NAPRO BIOTHERAPEUTICS INC
8-K, 1998-01-12
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                                        SECURITIES AND EXCHANGE COMMISSION
                                               WASHINGTON, DC 20549


                                       ------------------------------------


                                                     FORM 8-K

                                                  CURRENT REPORT


          Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934



Date of report (Date of earliest event reported):  January 6, 1998         


- --------------------------------------------------------------------------------

                              (Exact Name of Registrant as Specified in Charter)


 Delaware                         0-243201                 84-1187753
- --------------------------------------------------------------------------------
(State or Other Jurisdiction of  (Commission File Number) (I.R.S. Employer
 Incorporation)                                           Identification Number)
                                                                                

6304 Spine Road, Unit A, Boulder, Colorado   80301
- --------------------------------------------------------------------------------
(Address of Principal Executive Offices)    (Zip code)


Registrant's telephone number, including area code:  (303) 530-3891             

                                        1

<PAGE>


Item 5.  Other Events

         On January 8, 1997, the Company  issued the press releases  relating to
(i) modification of its agreements with the holder of its 5% Senior  Convertible
Notes due June 4, 2000 and  Series C  Convertible  Preferred  Stock and (ii) the
issuance  to the  Company  of a patent  with  respect to the  administration  of
Paclitaxel.

Item 7.  Financial Statements, Pro Forma Financial Information and Exhibits

         (c)      Exhibits.


Exhibit No.                 Exhibit Description
4.1                         Agreement in Principle, dated as of January 6, 1998,
                            by and among the Registrant and the noteholders
                            named therein.
4.2                         Agreement in Principle, dated as of January 6, 1998,
                            by and between the Registrant and Omicron Partners,
                            L.P.
4.3                         Agreement in Principle, dated as of January 6, 1998,
                            by and between the Registrant and Advantage Fund II,
                            Ltd.
99.1                        Press Release dated January 8, 1998 regarding
                            Restructuring


99.2                        Press Release dated January 8, 1998 regarding patent


                                                         2

<PAGE>



                                                    SIGNATURES



         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                                     NAPRO BIOTHERAPEUTICS, INC.



                                                      By:\s\ Gordon H. Link, Jr.

                                                      Gordon H. Link, Jr.
                                                      Chief Financial Officer

Date:  January 9, 1998    



                                                         3

<PAGE>




Exhibit 4.1

AGREEMENT IN PRINCIPLE


                  THIS AGREEMENT IN PRINCIPLE, dated as of January 6, 1998 (this
"Agreement"), by and between NAPRO BIOTHERAPEUTICS, INC., a Delaware corporation
(the  "Company"),  and each of the  undersigned  holders  (each,  a "Holder" and
collectively,  the "Holders") of the Company's Senior Convertible Notes due June
4, 2000 (each, a "Note" and collectively, the "Notes").

                  1.  The  Company  and each  Holder  agree  in  principle  to a
modification  of the  terms of such  Holder's  Note as  described  on  Exhibit A
attached hereto.

                  2. This  Agreement  is  subject to  preparation,  negotiation,
execution and delivery on or before January 19, 1998 of definitive documentation
setting forth the modifications  described on Exhibit A attached hereto on terms
mutually  satisfactory  to the Company and each Holder and approval of the terms
of such  documents by the Boards of Directors or similar  persons of the Company
and each Holder.

                  3. In  connection  with this  Agreement,  the Company and each
Holder have executed a Mandatory Redemption Waiver, dated as of the date hereof,
in the form attached hereto as Exhibit B.

                  4.  This  Agreement  shall be  governed  by and  construed  in
accordance  with the laws of the State of New York applicable to contracts to be
made and performed entirely in the State of New York.

                  IN WITNESS  WHEREOF,  the  parties  hereto  have  caused  this
Agreement to be duly executed by their officers or other  representatives  as of
the date first set forth above.

                                                  NAPRO BIOTHERAPEUTICS, INC.



