NAPRO BIOTHERAPEUTICS INC
10-Q, 1998-11-13
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                                    FORM 10-Q


                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                    Quarterly Report under Section 13 of the
                         Securities Exchange Act of 1934

                        Quarter ended September 30, 1998


                         Commission File Number 0-24320


                           NaPRO BIOTHERAPEUTICS, INC.


Incorporated in Delaware                                   IRS ID No. 84-1187753

                             6304 Spine Road, Unit A
                                Boulder, CO 80301
                                 (303) 530-3891


NaPro BioTherapeutics, Inc. ("NaPro" or "the Company") (1) has filed all reports
required to be filed by Section 13 of the Securities Exchange Act of 1934 during
the  preceding 12 months,  and (2) has been subject to such filing  requirements
for the past 90 days.

The number of shares outstanding of each of the issuer's classes of common stock
as of November 2, 1998:

Common Stock, $.0075 par value                               16,114,444
Non-voting Common Stock, $.0075 par value                       395,000


Total number of pages in document--17

                                       1

<PAGE>



                           NaPro BioTherapeutics, Inc.

                                Table of Contents

                                                                            Page
Part I   Financial Information

         Consolidated Financial Statements

              Balance Sheet                                                    3

              Statement of Operations                                          5

              Cash Flow Statement                                              6

              Notes to Consolidated Financial Statements                       7

         Management's Discussion and Analysis of Financial 
         Condition and Results of Operations                                   9

         Quantitative and Qualitative Disclosures about Market Risk           15


Part II  Other Information

         Legal Proceedings                                                    15

         Changes in Securities                                                16

         Defaults upon Senior Securities                                      16

         Submission of Matters to a Vote of Security Holders                  16

         Other Information                                                    16

         Exhibits and Reports on Form 8-K                                     17

Signatures                                                                    17


                                        2

<PAGE>



                          Part I. Financial Information

Item 1.  Consolidated Financial Statements
<TABLE>
<CAPTION>


                           NaPro BioTherapeutics, Inc.
                                  Balance Sheet
                                     Assets




                                                                               September 30,             December 31,
                                                                                   1998                     1997
                                                                                (unaudited)


Current assets:
         <S>                                                                   <C>                       <C> 

         Cash and cash equivalents                                             $   9,135,000             $   8,102,000
         Accounts receivable                                                         429,000                 1,508,000
         Inventory                                                                 4,171,000                 3,122,000
           Restricted cash                                                         1,660,000                       ---
         Prepaid expense and other                                                  415,000                   481,000
                                                                             ---------------           --------------
Total current assets                                                              15,810,000                13,213,000

Property and equipment, net                                                       13,221,000                15,187,000
Restricted cash                                                                      195,000                   246,000
Inventory                                                                            908,000                 1,176,000
Other assets                                                                        493,000                   536,000
                                                                             ---------------           --------------
Total assets                                                                   $ 30,627,000              $ 30,358,000 
                                                                               =============             =============
</TABLE>















                             See accompanying notes

                                        3

<PAGE>

<TABLE>
<CAPTION>


                           NaPro BioTherapeutics, Inc.
                                  Balance Sheet
                      Liabilities and Stockholders' Equity


                                                                              September 30,            December 31,
                                                                                   1998                    1997
                                                                                (unaudited)


Current liabilities:
         <S>                                                                  <C>                      <C>

         Accounts payable                                                     $    1,462,000           $     4,361,000
         Accrued payroll and payroll taxes                                           592,000                   570,000
         Notes payable--current portion                                              450,000                   743,000
         Senior Convertible debt                                                         ---                 8,134,000
         Deferred revenue                                                          3,669,000                 1,890,000
                                                                             ---------------            --------------
Total current liabilities                                                          6,173,000                15,698,000

Notes payable--long term                                                             223,000                   480,000
Senior convertible debt                                                            5,799,000                   ---
                                                                             ---------------             --------------

Total liabilities                                                                 12,195,000                16,178,000

Minority interest                                                                    622,000                 2,574,000

Senior convertible redeemable preferred stock, Series C                            4,025,000                 4,344,000

Stockholders' equity Preferred stock, $.001 par value:
         Authorized shares--2,000,000
         Issued--none (unaudited in 1998)                                                ---                       ---
     Non-voting common stock, convertible on disposition
         into voting common stock, $.0075 par value:                     
         Authorized shares--1,000,000 shares                             
         Issued and outstanding shares--395,000 (unaudited
              in 1998)                                                                 3,000                     3,000
     Common stock, $.0075 par value:
         30,000,000  shares  authorized at September 30, 1998 19,000,000  shares
         authorized in 1997; 16,688,632 shares issued in 1998 (unaudited);
         13,134,021 in 1997                                                          125,000                    98,000
     Additional paid-in capital                                                   57,502,000                50,833,000
     Deficit                                                                    (39,403,000)              (40,998,000)
     Treasury stock--1,345,236 shares in 1998 (unaudited);
         218,838 shares in 1997                                                  (4,442,000)               (2,674,000)
                                                                             ---------------            --------------
Total stockholders' equity                                                       13,785,000                 7,262,000
                                                                              --------------            -------------
Total liabilities and stockholders' equity                                     $ 30,627,000               $30,358,000 
                                                                               =============              ============

</TABLE>

                             See accompanying notes

                                        4

<PAGE>


<TABLE>
<CAPTION>

                           NaPro BioTherapeutics, Inc.

                             Statement of Operations
                                   (Unaudited)


                                                        Three Months Ended                     Nine Months Ended
                                                           September 30,                         September 30,
                                                      1998               1997               1998               1997
                                                     ------             ------             ------             -----

<S>                                                 <C>                <C>                  <C>                 <C>

Product sales                                       $     732,000      $     879,000        $ 3,721,000         $ 1,978,000

Expense:
     Research, development and cost
         of products sold                               2,089,000          2,602,000          6,775,000           7,629,000
     General and administrative                         1,044,000          1,382,000          5,131,000           4,654,000
     (Gain) Loss on retirement
         of assets                                        581,000            ---                582,000            (218,000)
                                                    -------------  -----------------     --------------       -------------
                                                        3,714,000          3,984,000         12,488,000          12,065,000
                                                     ------------       ------------       ------------        -----------

Operating loss                                         (2,982,000)        (3,105,000)        (8,767,000)        (10,087,000)

Other income (expense):
     License fee                                        2,950,000                ---         10,770,000                 ---
     Interest income                                      150,000            119,000            413,000             407,000
     Interest and other expense                          (248,000)          (935,000)          (821,000)         (1,309,000)
                                                    -------------      -------------      -------------       -------------
Net income (loss)                                   $    (130,000)       $(3,921,000)        $1,595,000        $(10,989,000)
                                                    =============       ============        ===========       =============

Earnings (loss) per share                         $        (0.01)     $       (0.33)     $        0.10      $        (0.92)
                                                  ===============     ==============     ==============     ===============

Earnings (loss) per common share,
     assuming dilution                            $        (0.01)     $       (0.33)     $        0.09      $        (0.92)
                                                  ===============     ==============     ==============     ===============
Weighted average shares outstanding                   14,949,422         12,055,344         14,196,179          11,994,855
                                                     ============       ============       ============        ===========
Weighted average shares outstanding,
     assuming dilution                                14,949,422         12,055,344         16,807,660          11,994,855 
                                                     ============       ============       ============        ============


</TABLE>





                             See accompanying notes.

                                        5

<PAGE>


<TABLE>
<CAPTION>

                           NaPro BioTherapeutics, Inc.

                               Cash Flow Statement
                                   (Unaudited)

                                                                                          Nine Months Ended
                                                                                            September 30,
                                                                                        1998               1997
                                                                                       ------              -----
<S>                                                                                    <C>                 <C>
Operating activities
Net income (loss)                                                                      $1,595,000          $(10,989,000)
Adjustments to reconcile net income (loss) to net cash
     provided (used) by operating activities:
     Depreciation                                                                       1,894,000               559,000
     Accretion of debt issue cost, warrant allocation
         and conversion rights allocation                                                 331,000               845,000
     Compensation paid with warrants                                                      139,000                   ---
     Interest paid in stock                                                               290,000                   ---
     (Gain) loss on sale or retirement of assets                                          582,000              (218,000)
     Loss on early retirement of debt                                                     127,000                   ---
     Changes in operating assets and liabilities:
         Accounts receivable                                                            1,079,000               207,000
         Inventory                                                                       (781,000)           (2,744,000)
         Prepaid expense and other assets                                                 109,000               (10,000)
         Accounts payable                                                              (2,897,000)            3,097,000
         Accrued liabilities                                                               61,000               240,000
         Deferred revenue                                                               1,779,000               525,000
                                                                                      -----------       ---------------
Net cash provided (used) by operating activities                                        4,307,000            (8,488,000)
Investing activities
     Transfers to restricted cash                                                      (2,000,000)           (7,299,000)
     Transfers from restricted cash                                                       391,000             4,888,000
     Additions to property and equipment                                                 (550,000)           (9,431,000)
     Proceeds from the sale of property and equipment                                      40,000               361,000
     Purchase of securities held to maturity                                                  ---            (3,827,000)
     Proceeds from securities available for sale                                              ---             2,650,000
     Proceeds from securities held to maturity                                            ---                 6,476,000
                                                                              --------------------         ------------
Net cash used by investing activities                                                  (2,119,000)           (6,182,000)
Financing activities
     Proceeds from notes payable                                                          188,000            11,045,000
     Debt issue cost                                                                          ---              (745,000)
     Payments under notes payable                                                      (1,385,000)           (1,786,000)
     Proceeds from the sale of common stock,
         and exercise of common stock warrants                                             42,000             1,172,000
                                                                                   --------------         -------------
Net cash provided (used) by financing activities                                       (1,155,000)            9,686,000
                                                                                     ------------         -------------
Net increase (decrease) in cash and cash equivalents                                    1,033,000            (4,984,000)
Cash and cash equivalents at beginning of period                                        8,102,000             9,531,000
                                                                                    -------------         ------------
Cash and cash equivalents at end of period                                            $ 9,135,000           $ 4,547,000 
                                                                                     ============          ============
</TABLE>

                             See accompanying notes.

                                        6

<PAGE>



                                            NaPro BioTherapeutics, Inc.

                                    Notes to Consolidated Financial Statements
                                                September 30, 1998
                                                    (Unaudited)

1.       Basis of Presentation

The accompanying financial statements are unaudited.  However, in the opinion of
management, the financial statements reflect all adjustments, consisting of only
normal recurring adjustments,  necessary for fair presentation.  Interim results
of operations are not indicative of results for the full year.  These  financial
statements  should be read in  conjunction  with the NaPro Annual Report on Form
10-K for the year ended December 31, 1997.

2.       Inventory                      September 30,              December 31,
                                          1998                      1997      

         Raw materials                    $   120,000               $   412,000
         Work-in-process                    1,472,000                 1,408,000
         Finished goods                     2,579,000                 1,302,000
                                           ----------               -----------
                                           $4,171,000                $3,122,000
                                           ==========                ==========

         Non-current inventory

         Raw materials                    $   468,000               $   347,000
         Work-in-process                      440,000                   288,000
         Finished goods                      ---                        541,000
                                          -----------               -----------
                                             $908,000                $1,176,000
                                             ========                ==========

3.       Cash Flow Supplemental Disclosures
                                                            Nine Months Ended
                                                            September 30,
                                                    1998               1997   
                                                -----------       ------------

Interest paid                                   $    380,000       $    469,000

Noncash transactions:
Receipt of common stock into treasury:
     Note 4                                        1,768,000              ---
Repayment of notes receivable from stockholder
     through transfer of stock into treasury            ---             990,000
Issuance of common stock--compensation                40,000             40,000
     Exchange of preferred shares of subsidiary
     for common stock of parent                    1,951,000              ---
Conversion of senior convertible debt to  
     common stock                                  2,141,000              ---



                                        7

<PAGE>



Cash Flow Supplemental Disclosures
     (Continued)                                            Nine Months Ended
                                                            September 30,
                                                    1998               1997     
                                                --------------    --------------

Conversion of convertible preferred shares
     to common stock                                 639,000             ---
Accretion of convertible preferred stock
     conversion rights valuation, offering
     cost and warrant valuation                      323,000             ---
Issuance of common stock for dividends payable       182,000             ---
Note taken as partial proceeds on sale of asset         ---             578,000

4.       Common Stock

In the  September  1998 quarter NaPro issued  596,073  shares of common stock in
conversion of NaPro's senior convertible debt, and 66,314 shares of common stock
in payment of  interest on the senior  convertible  debt.  In the quarter  NaPro
issued   220,538  shares  of  common  stock  in  conversion  of  NaPro's  senior
convertible  preferred  stock and  48,322  shares of common  stock in payment of
dividends on the senior convertible preferred stock.

5.       Asset realization; loss on retirement of assets

NaPro focuses on the development,  manufacture and  commercialization of natural
product   pharmaceuticals,   particularly   paclitaxel,  a  naturally  occurring
cancer-fighting  compound  found in certain  species of yew (Taxus)  trees.  The
nature of  pharmaceutical  development  work includes the acquisition of assets,
the  realization  of which may be  dependent  on approval by various  regulatory
agencies,  such as the United States Food and Drug Administration,  of developed
products for sale. NaPro currently sells commercial  paclitaxel to F.H. Faulding
& Co.,  Ltd., an Australian  corporation,  which has approvals for paclitaxel in
Australia and 11 other countries.  The full realization of NaPro's assets may be
dependent  on  approval  of NaPro  paclitaxel  in  either  the U.S.  or  Europe.
Management believes that its assets bear no impairment at this time.

 NaPro  temporarily  suspended  construction  of  its  commercial  manufacturing
facility in Boulder, Colorado. As a result of this suspension NaPro has incurred
cost on certain  elements of  construction  in progress.  Accordingly  NaPro has
disposed  or will  dispose of such  assets  and has  expensed  the cost,  net of
estimated  salvage.  Development  continues on the  manufacturing  process to be
installed in this  facility.  Improvements in the manufacturing  process arising
from such  development  may result in  disposal of  additional  assets at future
dates.  No  determination  can  presently  be made of the amount of such  future
disposals, if any.

6.       Earnings (loss) per Share

The following  table sets forth the  computation  of basic and diluted  earnings
(loss) per share. In calculating diluted earnings (loss) per share for the three
periods  in which a loss is  reported,  the impact of all  additional  shares is
antidilutive, and thus not included in the calculation:

                                        8

<PAGE>

<TABLE>
<CAPTION>




                                                              Quarter Ended                     Nine Months Ended
                                                              September 30,                       September 30,
                                                          1998             1997              1998               1997
                                                         ------           ------            ------             -----
Numerator:
   <S>                                                   <C>              <C>                <C>              <C>

   Net income (loss)                                     $ (130,000)      $(3,921,000)       $ 1,595,000      $(10,989,000)
   Preferred stock dividends                                (56,000)          ---               (182,000)            ---
                                                          ----------  ----------------      ------------    --------------
   Numerator for earnings (loss) per
      share - income (loss) available to
      common stockholders                                $ (186,000)      $(3,921,000)         1,413,000      $(10,989,000)

Effect of dilutive securities:
   Senior convertible debt                                  ---               ---                50,000            ---
   Preferred stock dividends                                ---               ---                27,000            ---
                                                    ----------------  ----------------     -------------       -----------
   Numerator for earnings (loss) per share, assuming dilution - income available
      to common stockholders after assumed
     conversions                                       $   (186,000)      $(3,921,000)      $ 1,490,000       $(10,989,000)
                                                         ===========      ============      ============      =============

Denominator:
   Denominator for earnings (loss) per share -
        weighted average shares outstanding              14,949,422        12,055,344        14,196,179          11,994,855
                                                         -----------      ------------      ------------         ----------
   Senior convertible debt                                  ---               ---             1,371,339            ---
   Convertible preferred stock                              ---               ---               796,996            ---
   Non-voting common stock                                  ---               ---               395,000            ---
   Stock options and warrants                               ---               ---                48,146            ---
                                                    ----------------  ----------------     -------------        -----------
Dilutive potential common shares                            ---               ---             2,611,480            ---
                                                    ----------------  ----------------       -----------        -----------
   Denominator  for  earnings  (loss) per  share,  assuming  dilution - adjusted
        weighted average shares outstanding and assumed
        conversions                                      14,949,422        12,055,344        16,807,660          11,994,855
                                                         -----------      ------------       ===========         ==========
Earnings (loss) per common share                      $       (0.01)    $       (0.33)    $        0.10       $      (0.92)
                                                      ==============    ==============    ==============      =============
Earnings (loss) per common share, assuming
    dilution                                          $       (0.01)    $       (0.33)    $        0.09       $      (0.92)
                                                      ==============    ==============    ==============      =============
</TABLE>

Item 2.  Management's Discussion and Analysis of Financial Condition and Results
         of Operations

The  following   discussion  and  analysis  provide   information  that  NaPro's
management  believes is  relevant  to an  assessment  and  understanding  of the
Company's results of operations and financial condition.  This discussion should
be read in  conjunction  with the  consolidated  financial  statements and notes
thereto  appearing  elsewhere herein as well as with the consolidated  financial
statements,  notes thereto and the related management's  discussion and analysis
of financial  condition  and results of  operations  included in NaPro's  Annual
Report on Form 10-K for the year ended December 31, 1997.

General

NaPro is a natural product  pharmaceutical company that is focusing primarily on
the   development,   manufacture   and   commercialization   of  paclitaxel,   a
naturally-occurring  anti-cancer  agent found in certain  species of yew (Taxus)
trees.


                                        9

<PAGE>



NaPro has devoted its efforts primarily to the development and implementation of
its proprietary  extraction,  isolation and purification  (EIPTM) technology and
the  development of its proprietary  semi- synthetic  method for producing NaPro
paclitaxel.   To  advance  the  development  and   commercialization   of  NaPro
paclitaxel,  NaPro entered into a 20-year,  geographically  exclusive  agreement
with F.H. Faulding & Co., Ltd. ("Faulding") for the clinical development, sales,
marketing and distribution of NaPro  paclitaxel.  NaPro is in discussions with a
number of pharmaceutical  companies,  both domestically and internationally,  to
assist NaPro in developing  and marketing  NaPro  paclitaxel in various parts of
the world.  NaPro is currently  dependent  for revenue  exclusively  on sales of
NaPro paclitaxel, and on fee income from licensed technology.

NaPro  has  initiated  clinical  studies  exploring  the  use  of  its  patented
formulation of paclitaxel  using its patented  method of  administration.  NaPro
anticipates that information gained in such studies will be useful in the filing
of a New Drug Application with the U. S. Food and Drug  Administration for NaPro
paclitaxel.  The cost of such  studies is and will  continue to be  significant.
NaPro  anticipates  that  should  it enter  into an  agreement  with one or more
pharmaceutical  companies as  discussed  above,  such  agreement  would  include
funding for all or a significant  portion of the related  clinical studies cost.
Absent such an agreement or other  financing of these  studies,  the cost of the
clinical studies may significantly reduce NaPro's working capital.

Through September 30, 1998,  NaPro's  production of NaPro paclitaxel was limited
primarily to research and  pilot-scale  production,  and much of NaPro's product
sales were for use in clinical trials and for research and development purposes.
Accordingly,  NaPro has generated only limited  revenue from such activities and
has incurred significant losses, including losses of approximately $4.1 million,
$6.8 million and $15.5 million for the years ended  December 31, 1995,  1996 and
1997,  respectively.  For the nine months ended September 30, 1998, largely as a
result of a nonrecurring  license fee received from IVAX Corporation (IVAX) (see
below), NaPro recorded net income of approximately $1.6 million, resulting in an
accumulated  deficit of $39.4  million as of September  30, 1998.  NaPro expects
that it will  continue  to have a high level of  operating  expense  and will be
required  to make  significant  up-front  expenditures  in  connection  with its
biomass  procurement,   product   development,   and  research  and  development
activities.  NaPro anticipates that annual losses will continue until such time,
if  ever,  as  NaPro is able to  generate  sufficient  revenue  to  support  its
operations.  NaPro  believes that its ability to generate  such revenue  depends
primarily on its ability to obtain  regulatory  approval in the U. S. or another
major market for the commercial sale of NaPro paclitaxel,  on NaPro's ability to
obtain one or more  partners  to  replace  IVAX,  on  NaPro's  ability to obtain
regulatory  approval for its manufacturing  facilities and on NaPro's ability to
construct  manufacturing  facilities that produce quantities of NaPro paclitaxel
sufficient to supply NaPro's  strategic  partners'  requirements  for commercial
sales.  Moreover,  NaPro's  future growth and  profitability  will depend on the
success of its strategic  partners in fostering  acceptance  in the  oncological
market for NaPro paclitaxel as a preferred dosing regimen of taxane chemotherapy
to be used alone or in combination with other chemotherapeutic agents.

In February  1998,  due to the delay in receiving  marketing  approval for NaPro
paclitaxel,  NaPro underwent a restructuring to decrease overall cost, resulting
in a  one-time  charge  of  approximately  $250,000.  NaPro's  total  number  of
employees was reduced by 53, a 43% reduction in full time  positions,  resulting
in an expected annual savings of $2.8 million in payroll  expense.  This payroll
expense is  reflected  in  research  and  development,  as well as  general  and
administrative  expense.  In addition,  nonpayroll  expense is also  expected to
decrease as the result of the restructuring.  As part of the restructuring NaPro
temporarily  closed its British  Columbia  manufacturing  facility and suspended
construction  of  its  commercial  scale  manufacturing   facility  in  Boulder,
Colorado. Completion of the

                                        10

<PAGE>



Boulder facility will require additional financing,  which NaPro intends to seek
at such time, if ever, as NaPro anticipates sufficient product demand to warrant
completion of the facility.

In March  1998,  NaPro  and  IVAX  entered  into an  agreement  terminating  the
development and marketing  activity between the two companies (the  "Termination
Agreement").  Under the terms of the  Termination  Agreement,  IVAX  received  a
royalty-free, limited, nonexclusive license to one of NaPro's pending patents in
the U. S., Europe, and certain other world markets. In return,  NaPro received a
cash  payment  of $6  million,  $2  million  of which was placed in escrow to be
released as remaining product is delivered  through March 1999.  Revenue related
to the  escrow  funds has been  deferred  and is to be  recognized  as funds are
released from the escrow. In addition, IVAX returned in April 1998 approximately
1.1 million  shares of NaPro common stock and made  additional  payments of $3.8
million  in April  1998 and $2.6  million  in  August  1998.  Of the $2  million
escrowed  funds,  $340,000 was released in August 1998.  NaPro will  continue to
manufacture a fixed amount of NaPro paclitaxel for IVAX to be delivered and paid
for through March 1999.

The Termination  Agreement  leaves NaPro free to seek  regulatory  approvals and
market NaPro  paclitaxel  itself or to seek a new partner or partners with which
to pursue regulatory approvals and marketing of NaPro paclitaxel, in either case
outside  the  territory  contractually  allocated  to  Faulding.   However,  the
Termination  Agreement currently leaves NaPro without such a partner.  There can
be no  assurance  that NaPro will be able to secure such  approvals  or form new
long-term relationships for the approval,  marketing,  and distribution of NaPro
paclitaxel in these areas,  or that NaPro or such a partner,  if found,  will be
able to effectively market NaPro paclitaxel.

Year 2000 issue

Until recently many computer  programs used only the last two digits to refer to
a year.  Such  programs do not  properly  recognize a year that begins with "20"
instead of the familiar "19". If not corrected, many computer applications could
fail or create  erroneous  results.  This matter is commonly  referred to as the
Year 2000 issue or Y2K.

Two years ago NaPro  implemented  an  assessment of its systems and other assets
which could be subject to Y2K. NaPro has completed the assessment of its primary
systems  and has  brought  all but one of the  systems  into Y2K  compliance.  A
compliant  upgrade currently exists for the noncompliant  system,  which will be
brought  into  compliance  no later  than April  1999.  NaPro is  assessing  its
secondary  systems and other assets and expects to complete  that  assessment no
later than April 1999.

NaPro is assessing its secondary  systems,  including  microprocessor-controlled
equipment.  The potential for significant  interruption  from secondary  systems
exists,  although NaPro believes that the likelihood of  interruption  caused by
Y2K failures in secondary systems is quite small.

In addition to its internal  systems  NaPro is  evaluating  potential  impact on
NaPro of Y2K issues  with its  vendors  and  customers.  NaPro  cannot  directly
control Y2K compliance by its vendors and customers. NaPro is communicating with
its key vendors and customers regarding this matter. NaPro knows of no vendor or
customer  that has Y2K issues that have a potential of  interrupting  NaPro in a
manner that could significantly affect NaPro's operations. However, NaPro uses a
number of  vendors  that  NaPro  believes  to be the best or the only  qualified
source of a particular good or service.  Sales to NaPro's customers  potentially
could be  interrupted  by  customers'  Y2K issues.  For example,  NaPro's  sales
process  involves  sample  testing by customers  prior to customers'  release to
NaPro for product shipment. Should a

                                       11

<PAGE>



significant  customer  incur Y2K  problems  with its  testing,  release or other
systems,  NaPro's  sales could be  materially  affected.  NaPro will continue to
monitor  the  level  of Y2K  compliance  with  respect  to its key  vendors  and
customers and will further develop  contingency  plans to cover the failure of a
key vendor, including identification and qualification of alternative suppliers.
Management  believes that  exposure to vendor or customer Y2K issues  creates no
material risk to NaPro.  However,  no assurance can be given with certainty that
Y2K issues with vendors or customers will not significantly affect NaPro.

NaPro's  Y2K effort  has caused no  significant  deferral  of other  information
technology projects.

NaPro's  Y2K  contingency  plan  includes   completion  of  the  evaluation  and
remediation  process  discussed  above,  including  communication  with  its key
vendors and customers regarding potential for Y2K issues;  identification of the
best  alternative  vendor for  sensitive  goods and services;  coordination  and
planning with such alternative vendors.

Management  believes  that Y2K issues  related  to both  internal  and  external
systems will have no material effect on NaPro's business,  results of operations
or financial condition,  and that NaPro's Y2K risk is not material.  However, no
such assurance can be given with  certainty.  The cost of addressing Y2K has not
been  material;  management  believes that the cost of completing Y2K compliance
will not be material.

Results of Operations

Quarter ended  September 30, 1998,  compared to the quarter ended  September 30,
1997 Sales for the 1998  quarter  were  $700,000,  representing  a  decrease  of
$200,000 from the 1997 quarter.  The decrease related primarily to the timing of
product shipments. Shipments to the strategic partners may vary significantly on
a quarter to quarter basis depending on a number of factors including the timing
and size of any clinical trials conducted by the strategic  partners,  the level
of inventory  carried by the strategic  partners,  NaPro's obtaining one or more
partners   to  replace   IVAX,   and   changes   in   approved   markets.   This
quarter-to-quarter  variability  will continue  until such time,  if ever,  that
stable commercial demand has been established for the product in a major market.

Research and  development and cost of products sold expense for the 1998 quarter
was $2.1 million, representing a decrease of $500,000 from the 1997 quarter. The
decrease  resulted  from a  decrease  in the level of  process  development  and
research  expense  as well as  lower  production  cost.  At  this  time  NaPro's
production process is not distinct from its research and development  processes.
Accordingly,  the cost of products  sold is included  with NaPro's  research and
development expense.

General  and  administrative  expense for the 1998  quarter  was $1  million,  a
decrease  of  $400,000  from  the  1997  quarter.   The  decrease  is  primarily
attributable  to an overall  decrease  in the level of  resources  committed  to
general  and  administrative  activity  as a result  of  NaPro's  February  1998
restructuring.

Loss on retirement of assets for the 1998 quarter was $600,000,  with no loss in
the 1997 quarter.  NaPro  temporarily  suspended  construction of its commercial
manufacturing  facility in  Boulder,  Colorado.  As a result of this  suspension
NaPro has  incurred  cost on  certain  elements  of  construction  in  progress.
Accordingly  NaPro has  disposed or will dispose of such assets and has expensed
the cost, net of estimated salvage.  Development  continues on the manufacturing
process to be installed in this  facility.  Improvements in the  manufacturing
process  arising  from such  development  may result in disposal  of  additional
assets at future dates. No determination  can presently be made of the amount of
such future disposals, if any.

                                       12

<PAGE>



License fee income for the 1998  quarter was $3 million.  There was no analogous
income for the 1997 quarter.  This revenue related to a license fee paid by IVAX
in conjunction with the Termination Agreement.  Under the Termination Agreement,
NaPro expects to record up to an  additional  $1.7 million in license fee income
through  March  1999 (all of which has been  received  but is  escrowed  pending
future  product  deliveries).   NaPro  is  actively  seeking  one  or  more  new
pharmaceutical  partners to replace IVAX.  There can be no  assurance,  however,
that NaPro will  succeed in  obtaining  any new  pharmaceutical  partners  or in
earning  any  license  fees  other  than the  license  fee being  paid under the
Termination Agreement.

Interest income for the 1998 quarter was $200,000,  virtually unchanged from the
1997 quarter.

Interest  and other  expense for the 1998  quarter was  $200,000,  a decrease of
$700,000 from the 1997 quarter. This decrease is primarily due to the absence of
significant amortization of discount related to the conversion rights of NaPro's
senior convertible debt.

Nine  months  ended  September  30,  1998,  compared  to the nine  months  ended
September 30, 1997 Sales for the 1998 period were $3.7 million , representing an
increase of $1.7 million from the 1997 period. The increase related primarily to
the timing of product shipments.

Research and  development  and cost of products sold expense for the 1998 period
was $6.8 million,  representing a decrease of $800,000 from the 1997 period. The
decrease  resulted  from a  decrease  in the level of  process  development  and
research expense as well as lower production cost.

General and  administrative  expense for the 1998  period was $5.1  million,  an
increase  of  $400,000   from  the  1997  period.   The  increase  is  primarily
attributable to the cost associated with the IVAX termination, the February 1998
restructuring, and depreciation.

Loss on retirement of assets for the 1998 period was  $600,000,  representing  a
change of $800,000 from the $200,000 gain in the 1997 period.  NaPro temporarily
suspended  construction  of its  commercial  manufacturing  facility in Boulder,
Colorado.  As a result of this  suspension  NaPro has  incurred  cost on certain
elements of  construction  in progress.  Accordingly  NaPro has disposed or will
dispose of such assets and has  expensed  the cost,  net of  estimated  salvage.
Development  continues  on the  manufacturing  process to be  installed  in this
facility; such development may result in disposal of additional assets at future
dates.  No  determination  can  presently  be made of the amount of such  future
disposals, if any.

License  fee  income  for the 1998  period was $10.8  million.  NaPro  earned no
analogous income for the 1997 period. This revenue related to a license fee paid
by IVAX in conjunction with the Termination Agreement.

Interest  income  for the 1998  period  was  $400,000,  unchanged  from the 1997
period.

Interest  and other  expense for the 1998 period was  $800,000,  representing  a
decrease of $500,000 from the 1997 period. This decrease is primarily due to the
absence of significant amortization of discount related to the conversion rights
of NaPro's senior convertible debt.

Liquidity and Capital Resources


                                       13

<PAGE>



NaPro's capital  requirements have been and will continue to be significant.  At
September 30, 1998, NaPro had working capital of $9.6 million.  This compared to
negative  working  capital of $2.5 million at December 31,  1997.  To date,  the
funding of NaPro's capital  requirements has been dependent primarily on the net
proceeds of public offerings of its common stock of approximately $21.1 million,
on private  placements of its equity securities of approximately  $27.8 million,
on the exercise of warrants and options of $5.6  million,  on net  borrowings of
$11.8  million,  and on loans and advances from its  stockholders  and strategic
partners.

In June and December 1997, NaPro issued its Senior Convertible Notes due in 2000
(the "Convertible Notes") and Series C Senior Convertible  Preferred Stock (the"
Convertible  Preferred  Stock"),  respectively.  The Convertible  Notes and the
Convertible Preferred Stock are referred to as the "Convertible Securities."

The Convertible Securities can be converted into NaPro common stock at discounts
(ranging  from 5% to 10%)  from the  market  price of the  common  stock  during
specified periods prior to the conversion,  subject to a maximum of $1.92385 per
share of common stock. Such conversions may be made at the rate of up to 450,000
shares of common stock per month through  December 31, 1998,  and up to the full
amount of the outstanding Convertible Securities thereafter. As of September 30,
1998,  $3.8  million of the  Convertible  Securities  have been  converted  into
2,965,666  shares of common stock.  After  September 30, 1998,  over 5.6 million
shares  of  common  stock  could be  issued  by  NaPro  upon  conversion  of the
Convertible  Securities  subject to certain  limitations  under the terms of the
Convertible  Securities.  The issuance of shares of common stock upon conversion
of the  Convertible  Securities  would  result in  substantial  dilution  of the
interest of the current  stockholders of NaPro.  NaPro is evaluating  options to
refinance or redeem the Convertible Securities in circumstances where the number
of shares of common stock issued in connection therewith would be limited to the
extent practicable. NaPro is considering various sources of capital to fund such
a transaction,  including  possible funding from a potential  strategic partner.
NaPro can give no  assurance  that any such  transaction  or  transactions  will
occur.

Cash and cash equivalents totaled $9.1 million at September 30, 1998. During the
first nine months of 1998,  cash provided by operating  activities  totaled $4.3
million;  and cash used by  investing  and  financing  activities  totaled  $2.1
million and $1.2 million, respectively.

The amount and timing of future capital  expenditures  will depend upon numerous
factors including the progress of NaPro's research and development  program, the
magnitude and scope of these activities;  competing  technological and marketing
developments;  changes in the existing strategic partnership;  the establishment
of  additional  strategic  relationships;  the cost of further  development  and
maintenance of Yew tree  plantations;  and the cost of  manufacturing  scale-up.
NaPro may seek  additional  long-term  financing  to fund  capital  expenditures
should such financing become available on terms acceptable to NaPro.

                                       14

<PAGE>



Special Note Regarding Forward-looking Statements.

