  incorporated  by  reference  by any  general
statement  incorporating  by  reference  this report  into any filing  under the
Securities Act of 1933, as amended (the "Securities Act"), or under the Exchange
Act,  except to the  extent  that the  Company  specifically  incorporates  this
information  by  reference,  and shall not  otherwise be deemed filed under such
Acts.

     Goals.  The  Committee  implements  the  Company's  executive  compensation
policies.  The Company is  committed  to executive  compensation  policies  that
promote and support the  Company's  goals and that inspire  executives to make a
significant  contribution  to the  financial  performance  of the  Company.  The
Company's  overall  compensation  philosophy  for  executive  officers  has  the
following  objectives:  (i) the attraction and retention of qualified  personnel
whose  participation is important to the short-term and long-term success of the
Company;  and (ii) the creation of a mutual interest between executive  officers
and  stockholders  that  permits  executive  officers  to share in the risks and
rewards of strategic decision-making.

     The Company has established its executive  compensation  policies using the
above  objectives as its  foundation.  The  Committee's  current  practice is to
review the  compensation of the five highest paid employees of the Company,  all
employees earning at least $75,000 per year and any other executive  officers of
the Company that are named in any required disclosure documents under applicable
securities   laws.  The  Committee  also  administers  all  annual  bonuses  and
equity-based  incentive  compensation  including  grants  of stock  options  and
restricted  stock. The following  describes the three primary  components of the
Company's current executive compensation program.

     Base  Salary.  For fiscal year 1997,  the base salary  compensation  of the
Company's  Chief  Executive  Officer,  Dr.  Ainsworth,  and certain other senior
executives,  was primarily  determined by such officers'  employment  agreements
with the Company.  The  Compensation  Committee  believes  that the current base
salaries of the Company's  executive  officers are  justified by such  officers'
performance  and value to the  Company,  and take into  account  the  market and
competitive conditions affecting the demand for the skills and expertise of such
executive officers.

     Annual Bonus.  Due to the  Company's  financial  position,  no bonuses were
granted to the Company's executive officers during fiscal year 1997.


<PAGE>


     Equity-based  Incentives.  The Company considers equity-based incentives to
be an integral part of executive  compensation.  The Committee believes that the
grant of restricted stock awards, stock options and other awards pursuant to the
1993  Stock  Option  Plan and 1994 Plan has been,  and will  continue  to be, an
effective  method for the creation of a mutual  interest  between the  Company's
employees  and the  Company's  stockholders.  During  1997,  stock  options were
granted to seven  executive  officers.  These  grants  were  recommended  to the
Committee by the Chairman of the Board and the President.  Factors considered in
the grant of restricted  stock awards and stock options include  recommendations
made to the  Committee  by the  Chairman of the Board and the  President  of the
Company  and  the  Committee's  own  subjective  evaluation  of  the  individual
executive's  performance and the performance of the Company, taking into account
the goal and overall  compensation  philosophy stated above. The recommendations
of  such  grants  to  the  Committee  and  the  Committee's   approval  of  such
recommendations were not based on any specific formulas.

     For  fiscal  year  1997  the  total  compensation  (including  bonuses  and
equity-based   incentives)  of  the  Company's  Chief  Executive  Officer,   Dr.
Ainsworth,  and  other  senior  executives,   was  assessed  in  light  of  such
executives'  performance  and the  progress of the Company.  Factors  taken into
account  included  various  achievements  by  the  Company  in  scaling  up  its
manufacturing activities, securing raw material resources, and other steps taken
by the Company to support the  manufacture,  registration,  and marketing of the
Company's primary product, paclitaxel.

     On March 25, 1998 the  Compensation  Committee  reviewed  the status of the
Company's  outstanding options. The Compensation  Committee determined that as a
result  of the  drop in the  value  of the  Common  Stock at the end of 1997 and
beginning  of 1998,  which was the  result of  regulatory  issues not within the
control of the grantees,  the existing  options did not effectively  serve their
purpose of helping to retain directors,  officers, employees and consultants and
to closely  align the  interests of these  groups with those of the Company.  In
order to renew these  incentives,  on March 25, 1998 the Compensation  Committee
approved  and  recommended  to the Board of Directors  the Option  Restructuring
Plan. The Option  Restructuring  Plan gave holders of the Company's  options the
opportunity to surrender their existing  options having a price above $3.00 (the
"Covered Options") in exchange for replacement options issued on March 27, 1998.
If  the  holder  of  Covered   Options  chose  to   participate  in  the  Option
Restructuring  Plan,  such  holder was  required  to give up 20% or 50% of their
Covered  Options,  depending  upon the  option  holder's  relationship  with the
Company,  and the  replacement  options  were  granted as of March 27,  with new
vesting  beginning  as of that date.  In addition,  for Covered  Options held by
former  directors  and former  consultants,  the period during which the options
could be exercised was shortened.


                                   COMPENSATION COMMITTEE

                                   Dr. Arthur H. Hayes, Jr.
                                   Dr. Randolph C. Steer
                                   Mark B. Hacken


Stock Price Performance Graph

     The Stock  Price  Performance  Graph  shall not be deemed  incorporated  by
reference by any general  statement  incorporating by reference this report into
any filing under the  Securities  Act, or under the Exchange Act,  except to the
extent that the Company specifically incorporates this information by reference,
and shall not otherwise be deemed filed under such Acts.

     The graph below  compares the  cumulative  return of the  Company's  Common
Stock  against the Total  Return Index for the NASDAQ  Market  (U.S.) and a peer
group which is comprised of the  companies  listed on the NASDAQ  Pharmaceutical
Stock Index. The cumulative return presented is based upon an initial investment
of $100 over the period August 1, 1994 (the date of the Company's initial public
offering) through December 31, 1997. The stock price performance on the graph is
not necessarily an indicator of future price performance.  The cumulative return
of the Company's Common Stock is based upon its initial public offering price of
$5.00 and the last  reported  sale price of the Common  Stock as reported on the
Nasdaq National Market System on December 31, 1997, the last trading day of 1997
($2.50). The indices assume the reinvestment of all dividends.

