NAPRO BIOTHERAPEUTICS INC
SC 13G, 2000-02-14
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                             SECURITIES AND EXCHANGE
                                   COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13G


                    Under the Securities Exchange Act of 1934


                           Napro Biotherapeutics Inc.
                                (Name of Issuer)


                                  Common Stock
                         (Title of Class of Securities)

                                    630795102
                                 (CUSIP Number)


                                December 31, 1999
             (Date of Event Which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

     [X]   Rule 13d-1(b)
     [ ]   Rule 13d-1(c)
     [ ]   Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


<PAGE>


CUSIP No. 630795102                   13G                    Page 2 of 16 Pages


________________________________________________________________________________
1.   NAME OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

     Royal Bank Investment Management Inc.
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [_]
________________________________________________________________________________
3.   SEC USE ONLY


________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION
     The jurisdiction of organization is Canada (federally incorporated company)


________________________________________________________________________________
              5.   SOLE VOTING POWER

                   N/A
NUMBER OF     _________________________________________________________________
SHARES        6.   SHARED VOTING POWER
BENEFICIALLY
OWNED BY EACH      1,363,500
REPORTING     _________________________________________________________________
PERSON WITH   7.   SOLE DISPOSITIVE POWER

                   N/A
              _________________________________________________________________
              8.   SHARED DISPOSITIVE POWER

                   1,363,500
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,363,500
________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]
________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     5.9%
________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*
     Foreign Investment Adviser which received SEC no-action relief to file
     on Schedule 13G as a "Qualified Institutional Investor"
________________________________________________________________________________

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


CUSIP No. 630795102                   13G                    Page 3 of 16 Pages



________________________________________________________________________________
1.   NAME OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

     RT Investment Management Holdings Inc.
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [_]
________________________________________________________________________________
3.   SEC USE ONLY


________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION
     The jurisdiction of organization is Canada (federally incorporated company)


________________________________________________________________________________
              5.   SOLE VOTING POWER

                   N/A
NUMBER OF     _________________________________________________________________
SHARES        6.   SHARED VOTING POWER
BENEFICIALLY
OWNED BY EACH      1,363,500
REPORTING     _________________________________________________________________
PERSON WITH   7.   SOLE DISPOSITIVE POWER

                   N/A
              _________________________________________________________________
              8.   SHARED DISPOSITIVE POWER

                   1,363,500
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,363,500
________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]
________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     5.9%
________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*
     Foreign Parent Holding Company which received SEC no-action relief to file
     on Schedule 13G as a "Qualified Institutional Investor"
________________________________________________________________________________

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!



<PAGE>


CUSIP No. 630795102                  13G                    Page 4 of 16 Pages



________________________________________________________________________________
1.   NAME OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

     The Royal Trust Company
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [_]
________________________________________________________________________________
3.   SEC USE ONLY


________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION
     The jurisdiction of organization is Canada (federally incorporated company)


________________________________________________________________________________
              5.   SOLE VOTING POWER

                   N/A
NUMBER OF     _________________________________________________________________
SHARES        6.   SHARED VOTING POWER
BENEFICIALLY
OWNED BY EACH      1,363,500
REPORTING     _________________________________________________________________
PERSON WITH   7.   SOLE DISPOSITIVE POWER

                   N/A
              _________________________________________________________________
              8.   SHARED DISPOSITIVE POWER

                   1,363,500
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,363,500
________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]
________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     5.9%
________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*
     Foreign Trust Company which received SEC no-action relief to file
     on Schedule 13G as a "Qualified Institutional Investor"
________________________________________________________________________________

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>


CUSIP No. 630795102                  13G                    Page 5 of 16 Pages



________________________________________________________________________________
1.   NAME OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

     Royal Mutual Funds Inc.
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [_]
________________________________________________________________________________
3.   SEC USE ONLY


________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION
     The jurisdiction of organization is Canada (federally incorporated company)


________________________________________________________________________________
              5.   SOLE VOTING POWER

                   N/A
NUMBER OF     _________________________________________________________________
SHARES        6.   SHARED VOTING POWER
BENEFICIALLY
OWNED BY EACH      1,363,500
REPORTING     _________________________________________________________________
PERSON WITH   7.   SOLE DISPOSITIVE POWER

                   N/A
              _________________________________________________________________
              8.   SHARED DISPOSITIVE POWER

                   1,363,500
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,363,500
________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]
________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     5.9%
________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*
     Foreign Investment Adviser and Mutual Fund Dealer which received SEC
     no-action relief to file on Schedule 13G as a "Qualified Institutional
     Investor"
________________________________________________________________________________

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>

CUSIP No. 630795102                  13G                    Page 6 of 16 Pages

Item 1(a). Name of Issuer:

     Napro Biotherapeutics Inc.