Certain statements in this report constitute "forward-looking statements" within
the meaning of the federal securities laws. In addition, NaPro or persons acting
on its behalf  sometimes  make  forward-looking  statements in other written and
oral communications.  Such forward-looking  statements may include,  among other
things,  statements  concerning  NaPro's plans,  objectives and future  economic
prospects,  such as matters relative to seeking and obtaining strategic partners
and the consequences  thereof; the refinancing or redemption of the Convertible
Securities; the availability of patent and other protection for its intellectual
property;  the  completion  of  clinical  trials  and  regulatory  filings;  the
prospects for and timing of regulatory approvals;  the need for and availability
of additional capital; the amount and timing of capital expenditures;  timing of
products introductions and revenue; the availability of raw materials; prospects
for future  operations;  and other statements of expectations,  beliefs,  future
plans and  strategies,  anticipated  events or trends  and  similar  expressions
concerning  matters  that  are  not  historical  facts.  Such  for  ward-looking
statements  involve  known and unknown  risks,  uncertainties  and other factors
which may cause the actual  results,  performance or  achievements  of NaPro, or
industry  results,   to  be  materially   different  from  any  future  results,
performance  or  achievements  expressed  or  implied  by such for  ward-looking
statements.  Included,  among other things, are the following  factors:  adverse
economic and general business conditions,  competition from Bristol-Myers Squibb
Company  (Bristol) and other  existing and new producers of paclitaxel and other
drugs,  technological  advances in cancer  treatment and drug  development,  the
ability to obtain  rights to  technology,  the  ability  to obtain  and  enforce
patents,  the ability to obtain raw  materials and  commercialize  manufacturing
processes,  the  effectiveness  of NaPro  paclitaxel  and other  pharmaceuticals
developed by NaPro in treating  disease,  the results of clinical  studies,  the
results of research  and  development  activities,  the business  abilities  and
judgment  of  NaPro's  management  and  other  personnel,  the  availability  of
qualified  personnel  generally,  changes in and  compliance  with  governmental
regulations,  the  effect of  capital  market  conditions  and other  factors on
capital  availability  for  NaPro  and other  biopharmaceutical  companies,  the
ability of Faulding to perform its obligations under its existing agreement with
NaPro, the ability of NaPro to establish  relationships  with capable  strategic
partners to develop and market NaPro  paclitaxel in the  territories not covered
by the Faulding Agreement, and other factors referenced in this Report.

Item 3.  Quantitative and Qualitative Disclosures about Market Risk.  

         Not applicable.


                           Part II--Other Information

Item 1.  Legal Proceedings

Australian Petty Patents

In September 1993 and August 1994, Bristol received two Australian petty patents
claiming certain methods of administering  paclitaxel.  Australian petty patents
have a maximum term of six years. Such patents are allowed to contain only three
claims (one  independent  and two  dependent)  and are granted on the basis of a
prior art search, which is significantly more limited in scope than the searches
done prior to issuance  of  standard  patents.  Following  publication  of these
patents, Faulding instituted legal action to revoke these patents on the grounds
that the patent  claims are invalid and that the subject  matter  claimed in the
patents was already  known prior to the claimed date of  invention.  In February
1995,  Bristol  brought legal action  against  Faulding  based upon these patent
claims,  seeking  an  injunction  against  Faulding  to  prevent  Faulding  from
marketing NaPro paclitaxel pursuant to Faulding's generic approval.

                                       15

<PAGE>



In July 1998,  Faulding  received a favorable  ruling from the Federal  Court in
Australia that  invalidated  the patents.  In addition,  the court ruled against
Bristol in the countersuit which alleged infringement of those patents.

European Patent Litigation

On May 14,  1997,  Bristol  was issued a  European  patent  relating  to certain
methods  of  treatment  with  paclitaxel.  On the  same  day,  NaPro  instituted
revocation  proceedings  in the United Kingdom  against this European  patent as
issued in the U. K. The revocation  action was not in response to any lawsuit or
allegations of infringement  against NaPro relating to the patents,  but Bristol
has subsequently  instituted a countersuit against NaPro alleging  infringement.
The court heard each of the party's  claims in July 1998. On August 25, 1998 the
court ruled in favor of NaPro that the patent was invalid in the United Kingdom.
Bristol has filed notice that it intends to appeal the decision.

Item 2.  Changes in Securities

In the September  1998 quarter,  NaPro issued  596,073 shares of common stock in
conversion  of $644,000  of the  Convertible  Notes and 66,314  shares of common
stock in payment of $82,000  interest on the Convertible  Notes. In the quarter,
NaPro issued  220,538  shares of common stock in conversion of 254 shares of the
Convertible  Preferred  Stock and  48,322  shares of common  stock in payment of
$55,000 of dividends on the Convertible  Preferred Stock. The issuance of shares
of common stock upon  conversion of the  Convertible  Securities was exempt from
registration  under section  3(a)(9) of the  Securities  Act of 1933, as amended
(the "Securities Act"). The issuance of shares of common stock in the payment of
interest  and  dividends  was  exempt as a private  placement  to  sophisticated
investors under section 4(2) of the Securities Act and Regulation D thereunder.



Certain  provisions of the Convertible  Preferred Stock may limit the ability of
NaPro to pay  dividends  on its  common  stock and to  repurchase  shares of its
common stock.

Item 3.  Defaults upon Senior Securities.     None.

Item 4.  Submission of Matters to a Vote of Securities Holders.   None.

Item 5.  Other Information.  None.



                                       16

<PAGE>



Item 6.  Exhibits and Reports on Form 8-K

NaPro filed no Current Reports on Form 8-K during the quarter.
<TABLE>
<CAPTION>

Exhibit
Number        Description of Exhibit
<S>           <C>

10.1          Employment Agreement effective October 5, 1998 between NaPro and Leonard P. Shaykin
10.2          Employment Agreement effective October 5, 1998 between NaPro and Sterling K. Ainsworth
10.3          Employment Agreement effective October 5, 1998 between NaPro and Patricia A. Pilia
10.4          Employment Agreement effective October 5, 1998 between NaPro and Gordon Link
10.5          Employment Agreement effective October 5, 1998 between NaPro and David L. Denny
10.6          Employment Agreement effective October 5, 1998 between NaPro and William D. Fairbairn
10.7          Employment Agreement effective October 5, 1998 between NaPro and James D. McChesney
27.1          Financial Data Schedule
</TABLE>

- -------------------------------

Signatures

Pursuant to the  requirements of the Securities  Exchange Act of 1934, NaPro has
duly caused this report to be signed on its behalf.

                                      NaPro BioTherapeutics, Inc.


November 11, 1998                     /s/ Sterling K. Ainsworth

                                      Sterling K. Ainsworth
                                      President and Chief Executive Officer
                                      (Principal Executive Officer)


November 11, 1998                     /s/ Gordon Link

                                      Gordon Link
                                      Vice President and Chief Financial Officer
                                      (Principal Financial Officer)


November 11, 1998                     /s/ Robert L. Poley

                                      Robert L. Poley
                                      Controller
                                      (Principal Accounting Officer)


                                       17

<PAGE>





                          AMENDED EMPLOYMENT AGREEMENT

         THIS AGREEMENT (the "Agreement") is entered into effective this 5th day
of October,  1998 (the "Effective Date"), by and between NaPro  BioTherapeutics,
Inc.,  a  Delaware   corporation  (the   "Company"),   and  Leonard  P.  Shaykin
("Executive"). Certain capitalized terms used in this Agreement have the meaning
set forth in Paragraph 17 hereof.

                                    RECITALS

         A. WHEREAS,  the Company and the Executive have previously entered into
an Amended and Restated  Employment and Executive Stock  Agreement,  dated as of
June 7, 1993 and amended and restated  effective as of May 31, 1994, (the "Prior
Agreement"); and

         B. WHEREAS,  the Company  desires to secure the  continued  services of
Executive as an employee of the Company, and to provide for certain compensation
and benefit  arrangements for Executive in the event of Executive's  termination
of  employment  under certain  circumstances,  and Executive is willing to enter
into this Agreement and perform such services.

                              TERMS AND CONDITIONS

         In  consideration  of the  respective  covenants and  agreements of the
parties  contained in this Agreement,  the parties agree to amend and restate in
its entirety the Prior Agreement as follows:

         1. Employment Services.  The Company hereby agrees to engage Executive,
and Executive  hereby agrees to perform  services for the Company,  on the terms
and conditions  set forth in this  Agreement.  During the Employment  Period (as
defined  below),  the Company and Executive  agree that  Executive will serve as
Chairman  of  the  Board  of   Directors   of  the  Company   with  the  duties,
responsibilities  and  authority  as set forth on  Schedule A, or will have such
other  executive  title and such other executive  duties,  responsibilities  and
authority  as  Executive  and the Company may agree upon from time to time,  and
will perform such services of an executive and  administrative  character to the
Company and its present or future Subsidiaries consistent with the duties of the
Company's  other  executive  officers,  as the Company's Board of Directors (the
"Board") may from time to time direct (the "Employment  Services") or the Bylaws
of the Company may provide.  The  Employment  Services  shall  commence upon the
Effective  Date of this  Agreement and terminate as provided in Paragraph 6 (the
"Employment Period").

         2.       Performance.

                  (a) Executive  shall report to the Board,  and Executive shall
devote such business time as he and the Company  reasonably believe is necessary
to perform the  Employment  Services  (except for permitted  vacation  periods);
provided,  however, that (i) Executive shall be free to devote his business time
to perform and engage in other  businesses  not  inconsistent  with the terms of
this Agreement;  and (ii) Executive shall not, without his consent,  be required
to devote more than 20 hours in any week or 80 hours in any month to  performing
the Employment Services.

                  (b)  Executive  shall  perform  the  Employment   Services  at
locations of his choice  consistent with  performing the Employment  Services to
the best of his abilities in a diligent,


<PAGE>



trustworthy,  businesslike  and  professional  manner,  traveling on business as
Executive and the Company shall reasonably deem necessary.

         3.       Compensation.

                  (a)  During  the  Employment  Period,  the  Company  will  pay
Executive for the  Employment  Services a base salary (the "Base Salary") at the
annual  rate of $  159,000  or such  other  increased  rate as the  compensation
committee of the Board or Board committee  performing  equivalent functions (the
"Compensation  Committee") (or if the Board has no Compensation Committee at the
time, then the Board) may designate from time to time, such salary to be paid at
such periods as salary is paid to other executive  officers of the Company.  The
Compensation  Committee  (or the Board,  if  applicable)  shall  review the Base
Salary of the Executive at least  annually on the  anniversary  of the Effective
Date and may, in its sole  discretion,  increase  (but not  decrease)  such Base
Salary  from time to time.  Payment of the Base  Salary  shall be subject to the
customary withholding tax and other employment taxes as required with respect to
compensation paid by a corporation to an employee.

                  (b) Executive  may receive an annual bonus in such amount,  if
any,  as  the  Compensation  Committee  (or  if the  Board  has no  Compensation
Committee  at the  time,  then  the  Board),  in its  discretion,  may  award to
Executive, based upon Executive's and the Company's performance during each year
of the Employment  Period,  provided,  however that each annual bonus payable to
Executive during the Employment Period shall not be less than the greater of (i)
$20,000 or (ii) the amount of the highest annual bonus paid to Executive for the
three most recent fiscal years of the Company.

                  (c) The  Executive  shall be  entitled  to receive  such stock
options  during the  Employment  Period as  determined  from time to time by the
Compensation  Committee  (or if the Board has no  Compensation  Committee at the
time, then the Board).

         4.  Reimbursement  for Expenses.  The Company shall promptly  reimburse
Executive  for all  reasonable  out-of-pocket  expenses  incurred  by him in the
course of performing his duties under this Agreement (including reimbursement of
$40,000 per year for Executive's expenses in maintaining an office),  subject to
the   Company's   reasonable   requirements   with  respect  to  reporting   and
documentation of such expenses.

         5. Benefits. Executive shall be entitled to all fringe benefits offered
by the Company  and to  participate  in all of the  Company's  employee  benefit
programs both on the same basis as available to  executives of the Company,  and
shall be  entitled  to such  other  benefits  as may  from  time to time be made
available to  Executive.  The Company  shall use  commercially  reasonable  best
efforts to obtain and keep directors' and officers' liability insurance coverage
in effect in an amount equivalent to that of a well-insured,  similarly-situated
company;  provided,  however, that the failure to obtain and keep such insurance
in effect after the Company has  exercised  such  commercially  reasonable  best
efforts shall not be a breach of the Company's obligations under this Agreement.
During the Employment Period,  Executive shall be entitled to four weeks of paid
vacation  prorated,  based on 80 hours  worked per month during each year of the
Employment Period, and may carry over up to four weeks of vacation from one year
to the next succeeding year only.

                                        2

<PAGE>



         6.       Term and Termination.

                  (a)  Except  as  otherwise  provided  in this  Agreement,  the
Employment Period shall terminate upon the earlier of:

     (i) three  years from the  Effective  Date  hereof  (the  "Initial  Term");
provided,  however,  that  commencing  on the date one year after the  Effective
Date,  and on each  annual  anniversary  of such date (such date and each annual
anniversary  thereof shall be  hereinafter  referred to as the "Renewal  Date"),
unless  previously  terminated,  the  Employment  Period shall be  automatically
extended so as to terminate  three years from such Renewal  Date,  unless either
Executive  or the Board  shall have given  written  notice to the other party no
later than 180 days prior to the Renewal Date that the  Employment  Period shall
not be so extended;

     (ii) Executive's  incapacity or permanent  disability (which in either case
shall be deemed to occur only in the event  Executive  is unable to perform  the
Employment Services for 180 days in any 12-month period) or death;

     (iii)  termination by Executive  voluntarily or for Good Reason (as defined
below);

     (iv) termination by the Company with or without Cause (as defined below).

                  (b) If the Employment  Period is terminated (i) by the Company
without  Cause or (ii) by Executive  for Good Reason,  then  Executive  shall be
entitled to receive,  so long as Executive  has not breached the  provisions  of
Paragraphs  9, 10,  12, 13,  14, or 16 hereof in a manner  that could  adversely
affect  the  Company,  his  Base  Salary  in cash at the  periods  set  forth in
Paragraph 3, at a rate equal to the then  applicable rate set forth in Paragraph
3 for a period  equal to the  greater  of (x) the  remainder  of the  Employment
Period,  but not in excess of three  years or (y) two years plus in either  case
(I) the  greater  of (A) the  most  recent  annual  bonus,  if any,  awarded  to
Executive  pursuant to  Paragraph  3(b) during the  Company's  fiscal year of or
during the Company's  fiscal year prior to termination,  as the case may be, (B)
the  average  amount  of the last  three  annual  bonuses,  if any,  awarded  to
Executive  pursuant to  Paragraph  3(b) prior to  termination,  or (C)  $20,000,
multiplied by in any case not less than the number of years for which  Executive
is entitled to receive his Base Salary pursuant to this Paragraph 6(b) (prorated
for any partial  year) (such bonus amounts to be paid pro rata over the term for
which  Executive  is  entitled  to  receive  his Base  Salary  pursuant  to this
Paragraph  6(b));  plus (II) at Executive's  election,  medical,  dental and any
other health  insurance,  life  insurance,  accidental  death and  dismemberment
insurance  and  disability  protection  no less  favorable to Executive  and his
dependents  covered thereby  (including that Executive shall remain obligated to
continue  to pay any  costs or  expenses  which  Executive  would  otherwise  be
obligated  to pay  pursuant  to such  insurance  or other  protections  provided
pursuant to Paragraph 5 as in existence on the date of such  termination)  until
the first to occur of (i) the date of Executive's  re-employment  and subsequent
opportunity  to  participate  in any health  insurance  program with  comparable
coverage provided by such new employer,  including without limitation,  coverage
with respect to any  pre-existing  conditions or (ii) eighteen months after such
termination date.

                                        3

<PAGE>





                  (c) If a Change of  Control  (as  defined  below)  occurs  and
Executive  is  thereafter  offered and  accepts  continued  employment  with the
Company (or its  successor),  and either (i) he is still employed by the Company
on the  first  calendar  anniversary  of the  Change  of  Control,  or (ii)  his
employment  with the Company is  terminated  by the Company  without Cause or he
terminates  his  employment  for Good Reason  during such one year  period,  the
Company shall pay Executive, in addition to any other amounts payable hereunder,
a "stay bonus"  equal to one year's then current Base Salary.  Such "stay bonus"
shall be paid in a cash lump sum to Executive  within twenty (20) days following
the earlier of (i) the first anniversary of the date of the Change of Control or
(ii) the date of his termination of employment with the Company. For purposes of
this  Agreement,  a  "Change  of  Control"  means  the  happening  of any of the
following:  (i) the merger or  consolidation of the Company into a new surviving
company  in  which  the  holders  of  the  Company's  voting  securities  (on  a
fully-diluted  basis)  immediately prior to the merger or consolidation own less
than a majority  of the  ordinary  voting  power to elect  directors  of the new
surviving  company  (on a fully  diluted  basis),  or (ii) when any  "person" as
defined in Section 3(a)(9) of the Securities Exchange Act of 1934 (the "34 Act")
and as used in Sections 13(d) and 14(d) thereof,  including a "group" as defined
in Section 13(d) of the 34 Act but  excluding the Company and any  Subsidiary or
any  employee  benefit  plan  sponsored  or  maintained  by the  Company  or any
Subsidiary  (including  a trustee of such plan acting as  trustee),  directly or
indirectly,  becomes the "beneficial  owner" (as defined in Rule 13d-3 under the
34 Act, as amended from time to time), of securities of the Company representing
25% or more of the  combined  voting  power of the  Company's  then  outstanding
securities.

                  (d)  Except  as  provided  in  Paragraphs  6(b) or  (c),  upon
termination of the  Employment  Period,  Executive  shall be entitled to receive
only  (i)  accrued  but  unpaid  salary  and  bonus  through  the  date  of such
termination and (ii) unpaid salary with respect to any vacation days accrued but
not taken as of the date of such termination.

                  (e) For purposes of this Agreement, "Cause" shall mean (i) the
conviction (or plea of nolo  contendere) of a felony or a crime  involving moral
turpitude or the  commission of any other act which has an adverse effect on the
Company and which involves  dishonesty,  disloyalty or fraud with respect to the
Company or any of its Subsidiaries,  (ii) conduct bringing the Company or any of
its  Subsidiaries  into  substantial  public  disgrace or disrepute,  including,
without limitation, such conduct resulting from repeated acts of alcohol or drug
abuse, (iii) continued failure by Executive to substantially  perform his duties
as reasonably  directed by the Board for a period of 15 days after the Board has
made a demand for  substantial  performance  which  specifically  identifies the
manner  in  which  the  Board  believes  that  Executive  has not  substantially
performed his duties,  or (iv) gross  negligence or misconduct not in good faith
with  respect  to the  Company  or any of its  Subsidiaries,  or (v)  any  other
material  breach  of this  Agreement  which is not cured  within  15 days  after
Executive's receipt of written notice thereof.

                  (f)  For  purposes  of  this  Agreement,  termination  of  the
Employment  Period by Executive  for "Good  Reason"  shall mean  termination  by
Executive  (i) within 90 days after  Executive  has been  assigned,  without his
consent,  to any duties  substantially  inconsistent with his position,  duties,
responsibilities  or status with the Company as  contemplated  in Paragraph 1 of
this

                                        4

<PAGE>



Agreement;  (ii) upon 120 days'  prior  written  notice if such  notice is given
within 30 days after the date  Executive  ceases,  without his consent,  to be a
member of the Board;  (iii)  following a Change of Control,  upon failure of the
Company to pay  Executive  an annual  bonus equal to the average  amount of such
annual  bonus paid to  Executive  during the three  fiscal  years of the Company
immediately  preceding  the year in which the  Change of  Control  occurs;  (iv)
following a reduction of Executive's  Base Salary after a Change of Control;  or
(v) upon a material  breach of this  Agreement by the Company which is not cured
within 30 days after the Company's receipt of written notice thereof.  Executive
shall  provide  written  notice  to the  Company  of any  and all  grounds  that
Executive  alleges  constitute  "Good Reason" and the Company shall have 30 days
after receipt of such written notice to cure any such alleged  grounds for "Good
Reason".  If,  following the expiration of such 30 day period,  Executive  still
believes  that "Good  Reason"  exists for his  termination  of  Employment,  the
provisions of Paragraph 7 shall apply.

                  (g) Promptly  (but in any event within 20 days)  following any
termination  of the  Employment  Period,  and as of that date,  the Company will
notify  Executive of the itemized and  aggregate  cash value of the payments and
benefits,  as determined  under  Section 280G of the Internal  Revenue Code (the
"Code"),  received  or to be  received  by  Executive  in  connection  with  the
termination of his  employment  (whether  payable  pursuant to the terms of this
Agreement or otherwise). At the same time, the Company shall advise Executive of
the portion of such payments or benefits  which  constitute  parachute  payments
within the meaning of the Code and which may subject Executive to the payment of
excise  taxes  pursuant to Section  4999 and the  expected  amount of such taxes
(such  payments  or  benefits  being  hereinafter   referred  to  as  "Parachute
Payments").

                  (h)  Notwithstanding  the provisions of Paragraph 6(b) hereof,
if all or any portion of the payments or benefits  provided under Paragraph 6(b)
either alone or together  with other  payments or benefits  which  Executive has
received  or is  then  entitled  to  receive  from  the  Company  and any of its
Subsidiaries  would  constitute  Parachute  Payments,  such payments or benefits
provided  to  Executive  under  Paragraph  6(b)  shall be  reduced to the extent
necessary so that no portion  thereof shall be subject to the excise tax imposed
by  Section  4999 of the  Code;  but  only  if,  by  reason  of such  reduction,
Executive's net after tax benefit shall exceed the net after tax benefit if such
reduction were not made.  "Net after tax benefit" for purposes of this Paragraph
6(h)  shall mean the sum of (i) the total  amount  payable  to  Executive  under
Paragraphs 6(b) and (c) hereof,  plus (ii) all other payments and benefits which
Executive  has received or is then  entitled to receive from the Company and any
of its subsidiaries  that would constitute a Parachute  Payment,  less (iii) the
amount of federal  income taxes payable with respect to the payment and benefits
described in (i) and (ii) above  calculated at the maximum  marginal  income tax
rate  for  each  year in  which  such  payments  and  benefits  shall be paid to
Executive  (based upon the rate in effect for such year as set forth in the Code
at the  Termination  Date),  less (iv) the amount of excise  taxes  imposed with
respect to the payments and benefits  described in (i) and (ii) above by Section
4999 of the Code.

                  For purposes of this Paragraph 6(h),  Executive's base amount,
the present  value of the Parachute  Payments,  the amount of the excise tax and
all other appropriate  matters shall be determined by the Company's  independent
auditors in accordance with the principles of Section 280G of the Code and based
upon the advice of tax counsel selected by the Company,  which tax counsel shall
be reasonably satisfactory to Executive.


                                        5

<PAGE>



         7.  Notice of Certain  Terminations.  In the event that  either (i) the
Company shall  terminate  Executive for Cause or (ii) Executive  shall terminate
for Good Reason,  then any such  termination  shall be  communicated  by written
notice to the other party hereto. Any such notice shall specify(x) the effective
date of  termination  of the  Employment  Period,  which,  except  as  otherwise
provided in  Paragraph  6(f),  shall not be more than 30 days after the date the
notice is delivered  (the  "Termination  Effective  Date"` and (y) in reasonable
detail  the  facts  and  circumstances   underlying  a  determination  that  the
termination  is for Cause or for Good  Reason,  as the case may be. If within 15
days after any notice of  termination  of Executive  for Cause by the Company is
given,  or if  within 15 days  after  the  Company's  30 day cure  period  under
Paragraph 6(f) has expired,  the party  receiving such notice notifies the other
party that a good faith dispute exists  concerning the  characterization  of the
termination,  the  Termination  Effective  Date  shall be the date on which such
dispute is finally  resolved  either by written  agreement  of the parties or by
binding arbitration  conducted pursuant to the rules of the American Arbitration
Association. Notwithstanding the pendency of any such dispute, the Company shall
continue Executive and his dependents as participants in all medical, dental and
any other health  insurance and similar benefit plans of the Company in which he
and they were  participating  when the notice  giving  rise to the  dispute  was
given,  until the  dispute is finally  resolved.  Benefits  provided  under this
Paragraph 7 are in addition to all other  amounts due under this  Agreement  and
shall not be  offset  against,  or reduce  any other  amounts  due  under,  this
Agreement.

         8.  Insurance.  The Company  may, at its  election and for its benefit,
insure Executive  against  accidental  death, and Executive shall submit to such
physical  examination  and  supply  such  information  as  may  be  required  in
connection therewith.

         9.       Non-disclosure of Confidential Information.

                  (a) Unless  Executive  first secures  written consent from the
Company  pursuant to  procedures  implemented  by Company after the date hereof,
Executive  shall not disclose or use at any time,  either during the  Employment
Period or thereafter,  any Confidential Information (as defined in Paragraph 17)
except to the extent Executive  reasonably  believes is necessary to disclose or
use  such  Confidential  Information  in  performing  the  Employment  Services.
Executive  further agrees that Executive will use  Executive's  commercial  best
efforts  to  safeguard  the  Confidential  Information  and  protect  it against
disclosure,  misuse, espionage,  loss and theft, including,  without limitation,
causing  recipients of  Confidential  Information  to enter into  non-disclosure
agreements with the Company.  Subject to the provisions of Paragraphs 10 and 13,
nothing herein shall be construed to prevent  Executive  from using  Executive's
general  knowledge  and  skill  after  termination  of this  Agreement,  whether
Executive  acquired  such  knowledge  or skill  before or during the  Employment
Period.

                  (b) In the event the Company has entered into  confidentiality
agreements with third parties (not including  Company  employees)  which contain
provisions  different from those set forth in this Agreement,  Executive agrees,
in  addition  to the  provisions  of  Paragraph  9(a),  to comply  with any such
different provisions of which Executive is notified by the Company.

         10.  Company  Ownership  of  Intellectual  Property.  Executive  hereby
assigns to the Company all right,  title and interest in and to all Intellectual
Property (as defined in  Paragraph  17)  contributed  to or conceived or made by
Executive during the Employment Period and prior to the

                                        6

<PAGE>



Employment  Period  during the period  Executive  was  employed by or engaged in
research or development  activities for or with the Company or its  predecessors
and  affiliates  (whether  alone or jointly  with  others)  to the  extent  such
Intellectual  Property is not owned by the Company as a matter of law. Executive
shall promptly and fully  communicate to the Company all  Intellectual  Property
conceived,  contributed  to or made by Executive  and shall  cooperate  with the
Company  to  protect  the  Company's  interests  in such  Intellectual  Property
including,   without  limitation,   providing   assistance  in  securing  patent
protection  and copyright  registrations  and signing all  documents  reasonably
requested by the  Company,  even if such  request  occurs  after the  Employment
Period.  The Company shall pay  Executive's  reasonable  expenses of cooperating
with the Company in  protecting  the  Company's  interests in such  Intellectual
Property  unless the subject  matter of the requested  cooperation is related to
actions taken or failed to be taken by Executive  wrongfully or otherwise not in
good faith.

         11. Executive's  Rights.  Paragraph 10 of this Agreement does not apply
to an invention  for which no  equipment,  supplies,  facilities or trade secret
information  of the  Company  was used  and  which  was  developed  entirely  on
Executive's  own time,  unless (a) the invention  relates (i) to the business of
the  Company,  or (ii)  to the  Company's  actual  or  demonstrably  anticipated
material  research or  development,  or (b) the invention  results from any work
performed by Executive for the Company.

         12. Return of Materials.  Upon termination of the Employment Period, or
at any time  reasonably  requested  by the  Company,  Executive  shall  promptly
deliver to the Company all copies of  Confidential  Information  in  Executive's
possession  and control,  including  written  records,  manuals,  lab notebooks,
customer and supplier lists and all other materials  containing any Confidential
Information.   If  the  Company   requests,   Executive  shall  provide  written
confirmation  that  Executive  has returned all such  materials.  Subject to the
provisions  of this  Agreement,  including,  without  limitation,  Paragraph 11,
notwithstanding  anything in this Agreement to the contrary, upon termination of
the  Employment  Period,  the Company,  at Executive's  request,  shall promptly
return to Executive any  equipment or other  materials  owned by Executive  then
being used by or then in the possession of the Company.

         13. Non-Competition.  Executive acknowledges and agrees that during the
Employment  Period and for a period of five years  thereafter (the  "Non-compete
Period"),  Executive will not, without the prior written consent of the Company,
directly or indirectly,  provide products or services  substantially  similar to
the  Employment  Services to any  business or entity that  provides or offers or
demonstrably  plans to provide or offer,  products or services  that (i) are the
same as or  substantially  similar to the  products or services  provided by the
Company at any time during the Employment  Period,  (ii) relate to the Company's
Intellectual  Property (whether the Company acquired such Intellectual  Property
pursuant to this Agreement or otherwise),  or (iii) relate to any subject matter
of the  Company's  actual or  demonstrably  anticipated  material  research  and
development during the Employment Period,  including without limitation,  taxol,
taxanes  and any other  compounds,  within  any  geographical  area in which the
Company or any of its  subsidiaries  provide or plan to provide such products or
services.

         14. Non-Solicitation. Executive acknowledges and agrees that during the
Non-compete Period Executive will not (a) solicit,  induce or attempt to induce,
directly or indirectly, any employee

                                        7

<PAGE>



of the Company to leave the  employment  of the Company to work for Executive or
for any  other  person,  firm or  corporation  or (b) hire any  employee  of the
Company.

         15. Acknowledgment of Reasonableness. Executive acknowledges and agrees
that the  limitations  set forth in  Paragraphs  13 and 14 are  reasonable  with
respect to scope, duration and geographic area and are properly required for the
protection of the legitimate business interest of the Company.

         16. Further Assistance.  During the Non-compete Period,  Executive will
not make any disclosure or other  communication to any person,  issue any public
statements or otherwise cause to be disclosed any information which is designed,
intended or might reasonably be anticipated to discourage any persons from doing
business with the Company or otherwise have a negative  impact or adverse effect
on the Company,  except to the extent such disclosure is required by law. During
the Non-compete Period,  Executive will provide assistance  reasonably requested
by the  Company  in  connection  with  actions  taken by  Executive  during  the
Employment  Period,  including but not limited to assistance in connection  with
any lawsuits or other claims against the Company  arising from events during the
Employment  Period,  provided  that the Company shall  reimburse all  reasonable
expenses  (including  without  limitation,  reasonable loss of compensation from
other sources resulting from such assistance during normal business hours).

         17.      Certain Definitions.

                  "Affiliate"  means  a  person  that  directly,  or  indirectly
through one or more intermediaries,  controls,  or is controlled by, or is under
common control with, the person specified.

                  "Confidential  Information" means all information  (whether or
not specifically labeled or identified as confidential),  in any form or medium,
that is disclosed to, or developed or learned by Executive during the Employment
Period  and prior to the  Employment  Period  during the  period  Executive  was
employed  by or engaged in research or  development  activities  for or with the
Company or its  predecessors  and  affiliates  or that relates to the  business,
products,  services,  customers,  research or  development  of the Company,  its
Subsidiaries,  its  Affiliates,  or third  parties  with whom the  Company,  its
Subsidiaries  or its  Affiliates  does  business or from whom the Company or its
Affiliates receives information.  Confidential Information shall not include any
information that (i) has become publicly known through no wrongful act or breach
of any  obligation  of  confidentiality,  as  evidenced  by  written  records or
documents;  or (ii) was rightfully  received by Executive on a  non-confidential
basis  from a third  party  (provided  that  such  third  party is not  known to
Executive to be bound by a confidentiality agreement with the Company or another
party), as evidenced by written records or documents.

                  "Independent  Third  Party"  means  any  person,  including  a
"group" as defined in Section  13(d)(3) of the Securities  Exchange Act of 1934,
as amended, and the rules and regulations thereunder,  who, immediately prior to
the  contemplated  transaction,  does not own in excess  of 5% of the  Company's
Common Stock on a fully-diluted basis, who is not controlling,  controlled by or
under common  control with any such 5% owner of the  Company's  Common Stock and
who is not the spouse or descendent  (by birth or adoption) of any such 5% owner
of the Company's Common Stock.

                                        8

<PAGE>




                  "Intellectual  Property"  means any idea,  invention,  design,
development,  device, method or process (whether or not patentable or reduced to
practice or  including  Confidential  Information)  and all related  patents and
patent  applications,  any  copyrightable  work or  mask  work  (whether  or not
including   Confidential   Information)  and  all  related   registrations   and
applications for registration, and all other proprietary rights.

                  "Subsidiaries"  means any  corporation of which the securities
having a majority of the voting power in electing  directors are, at the time of
determination,   owned  by  the  Company,   directly  or  through  one  of  more
Subsidiaries.

         18. Executive Representations. Executive hereby represents and warrants
to the  Company  that  (a)  the  execution,  delivery  and  performance  of this
Agreement by Executive does not and will not conflict with,  breach,  violate or
cause a default under any contract,  agreement,  instrument,  order, judgment or
decree to which  Executive is a party or by which he is bound,  and (b) upon the
execution and delivery of this Agreement by the Company, this Agreement shall be
the valid and binding  obligation of Executive,  enforceable in accordance  with
its terms.

         19. Company Representations. The Company hereby represents and warrants
to Executive that (a) the execution,  delivery and performance of this Agreement
by the Company does not and will not conflict with,  breach,  violate or cause a
default under any contract, agreement,  instrument, order, judgment or decree to
which Company is a party or by which it is bound, and (b) upon the execution and
delivery of this Agreement by Executive,  this Agreement  shall be the valid and
binding obligation of the Company, enforceable in accordance with its terms.

         20.  Severability and Modification.  If any provision of this Agreement
shall be held or declared to be illegal, invalid or unenforceable, such illegal,
invalid or unenforceable  provision shall not affect any other provision of this
Agreement,  and the remainder of this Agreement shall continue in full force and
effect as though such provision had not been contained in this Agreement. If the
scope of any  provision  in this  Agreement  is found to be too  broad to permit
enforcement of such provision to its full extent, Executive consents to judicial
modification of such provision and  enforcement to the maximum extent  permitted
by law.

