NAPRO BIOTHERAPEUTICS INC
NT 10-K, 2000-03-30
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                                  UNITED STATES

                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                   FORM 12b-25

                           NOTIFICATION OF LATE FILING

                         Commission File Number: 0-24320

(CHECK ONE):  /X/Form 10-K / /Form 20-F / /Form 11-K / /Form 10-Q / /Form N-SAR

                 For Period Ended: December 31, 1999
                                  --------------------------------------------
                 /  / Transition Report on Form 10-K
                 /  / Transition Report on Form 20-F
                 /  / Transition Report on Form 11-K
                 /  / Transition Report on Form 10-Q
                 /  / Transition Report on Form N-SAR
                 For the Transition Period Ended:
                 ________________
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  READ INSTRUCTION (ON BACK PAGE) BEFORE PREPARING FORM. PLEASE PRINT OR TYPE.
    NOTHING IN THIS FORM SHALL BE CONSTRUED TO IMPLY THAT THE COMMISSION HAS
               VERIFIED ANY INFORMATION CONTAINED HEREIN.
- -------------------------------------------------------------------------------
If the notification relates to a portion of the filing checked above, identify
the Item(s) to which the notification relates:

PART I - REGISTRANT INFORMATION

NaPro BioTherapeutics, Inc.
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Full Name of Registrant

NA
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Former Name if Applicable

6304 Spine Road, Unit A
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Address of Principal Executive Office (Street and Number)

Boulder, Colorado 80301
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City, State and Zip Code

PART II - RULES 12b-25(b) AND (c)

If the subject report could not be filed without unreasonable effort or expense
and the registrant seeks relief pursuant to Rule 12b-25(b), the following should
be completed. (Check box if appropriate)


       (a)  The reasons described in reasonable detail in Part III of this
            form could not be eliminated without unreasonable effort or
            expense;
       (b)  The subject annual report, semi-annual report, transition report
            on Form 10-K, Form 20-F, 11-K or Form N-SAR, or portion thereof,
/X/         will be filed on or before the fifteenth calendar day following
            the prescribed due date; or the subject quarterly report of
            transition report on Form 10-Q, or portion thereof will be filed
            on or before the fifth calendar day following the prescribed due
            date; and
       (c)  The accountant's statement or other exhibit required by Rule
            12b-25(c) has been attached if applicable.

PART III - NARRATIVE

State below in reasonable detail the reasons why Forms 10-K, 20-F, 11-K, l0-Q,
N-SAR, or the transition report or portion thereof could not be filed within the
prescribed time period.


<PAGE>


The Registrant has historically been involved in a single line of business, the
development, manufacture and commercialization of paclitaxel. As previously
announced, the Registrant has been exploring the diversification of its business
into the acquisition and development of new compounds and products. The
Registrant is currently in advanced discussions for the licensing of technology,
the completion of which are imminent and would change the business direction of
the Registrant. The outcome of such negotiations will have an impact on the
Registrant's disclosures in the Form 10-K as they relate to a description of its
business and the analysis of its financial condition. Thus, the Registrant
requires additional time to complete and file its annual report on Form 10-K for
the fiscal year ended December 31, 1999. For the reasons set forth above, the
Registrant cannot timely file its Annual Report on Form 10-K without
unreasonable effort or expense. The Registrant will file its annual report on
Form 10-K no later than the fifteenth day after the due date of the report.

PART IV - OTHER INFORMATION

      (1)  Name and telephone number of person to contact in regard to this
           notification:

Gordon H. Link              303                   530-3891
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(Name)                  (Area Code)          (Telephone Number)

      (2)  Have all other periodic reports required under Section 13 or 15(d) of
           the Securities Exchange Act of 1934 or Section 30 of the Investment
           Company Act of 1940 during the preceding 12 months or for such
           shorter period that the registrant was required to file such
           report(s) been filed? If answer is no, identify report(s).

                                                             [X] Yes     No [  ]

      (3)  Is it anticipated that any significant change in results of
           operations from the corresponding period for the last fiscal year
           will be reflected by the earnings statements to be included in the
           subject report or portion thereof?

                                                             [  ] Yes     No [X]

           If so, attach an explanation of the anticipated change, both
           narratively and quantitatively, and, if appropriate, state the
           reasons why a reasonable estimate of the results cannot be made.

                           NaPro BioTherapeutics, Inc.
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                  (Name of Registrant as Specified in Charter)

has caused this notification to be signed on its behalf by the undersigned
hereunto duly authorized.

Dated:  March 30, 2000              By: /s/ Gordon H. Link
                                        Vice President, Chief Financial Officer

      INSTRUCTION: The form may be signed by an executive officer of the
      registrant or by any other duly authorized representative. The name and
      title of the person signing the form shall be typed or printed beneath the
      signature. If the statement is signed on behalf of the registrant by an
      authorized representative (other than an executive officer), evidence of
      the representative's authority to sign on behalf of the registrant shall
      be filed with the form.

               ____________________ ATTENTION ____________________

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Intentional misstatements or omissions of fact constitute Federal Criminal
Violations (See 18 U.S.C. 1001).
- --------------------------------------------------------------------------------

                              GENERAL INSTRUCTIONS

      1. This form is required by Rule 12b-25 (17 CFR 240.12b-25) of the General
         Rules and Regulations under the Securities Exchange Act of 1934.

      2. One signed original and four conformed copies of this form and
         amendments thereto must be completed and filed with the Securities and
         Exchange Commission, Washington, D.C. 20549, in accordance with Rule
         0-3 of the General Rules and Regulations under the Act. The information
         contained in or filed with the form will be made a matter of public
         record in the Commission files.

      3. A manually signed copy of the form and amendments thereto shall be
         filed with each national securities exchange on which any class of
         securities of the registrant is registered.

      4. Amendments to the notifications must also be filed on form 12b-25 but
         need not restate information that has been correctly furnished. The
         form shall be clearly identified as an amended notification.

      5. Electronic Filers. This form shall not be used by electronic filers
         unable to timely file a report solely due to electronic difficulties.
         Filers unable to submit a report within the time period prescribed due
         to difficulties in electronic filing should comply with either Rule 201
         or Rule 202 of Regulation S-T (ss.232.201 or ss.232.202 of this
         chapter) or apply for an adjustment in filing date pursuant to Rule
         13(b) of Regulation S-T (ss.232.13(b) of this chapter.


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