[graph appears here]
<TABLE>
<CAPTION>

                        August 1,    December 30,     December 29,   December 31,   December 31,
                         1994          1994             1995           1996           1997
<S>                      <C>         <C>              <C>            <C>             <C>

NaPro (NPRO)             $100        $120.00          $187.50        $212.50         $50.00
NASDAQ Market (U.S.)     $100        $104.38          $147.63        $181.55         $222.80
Peer Group
(NASDAQ Pharmaceutical   $100        $102.46          $187.40        $188.01         $194.16
Index)
</TABLE>



Certain Relationships and Related Transactions

     In June 1993,  the Company  entered  into a strategic  alliance  (the "IVAX
Agreement")  with  BNP,  a  subsidiary  of  IVAX,  one  of the  largest  generic
pharmaceutical  companies  in the United  States,  which  provided  for  certain
exclusive and non-exclusive  rights for IVAX to develop and market the Company's
paclitaxel.  During  1997,  the  Company's  sales  of  paclitaxel  to IVAX  were
$2,275,000,  or 60% of the Company's  revenues  during such period.  Until April
1998,  IVAX,  through D&N,  beneficially  owned  1,126,398  shares of the Common
Stock,   representing   beneficial   ownership  of  approximately  7.6%  of  the
outstanding Common Stock as of the Record Date.

     On  March  20,  1998,  NaPro  and  IVAX  entered  into  an  agreement  (the
"Termination  Agreement") terminating the IVAX Agreement.  Under the Termination
Agreement, NaPro is obligated to sell a fixed quantity of paclitaxel to IVAX, at
a fixed  price,  in  installments  with the final  installment  due in the first
quarter  of  1999.  In  addition,   the  Termination  Agreement  grants  IVAX  a
royalty-free,  limited, non-exclusive license for one of NaPro's pending patents
(the "Pending  Patent") in the United  States,  Europe,  and certain other world
markets.  As  consideration  for  this  licence,   NaPro  received   $6,070,000,
$2,000,000  of which  was  placed  in  escrow  to be  released  in  installments
corresponding  to delivery of  paclitaxel to IVAX,  and 1,126,398  shares of its
Common Stock formerly beneficially owned by IVAX. In addition, NaPro received an
additional  $3,750,000  based upon issuance of the Pending  Patent in the United
States,  and IVAX has agreed to pay the Company  $2,610,000 upon issuance of the
Pending Patent in the European Patent Office, subject to certain limitations. In
connection with the Termination  Agreement,  Richard C. Pfenniger,  Jr. resigned
from the NaPro Board of Directors.  Mr.  Pfenniger,  who served as a director of
the Company from June 1993 until March 1998,  served as Chief Operating  Officer
of IVAX from April 1994 until March 1997.

     On the same day the Termination  Agreement was executed,  the Company, IVAX
and Mr. Shaykin entered into an agreement  relating to a warrant (the "Warrant")
to purchase  111,111  shares of Common Stock at an exercise  price of $0.075 per
share.  Mr.  Shaykin  acquired  the Warrant  from IVAX in 1996.  Pursuant to the
agreement,  Mr. Shaykin paid $100,000 to IVAX and IVAX forgave the  indebtedness
represented  by a promissory  note in the principal  amount of $944,443 that had
represented  the  original  purchase  price of the  Warrant by Mr.  Shaykin.  In
exchange for remission of the Warrant to the Company by Mr. Shaykin, the Company
agreed to indemnify IVAX for any loss associated with such transaction.

     On January 27, 1997, Mr.  Shaykin  remitted to the Company 74,550 shares of
Common  Stock  in  payment  of the debt  represented  by his  Executive  Note of
$989,640.72  owed to the Company by Mr.  Shaykin.  This  payment was effected in
accordance with the terms of Mr. Shaykin's Executive Agreement with the Company.
See "  Employment  Agreements."  The Common Stock was valued for such purpose at
$13.275 per share,  an amount  equal to the average of the last  reported  sales
price of the Common Stock for the five trading days prior to the remittance,  in
accordance with the provisions of the Executive Agreement.

     Vaughn D.  Bryson,  a director of the Company  until  December  1997,  is a
principal of Life Science Advisors  ("LSA"),  a health care consulting firm that
was party to a consulting  agreement (the "LSA Agreement")  whereby LSA provided
consulting services to the Company in the area of pharmaceutical  development in
1997. The Company made payments to LSA under the LSA Agreement in the amounts of
$1,800 per eight-hour  person day ($225 per person hour) for the services of the
principals of LSA and $1,500 per eight-hour person day ($187.50 per person hour)
for the  services of the  associates  of LSA. In  addition,  LSA  received  1500
options for each eight-hour person day of service provided by the principals and
600 options for each eight-hour person day of services provided by associates of
LSA. These options have an exercise price of $7.25 and have a term of ten years.
LSA earned and was granted 49,785 options under the LSA Agreement,  of which Mr.
Bryson was granted  15,162  options The LSA Agreement was  terminated in January
1998.  As part of the Option  Restructuring  Plan that the Company  initiated in
March 1998,  the members and  associates  of LSA were given the  opportunity  to
surrender  the options that had been granted to them in exchange for new options
for 50% fewer  shares of Common  Stock at an exercise  price of $1.81,  the fair
market  value of the Common  Stock on March 27,  1998.  Each of the  members and
associates of LSA elected to participate in the Option  Restructuring Plan. As a
result,  the members and  associates of LSA  surrendered  the options for 49,785
shares of Common  Stock in  exchange  for  options to purchase a total of 24,893
shares of Common Stock.


PROPOSAL 2:  APPROVAL OF THE ISSUANCE OF 20% OR MORE OF THE OUTSTANDING
   COMMON STOCK AT DISCOUNTS OF UP TO 10% FROM ITS MARKET VALUE
                       AS OF CERTAIN DATES