         21. Notices. Except as otherwise expressly set forth in this Agreement,
all notices, requests and other communications to be given or delivered under or
by reason of the provisions of this  Agreement  shall be in writing and shall be
given (and, except as otherwise  provided in this Agreement,  shall be deemed to
have  been  duly  given if so  given)  when  delivered  if given in person or by
telegram,  three days after being mailed by first class  registered or certified
mail,  return receipt  requested,  postage prepaid,  or one day after being sent
prepaid  via  reputable  overnight  courier  to the  parties  at  the  following
addresses  (or such  other  address  as shall be  furnished  in  writing by like
notice;  provided,  however, that notice of change of address shall be effective
only upon receipt):


                                        9

<PAGE>



Notices to Executive
         Leonard P. Shaykin
         c/o NaPro BioTherapeutics, Inc.
         6304 Spine Road, Unit A
         Boulder, Colorado  80301

Notices to Company
         NaPro BioTherapeutics,
         6304 Spine Road, Unit A
         Boulder, Colorado 80301

         Attn.:   Patricia A. Pilia, Ph.D.
                  Executive Vice President

         with a copy to:
         Holme Roberts & Owen
         1700 Lincoln, Suite 4100
         Denver, CO 80203

         Attn.:  Francis Wheeler

     22. Entire Agreement.  This Agreement contains the entire agreement between
the  parties  with  respect to the  subject  matter  hereof and  supersedes  any
previous  understandings or agreements,  whether written or oral, regarding such
subject matter, including but not limited to the Prior Agreement.

     23. Governing Law. All questions concerning the construction,  validity and
interpretations  of this Agreement will be governed by the internal law, and not
the law of conflicts, of the State of Colorado.

         24. Survival.  Paragraphs 6, 9, 10, 11, 12, 13, 14 and 16 and any other
provision of this Agreement which by its terms could survive  termination of the
Employment  Period shall survive and continue in full force in  accordance  with
their terms notwithstanding any termination of the Employment Period.

     25. Counterparts.  This Agreement may be executed in separate counterparts,
each of which is  deemed  to be an  original  and all of  which  taken  together
constitute one and the same agreement.

     26. Successors and Assigns. This Agreement is intended to bind and inure to
the benefit of and be enforceable by Executive, the Company and their respective
successors and assigns;  provided that in no event shall Executive's obligations
under this  Agreement  be  delegated  or  transferred  by  Executive,  nor shall
Executive's  rights be subject to  encumbrance  or to the claims of  Executive's
creditors.  This  Agreement  is for the sole  benefit of the parties  hereto and
shall not create any rights in third  parties other than  Executive's  spouse or
beneficiary as expressly set forth herein.


                                       10

<PAGE>



     27. Remedies.  Except as otherwise provided in this Agreement,  (i) each of
the parties to this  Agreement will be entitled to enforce its rights under this
Agreement  specifically,  to  recover  damages  by reason  of any  breach of any
provision of this  Agreement and to exercise all other rights to which it may be
entitled and (ii) disputes under this Agreement not finally  resolved in writing
by the parties  within  sixty days after one party gives notice in good faith to
the other party that a bona fide dispute  exists  shall be resolved  pursuant to
binding arbitration  conducted in Denver,  Colorado in accordance with the rules
of the  American  Arbitration  Association.  The  prevailing  party  in any such
arbitration  shall  be  entitled  to have  its  costs  and  expenses  (including
reasonable  attorney's fees and expenses)  relating to such  arbitration paid by
the other party if the  arbitrator(s)  conducting such arbitration so determine.
Notwithstanding  the  foregoing,  the parties agree and  acknowledge  that money
damages  may not be an  adequate  remedy  for breach of the  provisions  of this
Agreement  and that any party may in its sole  discretion  apply to any court of
law  or  equity  of  competent  jurisdiction  for  specific  performance  and/or
injunctive  relief  in  order  to  enforce  or  prevent  any  violations  of the
provisions of this Agreement. The prevailing party in any suit shall be entitled
to recover reasonable attorneys fees and costs from the other party.

     28.  Modifications  and  Waivers.  No provision  of this  Agreement  may be
modified,  altered or amended except by an instrument in writing executed by the
parties  hereto.  No waiver by either  party  hereto of any  breach by the other
party hereto of any term or provision of this  Agreement to be performed by such
other  party  shall  be  deemed a  waiver  of  similar  or  dissimilar  terms or
provisions at the time or at any prior or subsequent time.

     29. Headings.  The headings  contained herein are solely for the purpose of
reference,  are not part of this  Agreement  and shall not in any way affect the
meaning or interpretation of this Agreement.

     30. Notification of Subsequent Employer.  Executive agrees that the Company
may present a copy of this Agreement to any third party.

     31.  UNDERSTAND  AGREEMENT.  EXECUTIVE  REPRESENTS  AND  WARRANTS  THAT (a)
EXECUTIVE HAS READ AND UNDERSTOOD  EACH AND EVERY  PROVISION OF THIS  AGREEMENT,
(b)  EXECUTIVE  HAS HAD THE  OPPORTUNITY  TO OBTAIN ADVICE FROM LEGAL COUNSEL OF
EXECUTIVE'S  CHOICE,  OTHER THAN COUNSEL TO THE COMPANY (WHO IS NOT REPRESENTING
THE EXECUTIVE),  IN ORDER TO INTERPRET ANY AND ALL PROVISIONS OF THIS AGREEMENT,
(c) EXECUTIVE HAS HAD THE  OPPORTUNITY TO ASK THE COMPANY  QUESTIONS  ABOUT THIS
AGREEMENT  AND ANY OF SUCH  QUESTIONS  EXECUTIVE HAS ASKED HAVE BEEN ANSWERED TO
EXECUTIVE'S  SATISFACTION,  AND  (d)  EXECUTIVE  HAS  BEEN  GIVEN A COPY OF THIS
AGREEMENT.


                                       11

<PAGE>


         IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
duly executed on the day and year first above written.

                                  EXECUTIVE

                                           /s/ Leonard P. Shaykin
                                  -----------------------------------
                                           Leonard P. Shaykin


                                  NAPRO BIOTHERAPEUTICS, INC.


                                  By:______/s/ Gordon H. Link, Jr.______________
                                           Gordon H. Link, Jr.
                                           Vice President, Finance and
                                           Chief Financial Officer


                                       12

<PAGE>





                          AMENDED EMPLOYMENT AGREEMENT

         THIS AGREEMENT (the "Agreement") is entered into effective this 5th day
of October,  1998 (the "Effective Date"), by and between NaPro  BioTherapeutics,
Inc.,  a  Delaware  corporation  (the  "Company"),  and  Sterling  K.  Ainsworth
("Executive"). Certain capitalized terms used in this Agreement have the meaning
set forth in Paragraph 17 hereof.

                                    RECITALS

         A. WHEREAS,  the Company and the Executive have previously entered into
an Amended and Restated  Employment and Executive Stock  Agreement,  dated as of
June 7, 1993 and amended and restated  effective as of May 31, 1994, (the "Prior
Agreement"); and

         B. WHEREAS,  the Company  desires to secure the  continued  services of
Executive as an employee of the Company, and to provide for certain compensation
and benefit  arrangements for Executive in the event of Executive's  termination
of  employment  under certain  circumstances,  and Executive is willing to enter
into this Agreement and perform such services.

                              TERMS AND CONDITIONS

         In  consideration  of the  respective  covenants and  agreements of the
parties  contained in this Agreement,  the parties agree to amend and restate in
its entirety the Prior Agreement as follows:

         1. Employment Services.  The Company hereby agrees to engage Executive,
and Executive  hereby agrees to perform  services for the Company,  on the terms
and conditions  set forth in this  Agreement.  During the Employment  Period (as
defined below),  the Company and Executive agree that Executive will serve as an
executive  officer  of the  Company  in the  position  of  President  and  Chief
Executive Officer with the duties,  responsibilities  and authority as set forth
on Schedule A, or will have such other  executive title and such other executive
duties,  responsibilities  and  authority as Executive and the Company may agree
upon from time to time,  and will  perform  such  services of an  executive  and
administrative  character to the Company and its present or future  Subsidiaries
consistent  with the duties of the Company's other  executive  officers,  as the
Company's  Board of  Directors  (the  "Board") may from time to time direct (the
"Employment  Services") or the Bylaws of the Company may provide. The Employment
Services  shall commence upon the Effective Date of this Agreement and terminate
as provided in Paragraph 6 (the "Employment Period").

         2.       Performance.

                  (a) Executive  shall report to the Board,  and Executive shall
devote his best  efforts to the  business  and  affairs of the  Company  and its
Subsidiaries;  provided,  however,  that upon prior agreement by the Board,  and
subject to the terms of this  Agreement,  Executive  may  engage in  independent
activities in areas unrelated to the Company's  business or the Company's actual
or  demonstrably  anticipated  business;  and  provided,  further,  that no such
independent  activities shall materially  detract from the essentially full time
commitment  of Executive  to the business and affairs of the Company.  Executive
shall perform his duties and  responsibilities to the best of his abilities in a
diligent, trustworthy, businesslike and professional manner.



<PAGE>



                  (b)  Unless  the  Company  and  Executive   otherwise   agree,
Executive  shall  perform the  Employment  Services at the  Company's  executive
offices and traveling on business as Executive and the Company shall  reasonably
deem necessary.

         3.       Compensation.

                  (a)  During  the  Employment  Period,  the  Company  will  pay
Executive for the  Employment  Services a base salary (the "Base Salary") at the
annual  rate  of  $175,000  or such  other  increased  rate as the  compensation
committee of the Board or Board committee  performing  equivalent functions (the
"Compensation  Committee") (or if the Board has no Compensation Committee at the
time, then the Board) may designate from time to time, such salary to be paid at
such periods as salary is paid to other executive  officers of the Company.  The
Compensation  Committee  (or the Board,  if  applicable)  shall  review the Base
Salary of the Executive at least  annually on the  anniversary  of the Effective
Date and may, in its sole  discretion,  increase  (but not  decrease)  such Base
Salary  from time to time.  Payment of the Base  Salary  shall be subject to the
customary withholding tax and other employment taxes as required with respect to
compensation paid by a corporation to an employee.

                  (b) Executive  may receive an annual bonus in such amount,  if
any,  as  the  Compensation  Committee  (or  if the  Board  has no  Compensation
Committee  at the  time,  then  the  Board),  in its  discretion,  may  award to
Executive, based upon Executive's and the Company's performance during each year
of the Employment  Period,  provided,  however that each annual bonus payable to
Executive during the Employment Period shall not be less than the greater of (i)
$20,000 or (ii) the amount of the highest annual bonus paid to Executive for the
three most recent fiscal years of the Company.

                  (c) The  Executive  shall be  entitled  to receive  such stock
options  during the  Employment  Period as  determined  from time to time by the
Compensation  Committee  (or if the Board has no  Compensation  Committee at the
time, then the Board).

         4.  Reimbursement  for Expenses.  The Company shall promptly  reimburse
Executive  for all  reasonable  out-of-pocket  expenses  incurred  by him in the
course of performing his duties under this  Agreement,  subject to the Company's
reasonable  requirements  with respect to reporting  and  documentation  of such
expenses.

         5. Benefits. Executive shall be entitled to all fringe benefits offered
by the Company  and to  participate  in all of the  Company's  employee  benefit
programs both on the same basis as available to  executives of the Company,  and
shall be  entitled  to such  other  benefits  as may  from  time to time be made
available to  Executive.  The Company  shall use  commercially  reasonable  best
efforts to obtain and keep directors' and officers' liability insurance coverage
in effect in an amount equivalent to that of a well-insured,  similarly-situated
company;  provided,  however, that the failure to obtain and keep such insurance
in effect after the Company has  exercised  such  commercially  reasonable  best
efforts shall not be a breach of the Company's obligations under this Agreement.
During the Employment Period,  Executive shall be entitled to four weeks of paid
vacation during each year of the Employment Period and may carry over up to four
weeks of vacation from one year to the next succeeding year only.

                                        2

<PAGE>



         6.       Term and Termination.

                  (a)  Except  as  otherwise  provided  in this  Agreement,  the
Employment Period shall terminate upon the earlier of:

     (i) three  years from the  Effective  Date  hereof  (the  "Initial  Term");
provided,  however,  that  commencing  on the date one year after the  Effective
Date,  and on each  annual  anniversary  of such date (such date and each annual
anniversary  thereof shall be  hereinafter  referred to as the "Renewal  Date"),
unless  previously  terminated,  the  Employment  Period shall be  automatically
extended so as to terminate  three years from such Renewal  Date,  unless either
Executive  or the Board  shall have given  written  notice to the other party no
later than 180 days prior to the Renewal Date that the  Employment  Period shall
not be so extended;

     (ii) Executive's  incapacity or permanent  disability (which in either case
shall be deemed to occur only in the event  Executive  is unable to perform  the
Employment Services for 180 days in any 12-month period) or death;

     (iii)  termination by Executive  voluntarily or for Good Reason (as defined
below);

     (iv) termination by the Company with or without Cause (as defined below).

                  (b) If the Employment  Period is terminated (i) by the Company
without  Cause or (ii) by Executive  for Good Reason,  then  Executive  shall be
entitled to receive,  so long as Executive  has not breached the  provisions  of
Paragraphs  9, 10,  12, 13,  14, or 16 hereof in a manner  that could  adversely
affect  the  Company,  his  Base  Salary  in cash at the  periods  set  forth in
Paragraph 3, at a rate equal to the then  applicable rate set forth in Paragraph
3 for a period  equal to the  greater  of (x) the  remainder  of the  Employment
Period,  but not in excess of three  years or (y) two years plus in either  case
(I) the  greater  of (A) the  most  recent  annual  bonus,  if any,  awarded  to
Executive  pursuant to  Paragraph  3(b) during the  Company's  fiscal year of or
during the Company's  fiscal year prior to termination,  as the case may be, (B)
the  average  amount  of the last  three  annual  bonuses,  if any,  awarded  to
Executive  pursuant to  Paragraph  3(b) prior to  termination,  or (C)  $20,000,
multiplied by in any case not less than the number of years for which  Executive
is entitled to receive his Base Salary pursuant to this Paragraph 6(b) (prorated
for any partial  year) (such bonus amounts to be paid pro rata over the term for
which  Executive  is  entitled  to  receive  his Base  Salary  pursuant  to this
Paragraph  6(b));  plus (II) at Executive's  election,  medical,  dental and any
other health  insurance,  life  insurance,  accidental  death and  dismemberment
insurance  and  disability  protection  no less  favorable to Executive  and his
dependents  covered thereby  (including that Executive shall remain obligated to
continue  to pay any  costs or  expenses  which  Executive  would  otherwise  be
obligated  to pay  pursuant  to such  insurance  or other  protections  provided
pursuant to Paragraph 5 as in existence on the date of such  termination)  until
the first to occur of (i) the date of Executive's  re-employment  and subsequent
opportunity  to  participate  in any health  insurance  program with  comparable
coverage provided by such new employer,  including without limitation,  coverage
with respect to any  pre-existing  conditions or (ii) eighteen months after such
termination date.

                                        3

<PAGE>




                  (c) If a Change of  Control  (as  defined  below)  occurs  and
Executive  is  thereafter  offered and  accepts  continued  employment  with the
Company (or its  successor),  and either (i) he is still employed by the Company
on the  first  calendar  anniversary  of the  Change  of  Control,  or (ii)  his
employment  with the Company is  terminated  by the Company  without Cause or he
terminates  his  employment  for Good Reason  during such one year  period,  the
Company shall pay Executive, in addition to any other amounts payable hereunder,
a "stay bonus"  equal to one year's then current Base Salary.  Such "stay bonus"
shall be paid in a cash lump sum to Executive  within twenty (20) days following
the earlier of (i) the first anniversary of the date of the Change of Control or
(ii) the date of his termination of employment with the Company. For purposes of
this  Agreement,  a  "Change  of  Control"  means  the  happening  of any of the
following:  (i) the merger or  consolidation of the Company into a new surviving
company  in  which  the  holders  of  the  Company's  voting  securities  (on  a
fully-diluted  basis)  immediately prior to the merger or consolidation own less
than a majority  of the  ordinary  voting  power to elect  directors  of the new
surviving  company  (on a fully  diluted  basis),  or (ii) when any  "person" as
defined in Section 3(a)(9) of the Securities Exchange Act of 1934 (the "34 Act")
and as used in Sections 13(d) and 14(d) thereof,  including a "group" as defined
in Section 13(d) of the 34 Act but  excluding the Company and any  Subsidiary or
any  employee  benefit  plan  sponsored  or  maintained  by the  Company  or any
Subsidiary  (including  a trustee of such plan acting as  trustee),  directly or
indirectly,  becomes the "beneficial  owner" (as defined in Rule 13d-3 under the
34 Act, as amended from time to time), of securities of the Company representing
25% or more of the  combined  voting  power of the  Company's  then  outstanding
securities.

                  (d)  Except  as  provided  in  Paragraphs  6(b) or  (c),  upon
termination of the  Employment  Period,  Executive  shall be entitled to receive
only  (i)  accrued  but  unpaid  salary  and  bonus  through  the  date  of such
termination and (ii) unpaid salary with respect to any vacation days accrued but
not taken as of the date of such termination.

                  (e) For purposes of this Agreement, "Cause" shall mean (i) the
conviction (or plea of nolo  contendere) of a felony or a crime  involving moral
turpitude or the  commission of any other act which has an adverse effect on the
Company and which involves  dishonesty,  disloyalty or fraud with respect to the
Company or any of its Subsidiaries,  (ii) conduct bringing the Company or any of
its  Subsidiaries  into  substantial  public  disgrace or disrepute,  including,
without limitation, such conduct resulting from repeated acts of alcohol or drug
abuse, (iii) continued failure by Executive to substantially  perform his duties
as reasonably  directed by the Board for a period of 15 days after the Board has
made a demand for  substantial  performance  which  specifically  identifies the
manner  in  which  the  Board  believes  that  Executive  has not  substantially
performed his duties,  or (iv) gross  negligence or misconduct not in good faith
with  respect  to the  Company  or any of its  Subsidiaries,  or (v)  any  other
material  breach  of this  Agreement  which is not cured  within  15 days  after
Executive's receipt of written notice thereof.

                  (f)  For  purposes  of  this  Agreement,  termination  of  the
Employment  Period by Executive  for "Good  Reason"  shall mean  termination  by
Executive  (i) within 90 days after  Executive  has been  assigned,  without his
consent,  to any duties  substantially  inconsistent with his position,  duties,
responsibilities  or status with the Company as  contemplated  in Paragraph 1 of
this

                                        4

<PAGE>



Agreement;  (ii) upon 120 days'  prior  written  notice if such  notice is given
within 30 days after the date  Executive  ceases,  without his consent,  to be a
member of the Board;  (iii)  following a Change of Control,  upon failure of the
Company to pay  Executive  an annual  bonus equal to the average  amount of such
annual  bonus paid to  Executive  during the three  fiscal  years of the Company
immediately  preceding  the year in which the  Change of  Control  occurs;  (iv)
following a reduction of Executive's Base Salary after a Change of Control;  (v)
if Executive is required to regularly  perform the duties of his employment more
than 50 miles from  Boulder,  Colorado;  or (vi) upon a material  breach of this
Agreement by the Company  which is not cured within 30 days after the  Company's
receipt of written notice thereof. Executive shall provide written notice to the
Company of any and all grounds that Executive  alleges  constitute "Good Reason"
and the Company shall have 30 days after receipt of such written  notice to cure
any such alleged grounds for "Good Reason". If, following the expiration of such
30 day  period,  Executive  still  believes  that "Good  Reason"  exists for his
termination of Employment, the provisions of Paragraph 7 shall apply.

                  (g) Promptly  (but in any event within 20 days)  following any
termination  of the  Employment  Period,  and as of that date,  the Company will
notify  Executive of the itemized and  aggregate  cash value of the payments and
benefits,  as determined  under  Section 280G of the Internal  Revenue Code (the
"Code"),  received  or to be  received  by  Executive  in  connection  with  the
termination of his  employment  (whether  payable  pursuant to the terms of this
Agreement or otherwise). At the same time, the Company shall advise Executive of
the portion of such payments or benefits  which  constitute  parachute  payments
within the meaning of the Code and which may subject Executive to the payment of
excise  taxes  pursuant to Section  4999 and the  expected  amount of such taxes
(such  payments  or  benefits  being  hereinafter   referred  to  as  "Parachute
Payments").

                  (h)  Notwithstanding  the provisions of Paragraph 6(b) hereof,
if all or any portion of the payments or benefits  provided under Paragraph 6(b)
either alone or together  with other  payments or benefits  which  Executive has
received  or is  then  entitled  to  receive  from  the  Company  and any of its
Subsidiaries  would  constitute  Parachute  Payments,  such payments or benefits
provided  to  Executive  under  Paragraph  6(b)  shall be  reduced to the extent
necessary so that no portion  thereof shall be subject to the excise tax imposed
by  Section  4999 of the  Code;  but  only  if,  by  reason  of such  reduction,
Executive's net after tax benefit shall exceed the net after tax benefit if such
reduction were not made.  "Net after tax benefit" for purposes of this Paragraph
6(h)  shall mean the sum of (i) the total  amount  payable  to  Executive  under
Paragraphs 6(b) and (c) hereof,  plus (ii) all other payments and benefits which
Executive  has received or is then  entitled to receive from the Company and any
of its subsidiaries  that would constitute a Parachute  Payment,  less (iii) the
amount of federal  income taxes payable with respect to the payment and benefits
described in (i) and (ii) above  calculated at the maximum  marginal  income tax
rate  for  each  year in  which  such  payments  and  benefits  shall be paid to
Executive  (based upon the rate in effect for such year as set forth in the Code
at the  Termination  Date),  less (iv) the amount of excise  taxes  imposed with
respect to the payments and benefits  described in (i) and (ii) above by Section
4999 of the Code.


                                        5

<PAGE>



                  For purposes of this Paragraph 6(h),  Executive's base amount,
the present  value of the Parachute  Payments,  the amount of the excise tax and
all other appropriate  matters shall be determined by the Company's  independent
auditors in accordance with the principles of Section 280G of the Code and based
upon the advice of tax counsel selected by the Company,  which tax counsel shall
be reasonably satisfactory to Executive.

         7.  Notice of Certain  Terminations.  In the event that  either (i) the
Company shall  terminate  Executive for Cause or (ii) Executive  shall terminate
for Good Reason,  then any such  termination  shall be  communicated  by written
notice to the other party hereto. Any such notice shall specify(x) the effective
date of  termination  of the  Employment  Period,  which,  except  as  otherwise
provided in  Paragraph  6(f),  shall not be more than 30 days after the date the
notice is delivered  (the  "Termination  Effective  Date" and (y) in  reasonable
detail  the  facts  and  circumstances   underlying  a  determination  that  the
termination  is for Cause or for Good  Reason,  as the case may be. If within 15
days after any notice of  termination  of Executive  for Cause by the Company is
given,  or if  within 15 days  after  the  Company's  30 day cure  period  under
Paragraph 6(f) has expired,  the party  receiving such notice notifies the other
party that a good faith dispute exists  concerning the  characterization  of the
termination,  the  Termination  Effective  Date  shall be the date on which such
dispute is finally  resolved  either by written  agreement  of the parties or by
binding arbitration  conducted pursuant to the rules of the American Arbitration
Association. Notwithstanding the pendency of any such dispute, the Company shall
continue Executive and his dependents as participants in all medical, dental and
any other health  insurance and similar benefit plans of the Company in which he
and they were  participating  when the notice  giving  rise to the  dispute  was
given,  until the  dispute is finally  resolved.  Benefits  provided  under this
Paragraph 7 are in addition to all other  amounts due under this  Agreement  and
shall not be  offset  against,  or reduce  any other  amounts  due  under,  this
Agreement.

         8.  Insurance.  The Company  may, at its  election and for its benefit,
insure Executive  against  accidental  death, and Executive shall submit to such
physical  examination  and  supply  such  information  as  may  be  required  in
connection therewith.

         9.       Non-disclosure of Confidential Information.

                  (a) Unless  Executive  first secures  written consent from the
Company  pursuant to  procedures  implemented  by Company after the date hereof,
Executive  shall not disclose or use at any time,  either during the  Employment
Period or thereafter,  any Confidential Information (as defined in Paragraph 17)
except to the extent Executive  reasonably  believes is necessary to disclose or
use  such  Confidential  Information  in  performing  the  Employment  Services.
Executive  further agrees that Executive will use  Executive's  commercial  best
efforts  to  safeguard  the  Confidential  Information  and  protect  it against
disclosure,  misuse, espionage,  loss and theft, including,  without limitation,
causing  recipients of  Confidential  Information  to enter into  non-disclosure
agreements with the Company.  Subject to the provisions of Paragraphs 10 and 13,
nothing herein shall be construed to prevent  Executive  from using  Executive's
general  knowledge  and  skill  after  termination  of this  Agreement,  whether
Executive  acquired  such  knowledge  or skill  before or during the  Employment
Period.


                                        6

<PAGE>



                  (b) In the event the Company has entered into  confidentiality
agreements with third parties (not including  Company  employees)  which contain
provisions  different from those set forth in this Agreement,  Executive agrees,
in  addition  to the  provisions  of  Paragraph  9(a),  to comply  with any such
different provisions of which Executive is notified by the Company.

         10.  Company  Ownership  of  Intellectual  Property.  Executive  hereby
assigns to the Company all right,  title and interest in and to all Intellectual
Property (as defined in  Paragraph  17)  contributed  to or conceived or made by
Executive during the Employment Period and prior to the Employment Period during
the period  Executive  was  employed by or engaged in  research  or  development
activities for or with the Company or its predecessors  and affiliates  (whether
alone or jointly  with others) to the extent such  Intellectual  Property is not
owned by the  Company as a matter of law.  Executive  shall  promptly  and fully
communicate to the Company all Intellectual  Property conceived,  contributed to
or made by  Executive  and shall  cooperate  with the  Company  to  protect  the
Company's interests in such Intellectual Property including, without limitation,
providing  assistance in securing patent protection and copyright  registrations
and signing all  documents  reasonably  requested by the  Company,  even if such
request occurs after the Employment  Period.  The Company shall pay  Executive's
reasonable  expenses of cooperating with the Company in protecting the Company's
interests  in such  Intellectual  Property  unless  the  subject  matter  of the
requested  cooperation  is  related  to  actions  taken or failed to be taken by
Executive wrongfully or otherwise not in good faith.

         11. Executive's  Rights.  Paragraph 10 of this Agreement does not apply
to an invention  for which no  equipment,  supplies,  facilities or trade secret
information  of the  Company  was used  and  which  was  developed  entirely  on
Executive's  own time,  unless (a) the invention  relates (i) to the business of
the  Company,  or (ii)  to the  Company's  actual  or  demonstrably  anticipated
material  research or  development,  or (b) the invention  results from any work
performed by Executive for the Company.

         12. Return of Materials.  Upon termination of the Employment Period, or
at any time  reasonably  requested  by the  Company,  Executive  shall  promptly
deliver to the Company all copies of  Confidential  Information  in  Executive's
possession  and control,  including  written  records,  manuals,  lab notebooks,
customer and supplier lists and all other materials  containing any Confidential
Information.   If  the  Company   requests,   Executive  shall  provide  written
confirmation  that  Executive  has returned all such  materials.  Subject to the
provisions  of this  Agreement,  including,  without  limitation,  Paragraph 11,
notwithstanding  anything in this Agreement to the contrary, upon termination of
the  Employment  Period,  the Company,  at Executive's  request,  shall promptly
return to Executive any  equipment or other  materials  owned by Executive  then
being used by or then in the possession of the Company.

         13. Non-Competition.  Executive acknowledges and agrees that during the
Employment  Period and for a period of five years  thereafter (the  "Non-compete
Period"),  Executive will not, without the prior written consent of the Company,
directly or indirectly,  provide products or services  substantially  similar to
the  Employment  Services to any  business or entity that  provides or offers or
demonstrably  plans to provide or offer,  products or services  that (i) are the
same as or  substantially  similar to the  products or services  provided by the
Company at any time during the Employment  Period,  (ii) relate to the Company's
Intellectual Property (whether the Company acquired such

                                        7

<PAGE>



Intellectual Property pursuant to this Agreement or otherwise),  or (iii) relate
to any  subject  matter  of the  Company's  actual or  demonstrably  anticipated
material  research  and  development  during the  Employment  Period,  including
without  limitation,   taxol,  taxanes  and  any  other  compounds,  within  any
geographical  area in which the  Company or any of its  subsidiaries  provide or
plan to provide such products or services.

         14. Non-Solicitation. Executive acknowledges and agrees that during the
Non-compete Period Executive will not (a) solicit,  induce or attempt to induce,
directly or  indirectly,  any employee of the Company to leave the employment of
the Company to work for Executive or for any other person,  firm or  corporation
or (b) hire any employee of the Company.

         15. Acknowledgment of Reasonableness. Executive acknowledges and agrees
that the  limitations  set forth in  Paragraphs  13 and 14 are  reasonable  with
respect to scope, duration and geographic area and are properly required for the
protection of the legitimate business interest of the Company.

         16. Further Assistance.  During the Non-compete Period,  Executive will
not make any disclosure or other  communication to any person,  issue any public
statements or otherwise cause to be disclosed any information which is designed,
intended or might reasonably be anticipated to discourage any persons from doing
business with the Company or otherwise have a negative  impact or adverse effect
on the Company,  except to the extent such disclosure is required by law. During
the Non-compete Period,  Executive will provide assistance  reasonably requested
by the  Company  in  connection  with  actions  taken by  Executive  during  the
Employment  Period,  including but not limited to assistance in connection  with
any lawsuits or other claims against the Company  arising from events during the
Employment  Period,  provided  that the Company shall  reimburse all  reasonable
expenses  (including  without  limitation,  reasonable loss of compensation from
other sources resulting from such assistance during normal business hours).

         17.      Certain Definitions.

                  "Affiliate"  means  a  person  that  directly,  or  indirectly
through one or more intermediaries,  controls,  or is controlled by, or is under
common control with, the person specified.

                  "Confidential  Information" means all information  (whether or
not specifically labeled or identified as confidential),  in any form or medium,
that is disclosed to, or developed or learned by Executive during the Employment
Period  and prior to the  Employment  Period  during the  period  Executive  was
employed  by or engaged in research or  development  activities  for or with the
Company or its  predecessors  and  affiliates  or that relates to the  business,
products,  services,  customers,  research or  development  of the Company,  its
Subsidiaries,  its  Affiliates,  or third  parties  with whom the  Company,  its
Subsidiaries  or its  Affiliates  does  business or from whom the Company or its
Affiliates receives information.  Confidential Information shall not include any
information that (i) has become publicly known through no wrongful act or breach
of any  obligation  of  confidentiality,  as  evidenced  by  written  records or
documents;  or (ii) was rightfully  received by Executive on a  non-confidential
basis  from a third  party  (provided  that  such  third  party is not  known to
Executive to be bound by a confidentiality agreement with the Company or another
party), as evidenced by written records or documents.

                                        8

<PAGE>



                  "Independent  Third  Party"  means  any  person,  including  a
"group" as defined in Section  13(d)(3) of the Securities  Exchange Act of 1934,
as amended, and the rules and regulations thereunder,  who, immediately prior to
the  contemplated  transaction,  does not own in excess  of 5% of the  Company's
Common Stock on a fully-diluted basis, who is not controlling,  controlled by or
under common  control with any such 5% owner of the  Company's  Common Stock and
who is not the spouse or descendent  (by birth or adoption) of any such 5% owner
of the Company's Common Stock.

                  "Intellectual  Property"  means any idea,  invention,  design,
development,  device, method or process (whether or not patentable or reduced to
practice or  including  Confidential  Information)  and all related  patents and
patent  applications,  any  copyrightable  work or  mask  work  (whether  or not
including   Confidential   Information)  and  all  related   registrations   and
applications for registration, and all other proprietary rights.

                  "Subsidiaries"  means any  corporation of which the securities
having a majority of the voting power in electing  directors are, at the time of
determination,   owned  by  the  Company,   directly  or  through  one  of  more
Subsidiaries.

     18. Executive Representations.  Executive hereby represents and warrants to
the Company that (a) the execution,  delivery and  performance of this Agreement
by Executive  does not and will not conflict  with,  breach,  violate or cause a
default under any contract, agreement,  instrument, order, judgment or decree to
which  Executive is a party or by which he is bound,  and (b) upon the execution
and delivery of this Agreement by the Company, this Agreement shall be the valid
and binding obligation of Executive, enforceable in accordance with its terms.

     19. Company Representations.  The Company hereby represents and warrants to
Executive that (a) the execution,  delivery and performance of this Agreement by
the Company  does not and will not  conflict  with,  breach,  violate or cause a
default under any contract, agreement,  instrument, order, judgment or decree to
which Company is a party or by which it is bound, and (b) upon the execution and
delivery of this Agreement by Executive,  this Agreement  shall be the valid and
binding obligation of the Company, enforceable in accordance with its terms.

     20. Severability and Modification. If any provision of this Agreement shall
be held or declared  to be  illegal,  invalid or  unenforceable,  such  illegal,
invalid or unenforceable  provision shall not affect any other provision of this
Agreement,  and the remainder of this Agreement shall continue in full force and
effect as though such provision had not been contained in this Agreement. If the
scope of any  provision  in this  Agreement  is found to be too  broad to permit
enforcement of such provision to its full extent, Executive consents to judicial
modification of such provision and  enforcement to the maximum extent  permitted
by law.

     21. Notices. Except as otherwise expressly set forth in this Agreement, all
notices,  requests and other communications to be given or delivered under or by
reason of the  provisions  of this  Agreement  shall be in writing  and shall be
given (and, except as otherwise  provided in this Agreement,  shall be deemed to
have  been  duly  given if so  given)  when  delivered  if given in person or by
telegram,  three days after being mailed by first class  registered or certified
mail,  return receipt  requested,  postage prepaid,  or one day after being sent
prepaid via reputable overnight courier to the

                                        9

<PAGE>



parties at the following  addresses (or such other address as shall be furnished
in writing by like notice;  provided,  however, that notice of change of address
shall be effective only upon receipt):

Notices to Executive
         Sterling K. Ainsworth, Ph.D.
         c/o NaPro BioTherapeutics, Inc.
         6304 Spine Road, Unit A
         Boulder, Colorado  80301

Notices to Company
         NaPro BioTherapeutics,
         6304 Spine Road, Unit A
         Boulder, Colorado 80301

         Attn.:   Patricia A. Pilia, Ph.D.
                  Executive Vice President

         with a copy to:
         Holme Roberts & Owen
         1700 Lincoln, Suite 4100
         Denver, CO 80203

         Attn.:  Francis Wheeler

     22. Entire Agreement.  This Agreement contains the entire agreement between
the  parties  with  respect to the  subject  matter  hereof and  supersedes  any
previous  understandings or agreements,  whether written or oral, regarding such
subject matter, including but not limited to the Prior Agreement.

     23. Governing Law. All questions concerning the construction,  validity and
interpretations  of this Agreement will be governed by the internal law, and not
the law of conflicts, of the State of Colorado.