                                                  By: \s\ Gordon H. Link, Jr.
                                                  Name:Gordon H. Link, Jr.
                                                  Title: Chief Financial Officer


                                                  DELTA OPPORTUNITY FUND, LTD.



                                                         4

<PAGE>




                                                  By:/s/
                                                  Name:
                                                  Title:


                                                  NELSON PARTNERS



                                                  By:/s/
                                                  Name:
                                                  Title:


                                                  OLYMPUS SECURITIES, LTD.



                                                  By:/s/
                                                  Name:
                                                  Title:


                                                  OTATO LIMITED PARTNERSHIP



                                                  By:/s/
                                                  Name:
                                                  Title:


                                                  DIAZ & ALTSCHUL GROUP, LLC



                                                  By:/s/
                                                  Name:
                                                  Title:


                                     5

<PAGE>




Exhibit 4.2

AGREEMENT IN PRINCIPLE


                  THIS AGREEMENT IN PRINCIPLE, dated as of January 6, 1998 (this
"Agreement"), by and between NAPRO BIOTHERAPEUTICS, INC., a Delaware corporation
(the  "Company"),  and  the  undersigned  holder  (the  "Holder")  of one of the
Company's Senior Convertible Notes due June 4, 2000 (the "Note").

                  1. With regard to the  Inconvertibility  Notices  given by the
Holder on or prior to the date of this Agreement,  the Company shall satisfy all
obligations to redeem a portion of the Note arising from the inconvertibility of
the Note specified in such Inconvertibility Notices by payment of $150,000 (plus
accrued and unpaid interest to the date of payment) to the Holder in immediately
available  funds on or before  January 8, 1998. The parties agree that upon such
payment, the principal amount outstanding of the Note shall be $1,258,257.49. No
reduction  of the Maximum  Share Amount  shall be made in  connection  with such
payment.

                  2. The Company shall prepay an aggregate of $250,000 principal
amount of the Note in equal  monthly  installments  of $62,500 (plus accrued and
unpaid  interest  thereon  to the date of  repayment)  on the  first day of each
calendar month,  commencing  February 1, 1998. No reduction of the Maximum Share
Amount shall be made in connection with any such repayment.  Notwithstanding the
foregoing  provisions  of this Section 2, if for any period of five  consecutive
Trading Days on or after the date of this  Agreement the  arithmetic  average of
the Market  Price of the  Common  Stock is at least  $3.75 per  share,  then the
Company shall have no further obligation to make payments to the Holder pursuant
to this Section 2 (other than  payments  which became due prior to the date such
average Market Price occurred).

                  3.  The  Company  and  the  Holder  agree  in  principle  to a
modification  of the  $1,008,257.49  principal  amount  of  such  Holder's  Note
remaining  (after the amounts  referred to in Sections 1 and 2) as  described on
Exhibit A attached hereto. At such time as the Company is no longer obligated to
repay the  portion of the Note  provided  in Section 2, such  remaining  portion
shall  also be  subject  to the  modifications  described  on Exhibit A attached
hereto.

                  4. This  Agreement  is  subject to  preparation,  negotiation,
execution and delivery on or before January 19, 1998 of definitive documentation
setting forth the modifications  described on Exhibit A attached hereto on terms
mutually  satisfactory  to the Company and each Holder and approval of the terms
of such  documents by the Boards of Directors or similar  persons of the Company
and each Holder.

                  5. In  connection  with this  Agreement,  the  Company and the
Holder have executed a Mandatory Redemption Waiver, dated as of the date hereof,
in the form attached hereto as Exhibit B.

                                                         6

<PAGE>




    6. Capitalized terms used in this Agreement and not otherwise defined herein
shall have the respective meanings provided in the Note.

                  7.  This  Agreement  shall be  governed  by and  construed  in
accordance  with the laws of the State of New York applicable to contracts to be
made and performed entirely in the State of New York.

                  IN WITNESS  WHEREOF,  the  parties  hereto  have  caused  this
Agreement to be duly executed by their officers or other  representatives  as of
the date first set forth above.

