SHAMAN PHARMACEUTICALS INC
SC 13G/A, 1998-02-18
PHARMACEUTICAL PREPARATIONS
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                    SECURITIES AND EXCHANGE COMMISSION
                          WASHINGTON, D.C. 20549
                           -------------------

                               SCHEDULE 13G
                              (Rule 13d-102)

 (Date of Event Which Requires Filing of this Statement: December 31, 1997)

  Check the appropriate box to designate the rule pursuant to which this
                            Schedule is filed:

                            [X] Rule 13d-1(b)
                            [ ] Rule 13d-1(c)
                            [ ] Rule 13d-1(d)

              INFORMATION TO BE INCLUDED IN STATEMENTS FILED
               PURSUANT TO RULES 13d-1(b), (c) AND (d) AND
                AMENDMENTS THERETO FILED PURSUANT TO 13d-2

                            (Amendment No. 1)*

                       Shaman Pharmaceuticals, Inc.
                             (Name of Issuer)

                      Common Stock, $0.001 par value
                      (Title of Class of Securities)

                               819319 10 4
                              (Cusip Number)




- ---------------

*       The remainder of this cover page shall be filled out for a
        reporting person's initial filing on this form with respect to
        the subject class of securities, and for any subse quent
        amendment containing information which would alter the
        disclosures pro vided in a prior cover page.

        The information required in the remainder of this cover page
        shall not be deemed to be "filed" for the purpose of Section 18
        of the Securities Exchange Act of 1934 ("Act") or otherwise
        subject to the liabilities of that section of the Act but shall
        be subject to all other provisions of the Act (however, see the
        Notes).


CUSIP No. 819319 10 4                   13G    

- --------------------------------------------------------------------------
        (1)    NAME OF REPORTING  PERSONS
               I.R.S. IDENTIFICATION NO.
               OF ABOVE PERSONS (ENTITIES ONLY)
               Fletcher Asset Management, Inc.
- --------------------------------------------------------------------------
        (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP**
                                                                (a) [ ]
                                                                (b) [x]
- --------------------------------------------------------------------------
        (3)    SEC USE ONLY
- --------------------------------------------------------------------------
        (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
               Delaware

NUMBER OF             (5)    SOLE VOTING POWER
                             0
SHARES                ______________________________________________________

BENEFICIALLY          (6)    SHARED VOTING POWER
                               950,000
OWNED BY              ______________________________________________________

EACH                  (7)    SOLE DISPOSITIVE POWER
                             0
REPORTING             ______________________________________________________

PERSON WITH           (8)    SHARED DISPOSITIVE POWER
                             950,000
- --------------------------------------------------------------------------
        (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
               BY EACH REPORTING PERSON
                       950,000
- --------------------------------------------------------------------------
        (10)   CHECK BOX IF THE AGGREGATE AMOUNT
               IN ROW (9) EXCLUDES CERTAIN SHARES **              [ ]
- --------------------------------------------------------------------------
        (11)   PERCENT OF CLASS REPRESENTED
               BY AMOUNT IN ROW (9)
                      5.4%
- --------------------------------------------------------------------------
        (12)   TYPE OF REPORTING PERSON **
                      CO
- --------------------------------------------------------------------------
                 ** SEE INSTRUCTIONS BEFORE FILLING OUT!



CUSIP No. 819319 10 4                   13G   

- --------------------------------------------------------------------------
        (1)    NAME OF REPORTING  PERSONS
               I.R.S. IDENTIFICATION NO.
               OF ABOVE PERSONS (ENTITIES ONLY)
               Alphonse Fletcher, Jr.
- --------------------------------------------------------------------------
        (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP**
                                                                (a) [ ]
                                                                (b) [x]
- --------------------------------------------------------------------------
        (3)    SEC USE ONLY
- --------------------------------------------------------------------------
        (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
               United States

NUMBER OF             (5)    SOLE VOTING POWER
                             0
SHARES                ______________________________________________________

BENEFICIALLY          (6)    SHARED VOTING POWER
                             950,000
OWNED BY              ______________________________________________________

EACH                  (7)    SOLE DISPOSITIVE POWER
                             0
REPORTING             ______________________________________________________

PERSON WITH           (8)    SHARED DISPOSITIVE POWER
                             950,000
- --------------------------------------------------------------------------
        (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
               BY EACH REPORTING PERSON
                      950,000
- --------------------------------------------------------------------------
        (10)   CHECK BOX IF THE AGGREGATE AMOUNT
               IN ROW (9) EXCLUDES CERTAIN SHARES **          [ ]
- --------------------------------------------------------------------------
        (11)   PERCENT OF CLASS REPRESENTED
               BY AMOUNT IN ROW (9)
                      5.4%
- --------------------------------------------------------------------------
        (12)   TYPE OF REPORTING PERSON **
                      IN
- --------------------------------------------------------------------------
                 ** SEE INSTRUCTIONS BEFORE FILLING OUT!



ITEM 1(a).     NAME OF ISSUER:      Shaman Pharmaceuticals, Inc.

ITEM 1(b).     ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:
                 213 East Grand Avenue, South San Francisco, California  94080

ITEM 2(a).     NAME OF PERSON FILING:
                 Fletcher Asset Management, Inc. and Alphonse Fletcher, Jr.

ITEM 2(b).     ADDRESS OF PRINCIPAL OFFICE OR, IF NONE, RESIDENCE:
                 767 Fifth Avenue, 48th Floor, New York, New York 10153

ITEM 2(c).     CITIZENSHIP:
                 Fletcher Asset Management, Inc. is a corporation
                 organized under the laws of the State of Delaware.
                 Alphonse Fletcher, Jr. is a citizen of the United
                 States.