     24.  Survival.  Paragraphs  6, 9, 10,  11,  12, 13, 14 and 16 and any other
provision of this Agreement which by its terms could survive  termination of the
Employment  Period shall survive and continue in full force in  accordance  with
their terms notwithstanding any termination of the Employment Period.

     25. Counterparts.  This Agreement may be executed in separate counterparts,
each of which is  deemed  to be an  original  and all of  which  taken  together
constitute one and the same agreement.

     26. Successors and Assigns. This Agreement is intended to bind and inure to
the benefit of and be enforceable by Executive, the Company and their respective
successors and assigns;  provided that in no event shall Executive's obligations
under this  Agreement  be  delegated  or  transferred  by  Executive,  nor shall
Executive's rights be subject to encumbrance or to the claims of

                                       10

<PAGE>



Executive's  creditors.  This  Agreement  is for the sole benefit of the parties
hereto and shall not create any rights in third parties  other than  Executive's
spouse or beneficiary as expressly set forth herein.

     27. Remedies.  Except as otherwise provided in this Agreement,  (i) each of
the parties to this  Agreement will be entitled to enforce its rights under this
Agreement  specifically,  to  recover  damages  by reason  of any  breach of any
provision of this  Agreement and to exercise all other rights to which it may be
entitled and (ii) disputes under this Agreement not finally  resolved in writing
by the parties  within  sixty days after one party gives notice in good faith to
the other party that a bona fide dispute  exists  shall be resolved  pursuant to
binding arbitration  conducted in Denver,  Colorado in accordance with the rules
of the  American  Arbitration  Association.  The  prevailing  party  in any such
arbitration  shall  be  entitled  to have  its  costs  and  expenses  (including
reasonable  attorney's fees and expenses)  relating to such  arbitration paid by
the other party if the  arbitrator(s)  conducting such arbitration so determine.
Notwithstanding  the  foregoing,  the parties agree and  acknowledge  that money
damages  may not be an  adequate  remedy  for breach of the  provisions  of this
Agreement  and that any party may in its sole  discretion  apply to any court of
law  or  equity  of  competent  jurisdiction  for  specific  performance  and/or
injunctive  relief  in  order  to  enforce  or  prevent  any  violations  of the
provisions of this Agreement. The prevailing party in any suit shall be entitled
to recover reasonable attorneys fees and costs from the other party.

     28.  Modifications  and  Waivers.  No provision  of this  Agreement  may be
modified,  altered or amended except by an instrument in writing executed by the
parties  hereto.  No waiver by either  party  hereto of any  breach by the other
party hereto of any term or provision of this  Agreement to be performed by such
other  party  shall  be  deemed a  waiver  of  similar  or  dissimilar  terms or
provisions at the time or at any prior or subsequent time.

     29. Headings.  The headings  contained herein are solely for the purpose of
reference,  are not part of this  Agreement  and shall not in any way affect the
meaning or interpretation of this Agreement.

     30. Notification of Subsequent Employer.  Executive agrees that the Company
may present a copy of this Agreement to any third party.

     31.  UNDERSTAND  AGREEMENT.  EXECUTIVE  REPRESENTS  AND  WARRANTS  THAT (a)
EXECUTIVE HAS READ AND UNDERSTOOD  EACH AND EVERY  PROVISION OF THIS  AGREEMENT,
(b)  EXECUTIVE  HAS HAD THE  OPPORTUNITY  TO OBTAIN ADVICE FROM LEGAL COUNSEL OF
EXECUTIVE'S  CHOICE,  OTHER THAN COUNSEL TO THE COMPANY (WHO IS NOT REPRESENTING
THE EXECUTIVE),  IN ORDER TO INTERPRET ANY AND ALL PROVISIONS OF THIS AGREEMENT,
(c) EXECUTIVE HAS HAD THE  OPPORTUNITY TO ASK THE COMPANY  QUESTIONS  ABOUT THIS
AGREEMENT  AND ANY OF SUCH  QUESTIONS  EXECUTIVE HAS ASKED HAVE BEEN ANSWERED TO
EXECUTIVE'S  SATISFACTION,  AND  (d)  EXECUTIVE  HAS  BEEN  GIVEN A COPY OF THIS
AGREEMENT.


                                       11

<PAGE>


         IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
duly executed on the day and year first above written.

                                EXECUTIVE

                                         /s/ Sterling K. Ainsworth
                                -----------------------------------
                                         Sterling K. Ainsworth


                                NAPRO BIOTHERAPEUTICS, INC.


                                By:______/s/ Gordon H. Link, Jr._____
                                         Gordon H. Link, Jr.
                                         Vice President, Finance and
                                         Chief Financial Officer


                                       12

<PAGE>



                          AMENDED EMPLOYMENT AGREEMENT

     THIS AGREEMENT (the  "Agreement") is entered into effective this 5th day of
October,  1998 (the  "Effective  Date"),  by and between NaPro  BioTherapeutics,
Inc.,  a  Delaware   corporation   (the   "Company"),   and  Patricia  A.  Pilia
("Executive"). Certain capitalized terms used in this Agreement have the meaning
set forth in Paragraph 17 hereof.

                                    RECITALS

     A. WHEREAS,  the Company and the Executive have previously  entered into an
Amended and Restated Employment and Executive Stock Agreement,  dated as of June
7, 1993 and amended  and  restated  effective  as of May 31,  1994,  (the "Prior
Agreement"); and

     B.  WHEREAS,  the  Company  desires to secure  the  continued  services  of
Executive as an employee of the Company, and to provide for certain compensation
and benefit  arrangements for Executive in the event of Executive's  termination
of  employment  under certain  circumstances,  and Executive is willing to enter
into this Agreement and perform such services.

                              TERMS AND CONDITIONS

     In consideration of the respective  covenants and agreements of the parties
contained  in this  Agreement,  the  parties  agree to amend and  restate in its
entirety the Prior Agreement as follows:

     1. Employment Services. The Company hereby agrees to engage Executive,  and
Executive  hereby agrees to perform  services for the Company,  on the terms and
conditions set forth in this Agreement. During the Employment Period (as defined
below),  the  Company  and  Executive  agree  that  Executive  will  serve as an
executive  officer of the Company in the  position of Executive  Vice  President
with the duties,  responsibilities  and authority as set forth on Schedule A, or
will  have  such  other  executive  title  and  such  other  executive   duties,
responsibilities  and authority as Executive and the Company may agree upon from
time to time, and will perform such services of an executive and  administrative
character to the Company and its present or future Subsidiaries  consistent with
the duties of the Company's other executive officers,  as the Company's Board of
Directors (the "Board") may from time to time direct (the "Employment Services")
or the Bylaws of the Company may provide. The Employment Services shall commence
upon the Effective Date of this Agreement and terminate as provided in Paragraph
6 (the "Employment Period").

         2.       Performance.

     (a) Executive shall report to the Chief Executive Officer (or person acting
in a similar  capacity  if the  Company  has no Chief  Executive  Officer),  and
Executive shall devote her best efforts and her full business time and attention
(except  for  permitted  vacation  periods) to the  business  and affairs of the
Company and its Subsidiaries;  provided,  however,  that upon prior agreement by
the  Chief  Executive  Officer,  and  subject  to the  terms of this  Agreement,
Executive  may  engage  in  independent  activities  in areas  unrelated  to the
Company's business or the Company's actual or demonstrably anticipated business;
and provided,  further,  that no such  independent  activities  shall materially
detract from the  essentially  full time commitment of Executive to the business
and  affairs  of  the   Company.   Executive   shall   perform  her  duties  and
responsibilities to the best of her abilities


<PAGE>



in a diligent, trustworthy, businesslike and professional manner.

                  (b)  Unless  the  Company  and  Executive   otherwise   agree,
Executive  shall  perform the  Employment  Services at the  Company's  executive
offices and traveling on business as Executive and the Company shall  reasonably
deem necessary.

         3.       Compensation.

                  (a)  During  the  Employment  Period,  the  Company  will  pay
Executive for the  Employment  Services a base salary (the "Base Salary") at the
annual  rate  of  $135,000  or such  other  increased  rate as the  compensation
committee of the Board or Board committee  performing  equivalent functions (the
"Compensation  Committee") (or if the Board has no Compensation Committee at the
time, then the Board) may designate from time to time, such salary to be paid at
such periods as salary is paid to other executive  officers of the Company.  The
Compensation  Committee  (or the Board,  if  applicable)  shall  review the Base
Salary of the Executive at least  annually on the  anniversary  of the Effective
Date and may, in its sole  discretion,  increase  (but not  decrease)  such Base
Salary  from time to time.  Payment of the Base  Salary  shall be subject to the
customary withholding tax and other employment taxes as required with respect to
compensation paid by a corporation to an employee.

                  (b) Executive  may receive an annual bonus in such amount,  if
any,  as  the  Compensation  Committee  (or  if the  Board  has no  Compensation
Committee  at the  time,  then  the  Board),  in its  discretion,  may  award to
Executive, based upon Executive's and the Company's performance during each year
of the Employment  Period,  provided,  however that each annual bonus payable to
Executive during the Employment Period shall not be less than the greater of (i)
$20,000 or (ii) the amount of the highest annual bonus paid to Executive for the
three most recent fiscal years of the Company.

                  (c) The  Executive  shall be  entitled  to receive  such stock
options  during the  Employment  Period as  determined  from time to time by the
Compensation  Committee  (or if the Board has no  Compensation  Committee at the
time, then the Board).

         4.  Reimbursement  for Expenses.  The Company shall promptly  reimburse
Executive  for all  reasonable  out-of-pocket  expenses  incurred  by her in the
course of performing her duties under this  Agreement,  subject to the Company's
reasonable  requirements  with respect to reporting  and  documentation  of such
expenses.

         5. Benefits. Executive shall be entitled to all fringe benefits offered
by the Company  and to  participate  in all of the  Company's  employee  benefit
programs both on the same basis as available to  executives of the Company,  and
shall be  entitled  to such  other  benefits  as may  from  time to time be made
available to  Executive.  The Company  shall use  commercially  reasonable  best
efforts to obtain and keep directors' and officers' liability insurance coverage
in effect in an amount equivalent to that of a well-insured,  similarly-situated
company;  provided,  however, that the failure to obtain and keep such insurance
in effect after the Company has  exercised  such  commercially  reasonable  best
efforts shall not be a breach of the Company's obligations under this Agreement.
During the Employment Period,  Executive shall be entitled to four weeks of paid
vacation during

                                        2

<PAGE>



each  year of the  Employment  Period  and may  carry  over up to four  weeks of
vacation from one year to the next succeeding year only.

         6.       Term and Termination.

                  (a)  Except  as  otherwise  provided  in this  Agreement,  the
Employment Period shall terminate upon the earlier of:

     (i) three  years from the  Effective  Date  hereof  (the  "Initial  Term");
provided,  however,  that  commencing  on the date one year after the  Effective
Date,  and on each  annual  anniversary  of such date (such date and each annual
anniversary  thereof shall be  hereinafter  referred to as the "Renewal  Date"),
unless  previously  terminated,  the  Employment  Period shall be  automatically
extended so as to terminate  three years from such Renewal  Date,  unless either
Executive  or the Board  shall have given  written  notice to the other party no
later than 180 days prior to the Renewal Date that the  Employment  Period shall
not be so extended;

     (ii) Executive's  incapacity or permanent  disability (which in either case
shall be deemed to occur only in the event  Executive  is unable to perform  the
Employment Services for 180 days in any 12-month period) or death;

     (iii)  termination by Executive  voluntarily or for Good Reason (as defined
below);

     (iv) termination by the Company with or without Cause (as defined below).

                  (b) If the Employment  Period is terminated (i) by the Company
without  Cause or (ii) by Executive  for Good Reason,  then  Executive  shall be
entitled to receive,  so long as Executive  has not breached the  provisions  of
Paragraphs  9, 10,  12, 13,  14, or 16 hereof in a manner  that could  adversely
affect  the  Company,  his  Base  Salary  in cash at the  periods  set  forth in
Paragraph 3, at a rate equal to the then  applicable rate set forth in Paragraph
3 for a period  equal to the  greater  of (x) the  remainder  of the  Employment
Period,  but not in excess of three  years or (y) two years plus in either  case
(I) the  greater  of (A) the  most  recent  annual  bonus,  if any,  awarded  to
Executive  pursuant to  Paragraph  3(b) during the  Company's  fiscal year of or
during the Company's  fiscal year prior to termination,  as the case may be, (B)
the  average  amount  of the last  three  annual  bonuses,  if any,  awarded  to
Executive  pursuant to  Paragraph  3(b) prior to  termination,  or (C)  $20,000,
multiplied by in any case not less than the number of years for which  Executive
is entitled to receive his Base Salary pursuant to this Paragraph 6(b) (prorated
for any partial  year) (such bonus amounts to be paid pro rata over the term for
which  Executive  is  entitled  to  receive  his Base  Salary  pursuant  to this
Paragraph  6(b));  plus (II) at Executive's  election,  medical,  dental and any
other health  insurance,  life  insurance,  accidental  death and  dismemberment
insurance  and  disability  protection  no less  favorable to Executive  and his
dependents  covered thereby  (including that Executive shall remain obligated to
continue  to pay any  costs or  expenses  which  Executive  would  otherwise  be
obligated  to pay  pursuant  to such  insurance  or other  protections  provided
pursuant to Paragraph 5 as in existence on the date of such  termination)  until
the first to occur of (i) the date of

                                        3

<PAGE>



Executive's  re-employment  and  subsequent  opportunity  to  participate in any
health insurance program with comparable coverage provided by such new employer,
including  without  limitation,   coverage  with  respect  to  any  pre-existing
conditions or (ii) eighteen months after such termination date.

                  (c) If a Change of  Control  (as  defined  below)  occurs  and
Executive  is  thereafter  offered and  accepts  continued  employment  with the
Company (or its successor),  and either (i) she is still employed by the Company
on the  first  calendar  anniversary  of the  Change  of  Control,  or (ii)  her
employment  with the Company is terminated  by the Company  without Cause or she
terminates  her  employment  for Good Reason  during such one year  period,  the
Company shall pay Executive, in addition to any other amounts payable hereunder,
a "stay bonus"  equal to one year's then current Base Salary.  Such "stay bonus"
shall be paid in a cash lump sum to Executive  within twenty (20) days following
the earlier of (i) the first anniversary of the date of the Change of Control or
(ii) the date of her termination of employment with the Company. For purposes of
this  Agreement,  a  "Change  of  Control"  means  the  happening  of any of the
following:  (i) the merger or  consolidation of the Company into a new surviving
company  in  which  the  holders  of  the  Company's  voting  securities  (on  a
fully-diluted  basis)  immediately prior to the merger or consolidation own less
than a majority  of the  ordinary  voting  power to elect  directors  of the new
surviving  company  (on a fully  diluted  basis),  or (ii) when any  "person" as
defined in Section 3(a)(9) of the Securities Exchange Act of 1934 (the "34 Act")
and as used in Sections 13(d) and 14(d) thereof,  including a "group" as defined
in Section 13(d) of the 34 Act but  excluding the Company and any  Subsidiary or
any  employee  benefit  plan  sponsored  or  maintained  by the  Company  or any
Subsidiary  (including  a trustee of such plan acting as  trustee),  directly or
indirectly,  becomes the "beneficial  owner" (as defined in Rule 13d-3 under the
34 Act, as amended from time to time), of securities of the Company representing
25% or more of the  combined  voting  power of the  Company's  then  outstanding
securities.

                  (d)  Except  as  provided  in  Paragraphs  6(b) or  (c),  upon
termination of the  Employment  Period,  Executive  shall be entitled to receive
only  (i)  accrued  but  unpaid  salary  and  bonus  through  the  date  of such
termination and (ii) unpaid salary with respect to any vacation days accrued but
not taken as of the date of such termination.

                  (e) For purposes of this Agreement, "Cause" shall mean (i) the
conviction (or plea of nolo  contendere) of a felony or a crime  involving moral
turpitude or the  commission of any other act which has an adverse effect on the
Company and which involves  dishonesty,  disloyalty or fraud with respect to the
Company or any of its Subsidiaries,  (ii) conduct bringing the Company or any of
its  Subsidiaries  into  substantial  public  disgrace or disrepute,  including,
without limitation, such conduct resulting from repeated acts of alcohol or drug
abuse, (iii) continued failure by Executive to substantially  perform her duties
as reasonably  directed by the Board for a period of 15 days after the Board has
made a demand for  substantial  performance  which  specifically  identifies the
manner  in  which  the  Board  believes  that  Executive  has not  substantially
performed her duties,  or (iv) gross  negligence or misconduct not in good faith
with  respect  to the  Company  or any of its  Subsidiaries,  or (v)  any  other
material  breach  of this  Agreement  which is not cured  within  15 days  after
Executive's receipt of written notice thereof.

                                        4

<PAGE>



     (f) For purposes of this Agreement, termination of the Employment Period by
Executive for "Good Reason"  shall mean  termination  by Executive (i) within 90
days after  Executive  has been  assigned,  without her  consent,  to any duties
substantially inconsistent with her position, duties, responsibilities or status
with the Company as contemplated in Paragraph 1 of this Agreement; (ii) upon 120
days' prior written notice if such notice is given within 30 days after the date
Executive  ceases,  without  her  consent,  to be a member of the  Board;  (iii)
following a Change of Control,  upon failure of the Company to pay  Executive an
annual bonus equal to the average  amount of such annual bonus paid to Executive
during the three fiscal years of the Company  immediately  preceding the year in
which the Change of Control  occurs;  (iv)  following a reduction of Executive's
Base Salary after a Change of Control; (v) if Executive is required to regularly
perform the duties of her employment more than 50 miles from Boulder,  Colorado;
or (vi) upon a material  breach of this  Agreement  by the Company  which is not
cured  within 30 days after the  Company's  receipt of written  notice  thereof.
Executive  shall  provide  written  notice to the Company of any and all grounds
that Executive  alleges  constitute  "Good Reason" and the Company shall have 30
days after receipt of such written  notice to cure any such alleged  grounds for
"Good Reason".  If,  following the  expiration of such 30 day period,  Executive
still believes that "Good Reason" exists for her termination of Employment,  the
provisions of Paragraph 7 shall apply.

     (g) Promptly (but in any event within 20 days) following any termination of
the Employment Period, and as of that date, the Company will notify Executive of
the  itemized  and  aggregate  cash  value  of the  payments  and  benefits,  as
determined  under  Section  280G of the  Internal  Revenue  Code  (the  "Code"),
received or to be received by Executive in connection  with the  termination  of
her  employment  (whether  payable  pursuant to the terms of this  Agreement  or
otherwise).  At the same time, the Company shall advise Executive of the portion
of such payments or benefits  which  constitute  parachute  payments  within the
meaning of the Code and which may  subject  Executive  to the  payment of excise
taxes  pursuant  to Section  4999 and the  expected  amount of such taxes  (such
payments or benefits being hereinafter referred to as "Parachute Payments").

     (h)  Notwithstanding the provisions of Paragraph 6(b) hereof, if all or any
portion of the payments or benefits  provided under  Paragraph 6(b) either alone
or together with other payments or benefits  which  Executive has received or is
then  entitled to receive  from the Company  and any of its  Subsidiaries  would
constitute  Parachute Payments,  such payments or benefits provided to Executive
under Paragraph 6(b) shall be reduced to the extent necessary so that no portion
thereof  shall be subject to the excise tax imposed by Section 4999 of the Code;
but only if, by  reason of such  reduction,  Executive's  net after tax  benefit
shall  exceed the net after tax benefit if such  reduction  were not made.  "Net
after tax benefit" for purposes of this Paragraph 6(h) shall mean the sum of (i)
the total amount payable to Executive under Paragraphs 6(b) and (c) hereof, plus
(ii) all other  payments and benefits  which  Executive  has received or is then
entitled  to receive  from the Company  and any of its  subsidiaries  that would
constitute a Parachute  Payment,  less (iii) the amount of federal  income taxes
payable with respect to the payment and benefits described in (i) and (ii) above
calculated at the maximum  marginal  income tax rate for each year in which such
payments and benefits shall be paid to Executive  (based upon the rate in effect
for such year as set forth in the Code at the Termination  Date),  less (iv) the
amount of excise  taxes  imposed  with  respect  to the  payments  and  benefits
described in (i) and (ii) above by Section 4999 of the Code.

     For purposes of this Paragraph 6(h),  Executive's base amount,  the present
value of the  Parachute  Payments,  the  amount of the  excise tax and all other
appropriate matters shall be

                                        5

<PAGE>



determined  by  the  Company's  independent  auditors  in  accordance  with  the
principles  of Section 280G of the Code and based upon the advice of tax counsel
selected by the Company,  which tax counsel shall be reasonably  satisfactory to
Executive.

         7.  Notice of Certain  Terminations.  In the event that  either (i) the
Company shall  terminate  Executive for Cause or (ii) Executive  shall terminate
for Good Reason,  then any such  termination  shall be  communicated  by written
notice to the other party hereto. Any such notice shall specify(x) the effective
date of  termination  of the  Employment  Period,  which,  except  as  otherwise
provided in  Paragraph  6(f),  shall not be more than 30 days after the date the
notice is delivered (the "Termination Effective Date"); (y) in reasonable detail
the facts and circumstances  underlying a determination  that the termination is
for Cause or for Good  Reason,  as the case may be. If within 15 days  after any
notice of  termination  of  Executive  for Cause by the Company is given,  or if
within 15 days after the Company's 30 day cure period under  Paragraph  6(f) has
expired,  the party  receiving such notice  notifies the other party that a good
faith dispute exists  concerning the  characterization  of the termination,  the
Termination  Effective  Date shall be the date on which such  dispute is finally
resolved  either by written  agreement of the parties or by binding  arbitration
conducted  pursuant  to the  rules  of  the  American  Arbitration  Association.
Notwithstanding  the pendency of any such dispute,  the Company  shall  continue
Executive and her  dependents  as  participants  in all medical,  dental and any
other health insurance and similar benefit plans of the Company in which she and
they were  participating  when the notice  giving rise to the dispute was given,
until the dispute is finally resolved.  Benefits provided under this Paragraph 7
are in addition to all other  amounts due under this  Agreement and shall not be
offset against, or reduce any other amounts due under, this Agreement.

         8.  Insurance.  The Company  may, at its  election and for its benefit,
insure Executive  against  accidental  death, and Executive shall submit to such
physical  examination  and  supply  such  information  as  may  be  required  in
connection therewith.

         9.       Non-disclosure of Confidential Information.

     (a)  Unless  Executive  first  secures  written  consent  from the  Company
pursuant to procedures  implemented by Company after the date hereof,  Executive
shall not disclose or use at any time,  either during the  Employment  Period or
thereafter,  any Confidential Information (as defined in Paragraph 17) except to
the extent  Executive  reasonably  believes is necessary to disclose or use such
Confidential  Information  in  performing  the  Employment  Services.  Executive
further agrees that Executive will use  Executive's  commercial  best efforts to
safeguard  the  Confidential  Information  and  protect it  against  disclosure,
misuse,  espionage,  loss and  theft,  including,  without  limitation,  causing
recipients of Confidential  Information to enter into non-disclosure  agreements
with the Company.  Subject to the  provisions of  Paragraphs 10 and 13,  nothing
herein shall be construed to prevent  Executive from using  Executive's  general
knowledge  and skill after  termination  of this  Agreement,  whether  Executive
acquired such knowledge or skill before or during the Employment Period.

     (b) In the event the Company has entered  into  confidentiality  agreements
with third parties (not including  Company  employees) which contain  provisions
different from those set forth in this Agreement,  Executive agrees, in addition
to the  provisions  of  Paragraph  9(a),  to  comply  with  any  such  different
provisions of which Executive is notified by the Company.

                                        6

<PAGE>

         10.  Company  Ownership  of  Intellectual  Property.  Executive  hereby
assigns to the Company all right,  title and interest in and to all Intellectual
Property (as defined in  Paragraph  17)  contributed  to or conceived or made by
Executive during the Employment Period and prior to the Employment Period during
the period  Executive  was  employed by or engaged in  research  or  development
activities for or with the Company or its predecessors  and affiliates  (whether
alone or jointly  with others) to the extent such  Intellectual  Property is not
owned by the  Company as a matter of law.  Executive  shall  promptly  and fully
communicate to the Company all Intellectual  Property conceived,  contributed to
or made by  Executive  and shall  cooperate  with the  Company  to  protect  the
Company's interests in such Intellectual Property including, without limitation,
providing  assistance in securing patent protection and copyright  registrations
and signing all  documents  reasonably  requested by the  Company,  even if such
request occurs after the Employment  Period.  The Company shall pay  Executive's
reasonable  expenses of cooperating with the Company in protecting the Company's
interests  in such  Intellectual  Property  unless  the  subject  matter  of the
requested  cooperation  is  related  to  actions  taken or failed to be taken by
Executive wrongfully or otherwise not in good faith.

         11. Executive's  Rights.  Paragraph 10 of this Agreement does not apply
to an invention  for which no  equipment,  supplies,  facilities or trade secret
information  of the  Company  was used  and  which  was  developed  entirely  on
Executive's  own time,  unless (a) the invention  relates (i) to the business of
the  Company,  or (ii)  to the  Company's  actual  or  demonstrably  anticipated
material  research or  development,  or (b) the invention  results from any work
performed by Executive for the Company.

         12. Return of Materials.  Upon termination of the Employment Period, or
at any time  reasonably  requested  by the  Company,  Executive  shall  promptly
deliver to the Company all copies of  Confidential  Information  in  Executive's
possession  and control,  including  written  records,  manuals,  lab notebooks,
customer and supplier lists and all other materials  containing any Confidential
Information.   If  the  Company   requests,   Executive  shall  provide  written
confirmation  that  Executive  has returned all such  materials.  Subject to the
provisions  of this  Agreement,  including,  without  limitation,  Paragraph 11,
notwithstanding  anything in this Agreement to the contrary, upon termination of
the  Employment  Period,  the Company,  at Executive's  request,  shall promptly
return to Executive any  equipment or other  materials  owned by Executive  then
being used by or then in the possession of the Company.

         13. Non-Competition.  Executive acknowledges and agrees that during the
Employment  Period and for a period of five years  thereafter (the  "Non-compete
Period"),  Executive will not, without the prior written consent of the Company,
directly or indirectly,  provide products or services  substantially  similar to
the  Employment  Services to any  business or entity that  provides or offers or
demonstrably  plans to provide or offer,  products or services  that (i) are the
same as or  substantially  similar to the  products or services  provided by the
Company at any time during the Employment  Period,  (ii) relate to the Company's
Intellectual  Property (whether the Company acquired such Intellectual  Property
pursuant to this Agreement or otherwise),  or (iii) relate to any subject matter
of the  Company's  actual or  demonstrably  anticipated  material  research  and
development during the Employment Period,  including without limitation,  taxol,
taxanes and any other compounds, within

                                        7

<PAGE>



any geographical area in which the Company or any of its subsidiaries provide or
plan to provide such products or services.

         14. Non-Solicitation. Executive acknowledges and agrees that during the
Non-compete Period Executive will not (a) solicit,  induce or attempt to induce,
directly or  indirectly,  any employee of the Company to leave the employment of
the Company to work for Executive or for any other person,  firm or  corporation
or (b) hire any employee of the Company.

         15. Acknowledgment of Reasonableness. Executive acknowledges and agrees
that the  limitations  set forth in  Paragraphs  13 and 14 are  reasonable  with
respect to scope, duration and geographic area and are properly required for the
protection of the legitimate business interest of the Company.

         16. Further Assistance.  During the Non-compete Period,  Executive will
not make any disclosure or other  communication to any person,  issue any public
statements or otherwise cause to be disclosed any information which is designed,
intended or might reasonably be anticipated to discourage any persons from doing
business with the Company or otherwise have a negative  impact or adverse effect
on the Company,  except to the extent such disclosure is required by law. During
the Non-compete Period,  Executive will provide assistance  reasonably requested
by the  Company  in  connection  with  actions  taken by  Executive  during  the
Employment  Period,  including but not limited to assistance in connection  with
any lawsuits or other claims against the Company  arising from events during the
Employment  Period,  provided  that the Company shall  reimburse all  reasonable
expenses  (including  without  limitation,  reasonable loss of compensation from
other sources resulting from such assistance during normal business hours).

         17.      Certain Definitions.

                  "Affiliate"  means  a  person  that  directly,  or  indirectly
through one or more intermediaries,  controls,  or is controlled by, or is under
common control with, the person specified.

                  "Confidential  Information" means all information  (whether or
not specifically labeled or identified as confidential),  in any form or medium,
that is disclosed to, or developed or learned by Executive during the Employment
Period  and prior to the  Employment  Period  during the  period  Executive  was
employed  by or engaged in research or  development  activities  for or with the
Company or its  predecessors  and  affiliates  or that relates to the  business,
products,  services,  customers,  research or  development  of the Company,  its
Subsidiaries,  its  Affiliates,  or third  parties  with whom the  Company,  its
Subsidiaries  or its  Affiliates  does  business or from whom the Company or its
Affiliates receives information.  Confidential Information shall not include any
information that (i) has become publicly known through no wrongful act or breach
of any  obligation  of  confidentiality,  as  evidenced  by  written  records or
documents;  or (ii) was rightfully  received by Executive on a  non-confidential
basis  from a third  party  (provided  that  such  third  party is not  known to
Executive to be bound by a confidentiality agreement with the Company or another
party), as evidenced by written records or documents.

                  "Independent  Third  Party"  means  any  person,  including  a
"group" as defined in Section  13(d)(3) of the Securities  Exchange Act of 1934,
as amended, and the rules and regulations

                                        8

<PAGE>



thereunder, who, immediately prior to the contemplated transaction, does not own
in excess of 5% of the Company's  Common Stock on a fully-diluted  basis, who is
not controlling, controlled by or under common control with any such 5% owner of
the Company's  Common Stock and who is not the spouse or descendent (by birth or
adoption) of any such 5% owner of the Company's Common Stock.

                  "Intellectual  Property"  means any idea,  invention,  design,
development,  device, method or process (whether or not patentable or reduced to
practice or  including  Confidential  Information)  and all related  patents and
patent  applications,  any  copyrightable  work or  mask  work  (whether  or not
including   Confidential   Information)  and  all  related   registrations   and
applications for registration, and all other proprietary rights.

                  "Subsidiaries"  means any  corporation of which the securities
having a majority of the voting power in electing  directors are, at the time of
determination,   owned  by  the  Company,   directly  or  through  one  of  more
Subsidiaries.

         18. Executive Representations. Executive hereby represents and warrants
to the  Company  that  (a)  the  execution,  delivery  and  performance  of this
Agreement by Executive does not and will not conflict with,  breach,  violate or
cause a default under any contract,  agreement,  instrument,  order, judgment or
decree to which Executive is a party or by which she is bound,  and (b) upon the
execution and delivery of this Agreement by the Company, this Agreement shall be
the valid and binding  obligation of Executive,  enforceable in accordance  with
its terms.

         19. Company Representations. The Company hereby represents and warrants
to Executive that (a) the execution,  delivery and performance of this Agreement
by the Company does not and will not conflict with,  breach,  violate or cause a
default under any contract, agreement,  instrument, order, judgment or decree to
which Company is a party or by which it is bound, and (b) upon the execution and
delivery of this Agreement by Executive,  this Agreement  shall be the valid and
binding obligation of the Company, enforceable in accordance with its terms.

         20.  Severability and Modification.  If any provision of this Agreement
shall be held or declared to be illegal, invalid or unenforceable, such illegal,
invalid or unenforceable  provision shall not affect any other provision of this
Agreement,  and the remainder of this Agreement shall continue in full force and
effect as though such provision had not been contained in this Agreement. If the
scope of any  provision  in this  Agreement  is found to be too  broad to permit
enforcement of such provision to its full extent, Executive consents to judicial
modification of such provision and  enforcement to the maximum extent  permitted
by law.

         21. Notices. Except as otherwise expressly set forth in this Agreement,
all notices, requests and other communications to be given or delivered under or
by reason of the provisions of this  Agreement  shall be in writing and shall be
given (and, except as otherwise  provided in this Agreement,  shall be deemed to
have  been  duly  given if so  given)  when  delivered  if given in person or by
telegram,  three days after being mailed by first class  registered or certified
mail,  return receipt  requested,  postage prepaid,  or one day after being sent
prepaid  via  reputable  overnight  courier  to the  parties  at  the  following
addresses  (or such  other  address  as shall be  furnished  in  writing by like
notice;  provided,  however, that notice of change of address shall be effective
only upon receipt):

                                        9

<PAGE>



Notices to Executive
         Patricia A. Pilia, Ph.D.
         c/o NaPro BioTherapeutics, Inc.
         6304 Spine Road, Unit A
         Boulder, Colorado  80301

Notices to Company
         NaPro BioTherapeutics,
         6304 Spine Road, Unit A
         Boulder, Colorado 80301

         Attn.:   Gordon H. Link, Jr.
                  Vice President, Finance and
                  Chief Financial Officer

         with a copy to:
         Holme Roberts & Owen
         1700 Lincoln, Suite 4100
         Denver, CO 80203

         Attn.:  Francis Wheeler

     22. Entire Agreement.  This Agreement contains the entire agreement between
the  parties  with  respect to the  subject  matter  hereof and  supersedes  any
previous  understandings or agreements,  whether written or oral, regarding such
subject matter, including but not limited to the Prior Agreement.

     23. Governing Law. All questions concerning the construction,  validity and
interpretations  of this Agreement will be governed by the internal law, and not
the law of conflicts, of the State of Colorado.

     24.  Survival.  Paragraphs  6, 9, 10,  11,  12, 13, 14 and 16 and any other
provision of this Agreement which by its terms could survive  termination of the
Employment  Period shall survive and continue in full force in  accordance  with
their terms notwithstanding any termination of the Employment Period.

     25. Counterparts.  This Agreement may be executed in separate counterparts,
each of which is  deemed  to be an  original  and all of  which  taken  together
constitute one and the same agreement.

     26. Successors and Assigns. This Agreement is intended to bind and inure to
the benefit of and be enforceable by Executive, the Company and their respective
successors and assigns;  provided that in no event shall Executive's obligations
under this  Agreement  be  delegated  or  transferred  by  Executive,  nor shall
Executive's  rights be subject to  encumbrance  or to the claims of  Executive's
creditors.  This  Agreement  is for the sole  benefit of the parties  hereto and
shall not create any rights in third  parties other than  Executive's  spouse or
beneficiary as expressly set forth herein.