Background

     In June and December 1997, the Company issued the Convertible Notes and the
Convertible  Preferred  Stock,  respectively.  The  Convertible  Notes  and  the
Convertible Preferred Stock are referred to as the "Convertible Securities." The
conversion  price for each was fixed at $10.00 per share  through  the 119th day
after initial issuance,  but thereafter became a discount from the trading price
of the Common  Stock.  On the trading day  immediately  prior to issuance of the
Convertible  Notes,  the last  reported  sales price of the Common  Stock on the
Nasdaq  National  Market was $9.25 and on the trading day  immediately  prior to
issuance of the  Convertible  Preferred Stock was $6.50. At the time of issuance
of the  Convertible  Securities,  the trading  price of the Common Stock had not
been below $6.25 for at least two years. Nasdaq Stock Market Rule 4460(i), which
is  applicable  to issuers whose  securities  are listed on the Nasdaq  National
Market (the "Nasdaq Rule"),  requires stockholder approval of transactions other
than a public  offering  involving  the sale or  issuance  of  common  stock (or
securities  convertible  into or  exercisable  for common stock) equal to 20% or
more of the common  stock or voting power  outstanding  before the issuance at a
price  less  than  the  greater  of book or  market  value.  Given  the  initial
conversion  price of the  Convertible  Securities  and the then current  trading
price of the Common Stock, its was not necessary to obtain stockholder  approval
of these  transactions.  The conversion  right of the holders of the Convertible
Securities was structured so that each transaction  would comply with the Nasdaq
Rule by limiting  the number of shares of Common Stock that could be issued upon
conversion.  If the trading  price of the Common Stock  declined to a level such
that a portion of the Convertible  Notes and Convertible  Preferred Stock became
inconvertible as a result such  limitation,  at the option of the holders of the
Convertible  Securities  the Company  would be obligated to redeem for cash that
portion of the Convertible Securities that could not be converted because of the
limitation  unless  and until  the  Company  obtained  stockholder  approval  as
contemplated by the Nasdaq Rule to permit the issuance of shares of Common Stock
in  accordance  with the  original  terms  of the  instruments.  Such a  decline
occurred  in December  1997 and  January  1998.  As a result,  certain  material
provisions relating to the Convertible Notes and the Convertible Preferred Stock
were  amended to, among other  things,  suspend such  redemption  right  pending
approval of this Proposal. See " Terms of the Convertible Securities The January
Amendments" and " The March  Amendments." The amendments  (except those changing
the  conversion  price and  lowering the  exercise  price of warrants  issued in
connection with the original issuance of the Convertible  Securities)  terminate
if the  stockholder  approval sought by this Proposal 2 has not been received by
June 1, 1998.

     The Board of Directors has  determined  that  authorizing  under the Nasdaq
Rule the issuance of 20% or more of the outstanding Common Stock or voting power
at  discounts  of up to 10% from its  market  value as of  certain  dates to the
holders of the Convertible  Securities is advisable and in the best interests of
the  Company and its  stockholders  and  recommends  adoption of Proposal 2. The
Company and the holders of the Convertible  Notes and the Convertible  Preferred
Stock are party to agreements dated January 28, 1998 (the "January  Amendments")
that require the Company to seek stockholder approval of such issuance and of an
amendment to the Company's Certificate of Incorporation increasing the number of
authorized  shares  as  reflected  by  Proposal  3.  If such  approvals  are not
obtained,  the  January  Amendments  terminate  except  for  certain  provisions
favorable to the holders of the Convertible Securities.

     As of April 20, 1998, approximately $7.7 million in principal amount of the
Convertible   Notes  and  4,615  shares  of  the  Convertible   Preferred  Stock
(representing  approximately $4.6 million of initial liquidation value) remained
outstanding.  Based upon the conversion price applicable as of such date to each
and without regard to the limitations on issuance of Common Stock imposed by the
Nasdaq Rule, an aggregate of 4,901,537  shares of Common Stock would be issuable
upon  conversion of such  Convertible  Securities.  If Proposals 2 and 3 are not
approved by stockholders by June 1, 1998, and assuming no additional  conversion
of  Convertible  Securities  and no change  in the  conversion  price  from that
effective on April 20, 1998, (i) the holder of the  Convertible  Preferred Stock
would be  entitled  to  require  the  Company  to redeem  up to 1,359  shares of
Convertible  Preferred Stock for an aggregate  redemption price of approximately
$1,563,000, including any applicable redemption premium, and (ii) the holders of
the  Convertible  Notes will be  entitled to require the Company to redeem up to
$7,158,000 principal amount of the Convertible Notes for an aggregate redemption
price of approximately $8,748,000, including any applicable redemption premium.


Description of the Proposal

     The Nasdaq  Rule  provides  that a company  with  securities  listed on the
Nasdaq National Market must obtain stockholder approval of a sale or issuance by
the company of common stock (or securities  convertible  into or exercisable for
common stock) equal to 20 % or more of the common stock outstanding prior to the
issuance if the sale price for such  securities is less than the greater of book
or market  value.  Approval of this proposal by  stockholders  would satisfy the
stockholder  approval  requirements  of the Nasdaq Rule for both the Convertible
Notes and the Convertible  Preferred Stock and allow the Company to issue 20% or
more of the Company's Common Stock outstanding to the holders of the Convertible
Notes and the holder of the Convertible  Preferred  Stock, in each case upon the
conversion  of  those  securities.   Approval  of  Proposals  2  and  3  by  the
stockholders is intended to prevent severe depletion of the Company's  available
cash upon  redemption of the  Convertible  Notes and the  Convertible  Preferred
Stock.


Terms of the Convertible Securities

     The terms of the  Convertible  Securities  are very  complex.  Any  summary
thereof  will be general in nature and must be  qualified  by  reference  to the
actual agreements  attached as exhibits to the Company's Current Reports on Form
8-K referred to below.  Stockholders  desiring a more complete  understanding of
the  Convertible  Securities  and  their  operation  are  urged to refer to such
exhibits.

     The Convertible Notes. On June 4, 1997 NaPro privately issued $10.3 million
of  Convertible  Notes.  The  Convertible  Notes  mature  in June  2000 and bear
interest at a rate of 5% per year.  Interest may be paid in Common Stock or cash
at the  Company's  option.  Beginning  120  days  after  initial  issuance,  the
Convertible Notes were convertible into Common Stock at discounts  (ranging from
5% to 10%) from the market price of the Common Stock  during  specified  periods
prior to the conversion.  In the event that, on five days during a period of ten
consecutive trading days,  conversion of the outstanding principal amount of the
Convertible  Notes would  result in the  issuance  of Common  Stock in an amount
exceeding  the amount  allowable  under the Nasdaq Rule (a "Note  Maximum  Share
Amount  Inconvertibility"),  the  Company  could be  required  by holders of the
Convertible  Notes to redeem for cash that portion of the Convertible Notes that
may not be converted,  such  redemption to be at a premium  (ranging from 11% to
13% depending on the time of such  redemption)  from the principal amount of the
Convertible  Note to be redeemed.  A Note Maximum Share Amount  Inconvertibility
occurred in January 1998. At that time,  the Company  redeemed  $397,000 in note
principal  and  paid  $53,000  premium  and  interest  in  connection  with  the
redemption.

