SHAMAN PHARMACEUTICALS INC
PRE 14A, 1999-04-20
PHARMACEUTICAL PREPARATIONS
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                                 SCHEDULE 14A
                                (Rule 14a-101)
                   INFORMATION REQUIRED IN PROXY STATEMENT
                           SCHEDULE 14A INFORMATION
         Proxy Statement Pursuant to Section 14(a) of the Securities
                             Exchange Act of 1934

             Filed by the registrant   [ X ]
             Filed by a party other than the registrant   [   ]
             
             Check the appropriate box:

      [ X ]  Preliminary Proxy Statement     
      [   ]  Confidential, for Use of the
             Commission Only(as permitted
             by Rule 14a-6(e)(2))
      [   ]  Definitive Proxy Statement
      [   ]  Definitive Additional Materials
      [   ]  Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

                         Shaman Pharmaceuticals, Inc.
- ------------------------------------------------------------------------------
               (Name of Registrant as Specified in Its Charter)

- ------------------------------------------------------------------------------
   (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

Payment of Filing Fee (Check the appropriate box):
      [ X ]  No fee required.
      [   ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 
             0-11.
      (1)    Title of each class of securities to which transaction applies:

- ------------------------------------------------------------------------------
      (2)    Aggregate number of securities to which transactions applies:

- ------------------------------------------------------------------------------
      (3) Per unit  price  or other  underlying  value of  transaction  computed
pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee
is calculated and state how it was determined):

- ------------------------------------------------------------------------------
      (4)    Proposed maximum aggregate value of transaction:

- ------------------------------------------------------------------------------
      (5)    Total fee paid:

- ------------------------------------------------------------------------------

      [   ]  Fee paid previously with preliminary materials:

- ------------------------------------------------------------------------------

      [   ]  Check box if any part of the fee is offset as provided by Exchange
Act Rule  0-11(a)(2)  and identify the filing for which the  offsetting  fee was
paid previously.  Identify the previous filing by registration statement number,
or the form or schedule and the date of its filing.

      (1)    Amount Previously Paid:

- ------------------------------------------------------------------------------
      (2)    Form, Schedule or Registration Statement No.:

- ------------------------------------------------------------------------------
      (3)    Filing Party:

- ------------------------------------------------------------------------------
      (4)    Date Filed:

- ------------------------------------------------------------------------------

<PAGE>

                          SHAMAN PHARMACEUTICALS, INC.
                              213 East Grand Avenue
                      South San Francisco, California 94080

Dear Stockholder:

      You are  cordially  invited to attend the Annual  Meeting of  Stockholders
("Annual Meeting") of Shaman Pharmaceuticals,  Inc. (the "Company"),  which will
be held at 9:00 A.M.Pacific Time on Friday, June 11, 1999 at The Embassy Suites,
250 Gateway Boulevard, South San Francisco, California 94080.

      At the Annual  Meeting,  you will be asked to  consider  and vote upon the
following proposals:

      (i)  To elect four Class II  directors  to serve on the Board of Directors
           for two  years  or  until  their  successors  are  duly  elected  and
           qualified;

      (ii) To  approve  an  amendment  to the  Company's  Amended  and  Restated
           Certificate of Incorporation (the "Restated Certificate") to effect a
           20-for-1  reverse  stock split of the  Company's  outstanding  Common
           Stock;

      (iii)To approve an amendment and  restatement to the Restated  Certificate
           to  increase  the  number  of  authorized  shares  of  the  Company's
           Preferred  Stock by  10,000,000  shares,  from  2,000,000  shares  to
           12,000,000 shares;

      (iv) To approve an amendment and  restatement to the Restated  Certificate
           to increase the number of authorized  shares of the Company's  Common
           Stock by 150,000,000  shares,  from 70,000,000  shares to 220,000,000
           shares;

      (v)  To approve an amendment and restatement of the Company's Restated 
           Certificate to (i)delete the provision stating that a transaction or
           series of transactions in which in excess of 50% of the Company's
           voting power is transferred will be treated as a liquidation, 
           dissolution or winding up of the Company, for purposes of causing a
           required liquidation preference distribution to the holders of the
           Company's Preferred Stock, and (ii)delete the reference to the Series
           D Preferred Stock from the section, to clarify that the section, as a
           result of the amendment in this proposal, no longer applies to the
           Series D Preferred Stock;

     (vi)  To approve amendments to the Company's 1992 Stock Option Plan (the
           "1992  Plan")  which will result in a series of periodic increases to
           the  number  of  shares  of  Common  Stock   available  for  issuance
           thereunder;  revise  the  automatic  option  grant  program for  non-
           employee Board members to provide each current and future non-
           employee Board  member with a one-time  stock option grant for shares
           of Common Stock equal to one-half of one percent (0.5%) of the number
           of voting shares of the Company's  capital stock  outstanding on the 
           grant date; extend the term of the 1992 Plan and increase the limit 
           on the maximum number of shares for which any one  participant may be
           granted  stock options per calendar year;

     (vii) To  ratify  the  appointment  of Ernst & Young  LLP as the  Company's
           independent auditors for the year ending December 31, 1999; and

    (viii) To  transact  such other  business  as may  properly  come before the
           Annual Meeting and any adjournment or postponement thereof.


<PAGE>

     Following  the  completion  of the June 11,  1999,  Annual  Meeting  of the
Company,  and pending approval of the necessary  proposals in this proxy, Shaman
expects  to  conduct  a Rights  Offering,  and  intends  to file a  registration
statement with the SEC covering the issuance of the Series R Preferred  Stock to
its  stockholders.  The Company plans to offer to stockholders on pro-rata basis
shares  having  an  aggregate  value  of  $10,000,000.  You  will  receive  more
information  on the Rights  Offering  following  the Annual  Meeting,  including
detailed Questions and Answers (Q&A).

     The  enclosed  Proxy  Statement  more fully  describes  the details of the
business  to be  conducted  at the  Annual  Meeting.  After  reading  the  Proxy
Statement,  please mark,  date,  sign and return the enclosed  proxy card in the
accompanying  reply  envelope  as soon as  possible.  If you  attend  the Annual
Meeting and vote by ballot,  your proxy will be  automatically  revoked and only
your vote at the Annual  Meeting  will be counted.  YOUR SHARES  CANNOT BE VOTED
UNLESS YOU MARK,  DATE,  SIGN AND RETURN THE ENCLOSED PROXY OR ATTEND THE ANNUAL
MEETING AND VOTE IN PERSON.

      After  careful  consideration,   the  Company's  Board  of  Directors  has
unanimously approved the proposals and recommends that you vote in favor of each
such proposal.

      We look forward to seeing you at the Annual Meeting.

- --------------------------------------------------------------------------------
      If you have any questions prior to the date of the Annual Meeting,  please
contact our investor hotline at (800) XXX-XXXX.
- --------------------------------------------------------------------------------

                                  Sincerely,

                                  Lisa A. Conte
                                  President, Chief Executive
                                  Officer, Chief Financial Officer
                                  and Director
May ____, 1999

================================================================================
                             IMPORTANT

      Please  mark,  date,  sign  and  return  the  enclosed  proxy promptly in 
the accompanying  postage-paid return envelope so that, if you are unable to 
attend the Annual Meeting,  your shares may be voted.
================================================================================




                                       2
<PAGE>



                          SHAMAN PHARMACEUTICALS, INC.

              -----------------------------------------------------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                             TO BE HELD JUNE 11, 1999
              -----------------------------------------------------

TO THE STOCKHOLDERS OF SHAMAN PHARMACEUTICALS, INC.:

      NOTICE  IS HEREBY  GIVEN  that the 1999  Annual  Meeting  of  Stockholders
("Annual Meeting") of Shaman Pharmaceuticals,  Inc., a Delaware corporation (the
"Company"),  will be held at 9:00 A.M. Pacific Time on Friday,  June 11, 1999 at
The Embassy  Suites,  250 Gateway  Boulevard,  South San  Francisco,  California
94080, for the following purposes:

      (1)  To  elect  four  Class  II  directors  to  serve  on the  Board of
           Directors for two years or until their successors are duly elected 
           and qualified. The nominees are G. Kirk Raab, Herbert H. McDade, Jr.,
           M. David Titus and Loren D. Israelsen;

      (2)  To approve an amendment to the Company's Amended and Restated
           Certificate of Incorporation (the "Restated Certificate") to effect a
           20-for-1  reverse  stock split of the  Company's  outstanding  Common
           Stock;

      (3)  To approve an amendment and  restatement to the Restated  Certificate
           to  increase  the  number  of  authorized  shares  of  the  Company's
           Preferred  Stock by  10,000,000  shares,  from  2,000,000  shares  to
           12,000,000 shares;

      (4)  To approve an amendment and  restatement to the Restated  Certificate
           to increase the number of authorized  shares of the Company's  Common
           Stock by 150,000,000  shares,  from 70,000,000  shares to 220,000,000
           shares;

      (5)  To approve an amendment and restatement of the Company's Restated 
           Certificate to (i)delete the provision stating that a transaction or
           series of transactions in which in excess of 50% of the Company's
           voting power is transferred will be treated as a liquidation, 
           dissolution or winding up of the Company, for purposes of causing a
           required liquidation preference distribution to the holders of the
           Company's Preferred Stock, and (ii)delete the reference to the Series
           D Preferred Stock from the section, to clarify that the section, as a
           result of the amendment in this proposal, no longer applies to the
           Series D Preferred Stock;

      (6)  To approve  amendments to the  Company's  1992 Stock Option Plan (the
           "1992 Plan")  which will result in a series of periodic  increases to
           the  number  of  shares  of  Common  Stock   available  for  issuance
           thereunder;   revise  the   automatic   option   grant   program  for
           non-employee  Board  members  to  provide  each  current  and  future
           non-employee  Board  member with a one-time  stock  option  grant for
           shares of Common Stock equal to one-half of one percent (0.5%) of the
           number of voting  shares of the Company's  capital stock  outstanding
           on the grant date; extend the term of the 1992 Plan and increase the 
           limit on the maximum  number of shares for which any one  participant
           may be granted stock options per calendar year;

      (7)  To  ratify  the  appointment  of Ernst & Young  LLP as the  Company's
           independent auditors for the year ending December 31, 1999; and

      (8)  To  transact  such other  business  as may  properly  come before the
           Annual Meeting and any adjournment or postponement thereof.

      The  foregoing  items of business  are more fully  described  in the Proxy
Statement accompanying this Notice.

      The record date for determining those stockholders  entitled to notice of,
and to vote at,  the Annual  Meeting  and any  adjournment  thereof is April 15,
1999.  The stock  transfer  books will not be closed between the record date and
the date of the Annual Meeting.  A list of the stockholders  entitled to vote at
the Annual  Meeting will be available for  inspection at the Company's  offices,
213 East Grand Avenue, South San Francisco, California 94080, for a period of 10
days prior to the Annual Meeting.



                                      
<PAGE>

      All  stockholders  are cordially  invited to attend the Annual  Meeting in
person.   Whether  or  not  you  plan  to  attend,  please  carefully  read  the
accompanying  Proxy  Statement,  which describes the matters to be voted upon at
the Annual Meeting,  and mark,  date, sign and return the enclosed proxy card in
the reply envelope provided. Should you receive more than one proxy because your
shares are  registered in different  names and  addresses,  each proxy should be
returned to ensure that all your shares will be voted. You may revoke your proxy
at any time prior to the Annual  Meeting.  If you attend the Annual  Meeting and
vote by ballot, your proxy vote will be revoked automatically and only your vote
at the Annual Meeting will be counted. The prompt return of your proxy card will
assist us in preparing for the Annual Meeting.

                                    Sincerely,

                                    Lisa A. Conte
                                    President, Chief Executive
                                    Officer, Chief Financial Officer
                                    and Director
South San Francisco, California
May ____, 1999

YOUR VOTE IS VERY IMPORTANT,  REGARDLESS OF THE NUMBER OF SHARES YOU OWN. PLEASE
READ THE ATTACHED PROXY STATEMENT  CAREFULLY.  IF YOU DO NOT EXPECT TO ATTEND IN
PERSON,  PLEASE  COMPLETE,  SIGN, DATE AND RETURN THE ENCLOSED PROXY CARD IN THE
ACCOMPANYING ENVELOPE AS PROMPTLY AS POSSIBLE.




                                       2
<PAGE>



                          SHAMAN PHARMACEUTICALS, INC.
                              213 East Grand Avenue
                      South San Francisco, California 94080
                  --------------------------------------------

                                 PROXY STATEMENT
                  --------------------------------------------

                     For the Annual Meeting of Stockholders
                           To Be Held on June 11, 1999


                      GENERAL INFORMATION FOR STOCKHOLDERS


      The  enclosed  proxy  ("Proxy")  is  solicited  on  behalf of the Board of
Directors (the "Board") of Shaman Pharmaceuticals,  Inc., a Delaware corporation
(the "Company"), for use at the 1999 Annual Meeting of Stockholders (the "Annual
Meeting") to be held at 9:00 A.M.  Pacific Time on Friday, June 11, 1999, at the
Embassy Suites,  250 Gateway Boulevard,  South San Francisco,  California 94080,
and at any adjournment thereof.

      This Proxy  Statement and the  accompanying  form of Proxy are to be first
mailed to the  stockholders  entitled to vote at the Annual  Meeting on or about
May 4, 1999.

Record Date and Voting

     The  specific  proposals  to be  considered  and acted  upon at the  Annual
Meeting are  summarized  in the  accompanying  Notice and are  described in more
detail  in this  Proxy  Statement.  All  stockholders  of record at the close of
business on April 15, 1999 are entitled to notice of, and to vote at, the Annual
Meeting.  However,  the holders of Series D Preferred Stock are entitled to vote
only on Proposal  Three.  As of the close of  business on such date,  there were
40,745,876 shares of the Company's Common Stock, par value $0.001 per share (the
"Common  Stock"),  outstanding and entitled to vote, held by  approximately  952
stockholders of record.  In addition,  400,000 shares of the Company's  Series A
Preferred  Stock  were  outstanding  and  entitled  to  vote  and  held  by  one
stockholder  of  record,  115,958  shares  of  Series  C  Preferred  Stock  were
outstanding and entitled to vote and held by 21  stockholders,  and 2,016 shares
of Series D Preferred Stock were  outstanding  and held by 6 stockholders.  Each
holder of Common  Stock as of the record  date is  entitled to one vote for each
share of Common  Stock  held by such  stockholder  as of the record  date.  Each
holder of Series C  Preferred  Stock as of the record  date is  entitled  to six
votes for each share of Series C Preferred Stock held by such  stockholder as of
the record date.  Each holder of Series D Preferred  Stock as of the record date
is entitled to one vote for each share of Series D Preferred  Stock held by such
stockholder as of the record date.  Each share of Series A Preferred Stock as of
the record  date is  entitled  to one vote for each share of Series A  Preferred
Stock.

     Directors are determined by a plurality  vote.  Proposals Two and Four will
be  decided  by  the  affirmative  vote  of a  majority  of  the  voting  shares
outstanding  on  the  record  date.  Proposal  Three  will  be  decided  by  the
affirmative  vote of (a) a majority of all shares of the Company's Common Stock,
including all shares of Series A Preferred  Stock,  Series C Preferred Stock and
Series D Preferred  Stock and (b) a majority of shares of the Series A Preferred
Stock,  Series C Preferred Stock and Series D Preferred Stock, voting separately
as a class.  Proposal  Five will be  decided  by the  affirmative  vote of (a) a
majority of all of the Company's outstanding voting shares, including all shares
of Common Stock, Series A Preferred Stock, Series C Preferred Stock and Series D
Preferred  Stock,  voting together as a single class,  and (b) a majority of the
shares of the Series A Preferred  Stock,  Series C Preferred  Stock and Series D
Preferred Stock,  each voting as a separate series.  All other matters submitted
for  stockholder  approval  at  this  Annual  Meeting  will  be  decided  by the
affirmative  vote of a majority of shares  present in person or  represented  by
proxy and entitled to vote on such matters. If a choice as to the matters coming
before the Annual Meeting has been specified by a stockholder on the Proxy,  the
shares will be voted  accordingly.  If no contrary  instructions  are given, the
shares  will be  voted  for the  election  of all  four  directors  (unless  the
authority to vote on the election of any such director is withheld) and in favor
of the approval of all proposals  described in the accompanying Notice of Annual
Meeting  and in  this  Proxy  Statement.  All  votes  will be  tabulated  by the
inspector of election  appointed for the meeting,  who will separately  tabulate
affirmative and negative  votes,  abstentions and broker  non-votes  (i.e.,  the
submission  of a Proxy  by a broker  or  indicating  the  lack of  discretionary
authority to vote on the matter). Abstentions and broker non-votes



                                       


                                       1
<PAGE>



are counted as present for purposes of  determining  the presence  or absence
of a quorum for the transaction of business. Abstentions will be counted towards
the tabulation of votes cast on proposals presented to the stockholders and will
have the same effect as negative  votes,  whereas  broker  non-votes will not be
counted  for  purposes  of  determining  whether a proposal  has been  approved.
However,  because  Proposals Two,  Three,  Four and Five require the affirmative
vote of a majority  of the  Company's  outstanding  voting  shares on the Record
Date,  both  abstentions  and  broker  non-votes  with  respect  to any of those
particular  proposals will have the same effect as votes against the approval of
that proposal.