                                       10

<PAGE>



     27. Remedies.  Except as otherwise provided in this Agreement,  (i) each of
the parties to this  Agreement will be entitled to enforce its rights under this
Agreement  specifically,  to  recover  damages  by reason  of any  breach of any
provision of this  Agreement and to exercise all other rights to which it may be
entitled and (ii) disputes under this Agreement not finally  resolved in writing
by the parties  within  sixty days after one party gives notice in good faith to
the other party that a bona fide dispute  exists  shall be resolved  pursuant to
binding arbitration  conducted in Denver,  Colorado in accordance with the rules
of the  American  Arbitration  Association.  The  prevailing  party  in any such
arbitration  shall  be  entitled  to have  its  costs  and  expenses  (including
reasonable  attorney's fees and expenses)  relating to such  arbitration paid by
the other party if the  arbitrator(s)  conducting such arbitration so determine.
Notwithstanding  the  foregoing,  the parties agree and  acknowledge  that money
damages  may not be an  adequate  remedy  for breach of the  provisions  of this
Agreement  and that any party may in its sole  discretion  apply to any court of
law  or  equity  of  competent  jurisdiction  for  specific  performance  and/or
injunctive  relief  in  order  to  enforce  or  prevent  any  violations  of the
provisions of this Agreement. The prevailing party in any suit shall be entitled
to recover reasonable attorneys fees and costs from the other party.

     28.  Modifications  and  Waivers.  No provision  of this  Agreement  may be
modified,  altered or amended except by an instrument in writing executed by the
parties  hereto.  No waiver by either  party  hereto of any  breach by the other
party hereto of any term or provision of this  Agreement to be performed by such
other  party  shall  be  deemed a  waiver  of  similar  or  dissimilar  terms or
provisions at the time or at any prior or subsequent time.

     29. Headings.  The headings  contained herein are solely for the purpose of
reference,  are not part of this  Agreement  and shall not in any way affect the
meaning or interpretation of this Agreement.

     30. Notification of Subsequent Employer.  Executive agrees that the Company
may present a copy of this Agreement to any third party.

     31.  UNDERSTAND  AGREEMENT.  EXECUTIVE  REPRESENTS  AND  WARRANTS  THAT (a)
EXECUTIVE HAS READ AND UNDERSTOOD  EACH AND EVERY  PROVISION OF THIS  AGREEMENT,
(b)  EXECUTIVE  HAS HAD THE  OPPORTUNITY  TO OBTAIN ADVICE FROM LEGAL COUNSEL OF
EXECUTIVE'S  CHOICE,  OTHER THAN COUNSEL TO THE COMPANY (WHO IS NOT REPRESENTING
THE EXECUTIVE),  IN ORDER TO INTERPRET ANY AND ALL PROVISIONS OF THIS AGREEMENT,
(c) EXECUTIVE HAS HAD THE  OPPORTUNITY TO ASK THE COMPANY  QUESTIONS  ABOUT THIS
AGREEMENT  AND ANY OF SUCH  QUESTIONS  EXECUTIVE HAS ASKED HAVE BEEN ANSWERED TO
EXECUTIVE'S  SATISFACTION,  AND  (d)  EXECUTIVE  HAS  BEEN  GIVEN A COPY OF THIS
AGREEMENT.


                                       11

<PAGE>


         IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
duly executed on the day and year first above written.

                               EXECUTIVE

                                        /s/ Patricia A. Pilia
                               -----------------------------------
                                        Patricia A. Pilia


                               NAPRO BIOTHERAPEUTICS, INC.


                               By:      /s/ Gordon H. Link, Jr.
                                        Gordon H. Link, Jr.
                                        Vice President, Finance and
                                        Chief Financial Officer


                                       12

<PAGE>







                              EMPLOYMENT AGREEMENT

     THIS AGREEMENT (the  "Agreement") is entered into effective this 5th day of
October,  1998 (the  "Effective  Date"),  by and between NaPro  BioTherapeutics,
Inc.,  a  Delaware  corporation  (the  "Company"),   and  Gordon  H.  Link,  Jr.
("Executive"). Certain capitalized terms used in this Agreement have the meaning
set forth in Paragraph 17 hereof.

                                    RECITALS

         A.       WHEREAS, Executive is currently employed by the Company; and

         B. WHEREAS,  the Company  desires to secure the  continued  services of
Executive as an employee of the Company, and to provide for certain compensation
and benefit  arrangements for Executive in the event of Executive's  termination
of  employment  under certain  circumstances,  and Executive is willing to enter
into this Agreement and perform such services.

                              TERMS AND CONDITIONS

         In  consideration  of the  respective  covenants and  agreements of the
parties contained in this Agreement, the parties agree as follows:

         1. Employment Services.  The Company hereby agrees to engage Executive,
and Executive  hereby agrees to perform  services for the Company,  on the terms
and conditions  set forth in this  Agreement.  During the Employment  Period (as
defined below),  the Company and Executive agree that Executive will serve as an
executive officer of the Company in the position of Vice President,  Finance and
Chief Financial Officer with the duties,  responsibilities  and authority as set
forth on  Schedule  A, or will have such  other  executive  title and such other
executive  duties,  responsibilities  and authority as Executive and the Company
may agree upon from time to time, and will perform such services of an executive
and  administrative   character  to  the  Company  and  its  present  or  future
Subsidiaries  consistent  with  the  duties  of the  Company's  other  executive
officers,  as the  Company's  Board of Directors  (the "Board") may from time to
time  direct  (the  "Employment  Services")  or the  Bylaws of the  Company  may
provide.  The Employment Services shall commence upon the Effective Date of this
Agreement and terminate as provided in Paragraph 6 (the "Employment Period").

         2.       Performance.

                  (a) Executive shall report to the Chief Executive  Officer (or
person  acting in a  similar  capacity  if the  Company  has no Chief  Executive
Officer), and Executive shall devote his best efforts and his full business time
and  attention  (except for permitted  vacation  periods) to the business of the
Company and its Subsidiaries;  provided,  however,  that upon prior agreement by
the  Chief  Executive  Officer,  and  subject  to the  terms of this  Agreement,
Executive  may  engage  in  independent  activities  in areas  unrelated  to the
Company's business or the Company's actual or demonstrably anticipated business;
and provided,  further,  that no such  independent  activities  shall materially
detract from the  essentially  full time commitment of Executive to the business
and  affairs  of  the   Company.   Executive   shall   perform  his  duties  and
responsibilities  to the  best  of his  abilities  in a  diligent,  trustworthy,
businesslike and professional manner.


<PAGE>




                  (b)  Unless  the  Company  and  Executive   otherwise   agree,
Executive  shall  perform the  Employment  Services at the  Company's  executive
offices and traveling on business as Executive and the Company shall  reasonably
deem necessary.

         3.       Compensation.

                  (a)  During  the  Employment  Period,  the  Company  will  pay
Executive for the  Employment  Services a base salary (the "Base Salary") at the
annual  rate  of  $125,000  or such  other  increased  rate as the  compensation
committee of the Board or Board committee  performing  equivalent functions (the
"Compensation  Committee") (or if the Board has no Compensation Committee at the
time, then the Board) may designate from time to time, such salary to be paid at
such periods as salary is paid to other executive  officers of the Company.  The
Compensation  Committee  (or the Board,  if  applicable)  shall  review the Base
Salary of the Executive at least  annually on the  anniversary  of the Effective
Date and may, in its sole  discretion,  increase  (but not  decrease)  such Base
Salary  from time to time.  Payment of the Base  Salary  shall be subject to the
customary withholding tax and other employment taxes as required with respect to
compensation paid by a corporation to an employee.

                  (b) Executive  may receive an annual bonus in such amount,  if
any,  as  the  Compensation  Committee  (or  if the  Board  has no  Compensation
Committee  at the  time,  then  the  Board),  in its  discretion,  may  award to
Executive, based upon Executive's and the Company's performance during each year
of the Employment  Period,  provided,  however that each annual bonus payable to
Executive during the Employment Period shall not be less than the greater of (i)
$15,000 or (ii) the amount of the highest annual bonus paid to Executive for the
three most recent fiscal years of the Company.

                  (c) The  Executive  shall be  entitled  to receive  such stock
options  during the  Employment  Period as  determined  from time to time by the
Compensation  Committee  (or if the Board has no  Compensation  Committee at the
time, then the Board).

         4.  Reimbursement  for Expenses.  The Company shall promptly  reimburse
Executive  for all  reasonable  out-of-pocket  expenses  incurred  by him in the
course of performing his duties under this  Agreement,  subject to the Company's
reasonable  requirements  with respect to reporting  and  documentation  of such
expenses.

         5. Benefits. Executive shall be entitled to all fringe benefits offered
by the Company  and to  participate  in all of the  Company's  employee  benefit
programs both on the same basis as available to  executives of the Company,  and
shall be  entitled  to such  other  benefits  as may  from  time to time be made
available to  Executive.  The Company  shall use  commercially  reasonable  best
efforts to obtain and keep directors' and officers' liability insurance coverage
in effect in an amount equivalent to that of a well-insured,  similarly-situated
company;  provided,  however, that the failure to obtain and keep such insurance
in effect after the Company has  exercised  such  commercially  reasonable  best
efforts shall not be a breach of the Company's obligations under this Agreement.
During the Employment Period,  Executive shall be entitled to four weeks of paid
vacation during each year of the Employment Period and may carry over up to four
weeks of vacation from one year

                                        2

<PAGE>



to the next succeeding year only.

         6.       Term and Termination.

                  (a)  Except  as  otherwise  provided  in this  Agreement,  the
Employment Period shall terminate upon the earlier of:

     (i) three  years from the  Effective  Date  hereof  (the  "Initial  Term");
provided,  however,  that the  Employment  Period  shall be extended by one year
after  the  Initial  Term and each year  thereafter  on the  anniversary  of the
Effective Date of this Agreement (each such extension,  a "Renewal Term") unless
either Executive or the Board shall have given written notice to the other party
no later than 180 days prior to the  commencement  of any Renewal Term of his or
its  desire  to  terminate  the  Employment  Period  on the  date  prior  to the
commencement of such Renewal Term;

     (ii) Executive's  incapacity or permanent  disability (which in either case
shall be deemed to occur only in the event  Executive  is unable to perform  the
Employment Services for 180 days in any 12-month period) or death;

     (iii)  termination by Executive  voluntarily or for Good Reason (as defined
below);

     (iv) termination by the Company with or without Cause (as defined below).

                  (b) If the Employment  Period is terminated (i) by the Company
without  Cause or (ii) by Executive  for Good Reason,  then  Executive  shall be
entitled to receive,  so long as Executive  has not breached the  provisions  of
Paragraphs  9, 10,  12, 13,  14, or 16 hereof in a manner  that could  adversely
affect  the  Company,  his  Base  Salary  in cash at the  periods  set  forth in
Paragraph 3, at a rate equal to the then  applicable rate set forth in Paragraph
3 for a period  equal to the  greater  of (x) the  remainder  of the  Employment
Period,  but not in excess of three  years or (y) two years plus in either  case
(I) the  greater  of (A) the  most  recent  annual  bonus,  if any,  awarded  to
Executive  pursuant to  Paragraph  3(b) during the  Company's  fiscal year of or
during the Company's  fiscal year prior to termination,  as the case may be, (B)
the  average  amount  of the last  three  annual  bonuses,  if any,  awarded  to
Executive  pursuant to  Paragraph  3(b) prior to  termination,  or (C)  $20,000,
multiplied by in any case not less than the number of years for which  Executive
is entitled to receive his Base Salary pursuant to this Paragraph 6(b) (prorated
for any partial  year) (such bonus amounts to be paid pro rata over the term for
which  Executive  is  entitled  to  receive  his Base  Salary  pursuant  to this
Paragraph  6(b));  plus (II) at Executive's  election,  medical,  dental and any
other health  insurance,  life  insurance,  accidental  death and  dismemberment
insurance  and  disability  protection  no less  favorable to Executive  and his
dependents  covered thereby  (including that Executive shall remain obligated to
continue  to pay any  costs or  expenses  which  Executive  would  otherwise  be
obligated  to pay  pursuant  to such  insurance  or other  protections  provided
pursuant to Paragraph 5 as in existence on the date of such  termination)  until
the first to occur of (i) the date of Executive's  re-employment  and subsequent
opportunity  to  participate  in any health  insurance  program with  comparable
coverage provided by such new employer, including without limitation,

                                        3

<PAGE>



coverage with respect to any  pre-existing  conditions  or (ii) eighteen  months
after such termination date.

                  (c) If a Change of  Control  (as  defined  below)  occurs  and
Executive  is  thereafter  offered and  accepts  continued  employment  with the
Company (or its  successor),  and either (i) he is still employed by the Company
on the  first  calendar  anniversary  of the  Change  of  Control,  or (ii)  his
employment  with the Company is  terminated  by the Company  without Cause or he
terminates  his  employment  for Good Reason  during such one year  period,  the
Company shall pay Executive, in addition to any other amounts payable hereunder,
a "stay bonus"  equal to one year's then current Base Salary.  Such "stay bonus"
shall be paid in a cash lump sum to Executive  within twenty (20) days following
the earlier of (i) the first anniversary of the date of the Change of Control or
(ii) the date of his termination of employment with the Company. For purposes of
this  Agreement,  a  "Change  of  Control"  means  the  happening  of any of the
following:  (i) the merger or  consolidation of the Company into a new surviving
company  in  which  the  holders  of  the  Company's  voting  securities  (on  a
fully-diluted  basis)  immediately prior to the merger or consolidation own less
than a majority  of the  ordinary  voting  power to elect  directors  of the new
surviving  company  (on a fully  diluted  basis),  or (ii) when any  "person" as
defined in Section 3(a)(9) of the Securities Exchange Act of 1934 (the "34 Act")
and as used in Sections 13(d) and 14(d) thereof,  including a "group" as defined
in Section 13(d) of the 34 Act but  excluding the Company and any  Subsidiary or
any  employee  benefit  plan  sponsored  or  maintained  by the  Company  or any
Subsidiary  (including  a trustee of such plan acting as  trustee),  directly or
indirectly,  becomes the "beneficial  owner" (as defined in Rule 13d-3 under the
34 Act, as amended from time to time), of securities of the Company representing
25% or more of the  combined  voting  power of the  Company's  then  outstanding
securities.

                  (d)  Except  as  provided  in  Paragraphs  6(b) or  (c),  upon
termination of the  Employment  Period,  Executive  shall be entitled to receive
only  (i)  accrued  but  unpaid  salary  and  bonus  through  the  date  of such
termination and (ii) unpaid salary with respect to any vacation days accrued but
not taken as of the date of such termination.

                  (e) For purposes of this Agreement, "Cause" shall mean (i) the
conviction (or plea of nolo  contendere) of a felony or a crime  involving moral
turpitude or the  commission of any other act which has an adverse effect on the
Company and which involves  dishonesty,  disloyalty or fraud with respect to the
Company or any of its Subsidiaries,  (ii) conduct bringing the Company or any of
its  Subsidiaries  into  substantial  public  disgrace or disrepute,  including,
without limitation, such conduct resulting from repeated acts of alcohol or drug
abuse, (iii) continued failure by Executive to substantially  perform his duties
as reasonably  directed by the Board for a period of 15 days after the Board has
made a demand for  substantial  performance  which  specifically  identifies the
manner  in  which  the  Board  believes  that  Executive  has not  substantially
performed his duties,  or (iv) gross  negligence or misconduct not in good faith
with  respect  to the  Company  or any of its  Subsidiaries,  or (v)  any  other
material  breach  of this  Agreement  which is not cured  within  15 days  after
Executive's receipt of written notice thereof.

                  (f)  For  purposes  of  this  Agreement,  termination  of  the
Employment  Period by Executive  for "Good  Reason"  shall mean  termination  by
Executive  (i) within 90 days after  Executive  has been  assigned,  without his
consent, to any duties substantially inconsistent with his position,

                                        4

<PAGE>



duties, responsibilities or status with the Company as contemplated in Paragraph
1 of this  Agreement;  (ii)  following a Change of Control,  upon failure of the
Company to pay  Executive  an annual  bonus equal to the average  amount of such
annual  bonus paid to  Executive  during the three  fiscal  years of the Company
immediately  preceding  the year in which the  Change of Control  occurs;  (iii)
following a reduction of Executive's Base Salary after a Change of Control; (iv)
if Executive is required to regularly  perform the duties of his employment more
than 50 miles from  Boulder,  Colorado;  or (v) upon a  material  breach of this
Agreement by the Company  which is not cured within 30 days after the  Company's
receipt of written notice thereof. Executive shall provide written notice to the
Company of any and all grounds that Executive  alleges  constitute "Good Reason"
and the Company shall have 30 days after receipt of such written  notice to cure
any such alleged grounds for "Good Reason". If, following the expiration of such
30 day  period,  Executive  still  believes  that "Good  Reason"  exists for his
termination of Employment, the provisions of Paragraph 7 shall apply.

                  (g) Promptly  (but in any event within 20 days)  following any
termination  of the  Employment  Period,  and as of that date,  the Company will
notify  Executive of the itemized and  aggregate  cash value of the payments and
benefits,  as determined  under  Section 280G of the Internal  Revenue Code (the
"Code"),  received  or to be  received  by  Executive  in  connection  with  the
termination of his  employment  (whether  payable  pursuant to the terms of this
Agreement or otherwise). At the same time, the Company shall advise Executive of
the portion of such payments or benefits  which  constitute  parachute  payments
within the meaning of the Code and which may subject Executive to the payment of
excise  taxes  pursuant to Section  4999 and the  expected  amount of such taxes
(such  payments  or  benefits  being  hereinafter   referred  to  as  "Parachute
Payments").

                  (h)  Notwithstanding  the provisions of Paragraph 6(b) hereof,
if all or any portion of the payments or benefits  provided under Paragraph 6(b)
either alone or together  with other  payments or benefits  which  Executive has
received  or is  then  entitled  to  receive  from  the  Company  and any of its
Subsidiaries  would  constitute  Parachute  Payments,  such payments or benefits
provided  to  Executive  under  Paragraph  6(b)  shall be  reduced to the extent
necessary so that no portion  thereof shall be subject to the excise tax imposed
by  Section  4999 of the  Code;  but  only  if,  by  reason  of such  reduction,
Executive's net after tax benefit shall exceed the net after tax benefit if such
reduction were not made.  "Net after tax benefit" for purposes of this Paragraph
6(h)  shall mean the sum of (i) the total  amount  payable  to  Executive  under
Paragraphs 6(b) and (c) hereof,  plus (ii) all other payments and benefits which
Executive  has received or is then  entitled to receive from the Company and any
of its subsidiaries  that would constitute a Parachute  Payment,  less (iii) the
amount of federal  income taxes payable with respect to the payment and benefits
described in (i) and (ii) above  calculated at the maximum  marginal  income tax
rate  for  each  year in  which  such  payments  and  benefits  shall be paid to
Executive  (based upon the rate in effect for such year as set forth in the Code
at the  Termination  Date),  less (iv) the amount of excise  taxes  imposed with
respect to the payments and benefits  described in (i) and (ii) above by Section
4999 of the Code.

                  For purposes of this Paragraph 6(h),  Executive's base amount,
the present  value of the Parachute  Payments,  the amount of the excise tax and
all other appropriate  matters shall be determined by the Company's  independent
auditors in accordance with the principles of Section 280G of the Code and based
upon the advice of tax counsel selected by the Company,  which tax counsel shall
be reasonably satisfactory to Executive.


                                        5

<PAGE>



         7.  Notice of Certain  Terminations.  In the event that  either (i) the
Company shall  terminate  Executive for Cause or (ii) Executive  shall terminate
for Good Reason,  then any such  termination  shall be  communicated  by written
notice to the other party hereto. Any such notice shall specify(x) the effective
date of  termination  of the  Employment  Period,  which,  except  as  otherwise
provided in  Paragraph  6(f),  shall not be more than 30 days after the date the
notice is delivered  (the  "Termination  Effective  Date" and (y) in  reasonable
detail  the  facts  and  circumstances   underlying  a  determination  that  the
termination  is for Cause or for Good  Reason,  as the case may be. If within 15
days after any notice of  termination  of Executive  for Cause by the Company is
given,  or if  within 15 days  after  the  Company's  30 day cure  period  under
Paragraph 6(f) has expired,  the party  receiving such notice notifies the other
party that a good faith dispute exists  concerning the  characterization  of the
termination,  the  Termination  Effective  Date  shall be the date on which such
dispute is finally  resolved  either by written  agreement  of the parties or by
binding arbitration  conducted pursuant to the rules of the American Arbitration
Association. Notwithstanding the pendency of any such dispute, the Company shall
continue Executive and his dependents as participants in all medical, dental and
any other health  insurance and similar benefit plans of the Company in which he
and they were  participating  when the notice  giving  rise to the  dispute  was
given,  until the  dispute is finally  resolved.  Benefits  provided  under this
Paragraph 7 are in addition to all other  amounts due under this  Agreement  and
shall not be  offset  against,  or reduce  any other  amounts  due  under,  this
Agreement.

         8.  Insurance.  The Company  may, at its  election and for its benefit,
insure Executive  against  accidental  death, and Executive shall submit to such
physical  examination  and  supply  such  information  as  may  be  required  in
connection therewith.

         9.       Non-disclosure of Confidential Information.

                  (a) Unless  Executive  first secures  written consent from the
Company  pursuant to  procedures  implemented  by Company after the date hereof,
Executive  shall not disclose or use at any time,  either during the  Employment
Period or thereafter,  any Confidential Information (as defined in Paragraph 17)
except to the extent Executive  reasonably  believes is necessary to disclose or
use  such  Confidential  Information  in  performing  the  Employment  Services.
Executive  further agrees that Executive will use  Executive's  commercial  best
efforts  to  safeguard  the  Confidential  Information  and  protect  it against
disclosure,  misuse, espionage,  loss and theft, including,  without limitation,
causing  recipients of  Confidential  Information  to enter into  non-disclosure
agreements with the Company.  Subject to the provisions of Paragraphs 10 and 13,
nothing herein shall be construed to prevent  Executive  from using  Executive's
general  knowledge  and  skill  after  termination  of this  Agreement,  whether
Executive  acquired  such  knowledge  or skill  before or during the  Employment
Period.

                  (b) In the event the Company has entered into  confidentiality
agreements with third parties (not including  Company  employees)  which contain
provisions  different from those set forth in this Agreement,  Executive agrees,
in  addition  to the  provisions  of  Paragraph  9(a),  to comply  with any such
different provisions of which Executive is notified by the Company.

         10.  Company  Ownership  of  Intellectual  Property.  Executive  hereby
assigns to the Company all right,  title and interest in and to all Intellectual
Property (as defined in  Paragraph  17)  contributed  to or conceived or made by
Executive during the Employment Period and prior to the

                                        6

<PAGE>



Employment  Period  during the period  Executive  was  employed by or engaged in
research or development  activities for or with the Company or its  predecessors
and  affiliates  (whether  alone or jointly  with  others)  to the  extent  such
Intellectual  Property is not owned by the Company as a matter of law. Executive
shall promptly and fully  communicate to the Company all  Intellectual  Property
conceived,  contributed  to or made by Executive  and shall  cooperate  with the
Company  to  protect  the  Company's  interests  in such  Intellectual  Property
including,   without  limitation,   providing   assistance  in  securing  patent
protection  and copyright  registrations  and signing all  documents  reasonably
requested by the  Company,  even if such  request  occurs  after the  Employment
Period.  The Company shall pay  Executive's  reasonable  expenses of cooperating
with the Company in  protecting  the  Company's  interests in such  Intellectual
Property  unless the subject  matter of the requested  cooperation is related to
actions taken or failed to be taken by Executive  wrongfully or otherwise not in
good faith.

         11. Executive's  Rights.  Paragraph 10 of this Agreement does not apply
to an invention  for which no  equipment,  supplies,  facilities or trade secret
information  of the  Company  was used  and  which  was  developed  entirely  on
Executive's  own time,  unless (a) the invention  relates (i) to the business of
the  Company,  or (ii)  to the  Company's  actual  or  demonstrably  anticipated
material  research or  development,  or (b) the invention  results from any work
performed by Executive for the Company.

         12. Return of Materials.  Upon termination of the Employment Period, or
at any time  reasonably  requested  by the  Company,  Executive  shall  promptly
deliver to the Company all copies of  Confidential  Information  in  Executive's
possession  and control,  including  written  records,  manuals,  lab notebooks,
customer and supplier lists and all other materials  containing any Confidential
Information.   If  the  Company   requests,   Executive  shall  provide  written
confirmation  that  Executive  has returned all such  materials.  Subject to the
provisions  of this  Agreement,  including,  without  limitation,  Paragraph 11,
notwithstanding  anything in this Agreement to the contrary, upon termination of
the  Employment  Period,  the Company,  at Executive's  request,  shall promptly
return to Executive any  equipment or other  materials  owned by Executive  then
being used by or then in the possession of the Company.

         13. Non-Competition.  Executive acknowledges and agrees that during the
Employment  Period and for a period of five years  thereafter (the  "Non-compete
Period"),  Executive will not, without the prior written consent of the Company,
directly or indirectly,  provide products or services  substantially  similar to
the  Employment  Services to any  business or entity that  provides or offers or
demonstrably  plans to provide or offer,  products or services  that (i) are the
same as or  substantially  similar to the  products or services  provided by the
Company at any time during the Employment  Period,  (ii) relate to the Company's
Intellectual  Property (whether the Company acquired such Intellectual  Property
pursuant to this Agreement or otherwise),  or (iii) relate to any subject matter
of the  Company's  actual or  demonstrably  anticipated  material  research  and
development during the Employment Period,  including without limitation,  taxol,
taxanes  and any other  compounds,  within  any  geographical  area in which the
Company or any of its  subsidiaries  provide or plan to provide such products or
services.
         14. Non-Solicitation. Executive acknowledges and agrees that during the
Non-compete Period Executive will not (a) solicit,  induce or attempt to induce,
directly or  indirectly,  any employee of the Company to leave the employment of
the Company to work for Executive or for any other

                                        7

<PAGE>



person, firm or corporation or (b) hire any employee of the Company.

         15. Acknowledgment of Reasonableness. Executive acknowledges and agrees
that the  limitations  set forth in  Paragraphs  13 and 14 are  reasonable  with
respect to scope, duration and geographic area and are properly required for the
protection of the legitimate business interest of the Company.

         16. Further Assistance.  During the Non-compete Period,  Executive will
not make any disclosure or other  communication to any person,  issue any public
statements or otherwise cause to be disclosed any information which is designed,
intended or might reasonably be anticipated to discourage any persons from doing
business with the Company or otherwise have a negative  impact or adverse effect
on the Company,  except to the extent such disclosure is required by law. During
the Non-compete Period,  Executive will provide assistance  reasonably requested
by the  Company  in  connection  with  actions  taken by  Executive  during  the
Employment  Period,  including but not limited to assistance in connection  with
any lawsuits or other claims against the Company  arising from events during the
Employment  Period,  provided  that the Company shall  reimburse all  reasonable
expenses  (including  without  limitation,  reasonable loss of compensation from
other sources resulting from such assistance during normal business hours).

         17.      Certain Definitions.

                  "Affiliate"  means  a  person  that  directly,  or  indirectly
through one or more intermediaries,  controls,  or is controlled by, or is under
common control with, the person specified.

                  "Confidential  Information" means all information  (whether or
not specifically labeled or identified as confidential),  in any form or medium,
that is disclosed to, or developed or learned by Executive during the Employment
Period  and prior to the  Employment  Period  during the  period  Executive  was
employed  by or engaged in research or  development  activities  for or with the
Company or its  predecessors  and  affiliates  or that relates to the  business,
products,  services,  customers,  research or  development  of the Company,  its
Subsidiaries,  its  Affiliates,  or third  parties  with whom the  Company,  its
Subsidiaries  or its  Affiliates  does  business or from whom the Company or its
Affiliates receives information.  Confidential Information shall not include any
information that (i) has become publicly known through no wrongful act or breach
of any  obligation  of  confidentiality,  as  evidenced  by  written  records or
documents;  or (ii) was rightfully  received by Executive on a  non-confidential
basis  from a third  party  (provided  that  such  third  party is not  known to
Executive to be bound by a confidentiality agreement with the Company or another
party), as evidenced by written records or documents.

                  "Independent  Third  Party"  means  any  person,  including  a
"group" as defined in Section  13(d)(3) of the Securities  Exchange Act of 1934,
as amended, and the rules and regulations thereunder,  who, immediately prior to
the  contemplated  transaction,  does not own in excess  of 5% of the  Company's
Common Stock on a fully-diluted basis, who is not controlling,  controlled by or
under common  control with any such 5% owner of the  Company's  Common Stock and
who is not the spouse or descendent  (by birth or adoption) of any such 5% owner
of the Company's Common Stock.


                                        8

<PAGE>



                  "Intellectual  Property"  means any idea,  invention,  design,
development,  device, method or process (whether or not patentable or reduced to
practice or  including  Confidential  Information)  and all related  patents and
patent  applications,  any  copyrightable  work or  mask  work  (whether  or not
including   Confidential   Information)  and  all  related   registrations   and
applications for registration, and all other proprietary rights.

                  "Subsidiaries"  means any  corporation of which the securities
having a majority of the voting power in electing  directors are, at the time of
determination,   owned  by  the  Company,   directly  or  through  one  of  more
Subsidiaries.

         18. Executive Representations. Executive hereby represents and warrants
to the  Company  that  (a)  the  execution,  delivery  and  performance  of this
Agreement by Executive does not and will not conflict with,  breach,  violate or
cause a default under any contract,  agreement,  instrument,  order, judgment or
decree to which  Executive is a party or by which he is bound,  and (b) upon the
execution and delivery of this Agreement by the Company, this Agreement shall be
the valid and binding  obligation of Executive,  enforceable in accordance  with
its terms.

         19. Company Representations. The Company hereby represents and warrants
to Executive that (a) the execution,  delivery and performance of this Agreement
by the Company does not and will not conflict with,  breach,  violate or cause a
default under any contract, agreement,  instrument, order, judgment or decree to
which Company is a party or by which it is bound, and (b) upon the execution and
delivery of this Agreement by Executive,  this Agreement  shall be the valid and
binding obligation of the Company, enforceable in accordance with its terms.

         20.  Severability and Modification.  If any provision of this Agreement
shall be held or declared to be illegal, invalid or unenforceable, such illegal,
invalid or unenforceable  provision shall not affect any other provision of this
Agreement,  and the remainder of this Agreement shall continue in full force and
effect as though such provision had not been contained in this Agreement. If the
scope of any  provision  in this  Agreement  is found to be too  broad to permit
enforcement of such provision to its full extent, Executive consents to judicial
modification of such provision and  enforcement to the maximum extent  permitted
by law.

         21. Notices. Except as otherwise expressly set forth in this Agreement,
all notices, requests and other communications to be given or delivered under or
by reason of the provisions of this  Agreement  shall be in writing and shall be
given (and, except as otherwise  provided in this Agreement,  shall be deemed to
have  been  duly  given if so  given)  when  delivered  if given in person or by
telegram,  three days after being mailed by first class  registered or certified
mail,  return receipt  requested,  postage prepaid,  or one day after being sent
prepaid  via  reputable  overnight  courier  to the  parties  at  the  following
addresses  (or such  other  address  as shall be  furnished  in  writing by like
notice;  provided,  however, that notice of change of address shall be effective
only upon receipt):


                                        9

<PAGE>



Notices to Executive
         Gordon H. Link, Jr.
         c/o NaPro BioTherapeutics, Inc.
         6304 Spine Road, Unit A
         Boulder, Colorado  80301

Notices to Company
         NaPro BioTherapeutics,
         6304 Spine Road, Unit A
         Boulder, Colorado 80301

         Attn.:   Patricia A. Pilia, Ph.D.
                  Executive Vice President

         with a copy to:
         Holme Roberts & Owen
         1700 Lincoln, Suite 4100
         Denver, CO 80203

         Attn.:  Francis Wheeler

     22. Entire Agreement.  This Agreement contains the entire agreement between
the  parties  with  respect to the  subject  matter  hereof and  supersedes  any
previous  understandings or agreements,  whether written or oral, regarding such
subject matter.

     23. Governing Law. All questions concerning the construction,  validity and
interpretations  of this Agreement will be governed by the internal law, and not
the law of conflicts, of the State of Colorado.

     24.  Survival.  Paragraphs  6, 9, 10,  11,  12, 13, 14 and 16 and any other
provision of this Agreement which by its terms could survive  termination of the
Employment  Period shall survive and continue in full force in  accordance  with
their terms notwithstanding any termination of the Employment Period.

     25. Counterparts.  This Agreement may be executed in separate counterparts,
each of which is  deemed  to be an  original  and all of  which  taken  together
constitute one and the same agreement.

     26. Successors and Assigns. This Agreement is intended to bind and inure to
the benefit of and be enforceable by Executive, the Company and their respective
successors and assigns;  provided that in no event shall Executive's obligations
under this  Agreement  be  delegated  or  transferred  by  Executive,  nor shall
Executive's  rights be subject to  encumbrance  or to the claims of  Executive's
creditors.  This  Agreement  is for the sole  benefit of the parties  hereto and
shall not create any rights in third  parties other than  Executive's  spouse or
beneficiary as expressly set forth herein.


                                       10

<PAGE>



     27. Remedies.  Except as otherwise provided in this Agreement,  (i) each of
the parties to this  Agreement will be entitled to enforce its rights under this
Agreement  specifically,  to  recover  damages  by reason  of any  breach of any
provision of this  Agreement and to exercise all other rights to which it may be
entitled and (ii) disputes under this Agreement not finally  resolved in writing
by the parties  within  sixty days after one party gives notice in good faith to
the other party that a bona fide dispute  exists  shall be resolved  pursuant to
binding arbitration  conducted in Denver,  Colorado in accordance with the rules
of the  American  Arbitration  Association.  The  prevailing  party  in any such
arbitration  shall  be  entitled  to have  its  costs  and  expenses  (including
reasonable  attorney's fees and expenses)  relating to such  arbitration paid by
the other party if the  arbitrator(s)  conducting such arbitration so determine.
Notwithstanding  the  foregoing,  the parties agree and  acknowledge  that money
damages  may not be an  adequate  remedy  for breach of the  provisions  of this
Agreement  and that any party may in its sole  discretion  apply to any court of
law  or  equity  of  competent  jurisdiction  for  specific  performance  and/or
injunctive  relief  in  order  to  enforce  or  prevent  any  violations  of the
provisions of this Agreement. The prevailing party in any suit shall be entitled
to recover reasonable attorneys fees and costs from the other party.