                                                NAPRO BIOTHERAPEUTICS, INC.



                                                By: \s\ Gordon H. Link, Jr.
                                                Name:Gordon H. Link, Jr.
                                                Title: Chief Financial Officer


                                                OMICRON PARTNERS, L.P.



                                                By:/s/
                                                Name:
                                                Title:



                                                         7

<PAGE>




Exhibit 4.3

AGREEMENT IN PRINCIPLE


                  THIS AGREEMENT IN PRINCIPLE, dated as of January 6, 1998 (this
"Agreement"), by and between NAPRO BIOTHERAPEUTICS, INC., a Delaware corporation
(the  "Company"),  and  ADVANTAGE  FUND  II,  LTD.,  a  British  Virgin  Islands
corporation (the "Holder").

                  1.  The  Company  and  the  Holder  agree  in  principle  to a
modification of the terms of the Company's Series C Senior Convertible Preferred
Stock as described on Exhibit A attached hereto.

                  2. This  Agreement  is  subject to  preparation,  negotiation,
execution and delivery on or before January 19, 1998 of definitive documentation
setting forth the modifications  described on Exhibit A attached hereto on terms
mutually satisfactory to the Company and the Holder and approval of the terms of
such documents by the Boards of Directors or similar  persons of the Company and
the Holder.

                  3.  This  Agreement  shall be  governed  by and  construed  in
accordance  with the laws of the State of New York applicable to contracts to be
made and performed entirely in the State of New York.

                  IN WITNESS  WHEREOF,  the  parties  hereto  have  caused  this
Agreement to be duly executed by their officers or other  representatives  as of
the date first set forth above.

                                                NAPRO BIOTHERAPEUTICS, INC.



                                                By: \s\ Gordon H. Link, Jr.
                                                Name:Gordon H. Link, Jr.
                                                Title: Chief Financial Officer


                                                ADVANTAGE FUND II, LTD.



                                                By:/s/
                                                Name:
                                                Title:

                                                         8

<PAGE>




  Exhibit 99.1

  NaPro Restructures Outstanding Convertible Securities

  BOULDER, Colo.--(BW  HealthWire)--Jan.  8, 1998--NaPro  BioTherapeutics,  Inc.
  (Nasdaq:  NPRO)  announced  today that the Company has reached  agreements  in
  principle  with the holders of its 5% Senior  Convertible  Notes (the "Notes")
  and its Series C Convertible  Preferred  Stock (the  "Preferred  Stock") which
  were  designed to, over the period  through  December  31,  1998:  (I) fix the
  maximum number of shares which could issued under the combined  instruments at
  approximately 5.6 million shares,  (II) limit the number of shares which could
  be  converted in the event the stock price is below $4.00 per share to no more
  than 450,000  shares per month and (III)  suspend the ability of the investors
  to force the Company to redeem any portion of their Notes or  Preferred  Stock
  for cash. In the event there is an unconverted amount on January 1, 1999, such
  amount will be  convertible  under the original  terms of the  agreements.  If
  prior to December 31,  1998,  the maximum  conversion  shares are issued at an
  average  conversion  price  of  about  $2.70  per  share,  there  will  be  no
  convertible securities outstanding at year end.

  Under the original  terms of the notes,  in late December  1997, in connection
  with a  substantial  decline in the  Company's  stock price,  a portion of the
  principal  amount  of the  Notes  became  inconvertible.  Absent a  waiver  or
  modification of its  arrangements  with the holders of the Notes,  the Company
  would have been required to have redeemed for cash the  inconvertible  portion
  of such Notes. The Preferred Stock contains  similar  limitations with respect
  to its conversion.

  The agreements in principle are subject to negotiation of mutually  acceptable
  documentation which the Company expects to be completed by January 19, 1998.

  NaPro  BioTherapeutics,   Inc.  headquartered  in  Boulder,   Colorado,   with
  additional  manufacturing  and  plantation  operations  in  British  Columbia,
  Canada, is a biopharmaceutical company focused on the development,  production
  and licensing of complex natural-product pharmaceuticals.