     The Convertible Preferred Stock. On December 8, 1997 NaPro privately issued
the  Convertible  Preferred Stock for an aggregate  consideration  of $5 million
(5,000  shares at $1,000 per share).  The  Convertible  Preferred  Stock accrues
dividends  at 5% per annum  payable  quarterly  in  Common  Stock or cash at the
Company's  option.  Beginning 120 days after initial  issuance,  the Convertible
Preferred  Stock were  convertible  into Common Stock at a 5% discount  from the
average of the two lowest closing  trading prices to occur during the 15 trading
days immediately  preceding the conversion date. In the event that, on five days
during a period of ten consecutive  trading days,  conversion of the outstanding
Convertible  Preferred  Stock would result in the issuance of Common Stock in an
amount which would exceed the amount  allowable  under the Nasdaq Rule (a "Stock
Maximum  Share Amount  Inconvertibility"),  the Company could be required by the
holder of the Convertible Preferred Stock to redeem for cash that portion of the
Convertible Preferred Stock that may not be converted,  such redemption to be at
a 15% premium.

     The January Amendments. As a result of substantial decreases in the trading
price of the Common Stock during  December 1997 and January 1998, a Note Maximum
Share Amount  Inconvertibility  occurred for the Convertible  Notes, and a Stock
Maximum Share Amount  Inconvertibility  would have occurred for the  Convertible
Preferred  Stock if the trading  price of the Common  Stock  remained at January
levels.  The Company entered into the January  Amendments in order to (i) obtain
relief from the redemption obligations,  (ii) provide a ceiling on the amount of
Common Stock which may be issued to holders of the Convertible  Securities prior
to January 1, 1999 and the  potential  dilution of the Common  Stock which would
result and (iii) give the  Company  the  opportunity  to redeem the  Convertible
Securities  for  cash  at a 30%  premium  in  the  event  the  Company  obtained
sufficient funds. The January  Amendments were filed with the SEC as exhibits to
the  Company's  Current  Report on Form 8-K dated  January  28,  1998,  to which
reference  is  hereby  made.  Under  the  January  Amendments,  holders  of  the
Convertible  Securities agreed to waive their right to require redemption of the
Convertible   Securities   due  to  a  Note  or  Stock   Maximum   Share  Amount
Inconvertibility  until  December  31,  1998,  so  long  as  the  Company  is in
compliance with its  obligations to holders of the  Convertible  Preferred Stock
and the Convertible  Notes and Proposals 2 and 3 are approved by stockholders by
June 1, 1998. In addition,  the January  Amendments set a limit on the principal
amount of the Convertible  Notes which may be converted into Common Stock and on
the number of shares of Common Stock which may be issued upon  conversion of the
Convertible  Preferred  Stock prior to December 31, 1998. No limitation  applies
after such date. The January  Amendments also  established a maximum  conversion
price for the Convertible  Securities based upon the trading price of the Common
Stock  prior to March 1 and June 1, 1998.  Based on the  trading  price prior to
March 1, 1998, the maximum  conversion price of Convertible  Securities will not
exceed $1.92385 per share.

     Under the January  Amendments,  the Company agreed,  among other things, to
(i) seek  stockholder  approval of an amendment to the Company's  Certificate of
Incorporation  which  would  increase  the  number of  shares  of  Common  Stock
authorized  for issuance from  19,000,000  shares to 30,000,000  shares and (ii)
seek  stockholder  approval of the issuance by the Company of 20% or more of the
Common Stock  outstanding on December 8, 1997 to the holders of the  Convertible
Preferred  Stock and  stockholder  approval of issuance by the Company of 20% or
more of the  Common  Stock  outstanding  on June 4, 1997 to the  holders  of the
Convertible Notes (together the "Required Proposals"). See "Proposal 3: Approval
of  an  Amendment  to  the  Company's  Certificate  of  Incorporation."  If  the
stockholders approve the amendment to the Company's Certificate of Incorporation
to increase the number of shares  authorized  for issuance to 30,000,000  shares
but do not  approve  Proposal  2, the  Company is required to seek waiver by the
Nasdaq Stock Market of the Nasdaq Rule.

     The March  Amendments.  The  Company  and the  holders  of the  Convertible
Securities  agreed to further amend the  Convertible  Securities on March 20 and
March 31, 1998 (the "March Amendments").  Pursuant to the March Amendments,  the
premium for optional redemption by the Company of the Convertible Securities was
reduced from 30% to 10% through about July 29, 1998. The March  Amendments  were
filed with the SEC as exhibits to the Company's Current Report on Form 8-K dated
March 20, 1998, to which reference is hereby made.

     As a result of the January and March  Amendments,  were the Company to have
the cash available to do so, it could redeem the Convertible Securities at a 10%
premium  though  about July 29, 1998 and at a 30% premium  through  December 31,
1998.  During such periods the number of shares of Common Stock  issuable to the
holders of the  Convertible  Securities  is limited to 450,000 per month.  After
December 31, 1998, the holders of the  Convertible  Securities  would be able to
convert the Convertible  Securities into Common Stock without  limitation at the
then  applicable  conversion  price,  which would not exceed  $1.9235 per share.
There can be no  assurance  that the Company will ever have  sufficient  cash to
redeem any outstanding Convertible Securities.


Reasons for Proposal

     The Board of Directors of the Company  believes that the termination of the
January  Amendments and resulting  reinstatement  of the right of the holders of
the Convertible  Preferred Stock and Convertible Notes to require the Company to
redeem their  Convertible  Securities has the potential to severely diminish the
Company's existing working capital. As a result, the Board of Directors believes
it is in the best  interest of the  stockholders  to approve  this  Proposal and
Proposal 3 as described in this Proxy Statement.  If stockholder approval of the
Required  Proposals is not received by June 1, 1998, the January Amendments will
terminate,  subject to certain limited exceptions, and the Company will lose its
benefits associated with those amendments.


Vote Required for Approval of the Proposal

     Under the Nasdaq Rule, approval of Proposal 2 requires the affirmative vote
of a majority of the total votes cast on the proposal in person or by proxy.  As
noted above,  termination of the January  Amendments  would also result from the
failure of  stockholders  to approve  Proposal 3, which requires the affirmative
vote of a majority of the shares of Common  Stock  outstanding  as of the Record
Date. The practical  benefits of Proposal 2 will not be realized unless Proposal
3 is also approved.

     Management and the Board of Directors recommend a vote FOR this Proposal to
approve the issuance of 20% or more of the outstanding Common Stock at discounts
of up to 10% from its market value as of certain dates


      PROPOSAL 3:  APPROVAL OF AN AMENDMENT TO THE COMPANY'S
                   CERTIFICATE OF INCORPORATION

Background

     The Company's Board of Directors has determined that amending the Company's
Certificate of  Incorporation  in the manner described below is advisable and is
in  the  best  interest  of  stockholders  and  recommends  that  the  Company's
stockholders  approve and adopt the proposed  amendment.  The proposed amendment
would  increase the number of authorized  shares of the  Company's  Common Stock
from 19,000,000 to 30,000,000.