ITEM 2(d).     TITLE OF CLASS OF SECURITIES: Common Stock, $0.001 par value

ITEM 2(e).     CUSIP NUMBER: 819319 10 4

ITEM 3.        IF THIS STATEMENT IS FILED PURSUANT TO RULES  13d-1(b),
               OR 13d-2 (b), CHECK WHETHER THE PERSON FILING IS A:

               (a)[ ] Broker or dealer registered under Section 15 of the Act

               (b)[ ] Bank as defined in Section 3(a) (6) of the Act

               (c)[ ] Insurance Company as defined in Section 3(a) (19)
                      of the Act

               (d)[ ] Investment Company registered under Section 8 of
                      the Investment Company Act

               (e)[x] Investment Adviser registered under Section 203
                      of the Investment Advisers Act of 1940

               (f)[ ] Employee Benefit Plan or Endowment Fund; see
                      Rule 13d-1(b)(1)(ii)(F)

               (g)[ ] Parent Holding Company or control person, in
                      accordance with Rule 13d-1(b)(1)(ii)(G)

               (h)[ ] Savings Association as defined in Section 3(b)
                      of the Federal Deposit Insurance Act

               (i)[ ] Church Plan that is excluded from the definition
                      of an investment company under Section 3(c)(14) of
                      the Investment Company Act of 1940

               (j)[ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J)

               If this statement is filed pursuant to Rule 13d-1(c), check \
this box.  [  ]

ITEM 4.        OWNERSHIP.

               (a) Amount beneficially owned: 950,000

               (b) Percent of class:

               5.4% (based on 17,740,943 shares of Common Stock (the
"Common Stock") of Shaman Pharmaceuticals, Inc. (the "Company"),
including those reported to be outstanding as of October 31, 1997, as
reflected in the Company's quarterly report on Form 10-Q filed with the
Securities and Exchange Commission by the Company for the quarter ended
September 30, 1997 and the shares of Common Stock underlying convertible
securities held by the Discretionary Account (as defined below) that are
convertible within 60 days of December 31, 1997.)

               (c) Number of shares as to which such person has:

                   (i)      sole power to vote or to direct the vote
                            0
                   (ii)     shared power to vote or to direct the vote
                            950,000
                   (iii)    sole power to dispose or to direct the
                            disposition of 0
                   (iv)     shared power to dispose or to direct the
                             disposition of 950,000

               The amount of Common Stock reported to be beneficially
owned includes 400,000 shares of Common Stock issuable upon the
conversion of 400,000 shares of Series A Preferred Stock (the "Preferred
Stock") of the Company and 550,000 shares of Common Stock issuable upon
the exercise of a warrant issued by the Company. The Preferred Stock is
convertible and the warrant is exercisable within 60 days of December 31,
1997. The holdings reported reflect the amount of Common Stock that would
have been held had the Preferred Stock been converted and the warrant
been exercised on December 31, 1997.

               By virtue of Mr. Fletcher's position as President of
Fletcher Asset Management, Inc., a Delaware corporation ("FAM"), Mr.
Fletcher may be deemed to have the shared power to vote or direct the
vote of, and the shared power to dispose or direct the disposition of,
the 950,000 shares of Common Stock of the Company held by Fletcher
International, Ltd., a discretionary account managed by FAM (the
"Discretionary Account"), and, therefore, Mr. Fletcher may be deemed to
be the beneficial owner of such Common Stock.

ITEM 5.        OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.
               Not applicable.

ITEM 6.        OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF
               ANOTHER PERSON.

               This Schedule l3G is filed by FAM, which is an investment
adviser registered under Section 203 of the Investment Advisers Act of
1940, as amended, with respect to the 950,000 shares of Common Stock held
at December 31, 1997 by the Discretionary Account managed by FAM. By
reason of the provisions of Rule l3d-3 under the Act, FAM and Mr.
Fletcher may each be deemed to own beneficially the shares of Common
Stock owned by the Discretionary Account. The Discretionary Account has
the right to receive or the power to direct the receipt of dividends
from, or the proceeds from the sale of, such Common Stock purchased for
its account.

ITEM 7.        IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY
               WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE
               PARENT HOLDING COMPANY.
               Not applicable.

ITEM 8.        IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE
               GROUP.
               Not applicable.

ITEM 9.        NOTICE OF DISSOLUTION OF GROUP.
               Not applicable.

ITEM 10.       CERTIFICATION.  (if filing pursuant to Rule 13d-1(b))

               By signing below Fletcher Asset Management, Inc. and
Alphonse Fletcher, Jr. certify that, to the best of their knowledge and
belief, the securities referred to above were acquired and are held in
the ordinary course of business and were not acquired and are not held
for the purpose of or with the effect of changing or influencing the
control of the issuer of the securities and were not acquired and are not
held in connection with or as a participant in any transaction having
that purpose or effect.

                                SIGNATURE

               After reasonable inquiry and to the best of their
knowledge and belief, the undersigned certify that the information set
forth in this statement is true, complete and correct

                                    February 17, 1998


                                    /s/ ALPHONSE FLETCHER, JR.
                                    Alphonse Fletcher, Jr., as President of
                                    Fletcher
                                    Asset Management, Inc.


                                    /s/ ALPHONSE FLETCHER, JR.
                                    Alphonse Fletcher, Jr.





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