      Any  stockholder  or  stockholder's   representative  who,  because  of  a
disability,  may need special assistance or accommodation to allow him or her to
participate  at  the  Annual  Meeting  may  request  reasonable   assistance  or
accommodation  from the Company by contacting  Investor  Relations in writing at
213 East Grand Avenue, South San Francisco,  California 94080 or by telephone at
(650) 952-7070. To provide the Company sufficient time to arrange for reasonable
assistance, please submit such requests by May 28, 1999.

Revocability of Proxies

      Any stockholder giving a Proxy pursuant to this solicitation may revoke it
at any time prior to its exercise by filing with the Secretary of the Company at
its principal  executive offices at 213 East Grand Avenue,  South San Francisco,
California  94080, a written notice of such  revocation or a duly executed Proxy
bearing a later date, or by attending the Annual Meeting and voting in person.

Solicitation

      The  Company  will bear the entire  cost of  solicitation,  including  the
preparation,  assembly,  printing  and mailing of the Notice of Annual  Meeting,
this  Proxy  Statement,  the Proxy  and any  additional  solicitation  materials
furnished to stockholders. Copies of solicitation materials will be furnished to
brokerage houses,  fiduciaries and custodians holding shares in their names that
are  beneficially  owned by others so that they may  forward  this  solicitation
material to such  beneficial  owners.  The Company has engaged  ____________  to
provide  routine  advice and  services  for Proxy  solicitation.  ________  will
receive approximately $_____ from the Company for such advice and services, plus
reimbursement of costs incurred in forwarding the solicitation  materials to the
beneficial owners of Common Stock and Series C Preferred Stock. To assure that a
quorum  will be present in person or by proxy at the Annual  Meeting,  it may be
necessary for _______, certain officers, directors, employees or other agents of
the  Company to solicit  proxies by  telephone,  facsimile  or other means or in
person.  Except with respect to ________,  the Company will not compensate  such
individuals for any such services.  Except as described  above, the Company does
not presently intend to solicit proxies other than by mail.

                                    IMPORTANT

      Please mark,  date, sign and return the enclosed Proxy in the accompanying
postage-prepaid,  return envelope as soon as possible so that, if you are unable
to attend the Annual Meeting, your shares may be voted.





                                       2
<PAGE>




                 MATTERS TO BE CONSIDERED AT THE ANNUAL MEETING

                                  PROPOSAL ONE

                              ELECTION OF DIRECTORS



      The Company's Amended and Restated  Certificate of Incorporation  provides
for a classified Board consisting of two classes of directors,  designated Class
I and Class II, each serving a term of two years,  with such terms  staggered so
that  only  one  class  of  directors  is  elected  at each  annual  meeting  of
stockholders.  At the Annual Meeting, four Class II directors will be elected to
serve for two years or until their  successors  shall have been duly elected and
qualified or until their death,  resignation or removal.  The Board has selected
four nominees,  four of whom are current  directors of the Company.  Each person
nominated  for election has agreed to serve if elected,  and  management  has no
reason to  believe  that any  nominee  will be  unavailable  to serve.  The four
candidates  receiving  the  highest  number of  affirmative  votes of the shares
entitled to vote at the Annual Meeting will be elected. If any nominee is unable
to or declines to serve as a director, the proxies may be voted for a substitute
nominee designated by the current Board. As of the date of this Proxy Statement,
the Board is not aware of any nominee who is unable or will  decline to serve as
a director.

Information with Respect to Directors

     Set forth below is information regarding the nominees, as of April 15,1999:

<TABLE>
<CAPTION>


 Name of Nominees        Position(s) with the Company     Age     Director Since
 ----------------        ----------------------------     ---     --------------                           
<S>                      <C>                             <C>     <C>      
 G. Kirk Raab              Chairman of the Board          63          1992     
 Herbert H. McDade, Jr.    Director                       72          1991
 M. David Titus            Director                       41          1990
 Loren D. Israelsen        Director                       43          1999
      
</TABLE>


     Set forth below is information  regarding the continuing  directors,  as of
April 15, 1999:

<TABLE>
<CAPTION>

 Name of Nominees        Position(s) with the Company     Age     Director Since
 ----------------        ----------------------------     ---     --------------                           
<S>                      <C>                             <C>      <C> 
 Lisa A. Conte           Director, President, Chief       40          1989
                          Executive Officer and Chief                                
                          Financial Officer     
 Adrian D.P. Bellamy     Director                         57          1997            
 Jeffrey Berg            Director                         51          1998

</TABLE>

Business   Experience  of  Director  Nominees  for  Term  Ending  Upon  the 2001
Annual Meeting of Stockholders

     G. Kirk Raab became a director of the Company in January  1992 and Chairman
of the Board in September 1995. Mr. Raab was President,  Chief Executive Officer
and director of Genentech,  Inc.  ("Genentech")  from February 1990 to July 1995
and  President,  Chief  Operating  Officer and director  from  February  1985 to
January 1990.  Before joining  Genentech,  Mr. Raab was  associated  with Abbott
Laboratories,  serving as President,  Chief Operating Officer and director.  Mr.
Raab  holds a B.A.  in  Political  Science  from  Colgate  University,  where he
currently  serves  as a  trustee.  Mr.  Raab is also  Chairman  of the  Board of
Connectics,   Inc.  and  Oxford  GlycoSciences  (UK)  Ltd.  and  a  director  of
Accumetrics,   Inc,  Applied  Imaging  Corp.,  Bridge  Medical,   Inc.  and  LXR
Biotechnology, Inc.

     Herbert H. McDade, Jr. became a director of the Company in October 1991. He
has  served as  Chairman  of the Board and  Chief  Executive  Officer  of Chemex
Pharmaceuticals,  Inc.  ("Chemex")  since  February 1989 and as Chief  Executive


                                       3
<PAGE>

Officer from February 1989 through  January 1996, when Chemex merged with Access
Pharmaceutical  Corporation  ("Access") and the combined entity changed its name
to Access. From October 1986 to January 1988, Mr. McDade was Chairman, President
and Chief Executive  Officer of Armour  Pharmaceuticals,  Inc., after previously
serving as  President,  International  Health Care Division of the Revlon Health
Care Group. Mr. McDade holds a B.S. in Biology from the University of Notre Dame
and a B.P.H. in Theology and Philosophy from Laval University. He is Chairman of
the Board of Access and a director of Cytrx,  Inc.,  Discovery  Ltd. and several
privately held companies.

     M. David Titus became a director of the Company in April 1990. Mr. Titus is
currently a General Partner of Windward Ventures Management,  L.P. ("Windward"),
a venture  capital firm,  which he founded in November  1997.  Prior to founding
Windward,  Mr.  Titus was  Managing  Director  of Windward  Ventures,  a venture
capital  consulting and investment firm, which he founded in 1993. From May 1986
to December 1992, he served in various capacities at Technology Funding, Inc., a
venture capital firm, including Group Vice President,  Technology Funding, Inc.,
and General Partner of Technology  Funding Limited.  Prior to joining Technology
Funding,  Inc. in May 1986, Mr. Titus was a founder and Senior Vice President of
the  Technology  Division of Silicon  Valley  Bank.  Mr.  Titus earned a B.A. in
Economics from the University of California,  Santa Barbara. He is a director of
several privately held companies.

      Loren D.  Israelsen  became a director of the  Company in April 1999.  Mr.
Israelsen has been President of LDI Group,  a consulting  firm  specializing  in
dietary supplement and phytomedicine  issues, since 1997. From 1990 to 1997, Mr.
Israelsen  practiced law at a private  firm.  From 1981 to 1990,  Mr.  Israelsen
served in various positions at Murdock International Corp.,  including President
from 1989 to 1990, Vice President of Strategic Development from 1986 to 1989 and
General  Counsel from 1981 to 1986.  While acting as Vice President of Strategic
Development,  he identified and negotiated  several license  agreements to bring
the world's  leading  phytomedicines,  including  Ginkgo  biloba  extract,  milk
thistle extract,  echinacea,  evening primrose oil, and saw palmetto extract, to
the United States. Mr. Israelsen has served as General Counsel/Vice President to
the American Herbal Products  Association,  Co-counsel to the European  American
Phytomedicine Coalition,  industry liaison to FDA's expert advisory committee on
Ephedra and advisor to the Natural  Products  Quality  Assurance  Alliance,  the
Office of Technology  Assessment  and the Office of Dietary  Supplements.  Since
1992, he has served as Executive Director of the Utah Natural Products Alliance,
which was instrumental in developing and passing the Dietary  Supplement  Health
and Education Act of 1994.

Business  Experience of Continuing  Directors for Term Ending Upon the 2000
Annual Meeting of Stockholders

      Lisa A. Conte founded the Company in May 1989 and currently  serves as the
Company's  President,  Chief Executive Officer and Chief Financial Officer and a
director. From 1987 to 1989, Ms. Conte was Vice President at Technology Funding,
Inc., a venture  capital firm,  where she was  responsible  for the analysis and
management of healthcare industry investments.  From 1985 to 1987, she conducted
risk and strategy  audits for venture capital  portfolio  companies at Strategic
Decisions  Group,  a management  consulting  firm. Ms. Conte received an A.B. in
Biochemistry from Dartmouth College, an M.S. in Physiology/Pharmacology from the
University  of  California,  San Diego and an M.B.A.  from The Amos Tuck School,
Dartmouth College.

     Adrian D.P. Bellamy became a director of the Company in October 1997. Since
April 1995, Mr. Bellamy has served as Chairman and a director of each of Airport
Group  International  Holdings LLC and Gucci Group N.V. From  September  1983 to
April 1995,  Mr.  Bellamy served as Chairman of the Board of Directors and Chief
Executive Officer of DFS Group Limited, a specialty retailer. He received a B.A.
in Communications and an M.B.A. from the University of South Africa. Mr. Bellamy
is a director of The Body Shop, Inc., The Body Shop  International PLC, The Gap,
Inc., Paragon Trade Brands, Inc. and Williams-Sonoma, Inc.

     Jeffrey  Berg became a director  of the Company in June 1998.  Mr. Berg has
been  the  Chairman  and  Chief  Executive  Officer  of  International  Creative
Management,  Inc.  since  1985.  Mr.  Berg,  one of the  leading  agents  in the
entertainment  industry,  has  been in the  entertainment  industry  for over 25
years.  Mr. Berg received a B.A.  from the  University of California at Berkeley
and a Master of Liberal  Arts from the  University  of Southern  California.  He
served as Co-Chair of the  California  Information  Technology  Council and is a
director of Oracle Corporation and Excite, Inc.

                                       4
<PAGE>

Number of Directors; Relationships

      The  Company's  Bylaws  authorize the Board to fix the number of directors
serving on the Board,  provided that such number shall not be less than five nor
more than  nine.  The  number of  directors  is  currently  fixed at seven.  All
directors hold office until the second annual meeting of stockholders  following
the annual meeting of stockholders at which such director was elected,  or until
their successors have been duly elected and qualified.

      There are no family relationships among executive officers or directors of
the Company.

Board Meetings and Committees

      The Board  held ten  meetings  during  the 1998  fiscal  year and acted by
written  consent  on two  occasions.  The  Board  has an Audit  Committee  and a
Compensation  Committee.  All  directors  who  served on the Board of  Directors
throughout the 1998 fiscal year  participated in or attended at least 75% of the
aggregate  of (i) the total  number of meetings of the Board of  Directors  held
during  the period in which they  served and (ii) the total  number of  meetings
held by all  committees  of the Board on which he or she served  during the past
fiscal year.

      The Audit  Committee is primarily  responsible  for annually  recommending
independent  auditors for  appointment by the Board,  for reviewing the services
performed by the Company's  independent auditors and reviewing reports submitted
by the independent auditors. The Audit Committee includes two directors, Messrs.
Titus and Raab.  The Audit  Committee  held no  meetings  during the 1998 fiscal
year.

      The  Compensation  Committee,  which is  comprised  of Messrs.  McDade and
Bellamy,  reviews and approves the Company's general  compensation  policies and
practices,  sets compensation  levels for the Company's  executive  officers and
administers  the  Company's  1992 Stock  Option Plan (the "1992 Plan") and other
employee  benefits  programs.  During the 1998  fiscal  year,  the  Compensation
Committee held eight meetings.

Director Compensation

     Each non-employee  Board member receives an annual retainer fee of $10,000,
provided  the  non-employee  Board  member  attends  at least  75% of the  Board
meetings. In addition,  non-employee Board members are reimbursed for reasonable
expenses incurred in connection with their attendance at such meetings.

      While the information given below is for historical purpose,  effective as
of April  _____,  1999,  each member of the Board of Directors  has  surrendered
their outstanding options to purchase shares of the Company's Common Stock.

      Under the Automatic Option Grant Program in effect under the 1992 Plan for
the 1998 fiscal year,  each  individual  who first became a  non-employee  Board
member,  whether  through  appointment  by the  Board  or upon  election  by the
stockholders, was automatically granted, at the time of such initial appointment
or election,  an option to purchase 20,000 shares of Common Stock, provided such
individual had not previously been in the Company's employ. In addition,  on the
date of the 1998 Annual Meeting of  Stockholders,  each individual who continued
to serve as a non-employee Board member received an automatic stock option grant
under the program,  provided he or she has served as a Board member for at least
six months. The option grant allowed the continuing non-employee Board member to
purchase that number of shares of Common Stock determined by dividing $50,000 by
the average  closing  selling price per share of Common Stock for the 30 trading
days  immediately  preceding the date of the Annual Meeting on which such option
was granted,  but in no event would such grant be for more than 7,500 shares nor
fewer than 5,000 shares per non-employee  Board member.  Each granted option had
an exercise  price per share equal to the fair market  value per share of Common
Stock on the grant date and had a maximum  term of 10 years  measured  from such
grant date.  The option  would  become  exercisable  for the option  shares in a
series  of  24  successive  equal  monthly   installments  upon  the  optionee's
completion of each month of Board service over the 24-month period measured from
the grant date. The option would,  however,  become immediately  exercisable for
all the option  shares  upon  certain  changes in  control or  ownership  of the
Company.

                                       5
<PAGE>

      Pursuant  to the  foregoing  provisions  of  the  Automatic  Option  Grant
Program,  Mr. Berg received an option grant for 20,000 shares of Common Stock on
June 30, 1998 in  connection  with his  initial  appointment  to the Board.  The
option has an  exercise  price of $3.375 per share,  the fair  market  value per
share of the Common Stock on the grant date.

      Messrs. McDade, Raab, Titus and Bellamy each received, on the May 15, 1998
date of the 1998 Annual  Stockholders  Meeting, an option grant for 7,500 shares
of Common Stock under the Automatic  Option Grant Program with an exercise price
per share of $4.9375,  the fair market  value per share of Common  Stock on that
date.

      On October 20,  1998,  the  Compensation  Committee in its capacity as the
Plan  Administrator  implemented  an  option  cancellation/regrant  program  for
certain key  consultants  and the  non-employee  Board  members  (other than the
members of the  Compensation  Committee)  holding  options  under the 1992 Plan.
Pursuant to that program,  each eligible non-employee Board member was given the
opportunity  to  surrender  his  outstanding  options  under  the 1992 Plan with
exercise  prices in excess of $1.4375 per share in return for a new option grant
for the same number of shares but with an  exercise  price of $1.4375 per share,
the closing  selling  price per share of Common  Stock as reported on the Nasdaq
National  Market on the October  20,  1998 grant date of the new option.  To the
extent the  higher-priced  option was  exercisable  for any option shares on the
October 20, 1998  cancellation  date,  the new option  granted in replacement of
that  option  would  become  exercisable  for  those  shares  in a series  of 12
successive  equal monthly  installments  upon the optionee's  completion of each
month of service over the  one-year  period  measured  from the October 20, 1998
grant date. The option would become  exercisable for the remaining option shares
in one or more  installments  over the optionee's  period of continued  service,
with each such  installment  to vest on the same vesting date in effect for that
installment under the cancelled higher-priced option. The following non-employee
Board members participated in the October 20, 1998 cancellation/regrant  program
with respect to the indicated number of option shares:  Mr. Raab, 344,282 shares
with a weighted average  exercise price of $5.528 per share;  Mr. Titus,  58,282
shares with a weighted  average  exercise price of $6.4242 per share;  Mr. Berg,
20,000 shares with a weighted average exercise price of $3.3750 per share.  Each
of the foregoing directors subsequently surrendered such options.

     If Proposal Six is approved by the stockholders at the 1999 Annual Meeting,
substantial revisions will be made to the Automatic Option Grant Program for the
non-employee  Board members.  For further  information  concerning the Automatic
Option Grant  Program,  please see Proposal Six below for a discussion  of those
revisions.