     The proposed  amendment to the Company's  Certificate of  Incorporation  is
being recommended as required by the January  Amendments between the Company and
the holders of the  Convertible  Securities,  which  require the Company to seek
stockholder  approval of such an  amendment by June 1, 1998.  In  addition,  the
proposed amendment is being recommended  because the Board of Directors believes
having  shares  authorized  and  available for issuance will provide the Company
with greater flexibility in pursuing funding to meet the Company's capital needs
in the future.


Description of the Proposal

     The proposed  amendment to the Certificate of  Incorporation  will increase
the number of authorized shares of the Company's Common Stock from 19,000,000 to
30,000,000.  As of April  2,  1998,  14,776,287  shares  of  Common  Stock  were
outstanding,  leaving only 4,223,713 shares  authorized but unissued,  an amount
insufficient  to satisfy  its  obligations  for  shares  formally  reserved  for
issuance upon exercise or conversion of outstanding options,  warrants and other
convertible  securities  and shares that could be issuable to the holders of the
Convertible  Securities  upon the approval of Proposal 2. After giving effect to
the return by Mr.  Shaykin of the  Warrant  exercisable  for  111,111  shares of
Common  Stock and the  return  by IVAX of  1,126,398  shares of Common  Stock in
connection with the Termination Agreement, the number of authorized but unissued
shares would still be insufficient as of such date.

     The  purpose  of the  proposed  amendment  to the  current  Certificate  of
Incorporation is to comply with the  requirements of the January  Amendments and
to provide the Company with  additional  options for  securing  financing in the
future.  The Board of  Directors  believes  that  adoption of this  amendment is
necessary to preserve the Company's  resources and allow  flexibility in seeking
further funding for the Company.  In addition,  the Board of Directors  believes
that  adoption  of this  amendment  is  necessary  to prevent the holders of the
Convertible  Securities  from being able to seek  redemption of the  Convertible
Securities  in  amounts  which  would  have a  material  adverse  effect  on the
Company's working capital,  which could, in turn, have a material adverse effect
on the Company's operations.

     If Proposal 3 is  approved,  the newly  authorized  shares of Common  Stock
would have all of the rights and  privileges  of the shares of Common  Stock now
authorized.  The Common Stock has no  preemptive  rights.  Once shares of Common
Stock are  authorized,  the Board of Directors  can issue shares of Common Stock
without stockholder approval, except as may be required by law or regulations or
by the rules of any stock exchange on which the Company's securities may then be
listed.

     Although the Board of Directors would issue additional  shares based on its
judgment  as to the best  interests  of the Company  and its  stockholders,  the
issuance of  additional  shares  would have the effect of diluting  the relative
voting  power per share and could have the effect of diluting the book value per
share of the outstanding shares of Common Stock.

     If Proposal 3 is approved, Article Four of the Certificate of Incorporation
will be amended, in pertinent part, to read as follows:

                           ARTICLE FOUR

          I.   AUTHORIZED SHARES

               The Corporation shall have authority to issue 33,000,000 shares
     of capital stock, 30,000,000 of which shall be Common Stock, with a par
     value of $.0075 per share, 1,000,000 of which shall be Nonvoting Common
     Stock, with a par value of $.0075 per share, and 2,000,000 of which shall
     be Preferred Stock, with a par value of $.001 per share.


Vote Required and Board Recommendation

     The affirmative vote of holders of a majority of the shares of Common Stock
entitled to vote at the meeting is required to approve the  proposed  amendment.
If the amendment is not approved by the stockholders,  the Company's Certificate
of  Incorporation,  which authorizes the issuance of 19,000,000 shares of Common
Stock, will remain unchanged.

     Management and the Board of Directors recommend a vote FOR this Proposal to
approve an amendment to the Company's Certificate of Incorporation


   PROPOSAL 4:  APPROVAL OF AN AMENDMENT TO THE 1994 LONG-TERM
                    PERFORMANCE INCENTIVE PLAN

Description of Proposed Amendment

     Contingent  upon approval by the  stockholders,  the Board of Directors has
adopted an amendment  to the 1994 Plan to increase the maximum  number of shares
of Common  Stock  issuable  as  awards  under  the 1994  Plan  from  875,000  to
1,575,000.


Reasons for Proposed Amendment

     As of April 2, 1998, stock options have been granted under the 1994 Plan to
purchase a total of 842,964  shares,  leaving only 32,036 shares of Common Stock
available for  additional  grant under the 1994 Plan. The Board believes that it
is in the best  interest  of the  Company  to  increase  the  number  of  shares
available for awards under the 1994 Plan,  and to increase the maximum number of
shares that may be awarded each taxable  year,  in order to allow the Company to
grant  awards to attract  and retain new  employees  and to further  compensate,
where appropriate, employees who previously have been awarded, or who previously
have not been awarded, options under the 1994 Plan.


1994 Long-Term Performance Incentive Plan

     In May 1994, the Company's  Board of Directors  adopted the 1994 Plan which
was  subsequently  approved  by the  stockholders  of the  Company  prior to the
Company's  initial public  offering in August 1994 and amended with the approval
of  stockholders  in 1996.  The 1994 Plan, as amended,  provides for granting to
employees  and  other key  individuals  who  perform  services  for the  Company
("Participants") the following types of incentive awards:  stock options,  stock
appreciation rights ("SARs"),  restricted stock,  performance units, performance
grants and other types of awards  that the  Compensation  Committee  deems to be
consistent  with the  purposes  of the 1994  Plan.  The 1994 Plan also  provides
non-employee  directors  with stock option  grants  according to an  established
formula and  permits the  discretionary  grant of  non-qualified  options by the
Board of Directors to non-employee directors under certain circumstances.

     The  1994  Plan  affords  the  Company  latitude  in  tailoring   incentive
compensation  to support  corporate and business  objectives,  to anticipate and
respond  to  a  changing  business  environment  and  competitive   compensation
practices  and, in the case of options  granted to  non-employee  directors,  to
strengthen   further  the  non-employee   directors'  linkage  with  stockholder
interests.

     The following is a description of the principal features of the 1994 Plan.

     Shares  Subject to Plan.  The 1994 Plan  currently  allows for  issuance of
875,000  shares of Common  Stock as awards.  Stockholder  approval of Proposal 4
would increase the number of shares of Common Stock issuable as awards under the
1994 Plan to 1,575,000.

