NAPRO BIOTHERAPEUTICS INC
8-K, 1999-01-27
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549




                                    FORM 8-K

                                 CURRENT REPORT


     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934



        Date of report (Date of earliest event reported): January 27, 1999

                           NAPRO BIOTHERAPEUTICS, INC.
               (Exact Name of Registrant as Specified in Charter)


 Delaware                         0-243201                 84-1187753
(State or Other Jurisdiction     (Commission File Number) (I.R.S. Employer
of Incorporation)                                         Identification Number)


                             6304 Spine Road, Unit A
                             Boulder, Colorado                   80301
                   (Address of Principal Executive Offices)   (Zip code)


       Registrant's telephone number, including area code: (303) 530-3891

<PAGE>

Item 5.       Other Events

     On December 4, 1998, the Company  entered into letter  agreements with each
of the holders of certain  Warrants to purchase common stock of the Company (the
"Warrants") and warrants to purchase Warrants (the "Other Warrants"),  modifying
the terms of the  Warrants  and the Other  Warrants.  The Warrants and the Other
Warrants  were  issued  to the  underwriters  of the  Company's  initial  public
offering in 1994.  Pursuant to these letter agreements,  the number of shares of
Common Stock  underlying the Warrants and Other Warrants was reduced by 50%, the
exercise  price of the Warrants was reduced from $7.50 to $1.90 and the exercise
price of the Other  Warrants was reduced from $.30 to $.15. As a result of these
changes,  the number of shares of Common Stock  underlying  the Warrants and the
Other Warrants was reduced from 331,008 to 165,504.


Item 7.       Financial Statements, Pro Forma Financial Information and Exhibits

     (c)      Exhibits

Exhibit No.                 Exhibit Description

4.1                         Form of  Letter  Agreements, dated as of December 3,
                            1998,  by and between the Registrant and each holder
                            of Warrants and Other Warrants.


                                   SIGNATURES

     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.


                           NAPRO BIOTHERAPEUTICS, INC.



                           By: \s\ Gordon H. Link, Jr.
                               Gordon H. Link, Jr.
                               Chief Financial Officer

Date:  January 27, 1999

<PAGE>




                  [letterhead of NaPro Biotherapeutics, Inc.]

                             6304 Spine Road, Unit A
                             Boulder, Colorado 80301
                               Tel: (303) 530-3891
                               Fax: (303) 530-1296



98 DEC 3



VIA FACSIMILIE

________________
________________
________________
________________

Dear __________,

     As you are  aware,  in March  1998  NaPro  made an offer to the  holders of
certain  warrants (the  "Warrants")  to purchase NaPro Common Stock and warrants
(the "Other Warrants") to purchase Warrants. The Warrants and the Other Warrants
had been issued by NaPro to Whale Securities in conjunction with NaPro's initial
public  offering.  The offer,  in effect,  would have reduced the $7.50 exercise
price of the Warrants to $1.90 in exchange for a 50%  reduction in the number of
shares that could be purchased  upon  exercise.  No holders of Warrants or Other
Warrants accepted the offer in March.

     In response to your  request,  NaPro has decided to re-extend to holders of
Warrants  and Other  Warrants  the offer  originally  made in March on following
terms.

     Any holder of Warrants or Other Warrants accepting the offer thereby agrees
     to the  amendment  of the  Warrants  to reduce  the  exercise  price of the
     Warrants to $1.90 per share and to a 50%  reduction in the number of shares
     that may be purchased  upon exercise.  The number of shares  underlying the
     Other  Warrants  would also be reduced  by 50% and the  aggregate  exercise
     price of the Other Warrants would be reduced by half. Other principal terms
     of the Warrants and the Other  Warrants,  such as  expiration  date and the
     like, would remain unchanged.

     According to Company  records,  of the 180,000  Warrants and 180,000  Other
     Warrants  originally  issued  159,504  Warrants and 171,504 Other  Warrants
     remain  outstanding.  Full  participation  in the offer  would,  therefore,
     result  in a  reduction  in the  number of  shares  of NaPro  Common  Stock
     issuable upon exercise of all outstanding  Warrants and Other Warrants from
     331,008 to 165,504 at an exercise price of $1.90 per share, plus $0.075 per
     share relating to the Other Warrants.


<PAGE>



         

     As the foregoing  revisions to the Warrants and Other Warrants would likely
     require an amendment or supplement to the  registration  statement filed by
     NaPro  relating to the  Warrants  and the Other  Warrants,  exercise of the
     Warrants  and Other  Warrants  and  resale of  underlying  shares  would be
     prohibited until the registration  statement had been appropriately amended
     or  supplemented,  which NaPro would use its best  efforts to effect by the
     end of March 1999.

         In  considering  this  re-extended  offer,  please  note that NaPro has
publicly disclosed that it is in discussions with  pharmaceutical  companies for
the establishment of a strategic  relationship for the development and marketing
of NaPro  paclitaxel.  While  there can be no  assurance  of NaPro's  success in
establishing  any  such  strategic  relationship,   its  entering  into  such  a
relationship  or into  another  business  combination  could  have the effect of
significantly  increasing  the trading price of NaPro's  Common  Stock.  If that
price were to  increase  sufficiently,  it would not be in the  interest  of the
holders of the Warrants and the Other Warrants to accept the offer.

         The  foregoing  offer  expires at 5:00 pm (Boulder,  Colorado  time) on
Monday,  December 5, 1998.  Any holder of Warrants or Other Warrants who desires
to accept  the  offer  must  advise  NaPro in a writing  of that  acceptance  by
countersigning  this offer letter,  which  writing must be actually  received by
NaPro on or before expiration.  Facsimile acceptances are acceptable, so long as
the original signed acceptance is received by Napro promptly thereafter.

Very truly yours,


/s/ Gordon Link
Gordon Link
Vice President, Finance

                                                             Accepted and Agreed
                                                             /s/
                                                             

                                                             


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