     On May 1, 1997,  the Company  approved a  consulting  arrangement  with Mr.
Titus, one of the non-employee Board members,  pursuant to which he was to serve
as a consultant to the Company on financing  matters and  financial  operations.
Under this  arrangement,  Mr.  Titus was paid  consulting  fees in the amount of
$36,000 for the 1998 fiscal year.  This agreement  expired in June 1998. As part
of the initial consulting agreement, Mr. Titus was granted an option to purchase
up to 14,000 shares of Common Stock under the Discretionary Option Grant Program
in effect under the Plan. Such option has an exercise price of $5.375 per share,
the fair market  value of the  Company's  Common Stock on the May 22, 1997 grant
date of that  option  and was  exercisable  in full at any time prior to May 22,
2007.  This  option  was  surrendered  on  October  20,  1998  under the  option
cancellation/regrant  program,  in return  for a new  option  grant for the same
number of shares but with an  exercise  price of $1.4375  per share.  The option
would  have  become  exercisable  in a series  of 12  successive  equal  monthly
installments  over the one-year  period measured from the October 20, 1998 grant
date; however, the option has been surrendered and is no longer outstanding.

     In August 1995,  the Company  entered into a  consulting  arrangement  (the
"Consulting  Arrangement")  with Mr. G. Kirk Raab,  Chairman  of the  Board.  As
consideration for the special  consulting  services Mr. Raab performed under the
Consulting Arrangement,  Mr. Raab was paid an annual consulting fee of $100,000.
In  addition,  he was  granted an option for 200,000  shares of Common  Stock on
August 21, 1995 with an exercise price per share of $5.50, the fair market value
per share of  Common  Stock on that  date.  The  option  was  granted  under the
Discretionary  Option  Grant  Program in effect  under the Plan,  and the option
would  have  become  exercisable  in a series  of 48  successive  equal  monthly
installments  over the four-year  period measured from the August 21, 1995 grant
date,  provided Mr. Raab continued to render services to the Company pursuant to
his  Consulting  Arrangement.  This option was  surrendered  on October 20, 1998
under the option cancellation/regrant  program, in return for a new option grant
for the same number of shares but with an  exercise  price of $1.4375 per share.
To the extent,  this option was exercisable for any option shares on the October
20, 1998 cancellation date, the new option granted in replacement of that option
would have  become  exercisable  for those  shares in a series of 12  successive


                                       6
<PAGE>

equal  monthly  installments  over  the  one-year  period   measured  from   the
October 20, 1998 grant date.  The option would have become  exercisable  for the
remaining option shares in one or more  installments  upon the optionee's period
of continued  service,  with each such  installment  to vest on the same vesting
date in effect for that installment  under the cancelled  higher-priced  option.
The option  would have,  however,  become  immediately  exercisable  for all the
option  shares upon  certain  changes in control or  ownership  of the  Company.
However,  this  option has been  surrendered  and is no longer  outstanding  In
addition,  in connection  with his services as a director and as Chairman of the
Board,  Mr. Raab received an annual retainer fee of $60,000,  payable after each
Annual Meeting of  Stockholders so long as Mr. Raab continued to render services
to the Company as Chairman of the Board.  The Company paid a total of $66,667 of
the  consulting  fees in cash and on November 7, 1998,  issued 135,652 shares of
Common Stock in payment of his consulting services for the 1998 fiscal year. The
Company and Mr. Raab have agreed to terminate the compensation component of this
agreement, and no further payments are to be due under this agreement.  Mr. Raab
still serves as Chairman of the Board.

      In January 1999, the Company entered into a consulting  agreement with Mr.
Loren D. Israelsen, a director of the Company,  pursuant to which he is to serve
as an interim Chief Executive  Officer of Shaman's  Botanicals  division.  Under
this  agreement,  Mr.  Israelsen  was paid a total of $30,000 for his service in
January and February 1999. In addition, upon further funding of the Company, Mr.
Israelsen  is to be paid $10,000 in deferred  consulting  expenses and a project
retainer to help close a corporate deal for Shaman's Botanicals  division.  Such
retainer will be paid in three  installments.  Mr. Israelsen will also receive a
success  payment for each corporate  partnership as a percentage of the up front
fee  received  from such  partner,  which fee varies from three to five  percent
depending upon the timing of closing such partnership.

      No other  compensation  was paid or accrued for  directors  of the Company
with  respect to their 1998  services  as  directors  of or  consultants  to the
Company.

Recommendation of the Board of Directors

      The Board recommends that the  stockholders  vote IN FAVOR OF the election
of each of the above  nominees to serve as  directors  of the Company  until the
2001 annual meeting of  stockholders  or until their  successors  have been duly
elected and qualified or until their death, resignation or removal.





                                       7
<PAGE>




                                  PROPOSAL TWO

                               REVERSE STOCK SPLIT

General

     The Board of  Directors of the Company has approved a proposal to amend the
Company's  Amended and Restated  Certificate  of  Incorporation  (the  "Restated
Certificate")  to  effect  a  20-for-1  reverse  stock  split  of the  Company's
outstanding Common Stock, subject to the approval of the Company's stockholders.
This proposal provides for the combination and reclassification of the presently
issued and outstanding  shares of Common Stock,  into a smaller number of shares
of identical Common Stock, on the basis of one share of Common Stock for each 20
shares of Common Stock  previously  issued and  outstanding  (the "Reverse Stock
Split").  Except  as may  result  from the  rounding  of  fractional  shares  as
described below,  each stockholder will hold the same percentage of Common Stock
outstanding  immediately  following the Reverse Stock Split as each  stockholder
did  immediately  prior to the Reverse Stock Split. If approved by the Company's
stockholders as provided herein,  the Reverse Stock Split will be effected by an
amendment and restatement of the Company's Restated Certificate in substantially
the form  attached to this Proxy  Statement  as Appendix A (the  "Reverse  Stock
Split  Amendment"),  and will  become  effective  upon the filing of the Reverse
Stock Split  Amendment  with the Secretary of State of Delaware (the  "Effective
Time"). The Amended and Restated Certificate of Incorporation attached hereto as
Appendix  A  includes  the  amendment  set  forth in this  Proposal  Two and the
amendments set forth in Proposals 3, 4 and 5 of this Proxy  Statement.  Only the
amendments  approved by the  stockholders  will  be  included  in the  Restated
Certificate of  Incorporation  as filed with the Secretary of State of Delaware.
The  following  discussion  is qualified in its entirety by the full text of the
Reverse Stock Split Amendment, which is incorporated by reference herein.

      At the Effective  Time,  each share of Common Stock issued and outstanding
will  automatically  be  reclassified  and  converted  into 1/20th of a share of
Common Stock.  Fractional  shares of Common Stock will not be issued as a result
of the Reverse Stock Split.  Stockholders entitled to receive a fractional share
of Common  Stock as a  consequence  of the Reverse  Stock  Split will,  instead,
receive one share of Common Stock.

      The  Company  expects  that,  if  this  Proposal  Two is  approved  by the
stockholders  at the Annual  Meeting,  the Reverse Stock Split Amendment will be
filed promptly.  However,  notwithstanding  approval of this Proposal Two by the
stockholders of the Company, the Board of Directors of the Company may elect not
to file,  or to delay the filing of, the Reverse Stock Split  Amendment,  if the
Board  determines  that filing the Reverse Stock Split Amendment would not be in
the best interest of the Company's stockholders at such time. Factors leading to
such a determination could include,  without limitation,  any possible effect on
future securities offerings (see "Reasons for the Reverse Stock Split" below).

     Following  the  completion  of the June 11,  1999,  Annual  Meeting  of the
Company,  and pending approval of the necessary  proposals in this proxy, Shaman
expects  to  conduct  a Rights  Offering,  and  intends  to file a  registration
statement with the SEC covering the issuance of the Series R Preferred  Stock to
its  stockholders.  The Company plans to offer to stockholders on pro-rata basis
shares  having  an  aggregate  value  of  $10,000,000.  You  will  receive  more
information  on the Rights  Offering  following  the Annual  Meeting,  including
detailed Questions and Answers (Q&A).

Reasons for the Reverse Stock Split

      The  primary  purpose  of  the  Reverse  Stock  Split  is to  combine  the
outstanding  shares  of the  Company's  Common  Stock  so that the  Company  has
adequate  authorized but unissued  shares of Common Stock available for issuance
upon conversion of the Company's  Series C Preferred  Stock,  Series D Preferred
Stock and proposed Series R Preferred  Stock.  The Company may not have adequate
shares of Common Stock available for issuance upon such  conversions.  If shares
are not available to accommodate  conversion of the Series C Preferred Stock and
Series D Preferred  Stock when  requested,  the Company will be in breach of its
obligations and therefore will face  significant  penalties under the agreements
relating to the issuance of such  securities  and may entitle the holders of the
Series C and/or Series D Preferred Stock to have their shares redeemed for cash.
The  Company  does not have the  financial  resources  to  redeem  such  shares.
Additionally, the Company expects to issue shares of Series R Preferred Stock in
connection  with its  proposed  Rights  Offering,  and the  Company  must have a
significant  number of  shares  of Common  Stock  available  for  issuance  upon
conversion of such shares of Series R Preferred Stock.

                                       8
<PAGE>

      Another  effect  of the  Reverse  Stock  Split  is that by  combining  the
outstanding  shares of Common Stock, the Common Stock  outstanding  after giving
effect to the Reverse  Stock Split  trades at a  significantly  higher price per
share than the Common  Stock  outstanding  before  giving  effect to the Reverse
Stock Split.  The Company  anticipates  that,  following the consummation of the
Reverse  Stock  Split,  the Common Stock will trade at a price per share that is
significantly higher than the current market price of the Common Stock. However,
there can be no assurance that,  following the Reverse Stock Split,  such higher
price will be maintained.

      For the above reasons,  the Company  believes that the Reverse Stock Split
is in the best interests of the Company and its stockholders. However, there can
be  no   assurances   that  the  Reverse  Stock  Split  will  have  the  desired
consequences.

Effect of the Reverse Stock Split

      Subject to stockholder approval,  the Reverse Stock Split will be effected
by  filing  the  Reverse  Stock  Split  Amendment  to  the  Company's   Restated
Certificate  and will be effective  immediately  upon such filing.  Although the
Company  expects to file the Reverse  Stock Split  Amendment  with the  Delaware
Secretary of State's office promptly  following approval of this Proposal Two at
the Annual  Meeting,  the actual timing of such filing will be determined by the
Company's  management based upon their evaluation as to when such action will be
most advantageous to the Company and its stockholders.  The Company reserves the
right to forego or postpone  filing the Reverse  Stock Split  Amendment  if such
action  is  determined  to be in the  best  interests  of the  Company  and  its
stockholders.

      Each of the Company's stockholders will continue to own one or more shares
of Common  Stock and will  continue to share in the assets and future  growth of
the Company as a stockholder. Each stockholder that owns fewer than 20 shares of
Common  Stock  will have such  stockholder's  fractional  share of Common  Stock
converted into one share of Common Stock.  Each stockholder that owns 20 or more
shares of Common  Stock will own that number of shares as equals  1/20th as many
shares as such stockholder owned before the Reverse Stock Split,  subject to the
adjustment for fractional  shares,  in which case such stockholder shall receive
one share of Common Stock in lieu of such fractional share. The number of shares
of Common Stock that may be purchased upon the exercise of outstanding  options,
warrants,   and  other  securities  exercisable  for,  shares  of  Common  Stock
(collectively,   "Exercisable   Securities")  and  the  per  share  exercise  or
conversion  prices thereof,  will be adjusted  appropriately as of the Effective
Date, so that the aggregate number of shares of Common Stock issuable in respect
of  Exercisable  Securities  immediately  following the  Effective  Date will be
1/20th of the  number  issuable  in  respect  thereof  immediately  prior to the
Effective Date, the per share exercise price immediately following the Effective
Date will be 20 times the per share  exercise or  conversion  price  immediately
prior to the Effective  Date,  and the aggregate  exercise or conversion  prices
thereunder shall remain  unchanged.  The Reverse Stock Split will have no effect
on the authorized or outstanding  shares of Series A Preferred  Stock,  Series C
Preferred Stock and Series D Preferred Stock.

      The Reverse Stock Split will also result in some stockholders  owning "odd
lots" of less  than 100  shares  of  Common  Stock  received  as a result of the
Reverse Stock Split.  Brokerage  commissions  and other costs of transactions in
odd lots may be higher,  particularly  on a  per-share  basis,  than the cost of
transactions in even multiples of 100 shares.

     The Company is currently  authorized to issue  70,000,000  shares of Common
Stock,  par value $0.001 per share, of which  40,745,876  shares were issued and
outstanding  at the close of business on April 15, 1999,  the record  date.  The
Company is also authorized to issue 2,000,000  shares of Preferred  Stock,  each
share having a par value of $0.001 per share (the  "Preferred  Stock),  of which
400,000  shares of the  Company's  Series A  Preferred  Stock were  outstanding,
115,958 shares of the Company's  Series C Preferred  Stock were  outstanding and
2,016 shares of Series D Preferred Stock were outstanding.

     Adoption of the Reverse  Stock Split will reduce the shares of Common Stock
outstanding   on  April  15,  1999,  the  record  date,   from   40,745,876   to
approximately  2,037,294 but will not affect the number of authorized  shares of
Common Stock or the authorized or outstanding  shares of Preferred Stock.  After
the Reverse Stock Split, the Company  estimates that it will have  approximately
the same number of  stockholders.  Except for changes  resulting  in rounding of
fractional  shares,  the Reverse  Stock Split will not affect any  stockholder's
proportionate equity interest in the Company.

                                       9
<PAGE>

      The Common  Stock is currently  listed on the Nasdaq OTC  Bulletin  Board,
under the trading symbol SHMN.

Exchange of Stock Certificates

      The combination and reclassification of shares of Common Stock pursuant to
the Reverse Stock Split will occur  automatically  on the Effective Date without
any action on the part of  stockholders of the Company and without regard to the
date certificates representing shares of Common Stock prior to the Reverse Stock
Split are physically  surrendered for new certificates.  If the number of shares
of Common  Stock to which a holder is entitled as a result of the Reverse  Stock
Split  would  otherwise  include  a  fraction,  the  Company  will  issue to the
stockholder,  in lieu of issuing fractional shares of the Company,  one share of
Common Stock.

      As soon as practicable after the Effective Date, transmittal forms will be
mailed to each holder of record of certificates for shares of Common Stock to be
used in forwarding such certificates for surrender and exchange for certificates
representing  the number of shares of Common Stock such  stockholder is entitled
to receive as a consequence of the Reverse Stock Split.  The  transmittal  forms
will be accompanied by  instructions  specifying  other details of the exchange.
Upon receipt of such  transmittal  form, each  stockholder  should surrender the
certificates  representing  shares of Common  Stock prior to the  Reverse  Stock
Split,  in  accordance  with  the  applicable  instructions.   Each  holder  who
surrenders  certificates  will receive new  certificates  representing the whole
number of shares of Common Stock that he or she holds as a result of the Reverse
Stock Split.  STOCKHOLDERS  SHOULD NOT SEND THEIR STOCK  CERTIFICATES UNTIL THEY
RECEIVE A TRANSMITTAL FORM.

      After the Effective Date, each certificate  representing  shares of Common
Stock outstanding prior to the Effective Date (an "Old Certificate") will, until
surrendered  and  exchanged as described  above,  be deemed,  for all  corporate
purposes,  to evidence  ownership  of the whole number of shares of Common Stock
into which the shares of Common Stock  evidenced by such  certificate  have been
converted by the Reverse Stock Split, except that the holder of such unexchanged
certificates   will  not  be  entitled  to  receive  any   dividends   or  other
distributions  payable by the  Company  after the  Effective  Date until the Old
Certificates have been surrendered.  Such dividends and  distributions,  if any,
will be accumulated,  and at the time of surrender of the Old Certificates,  all
such unpaid dividends or distributions will be paid without interest.

Certain Federal Income Tax Considerations

      The following  discussion  describes  certain  material federal income tax
considerations  relating to the Reverse  Stock Split.  This  discussion is based
upon the Internal  Revenue Code of 1986, as amended (the  "Code"),  existing and
proposed regulations thereunder,  legislative history,  judicial decisions,  and
current  administrative  rulings and practices,  all as amended and in effect on
the date  hereof.  Any of these  authorities  could be repealed,  overruled,  or
modified at any time.  Any such change could be  retroactive  and,  accordingly,
could cause the tax  consequences to vary  substantially  from the  consequences
described  herein.  No ruling from the Internal Revenue Service (the "IRS") with
respect to the  matters  discussed  herein has been  requested,  and there is no
assurance  that the IRS  would  agree  with the  conclusions  set  forth in this
discussion.

      This discussion may not address  certain  federal income tax  consequences
that may be  relevant  to  particular  stockholders  in light of their  personal
circumstances  (such as persons  subject to the  alternative  minimum tax) or to
certain  types  of  stockholders  (such  as  dealers  in  securities,  insurance
companies,  foreign  individuals  and  entities,  financial  institutions,   and
tax-exempt  entities) who may be subject to special  treatment under the federal
income tax laws.  This  discussion  also does not address  any tax  consequences
under state, local or foreign laws.

      STOCKHOLDERS  ARE URGED TO CONSULT THEIR TAX ADVISORS AS TO THE PARTICULAR
TAX   CONSEQUENCES   OF  THE  REVERSE  STOCK  SPLIT  FOR  THEM,   INCLUDING  THE
APPLICABILITY OF ANY STATE, LOCAL OR FOREIGN TAX LAWS, CHANGES IN APPLICABLE TAX
LAWS AND ANY PENDING OR PROPOSED LEGISLATION.