     Administration.  The  Compensation  Committee has  exclusive  discretion to
select the Participants and to determine the type, size and terms of each award,
to modify the terms of awards,  to  determine  when  awards  will be granted and
paid, and to make all other determinations which it deems necessary or desirable
in the  interpretation  and  administration  of the 1994  Plan.  The  1994  Plan
terminates ten years from the date that it is initially  approved and adopted by
the  stockholders  of the Company,  unless extended for up to an additional five
years by action of the Board of Directors.  With limited  exceptions,  including
termination  of employment as a result of death,  disability or  retirement,  or
except as otherwise  determined by the Compensation  Committee,  rights to these
forms of contingent compensation will be forfeited if a Participant's employment
or performance of services  terminates  within a specified  period following the
award.  Generally,  a Participant's rights and interest under the 1994 Plan will
not be transferable except by will or by laws of descent and distribution.

     Awards.  Under the 1994 Plan,  Participants  are granted  incentive  awards
consisting  of  stock  options,  SARs,  restricted  stock,   performance  units,
performance grants and other types of awards.

     Stock  Options.  Participants  are  granted  stock  options  which  include
non-qualified  stock  options and  incentive  stock  options.  Stock options are
rights to purchase a specified number of shares of Common Stock at a price fixed
by the  Compensation  Committee.  The option price may not be less than the fair
market value of the underlying  shares of Common Stock on the date of grant.  In
the case of purchased stock options,  a specified number of non-qualified  stock
options  (with an option price as described  above) will be offered for grant to
selected  Participants  in  exchange  for a  purchase  price,  specified  by the
Compensation Committee, which is payable at the time of grant. Options generally
will expire not later than ten years  after the date on which they are  granted.
Options will become  exercisable at such times and in such  installments  as the
Compensation Committee shall determine. Payment of the option price must be made
in full at the time of  exercise  in such form  (including,  but not limited to,
cash,  Common  Stock  or the  surrender  of  another  outstanding  award  or any
combination thereof) as the Compensation Committee may determine. Federal income
tax payable as a  consequence  of the  exercise of such  options is borne by the
grantee.

     SARs.  SARs may be granted  alone,  or a holder of an option or other award
may be  granted  a  related  SAR,  either  at the time of grant or by  amendment
thereafter.  Upon  exercise  of an SAR,  the holder must  surrender  the SAR and
surrender,  unexercised,  any related option or other award, and the holder will
receive in exchange,  at the  election of the  Compensation  Committee,  cash or
Common Stock or other consideration,  or any combination thereof, equal in value
to  (or,  in the  discretion  of the  Compensation  Committee,  less  than)  the
difference  between the  exercise  price or option  price per share and the fair
market value per share of Common Stock on the last  business day  preceding  the
date of  exercise,  times the  number of shares  subject to the SAR or option or
other award, or portion thereof, which is exercised.

     Restricted  Stock  Awards.  A  restricted  stock  award  is an  award  of a
specified  number of shares of Common  Stock which are subject to a  restriction
against  transfer  and  to a risk  of  forfeiture  during  a  period  set by the
Compensation Committee. During the restriction period, the Participant generally
has the right to vote and receive dividends on the shares.

     Performance  Grants and Other Awards.  Performance grants are awards with a
final  value,  if any,  that is  determined  by the  degree  to which  specified
performance  objectives  have been  achieved  during an award  period set by the
Compensation  Committee,   subject  to  such  adjustments  as  the  Compensation
Committee  may approve based on relevant  factors.  Performance  objectives  are
based  on  various  measures  of  performance,  including,  without  limitation,
measures  of  industry,   Company,  unit  or  Participant  performance,  or  any
combination of the foregoing,  as the Compensation Committee may determine.  The
Compensation  Committee  may make such  adjustments  in the  computation  of any
performance measure as it may deem appropriate.  A target value of an award will
be established (and may be amended thereafter) by the Compensation Committee and
may be a fixed dollar  amount,  an amount that varies from time to time based on
the value of a share of Common  Stock,  or an amount that is  determinable  from
other criteria  specified by the  Compensation  Committee.  Payment of the final
value of an award will be made as promptly as  practicable  after the end of the
award period or at such other time or times as the  Compensation  Committee  may
determine.  The 1994  Plan  permits  the grant of any  other  type of  incentive
compensation  award  determined by the  Compensation  Committee to be consistent
with the purposes of the 1994 Plan.

     Awards to Non-Employee  Directors.  The 1994 Plan provides that each person
who is not an employee of the Company or any of its  subsidiaries and who (i) is
elected or re-elected  as a director of the Company at an annual  meeting of the
Company's  stockholders,  (ii)  continues  service as a director  of the Company
after an annual meeting of the Company's  stockholders  at which the director is
not subject to  re-election,  or (iii) is appointed as a director of the Company
in  accordance  with its Bylaws  following  an annual  meeting of the  Company's
stockholders (each, an "Eligible Director"),  will receive, on the next business
day  following  each such election or  appointment,  a  non-qualified  option to
purchase a specified number of shares of the Company's Common Stock.  Currently,
non-employee  directors  are entitled to receive an option for 10,000  shares of
Common Stock under such  automatic  provisions.  The 1994 Plan also provides for
automatic  annual grants of options to purchase 10,000 shares of Common Stock to
the chair of the Audit,  Compensation and Strategic  Planning  Committees of the
Board of Directors.  Each option granted to non-employee  directors will have an
option price equal to the fair market value of the Company's Common Stock on the
date  of  grant,  will  generally  become  exercisable  in  full  on  the  first
anniversary  following  the date of grant and will have a term of 10 years  from
the date of grant.  The 1994 Plan also provides for the  discretionary  grant of
non-qualified options by the Board of Directors to non-employee  directors under
certain circumstances.