     28.  Modifications  and  Waivers.  No provision  of this  Agreement  may be
modified,  altered or amended except by an instrument in writing executed by the
parties  hereto.  No waiver by either  party  hereto of any  breach by the other
party hereto of any term or provision of this  Agreement to be performed by such
other  party  shall  be  deemed a  waiver  of  similar  or  dissimilar  terms or
provisions at the time or at any prior or subsequent time.

     29. Headings.  The headings  contained herein are solely for the purpose of
reference,  are not part of this  Agreement  and shall not in any way affect the
meaning or interpretation of this Agreement.

     30. Notification of Subsequent Employer.  Executive agrees that the Company
may present a copy of this Agreement to any third party.

     31.  UNDERSTAND  AGREEMENT.  EXECUTIVE  REPRESENTS  AND  WARRANTS  THAT (a)
EXECUTIVE HAS READ AND UNDERSTOOD  EACH AND EVERY  PROVISION OF THIS  AGREEMENT,
(b)  EXECUTIVE  HAS HAD THE  OPPORTUNITY  TO OBTAIN ADVICE FROM LEGAL COUNSEL OF
EXECUTIVE'S  CHOICE,  OTHER THAN COUNSEL TO THE COMPANY (WHO IS NOT REPRESENTING
THE EXECUTIVE),  IN ORDER TO INTERPRET ANY AND ALL PROVISIONS OF THIS AGREEMENT,
(c) EXECUTIVE HAS HAD THE  OPPORTUNITY TO ASK THE COMPANY  QUESTIONS  ABOUT THIS
AGREEMENT  AND ANY OF SUCH  QUESTIONS  EXECUTIVE HAS ASKED HAVE BEEN ANSWERED TO
EXECUTIVE'S  SATISFACTION,  AND  (d)  EXECUTIVE  HAS  BEEN  GIVEN A COPY OF THIS
AGREEMENT.


                                       11

<PAGE>


         IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
duly executed on the day and year first above written.

                            EXECUTIVE

                                     /s/ Gordon H. Link, Jr.
                            -----------------------------------
                                     Gordon H. Link, Jr.


                            NAPRO BIOTHERAPEUTICS, INC.


                            By:      /s/ Patricia A. Pilia, Ph.D.
                                     Patricia A. Pilia, Ph.D.
                                     Executive Vice President



                                       12

<PAGE>



                              EMPLOYMENT AGREEMENT

         THIS AGREEMENT (the "Agreement") is entered into effective this 5th day
of October,  1998 (the "Effective Date"), by and between NaPro  BioTherapeutics,
Inc., a Delaware corporation (the "Company"),  and David L. Denny ("Executive").
Certain  capitalized  terms used in this Agreement have the meaning set forth in
Paragraph 17 hereof.

                                    RECITALS

         A.       WHEREAS, Executive is currently employed by the Company; and

         B. WHEREAS,  the Company  desires to secure the  continued  services of
Executive as an employee of the Company, and to provide for certain compensation
and benefit  arrangements for Executive in the event of Executive's  termination
of  employment  under certain  circumstances,  and Executive is willing to enter
into this Agreement and perform such services.

                              TERMS AND CONDITIONS

         In  consideration  of the  respective  covenants and  agreements of the
parties contained in this Agreement, the parties agree as follows:

         1. Employment Services.  The Company hereby agrees to engage Executive,
and Executive  hereby agrees to perform  services for the Company,  on the terms
and conditions  set forth in this  Agreement.  During the Employment  Period (as
defined below),  the Company and Executive agree that Executive will serve as an
executive  officer of the Company in the position of Vice President,  Operations
with the duties,  responsibilities  and authority as set forth on Schedule A, or
will  have  such  other  executive  title  and  such  other  executive   duties,
responsibilities  and authority as Executive and the Company may agree upon from
time to time, and will perform such services of an executive and  administrative
character to the Company and its present or future Subsidiaries  consistent with
the duties of the Company's other executive officers,  as the Company's Board of
Directors (the "Board") may from time to time direct (the "Employment Services")
or the Bylaws of the Company may provide. The Employment Services shall commence
upon the Effective Date of this Agreement and terminate as provided in Paragraph
6 (the "Employment Period").

         2.       Performance.

                  (a) Executive shall report to the Executive Vice President (or
person  acting  in a similar  capacity  if the  Company  has no  Executive  Vice
President),  and  Executive  shall devote his best efforts and his full business
time and attention  (except for permitted  vacation  periods) to the business of
the Company and its Subsidiaries;  provided,  however, that upon prior agreement
by the Executive  Vice  President,  and subject to the terms of this  Agreement,
Executive  may  engage  in  independent  activities  in areas  unrelated  to the
Company's business or the Company's actual or demonstrably anticipated business;
and provided,  further,  that no such  independent  activities  shall materially
detract from the  essentially  full time commitment of Executive to the business
and  affairs  of  the   Company.   Executive   shall   perform  his  duties  and
responsibilities  to the  best  of his  abilities  in a  diligent,  trustworthy,
businesslike and professional manner.



<PAGE>



                  (b)  Unless  the  Company  and  Executive   otherwise   agree,
Executive  shall  perform the  Employment  Services at the  Company's  executive
offices and traveling on business as Executive and the Company shall  reasonably
deem necessary.

         3.       Compensation.

                  (a)  During  the  Employment  Period,  the  Company  will  pay
Executive for the  Employment  Services a base salary (the "Base Salary") at the
annual  rate  of  $106,000  or such  other  increased  rate as the  compensation
committee of the Board or Board committee  performing  equivalent functions (the
"Compensation  Committee") (or if the Board has no Compensation Committee at the
time, then the Board) may designate from time to time, such salary to be paid at
such periods as salary is paid to other executive  officers of the Company.  The
Compensation  Committee  (or the Board,  if  applicable)  shall  review the Base
Salary of the Executive at least  annually on the  anniversary  of the Effective
Date and may, in its sole  discretion,  increase  (but not  decrease)  such Base
Salary  from time to time.  Payment of the Base  Salary  shall be subject to the
customary withholding tax and other employment taxes as required with respect to
compensation paid by a corporation to an employee.

                  (b) Executive  may receive an annual bonus in such amount,  if
any,  as  the  Compensation  Committee  (or  if the  Board  has no  Compensation
Committee  at the  time,  then  the  Board),  in its  discretion,  may  award to
Executive, based upon Executive's and the Company's performance during each year
of the Employment  Period,  provided,  however that each annual bonus payable to
Executive during the Employment Period shall not be less than the greater of (i)
$15,000 or (ii) the amount of the highest annual bonus paid to Executive for the
three most recent fiscal years of the Company.

                  (c) The  Executive  shall be  entitled  to receive  such stock
options  during the  Employment  Period as  determined  from time to time by the
Compensation  Committee  (or if the Board has no  Compensation  Committee at the
time, then the Board).

         4.  Reimbursement  for Expenses.  The Company shall promptly  reimburse
Executive  for all  reasonable  out-of-pocket  expenses  incurred  by him in the
course of performing his duties under this  Agreement,  subject to the Company's
reasonable  requirements  with respect to reporting  and  documentation  of such
expenses.

         5. Benefits. Executive shall be entitled to all fringe benefits offered
by the Company  and to  participate  in all of the  Company's  employee  benefit
programs both on the same basis as available to  executives of the Company,  and
shall be  entitled  to such  other  benefits  as may  from  time to time be made
available to  Executive.  The Company  shall use  commercially  reasonable  best
efforts to obtain and keep directors' and officers' liability insurance coverage
in effect in an amount equivalent to that of a well-insured,  similarly-situated
company;  provided,  however, that the failure to obtain and keep such insurance
in effect after the Company has  exercised  such  commercially  reasonable  best
efforts shall not be a breach of the Company's obligations under this Agreement.
During the Employment Period,  Executive shall be entitled to four weeks of paid
vacation during each year of the Employment Period and may carry over up to four
weeks of vacation from one year to the next succeeding year only.

                                        2

<PAGE>



         6.       Term and Termination.

                  (a)  Except  as  otherwise  provided  in this  Agreement,  the
Employment Period shall terminate upon the earlier of:

     (i) three  years from the  Effective  Date  hereof  (the  "Initial  Term");
provided,  however,  that the  Employment  Period  shall be extended by one year
after  the  Initial  Term and each year  thereafter  on the  anniversary  of the
Effective Date of this Agreement (each such extension,  a "Renewal Term") unless
either Executive or the Board shall have given written notice to the other party
no later than 180 days prior to the  commencement  of any Renewal Term of his or
its  desire  to  terminate  the  Employment  Period  on the  date  prior  to the
commencement of such Renewal Term;

     (ii) Executive's  incapacity or permanent  disability (which in either case
shall be deemed to occur only in the event  Executive  is unable to perform  the
Employment Services for 180 days in any 12-month period) or death;

     (iii)  termination by Executive  voluntarily or for Good Reason (as defined
below);

     (iv) termination by the Company with or without Cause (as defined below).

                  (b) If the Employment  Period is terminated (i) by the Company
without  Cause or (ii) by Executive  for Good Reason,  then  Executive  shall be
entitled to receive,  so long as Executive  has not breached the  provisions  of
Paragraphs  9, 10,  12, 13,  14, or 16 hereof in a manner  that could  adversely
affect  the  Company,  his  Base  Salary  in cash at the  periods  set  forth in
Paragraph 3, at a rate equal to the then  applicable rate set forth in Paragraph
3 for a period equal to the greater of (x) the  remainder of the Initial Term or
the then current  Renewal  Term, as  applicable,  or (y) one year plus in either
case (I) the greater of (A) the most recent  annual  bonus,  if any,  awarded to
Executive  pursuant to  Paragraph  3(b) during the  Company's  fiscal year of or
during the Company's  fiscal year prior to termination,  as the case may be, (B)
the  average  amount  of the last  three  annual  bonuses,  if any,  awarded  to
Executive  pursuant to  Paragraph  3(b) prior to  termination,  or (C)  $15,000,
multiplied by in any case not less than the number of years for which  Executive
is entitled to receive his Base Salary pursuant to this Paragraph 6(b) (prorated
for any partial  year) (such bonus amounts to be paid pro rata over the term for
which  Executive  is  entitled  to  receive  his Base  Salary  pursuant  to this
Paragraph  6(b));  plus (II) at Executive's  election,  medical,  dental and any
other health  insurance,  life  insurance,  accidental  death and  dismemberment
insurance  and  disability  protection  no less  favorable to Executive  and his
dependents  covered thereby  (including that Executive shall remain obligated to
continue  to pay any  costs or  expenses  which  Executive  would  otherwise  be
obligated  to pay  pursuant  to such  insurance  or other  protections  provided
pursuant to Paragraph 5 as in existence on the date of such  termination)  until
the first to occur of (i) the date of Executive's  re-employment  and subsequent
opportunity  to  participate  in any health  insurance  program with  comparable
coverage provided by such new employer,  including without limitation,  coverage
with respect to any  pre-existing  conditions or (ii) eighteen months after such
termination date.

                                        3

<PAGE>



                  (c) If a Change of  Control  (as  defined  below)  occurs  and
Executive  is  thereafter  offered and  accepts  continued  employment  with the
Company (or its  successor),  and either (i) he is still employed by the Company
on the  first  calendar  anniversary  of the  Change  of  Control,  or (ii)  his
employment  with the Company is  terminated  by the Company  without Cause or he
terminates  his  employment  for Good Reason  during such one year  period,  the
Company shall pay Executive, in addition to any other amounts payable hereunder,
a "stay bonus"  equal to one year's then current Base Salary.  Such "stay bonus"
shall be paid in a cash lump sum to Executive  within twenty (20) days following
the earlier of (i) the first anniversary of the date of the Change of Control or
(ii) the date of his termination of employment with the Company. For purposes of
this  Agreement,  a  "Change  of  Control"  means  the  happening  of any of the
following:  (i) the merger or  consolidation of the Company into a new surviving
company  in  which  the  holders  of  the  Company's  voting  securities  (on  a
fully-diluted  basis)  immediately prior to the merger or consolidation own less
than a majority  of the  ordinary  voting  power to elect  directors  of the new
surviving  company  (on a fully  diluted  basis),  or (ii) when any  "person" as
defined in Section 3(a)(9) of the Securities Exchange Act of 1934 (the "34 Act")
and as used in Sections 13(d) and 14(d) thereof,  including a "group" as defined
in Section 13(d) of the 34 Act but  excluding the Company and any  Subsidiary or
any  employee  benefit  plan  sponsored  or  maintained  by the  Company  or any
Subsidiary  (including  a trustee of such plan acting as  trustee),  directly or
indirectly,  becomes the "beneficial  owner" (as defined in Rule 13d-3 under the
34 Act, as amended from time to time), of securities of the Company representing
25% or more of the  combined  voting  power of the  Company's  then  outstanding
securities.

                  (d)  Except  as  provided  in  Paragraphs  6(b) or  (c),  upon
termination of the  Employment  Period,  Executive  shall be entitled to receive
only  (i)  accrued  but  unpaid  salary  and  bonus  through  the  date  of such
termination and (ii) unpaid salary with respect to any vacation days accrued but
not taken as of the date of such termination.

                  (e) For purposes of this Agreement, "Cause" shall mean (i) the
conviction (or plea of nolo  contendere) of a felony or a crime  involving moral
turpitude or the  commission of any other act which has an adverse effect on the
Company and which involves  dishonesty,  disloyalty or fraud with respect to the
Company or any of its Subsidiaries,  (ii) conduct bringing the Company or any of
its  Subsidiaries  into  substantial  public  disgrace or disrepute,  including,
without limitation, such conduct resulting from repeated acts of alcohol or drug
abuse, (iii) continued failure by Executive to substantially  perform his duties
as reasonably  directed by the Board for a period of 15 days after the Board has
made a demand for  substantial  performance  which  specifically  identifies the
manner  in  which  the  Board  believes  that  Executive  has not  substantially
performed his duties,  or (iv) gross  negligence or misconduct not in good faith
with  respect  to the  Company  or any of its  Subsidiaries,  or (v)  any  other
material  breach  of this  Agreement  which is not cured  within  15 days  after
Executive's receipt of written notice thereof.

                  (f)  For  purposes  of  this  Agreement,  termination  of  the
Employment  Period by Executive  for "Good  Reason"  shall mean  termination  by
Executive  (i) within 90 days after  Executive  has been  assigned,  without his
consent,  to any duties  substantially  inconsistent with his position,  duties,
responsibilities  or status with the Company as  contemplated  in Paragraph 1 of
this Agreement;  (ii) following a Change of Control, upon failure of the Company
to pay  Executive  an annual  bonus equal to the  average  amount of such annual
bonus paid to Executive during the three

                                        4

<PAGE>



fiscal years of the Company  immediately  preceding the year in which the Change
of Control occurs;  (iii) following a reduction of Executive's Base Salary after
a Change of Control;  (iv) if  Executive  is required to  regularly  perform the
duties of his employment more than 50 miles from Boulder,  Colorado; or (v) upon
a material  breach of this Agreement by the Company which is not cured within 30
days after the Company's  receipt of written  notice  thereof.  Executive  shall
provide  written  notice to the  Company of any and all grounds  that  Executive
alleges  constitute  "Good  Reason"  and the  Company  shall  have 30 days after
receipt  of such  written  notice  to cure any such  alleged  grounds  for "Good
Reason".  If,  following the expiration of such 30 day period,  Executive  still
believes  that "Good  Reason"  exists for his  termination  of  Employment,  the
provisions of Paragraph 7 shall apply.

                  (g) Promptly  (but in any event within 20 days)  following any
termination  of the  Employment  Period,  and as of that date,  the Company will
notify  Executive of the itemized and  aggregate  cash value of the payments and
benefits,  as determined  under  Section 280G of the Internal  Revenue Code (the
"Code"),  received  or to be  received  by  Executive  in  connection  with  the
termination of his  employment  (whether  payable  pursuant to the terms of this
Agreement or otherwise). At the same time, the Company shall advise Executive of
the portion of such payments or benefits  which  constitute  parachute  payments
within the meaning of the Code and which may subject Executive to the payment of
excise  taxes  pursuant to Section  4999 and the  expected  amount of such taxes
(such  payments  or  benefits  being  hereinafter   referred  to  as  "Parachute
Payments").

                  (h)  Notwithstanding  the provisions of Paragraph 6(b) hereof,
if all or any portion of the payments or benefits  provided under Paragraph 6(b)
either alone or together  with other  payments or benefits  which  Executive has
received  or is  then  entitled  to  receive  from  the  Company  and any of its
Subsidiaries  would  constitute  Parachute  Payments,  such payments or benefits
provided  to  Executive  under  Paragraph  6(b)  shall be  reduced to the extent
necessary so that no portion  thereof shall be subject to the excise tax imposed
by  Section  4999 of the  Code;  but  only  if,  by  reason  of such  reduction,
Executive's net after tax benefit shall exceed the net after tax benefit if such
reduction were not made.  "Net after tax benefit" for purposes of this Paragraph
6(h)  shall mean the sum of (i) the total  amount  payable  to  Executive  under
Paragraphs 6(b) and (c) hereof,  plus (ii) all other payments and benefits which
Executive  has received or is then  entitled to receive from the Company and any
of its subsidiaries  that would constitute a Parachute  Payment,  less (iii) the
amount of federal  income taxes payable with respect to the payment and benefits
described in (i) and (ii) above  calculated at the maximum  marginal  income tax
rate  for  each  year in  which  such  payments  and  benefits  shall be paid to
Executive  (based upon the rate in effect for such year as set forth in the Code
at the  Termination  Date),  less (iv) the amount of excise  taxes  imposed with
respect to the payments and benefits  described in (i) and (ii) above by Section
4999 of the Code.

                  For purposes of this Paragraph 6(h),  Executive's base amount,
the present  value of the Parachute  Payments,  the amount of the excise tax and
all other appropriate  matters shall be determined by the Company's  independent
auditors in accordance with the principles of Section 280G of the Code and based
upon the advice of tax counsel selected by the Company,  which tax counsel shall
be reasonably satisfactory to Executive.

         7.  Notice of Certain  Terminations.  In the event that  either (i) the
Company shall  terminate  Executive for Cause or (ii) Executive  shall terminate
for Good Reason,  then any such  termination  shall be  communicated  by written
notice to the other party hereto. Any such notice shall

                                        5

<PAGE>



specify(x) the effective date of  termination of the Employment  Period,  which,
except as otherwise  provided in Paragraph 6(f),  shall not be more than 30 days
after the date the notice is delivered (the "Termination Effective Date" and (y)
in reasonable detail the facts and circumstances underlying a determination that
the  termination is for Cause or for Good Reason,  as the case may be. If within
15 days after any notice of termination of Executive for Cause by the Company is
given,  or if  within 15 days  after  the  Company's  30 day cure  period  under
Paragraph 6(f) has expired,  the party  receiving such notice notifies the other
party that a good faith dispute exists  concerning the  characterization  of the
termination,  the  Termination  Effective  Date  shall be the date on which such
dispute is finally  resolved  either by written  agreement  of the parties or by
binding arbitration  conducted pursuant to the rules of the American Arbitration
Association. Notwithstanding the pendency of any such dispute, the Company shall
continue Executive and his dependents as participants in all medical, dental and
any other health  insurance and similar benefit plans of the Company in which he
and they were  participating  when the notice  giving  rise to the  dispute  was
given,  until the  dispute is finally  resolved.  Benefits  provided  under this
Paragraph 7 are in addition to all other  amounts due under this  Agreement  and
shall not be  offset  against,  or reduce  any other  amounts  due  under,  this
Agreement.

         8.  Insurance.  The Company  may, at its  election and for its benefit,
insure Executive  against  accidental  death, and Executive shall submit to such
physical  examination  and  supply  such  information  as  may  be  required  in
connection therewith.

         9.       Non-disclosure of Confidential Information.

                  (a) Unless  Executive  first secures  written consent from the
Company  pursuant to  procedures  implemented  by Company after the date hereof,
Executive  shall not disclose or use at any time,  either during the  Employment
Period or thereafter,  any Confidential Information (as defined in Paragraph 17)
except to the extent Executive  reasonably  believes is necessary to disclose or
use  such  Confidential  Information  in  performing  the  Employment  Services.
Executive  further agrees that Executive will use  Executive's  commercial  best
efforts  to  safeguard  the  Confidential  Information  and  protect  it against
disclosure,  misuse, espionage,  loss and theft, including,  without limitation,
causing  recipients of  Confidential  Information  to enter into  non-disclosure
agreements with the Company.  Subject to the provisions of Paragraphs 10 and 13,
nothing herein shall be construed to prevent  Executive  from using  Executive's
general  knowledge  and  skill  after  termination  of this  Agreement,  whether
Executive  acquired  such  knowledge  or skill  before or during the  Employment
Period.

                  (b) In the event the Company has entered into  confidentiality
agreements with third parties (not including  Company  employees)  which contain
provisions  different from those set forth in this Agreement,  Executive agrees,
in  addition  to the  provisions  of  Paragraph  9(a),  to comply  with any such
different provisions of which Executive is notified by the Company.

         10.  Company  Ownership  of  Intellectual  Property.  Executive  hereby
assigns to the Company all right,  title and interest in and to all Intellectual
Property (as defined in  Paragraph  17)  contributed  to or conceived or made by
Executive during the Employment Period and prior to the Employment Period during
the period  Executive  was  employed by or engaged in  research  or  development
activities for or with the Company or its predecessors  and affiliates  (whether
alone or jointly  with others) to the extent such  Intellectual  Property is not
owned by the Company as a matter

                                        6

<PAGE>



of law.  Executive  shall  promptly  and fully  communicate  to the  Company all
Intellectual  Property conceived,  contributed to or made by Executive and shall
cooperate  with  the  Company  to  protect  the  Company's   interests  in  such
Intellectual  Property including,  without limitation,  providing  assistance in
securing patent protection and copyright registrations and signing all documents
reasonably  requested  by the  Company,  even if such  request  occurs after the
Employment  Period.  The Company shall pay  Executive's  reasonable  expenses of
cooperating  with the Company in  protecting  the  Company's  interests  in such
Intellectual  Property unless the subject matter of the requested cooperation is
related  to  actions  taken or failed  to be taken by  Executive  wrongfully  or
otherwise not in good faith.

         11. Executive's  Rights.  Paragraph 10 of this Agreement does not apply
to an invention  for which no  equipment,  supplies,  facilities or trade secret
information  of the  Company  was used  and  which  was  developed  entirely  on
Executive's  own time,  unless (a) the invention  relates (i) to the business of
the  Company,  or (ii)  to the  Company's  actual  or  demonstrably  anticipated
material  research or  development,  or (b) the invention  results from any work
performed by Executive for the Company.

         12. Return of Materials.  Upon termination of the Employment Period, or
at any time  reasonably  requested  by the  Company,  Executive  shall  promptly
deliver to the Company all copies of  Confidential  Information  in  Executive's
possession  and control,  including  written  records,  manuals,  lab notebooks,
customer and supplier lists and all other materials  containing any Confidential
Information.   If  the  Company   requests,   Executive  shall  provide  written
confirmation  that  Executive  has returned all such  materials.  Subject to the
provisions  of this  Agreement,  including,  without  limitation,  Paragraph 11,
notwithstanding  anything in this Agreement to the contrary, upon termination of
the  Employment  Period,  the Company,  at Executive's  request,  shall promptly
return to Executive any  equipment or other  materials  owned by Executive  then
being used by or then in the possession of the Company.

         13. Non-Competition.  Executive acknowledges and agrees that during the
Employment  Period and for a period of five years  thereafter (the  "Non-compete
Period"),  Executive will not, without the prior written consent of the Company,
directly or indirectly,  provide products or services  substantially  similar to
the  Employment  Services to any  business or entity that  provides or offers or
demonstrably  plans to provide or offer,  products or services  that (i) are the
same as or  substantially  similar to the  products or services  provided by the
Company at any time during the Employment  Period,  (ii) relate to the Company's
Intellectual  Property (whether the Company acquired such Intellectual  Property
pursuant to this Agreement or otherwise),  or (iii) relate to any subject matter
of the  Company's  actual or  demonstrably  anticipated  material  research  and
development during the Employment Period,  including without limitation,  taxol,
taxanes  and any other  compounds,  within  any  geographical  area in which the
Company or any of its  subsidiaries  provide or plan to provide such products or
services.

         14. Non-Solicitation. Executive acknowledges and agrees that during the
Non-compete Period Executive will not (a) solicit,  induce or attempt to induce,
directly or  indirectly,  any employee of the Company to leave the employment of
the Company to work for Executive or for any other person,  firm or  corporation
or (b) hire any employee of the Company.


                                        7

<PAGE>



         15. Acknowledgment of Reasonableness. Executive acknowledges and agrees
that the  limitations  set forth in  Paragraphs  13 and 14 are  reasonable  with
respect to scope, duration and geographic area and are properly required for the
protection of the legitimate business interest of the Company.

         16. Further Assistance.  During the Non-compete Period,  Executive will
not make any disclosure or other  communication to any person,  issue any public
statements or otherwise cause to be disclosed any information which is designed,
intended or might reasonably be anticipated to discourage any persons from doing
business with the Company or otherwise have a negative  impact or adverse effect
on the Company,  except to the extent such disclosure is required by law. During
the Non-compete Period,  Executive will provide assistance  reasonably requested
by the  Company  in  connection  with  actions  taken by  Executive  during  the
Employment  Period,  including but not limited to assistance in connection  with
any lawsuits or other claims against the Company  arising from events during the
Employment  Period,  provided  that the Company shall  reimburse all  reasonable
expenses  (including  without  limitation,  reasonable loss of compensation from
other sources resulting from such assistance during normal business hours).

         17.      Certain Definitions.

                  "Affiliate"  means  a  person  that  directly,  or  indirectly
through one or more intermediaries,  controls,  or is controlled by, or is under
common control with, the person specified.

                  "Confidential  Information" means all information  (whether or
not specifically labeled or identified as confidential),  in any form or medium,
that is disclosed to, or developed or learned by Executive during the Employment
Period  and prior to the  Employment  Period  during the  period  Executive  was
employed  by or engaged in research or  development  activities  for or with the
Company or its  predecessors  and  affiliates  or that relates to the  business,
products,  services,  customers,  research or  development  of the Company,  its
Subsidiaries,  its  Affiliates,  or third  parties  with whom the  Company,  its
Subsidiaries  or its  Affiliates  does  business or from whom the Company or its
Affiliates receives information.  Confidential Information shall not include any
information that (i) has become publicly known through no wrongful act or breach
of any  obligation  of  confidentiality,  as  evidenced  by  written  records or
documents;  or (ii) was rightfully  received by Executive on a  non-confidential
basis  from a third  party  (provided  that  such  third  party is not  known to
Executive to be bound by a confidentiality agreement with the Company or another
party), as evidenced by written records or documents.

                  "Independent  Third  Party"  means  any  person,  including  a
"group" as defined in Section  13(d)(3) of the Securities  Exchange Act of 1934,
as amended, and the rules and regulations thereunder,  who, immediately prior to
the  contemplated  transaction,  does not own in excess  of 5% of the  Company's
Common Stock on a fully-diluted basis, who is not controlling,  controlled by or
under common  control with any such 5% owner of the  Company's  Common Stock and
who is not the spouse or descendent  (by birth or adoption) of any such 5% owner
of the Company's Common Stock.

                  "Intellectual  Property"  means any idea,  invention,  design,
development,  device, method or process (whether or not patentable or reduced to
practice or including Confidential

                                        8

<PAGE>



Information) and all related patents and patent applications,  any copyrightable
work or mask work (whether or not including  Confidential  Information)  and all
related   registrations  and  applications  for  registration,   and  all  other
proprietary rights.

                  "Subsidiaries"  means any  corporation of which the securities
having a majority of the voting power in electing  directors are, at the time of
determination,   owned  by  the  Company,   directly  or  through  one  of  more
Subsidiaries.

         18. Executive Representations. Executive hereby represents and warrants
to the  Company  that  (a)  the  execution,  delivery  and  performance  of this
Agreement by Executive does not and will not conflict with,  breach,  violate or
cause a default under any contract,  agreement,  instrument,  order, judgment or
decree to which  Executive is a party or by which he is bound,  and (b) upon the
execution and delivery of this Agreement by the Company, this Agreement shall be
the valid and binding  obligation of Executive,  enforceable in accordance  with
its terms.

         19. Company Representations. The Company hereby represents and warrants
to Executive that (a) the execution,  delivery and performance of this Agreement
by the Company does not and will not conflict with,  breach,  violate or cause a
default under any contract, agreement,  instrument, order, judgment or decree to
which Company is a party or by which it is bound, and (b) upon the execution and
delivery of this Agreement by Executive,  this Agreement  shall be the valid and
binding obligation of the Company, enforceable in accordance with its terms.

         20.  Severability and Modification.  If any provision of this Agreement
shall be held or declared to be illegal, invalid or unenforceable, such illegal,
invalid or unenforceable  provision shall not affect any other provision of this
Agreement,  and the remainder of this Agreement shall continue in full force and
effect as though such provision had not been contained in this Agreement. If the
scope of any  provision  in this  Agreement  is found to be too  broad to permit
enforcement of such provision to its full extent, Executive consents to judicial
modification of such provision and  enforcement to the maximum extent  permitted
by law.

         21. Notices. Except as otherwise expressly set forth in this Agreement,
all notices, requests and other communications to be given or delivered under or
by reason of the provisions of this  Agreement  shall be in writing and shall be
given (and, except as otherwise  provided in this Agreement,  shall be deemed to
have  been  duly  given if so  given)  when  delivered  if given in person or by
telegram,  three days after being mailed by first class  registered or certified
mail,  return receipt  requested,  postage prepaid,  or one day after being sent
prepaid  via  reputable  overnight  courier  to the  parties  at  the  following
addresses  (or such  other  address  as shall be  furnished  in  writing by like
notice;  provided,  however, that notice of change of address shall be effective
only upon receipt):

Notices to Executive
         David L. Denny
         c/o NaPro BioTherapeutics, Inc.
         6304 Spine Road, Unit A
         Boulder, Colorado  80301



                                        9

<PAGE>

Notices to Company
         NaPro BioTherapeutics,
         6304 Spine Road, Unit A
         Boulder, Colorado 80301

         Attn.:   Patricia A. Pilia, Ph.D.
                  Executive Vice President

         with a copy to:
         Holme Roberts & Owen
         1700 Lincoln, Suite 4100
         Denver, CO 80203

         Attn.:  Francis Wheeler

     22. Entire Agreement.  This Agreement contains the entire agreement between
the  parties  with  respect to the  subject  matter  hereof and  supersedes  any
previous  understandings or agreements,  whether written or oral, regarding such
subject matter.

     23. Governing Law. All questions concerning the construction,  validity and
interpretations  of this Agreement will be governed by the internal law, and not
the law of conflicts, of the State of Colorado.

     24.  Survival.  Paragraphs  6, 9, 10,  11,  12, 13, 14 and 16 and any other
provision of this Agreement which by its terms could survive  termination of the
Employment  Period shall survive and continue in full force in  accordance  with
their terms notwithstanding any termination of the Employment Period.

     25. Counterparts.  This Agreement may be executed in separate counterparts,
each of which is  deemed  to be an  original  and all of  which  taken  together
constitute one and the same agreement.

     26. Successors and Assigns. This Agreement is intended to bind and inure to
the benefit of and be enforceable by Executive, the Company and their respective
successors and assigns;  provided that in no event shall Executive's obligations
under this  Agreement  be  delegated  or  transferred  by  Executive,  nor shall
Executive's  rights be subject to  encumbrance  or to the claims of  Executive's
creditors.  This  Agreement  is for the sole  benefit of the parties  hereto and
shall not create any rights in third  parties other than  Executive's  spouse or
beneficiary as expressly set forth herein.

     27. Remedies.  Except as otherwise provided in this Agreement,  (i) each of
the parties to this  Agreement will be entitled to enforce its rights under this
Agreement  specifically,  to  recover  damages  by reason  of any  breach of any
provision of this  Agreement and to exercise all other rights to which it may be
entitled and (ii) disputes under this Agreement not finally  resolved in writing
by the parties  within  sixty days after one party gives notice in good faith to
the other party that a bona fide dispute  exists  shall be resolved  pursuant to
binding arbitration  conducted in Denver,  Colorado in accordance with the rules
of the  American  Arbitration  Association.  The  prevailing  party  in any such
arbitration  shall  be  entitled  to have  its  costs  and  expenses  (including
reasonable attorney's fees

                                       10

<PAGE>



and  expenses)  relating  to such  arbitration  paid by the  other  party if the
arbitrator(s)  conducting  such  arbitration so determine.  Notwithstanding  the
foregoing,  the parties agree and  acknowledge  that money damages may not be an
adequate  remedy for breach of the  provisions  of this  Agreement  and that any
party  may in its  sole  discretion  apply  to any  court  of law or  equity  of
competent  jurisdiction for specific  performance  and/or  injunctive  relief in
order to enforce or prevent any violations of the provisions of this  Agreement.
The  prevailing  party  in any suit  shall be  entitled  to  recover  reasonable
attorneys fees and costs from the other party.

     28.  Modifications  and  Waivers.  No provision  of this  Agreement  may be
modified,  altered or amended except by an instrument in writing executed by the
parties  hereto.  No waiver by either  party  hereto of any  breach by the other
party hereto of any term or provision of this  Agreement to be performed by such
other  party  shall  be  deemed a  waiver  of  similar  or  dissimilar  terms or
provisions at the time or at any prior or subsequent time.

     29. Headings.  The headings  contained herein are solely for the purpose of
reference,  are not part of this  Agreement  and shall not in any way affect the
meaning or interpretation of this Agreement.

         30.  Notification  of Subsequent  Employer.  Executive  agrees that the
     Company may present a copy of this Agreement to any third party.