      The  Company  should  not  recognize  any gain or loss as a result  of the
Reverse Stock Split.  No gain or loss should be recognized by a stockholder  who
receives  only Common Stock upon the Reverse  Stock  Split.  A  stockholder  who


                                       10
<PAGE>

receives one share of Common Stock in lieu of a fractional share of Common Stock
that otherwise would be held as a capital asset generally will recognize capital
gain or loss in an amount equal to the difference  between the cash value of the
one  share  of  Common  Stock  received  and  the  stockholder's  basis  in such
fractional  share of Common Stock.  For this purpose,  a stockholder's  basis in
such  fractional  share of Common Stock will be determined as if the stockholder
actually  received  such  fractional  share.  Except as provided with respect to
fractional shares, the aggregate tax basis of the shares of Common Stock held by
a stockholder  following  the Reverse  Stock Split will equal the  stockholder's
aggregate basis in the Common Stock held immediately  prior to the Reverse Stock
Split and  generally  will be  allocated  among the shares of Common  Stock held
following the Reverse  Stock Split on a pro-rata  basis.  Stockholders  who have
used the  specific  identification  method to identify  their basis in shares of
Common Stock  combined in the Reverse  Stock Split should  consult their own tax
advisors to  determine  their basis in the  post-Reverse  Stock Split  shares of
Common Stock received in exchange therefor.

Required Vote

      The  affirmative  vote of a majority of the Company's  outstanding  voting
shares is required to approve the  amendment  and  restatement  of the Company's
Restated Certificate to effect the Reverse Stock Split.

Recommendation of the Board of Directors

      The Board of Directors  recommends that the stockholders  vote IN FAVOR OF
the amendment and  restatement of the Company's  Restated  Certificate to effect
the Reverse  Stock Split.  The purpose of the Reverse  Stock Split is to combine
the  outstanding  shares of the  Company's  Common Stock so that the Company has
adequate  authorized but unissued  shares of Common Stock available for issuance
upon the  conversion  of several  Series of Preferred  Stock.  If shares are not
available to accommodate conversion of the Series C Preferred Stock and Series D
Preferred Stock when requested, the Company will be in breach of its obligations
and therefore will face significant  penalties under the agreements  relating to
the  issuance  of such  securities  and may  entitle the holders of the Series C
and/or  Series D Preferred  Stock to have their shares  redeemed  for cash.  The
Company does not have the financial resources to redeem such shares.



                                       11
<PAGE>

                                 PROPOSAL THREE

                          AMENDMENT AND RESTATEMENT OF
                AMENDED AND RESTATED CERTIFICATE OF INCORPORATION
                   TO INCREASE THE NUMBER OF PREFERRED SHARES


                             AUTHORIZED FOR ISSUANCE



     The present capital structure of the Company authorizes 2,000,000 shares of
Preferred  Stock,  par value $0.001 per share (the  "Preferred  Stock").  Of the
2,000,000 shares of Preferred Stock authorized, 400,000 shares are designated as
Series A  Preferred  Stock,  all of which are  issued and  outstanding,  200,000
shares are designated as Series C Preferred  Stock,  115,958 of which are issued
and  outstanding,  and 6,285 shares are designated as Series D Preferred  Stock,
2,016 of which are issued  and  outstanding.  The Board  believes  this  capital
structure  is  inadequate  for the  present  and  future  needs of the  Company.
Therefore,  the Board has unanimously  approved the amendment and restatement of
the Company's Restated Certificate to increase the number of shares of Preferred
Stock  authorized for issuance  under Article IV of the Restated  Certificate by
10,000,000  shares,  from  2,000,000  shares  to  12,000,000  shares.  The Board
believes  this capital  structure  more  appropriately  reflects the present and
future  needs of the  Company and  recommends  that the  Company's  stockholders
approve such amendment and  restatement.  The Preferred Stock may be issued from
time to time in one or more series with such rights, preferences and privileges,
including  dividend rates,  conversion and redemption prices, and voting rights,
as may be determined by the Board.

     If approved by the Company's  stockholders as provided herein, the increase
in shares of Preferred Stock will be effected by an amendment and restatement of
the Company's  Restated  Certificate in substantially  the form attached to this
Proxy Statement as Appendix A (the  "Preferred  Increase  Amendment"),  and will
become  effective upon the filing of the Preferred  Increase  Amendment with the
Secretary  of State  of  Delaware.  The  Amended  and  Restated  Certificate  of
Incorporation  attached hereto as Appendix A includes the amendment set forth in
this Proposal Three and the amendments set forth in Proposals 2, 4 and 5 of this
Proxy  Statement.  Only the  amendments  approved  by the  stockholders  will be
included  in the  Restated  Certificate  of  Incorporation  as  filed  with  the
Secretary  of State of  Delaware.  The following  discussion is qualified in its
entirety  by the  full  text  of the  Preferred  Increase  Amendment,  which  is
incorporated by reference herein.

Purpose of Authorizing Additional and Preferred Stock

     The  authorization of an additional  10,000,000  shares of Preferred Stock
would  give the Board  the  express  authority,  without  further  action of the
stockholders, to issue such shares of Common Stock and Preferred Stock from time
to time as the Board deems necessary. The Board believes it is necessary to have
the ability to issue such  additional  shares of Preferred Stock primarily to be
able to complete the Company's  proposed Rights Offering.  The 10,000,000 shares
of Preferred  Stock should be sufficient to  accommodate  the Series R Preferred
Stock that the Company  plans to issue in  connection  with the proposed  Rights
Offering.  The Company  intends to use the proceeds from the Rights  Offering to
fund ongoing  operations  of its  Botanicals  business,  including  research and
development and commercialization activities, and for general corporate purposes
and also  believes  the Rights  Offering  is the only way the  holders of Common
Stock can  mitigate  the  dilution  potential  of the  holders  of the  Series C
Preferred Stock.

      The  additional  Preferred  Stock would be  available  for issuance by the
Board  without  future  action  by the  stockholders,  unless  such  action  was
specifically  required  by  applicable  law or rules of any  stock  exchange  or
quotation system on which the Company's securities may then be listed.

Effect of Authorizing Additional Preferred Stock

      The  Board of  Directors  of the  Company  believes  the  increase  in the
authorized  shares is necessary to provide the Company with the  flexibility  to
act in the future with respect to  financing  programs,  including  the proposed
Rights Offering, acquisitions and other corporate purposes without the delay and
expense  associated  with obtaining  special  stockholder  approval each time an
opportunity requiring the issuance of shares may arise.

                                       12
<PAGE>

      The  proposed  increase in the  authorized  number of shares of  Preferred
Stock  could have a number of effects on the  Company's  stockholders  depending
upon the exact nature and  circumstances  of any actual  issuances of authorized
but unissued shares.  The increase could have an anti-takeover  effect,  in that
additional  shares could be issued (within the limits imposed by applicable law)
in one or more  transactions  that could make a change in control or takeover of
the Company more difficult.  For example,  additional  shares could be issued by
the  Company so as to dilute  the stock  ownership  or voting  rights of persons
seeking to obtain control of the Company.  Similarly, the issuance of additional
shares to certain  persons allied with the Company's  management  could have the
effect of making it more difficult to remove the Company's current management by
diluting the stock  ownership or voting rights of persons  seeking to cause such
removal.

      In addition, an issuance of additional shares by the Company could have an
effect on the potential realizable value of a stockholder's  investment.  In the
absence of a proportionate increase in the Company's earnings and book value, an
increase in the aggregate number of outstanding  shares of the Company caused by
the  issuance of the  additional  shares would dilute the earnings per share and
book value per share of all outstanding  shares of the Company's  capital stock.
If such  factors  were  reflected  in the price per share of Common  Stock,  the
potential  realizable  value of a  stockholder's  investment  could be adversely
affected.

      The Company  currently  has no plans to issue  shares of  Preferred  Stock
beyond the Rights Offering.

Vote Required for Stockholder Approval

      The  affirmative  vote of (a) a majority  of all  shares of the  Company's
Common  Stock,  including  all  shares of  Series A  Preferred  Stock,  Series C
Preferred Stock and Series D Preferred Stock and (b) a majority of shares of the
Series A Preferred  Stock  Preferred  C,  Series C Preferred  Stock and Series D
Preferred Stock, voting separately as a class, outstanding at the time of voting
is required  for  approval of the  amendment  and  restatement  of the  Restated
Certificate  to increase  the number of  authorized  shares of  Preferred  Stock
issuable  thereunder by 10,000,000  shares,  from 2,000,000 shares to 12,000,000
shares.

Recommendation of the Board of Directors

     The Board of Directors  recommends that the  stockholders  vote IN FAVOR OF
the  amendment and  restatement  of the Company's  Restated  Certificate.  These
additional  shares of  Preferred  Stock are  expected to be used to complete the
Company's  proposed  Rights  Offering to its current  stockholders.  The Company
believes that the Rights  Offering is the best way the current holders of Common
Stock  can be  protected  from the  potential  dilution  of  currently  existing
Preferred Stock.



                                       13
<PAGE>


                                  PROPOSAL FOUR

                          AMENDMENT AND RESTATEMENT OF
                AMENDED AND RESTATED CERTIFICATE OF INCORPORATION
                     TO INCREASE THE NUMBER OF COMMON SHARES


                             AUTHORIZED FOR ISSUANCE


     The present capital structure of the Company  authorizes  70,000,000 shares
of  Common  Stock,  par value  $0.001  per  share.  Of the  2,000,000  shares of
Preferred Stock authorized,  400,000 shares are designated as Series A Preferred
Stock, all of which are issued and outstanding, 200,000 shares are designated as
Series C Preferred Stock, 115,958 of which are issued and outstanding, and 6,285
shares are designated as Series D Preferred Stock, 2,016 of which are issued and
outstanding.  The Board  believes this capital  structure is inadequate  for the
present and future needs of the Company.  Therefore,  the Board has  unanimously
approved the amendment and restatement of the Company's Restated  Certificate to
increase the number of shares of Common  Stock  authorized  for  issuance  under
Article IV of the Restated  Certificate by 150,000,000  shares,  from 70,000,000
shares  to  220,000,000.   The  Board  believes  this  capital   structure  more
appropriately  reflects  the  present  and  future  needs  of  the  Company  and
recommends   that  the  Company's   stockholders   approve  such  amendment  and
restatement.   On  April  15,  1999,  2,037,294  shares  of  Common  Stock  were
outstanding(taking  into account the effect of the 20-for-1  reverse stock split
described in Proposal  Two). On April 15, 1999,  assuming the  conversion of the
outstanding shares of the Company's Series A Preferred Stock, Series C Preferred
Stock and Series D Preferred Stock and exercise of all outstanding  warrants and
options,  approximately  202,941,267 shares of Common Stock would be outstanding
on a fully diluted basis (taking into account the effect of the 20-for-1 reverse
stock split described in Proposal Two).

     If approved by the Company's  stockholders as provided herein, the increase
in shares of Common Stock will be effected by an amendment  and  restatement  of
the Company's  Restated  Certificate in substantially  the form attached to this
Proxy Statement as Appendix A (the "Common Increase Amendment"), and will become
effective upon the filing of the Common Increase Amendment with the Secretary of
State of  Delaware.  The  Amended  and  Restated  Certificate  of  Incorporation
attached  hereto as Appendix A includes the amendment set forth in this Proposal
Four  and the  amendments  set  forth  in  Proposals  2, 3 and 5 of  this  Proxy
Statement.  Only the amendments approved by the stockholders will be included in
the Restated  Certificate of  Incorporation as filed with the Secretary of State
of Delaware.  The following  discussion is qualified in its entirety by the full
text of the  Common  Increase  Amendment,  which is  incorporated  by  reference
herein.

Purpose of Authorizing Additional Common Stock

      The  authorization  of an  additional  150,000,000  shares of Common Stock
would  give the Board  the  express  authority,  without  further  action of the
stockholders,  to issue  such  shares of Common  Stock  from time to time as the
Board deems necessary. The Board believes it is necessary to have the ability to
issue such  additional  shares of Common  Stock  primarily  to  accommodate  the
proposed  Rights  Offering.  The  Company  expects  to issue  shares of Series R
Preferred  Stock in connection  with its proposed Rights Offering to its current
stockholders, and the Company must have a significant number of shares of Common
Stock  available  for  issuance  upon  conversion  of such  shares  of  Series R
Preferred Stock into Common Stock.  If  insufficient  shares of Common Stock are
available for conversion of the Series R Preferred Stock,  there will be limited
liquidity for the holder of the Preferred Stock.

      Additionally, it is important that the Company has adequate authorized but
unissued  shares of Common Stock  available for issuance upon the  conversion of
several  Series of Preferred  Stock.  If shares are not available to accommodate
conversion  of the Series C Preferred  Stock and Series D  Preferred  Stock when
requested,  the Company will be in breach of its  obligations and therefore will
face significant penalties under the agreements relating to the issuance of such
securities and may entitle the holders of the Series C and/or Series D Preferred
Stock to have their  shares  redeemed  for cash.  The Company  does not have the
financial  resources to redeem such shares. 

                                       14
<PAGE>

      The additional  Common Stock would be available  for issuance by the Board
without future action by the  stockholders,  unless such action was specifically
required by applicable law or rules of any stock exchange or quotation system on
which the Company's securities may then be listed.

Effect of Authorizing Additional Common Stock

      The Board of Directors  believes the increase in the authorized  shares is
necessary to provide the Company with the  flexibility to act in the future with
respect to financings,  including the proposed Rights Offering, acquisitions and
other corporate purposes without the delay and expense associated with obtaining
special stockholder approval each time an opportunity  requiring the issuance of
shares may arise.

      An issuance of  additional  shares by the Company  could have an effect on
the potential realizable value of a stockholder's  investment. In the absence of
a proportionate  increase in the Company's  earnings and book value, an increase
in the  aggregate  number of  outstanding  shares of the  Company  caused by the
issuance of the  additional  shares would dilute the earnings per share and book
value per share of all  outstanding  shares of the Company's  capital stock.  If
such  factors  were  reflected  in the  price per  share of  Common  Stock,  the
potential  realizable  value of a  stockholder's  investment  could be adversely
affected.

Vote Required for Stockholder Approval

      The  affirmative  vote of a majority of the Company's  outstanding  voting
shares is required to approve the  amendment  and  restatement  of the  Restated
Certificate to increase the number of authorized shares of Common Stock issuable
thereunder by 150,000,000 shares, from 70,000,000 shares to 220,000,000 shares

Recommendation of the Board of Directors

     The Board of Directors  recommends that the  stockholders  vote IN FAVOR OF
the amendment and restatement of the Company's Restated Certificate. The Company
expects  to issue  shares of Series R  Preferred  Stock in  connection  with its
proposed Rights Offering, to its current stockholders, and the Company must have
a  significant  number of shares of Common Stock  available  for  issuance  upon
conversion  of such shares of Series R Preferred  Stock into  Common  Stock.  If
sufficient shares of Common Stock are not available for conversion of the Series
R Preferred  Stock,  there may be limited liquidity for  the Series R Preferred 
Stockholders.

      Additionally, it is important that the Company has adequate authorized but
unissued  shares of Common Stock  available for issuance upon the  conversion of
several  Series of Preferred  Stock.  If shares are not available to accommodate
conversion  of the Series C Preferred  Stock and Series D  Preferred  Stock when
requested,  the Company will be in breach of its  obligations and therefore will
face significant penalties under the agreements relating to the issuance of such
securities and may entitle the holders of the Series C and/or Series D Preferred
Stock to have their  shares  redeemed  for cash.  The Company  does not have the
financial resources to redeem such shares.




                                       15
<PAGE>


                                  PROPOSAL FIVE

                          AMENDMENT AND RESTATEMENT OF
              AMENDED AND RESTATED CERTIFICATE OF INCORPORATION
               TO AMEND CERTAIN LIQUIDATION PREFERENCE RIGHTS
                               OF PREFERRED STOCK


     The Board of Directors has approved a proposal to amend Article IV, Section
B.5(e) of the Company's Restated Certificate to (i) delete the provision stating
that a transaction  or series of  transactions  in which in excess of 50% of the
Company's  voting  power  is  transferred  will  be  treated  as a  liquidation,
dissolution  or winding up of the Company,  and (ii) delete the reference to the
Series D Preferred Stock from the section,  since the section, as amended,  will
no longer apply to the Series D Preferred  Stock.  If approved by the  Company's
stockholders  as  provided  herein,  the  amendment  to Section  B.5(e)  will be
effected by an amendment to Section B.5(e) of the Company's Restated Certificate
in  substantially  the form attached to this Proxy Statement as Appendix A which
will become  effective  upon the filing of the  amendment  with the Secretary of
State of Delaware.  The following discussion is qualified in its entirety by the
full text of the  amendment,  which is  incorporated  by reference  herein.  The
Amended and Restated Certificate of Incorporation  attached hereto as Appendix A
includes the amendment set forth in this  Proposal Five and the  amendments  set
forth in  Proposals  2, 3 and 4 of this  Proxy  Statement.  Only the  amendments
approved by the  stockholders  will be included in the Restated  Certificate  of
Incorporation as filed with the Secretary of State of Delaware.  