Item 1(b). Address of Issuer's Principal Executive Offices:

     Napro Biotherapeutics Inc.
     6304 Spine Rd
     Unit A, Boulder, CO, 80301
     (303) 530-3891

Item 2(a). Name of Person Filing:
     1.   Royal Bank Investment Management Inc. ("RBIM")
     2.   RT Investment Management Holdings Inc. ("RTIM")
     3.   The Royal Trust Company ("RT")
     4.   Royal Mutual Funds Inc. ("RMFI")

Item 2(b). Address of Principal Business Office or, if None, Residence:

     1.   Royal Bank Investment Management Inc.
          Royal Trust Tower, P.O. Box 121
          77 King Street West, Suite 3800
          Toronto, Ontario  M5K 1H1

     2.   RT Investment Management Holdings Inc.
          Royal Trust Tower, P.O. Box 97
          77 King Street West, Suite 3900
          Toronto, Ontario  M5K 1G8

     3.   The Royal Trust Company
          Royal Trust Tower, P.O. Box 7500, Station A
          77 King Street West, 6th Floor
          Toronto, Ontario M5W 1P9

     4.   The Mutual Funds Inc.
          Royal Trust Tower, P.O. Box 7500, Station A
          77 King Street West,
          Toronto, Ontario M5W 1P9

Item 2(a). Citizenship:

     Canada

Item 2(d). Title of Class of Securities:

     Common Stock


<PAGE>

Item 2(e). CUSIP Number:

     630795102




Item 3. If this statement is filed pursuant to Rules 240.13d-1(b) or
        240.13d-2(b) or (c), check whether the person filing is a:

     1.   Royal Bank Investment Management Inc. is a Foreign Investment Adviser
          which received SEC no-action relief to file on Schedule 13G as a
          Qualified Institutional Investor.

     2.   RT Investment Management Holdings Inc. is a Foreign Parent Holding
          Company which received SEC no-action relief to file on Schedule 13G as
          a Qualified Institutional Investor.

     3.   The Royal Trust Company is a Foreign Trust Company which received SEC
          no-action relief to file on Schedule 13G as a Qualified Institutional
          Investor.

     4.   Royal Mutual Funds Inc. is a Foreign Investment Adviser and Mutual
          Fund Dealer that has received SEC no-action relief to file on Schedule
          13G as a Qualified Institutional Investor.

Item 4. Ownership.

     (a)  Amount beneficially owned:

          1.   RBIM - 1,363,500

          2.   RTIM - 1,363,500

          3.   RT - 1,363,500

          4.   RMFI - 1,363,500

     (b)  Percent of class:

          1.   RBIM - 5.9%

          2.   RTIM - 5.9%

          3.   RT - 5.9%

          4.   RMFI - 5.9%

     (c)  Number of shares as to which such person has:

            (i)  Sole power to vote or to direct the vote N/A

           (ii)  Shared power to vote or to direct the vote

                 1.   RBIM - 1,363,500

                 2.   RTIM - 1,363,500

                 3.   RT - 1,363,500

                 4.   RMFI - 1,363,500

          (iii)  Sole power to dispose or to direct the disposition of N/A


<PAGE>

           (iv)  Shared power to dispose or to direct the disposition of

                 1.   RBIM - 5.9%

                 2.   RTIM - 5.9%

                 3.   RMFI - 5.9%

                 4.   RMFI - 5.9%

Item 5. Ownership of Five Percent or Less of a Class.

     If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities, check the following [ ].

Item 6. Ownership of More than Five Percent on Behalf of Another Person.

1.   Royal Bank Investment Management Inc. Accounts managed on a discretionary
     basis by Royal Bank Investment Management Holdings Inc., a wholly-owned
     subsidiary of RT Investment Management Holdings Inc., are known to have
     the right to receive or the power to direct the receipt of dividends from,
     or the proceeds from, the sale of such securities.  No such account holds
     more than 5% of the class.

2.   RT Investment Management Holdings Inc., a foreign parent holding company
     which received SEC no-action relief to file on Schedule 13G as a Qualified
     Institutional Investor, is reporting holdings over which it is deemed to be
     a beneficial owner by virtue of the fact that the holdings belong to client
     accounts managed on a discretionary basis by RT Investment Holdings Inc.'s
     subsidiary foreign investment advisers.

3.   The Royal Trust Company, a foreign Trust Company which has received SEC
     no-action relief to file on Schedule 13G as a Qualified Institutional
     Investor, is reporting holdings over which it is deemed to be a beneficial
     owner by virtue of its status as trustee and/or as principal.

4.   RMFI, a wholly-owned subsidiary of Royal Bank of Canada, is the manager
     of accounts and has delegated its investment management to Royal Bank
     Investment Management Inc. ("RBIM").  RBIM is known to have the right to
     receive or the power to direct the receipt of the dividends from, or the
     proceeds from, the sale of securities in such accounts.  No such account
     holds more than 5% of the class.

Item 7. Identification and Classification of the Subsidiary Which Acquired the
        Security Being Reported on by the Parent Holding Company.

     Please see attached Exhibit A, Disclosure Respecting Subsidiaries.

Item 8. Identification and Classification of Members of the Group.

     N/A

Item 9. Notice of Dissolution of Group.

     N/A


<PAGE>


Item 10. Certification.

     By signing below I certify that, to the best of my knowledge and belief,
the securities referred to above were acquired and are held in the ordinary
course of business and were not acquired and are not held for the purpose of and
do not have the effect of changing or influencing the control of the issuer of
such securities and were not acquired and are not held in connection with or as
a participant in any transaction having such purpose or effect.