     31.  UNDERSTAND  AGREEMENT.  EXECUTIVE  REPRESENTS  AND  WARRANTS  THAT (a)
EXECUTIVE HAS READ AND UNDERSTOOD  EACH AND EVERY  PROVISION OF THIS  AGREEMENT,
(b)  EXECUTIVE  HAS HAD THE  OPPORTUNITY  TO OBTAIN ADVICE FROM LEGAL COUNSEL OF
EXECUTIVE'S  CHOICE,  OTHER THAN COUNSEL TO THE COMPANY (WHO IS NOT REPRESENTING
THE EXECUTIVE),  IN ORDER TO INTERPRET ANY AND ALL PROVISIONS OF THIS AGREEMENT,
(c) EXECUTIVE HAS HAD THE  OPPORTUNITY TO ASK THE COMPANY  QUESTIONS  ABOUT THIS
AGREEMENT  AND ANY OF SUCH  QUESTIONS  EXECUTIVE HAS ASKED HAVE BEEN ANSWERED TO
EXECUTIVE'S  SATISFACTION,  AND  (d)  EXECUTIVE  HAS  BEEN  GIVEN A COPY OF THIS
AGREEMENT.

         IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
duly executed on the day and year first above written.

                              EXECUTIVE

                                       /s/ David L. Denny
                              -----------------------------------
                                       David L. Denny


                              NAPRO BIOTHERAPEUTICS, INC.


                              By:      /s/ Gordon H. Link, Jr.
                                       Gordon H. Link, Jr.
                                       Vice President, Finance and
                                       Chief Financial Officer



                                                        11

<PAGE>



                              EMPLOYMENT AGREEMENT

         THIS AGREEMENT (the "Agreement") is entered into effective this 5th day
of October,  1998 (the "Effective Date"), by and between NaPro  BioTherapeutics,
Inc.,  a  Delaware  corporation  (the  "Company"),   and  William  D.  Fairbairn
("Executive"). Certain capitalized terms used in this Agreement have the meaning
set forth in Paragraph 17 hereof.

                                    RECITALS

         A.       WHEREAS, Executive is currently employed by the Company; and

         B. WHEREAS,  the Company  desires to secure the  continued  services of
Executive as an employee of the Company, and to provide for certain compensation
and benefit  arrangements for Executive in the event of Executive's  termination
of  employment  under certain  circumstances,  and Executive is willing to enter
into this Agreement and perform such services.

                              TERMS AND CONDITIONS

         In  consideration  of the  respective  covenants and  agreements of the
parties contained in this Agreement, the parties agree as follows:

         1. Employment Services.  The Company hereby agrees to engage Executive,
and Executive  hereby agrees to perform  services for the Company,  on the terms
and conditions  set forth in this  Agreement.  During the Employment  Period (as
defined below),  the Company and Executive agree that Executive will serve as an
executive  officer of the Company in the position of Vice President,  Regulatory
Affairs with the duties, responsibilities and authority as set forth on Schedule
A, or will have such  other  executive  title and such other  executive  duties,
responsibilities  and authority as Executive and the Company may agree upon from
time to time, and will perform such services of an executive and  administrative
character to the Company and its present or future Subsidiaries  consistent with
the duties of the Company's other executive officers,  as the Company's Board of
Directors (the "Board") may from time to time direct (the "Employment Services")
or the Bylaws of the Company may provide. The Employment Services shall commence
upon the Effective Date of this Agreement and terminate as provided in Paragraph
6 (the "Employment Period").

         2.       Performance.

                  (a) Executive shall report to the Executive Vice President (or
person  acting  in a similar  capacity  if the  Company  has no  Executive  Vice
President),  and  Executive  shall devote his best efforts and his full business
time and attention  (except for permitted  vacation  periods) to the business of
the Company and its Subsidiaries;  provided,  however, that upon prior agreement
by the Executive  Vice  President,  and subject to the terms of this  Agreement,
Executive  may  engage  in  independent  activities  in areas  unrelated  to the
Company's business or the Company's actual or demonstrably anticipated business;
and provided,  further,  that no such  independent  activities  shall materially
detract from the  essentially  full time commitment of Executive to the business
and  affairs  of  the   Company.   Executive   shall   perform  his  duties  and
responsibilities  to the  best  of his  abilities  in a  diligent,  trustworthy,
businesslike and professional manner.



<PAGE>



                  (b)  Unless  the  Company  and  Executive   otherwise   agree,
Executive  shall  perform the  Employment  Services at the  Company's  executive
offices and traveling on business as Executive and the Company shall  reasonably
deem necessary.

         3.       Compensation.

                  (a)  During  the  Employment  Period,  the  Company  will  pay
Executive for the  Employment  Services a base salary (the "Base Salary") at the
annual  rate  of  $110,000  or such  other  increased  rate as the  compensation
committee of the Board or Board committee  performing  equivalent functions (the
"Compensation  Committee") (or if the Board has no Compensation Committee at the
time, then the Board) may designate from time to time, such salary to be paid at
such periods as salary is paid to other executive  officers of the Company.  The
Compensation  Committee  (or the Board,  if  applicable)  shall  review the Base
Salary of the Executive at least  annually on the  anniversary  of the Effective
Date and may, in its sole  discretion,  increase  (but not  decrease)  such Base
Salary  from time to time.  Payment of the Base  Salary  shall be subject to the
customary withholding tax and other employment taxes as required with respect to
compensation paid by a corporation to an employee.

                  (b) Executive  may receive an annual bonus in such amount,  if
any,  as  the  Compensation  Committee  (or  if the  Board  has no  Compensation
Committee  at the  time,  then  the  Board),  in its  discretion,  may  award to
Executive, based upon Executive's and the Company's performance during each year
of the Employment  Period,  provided,  however that each annual bonus payable to
Executive during the Employment Period shall not be less than the greater of (i)
$15,000 or (ii) the amount of the highest annual bonus paid to Executive for the
three most recent fiscal years of the Company.

                  (c) The  Executive  shall be  entitled  to receive  such stock
options  during the  Employment  Period as  determined  from time to time by the
Compensation  Committee  (or if the Board has no  Compensation  Committee at the
time, then the Board).

         4.  Reimbursement  for Expenses.  The Company shall promptly  reimburse
Executive  for all  reasonable  out-of-pocket  expenses  incurred  by him in the
course of performing his duties under this  Agreement,  subject to the Company's
reasonable  requirements  with respect to reporting  and  documentation  of such
expenses.

         5. Benefits. Executive shall be entitled to all fringe benefits offered
by the Company  and to  participate  in all of the  Company's  employee  benefit
programs both on the same basis as available to  executives of the Company,  and
shall be  entitled  to such  other  benefits  as may  from  time to time be made
available to  Executive.  The Company  shall use  commercially  reasonable  best
efforts to obtain and keep directors' and officers' liability insurance coverage
in effect in an amount equivalent to that of a well-insured,  similarly-situated
company;  provided,  however, that the failure to obtain and keep such insurance
in effect after the Company has  exercised  such  commercially  reasonable  best
efforts shall not be a breach of the Company's obligations under this Agreement.
During the Employment Period,  Executive shall be entitled to four weeks of paid
vacation during each year of the Employment Period and may carry over up to four
weeks of vacation from one year to the next succeeding year only.

                                        2

<PAGE>



         6.       Term and Termination.

                  (a)  Except  as  otherwise  provided  in this  Agreement,  the
Employment Period shall terminate upon the earlier of:

     (i) three  years from the  Effective  Date  hereof  (the  "Initial  Term");
provided,  however,  that the  Employment  Period  shall be extended by one year
after  the  Initial  Term and each year  thereafter  on the  anniversary  of the
Effective Date of this Agreement (each such extension,  a "Renewal Term") unless
either Executive or the Board shall have given written notice to the other party
no later than 180 days prior to the  commencement  of any Renewal Term of his or
its  desire  to  terminate  the  Employment  Period  on the  date  prior  to the
commencement of such Renewal Term;

     (ii) Executive's  incapacity or permanent  disability (which in either case
shall be deemed to occur only in the event  Executive  is unable to perform  the
Employment Services for 180 days in any 12-month period) or death;

     (iii)  termination by Executive  voluntarily or for Good Reason (as defined
below);

     (iv) termination by the Company with or without Cause (as defined below).

                  (b) If the Employment  Period is terminated (i) by the Company
without  Cause or (ii) by Executive  for Good Reason,  then  Executive  shall be
entitled to receive,  so long as Executive  has not breached the  provisions  of
Paragraphs  9, 10,  12, 13,  14, or 16 hereof in a manner  that could  adversely
affect  the  Company,  his  Base  Salary  in cash at the  periods  set  forth in
Paragraph 3, at a rate equal to the then  applicable rate set forth in Paragraph
3 for a period equal to the greater of (x) the  remainder of the Initial Term or
the then current  Renewal  Term, as  applicable,  or (y) one year plus in either
case (I) the greater of (A) the most recent  annual  bonus,  if any,  awarded to
Executive  pursuant to  Paragraph  3(b) during the  Company's  fiscal year of or
during the Company's  fiscal year prior to termination,  as the case may be, (B)
the  average  amount  of the last  three  annual  bonuses,  if any,  awarded  to
Executive  pursuant to  Paragraph  3(b) prior to  termination,  or (C)  $15,000,
multiplied by in any case not less than the number of years for which  Executive
is entitled to receive his Base Salary pursuant to this Paragraph 6(b) (prorated
for any partial  year) (such bonus amounts to be paid pro rata over the term for
which  Executive  is  entitled  to  receive  his Base  Salary  pursuant  to this
Paragraph  6(b));  plus (II) at Executive's  election,  medical,  dental and any
other health  insurance,  life  insurance,  accidental  death and  dismemberment
insurance  and  disability  protection  no less  favorable to Executive  and his
dependents  covered thereby  (including that Executive shall remain obligated to
continue  to pay any  costs or  expenses  which  Executive  would  otherwise  be
obligated  to pay  pursuant  to such  insurance  or other  protections  provided
pursuant to Paragraph 5 as in existence on the date of such  termination)  until
the first to occur of (i) the date of Executive's  re-employment  and subsequent
opportunity  to  participate  in any health  insurance  program with  comparable
coverage provided by such new employer,  including without limitation,  coverage
with respect to any  pre-existing  conditions or (ii) eighteen months after such
termination date.

                                        3

<PAGE>



                  (c) If a Change of  Control  (as  defined  below)  occurs  and
Executive  is  thereafter  offered and  accepts  continued  employment  with the
Company (or its  successor),  and either (i) he is still employed by the Company
on the  first  calendar  anniversary  of the  Change  of  Control,  or (ii)  his
employment  with the Company is  terminated  by the Company  without Cause or he
terminates  his  employment  for Good Reason  during such one year  period,  the
Company shall pay Executive, in addition to any other amounts payable hereunder,
a "stay bonus"  equal to one year's then current Base Salary.  Such "stay bonus"
shall be paid in a cash lump sum to Executive  within twenty (20) days following
the earlier of (i) the first anniversary of the date of the Change of Control or
(ii) the date of his termination of employment with the Company. For purposes of
this  Agreement,  a  "Change  of  Control"  means  the  happening  of any of the
following:  (i) the merger or  consolidation of the Company into a new surviving
company  in  which  the  holders  of  the  Company's  voting  securities  (on  a
fully-diluted  basis)  immediately prior to the merger or consolidation own less
than a majority  of the  ordinary  voting  power to elect  directors  of the new
surviving  company  (on a fully  diluted  basis),  or (ii) when any  "person" as
defined in Section 3(a)(9) of the Securities Exchange Act of 1934 (the "34 Act")
and as used in Sections 13(d) and 14(d) thereof,  including a "group" as defined
in Section 13(d) of the 34 Act but  excluding the Company and any  Subsidiary or
any  employee  benefit  plan  sponsored  or  maintained  by the  Company  or any
Subsidiary  (including  a trustee of such plan acting as  trustee),  directly or
indirectly,  becomes the "beneficial  owner" (as defined in Rule 13d-3 under the
34 Act, as amended from time to time), of securities of the Company representing
25% or more of the  combined  voting  power of the  Company's  then  outstanding
securities.

                  (d)  Except  as  provided  in  Paragraphs  6(b) or  (c),  upon
termination of the  Employment  Period,  Executive  shall be entitled to receive
only  (i)  accrued  but  unpaid  salary  and  bonus  through  the  date  of such
termination and (ii) unpaid salary with respect to any vacation days accrued but
not taken as of the date of such termination.

                  (e) For purposes of this Agreement, "Cause" shall mean (i) the
conviction (or plea of nolo  contendere) of a felony or a crime  involving moral
turpitude or the  commission of any other act which has an adverse effect on the
Company and which involves  dishonesty,  disloyalty or fraud with respect to the
Company or any of its Subsidiaries,  (ii) conduct bringing the Company or any of
its  Subsidiaries  into  substantial  public  disgrace or disrepute,  including,
without limitation, such conduct resulting from repeated acts of alcohol or drug
abuse, (iii) continued failure by Executive to substantially  perform his duties
as reasonably  directed by the Board for a period of 15 days after the Board has
made a demand for  substantial  performance  which  specifically  identifies the
manner  in  which  the  Board  believes  that  Executive  has not  substantially
performed his duties,  or (iv) gross  negligence or misconduct not in good faith
with  respect  to the  Company  or any of its  Subsidiaries,  or (v)  any  other
material  breach  of this  Agreement  which is not cured  within  15 days  after
Executive's receipt of written notice thereof.

                  (f)  For  purposes  of  this  Agreement,  termination  of  the
Employment  Period by Executive  for "Good  Reason"  shall mean  termination  by
Executive  (i) within 90 days after  Executive  has been  assigned,  without his
consent,  to any duties  substantially  inconsistent with his position,  duties,
responsibilities  or status with the Company as  contemplated  in Paragraph 1 of
this Agreement;  (ii) following a Change of Control, upon failure of the Company
to pay  Executive  an annual  bonus equal to the  average  amount of such annual
bonus paid to Executive during the three

                                        4

<PAGE>



fiscal years of the Company  immediately  preceding the year in which the Change
of Control occurs;  (iii) following a reduction of Executive's Base Salary after
a Change of Control;  (iv) if  Executive  is required to  regularly  perform the
duties of his employment more than 50 miles from Boulder,  Colorado; or (v) upon
a material  breach of this Agreement by the Company which is not cured within 30
days after the Company's  receipt of written  notice  thereof.  Executive  shall
provide  written  notice to the  Company of any and all grounds  that  Executive
alleges  constitute  "Good  Reason"  and the  Company  shall  have 30 days after
receipt  of such  written  notice  to cure any such  alleged  grounds  for "Good
Reason".  If,  following the expiration of such 30 day period,  Executive  still
believes  that "Good  Reason"  exists for his  termination  of  Employment,  the
provisions of Paragraph 7 shall apply.

                  (g) Promptly  (but in any event within 20 days)  following any
termination  of the  Employment  Period,  and as of that date,  the Company will
notify  Executive of the itemized and  aggregate  cash value of the payments and
benefits,  as determined  under  Section 280G of the Internal  Revenue Code (the
"Code"),  received  or to be  received  by  Executive  in  connection  with  the
termination of his  employment  (whether  payable  pursuant to the terms of this
Agreement or otherwise). At the same time, the Company shall advise Executive of
the portion of such payments or benefits  which  constitute  parachute  payments
within the meaning of the Code and which may subject Executive to the payment of
excise  taxes  pursuant to Section  4999 and the  expected  amount of such taxes
(such  payments  or  benefits  being  hereinafter   referred  to  as  "Parachute
Payments").

                  (h)  Notwithstanding  the provisions of Paragraph 6(b) hereof,
if all or any portion of the payments or benefits  provided under Paragraph 6(b)
either alone or together  with other  payments or benefits  which  Executive has
received  or is  then  entitled  to  receive  from  the  Company  and any of its
Subsidiaries  would  constitute  Parachute  Payments,  such payments or benefits
provided  to  Executive  under  Paragraph  6(b)  shall be  reduced to the extent
necessary so that no portion  thereof shall be subject to the excise tax imposed
by  Section  4999 of the  Code;  but  only  if,  by  reason  of such  reduction,
Executive's net after tax benefit shall exceed the net after tax benefit if such
reduction were not made.  "Net after tax benefit" for purposes of this Paragraph
6(h)  shall mean the sum of (i) the total  amount  payable  to  Executive  under
Paragraphs 6(b) and (c) hereof,  plus (ii) all other payments and benefits which
Executive  has received or is then  entitled to receive from the Company and any
of its subsidiaries  that would constitute a Parachute  Payment,  less (iii) the
amount of federal  income taxes payable with respect to the payment and benefits
described in (i) and (ii) above  calculated at the maximum  marginal  income tax
rate  for  each  year in  which  such  payments  and  benefits  shall be paid to
Executive  (based upon the rate in effect for such year as set forth in the Code
at the  Termination  Date),  less (iv) the amount of excise  taxes  imposed with
respect to the payments and benefits  described in (i) and (ii) above by Section
4999 of the Code.

                  For purposes of this Paragraph 6(h),  Executive's base amount,
the present  value of the Parachute  Payments,  the amount of the excise tax and
all other appropriate  matters shall be determined by the Company's  independent
auditors in accordance with the principles of Section 280G of the Code and based
upon the advice of tax counsel selected by the Company,  which tax counsel shall
be reasonably satisfactory to Executive.

         7.  Notice of Certain  Terminations.  In the event that  either (i) the
Company shall  terminate  Executive for Cause or (ii) Executive  shall terminate
for Good Reason,  then any such  termination  shall be  communicated  by written
notice to the other party hereto. Any such notice shall

                                        5

<PAGE>



specify(x) the effective date of  termination of the Employment  Period,  which,
except as otherwise  provided in Paragraph 6(f),  shall not be more than 30 days
after the date the notice is delivered (the "Termination Effective Date" and (y)
in reasonable detail the facts and circumstances underlying a determination that
the  termination is for Cause or for Good Reason,  as the case may be. If within
15 days after any notice of termination of Executive for Cause by the Company is
given,  or if  within 15 days  after  the  Company's  30 day cure  period  under
Paragraph 6(f) has expired,  the party  receiving such notice notifies the other
party that a good faith dispute exists  concerning the  characterization  of the
termination,  the  Termination  Effective  Date  shall be the date on which such
dispute is finally  resolved  either by written  agreement  of the parties or by
binding arbitration  conducted pursuant to the rules of the American Arbitration
Association. Notwithstanding the pendency of any such dispute, the Company shall
continue Executive and his dependents as participants in all medical, dental and
any other health  insurance and similar benefit plans of the Company in which he
and they were  participating  when the notice  giving  rise to the  dispute  was
given,  until the  dispute is finally  resolved.  Benefits  provided  under this
Paragraph 7 are in addition to all other  amounts due under this  Agreement  and
shall not be  offset  against,  or reduce  any other  amounts  due  under,  this
Agreement.

         8.  Insurance.  The Company  may, at its  election and for its benefit,
insure Executive  against  accidental  death, and Executive shall submit to such
physical  examination  and  supply  such  information  as  may  be  required  in
connection therewith.

         9.       Non-disclosure of Confidential Information.

                  (a) Unless  Executive  first secures  written consent from the
Company  pursuant to  procedures  implemented  by Company after the date hereof,
Executive  shall not disclose or use at any time,  either during the  Employment
Period or thereafter,  any Confidential Information (as defined in Paragraph 17)
except to the extent Executive  reasonably  believes is necessary to disclose or
use  such  Confidential  Information  in  performing  the  Employment  Services.
Executive  further agrees that Executive will use  Executive's  commercial  best
efforts  to  safeguard  the  Confidential  Information  and  protect  it against
disclosure,  misuse, espionage,  loss and theft, including,  without limitation,
causing  recipients of  Confidential  Information  to enter into  non-disclosure
agreements with the Company.  Subject to the provisions of Paragraphs 10 and 13,
nothing herein shall be construed to prevent  Executive  from using  Executive's
general  knowledge  and  skill  after  termination  of this  Agreement,  whether
Executive  acquired  such  knowledge  or skill  before or during the  Employment
Period.

                  (b) In the event the Company has entered into  confidentiality
agreements with third parties (not including  Company  employees)  which contain
provisions  different from those set forth in this Agreement,  Executive agrees,
in  addition  to the  provisions  of  Paragraph  9(a),  to comply  with any such
different provisions of which Executive is notified by the Company.

         10.  Company  Ownership  of  Intellectual  Property.  Executive  hereby
assigns to the Company all right,  title and interest in and to all Intellectual
Property (as defined in  Paragraph  17)  contributed  to or conceived or made by
Executive during the Employment Period and prior to the Employment Period during
the period  Executive  was  employed by or engaged in  research  or  development
activities for or with the Company or its predecessors  and affiliates  (whether
alone or jointly  with others) to the extent such  Intellectual  Property is not
owned by the Company as a matter

                                        6

<PAGE>



of law.  Executive  shall  promptly  and fully  communicate  to the  Company all
Intellectual  Property conceived,  contributed to or made by Executive and shall
cooperate  with  the  Company  to  protect  the  Company's   interests  in  such
Intellectual  Property including,  without limitation,  providing  assistance in
securing patent protection and copyright registrations and signing all documents
reasonably  requested  by the  Company,  even if such  request  occurs after the
Employment  Period.  The Company shall pay  Executive's  reasonable  expenses of
cooperating  with the Company in  protecting  the  Company's  interests  in such
Intellectual  Property unless the subject matter of the requested cooperation is
related  to  actions  taken or failed  to be taken by  Executive  wrongfully  or
otherwise not in good faith.

         11. Executive's  Rights.  Paragraph 10 of this Agreement does not apply
to an invention  for which no  equipment,  supplies,  facilities or trade secret
information  of the  Company  was used  and  which  was  developed  entirely  on
Executive's  own time,  unless (a) the invention  relates (i) to the business of
the  Company,  or (ii)  to the  Company's  actual  or  demonstrably  anticipated
material  research or  development,  or (b) the invention  results from any work
performed by Executive for the Company.

         12. Return of Materials.  Upon termination of the Employment Period, or
at any time  reasonably  requested  by the  Company,  Executive  shall  promptly
deliver to the Company all copies of  Confidential  Information  in  Executive's
possession  and control,  including  written  records,  manuals,  lab notebooks,
customer and supplier lists and all other materials  containing any Confidential
Information.   If  the  Company   requests,   Executive  shall  provide  written
confirmation  that  Executive  has returned all such  materials.  Subject to the
provisions  of this  Agreement,  including,  without  limitation,  Paragraph 11,
notwithstanding  anything in this Agreement to the contrary, upon termination of
the  Employment  Period,  the Company,  at Executive's  request,  shall promptly
return to Executive any  equipment or other  materials  owned by Executive  then
being used by or then in the possession of the Company.

         13. Non-Competition.  Executive acknowledges and agrees that during the
Employment  Period and for a period of five years  thereafter (the  "Non-compete
Period"),  Executive will not, without the prior written consent of the Company,
directly or indirectly,  provide products or services  substantially  similar to
the  Employment  Services to any  business or entity that  provides or offers or
demonstrably  plans to provide or offer,  products or services  that (i) are the
same as or  substantially  similar to the  products or services  provided by the
Company at any time during the Employment  Period,  (ii) relate to the Company's
Intellectual  Property (whether the Company acquired such Intellectual  Property
pursuant to this Agreement or otherwise),  or (iii) relate to any subject matter
of the  Company's  actual or  demonstrably  anticipated  material  research  and
development during the Employment Period,  including without limitation,  taxol,
taxanes  and any other  compounds,  within  any  geographical  area in which the
Company or any of its  subsidiaries  provide or plan to provide such products or
services.

         14. Non-Solicitation. Executive acknowledges and agrees that during the
Non-compete Period Executive will not (a) solicit,  induce or attempt to induce,
directly or  indirectly,  any employee of the Company to leave the employment of
the Company to work for Executive or for any other person,  firm or  corporation
or (b) hire any employee of the Company.


                                        7

<PAGE>



         15. Acknowledgment of Reasonableness. Executive acknowledges and agrees
that the  limitations  set forth in  Paragraphs  13 and 14 are  reasonable  with
respect to scope, duration and geographic area and are properly required for the
protection of the legitimate business interest of the Company.

         16. Further Assistance.  During the Non-compete Period,  Executive will
not make any disclosure or other  communication to any person,  issue any public
statements or otherwise cause to be disclosed any information which is designed,
intended or might reasonably be anticipated to discourage any persons from doing
business with the Company or otherwise have a negative  impact or adverse effect
on the Company,  except to the extent such disclosure is required by law. During
the Non-compete Period,  Executive will provide assistance  reasonably requested
by the  Company  in  connection  with  actions  taken by  Executive  during  the
Employment  Period,  including but not limited to assistance in connection  with
any lawsuits or other claims against the Company  arising from events during the
Employment  Period,  provided  that the Company shall  reimburse all  reasonable
expenses  (including  without  limitation,  reasonable loss of compensation from
other sources resulting from such assistance during normal business hours).

         17.      Certain Definitions.

                  "Affiliate"  means  a  person  that  directly,  or  indirectly
through one or more intermediaries,  controls,  or is controlled by, or is under
common control with, the person specified.

                  "Confidential  Information" means all information  (whether or
not specifically labeled or identified as confidential),  in any form or medium,
that is disclosed to, or developed or learned by Executive during the Employment
Period  and prior to the  Employment  Period  during the  period  Executive  was
employed  by or engaged in research or  development  activities  for or with the
Company or its  predecessors  and  affiliates  or that relates to the  business,
products,  services,  customers,  research or  development  of the Company,  its
Subsidiaries,  its  Affiliates,  or third  parties  with whom the  Company,  its
Subsidiaries  or its  Affiliates  does  business or from whom the Company or its
Affiliates receives information.  Confidential Information shall not include any
information that (i) has become publicly known through no wrongful act or breach
of any  obligation  of  confidentiality,  as  evidenced  by  written  records or
documents;  or (ii) was rightfully  received by Executive on a  non-confidential
basis  from a third  party  (provided  that  such  third  party is not  known to
Executive to be bound by a confidentiality agreement with the Company or another
party), as evidenced by written records or documents.

                  "Independent  Third  Party"  means  any  person,  including  a
"group" as defined in Section  13(d)(3) of the Securities  Exchange Act of 1934,
as amended, and the rules and regulations thereunder,  who, immediately prior to
the  contemplated  transaction,  does not own in excess  of 5% of the  Company's
Common Stock on a fully-diluted basis, who is not controlling,  controlled by or
under common  control with any such 5% owner of the  Company's  Common Stock and
who is not the spouse or descendent  (by birth or adoption) of any such 5% owner
of the Company's Common Stock.

                  "Intellectual  Property"  means any idea,  invention,  design,
development,  device, method or process (whether or not patentable or reduced to
practice or including Confidential

                                        8

<PAGE>



Information) and all related patents and patent applications,  any copyrightable
work or mask work (whether or not including  Confidential  Information)  and all
related   registrations  and  applications  for  registration,   and  all  other
proprietary rights.

                  "Subsidiaries"  means any  corporation of which the securities
having a majority of the voting power in electing  directors are, at the time of
determination,   owned  by  the  Company,   directly  or  through  one  of  more
Subsidiaries.

         18. Executive Representations. Executive hereby represents and warrants
to the  Company  that  (a)  the  execution,  delivery  and  performance  of this
Agreement by Executive does not and will not conflict with,  breach,  violate or
cause a default under any contract,  agreement,  instrument,  order, judgment or
decree to which  Executive is a party or by which he is bound,  and (b) upon the
execution and delivery of this Agreement by the Company, this Agreement shall be
the valid and binding  obligation of Executive,  enforceable in accordance  with
its terms.

         19. Company Representations. The Company hereby represents and warrants
to Executive that (a) the execution,  delivery and performance of this Agreement
by the Company does not and will not conflict with,  breach,  violate or cause a
default under any contract, agreement,  instrument, order, judgment or decree to
which Company is a party or by which it is bound, and (b) upon the execution and
delivery of this Agreement by Executive,  this Agreement  shall be the valid and
binding obligation of the Company, enforceable in accordance with its terms.

         20.  Severability and Modification.  If any provision of this Agreement
shall be held or declared to be illegal, invalid or unenforceable, such illegal,
invalid or unenforceable  provision shall not affect any other provision of this
Agreement,  and the remainder of this Agreement shall continue in full force and
effect as though such provision had not been contained in this Agreement. If the
scope of any  provision  in this  Agreement  is found to be too  broad to permit
enforcement of such provision to its full extent, Executive consents to judicial
modification of such provision and  enforcement to the maximum extent  permitted
by law.

         21. Notices. Except as otherwise expressly set forth in this Agreement,
all notices, requests and other communications to be given or delivered under or
by reason of the provisions of this  Agreement  shall be in writing and shall be
given (and, except as otherwise  provided in this Agreement,  shall be deemed to
have  been  duly  given if so  given)  when  delivered  if given in person or by
telegram,  three days after being mailed by first class  registered or certified
mail,  return receipt  requested,  postage prepaid,  or one day after being sent
prepaid  via  reputable  overnight  courier  to the  parties  at  the  following
addresses  (or such  other  address  as shall be  furnished  in  writing by like
notice;  provided,  however, that notice of change of address shall be effective
only upon receipt):

Notices to Executive
         William D. Fairbairn
         c/o NaPro BioTherapeutics, Inc.
         6304 Spine Road, Unit A
         Boulder, Colorado  80301

Notices to Company

                                        9

<PAGE>


Notices to Company
         NaPro BioTherapeutics,
         6304 Spine Road, Unit A
         Boulder, Colorado 80301

         Attn.:   Patricia A. Pilia, Ph.D.
                  Executive Vice President

         with a copy to:
         Holme Roberts & Owen
         1700 Lincoln, Suite 4100
         Denver, CO 80203

         Attn.:  Francis Wheeler


     22. Entire Agreement.  This Agreement contains the entire agreement between
the  parties  with  respect to the  subject  matter  hereof and  supersedes  any
previous  understandings or agreements,  whether written or oral, regarding such
subject matter.

     23. Governing Law. All questions concerning the construction,  validity and
interpretations  of this Agreement will be governed by the internal law, and not
the law of conflicts, of the State of Colorado.

     24.  Survival.  Paragraphs  6, 9, 10,  11,  12, 13, 14 and 16 and any other
provision of this Agreement which by its terms could survive  termination of the
Employment  Period shall survive and continue in full force in  accordance  with
their terms notwithstanding any termination of the Employment Period.

     25. Counterparts.  This Agreement may be executed in separate counterparts,
each of which is  deemed  to be an  original  and all of  which  taken  together
constitute one and the same agreement.

     26. Successors and Assigns. This Agreement is intended to bind and inure to
the benefit of and be enforceable by Executive, the Company and their respective
successors and assigns;  provided that in no event shall Executive's obligations
under this  Agreement  be  delegated  or  transferred  by  Executive,  nor shall
Executive's  rights be subject to  encumbrance  or to the claims of  Executive's
creditors.  This  Agreement  is for the sole  benefit of the parties  hereto and
shall not create any rights in third  parties other than  Executive's  spouse or
beneficiary as expressly set forth herein.

     27. Remedies.  Except as otherwise provided in this Agreement,  (i) each of
the parties to this  Agreement will be entitled to enforce its rights under this
Agreement  specifically,  to  recover  damages  by reason  of any  breach of any
provision of this  Agreement and to exercise all other rights to which it may be
entitled and (ii) disputes under this Agreement not finally  resolved in writing
by the parties  within  sixty days after one party gives notice in good faith to
the other party that a bona fide dispute  exists  shall be resolved  pursuant to
binding arbitration  conducted in Denver,  Colorado in accordance with the rules
of the American Arbitration Association. The prevailing party in any

                                       10

<PAGE>



such  arbitration  shall be entitled to have its costs and  expenses  (including
reasonable  attorney's fees and expenses)  relating to such  arbitration paid by
the other party if the  arbitrator(s)  conducting such arbitration so determine.
Notwithstanding  the  foregoing,  the parties agree and  acknowledge  that money
damages  may not be an  adequate  remedy  for breach of the  provisions  of this
Agreement  and that any party may in its sole  discretion  apply to any court of
law  or  equity  of  competent  jurisdiction  for  specific  performance  and/or
injunctive  relief  in  order  to  enforce  or  prevent  any  violations  of the
provisions of this Agreement. The prevailing party in any suit shall be entitled
to recover reasonable attorneys fees and costs from the other party.

     28.  Modifications  and  Waivers.  No provision  of this  Agreement  may be
modified,  altered or amended except by an instrument in writing executed by the
parties  hereto.  No waiver by either  party  hereto of any  breach by the other
party hereto of any term or provision of this  Agreement to be performed by such
other  party  shall  be  deemed a  waiver  of  similar  or  dissimilar  terms or
provisions at the time or at any prior or subsequent time.

     29. Headings.  The headings  contained herein are solely for the purpose of
reference,  are not part of this  Agreement  and shall not in any way affect the
meaning or interpretation of this Agreement.

     30. Notification of Subsequent Employer.  Executive agrees that the Company
may present a copy of this Agreement to any third party.

     31.  UNDERSTAND  AGREEMENT.  EXECUTIVE  REPRESENTS  AND  WARRANTS  THAT (a)
EXECUTIVE HAS READ AND UNDERSTOOD  EACH AND EVERY  PROVISION OF THIS  AGREEMENT,
(b)  EXECUTIVE  HAS HAD THE  OPPORTUNITY  TO OBTAIN ADVICE FROM LEGAL COUNSEL OF
EXECUTIVE'S  CHOICE,  OTHER THAN COUNSEL TO THE COMPANY (WHO IS NOT REPRESENTING
THE EXECUTIVE),  IN ORDER TO INTERPRET ANY AND ALL PROVISIONS OF THIS AGREEMENT,
(c) EXECUTIVE HAS HAD THE  OPPORTUNITY TO ASK THE COMPANY  QUESTIONS  ABOUT THIS
AGREEMENT  AND ANY OF SUCH  QUESTIONS  EXECUTIVE HAS ASKED HAVE BEEN ANSWERED TO
EXECUTIVE'S  SATISFACTION,  AND  (d)  EXECUTIVE  HAS  BEEN  GIVEN A COPY OF THIS
AGREEMENT.

         IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
duly executed on the day and year first above written.

                                EXECUTIVE

                                         /s/ William D. Fairbairn
                                -----------------------------------
                                         William D. Fairbairn


                                NAPRO BIOTHERAPEUTICS, INC.



                                By:  /s/ Gordon H. Link, Jr.
                                     Gordon H. Link, Jr.
                                     Vice President, Finance and
                                     Chief Financial Officer



                                                        11

<PAGE>




                              EMPLOYMENT AGREEMENT

         THIS AGREEMENT (the "Agreement") is entered into effective this 5th day
of October,  1998 (the "Effective Date"), by and between NaPro  BioTherapeutics,
Inc.,  a  Delaware   corporation  (the   "Company"),   and  James  D.  McChesney
("Executive"). Certain capitalized terms used in this Agreement have the meaning
set forth in Paragraph 17 hereof.