Currently, this section of the Restated Certificate provides as follows:

      "With respect to the Series A Preferred  Stock,  Series C Preferred  Stock
and  Series D  Preferred  Stock  (except  as  limited  with  respect to Series D
Preferred Stock as set forth in Section 5(b) above),  (i) any acquisition of the
Corporation  by means of merger or other  form of  corporate  reorganization  in
which  outstanding  shares of the  Corporation  are exchanged for  securities or
other consideration issued, or caused to be issued, by the acquiring corporation
or its subsidiary (other than a mere reincorporation transaction) or (ii) a sale
of all or substantially  all of the assets of the Corporation or (iii) any other
transaction  or series of related  transactions  by the  Corporation in which in
excess of 50% of the Corporation's voting power is transferred, shall be treated
as a liquidation, dissolution or winding up of the Corporation and shall entitle
the  holders of the Series C  Preferred  Stock and Series A  Preferred  Stock to
receive at the  closing  thereof  the amount as  specified  in Section  5(a) and
Section 5(c), respectively."

      The stockholders are being asked to vote on a proposal to delete subclause
(iii) of this section.  The effect of this amendment would be that  transactions
by the  Company  in  which  more  than  50% of the  Company's  voting  stock  is
transferred  would  not  be  treated  as a  liquidation  event,  and  that  such
transactions  would  therefore not result in a requirement  that the liquidation
preference  amounts of the preferred  stock be distributed to the holders of the
preferred  stock.  The deletion of subclause  (iii) will make the  provisions of
Section B.5(e)  inapplicable to the Series D Preferred  Stock,  since subclauses
(i) and (ii), which provide that mergers and other reorganizations, and sales of
the Company's assets,  shall be deemed to be liquidation events, do not apply to
the Series D  Preferred  Stock in any  event,  pursuant  to section  5(b) of the
Restated Certificate.  The amendment to delete the Series D Preferred Stock from
the section is  therefore  intended  to clarify  that the section is intended to
apply only to Series A Preferred Stock and Series C Preferred Stock.

Reasons for the Amendments

      The  proposed  amendments  would  avoid  having a change in control of the
Company involving the transfer of over 50% of the Company's voting power cause a
liquidation event under the Restated  Certificate that would require the Company
to distribute to the holders of the preferred stock their liquidation preference
amounts.  Since it is possible that the proposed Rights Offering could result in
such a change in control of the  Company,  the Company  could be required to pay
the liquidation amounts in cash to its preferred stockholders upon completion of
the Rights  Offering.  The Company does not have the financial  resources to pay
the  liquidation  preference  amounts,  and  any  such  required  payment  would
therefore be detrimental to the Company and its  stockholders.  The  possibility
that the Rights Offering could result in requiring the Company to distribute the


                                       16
<PAGE>

preferred stockholders'  liquidation preference amounts could make it impossible
to proceed with the Rights Offering or any similar  financing  transaction,  and
the Board believes it is necessary and in the best interests of its stockholders
to avoid this possibility.

      In addition,  since the Restated Certificate currently provides that, with
respect to the Series D Preferred Stock,  mergers and other  reorganizations and
sales of the  Company's  assets  shall not in and of  themselves  be  considered
liquidation  events,  the  elimination  of  subclause  (iii) in effect makes the
entire section inapplicable to the Series D Preferred Stock, and the deletion of
the Series D Preferred  Stock from the  section is intended to clarify  that the
section is intended to apply only to the Series A and Series C Preferred Stock.

Vote Required for Stockholder Approval

      The affirmative vote of (a) a majority of all of the Company's outstanding
voting shares,  including all shares of Common Stock,  Series A Preferred Stock,
Series C Preferred  Stock and Series D  Preferred  Stock,  voting  together as a
single class,  and (b) a majority of the shares of the Series A Preferred Stock,
Series C Preferred Stock and Series D Preferred Stock, each voting as a separate
series,  is required to approve the  amendments of the Restated  Certificate  to
delete   subclause   (iii)  of  Article  IV,  Section  B.5(e)  of  the  Restated
Certificate,  which  provides that a transaction  or series of  transactions  in
which in excess of 50% of the  Company's  voting  power is  transferred  will be
treated as a  liquidation,  dissolution  or winding  up of the  Company,  and to
delete the reference to the Series D Preferred Stock from the section.

Recommendation of the Board of Directors

      The Board of Directors  recommends a vote IN FAVOR OF this  proposal.  The
possibility  that the Rights  Offering  could result in requiring the Company to
distribute the preferred stockholders' liquidation preference amounts could make
it  impossible  to proceed  with the Rights  Offering or any  similar  financing
transaction,  since the Company does not have the financial resources to pay the
liquidation preference amounts.


                                       17
<PAGE>




                                  PROPOSAL SIX

                       AMENDMENT TO 1992 STOCK OPTION PLAN

Introduction

     EXCEPT AS OTHERWISE  STATED IN THIS  PROPOSAL  SIX,  ALL SHARE  NUMBERS AND
EXERCISE  PRICES  REFLECT THE APPROVAL OF THE REVERSE STOCK SPLIT AND THE FILING
OF  THE  REVERSE  STOCK  SPLIT  AMENDMENT,  AND  ARE  THEREFORE  REFLECTED  ON A
POST-REVERSE STOCK SPLIT BASIS.

      The stockholders are being asked to vote on a proposal to approve a series
of amendments to the Company's 1992 Stock Option Plan (the "1992 Plan) the Board
adopted  on March 15,  1999,  subject  to  stockholders  approval  at the Annual
Meeting.  The  amendments  will effect the  following  principal  changes to the
existing provisions of the 1992 Plan:

      (i)  increase the maximum  number of shares of the Company's  Common Stock
           issuable  over the term of the 1992 Plan by an  additional  6,689,167
           shares so that the number of shares  reserved for future option grant
           under the 1992 Plan,  when  added to the number of shares  subject to
           outstanding options, will equal 7,000,000 shares;

      (ii) effective  as of February  1, 2000,  increase  the maximum  number of
           shares of  Common  Stock  issuable  over the term of the 1992 Plan by
           that number of additional  shares which,  when added to the number of
           shares  subject to then  outstanding  options under the 1992 Plan and
           the number of shares available for future option grant under the 1992
           Plan immediately prior to that increase, will equal the lesser of (a)
           25,000,000  shares or (b) twenty  percent (20%) of the sum of (i) the
           number of voting shares of the Company's capital stock outstanding at
           that time plus (ii) the number of shares of Common  Stock  subject to
           the then  outstanding  options  under the 1992  Plan  plus  (iii) the
           number of shares  available  for future  option  grant under the 1992
           Plan (after taking such increase into account);

      (iii)implement an automatic share increase  feature  pursuant to which the
           number of shares of Common Stock  available  for  issuance  under the
           1992 Plan will  automatically  increase  on the first  trading day of
           January each  calendar  year,  beginning  with calendar year 2001 and
           continuing  through  calendar  year 2008,  by an amount equal to four
           percent  (4%) of the total number of shares  outstanding  on the last
           trading day of the  immediately  preceding  calendar  year, but in no
           event  will  any  such  annual  increase  exceed  the  lesser  of (a)
           5,000,000  shares or (b) that number of  additional  shares needed so
           that the number of shares  available  for future grant under the 1992
           Plan (after  taking that annual  increase into  account)  will,  when
           added  to the  number  of  shares  subject  to the  then  outstanding
           options,  equal twenty  percent (20%) of the sum of (i) the number of
           voting shares of the Company's capital stock outstanding at that time
           plus (ii) the  number of shares of Common  Stock  subject to the then
           outstanding  options  under the 1992 Plan  plus  (iii) the  number of
           shares available for future option grant under the 1992 Plan;

      (iv) increase  the  limitation  on the maximum  number of shares of Common
           Stock for which any one  individual  may be granted stock options and
           separately  exercisable stock  appreciation  rights per calendar year
           from 125,0000 shares to 5,000,000 shares:

      (v)  extend the term of the 1992 Plan so that the 1992 Plan will terminate
           on December 31, 2008; and


                                       18
<PAGE>

      (vi) revise  the  Automatic   Option  Grant  Program  in  effect  for  the
           non-employee Board members to eliminate the annual stock option grant
           feature of that program and to provide  instead the  following  stock
           option  grants:  (a) a one-time  option  grant on February 1, 2000 to
           each individual  serving as a non-employee Board member on that date,
           with each such grant to have an exercise price per share equal to the
           fair market  value per share of Common Stock on the grant date and to
           cover that number of shares of Common  Stock equal to one half of one
           percent  (0.5%)  of the  number of  voting  shares  of the  Company's
           capital  stock  outstanding  at that time and (b) a  one-time  option
           grant to each new  non-employee  Board  member  at the time he or she
           first joins the Board, with each such grant to have an exercise price
           per share equal to the fair market  value of the Common  Stock at the
           grant date and to cover the  same  number of shares of Common  Stock 
           for  which each  non-employee Board members is granted  an option  on
           February 1, 2000l.  Stockholders should be  advised that each  member
           of the Board of Directors has surrendered all of his or her currently
           outstanding options to purchase shares of the Company's Common Stock.
         
      The series of proposed share  increases~ to the 1992 Plan will assure that
a sufficient  reserve of Common  Stock will be available  under the 1992 Plan to
provide the Company with the continuing opportunity to utilize equity incentives
to attract  and retain the  services of  employees  essential  to the  Company's
long-term growth and financial  success.  The proposed revision to the Automatic
Option Grant Program is designed to provide a more meaningful  equity  incentive
to  attract  and  retain  the  services  of  highly  qualified  and  experienced
non-employee Board members.

      The  principal  terms and  provisions  of the 1992 Plan as modified by the
most recent  amendment,  are  summarized  below.  The  summary is not,  however,
intended to be a complete  description of all the terms of the 1992 Plan. A copy
of the actual plan document will be furnished  without charge to any stockholder
upon  written  request to the  attention  of the  Company's  Investor  Relations
Department at 213 East Grand Avenue, South San Francisco, CA 94080.

Description of the 1992 Plan

      Structure.  The 1992 Plan is divided  into two separate  equity  incentive
programs:  (i) a  Discretionary  Option Grant Program under which key employees,
non-employee  Board members and  consultants  may be granted options to purchase
shares of Common Stock at a fixed price per share and (ii) an  Automatic  Option
Grant Program under which eligible non-employee Board members will automatically
receive a special one-time option grant.

      Options granted under the Discretionary Option Grant Program may be either
incentive stock options  designed to meet the requirements of Section 422 of the
Internal  Revenue  Code or  non-statutory  options not  intended to satisfy such
requirements.  All grants  under the  Automatic  Option  Grant  Program  will be
non-statutory options.

      Administration.  The Discretionary Option Grant Program is administered by
the  Compensation  Committee of the Board (the  "Compensation  Committee" or the
"Plan Administrator"). Compensation Committee members are appointed by the Board
and may be removed by the Board at any time.

      The  Compensation  Committee  as Plan  Administrator  has full  authority,
subject  to  the  provisions  of  the  1992  Plan,  to  determine  the  eligible
individuals  who are to receive option grants and/or stock  appreciation  rights
under the  Discretionary  Option Grant  Program,  the type of option  (incentive
stock option or non-statutory  stock option) or stock appreciation right (tandem
or limited) to be  granted,  the number of shares to be covered by each  granted
option  or right,  the date or dates on which  the  option or right is to become
exercisable  and the  maximum  term for which  the  option or right is to remain
outstanding.

      All grants under the Automatic Option Grant Program will be made in strict
compliance with the express  provisions of that program,  and no  administrative
discretion will be exercised by the Plan Administrator.


                                       19
<PAGE>

      Eligibility.  Key  employees  (including  officers),   non-employee  Board
members,  and  consultants in the service of the Company are eligible to receive
option grants under the Discretionary  Option Grant Program.  Non-employee Board
members are also eligible to participate in the Automatic Option Grant Program.

     As of April 15, 1999 approximately  twenty eight (28) employees  (including
seven (7)  executive  officers)  and six (6)  non-employee  Board  members  were
eligible to participate in the Discretionary  Option Grant Program,  and the six
(6)  non-employee  Board  members  were  also  eligible  to  participate  in the
Automatic Option Grant Program.

     Securities  Subject to the 1992 Plan.  If this  Proposal is approved by the
stockholders,  then the number of shares of Common Stock  issuable over the term
of the 1992 Plan will be immediately  increased by 6,689,167 shares from 310,833
shares to  7,000,000  shares.  In addition,  on February 1, 2000,  the number of
shares of Common Stock issuable under the 1992 Plan will automatically  increase
by that number of shares  which,  when added to the number of shares  subject to
then outstanding  options under the 1992 Plan and the number of shares available
for future option grant under the 1992 Plan immediately  prior to such increase,
will equal the lesser of (a)  25,000,000  shares or (b) twenty  percent (20%) of
the sum of (i) the  number  of  voting  shares of the  Company's  capital  stock
outstanding  at that time plus (ii) the number of shares of Common Stock subject
to the then  outstanding  options  under the 1992 Plan plus  (iii) the number of
shares  available for future option grant under the 1992 Plan (after taking such
increase into account).

      The share reserve under the 1992 Plan will  automatically  increase on the
first trading day of January each calendar  year,  beginning  with calendar year
2001 and  continuing  through  calendar  year 2008,  by an amount  equal to four
percent (4%) of the total number of shares  outstanding  on the last trading day
of the immediately preceding calendar year, but in no event will any such annual
increase  exceed  the  lesser  of (a)  5,000,000  shares  or (b) that  number of
additional shares needed so that the number of shares available for future grant
under the 1992 Plan (after taking that annual  increase into account) will, when
added to the number of shares  subject to the then  outstanding  options,  equal
twenty  percent  (20%) of the sum of (i) the  number  of  voting  shares  of the
Company's  capital stock outstanding at that time plus (ii) the number of shares
of Common Stock subject to the then outstanding options under the 1992 Plan plus
(iii) the number of shares  available  for future  option  grant  under the 1992
Plan.

      The shares issuable under the 1992 Plan may be made available  either from
the  authorized  but  unissued  shares of Common  Stock or from shares of Common
Stock repurchased by the Company, including shares purchased on the open market.

     As of April 15, 1999,  approximately 27,571 shares of Common Stock had been
issued  under the 1992 Plan,  207,018  shares of Common  Stock  were  subject to
outstanding  options,  and 6,765,411  shares of Common Stock were  available for
future option grant,  taking into account the initial  6,689,167-share  increase
which forms part of this Proposal Six.

      If this Proposal is approved by the stockholders,  then the maximum number
of shares of Common Stock for which any one individual participating in the 1992
Plan be granted  stock  options or  separately  exercisable  stock  appreciation
rights  per  calendar  year,  beginning  with the 1999  calendar  year,  will be
increased  from  125,000  shares  to  5,000,000  shares.   The   5,000,000-share
limitation will be subject to adjustment from time to time.

      Should an option  expire or terminate  for any reason prior to exercise in
full,  the shares  subject to the portion of the option not so exercised will be
available for subsequent grant under the 1992 Plan. In addition, unvested shares
issued under the 1992 Plan and  subsequently  repurchased  by the Company at the
option exercise price paid per share will be added back to the share reserve and
will  accordingly  be available  for  subsequent  issuance  under the 1992 Plan.
However,  shares  subject to any option  surrendered  or cancelled in accordance
with the  stock  appreciation  right  provisions  of the 1992  Plan  will not be
available for subsequent grants.

Discretionary Option Grant Program

      Price  and  Exercisability.  The  option  exercise  price  per  share  for
incentive  stock option grants may not be less than the fair market value of the
Common Stock on the grant date. The exercise  price per share for  non-statutory
option grants may be less than,  equal to or greater than such fair market value
of the date of grant.  Options  granted  under the  Discretionary  Option  Grant



                                       20
<PAGE>

Program  may  either  become  exercisable  in  periodic  installments  over  the
optionee's  period of service or may be immediately  exercisable  for all of the
option  shares,  with such shares  subject to repurchase by the Company,  at the
exercise  price paid per share,  in the event the optionee  leaves the Company's
service prior to vesting in those shares.  No granted option will have a term in
excess of 10 years from the date of grant.

      The  exercise  price may be paid in cash or in  shares  of  Common  Stock.
Options may also be exercised through a same-day sale program, pursuant to which
a designated  brokerage firm effects the immediate sale of the shares  purchased
under  the  option  and  pays  over to the  Company,  out of the  sale  proceeds
available on the settlement  date,  sufficient funds to cover the exercise price
for the  purchased  shares  plus  all  applicable  withholding  taxes.  The Plan
Administrator  may also  assist  any  optionee  (including  an  officer)  in the
exercise of his or her outstanding  options by (a) authorizing a Company loan to
the  optionee  or (b)  permitting  the  optionee  to pay the  exercise  price in
installments  over a period of years.  The terms and conditions of any such loan
or installment payment will be established by the Plan Administrator in its sole
discretion,  but in no event may the maximum  credit  extended  to the  optionee
exceed the aggregate  exercise price payable for the purchased shares,  plus any
federal or state income or  employment  taxes  incurred in  connection  with the
purchase.