<PAGE>




                                    SIGNATURE

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

                                                        February 11, 2000
                                                  -----------------------------
                                                             (Date)



                                                  /s/ Jennifer Lederman
                                                  -----------------------------
                                                           (Signature)



                                                  Jennifer Lederman /
                                                  Senior Vice-President,
                                                  Compliance, Royal Bank
                                                  Investment Management Inc.
                                                  -----------------------------
                                                           (Name/Title)


<PAGE>


                                    SIGNATURE

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

                                                        February 11, 2000
                                                  -----------------------------
                                                             (Date)



                                                  /s/ Jennifer Lederman
                                                  -----------------------------
                                                           (Signature)



                                                  Jennifer Lederman / Senior
                                                  Vice-President, Compliance,
                                                  RT Investment Management
                                                  Holdings Inc.
                                                  -----------------------------
                                                           (Name/Title)


<PAGE>



                                    SIGNATURE

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

                                                        February 11, 2000
                                                  -----------------------------
                                                             (Date)



                                                  /s/ Jennifer Lederman
                                                  -----------------------------
                                                           (Signature)



                                                  Jennifer Lederman/
                                                  Authorized Signing Officer
                                                  The Royal Trust Company
                                                  -----------------------------
                                                           (Name/Title)



<PAGE>



                                    SIGNATURE

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

                                                        February 11, 2000
                                                  -----------------------------
                                                             (Date)



                                                  /s/ Simon Lewis
                                                  -----------------------------
                                                           (Signature)



                                                  Simon Lewis/
                                                  President,
                                                  Royal Mutual Funds Inc.
                                                  -----------------------------
                                                           (Name/Title)



                            EXHIBIT A TO SCHEDULE 13G
                    ITEM 7 DISCLOSURE RESPECTING SUBSIDIARIES


RT Investment Management Holdings Inc, ("RTIM") is a parent holding company as
that term is defined by Rule 13d-1(b)(1)(ii)(G) of the Securities Exchange Act
of 1934 (the "Act") and is eligible to file on Schedule 13G pursuant to an SEC
no-action relief application. RTIM's aggregation holdings represent securities
that are beneficially owned by its subsidiaries which manage these securities on
behalf of their respective clients. RTIM's subsidiaries include, Royal Bank
Investment Management, RT Capital Management Inc., and RT Investment Counsel
Inc.

Royal Bank Investment Management Inc. ("RBIM") is a wholly-owned subsidiary of
RTIM. RBIM is a foreign investment adviser that has received SEC no-action
relief to file on Schedule 13G.

RT Capital Management Inc. ("RT Capital") is a wholly-owned subsidiary of RTIM.
RT Capital is a foreign investment adviser that has received SEC no-action
relief to file on Schedule 13G.

RT Investment Counsel Inc. ("RTIC") is a wholly-owned subsidiary of RTIM. RTIC
is a foreign investment adviser that has received SEC no-action relief to file
on Schedule 13G.

RTIM, RBIM, RT Capital and RTIC are federally incorporated Canadian corporations
whose business addresses are as follows:

RT Investment Management                Royal Bank Investment
Holdings Inc.                           Management Inc.
Royal Trust Tower, P.O. Box 97          Royal Trust Tower, P.O. Box 97
77 King Street West, Suite 3900         77 King Street West, Suite 3800
Toronto, Ontario                        Toronto, Ontario
M5K 1G8                                 M5K 1G8

RT Capital Management Inc.              RT Investment Counsel Inc.
Royal Trust Tower, P.O. Box 97          Royal Trust Tower, P.O. Box 97
77 King Street West, Suite 3700         77 King Street West, Suite 3900
Toronto, Ontario                        Toronto, Ontario
M5K 1G8                                 M5K 1G8






                            EXHIBIT B TO SCHEDULE 13G
                             JOINT FILING AGREEMENT


     Each of the undersigned persons hereby agrees and consents to this joint
filing of Schedule 13G on such person's behalf, pursuant to Section 13(d) and
(g) of the Securities and Exchange Act of 1934, as amended, and the rules
promulgated thereunder. Each of these persons is not responsible for the
completeness or accuracy of the information concerning the other persons making
this filing, unless such persons know or have reason to believe that such
information is inaccurate.

                                        Dated:  February 11, 2000.

                                        Royal Bank Investment Management Inc.
                                        BY: /s/ Jennifer Lederman
                                            ------------------------------------
                                            Senior Vice-President, Compliance,
                                            and Corporate Secretary


                                        RT Investment Management Holdings Inc.
                                        BY: /s/ Jennifer Lederman
                                            ------------------------------------
                                            Senior Vice-President, Compliance,
                                            and Corporate Secretary


                                        The Royal Trust Company
                                        BY: /s/ Jennifer Lederman
                                            ------------------------------------
                                            Authorized Signing Officer


                                        Royal Mutual Funds
                                        BY: /s/ Simon Lewis
                                            ------------------------------------
                                            Authorized Signing Officer




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