                                    RECITALS

         A.       WHEREAS, Executive is currently employed by the Company; and

         B. WHEREAS,  the Company  desires to secure the  continued  services of
Executive as an employee of the Company, and to provide for certain compensation
and benefit  arrangements for Executive in the event of Executive's  termination
of  employment  under certain  circumstances,  and Executive is willing to enter
into this Agreement and perform such services.

                              TERMS AND CONDITIONS

         In  consideration  of the  respective  covenants and  agreements of the
parties contained in this Agreement, the parties agree as follows:

         1. Employment Services.  The Company hereby agrees to engage Executive,
and Executive  hereby agrees to perform  services for the Company,  on the terms
and conditions  set forth in this  Agreement.  During the Employment  Period (as
defined below),  the Company and Executive agree that Executive will serve as an
executive  officer of the  Company in the  position of Vice  President,  Natural
Products Chemistry with the duties,  responsibilities and authority as set forth
on Schedule A, or will have such other  executive title and such other executive
duties,  responsibilities  and  authority as Executive and the Company may agree
upon from time to time,  and will  perform  such  services of an  executive  and
administrative  character to the Company and its present or future  Subsidiaries
consistent  with the duties of the Company's other  executive  officers,  as the
Company's  Board of  Directors  (the  "Board") may from time to time direct (the
"Employment  Services") or the Bylaws of the Company may provide. The Employment
Services  shall commence upon the Effective Date of this Agreement and terminate
as provided in Paragraph 6 (the "Employment Period").

         2.       Performance.

                  (a) Executive shall report to the Chief Executive  Officer (or
person  acting in a  similar  capacity  if the  Company  has no Chief  Executive
Officer), and Executive shall devote his best efforts and his full business time
and  attention  (except for permitted  vacation  periods) to the business of the
Company and its Subsidiaries;  provided,  however,  that upon prior agreement by
the  Chief  Executive  Officer,  and  subject  to the  terms of this  Agreement,
Executive  may  engage  in  independent  activities  in areas  unrelated  to the
Company's business or the Company's actual or demonstrably anticipated business;
and provided,  further,  that no such  independent  activities  shall materially
detract from the  essentially  full time commitment of Executive to the business
and  affairs  of  the   Company.   Executive   shall   perform  his  duties  and
responsibilities  to the  best  of his  abilities  in a  diligent,  trustworthy,
businesslike and professional manner.



<PAGE>



                  (b)  Unless  the  Company  and  Executive   otherwise   agree,
Executive  shall  perform the  Employment  Services at the  Company's  executive
offices and traveling on business as Executive and the Company shall  reasonably
deem necessary.

         3.       Compensation.

                  (a)  During  the  Employment  Period,  the  Company  will  pay
Executive for the  Employment  Services a base salary (the "Base Salary") at the
annual  rate  of  $116,600  or such  other  increased  rate as the  compensation
committee of the Board or Board committee  performing  equivalent functions (the
"Compensation  Committee") (or if the Board has no Compensation Committee at the
time, then the Board) may designate from time to time, such salary to be paid at
such periods as salary is paid to other executive  officers of the Company.  The
Compensation  Committee  (or the Board,  if  applicable)  shall  review the Base
Salary of the Executive at least  annually on the  anniversary  of the Effective
Date and may, in its sole  discretion,  increase  (but not  decrease)  such Base
Salary  from time to time.  Payment of the Base  Salary  shall be subject to the
customary withholding tax and other employment taxes as required with respect to
compensation paid by a corporation to an employee.

                  (b) Executive  may receive an annual bonus in such amount,  if
any,  as  the  Compensation  Committee  (or  if the  Board  has no  Compensation
Committee  at the  time,  then  the  Board),  in its  discretion,  may  award to
Executive, based upon Executive's and the Company's performance during each year
of the Employment  Period,  provided,  however that each annual bonus payable to
Executive during the Employment Period shall not be less than the greater of (i)
$15,000 or (ii) the amount of the highest annual bonus paid to Executive for the
three most recent fiscal years of the Company.

                  (c) The  Executive  shall be  entitled  to receive  such stock
options  during the  Employment  Period as  determined  from time to time by the
Compensation  Committee  (or if the Board has no  Compensation  Committee at the
time, then the Board).

         4.  Reimbursement  for Expenses.  The Company shall promptly  reimburse
Executive  for all  reasonable  out-of-pocket  expenses  incurred  by him in the
course of performing his duties under this  Agreement,  subject to the Company's
reasonable  requirements  with respect to reporting  and  documentation  of such
expenses.

         5. Benefits. Executive shall be entitled to all fringe benefits offered
by the Company  and to  participate  in all of the  Company's  employee  benefit
programs both on the same basis as available to  executives of the Company,  and
shall be  entitled  to such  other  benefits  as may  from  time to time be made
available to  Executive.  The Company  shall use  commercially  reasonable  best
efforts to obtain and keep directors' and officers' liability insurance coverage
in effect in an amount equivalent to that of a well-insured,  similarly-situated
company;  provided,  however, that the failure to obtain and keep such insurance
in effect after the Company has  exercised  such  commercially  reasonable  best
efforts shall not be a breach of the Company's obligations under this Agreement.
During the Employment Period,  Executive shall be entitled to four weeks of paid
vacation during each year of the Employment Period and may carry over up to four
weeks of vacation from one year to the next succeeding year only.

                                        2

<PAGE>



         6.       Term and Termination.

                  (a)  Except  as  otherwise  provided  in this  Agreement,  the
Employment Period shall terminate upon the earlier of:

     (i) three  years from the  Effective  Date  hereof  (the  "Initial  Term");
provided,  however,  that the  Employment  Period  shall be extended by one year
after  the  Initial  Term and each year  thereafter  on the  anniversary  of the
Effective Date of this Agreement (each such extension,  a "Renewal Term") unless
either Executive or the Board shall have given written notice to the other party
no later than 180 days prior to the  commencement  of any Renewal Term of his or
its  desire  to  terminate  the  Employment  Period  on the  date  prior  to the
commencement of such Renewal Term;

     (ii) Executive's  incapacity or permanent  disability (which in either case
shall be deemed to occur only in the event  Executive  is unable to perform  the
Employment Services for 180 days in any 12-month period) or death;

     (iii)  termination by Executive  voluntarily or for Good Reason (as defined
below);

     (iv) termination by the Company with or without Cause (as defined below).

                  (b) If the Employment  Period is terminated (i) by the Company
without  Cause or (ii) by Executive  for Good Reason,  then  Executive  shall be
entitled to receive,  so long as Executive  has not breached the  provisions  of
Paragraphs  9, 10,  12, 13,  14, or 16 hereof in a manner  that could  adversely
affect  the  Company,  his  Base  Salary  in cash at the  periods  set  forth in
Paragraph 3, at a rate equal to the then  applicable rate set forth in Paragraph
3 for a period equal to the greater of (x) the  remainder of the Initial Term or
the then current  Renewal  Term, as  applicable,  or (y) one year plus in either
case (I) the greater of (A) the most recent  annual  bonus,  if any,  awarded to
Executive  pursuant to  Paragraph  3(b) during the  Company's  fiscal year of or
during the Company's  fiscal year prior to termination,  as the case may be, (B)
the  average  amount  of the last  three  annual  bonuses,  if any,  awarded  to
Executive  pursuant to  Paragraph  3(b) prior to  termination,  or (C)  $15,000,
multiplied by in any case not less than the number of years for which  Executive
is entitled to receive his Base Salary pursuant to this Paragraph 6(b) (prorated
for any partial  year) (such bonus amounts to be paid pro rata over the term for
which  Executive  is  entitled  to  receive  his Base  Salary  pursuant  to this
Paragraph  6(b));  plus (II) at Executive's  election,  medical,  dental and any
other health  insurance,  life  insurance,  accidental  death and  dismemberment
insurance  and  disability  protection  no less  favorable to Executive  and his
dependents  covered thereby  (including that Executive shall remain obligated to
continue  to pay any  costs or  expenses  which  Executive  would  otherwise  be
obligated  to pay  pursuant  to such  insurance  or other  protections  provided
pursuant to Paragraph 5 as in existence on the date of such  termination)  until
the first to occur of (i) the date of Executive's  re-employment  and subsequent
opportunity  to  participate  in any health  insurance  program with  comparable
coverage provided by such new employer,  including without limitation,  coverage
with respect to any  pre-existing  conditions or (ii) eighteen months after such
termination date.

                                        3

<PAGE>



                  (c) If a Change of  Control  (as  defined  below)  occurs  and
Executive  is  thereafter  offered and  accepts  continued  employment  with the
Company (or its  successor),  and either (i) he is still employed by the Company
on the  first  calendar  anniversary  of the  Change  of  Control,  or (ii)  his
employment  with the Company is  terminated  by the Company  without Cause or he
terminates  his  employment  for Good Reason  during such one year  period,  the
Company shall pay Executive, in addition to any other amounts payable hereunder,
a "stay bonus"  equal to one year's then current Base Salary.  Such "stay bonus"
shall be paid in a cash lump sum to Executive  within twenty (20) days following
the earlier of (i) the first anniversary of the date of the Change of Control or
(ii) the date of his termination of employment with the Company. For purposes of
this  Agreement,  a  "Change  of  Control"  means  the  happening  of any of the
following:  (i) the merger or  consolidation of the Company into a new surviving
company  in  which  the  holders  of  the  Company's  voting  securities  (on  a
fully-diluted  basis)  immediately prior to the merger or consolidation own less
than a majority  of the  ordinary  voting  power to elect  directors  of the new
surviving  company  (on a fully  diluted  basis),  or (ii) when any  "person" as
defined in Section 3(a)(9) of the Securities Exchange Act of 1934 (the "34 Act")
and as used in Sections 13(d) and 14(d) thereof,  including a "group" as defined
in Section 13(d) of the 34 Act but  excluding the Company and any  Subsidiary or
any  employee  benefit  plan  sponsored  or  maintained  by the  Company  or any
Subsidiary  (including  a trustee of such plan acting as  trustee),  directly or
indirectly,  becomes the "beneficial  owner" (as defined in Rule 13d-3 under the
34 Act, as amended from time to time), of securities of the Company representing
25% or more of the  combined  voting  power of the  Company's  then  outstanding
securities.

                  (d)  Except  as  provided  in  Paragraphs  6(b) or  (c),  upon
termination of the  Employment  Period,  Executive  shall be entitled to receive
only  (i)  accrued  but  unpaid  salary  and  bonus  through  the  date  of such
termination and (ii) unpaid salary with respect to any vacation days accrued but
not taken as of the date of such termination.

                  (e) For purposes of this Agreement, "Cause" shall mean (i) the
conviction (or plea of nolo  contendere) of a felony or a crime  involving moral
turpitude or the  commission of any other act which has an adverse effect on the
Company and which involves  dishonesty,  disloyalty or fraud with respect to the
Company or any of its Subsidiaries,  (ii) conduct bringing the Company or any of
its  Subsidiaries  into  substantial  public  disgrace or disrepute,  including,
without limitation, such conduct resulting from repeated acts of alcohol or drug
abuse, (iii) continued failure by Executive to substantially  perform his duties
as reasonably  directed by the Board for a period of 15 days after the Board has
made a demand for  substantial  performance  which  specifically  identifies the
manner  in  which  the  Board  believes  that  Executive  has not  substantially
performed his duties,  or (iv) gross  negligence or misconduct not in good faith
with  respect  to the  Company  or any of its  Subsidiaries,  or (v)  any  other
material  breach  of this  Agreement  which is not cured  within  15 days  after
Executive's receipt of written notice thereof.

                  (f)  For  purposes  of  this  Agreement,  termination  of  the
Employment  Period by Executive  for "Good  Reason"  shall mean  termination  by
Executive  (i) within 90 days after  Executive  has been  assigned,  without his
consent,  to any duties  substantially  inconsistent with his position,  duties,
responsibilities  or status with the Company as  contemplated  in Paragraph 1 of
this Agreement;  (ii) following a Change of Control, upon failure of the Company
to pay  Executive  an annual  bonus equal to the  average  amount of such annual
bonus paid to Executive during the three

                                        4

<PAGE>



fiscal years of the Company  immediately  preceding the year in which the Change
of Control occurs;  (iii) following a reduction of Executive's Base Salary after
a Change of Control;  (iv) if  Executive  is required to  regularly  perform the
duties of his employment more than 50 miles from Boulder,  Colorado; or (v) upon
a material  breach of this Agreement by the Company which is not cured within 30
days after the Company's  receipt of written  notice  thereof.  Executive  shall
provide  written  notice to the  Company of any and all grounds  that  Executive
alleges  constitute  "Good  Reason"  and the  Company  shall  have 30 days after
receipt  of such  written  notice  to cure any such  alleged  grounds  for "Good
Reason".  If,  following the expiration of such 30 day period,  Executive  still
believes  that "Good  Reason"  exists for his  termination  of  Employment,  the
provisions of Paragraph 7 shall apply.

                  (g) Promptly  (but in any event within 20 days)  following any
termination  of the  Employment  Period,  and as of that date,  the Company will
notify  Executive of the itemized and  aggregate  cash value of the payments and
benefits,  as determined  under  Section 280G of the Internal  Revenue Code (the
"Code"),  received  or to be  received  by  Executive  in  connection  with  the
termination of his  employment  (whether  payable  pursuant to the terms of this
Agreement or otherwise). At the same time, the Company shall advise Executive of
the portion of such payments or benefits  which  constitute  parachute  payments
within the meaning of the Code and which may subject Executive to the payment of
excise  taxes  pursuant to Section  4999 and the  expected  amount of such taxes
(such  payments  or  benefits  being  hereinafter   referred  to  as  "Parachute
Payments").

                  (h)  Notwithstanding  the provisions of Paragraph 6(b) hereof,
if all or any portion of the payments or benefits  provided under Paragraph 6(b)
either alone or together  with other  payments or benefits  which  Executive has
received  or is  then  entitled  to  receive  from  the  Company  and any of its
Subsidiaries  would  constitute  Parachute  Payments,  such payments or benefits
provided  to  Executive  under  Paragraph  6(b)  shall be  reduced to the extent
necessary so that no portion  thereof shall be subject to the excise tax imposed
by  Section  4999 of the  Code;  but  only  if,  by  reason  of such  reduction,
Executive's net after tax benefit shall exceed the net after tax benefit if such
reduction were not made.  "Net after tax benefit" for purposes of this Paragraph
6(h)  shall mean the sum of (i) the total  amount  payable  to  Executive  under
Paragraphs 6(b) and (c) hereof,  plus (ii) all other payments and benefits which
Executive  has received or is then  entitled to receive from the Company and any
of its subsidiaries  that would constitute a Parachute  Payment,  less (iii) the
amount of federal  income taxes payable with respect to the payment and benefits
described in (i) and (ii) above  calculated at the maximum  marginal  income tax
rate  for  each  year in  which  such  payments  and  benefits  shall be paid to
Executive  (based upon the rate in effect for such year as set forth in the Code
at the  Termination  Date),  less (iv) the amount of excise  taxes  imposed with
respect to the payments and benefits  described in (i) and (ii) above by Section
4999 of the Code.

                  For purposes of this Paragraph 6(h),  Executive's base amount,
the present  value of the Parachute  Payments,  the amount of the excise tax and
all other appropriate  matters shall be determined by the Company's  independent
auditors in accordance with the principles of Section 280G of the Code and based
upon the advice of tax counsel selected by the Company,  which tax counsel shall
be reasonably satisfactory to Executive.

         7.  Notice of Certain  Terminations.  In the event that  either (i) the
Company shall  terminate  Executive for Cause or (ii) Executive  shall terminate
for Good Reason,  then any such  termination  shall be  communicated  by written
notice to the other party hereto. Any such notice shall

                                        5

<PAGE>



specify(x) the effective date of  termination of the Employment  Period,  which,
except as otherwise  provided in Paragraph 6(f),  shall not be more than 30 days
after the date the notice is delivered (the "Termination Effective Date" and (y)
in reasonable detail the facts and circumstances underlying a determination that
the  termination is for Cause or for Good Reason,  as the case may be. If within
15 days after any notice of termination of Executive for Cause by the Company is
given,  or if  within 15 days  after  the  Company's  30 day cure  period  under
Paragraph 6(f) has expired,  the party  receiving such notice notifies the other
party that a good faith dispute exists  concerning the  characterization  of the
termination,  the  Termination  Effective  Date  shall be the date on which such
dispute is finally  resolved  either by written  agreement  of the parties or by
binding arbitration  conducted pursuant to the rules of the American Arbitration
Association. Notwithstanding the pendency of any such dispute, the Company shall
continue Executive and his dependents as participants in all medical, dental and
any other health  insurance and similar benefit plans of the Company in which he
and they were  participating  when the notice  giving  rise to the  dispute  was
given,  until the  dispute is finally  resolved.  Benefits  provided  under this
Paragraph 7 are in addition to all other  amounts due under this  Agreement  and
shall not be  offset  against,  or reduce  any other  amounts  due  under,  this
Agreement.

         8.  Insurance.  The Company  may, at its  election and for its benefit,
insure Executive  against  accidental  death, and Executive shall submit to such
physical  examination  and  supply  such  information  as  may  be  required  in
connection therewith.

         9.       Non-disclosure of Confidential Information.

                  (a) Unless  Executive  first secures  written consent from the
Company  pursuant to  procedures  implemented  by Company after the date hereof,
Executive  shall not disclose or use at any time,  either during the  Employment
Period or thereafter,  any Confidential Information (as defined in Paragraph 17)
except to the extent Executive  reasonably  believes is necessary to disclose or
use  such  Confidential  Information  in  performing  the  Employment  Services.
Executive  further agrees that Executive will use  Executive's  commercial  best
efforts  to  safeguard  the  Confidential  Information  and  protect  it against
disclosure,  misuse, espionage,  loss and theft, including,  without limitation,
causing  recipients of  Confidential  Information  to enter into  non-disclosure
agreements with the Company.  Subject to the provisions of Paragraphs 10 and 13,
nothing herein shall be construed to prevent  Executive  from using  Executive's
general  knowledge  and  skill  after  termination  of this  Agreement,  whether
Executive  acquired  such  knowledge  or skill  before or during the  Employment
Period.

                  (b) In the event the Company has entered into  confidentiality
agreements with third parties (not including  Company  employees)  which contain
provisions  different from those set forth in this Agreement,  Executive agrees,
in  addition  to the  provisions  of  Paragraph  9(a),  to comply  with any such
different provisions of which Executive is notified by the Company.

         10.  Company  Ownership  of  Intellectual  Property.  Executive  hereby
assigns to the Company all right,  title and interest in and to all Intellectual
Property (as defined in  Paragraph  17)  contributed  to or conceived or made by
Executive during the Employment Period and prior to the Employment Period during
the period  Executive  was  employed by or engaged in  research  or  development
activities for or with the Company or its predecessors  and affiliates  (whether
alone or jointly  with others) to the extent such  Intellectual  Property is not
owned by the Company as a matter

                                        6

<PAGE>



of law.  Executive  shall  promptly  and fully  communicate  to the  Company all
Intellectual  Property conceived,  contributed to or made by Executive and shall
cooperate  with  the  Company  to  protect  the  Company's   interests  in  such
Intellectual  Property including,  without limitation,  providing  assistance in
securing patent protection and copyright registrations and signing all documents
reasonably  requested  by the  Company,  even if such  request  occurs after the
Employment  Period.  The Company shall pay  Executive's  reasonable  expenses of
cooperating  with the Company in  protecting  the  Company's  interests  in such
Intellectual  Property unless the subject matter of the requested cooperation is
related  to  actions  taken or failed  to be taken by  Executive  wrongfully  or
otherwise not in good faith.

         11. Executive's  Rights.  Paragraph 10 of this Agreement does not apply
to an invention  for which no  equipment,  supplies,  facilities or trade secret
information  of the  Company  was used  and  which  was  developed  entirely  on
Executive's  own time,  unless (a) the invention  relates (i) to the business of
the  Company,  or (ii)  to the  Company's  actual  or  demonstrably  anticipated
material  research or  development,  or (b) the invention  results from any work
performed by Executive for the Company.

         12. Return of Materials.  Upon termination of the Employment Period, or
at any time  reasonably  requested  by the  Company,  Executive  shall  promptly
deliver to the Company all copies of  Confidential  Information  in  Executive's
possession  and control,  including  written  records,  manuals,  lab notebooks,
customer and supplier lists and all other materials  containing any Confidential
Information.   If  the  Company   requests,   Executive  shall  provide  written
confirmation  that  Executive  has returned all such  materials.  Subject to the
provisions  of this  Agreement,  including,  without  limitation,  Paragraph 11,
notwithstanding  anything in this Agreement to the contrary, upon termination of
the  Employment  Period,  the Company,  at Executive's  request,  shall promptly
return to Executive any  equipment or other  materials  owned by Executive  then
being used by or then in the possession of the Company.

         13. Non-Competition.  Executive acknowledges and agrees that during the
Employment  Period and for a period of five years  thereafter (the  "Non-compete
Period"),  Executive will not, without the prior written consent of the Company,
directly or indirectly,  provide products or services  substantially  similar to
the  Employment  Services to any  business or entity that  provides or offers or
demonstrably  plans to provide or offer,  products or services  that (i) are the
same as or  substantially  similar to the  products or services  provided by the
Company at any time during the Employment  Period,  (ii) relate to the Company's
Intellectual  Property (whether the Company acquired such Intellectual  Property
pursuant to this Agreement or otherwise),  or (iii) relate to any subject matter
of the  Company's  actual or  demonstrably  anticipated  material  research  and
development during the Employment Period,  including without limitation,  taxol,
taxanes  and any other  compounds,  within  any  geographical  area in which the
Company or any of its  subsidiaries  provide or plan to provide such products or
services.

         14. Non-Solicitation. Executive acknowledges and agrees that during the
Non-compete Period Executive will not (a) solicit,  induce or attempt to induce,
directly or  indirectly,  any employee of the Company to leave the employment of
the Company to work for Executive or for any other person,  firm or  corporation
or (b) hire any employee of the Company.


                                        7

<PAGE>



         15. Acknowledgment of Reasonableness. Executive acknowledges and agrees
that the  limitations  set forth in  Paragraphs  13 and 14 are  reasonable  with
respect to scope, duration and geographic area and are properly required for the
protection of the legitimate business interest of the Company.

         16. Further Assistance.  During the Non-compete Period,  Executive will
not make any disclosure or other  communication to any person,  issue any public
statements or otherwise cause to be disclosed any information which is designed,
intended or might reasonably be anticipated to discourage any persons from doing
business with the Company or otherwise have a negative  impact or adverse effect
on the Company,  except to the extent such disclosure is required by law. During
the Non-compete Period,  Executive will provide assistance  reasonably requested
by the  Company  in  connection  with  actions  taken by  Executive  during  the
Employment  Period,  including but not limited to assistance in connection  with
any lawsuits or other claims against the Company  arising from events during the
Employment  Period,  provided  that the Company shall  reimburse all  reasonable
expenses  (including  without  limitation,  reasonable loss of compensation from
other sources resulting from such assistance during normal business hours).

         17.      Certain Definitions.

                  "Affiliate"  means  a  person  that  directly,  or  indirectly
through one or more intermediaries,  controls,  or is controlled by, or is under
common control with, the person specified.

                  "Confidential  Information" means all information  (whether or
not specifically labeled or identified as confidential),  in any form or medium,
that is disclosed to, or developed or learned by Executive during the Employment
Period  and prior to the  Employment  Period  during the  period  Executive  was
employed  by or engaged in research or  development  activities  for or with the
Company or its  predecessors  and  affiliates  or that relates to the  business,
products,  services,  customers,  research or  development  of the Company,  its
Subsidiaries,  its  Affiliates,  or third  parties  with whom the  Company,  its
Subsidiaries  or its  Affiliates  does  business or from whom the Company or its
Affiliates receives information.  Confidential Information shall not include any
information that (i) has become publicly known through no wrongful act or breach
of any  obligation  of  confidentiality,  as  evidenced  by  written  records or
documents;  or (ii) was rightfully  received by Executive on a  non-confidential
basis  from a third  party  (provided  that  such  third  party is not  known to
Executive to be bound by a confidentiality agreement with the Company or another
party), as evidenced by written records or documents.

                  "Independent  Third  Party"  means  any  person,  including  a
"group" as defined in Section  13(d)(3) of the Securities  Exchange Act of 1934,
as amended, and the rules and regulations thereunder,  who, immediately prior to
the  contemplated  transaction,  does not own in excess  of 5% of the  Company's
Common Stock on a fully-diluted basis, who is not controlling,  controlled by or
under common  control with any such 5% owner of the  Company's  Common Stock and
who is not the spouse or descendent  (by birth or adoption) of any such 5% owner
of the Company's Common Stock.

                  "Intellectual  Property"  means any idea,  invention,  design,
development,  device, method or process (whether or not patentable or reduced to
practice or including Confidential

                                        8

<PAGE>



Information) and all related patents and patent applications,  any copyrightable
work or mask work (whether or not including  Confidential  Information)  and all
related   registrations  and  applications  for  registration,   and  all  other
proprietary rights.

                  "Subsidiaries"  means any  corporation of which the securities
having a majority of the voting power in electing  directors are, at the time of
determination,   owned  by  the  Company,   directly  or  through  one  of  more
Subsidiaries.

         18. Executive Representations. Executive hereby represents and warrants
to the  Company  that  (a)  the  execution,  delivery  and  performance  of this
Agreement by Executive does not and will not conflict with,  breach,  violate or
cause a default under any contract,  agreement,  instrument,  order, judgment or
decree to which  Executive is a party or by which he is bound,  and (b) upon the
execution and delivery of this Agreement by the Company, this Agreement shall be
the valid and binding  obligation of Executive,  enforceable in accordance  with
its terms.

         19. Company Representations. The Company hereby represents and warrants
to Executive that (a) the execution,  delivery and performance of this Agreement
by the Company does not and will not conflict with,  breach,  violate or cause a
default under any contract, agreement,  instrument, order, judgment or decree to
which Company is a party or by which it is bound, and (b) upon the execution and
delivery of this Agreement by Executive,  this Agreement  shall be the valid and
binding obligation of the Company, enforceable in accordance with its terms.

         20.  Severability and Modification.  If any provision of this Agreement
shall be held or declared to be illegal, invalid or unenforceable, such illegal,
invalid or unenforceable  provision shall not affect any other provision of this
Agreement,  and the remainder of this Agreement shall continue in full force and
effect as though such provision had not been contained in this Agreement. If the
scope of any  provision  in this  Agreement  is found to be too  broad to permit
enforcement of such provision to its full extent, Executive consents to judicial
modification of such provision and  enforcement to the maximum extent  permitted
by law.

         21. Notices. Except as otherwise expressly set forth in this Agreement,
all notices, requests and other communications to be given or delivered under or
by reason of the provisions of this  Agreement  shall be in writing and shall be
given (and, except as otherwise  provided in this Agreement,  shall be deemed to
have  been  duly  given if so  given)  when  delivered  if given in person or by
telegram,  three days after being mailed by first class  registered or certified
mail,  return receipt  requested,  postage prepaid,  or one day after being sent
prepaid  via  reputable  overnight  courier  to the  parties  at  the  following
addresses  (or such  other  address  as shall be  furnished  in  writing by like
notice;  provided,  however, that notice of change of address shall be effective
only upon receipt):

Notices to Executive
         James D. McChesney
         c/o NaPro BioTherapeutics, Inc.
         6304 Spine Road, Unit A
         Boulder, Colorado  80301


                                        9

<PAGE>



Notices to Company
         NaPro BioTherapeutics,
         6304 Spine Road, Unit A
         Boulder, Colorado 80301

         Attn.:   Patricia A. Pilia, Ph.D.
                  Executive Vice President

         with a copy to:
         Holme Roberts & Owen
         1700 Lincoln, Suite 4100
         Denver, CO 80203

         Attn.:  Francis Wheeler

     22. Entire Agreement.  This Agreement contains the entire agreement between
the  parties  with  respect to the  subject  matter  hereof and  supersedes  any
previous  understandings or agreements,  whether written or oral, regarding such
subject matter.

     23. Governing Law. All questions concerning the construction,  validity and
interpretations  of this Agreement will be governed by the internal law, and not
the law of conflicts, of the State of Colorado.

     24.  Survival.  Paragraphs  6, 9, 10,  11,  12, 13, 14 and 16 and any other
provision of this Agreement which by its terms could survive  termination of the
Employment  Period shall survive and continue in full force in  accordance  with
their terms notwithstanding any termination of the Employment Period.

     25. Counterparts.  This Agreement may be executed in separate counterparts,
each of which is  deemed  to be an  original  and all of  which  taken  together
constitute one and the same agreement.

     26. Successors and Assigns. This Agreement is intended to bind and inure to
the benefit of and be enforceable by Executive, the Company and their respective
successors and assigns;  provided that in no event shall Executive's obligations
under this  Agreement  be  delegated  or  transferred  by  Executive,  nor shall
Executive's  rights be subject to  encumbrance  or to the claims of  Executive's
creditors.  This  Agreement  is for the sole  benefit of the parties  hereto and
shall not create any rights in third  parties other than  Executive's  spouse or
beneficiary as expressly set forth herein.

     27. Remedies.  Except as otherwise provided in this Agreement,  (i) each of
the parties to this  Agreement will be entitled to enforce its rights under this
Agreement  specifically,  to  recover  damages  by reason  of any  breach of any
provision of this  Agreement and to exercise all other rights to which it may be
entitled and (ii) disputes under this Agreement not finally  resolved in writing
by the parties  within  sixty days after one party gives notice in good faith to
the other party that a bona fide dispute  exists  shall be resolved  pursuant to
binding arbitration  conducted in Denver,  Colorado in accordance with the rules
of the American Arbitration Association. The prevailing party in any

                                       10

<PAGE>



such  arbitration  shall be entitled to have its costs and  expenses  (including
reasonable  attorney's fees and expenses)  relating to such  arbitration paid by
the other party if the  arbitrator(s)  conducting such arbitration so determine.
Notwithstanding  the  foregoing,  the parties agree and  acknowledge  that money
damages  may not be an  adequate  remedy  for breach of the  provisions  of this
Agreement  and that any party may in its sole  discretion  apply to any court of
law  or  equity  of  competent  jurisdiction  for  specific  performance  and/or
injunctive  relief  in  order  to  enforce  or  prevent  any  violations  of the
provisions of this Agreement. The prevailing party in any suit shall be entitled
to recover reasonable attorneys fees and costs from the other party.

     28.  Modifications  and  Waivers.  No provision  of this  Agreement  may be
modified,  altered or amended except by an instrument in writing executed by the
parties  hereto.  No waiver by either  party  hereto of any  breach by the other
party hereto of any term or provision of this  Agreement to be performed by such
other  party  shall  be  deemed a  waiver  of  similar  or  dissimilar  terms or
provisions at the time or at any prior or subsequent time.

     29. Headings.  The headings  contained herein are solely for the purpose of
reference,  are not part of this  Agreement  and shall not in any way affect the
meaning or interpretation of this Agreement.

     30. Notification of Subsequent Employer.  Executive agrees that the Company
may present a copy of this Agreement to any third party.

     31.  UNDERSTAND  AGREEMENT.  EXECUTIVE  REPRESENTS  AND  WARRANTS  THAT (a)
EXECUTIVE HAS READ AND UNDERSTOOD  EACH AND EVERY  PROVISION OF THIS  AGREEMENT,
(b)  EXECUTIVE  HAS HAD THE  OPPORTUNITY  TO OBTAIN ADVICE FROM LEGAL COUNSEL OF
EXECUTIVE'S  CHOICE,  OTHER THAN COUNSEL TO THE COMPANY (WHO IS NOT REPRESENTING
THE EXECUTIVE),  IN ORDER TO INTERPRET ANY AND ALL PROVISIONS OF THIS AGREEMENT,
(c) EXECUTIVE HAS HAD THE  OPPORTUNITY TO ASK THE COMPANY  QUESTIONS  ABOUT THIS
AGREEMENT  AND ANY OF SUCH  QUESTIONS  EXECUTIVE HAS ASKED HAVE BEEN ANSWERED TO
EXECUTIVE'S  SATISFACTION,  AND  (d)  EXECUTIVE  HAS  BEEN  GIVEN A COPY OF THIS
AGREEMENT.

         IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
duly executed on the day and year first above written.

                       EXECUTIVE

                                 /s/ James D. McChesney
                       -----------------------------------
                                James D. McChesney




                       NAPRO BIOTHERAPEUTICS, INC.


                       By:      /s/ Gordon H. Link, Jr.
                                Gordon H. Link, Jr.
                                Vice President, Finance and
                                Chief Financial Officer



                                       11

<PAGE>


<TABLE> <S> <C>

<ARTICLE> 5
<MULTIPLIER> 1,000 
        
<S>                                                     <C>         
<PERIOD-TYPE>                                           9-MOS
<FISCAL-YEAR-END>                                 DEC-31-1998
<PERIOD-END>                                     SEP-30-1998
<CASH>                                                  9,135
<SECURITIES>                                                0
<RECEIVABLES>                                             429
<ALLOWANCES>                                                0
<INVENTORY>                                             4,171
<CURRENT-ASSETS>                                       15,810
<PP&E>                                                 18,037
<DEPRECIATION>                                          4,816
<TOTAL-ASSETS>                                         30,627
<CURRENT-LIABILITIES>                                   6,173
<BONDS>                                                 6,022
                                       0
                                             4,025
<COMMON>                                                  125
<OTHER-SE>                                             13,659
<TOTAL-LIABILITY-AND-EQUITY>                           30,627
<SALES>                                                 3,721
<TOTAL-REVENUES>                                        3,721
<CGS>                                                       0
<TOTAL-COSTS>                                          12,488
<OTHER-EXPENSES>                                            0
<LOSS-PROVISION>                                            0
<INTEREST-EXPENSE>                                        821
<INCOME-PRETAX>                                         1,595
<INCOME-TAX>                                                0
<INCOME-CONTINUING>                                     1,595
<DISCONTINUED>                                              0
<EXTRAORDINARY>                                             0
<CHANGES>                                                   0
<NET-INCOME>                                            1,595
<EPS-PRIMARY>                                             .10
<EPS-DILUTED>                                             .09
        


</TABLE>


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