      Valuation.  For purposes of  establishing  the exercise  price and for all
other valuation purposes under the 1992 Plan, the fair market value per share of
Common  Stock on any relevant  date will be deemed equal to the closing  selling
price per share on that  date,  as such  price is  reported  on the  Nasdaq  OTC
Bulletin  Board.  The  closing  price of the Common  Stock on April 15, 1999 was
$0.065 per share.

      Termination  of Service.  Any option  held by the  optionee at the time of
cessation of service will not remain exercisable beyond the limited post-service
period  designated  by the Plan  Administrator  at the time of the option grant.
Under no circumstances, however, may any option be exercised after the specified
expiration date of the option term. Each such option will normally,  during such
limited  period,  be  exercisable  only to the extent of the number of shares of
Common Stock for which the option is  exercisable  at the time of the optionee's
cessation of service.  The optionee will be deemed to continue in service for so
long as such  individual  performs  services  for the  Company (or any parent or
subsidiary  corporation),  whether as an employee,  a non-employee member of the
Board or an independent consultant or advisor.

      The Plan  Administrator  has  complete  discretion  to extend  the  period
following  the  optionee's   cessation  of  service  during  which  his  or  her
outstanding  options may be exercised and/or to accelerate the exercisability or
vesting of such options in whole or in part. Such discretion may be exercised at
any time  while the  options  remain  outstanding,  whether  before or after the
optionee's actual cessation of service.

      Stockholder  Rights.  No optionee is to have any  stockholder  rights with
respect to the option  shares until the optionee  has  exercised  the option and
paid the exercise  price for the  purchased  shares.  Options are  generally not
assignable or  transferable  other than by will or the laws of inheritance  and,
during  the  optionee's  lifetime,  the  option  may be  exercised  only by such
optionee.  However, the Plan Administrator may allow non-statutory options to be
transferred or assigned during the optionee's lifetime to one or more members of
the optionee's immediate family or to a trust established exclusively for one or
more such family  members,  to the extent  such  transfer  or  assignment  is in
furtherance of the optionee's estate plan.

      Repurchase  Rights.  The shares of Common Stock acquired upon the exercise
of one or more  options  may be subject to  repurchase  by the  Company,  at the
original exercise price paid per share, upon the optionee's cessation of service
prior to vesting in those shares. The Plan Administrator has complete discretion
in  establishing  the  vesting  schedule  to be in effect for any such  unvested
shares and may cancel the Company's  outstanding  repurchase rights with respect
to those  shares at any time,  thereby  accelerating  the  vesting of the shares
subject to the cancelled rights.



                                       21
<PAGE>


     Acceleration   of   Options.   In  the  event  of  any  of  the   following
stockholder-approved  transactions to which the Company is a party (a "Corporate
Transaction"):

          (i)  a merger or  consolidation  in which the Company is not
               the  surviving  entity,  except for a  transaction  the
               principal  purpose  of which is to change  the state of
               the Company's incorporation; 

          (ii) the  sale,  transfer  or  other  disposition  of all or
               substantially  all of the  assets  of  the  Company  or
                complete liquidation or dissolution of the Company; or

          (iii)a reverse  merger in which the Company is the surviving
               entity but in which securities possessing more than 50%
               of the total  combined  voting  power of the  Company's
               outstanding  securities are  transferred to a person or
               persons  different from those who held such  securities
               immediately prior to such merger;

           each outstanding  option will  automatically  accelerate so that each
option will,  immediately prior to the specified  effective date for a Corporate
Transaction,  become  exercisable for the total number of shares of Common Stock
at that time subject to such option and may be exercised  for all or any portion
of such shares as fully-vested  shares.  However, an outstanding option will not
so  accelerate  if and to the  extent:  (1) the  option is to be  assumed by the
successor  corporation (or its parent corporation) in such Corporate Transaction
or (2) the acceleration of such option is subject to other  limitations  imposed
by the Plan Administrator at the time of grant.

      Immediately  following the  consummation of a Corporate  Transaction,  all
outstanding  options  under  the  1992  Plan  will  terminate  and  cease  to be
exercisable, except to the extent assumed by the successor corporation.

      The Company's outstanding  repurchase rights under the 1992 Plan will also
terminate,  and the shares subject to such  repurchase  rights will become fully
vested,  upon a Corporate  Transaction,  except to the extent (i) one or more of
such repurchase  rights are to be assigned to the successor  corporation (or its
parent  company)  or  (ii)  such  accelerated  vesting  is  precluded  by  other
limitations  imposed by the Plan Administrator at the time the repurchase rights
are issued.

      The Plan  Administrator  will have full power and  authority,  exercisable
either at the time the option is granted or at any time while the option remains
outstanding,   to  provide  for  the  automatic  acceleration  of  one  or  more
outstanding options under the Discretionary Option Grant Program in the event of
a Change  in  Control  (as  described  below) so that  each  such  option  will,
immediately  prior to such Change in  Control,  become  exercisable  for all the
shares of Common  Stock at that time subject to that option and may be exercised
for all or any  portion  of  those  shares  as  fully-vested  shares.  The  Plan
Administrator  will also have complete  discretion in establishing  the specific
terms  and  conditions  upon  which  one or  more of the  Company's  outstanding
repurchase  rights  under the 1992 Plan are to terminate  in  connection  with a
Change in Control.

      For all purposes under the 1992 Plan, a "Change in Control" will be deemed
to occur if:

          (i)  any person or related group of persons  (other than the
               Company  or  a  person  that   directly  or  indirectly
               controls,  is controlled by, or is under common control
               with,  the  Company)  directly or  indirectly  acquires
               beneficial  ownership (within the meaning of Rule 13d-3
               of the Securities  Exchange Act of 1934, as amended) of
               securities  possessing  more  than  50%  of  the  total
               combined  voting  power  of the  Company's  outstanding
               securities  pursuant to a tender or exchange offer made
               directly to the Company's stockholders; or

          (ii) the  composition  of the Board changes over a period of
               24  consecutive  months or less such that a majority of
               the  Board  members  cease,  by  reason  of one or more
               contested   elections  for  Board  membership,   to  be
               comprised of individuals who either (A) have been Board
               members continuously since the beginning of such period
               or (B) have been elected or  nominated  for election as
               Board members during such period by at least a majority
               of the Board  members  described in clause (A) who were
               still in office at the time such election or nomination
               was approved by the Board.


                                       22
<PAGE>

      Upon a Change in Control,  all outstanding options will remain exercisable
until the  expiration or sooner  termination of the option term specified in the
instrument evidencing the option.

      The  acceleration  of options in the event of a Corporate  Transaction  or
Change in Control  may be seen as an  anti-takeover  provision  and may have the
effect of discouraging a merger proposal, a takeover attempt or other efforts to
gain control of the Company.

      Cancellation  and  Regrant  of  Options.  The Plan  Administrator  has the
authority to effect the cancellation of any or all options outstanding under the
1992 Plan and to grant in substitution therefor new options covering the same or
different numbers of shares of Common Stock but with an exercise price per share
based upon the fair market value of the Common Stock on the new grant date.

      Please  note  that  the  share   numbers  and  exercise   prices  in  this
"Cancellation and Regrant of Options" section DO NOT reflect the approval of the
proposed Reverse Stock Split or filing of the Reverse Stock Split Amendment, and
are therefore  not reflected on a  post-Reverse  Stock Split basis.  

      On  September  18,  1998,  the Plan  Administrator  implemented  an option
cancellation/regrant  program for all  employees of the Company,  including  the
Company's executive officers.  Pursuant to that program,  each such employee was
given the opportunity to surrender his or her outstanding options under the 1992
Plan with  exercise  prices in  excess of $1.281  per share in return  for a new
option grant for the same number of shares but with an exercise  price of $1.281
per share,  the closing  selling  price per share of Common Stock as reported on
the  Nasdaq  National  Market on the  September  18,  1998 grant date of the new
option. Options for a total of 1,855,205 shares with a weighted average exercise
price of $5.2745 per share were  surrendered for  cancellation,  and new options
for the same number of shares were  granted  with the $1.281 per share  exercise
price.  To the extent the  higher-priced  option was  exercisable for any option
shares on the September 18, 1998  cancellation  date,  the new option granted in
replacement of that option will become  exercisable for those shares in a series
of 12 successive equal monthly  installments  upon the optionee's  completion of
each month of service over the one-year  period  measured from the September 18,
1998 grant date.  The option will become  exercisable  for the remaining  option
shares in one or more  installments  over the  optionee's  period  of  continued
service,  with each such  installment to vest on the same vesting date in effect
for that installment under the cancelled higher-priced option.

      On  October  20,  1998,  the  Plan  Administrator  implemented  an  option
cancellation/regrant  program for the non-employee Board members and certain key
consultants  holding  options under the Plan.  Pursuant to the October  program,
each  such  individual  was  given  the  opportunity  to  surrender  his  or her
outstanding options under the Plan with exercise prices in excess of $1.4375 per
share in return for a new option grant for the same number of shares but with an
exercise  price of $1.4375  per share,  the closing  selling  price per share of
Common Stock as reported on the Nasdaq  National  Market on the October 20, 1998
grant  date of the new  option.  Options  for a total of 584,639  shares  with a
weighted  average  exercise  price of  $6.1233  per share were  surrendered  for
cancellation,  and new options for the same number of shares were  granted  with
the $1.4375 per share exercise price. To the extent the higher-priced option was
exercisable for any option shares on the October 20, 1998 cancellation date, the
new option  granted in replacement  of that option will become  exercisable  for
those shares in a series of 12 successive  equal monthly  installments  upon the
optionee's completion of each month of service over the one-year period measured
from the October 20, 1998 grant date. The option will become exercisable for the
remaining option shares in one or more  installments  over the optionee's period
of continued  service,  with each such  installment  to vest on the same vesting
date in effect for that installment under the cancelled higher-priced option.

      Stock  Appreciation  Rights. The Plan Administrator is authorized to issue
two types of stock  appreciation  rights in  connection  with option grants made
under the Discretionary Option Grant Program:

           Tandem stock  appreciation  rights  provide the holders with
      the  right  to  surrender   their  options  for  an  appreciation
      distribution  from the  Company  equal in amount to the excess of
      (a) the fair market  value of the vested  shares of Common  Stock
      subject to the surrendered option over (b) the aggregate exercise
      price  payable for such shares.  Such  appreciation  distribution
      may, at the discretion of the Plan Administrator, be made in cash
      or in shares of Common Stock.


                                       23
<PAGE>

           Limited stock appreciation  rights may be provided to one or
      more officers of the Company as part of their option grants.  Any
      option  with  such  a  limited  stock   appreciation  right  will
      automatically  be cancelled upon the  successful  completion of a
      hostile   tender  offer  for  more  than  50%  of  the  Company's
      outstanding  voting  securities.  In  return  for  the  cancelled
      option,  the officer will be entitled to a cash distribution from
      the Company in an amount per cancelled  option share equal to the
      excess of (a) the highest price per share of Common Stock paid in
      connection  with the  tender  offer over (b) the  exercise  price
      payable for such share.

      Outstanding stock  appreciation  rights granted before January 26, 1993 to
certain  officers and  directors of the Company under the  Predecessor  Plan and
incorporated  into the  1992  Plan  allow  such  individuals  to  surrender  the
underlying  options to the Company for a cash  distribution,  calculated  in the
manner  indicated  above, in the event a hostile tender offer for 50% or more of
the  Company's  outstanding  voting  securities is  successfully  completed or a
change in the majority of the Board of Directors is effected through one or more
proxy contests.

Automatic Option Grant

      If this Proposal is approved by the  stockholders,  the following  changes
will be made to the Automatic  Option Grant Program for the  non-employee  Board
members:
    
           (i) The existing provisions of the program pursuant to which
      the non-employee Board members receive an annual option grant, on
      the date of each Annual Stockholders  Meeting, for that number of
      shares of Common  Stock  determined  by  dividing  $50,000 by the
      average  closing  selling  price of the  Common  Stock for the 30
      trading  days  immediately  preceding  the  date of  such  Annual
      Meeting,  but in no event  will the  number  of  shares of Common
      Stock  subject  to such  grant be more than 375  shares nor fewer
      than 250 shares will be  eliminated,  and no such  annual  option
      grants will be made at the 1999 Annual Meeting.

           (ii) A  special  one-time  option  grant  will  be  made  on
      February  1, 2000 to each  individual  serving as a  non-employee
      Board  member at that  time.  The  option  will  allow  each such
      non-employee  Board  member to purchase  that number of shares of
      Common  Stock  equal to one  half of one  percent  (0.5%)  of the
      number  of  voting   shares  of  the   Company's   capital  stock
      outstanding at that time.

           (iii)Each   individual  who  first  joins  the  Board  as  a
      non-employee   Board  member  will,   upon  his  or  her  initial
      appointment or election to the Board,  receive a special one-time
      option  grant for that number of shares of Common  Stock equal to
      one half of one percent  (0.5%) of the number of voting shares of
      the  Company's  capital  stock  outstanding  on February 1, 2000,
      provided such  individual has not  previously  been the Company's
      employ.  Such grant will be lieu of the 1,000-share  option grant
      currently  provided  under the  program  for  newly-appointed  or
      elected non-employee Board members, and the number of shares sub-
      ject to such adjusted for any, subsequent changes in the Company's 
      capital structure resulting from stock dividends, stock splits, or
      other similiar transactions.

     Stockholder approval of this Proposal Six will also constitute pre-approval
of each option granted on or after the date of this Annual  Meeting  pursuant to
the provisions of the Automatic Option Grant Program summarized in this Proposal
and the subsequent exercise of that option in accordance with those provisions.

      The option exercise price per share for each automatic grant will be equal
to the fair market value per share of Common Stock on the grant date and will be
payable in cash or shares of Common  Stock.  The options  may also be  exercised
through a same-day sale program,  pursuant to which a designated  brokerage firm
effects the  immediate  sale of the shares  purchased  under the option and pays
over to the Company,  out of the sale proceeds available on the settlement date,
sufficient funds to cover the exercise price for the purchased shares.

      Each  automatic option  grant will have a maximum  term of 10 years.  Each
automatic grant will become  exercisable for the option shares in a series of 48


                                       24
<PAGE>

successive equal monthly  installments  over the optionee's  period of continued
Board  service,  measured  from the grant date.  Prior  option  grants under the
program, all of which have been surrendered, vested in a series of 24 successive
equal  monthly  installments  measured  from the  applicable  grant  date.  Each
outstanding  option under the revised Automatic Option Grant Program will become
immediately   exercisable  for  all  of  the  option  shares  upon  a  Corporate
Transaction  or Change in Control.  In addition,  each such option grant will be
automatically cancelled upon the successful completion of a hostile tender offer
for more than 50% of the Company's outstanding voting securities. In return, the
optionee will be entitled to a cash  distribution  from the Company in an amount
per  cancelled  option  share equal to the excess of (a) the  highest  price per
share of Common  Stock paid in  connection  with the  tender  offer over (b) the
exercise  price  payable for such share.  Stockholder  approval of this Proposal
Six  will  constitute  approval of each option  granted  with such an  automatic
cancellation  provision  on or after  the date of this  Annual  Meeting  and the
subsequent  cancellation of that option in accordance  with such  provision.  No
additional  approval of the Plan  Administrator or the Board will be required at
the time of the actual option cancellation and cash distribution.

      All automatic option grants held by the  non-employee  Board member at the
time of his or her  cessation  of Board  service will remain  exercisable  for a
period  of six  months  for  any or all  shares  for  which  those  options  are
exercisable at the time of such cessation of Board service.  However, should the
optionee die while holding one or more  options,  then those options will remain
exercisable for a 12-month period following the date of the optionee's death and
may be exercised,  for any or all shares for which those options are exercisable
at the time of the  optionee's  cessation  of  Board  service,  by the  personal
representative  of the  optionee's  estate or by the persons to whom the options
are  transferred by the  optionee's  will or by the laws of  inheritance.  In no
event may any such option be exercised  after the expiration date of the 10-year
option term.

General Provisions

      Amendment and  Termination of the 1992 Plan. The Board may amend or modify
the 1992 Plan in any or all respects whatsoever.  However, no such amendment may
adversely affect the rights of outstanding option holders without their consent.
In addition,  certain  amendments may require  stockholder  approval pursuant to
applicable law or regulation.

      The Board may terminate the 1992 Plan at any time,  and the 1992 Plan will
in all events terminate not later than December 31, 2002 or December 31, 2008 if
this Proposal Six  is approved. Any options outstanding at the time of such plan
termination  will continue to remain  outstanding  and exercisable in accordance
with the terms and provisions of the instruments  evidencing  those grants.  The
1992  Plan  will,  however,  automatically  terminate  on the  date  all  shares
available for issuance are issued as vested shares or cancelled  pursuant to the
exercise, surrender or cash-out of outstanding options under the 1992 Plan.