     Liquidation;   Changes  in  Control;   Mergers.  Upon  the  liquidation  or
dissolution  of the  Company,  all  outstanding  awards under the 1994 Plan will
terminate   immediately  prior  to  the  consummation  of  such  liquidation  or
dissolution,  unless  otherwise  provided by the  Compensation  Committee.  Upon
certain  events,  including  (i) any  "person,"as  such term is used in Sections
13(d) and 14(d) of the Exchange  Act,  including a "group" as defined in Section
13(d) of the Exchange Act but excluding the Company and any  subsidiary  and any
employee  benefit plan  sponsored or maintained by the Company or any subsidiary
(including any trustee of such plan acting as trustee),  directly or indirectly,
becoming  the  "beneficial  owner" (as defined in Rule 13d-3 under the  Exchange
Act, as amended from time to time),  of securities  of the Company  representing
25% or more of the  combined  voting  power of the  Company's  then  outstanding
securities;  (ii)  individuals  who at the  beginning  of  any  12-month  period
constituted  the Board  ceasing for any reason other than death to  constitute a
majority of such Board;  or (iii)  approval by the Company's  stockholders  of a
transaction involving the acquisition of the Company by an entity other than the
Company or any subsidiary  through purchase of assets,  by merger, or otherwise,
(A) any SARs and any options will become  immediately  exercisable  in full; (B)
restrictions  and deferral  limitations  applicable to any restricted  stock and
other awards payable in shares of Common Stock will lapse and become immediately
exercisable in full; (C) generally,  outstanding  performance grants will become
vested and will be paid out based on the prorated  target results for the awards
period in question;  and (D) generally,  the value of all  outstanding  options,
SARs,  restricted stock,  performance grants and any other type of award payable
in shares of Common Stock will be cashed out.

     Amendment and Termination.  The Board may amend or suspend the 1994 Plan in
whole or in part at any time  provided  that  stockholder  approval  is obtained
where failure to obtain such approval would  adversely  affect the compliance of
the 1994 Plan with Rule 16b-3 under the Exchange  Act and with other  applicable
law. The 1994 Plan will  terminate on June 16, 2004 unless sooner  terminated by
the Board.  No amendment or termination  of the Plan may  materially  affect any
rights of a Participant with respect to any award without the written consent of
the Participant  except where, in the Compensation  Committee's  discretion,  it
determines that significant  changes in the  Participant's  position,  duties or
responsibilities,  or significant changes in economic, legislative,  regulatory,
tax,  account or  cost/benefit  conditions  have had or will have a  substantial
effect  on the  performance  of the  Company  or  any  of  its  subsidiaries  or
affiliates.

     Federal Income Tax  Consequences of the Grant and Exercise of Options Under
the  1994  Plan.  The  tax  consequences  applicable  to  the  Company  and to a
Participant in the 1994 Plan in connection with options granted to a participant
are  complex  and  depend,   in  large  part,  on  the  surrounding   facts  and
circumstances.  The following brief summary of certain significant United States
federal  income  tax  consequences  under  existing  law of the 1994 Plan is not
intended to be  exhaustive  and,  among other things,  does not describe  state,
local or foreign tax consequences.

     Under the Code,  the grant of a stock  option  does not  result in  taxable
income  to the  optionee  or any tax  deduction  to the  Company.  However,  the
transfer  of common  stock of the  Company to an  optionee  upon  exercise of an
option  may or may not give  rise to  taxable  income  to the  optionee  and tax
deductions  to the  Company,  depending  upon  whether  or not the  option is an
incentive stock option or non-qualified option.

     In general,  a Participant  will not recognize any income upon the exercise
of an  incentive  stock  option,  and the Company  will not be entitled to a tax
deduction on account of such exercise.  However,  a Participant could be subject
to the alternative minimum tax upon exercise.  If the Code requirements relating
to the holding  periods for stock  acquired  on exercise of an  incentive  stock
option have been satisfied, a Participant who acquires Company Common Stock upon
the exercise of his or her  incentive  stock option will  recognize  any gain or
loss  realized  upon the sale of such  stock as  capital  gain or loss,  but the
Company will not be entitled to any tax  deduction  on account of such sale.  If
such holding  period  requirements  are not satisfied with respect to such stock
acquired on  exercise of an  incentive  stock  option,  the sale of the stock so
acquired will result in ordinary  income being  recognized by the Participant in
an amount  equal to the excess,  with  certain  adjustments,  of the fair market
value of the underlying  stock on the date of exercise over the option price and
the Company will be entitled to a tax  deduction  in the same  amount,  assuming
that the compensation  amounts satisfy the ordinary and reasonable  compensation
requirements for  deductibility and that the deduction is not limited by Section
162(m) of the Code. Any additional  gain realized by such  Participant on such a
sale of his or her stock will be capital gain. If the total amount realized upon
such a sale is less than the exercise price of the incentive  stock option,  the
difference will be a capital loss to such Participant.

     In the  case  of a  non-qualified  option,  a  Participant  generally  will
recognize  ordinary  income upon the exercise of such option in the amount equal
to the excess of the fair market  value of the  underlying  stock on the date of
exercise  over the option  price,  and the  Company  will be  entitled  to a tax
deduction in the same amount, assuming that the compensation amounts satisfy the
ordinary and reasonable compensation requirements for deductibility and that the
deduction is not limited by Section 162(m) of the Code. If, however, the sale of
Common  Stock of the  Company  at a profit  would  subject  the  Participant  to
liability  under  Section  16(b)  of the  Exchange  Act,  the  Participant  will
recognize  compensation  income equal to the excess of (i) the fair market value
of such  Common  Stock on the  earlier of the date that is six months  after the
date of exercise or the date the  Participant  can sell the Common Stock without
liability under Section 16(b) over (ii) the exercise price.  The Participant can
make an election under Section 83(b) of the Code to measure the  compensation as
of the date the non-qualified option is exercised.  A Participant will recognize
as capital  gain or loss any profit or loss  realized on the sale or exchange of
any such shares disposed of or sold.

     Under Section  162(m) of the Code, the Company may be limited as to federal
income tax deductions to the extent that total annual  compensation in excess of
$1 million is paid to the chief  executive  officer of the Company or any one of
the other four highest paid  executive  officers  employed by the Company on the
last day of the taxable year. However, certain "performance-based compensation,"
the  material  terms of which are  disclosed  to and  approved by the  Company's
stockholders,   is  not  subject  to  this  limitation  on  deductibility.   The
Corporation  has  structured  the stock option and SAR portions of the 1994 Plan
with the intention  that  compensation  resulting  therefrom  would be qualified
performance-based  compensation  and would be deductible  without  regard to the
limitations  otherwise  imposed  by  Section  162(m) of the Code.  The 1994 Plan
allows the Committee  discretion to award restricted stock and other stock-based
awards that are intended to be qualified performance-based compensation. Bonuses
and other compensation  payable in stock under the 1994 Plan are not intended to
qualify as performance-based compensation.