  Except for the historical  matters contained herein,  statements in this press
  release  are  forward  looking  and  are  made  pursuant  to the  safe  harbor
  provisions  of the  Securities  Litigation  Reform Act of 1995.  Investors are
  cautioned  that forward  looking  statements  involve risks and  uncertainties
  which may affect NaPro's business and prospects,  including the risk that IVAX
  may not  obtain  regulatory  approval  or  successfully  commercialize  Paxene
  (IVAX's  formulation of NaPro paclitaxel) and certain  economic,  competative,
  governmental,  technological  and other factors  discussed in NaPro's  filings
  with the Securities and Exchange Commission  including the Form 8K to be filed
  in conjunction with this transaction.

  Contact:                                        Gordon Link
                                                  NaPro BioTherapeutics, Inc.
                                                  VP and Chief Financial Officer
                                                  tel: (303) 530-3891

                                                                              Or

                                                  Ruth Markowitz (investors)
                                                  Lisa Burns (media)
                                                  Burns McClellan, Inc.

                                                         9

<PAGE>



                                                  Tel: (212) 213-0006

                                                        10

<PAGE>



  Exhibit 99.2

  NAPRO RECEIVES PACLITAXEL ADMINISTRATION PATENT

  BOULDER, CO. -- January 8, 1998 -- NaPro BioTherapeutics,  Inc. (Nasdaq: NPRO)
  announced  today that it has  received a United  States  Patent  relating to a
  novel  method of  administering  paclitaxel.  This  patented  method  involves
  administering smaller, more frequent doses of the drug over a shorter infusion
  time compared to the administration schedule currently approved by the FDA for
  Bristol-Myers Squibb's paclitaxel product.

  Commenting on potential implications of the patent, Dr. Sterling K. Ainsworth,
  NaPro's President and Chief Executive Officer,  said: "The data upon which the
  patent  application  was based was derived from in- vitro and animal  studies,
  and  treatment  of  human  cancer  patients  using  the  patented  method.  No
  controlled clinical trials,  however, have been performed using this method of
  administration.  This novel administration  method was designed based upon our
  understanding  of the way in which  paclitaxel  works to inhibit  cancer  cell
  division."

     The patent has been assigned number 5,696,153 and is entitled  "Therapeutic
  Regimen for Treating Patients."

  Napro  paclitaxel  is  currently  being sold  commercially  in nine  countries
  outside of the United  States  through IVAX in South  America and through F.H.
  Faulding  Co. LTD in  Australia,  the middle East and  Southeast  Asia.  NaPro
  BioTherapeutics,  Inc.  headquartered  in Boulder,  Colorado,  with additional
  manufacturing  and plantation  operations in British  Columbia,  Canada,  is a
  biopharmaceutical company focused on the development, production and licensing
  of complex natural-product pharmaceuticals.

  Except for the historical  matters contained herein,  statements in this press
  release  are  forward  looking  and  are  made  pursuant  to the  safe  harbor
  provisions  of the  Securities  Litigation  Reform Act of 1995.  Investors are
  cautioned  that forward  looking  statements  involve risks and  uncertainties
  which may affect NaPro's business and prospects,  including the risk that IVAX
  may not  obtain  regulatory  approval  or  successfully  commercialize  Paxene
  (IVAX's  formulation of NaPro paclitaxel) and certain  economic,  competative,
  governmental,  technological  and other factors  discussed in NaPro's  filings
  with the Securities and Exchange Commission.

  Contact:                                        Gordon Link
                                                  NaPro BioTherapeutics, Inc.
                                                  VP and Chief Financial Officer
                                                  tel: (303) 530-3891

                                                                              Or

                                                  Ruth Markowitz (investors)
                                                  Lisa Burns (media)
                                                  Burns McClellan, Inc.
                                                  Tel: (212) 213-0006

                                                        11

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