      Tax  Withholding.  The  Compensation  Committee may, in its discretion and
upon such terms and conditions as it may deem  appropriate,  provide one or more
option holders under the Discretionary Option Grant Program with the election to
have the Company  withhold,  from the shares of Common Stock otherwise  issuable
upon the exercise of their options,  a portion of those shares with an aggregate
fair market value equal to the designated percentage (up to 100% as specified by
the option holder) of the federal,  state and local withholding tax liability to
which such option holder may become  subject in connection  with the exercise of
such  option.  Any  election  so made will be  subject  to the  approval  of the
Compensation Committee,  and no shares will actually be withheld in satisfaction
of such taxes except to the extent approved by the Compensation  Committee.  One
or more option  holders may also be granted the  alternative  right,  subject to
Committee  approval,  to  deliver  previously-issued  shares of Common  Stock in
satisfaction of such tax liability.

      Changes in  Capitalization.  In the event any change is made to the Common
Stock issuable under the 1992 Plan by reason of any stock split, stock dividend,
recapitalization,  combination of shares, exchange of shares, or other change in
corporate  structure  effected without the Company's  receipt of  consideration,
appropriate  adjustments  will be made to (i) the maximum number and/or class of
securities  issuable  under  the 1992  Plan,  (ii) the  number  and/or  class of
securities and price per share in effect under each  outstanding  option,  (iii)
the maximum  number and/or class of securities  for which any one individual may
be granted stock options and separately  exercisable stock  appreciation  rights
under  the  1992  Plan  per  calendar  year,  (iv) the  number  and/or  class of
securities for which automatic option grants are subsequently to be made to each




                                       25
<PAGE>

newly-elected  non-employee Board member and (v) the maximum number and/or class
of  securities  by which the .share  reserve is to increase  each  calendar year
pursuant to the automatic share increase provisions of the 1992 Plan.

      Each  outstanding  option  which is assumed or is otherwise to continue in
effect after a Corporate Transaction will be appropriately adjusted to apply and
pertain to the number and class of securities  which would have been issued,  in
connection with such Corporate Transaction, to the holder of such option had the
option  been  exercised   immediately  prior  to  such  Corporate   Transaction.
Appropriate  adjustments  will also be made to the  exercise  price  payable per
share and to the  number  and class of  securities  subsequently  available  for
issuance under the 1992 Plan on both an aggregate and per participant basis.

      Option grants under the 1992 Plan will not affect the right of the Company
to adjust,  reclassify,  reorganize or otherwise  change its capital or business
structure or to merge, consolidate,  dissolve, liquidate or sell or transfer all
or any part of its business or assets.

      Excess  Grants.  The 1992 Plan  permits  the grant of options to  purchase
shares of Common  Stock in excess of the  number of shares  then  available  for
issuance under the 1992 Plan.  Any options so granted cannot be exercised  prior
to stockholder  approval of an amendment  sufficiently  increasing the number of
shares available for issuance under the 1992 Plan.

Option Grants

      The table below shows,  on a pre-Reverse  Stock Split basis, as to each of
the executive  officers  named in the Summary  Compensation  Table below and the
various  other  indicated  persons and groups,  the following  information  with
respect to stock option grants  effected  during the period from January 1, 1998
through  March 31,  1999:  (i) the number of shares of Common  Stock  subject to
options  granted  under the 1992 Plan during that period;  and (ii) the weighted
average  exercise  price  payable  per share under such  options.  The number of
shares and weighted  average  exercise  price  calculations  include all options
which were granted during the indicated  period and  subsequently  cancelled and
regranted at a lower  exercise  price per share on either  September 18, 1998 or
October 20, 1998. All share numbers and exercise  prices are reported on a basis
which does not reflect the proposed  Reverse  Stock Split.  

<TABLE>
<CAPTION>
                                         Options Granted       Weighted Average
         Name and Position              (Number of Shares)    Exercise Price ($)        
  ----------------------------------    ------------------    -----------------
<S>                                     <C>                   <C>
  Lisa A. Conte
  President, Chief Executive Officer
  and Chief Financial Officer                  2,045,000           $1.2810   
      
  Gerald M. Reaven,  M.D.
  Senior Vice  President, 
  Medical and Clinical Advisor                   215,000           $1.2810
       
  Atul S. Khandwala, Ph.D. (1)
  Former Senior Vice President,                 
  Development and Chief Regulatory 
  Officer                                         40,000           $1.4375
   
  Steven R. King, Ph.D.
  Senior Vice President,
  Ethnobotany and  Conservation                  148,810           $1.2810
       
  James S. Pennington, M.D. (2)       
  Former Senior Vice President, Clinical                
  Research and  Chief Medical Officer            125,000           $1.2810

  Laurie Peltier
  Vice President, Project Coordination            65,000           $1.2810
       
  All executive officers as a group            3,070,463           $1.3911      
  (11 persons)

  All directors who are not executive
  officers as a group (5 persons)                472,564           $1.6633
       
  All employees (88 persons) and
  consultants as a group, excluding                                               
  executive officers                             897,717           $1.7400

</TABLE>       
 ---------------------
       (1) The  Company  accepted  the  resignation  of  Dr.  Khandwala
       effective October 2, 1998.

       (2) Dr.  Pennington  was terminated  effective  February 19,1999
       due to the  elimination of his position in connection  with  the 
       Company's restructuring.


                                       26
<PAGE>

 
     The number of options  granted on either  September 18, 1998 or October 20,
1998 in  cancellation  of outstanding  higher-priced  options was as follows for
each of the indicated  individuals  and groups:  Ms. Conte,  options for 545,000
shares;  Dr. Reaven,  options for 215,000 shares;  Dr. Khandwala,  options for 0
shares;  Dr.  King,  options for 148,810  shares;  Dr.  Pennington,  options for
125,000, Ms. Peltier,  options for 55,000  shares;  all executive  officers as a
group,  1,278,810  shares;  all directors  who are not  executive  officers as a
group,  422,564  shares;  and all employees  (other than executive  officers and
directors) and consultants as a group, 738,470 shares.

      Effective as of April ___,  1999,  each member of the Board of  Directors,
including Ms. Conte has  surrendered  all of his or her  outstanding  options to
purchase shares of the Company's Common Stock.

      On November 7, 1998,  the Company issued 747,206 shares of Common Stock in
the aggregate to certain  individuals in connection with the consulting services
they  rendered the Company.  None of the shares were issued under the 1992 Plan.
However, certain individuals eligible to participate in the 1992 Plan received a
portion of the issued shares. G. Kirk Raab,  Chairman of the Board of Directors,
was issued  135,652  shares of Common Stock and Atul S.  Khandwala,  Ph.D.,  the
Company's  former  Senior  Vice  President,  Development  and  Chief  Regulatory
Officer, was issued 87,326 shares of Common Stock.

Federal Tax Consequences

      Options granted under the 1992 Plan may be either  incentive stock options
which satisfy the  requirements  of Section 422 of the Internal  Revenue Code or
non-statutory  options  which are not  intended to meet such  requirements.  The
federal  income tax treatment for the two types of options  differs as described
below.

      Incentive Options.  No taxable income is recognized by the optionee at the
time of the option grant,  and no taxable income is generally  recognized at the
time the option is exercised.  However,  the difference  between the fair market
value of the purchased  shares and the exercise  price is generally  included as
alternative  minimum taxable income for purposes of the alternative minimum tax.
The optionee will  recognize  taxable  income in the year in which the purchased
shares are sold or otherwise  made the subject of  disposition.  For federal tax
purposes,  dispositions are divided into two categories: (i) qualifying and (ii)
disqualifying.  The optionee will make a qualifying disposition of the purchased
shares  if the  sale or other  disposition  of such  shares  is made  after  the
optionee has held the shares for more than two years after the grant date of the
option and more than one year after the exercise  date. If the optionee fails to
satisfy either of these two minimum  holding  periods prior to the sale or other
disposition  of the purchased  shares,  then a  disqualifying  disposition  will
result.

      Upon a qualifying  disposition of the shares,  the optionee will recognize
long-term  capital  gain in an  amount  equal to the  excess  of (i) the  amount
realized upon the sale or other  disposition  of the purchased  shares over (ii)
the exercise price paid for such shares. If there is a disqualifying disposition
of the shares,  then the excess of (a) the fair market  value of those shares on
the  exercise  date over (b) the  exercise  price  paid for the  shares  will be
taxable as ordinary income.  Any additional gain recognized upon the disposition
will be a capital gain.

      If the optionee makes a disqualifying disposition of the purchased shares,
then the Company  will be entitled to an income tax  deduction,  for the taxable
year in which  such  disposition  occurs,  equal to the  excess  of (i) the fair
market  value of such shares on the exercise  date over (ii) the exercise  price
paid for the  shares.  In no  other  instance  will the  Company  be  allowed  a
deduction with respect to the optionee's disposition of the purchased shares.

      Non-Statutory Options. No taxable income is recognized by an optionee upon
the grant of a  non-statutory  option.  The optionee  will in general  recognize
ordinary  income,  in the year in which the  option is  exercised,  equal to the
excess of the fair market value of the  purchased  shares on the  exercise  date
over the exercise  price paid for the shares,  and the optionee will be required
to satisfy the tax withholding requirements applicable to such income.

       Special  provisions of the Internal Revenue Code apply to the acquisition
of unvested shares of Common Stock under a non-statutory  option.  These special
provisions may be summarized as follows:




                                       27
<PAGE>

            (i)  If  the   shares   acquired   upon   exercise   of  the
       non-statutory  option are subject to repurchase by the Company at
       the  original  exercise  price  in the  event  of the  optionee's
       termination of service prior to vesting in such shares,  then the
       optionee  will not  recognize  any taxable  income at the time of
       exercise but will have to report as ordinary income,  as and when
       the Company's  repurchase  right  lapses,  an amount equal to the
       excess of (a) the fair market value of the shares on the date the
       Company's  repurchase  right  lapses with respect to those shares
       over (b) the exercise price paid for the shares.

            (ii) The optionee may, however, elect under Section 83(b) of
       the Internal  Revenue  Code to include as ordinary  income in the
       year of exercise of the  non-statutory  option an amount equal to
       the excess of (a) the fair market value of the  purchased  shares
       on the  exercise  date  (determined  as if the  shares  were  not
       subject to the Company's  repurchase right) over (b) the exercise
       price paid for such  shares.  If the  Section  83(b)  election is
       made,  the optionee will not recognize any  additional  income as
       and when the Company's repurchase right lapses.

      The Company will be entitled to a business expense  deduction equal to the
amount of  ordinary  income  recognized  by the  optionee  with  respect  to the
exercised non-statutory option. The deduction will in general be allowed for the
taxable year of the Company in which such  ordinary  income is recognized by the
optionee.

      Deductibility of Executive Compensation.  The Company anticipates that any
compensation deemed paid by it in connection with disqualifying  dispositions of
incentive stock option shares or exercises of non-statutory options granted with
an  exercise  price  equal to the fair  market  value of the option  shares will
qualify as  performance-based  compensation  for purposes of Code Section 162(m)
and will not  have to be taken  into  account  for  purposes  of the $1  million
limitation per covered  individual on the deductibility of the compensation paid
to certain executive officers of the Company.

      Stock Appreciation Rights. An optionee who is granted a stock appreciation
right will recognize ordinary income in the year of exercise equal to the amount
of the  appreciation  distribution.  The Company  will be entitled to a business
expense deduction equal to the appreciation distribution for the taxable year of
the Company in which the ordinary income is recognized by the optionee.

      Parachute   Payments.   If  the  exercisability  of  an  option  or  stock
appreciation  right is accelerated as a result of a change of control,  all or a
portion of the value of the option or stock  appreciation right at that time may
be a parachute  payment for purposes of the excess  parachute  provisions of the
Internal  Revenue Code.  Those  provisions  generally  provide that if parachute
payments equal or exceed three times an employee's average  compensation for the
five tax years preceding the change of control,  the Company loses its deduction
and the recipient is subject to a 20% excise tax for the amount of the parachute
payments in excess of one times such average compensation.

      Note  Forgiveness.  If any promissory  note delivered in payment of shares
acquired under the 1992 Plan is forgiven in whole or in part, the amount of such
forgiveness  will be  reportable  by the  participant  as ordinary  compensation
income.  The Company will be entitled to a business  expense  deduction equal to
the amount of ordinary  income  recognized by the participant in connection with
the  acquisition of the shares and any note  forgiveness.  The deduction will be
allowed for the  taxable  year of the  Company in which the  ordinary  income is
recognized by the participant.

Accounting Treatment

      Option grants or stock  issuances to employees and members of the Board of
Directors  with  exercise or issue prices less than the fair market value of the
shares on the grant or issue  date will  result in  compensation  expense to the
Company's earnings equal to the excess of the fair market value of the shares on
the grant or issue date over the  exercise or issue  price.  Such charge will be
expensed by the Company over the period benefited (usually the vesting period of
the option).  Option grants or stock issuances with exercise or issue prices not
less than the fair  market  value of the  shares on the grant or issue date will
not result in any direct charge to the  Company's  earnings.  However,  the fair
value of those options is required to be disclosed in the notes to the Company's
financial  statements,   and  the  Company  must  also  disclose,  in  pro-forma
disclosures  in the  Company's  financial  statements,  the impact those options



                                       28
<PAGE>

would have upon the Company's  reported earnings were the value of those options
at the time of grant treated as compensation expense.  Whether or not granted at
a discount, the number of outstanding options may be a factor in determining the
Company's earnings per share on a fully-diluted basis.

      The Financial  Accounting Standards Board recently announced its intention
to issue an  exposure  draft of a proposed  interpretation  of APB  Opinion  25,
"Accounting for Stock Issued to Employees."  Under the proposed  interpretation,
option grants made to  non-employee  Board members after  December 15, 1998 will
result in a direct charge to the Company's reported earnings based upon the fair
value  of  the  option  measured  initially  as  of  the  grant  date  and  then
subsequently  on the  vesting  date of each  installment  of the option  shares.
Accordingly,  such charge  will  include  the  appreciation  in the value of the
option  shares  over the period  between  the grant date of the option  (or,  if
later, the effective date of the final  interpretation ) and the vesting date of
each   installment  of  the  option  shares.   In  addition,   if  the  proposed
interpretation  is adopted,  any options which are repriced  after  December 15,
1998 will also trigger a direct charge to Company's  reported  earnings measured
by the  appreciation  in the  value of the  underlying  shares  over the  period
between the grant date of the option (or, if later,  the  effective  date of the
final interpretation) and the date the option is exercised for those shares. The
accounting is the same as is currently  applied for option grants to independent
consultant.

      Should one or more  optionees be granted stock  appreciation  rights which
have no  conditions  upon  exercisability  other  than a service  or  employment
requirement,  then such rights will result in compensation expense to be charged
against the Company's earnings.  Accordingly, at the end of each fiscal quarter,
the amount (if any) by which the fair market value of the shares of common stock
subject to such outstanding stock  appreciation  rights has increased from prior
quarter-end  will be accrued as  compensation  expense,  to the extent such fair
market  value is in excess of the  aggregate  exercise  price in effect for such
rights.

New Plan Benefits

      No stock  option grants have been made to date under the Plan on the basis
of the amendments for which  stockholder  approval is sought under this Proposal
Six.  However, if such stockholder approval is obtained, the on February 1, 2000
each of the  non-employee  Board members will receive an automatic  option grant
for that  number  of shares of  Common  Stock  equal to one half of one  percent
(0.5%) of the number of voting shares of the Company's capital stock outstanding
at that time.  Each such option  will have an exercise  price per share equal to
the fair market value per share of Common Stock on that date.

Stockholder Vote

      The  affirmative  vote  of the  holders  of a  majority  of the  Company's
outstanding voting shares, present or represented by Proxy at the Annual Meeting
and entitled to vote is required for approval of this Proposal Six.


Recommendation of the Board of Directors

      The  Board of  Directors  recommends  that the  stockholders  vote FOR the
approval of the amendment to the 1992 Plan as described in this  Proposal  Six.
If such  stockholder  approval is not obtained,  then any options granted on the
basis of the proposed  share  increases  which form part of such  Proposal  will
terminate  without  becoming  exercisable  for any of the shares of Common Stock
subject to those options, and no further option grants will be made on the basis
of such increases.  In addition,  the special one-time option grants proposed to
be made to the non-employee  Board members on February 1, 2000 will not be made.
However,  in the  absence  of such  stockholder  approval,  the 1992  Plan  will
continue to remain in effect, and option grants may continue to be made pursuant
to the provisions of the 1992 Plan in effect prior to the amendments  summarized
in this  Proposal  Six,  until the  available  reserve of Common  Stock as last
approved by the stockholders has been issued.  Because the shares subject to the
1992 Plan are subject to the 20 to 1 Reverse  Stock Split in Proposal  Two,  the
shares  reserved  for future  issuance  under the 1992 Plan are  expected  to be
exhausted very quickly.  Additionally,  those Board Members who have voluntarily
surrendered their options would not receive any further  compensation  under the
1992 Plan.



                                       29
<PAGE>

      The  Board believes  that the  proposed  amendments  to the 1992  Plan are
essential to the Company's  efforts in attracting  and retaining the services of
highly qualified  individuals who can contribute  significantly to the Company's
business and  financial  success.  Without  access to such option  pool,  it may
require substantially more cash to attract and retain such individuals,  if such
attraction and retention is even  possible.  Accordingly,  the Board  recommends
that the  stockholders  vote IN FAVOR OF approval of the  amendments to the 1992
Plan.