New Plan Benefits

     The future  benefits or amount that will be received by executive  officers
and other employees of the Company under the 1994 Plan are not determinable,  as
grants to such persons are  determined  in the  discretion  of the  Compensation
Committee and the Board of Directors.  Under the formula  provisions of the 1994
Plan, the non-employee  directors of the Company,  Dr. Hayes and Mr. Hacken will
each  receive  automatically  on the date of the  Annual  Meeting  non-qualified
options to purchase  20,000  shares of Common  Stock and Dr.  Steer will receive
automatically  on such date a non-qualified  option to purchase 10,000 shares of
Common Stock.


Vote Required and Board Recommendation

     The affirmative vote of holders of a majority of the shares of Common Stock
entitled to vote at the meeting is required to approve the  proposed  amendment.
If the amendment is not approved by the  stockholders,  the Company's  1994 Plan
will continue in effect without the proposed amendments.

     Management and the Board of Directors recommend a vote FOR this Proposal to
approve an amendment to the 1994 Long-Term Performance Incentive Plan.


  PROPOSAL 5:  RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS

Ratification of Selection of Independent Auditors

     The Board of  Directors  has  selected  Ernst & Young LLP as the  Company's
independent  auditors for the year ending  December  31,  1998,  and has further
directed  that  management  submit this  selection of  independent  auditors for
ratification by the  stockholders at the Annual Meeting.  Ernst & Young LLP have
audited the Company's financial statements for 1997.  Representatives of Ernst &
Young LLP who are  expected  to be present at the  Annual  Meeting  will have an
opportunity to make a statement if they desire to do so and will be available to
respond  to  appropriate  questions.  If a majority  of the shares  voted at the
Annual  Meeting do not vote for  ratification  of the selection of Ernst & Young
LLP, the Board of Directors will reconsider such selection.

     Management and the Board of Directors Recommend a Vote FOR this Proposal to
ratify the selection of Ernst & Young LLP as the Company's independent auditors.


OTHER MATTERS

     The Board of  Directors  knows of no other  business to be presented at the
Annual Meeting, but if other matters do properly come before the Annual Meeting,
it is intended that the persons named in the proxy will vote in respect  thereof
in accordance with their best judgment.

     The Board of Directors  encourages you to have your shares voted by signing
and  returning  the enclosed  proxy.  The fact that you will have  returned your
proxy in advance will not affect your right to vote in person should you find it
possible  to attend.  However,  by signing  and  returning  the proxy,  you have
assured  your  representation  at  the  Annual  Meeting.   Thank  you  for  your
cooperation.

                                   By Order of the Board of Directors,




                                   Patricia A. Pilia
                                   Secretary

Boulder, Colorado
April 27, 1997

<PAGE>


                           COMMON STOCK
                   NAPRO BIOTHERAPEUTICS, INC.

          PROXY SOLICITED BY THE BOARD OF DIRECTORS FOR
  THE ANNUAL MEETING OF STOCKHOLDERS TO BE HELD ON MAY 28, 1998

     The undersigned  hereby appoints Leonard P. Shaykin,  Sterling K. Ainsworth
and Patricia A. Pilia,  or any of them,  with full power of  substitution,  as a
proxy or proxies to represent the undersigned at the Annual Meeting (the "Annual
Meeting") of Stockholders of NAPRO  BIOTHERAPEUTICS,  INC. (the "Company") to be
held on May 28,  1998,  at 9:00 a.m. at the  Conference  Center at the  Raintree
Plaza Hotel, 1850 Industrial Circle, Longmont, Colorado, and at any adjournments
or  postponements  thereof,  and to vote thereat all the shares of Common Stock,
$.0075 par value per share,  held of record by the  undersigned  at the close of
business on April 2, 1998, with all the power that the undersigned would possess
if personally present, as designated on the reverse side.

     Shares will be voted as specified. THE BOARD OF DIRECTORS RECOMMENDS A VOTE
FOR AND APPROVAL OF THE PROPOSALS.  IF NO SPECIFICATION IS MADE, THIS PROXY WILL
BE VOTED  IN FAVOR OF EACH OF THE  PROPOSALS  IN  ACCORDANCE  WITH THE  BOARD OF
DIRECTORS  RECOMMENDATIONS.  The proxies or substitutes may vote  accordingly in
their  discretion  upon any other  business  that may  properly  come before the
Annual Meeting or any adjournments thereof.

                  (To Be Signed on Reverse Side)

<PAGE>


/__X__/   Please mark your votes as in this example.

MANAGEMENT RECOMMENDS VOTING "FOR" EACH NOMINEE NAMED

1.   Election of Directors:
     (to serve until the Company's 2001 Annual Meeting)

/____/    FOR            /____/    WITHHELD

     Nominees: Dr. Patricia A. Pilia
               Dr. Randolph C. Steer

     INSTRUCTIONS:  To withhold authority to vote for either nominee, write that
nominee's  name on the  line  provided  below.  IF  AUTHORITY  IS NOT  EXPRESSLY
WITHHELD, IT SHALL BE DEEMED GRANTED.

- ------------------------------


2.   Issuance of 20% or more of the outstanding Common Stock in connection with
     each of the Company's Senior Convertible Notes and Series C Convertible
     Preferred Stock.

     /____/    FOR            /____/    AGAINST        /____/    ABSTAIN

- -------------------------------------------------------------------

3.   Amendments to the Company's Certificate of Incorporation to increase the
     number of authorized shares of Common Stock from 19,000,000 to 30,000,000.

     /____/    FOR            /____/    AGAINST        /____/    ABSTAIN

4.   Amendment of the Company's 1994 Long-Term Performance Incentive Plan to
     increase the maximum number of shares of Common Stock issuable as awards
     thereunder from 875,000 to 1,575,000.

     /____/    FOR            /____/    AGAINST        /____/    ABSTAIN

5.   Ratification of the selection by the Board of Directors of Ernst & Young
     LLP as the Company's independent auditors for the year ending December 31,
     1998.

     /____/    FOR            /____/    AGAINST        /____/    ABSTAIN

- -------------------------------------------------------------------


___________________________________________  __________ DATE _____
     SIGNATURE                                 TITLE

___________________________________________  __________ DATE _____
     SIGNATURE IF HELD JOINTLY                 TITLE

     NOTE:  Please sign this proxy as your name appears  hereon,  including  the
title "Executor,"  "Trustee," etc. if such is indicated.  If joint account, each
joint owner  should  each sign.  If stock is held by a  corporation,  this proxy
should be executed by a proper officer thereof.

PLEASE DATE AND SIGN THIS PROXY AND RETURN IT IN THE ENCLOSED ENVELOPE.


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