                                       30
<PAGE>




                                 PROPOSAL SEVEN

                      RATIFICATION OF INDEPENDENT AUDITORS


      Upon the  recommendation  of the Audit Committee,  the Board has appointed
the firm of Ernst & Young  LLP,  independent  auditors,  to audit the  financial
statements of the Company for the year ending  December 31, 1999,  and is asking
the stockholders to ratify this appointment.

      In the event the stockholders  fail to ratify the  appointment,  the Board
will reconsider its selection.  Even if the selection is ratified,  the Board in
its discretion may direct the  appointment of a different  independent  auditing
firm at any time during the year if the Board feels that such a change  would be
in the best interests of the Company and its stockholders.  The affirmative vote
of the holders of a majority of the Company's outstanding voting shares, present
or  represented  by Proxy at the Annual Meeting and entitled to vote is required
to ratify the selection of Ernst & Young LLP.

      Ernst & Young LLP has audited the Company's financial  statements annually
since  November  1992. A  representative  of Ernst & Young LLP is expected to be
present at the Annual Meeting to respond to appropriate  questions,  and will be
given the opportunity to make a statement if he or she so desires.

Recommendation of the Board of Directors

      The  Board  recommends  that  the  stockholders   vote  IN  FAVOR  OF  the
ratification  of the  selection  of Ernst & Young LLP to serve as the  Company's
independent auditors for the year ending December 31, 1999.





                                       31
<PAGE>




                  EXECUTIVE COMPENSATION AND OTHER INFORMATION


      Certain information about the Company's  executive  officers,  as of March
31, 1999, is set forth below.  Information  concerning  the Class I and Class II
directors,  including Lisa A. Conte,  the Company's  President,  Chief Executive
Officer and Chief Financial  Officer is contained in "Proposal One - Election of
Directors."


<TABLE>
<CAPTION>
         Name                 Age                   Position
- -------------------------     ---    -------------------------------------------
<S>                           <C>     <C>                                    
Steven R. King, Ph.D.....     41     Senior Vice President, Ethnobotany and
                                     Conservation                                     

Gerald M. Reaven, M.D....     70     Senior Vice President, Medical and Clinical
                                     Advisor                                   

Thomas Carlson, M.D......     42     Vice President, Medical Ethnobotany                                    

John W.S. Chow, Ph.D.....     47     Vice President, Technical Operations                                     

J.D. Haldeman............     34     Vice President, Commercial Development                                     

Laurie Peltier ..........     47     Vice President, Project Coordination
                                     
</TABLE>

     Steven R. King,  Ph.D.  joined Shaman in March 1990. He currently serves as
Senior Vice  President,  Ethnobotany  and  Conservation  and is responsible  for
coordinating the Company's Scientific Strategy Team. From 1989 to 1990, Dr. King
was the chief  botanist  for  Latin  America  at  Arlington,  Virginia's  Nature
Conservancy.  He worked  in 1988 as  Research  Associate  for the  Committee  on
Managing Global Genetic Resources at the National Academy of Sciences, and was a
Doctoral Fellow from 1983 to 1988 at The New York Botanical  Garden's  Institute
of Economic  Botany.  Dr. King received a B.A. in Human Ecology from the College
of the Atlantic and M.S. and Ph.D.  degrees in Biology from City  University  of
New York.

     Gerald M. Reaven,  M.D.  joined Shaman as a consultant in February 1995 and
became an employee in July 1995. He currently  serves as Senior Vice  President,
Medical and  Clinical  Advisor.  Dr.  Reaven  came to Shaman  from the  Stanford
University School of Medicine where he served as a faculty member since 1960 and
a Professor of Medicine since 1970. Over the last 20 years, Dr. Reaven served as
head of the  Division  of  Endocrinology  and  Metabolic  Diseases,  Division of
Gerontology and director of the General  Clinical  Research  Center.  Dr. Reaven
also served as head of the Division of Endocrinology, Gerontology and Metabolism
at  Stanford  University  School of  Medicine,  and  Director  of the  Geriatric
Research,  Education  and Clinical  Center,  at the Palo Alto  Veterans  Affairs
Medical Center.  Dr. Reaven received his A.B., B.S. and M.D. from the University
of Chicago.

     Thomas  Carlson,  M.D.  joined Shaman in October 1992. He currently  serves
Vice   President,   Medical   Ethnobotany  and  is  responsible  for  developing
ethnobotancial field research and coordinating clinical studies. Dr. Carlson has
conducted research with traditional healers in over 40 different ethnolinguistic
groups in 15 different tropical countries. Prior to joining Shaman, from 1990 to
1992, Dr. Carlson  practiced  General  Pediatrics at Kaiser  Permanente in Santa
Clara,  California  and worked at the Aravind  Childrens  and Eye  Hospitals  in
Madurai,  India on child  malnutrition  and  blindness.  From 1987 to 1990,  Dr.
Carlson  completed  his  Internship  and  Residence  in  Pediatrics  at Stanford
University  Medical  Center.  Dr. Carlson  received his M.D. from Michigan State
University and a B.S. and M.S. in Botany from the University of Michigan.

     John W.S.  Chow,  Ph.D.  joined  Shaman in April 1998 as Vice  President of
Technical Operations.  Prior to joining the Company, from December 1997 to April
1998,  Dr.  Chow  served as  Director,  Product  and  Technology  Evaluation  at
Bristol-Myers Squibb Company,  where he performed technical due diligence toward
the  acquisition  and  licensing of various  dosage forms and  technologies  and
reviewed  and  approved  new  product  specifications.  Prior  to  holding  this
position,  from July 1980 to December 1997, Dr. Chow held other positions,  also
with  Bristol-Myers  Squibb  Company,  where he was  responsible  for developing
strategies for manufacturing consolidation, facilitating technology transfers of
new  and  existing   products,   and  directing   technical   operations  of  an
international  plant. Dr. Chow received a B.S. in Pharmacy from Washington State
University,  a Ph.D. in 



                                       32
<PAGE>

Pharmaceutical  Chemistry  from  Ohio  State  University  and  an   M.B.A.   in 
Pharmaceutical/Chemical   Studies  from  Fairleigh   Dickinson University.

     J.D.  Haldeman  joined  Shaman in July 1997 as Vice  President,  Commercial
Development.  Prior to joining the  Company,  from April 1988 to June 1997,  Ms.
Haldeman   served   in   various    positions   at    Warner-Lambert/Parke-Davis
Pharmaceuticals   ("Warner-Lambert"),   most   recently   as  Senior   Director,
Cardiovascular  Marketing  from  October 1995 to June 1997.  Prior to that,  she
served as Director,  Customer  Marketing--West  Customer Business Unit;  Product
Manager, Epilepsy Team; Associate Product Manager, Global Cardiovascular Product
Planning;  and Sales Specialist for  Warner-Lambert.  Ms. Haldeman  received her
B.A. from Brigham Young  University and her Masters of Management  from the J.L.
Kellogg Graduate School of Management, Northwestern University.

     Laurie  Peltier  joined  Shaman  in June  1997 as Vice  President,  Project
Coordination.  Prior to joining  the  Company,  from June 1992 to May 1997,  Ms.
Peltier served as Senior Director, Project Management at Amylin Pharmaceuticals,
Inc.  Prior  to  that,   she  served  as  Director,   Development  at  Quintiles
Transnational  Corp.,  a contract  research  organization,  from May 1990 to May
1992. Ms. Peltier served in various positions in biostatics  clinical operations
at Syntex  Corporation  from May 1979 through April 1990. Ms. Peltier received a
B.S. in Psychology from the University of Michigan, Flint, an M.A. in Psychology
and an M.S. in Statistics from Northern  Illinois  University and an M.B.A. from
Golden Gate University.

Compensation Committee Interlocks and Insider Participation

      During the 1998 fiscal  year,  Herbert H.  McDade and Adrian D.P.  Bellamy
served as members of the  Compensation  Committee of the Board of Directors.  No
member of the  Compensation  Committee  was,  at any time during the 1998 fiscal
year or at any earlier time, an officer or employee of the Company.

      No  executive  officer of the  Company  serves as a member of the board of
directors  or  compensation  committee  of any  entity  which  has  one or  more
executive  officers  serving as a member of the Company's  Board of Directors or
Compensation Committee.

Compensation Committee Report on Executive Compensation

      As members of the  Compensation  Committee of the Board, it is our duty to
exercise the power and  authority of the Board of Directors  with respect to the
compensation  levels to be in effect for the Company's  executive  officers.  As
such,  it is our  responsibility  to set the base  salary of  certain  executive
officers and to administer  the 1992 Plan under which grants may be made to such
officers and other key employees.  In addition, we approved special bonus awards
for executive officers for the 1998 fiscal year.

      For 1998,  we  established  the  compensation  payable  to Lisa A.  Conte,
President,  Chief Executive Officer and Chief Financial  Officer,  the Company's
highest-paid  executive  officer,  and the Company's four other most highly-paid
executive officers. Ms. Conte reported to us the performance evaluations of each
executive  officer,  including  herself,  and the  factors to be  considered  in
setting their compensation. We endorse those factors and include them as part of
our report.

      General  Compensation  Policy.  Under our  supervision,  the  Company  has
developed a compensation policy that is designed to attract and retain qualified
key executives  critical to the Company's success and to provide such executives
with  performance-based  incentives  tied  to  corporate  milestones.  It is our
objective  to  have  a  substantial  portion  of  each  officer's   compensation
contingent  upon the  Company's  performance  as well as upon  the  individual's
contribution to the success of the Company as measured by personal  performance.
Accordingly, each executive officer's compensation package is normally comprised
of three elements: (i) base salary, which reflects individual performance and is
commensurate  with  salaries for  comparable  positions  in other  biotechnology
companies  given the level of seniority  and skills  possessed by such  officer,
(ii) long-term,  stock-based incentive awards, which strengthen the mutuality of
interests  between the  executive  officers and the Company's  stockholders  and
which may be tied to the Company's achievement of certain pre-established goals,
and (iii) bonus incentive plan, which tie to individual and Company performance.



                                       33
<PAGE>

      Guidelines.  Because the Company is in the  pre-product  commercialization
stage, the use of traditional  performance  standards (such as profitability and
return on  equity) is not  appropriate  in  evaluating  the  performance  of its
executive  officers.  In  particular,  the  unique  nature of the  biotechnology
industry,  the relatively  short period of time during which the Company's stock
has been publicly traded,  the performance of the stock during this period,  and
the  absence of product  revenues  have made it  impossible  to tie  performance
objectives to standard financial considerations. The primary guidelines which we
did  consider  in  establishing  the  components  of  each  executive  officer's
compensation  package  for 1998 are  summarized  below.  However,  we may in our
discretion apply entirely different guidelines,  particularly different measures
of performance, in setting executive compensation for future fiscal years.

      Base  Salary.   Base   compensation  is  initially   established   through
negotiation  between the Company and the  executive at the time the executive is
hired,  and it is subject to periodic review or  reconsideration,  usually on an
annual basis.  When establishing or reviewing the level of base compensation for
each  executive   officer,   we  consider   numerous   factors,   including  the
qualifications  of the  executive  and his or her level of relevant  experience,
strategic   goals  for  which  the   executive  has   responsibility,   specific
accomplishments   of  the  executive   during  the  last  fiscal  year  and  the
compensation  levels in effect at  companies  in the  Company's  industry  which
compete with the Company for business and executive talent.

      For comparative  compensation  purposes,  we have selected a peer group of
companies  within the industry  and  estimated  the salary  levels in effect for
similar  positions at those companies.  We also relied on specific  compensation
surveys,  making our decisions as to the appropriate market level of base salary
for each  executive  officer  on the basis of our  understanding  of the  salary
levels in effect for  similar  positions  at various  peer group  companies.  In
selecting  the peer group  companies,  we  focused  primarily  on whether  those
companies  were  actually  competitive  with the  Company in  seeking  executive
talent,  whether those  companies had a management  style and corporate  culture
similar to the  Company's and whether  similar  positions  existed  within their
corporate  structure.  For this reason,  there is not a  meaningful  correlation
between the peer group companies surveyed for comparative  compensation purposes
and the companies  included in the Hambrecht & Quist  Biotechnology  Index which
the Company has chosen as the industry  index for purposes of the Company  Stock
Price Performance graph which follows this report.

      Base salaries are reviewed  annually,  and  adjustments  to each executive
officer's  base  salary are made to reflect  individual  performance  and salary
increases effected by the peer group companies. A major objective,  accordingly,
is to have base salary levels  commensurate  with those of comparable  positions
with the peer group companies, given the level of seniority and skills possessed
by the  executive  officer in question and our  assessment  of such  executive's
performance over the year.

      We estimate (on the basis of 1998 surveys of executive  compensation) that
the base salary  levels in effect for the Company's  executive  officers for the
1998 fiscal year ranged from the 15th percentile to the 100th  percentile of the
base salary levels in effect for executive officers in comparable positions with
peer group companies.

     Incentive  Compensation.  The  Committee  did not  award any  speical  cash
bonuses  to the  executive  officers  for the 1998  fiscal  year.  However,  all
employees,  including executive officers,  were each awarded a $3,000 cash bonus
during the 1998  fiscal  year based upon the  Company's  achievement  of certain
milestones during the 1997 fiscal year.

      Stock-Based  Incentive  Compensation.  In  addition  to  establishing  and
reviewing the base salary levels in effect for the executive  officers,  we also
have  discretionary  authority to award equity  incentives  in the form of stock
option  grants to the  executive  officers  as a way to more  closely  align the
interests of management with those of the Company's  stockholders  and to reward
officers  for  achieving  certain  defined  personal and  corporate  performance
targets.  Factors which we consider in determining  whether to grant options and
the number of shares underlying each such grant include the executive's position
in the Company, his or her performance and responsibilities, the extent to which
he or she  already  holds an  equity  interest  in the  Company  and the  equity
incentives  granted  to  employees  with  similar   responsibilities   at  other
biotechnology  companies.  We  have  also  established  general  guidelines  for
maintaining the unvested option holdings of each executive officer at a targeted
level based upon his or her  position  with the Company,  and option  grants are
periodically made to maintain the targeted levels.  These factors,  however, are
used only as  guidelines,  and the relative  weight given to each factor  varies
from individual to individual as we deem appropriate under the circumstances.



                                       34
<PAGE>

      For 1998,  we approved  total stock option  grants under the 1992 Plan for
4,420,244 shares.  Ten of the executive  officers of the Company received option
grants in fiscal 1998. Each grant allows the executive officer to acquire shares
of the  Company's  Common  Stock at a fixed price per share (the market price on
the grant  date) over a specified  period of time (up to 10 years).  The options
vest in  periodic  installments  over four  year  periods,  contingent  upon the
executive  officer's  continued  employment with the Company.  In all cases, the
options will provide a return to the executive officer only if he or she remains
with the  Company  and then only if the market  price of the  underlying  shares
appreciates over the option term.

Special Option Regrant Program

      During  the  1998  fiscal  year,  the  Compensation  Committee  felt  that
circumstances  had made it  necessary  for the  Company to  implement  an option
cancellation/regrant  program for all  employees of the Company,  including  the
executive  officers.  Accordingly,  on September 18, 1998, each of the employees
was given the opportunity to surrender his or her outstanding  options under the
1992 Plan with exercise prices in excess of $1.281 per share in return for a new
option  grant for the same number of shares but with a lower  exercise  price of
$1.281 per share,  the fair market value per share of the Company's Common Stock
on the regrant date. Each employee eligible for a new option grant was given the
choice of accepting that option with a new vesting  schedule in  cancellation of
his or her  higher-priced  option or rejecting  the new grant and  retaining the
higher-priced option with its original vesting schedule.

      The  Compensation  Committee  determined  that this program was  necessary
because equity incentives are a significant  component of the total compensation
package  of  each  key  Company  employee  and  play a  substantial  role in the
Company's  ability  to retain  the  services  of  individuals  essential  to the
Company's long-term financial success. The Compensation  Committee felt that the
Company's  ability  to retain key  employees  would be  significantly  impaired,
unless value were restored to their options in the form of regranted  options at
the current market price of the Company's  Common Stock.  However,  in order for
the regranted  options to serve their primary  purpose of assuring the continued
service of each optionee, a new vesting schedule was imposed with respect to the
option shares.  Accordingly,  to the extent the higher-priced  option was vested
and  exercisable  for any option shares on the  September 18, 1998  cancellation
date,  the new  option  granted  in  replacement  of  that  option  will  become
exercisable  for  those  shares  in a  series  of 12  successive  equal  monthly
installments  upon the  optionee's  completion of each month of service over the
one-year period measured from the September 18, 1998 grant date. The option will
become  exercisable for the unvested and  unexercisable  option shares in one or
more  installments over the optionee's  period of continued  service,  with each
such installment to vest on the same vesting date in effect for that installment
under the cancelled  higher-priced  option. As a result, each optionee will only
have the opportunity to acquire the option shares at the lower exercise price if
he or she remains in the Company's employ.

      As a result of the new vesting schedules imposed on the regranted options,
the  Compensation  Committee  believes that the program  strikes an  appropriate
balance   between  the  interests  of  the  option  holders  and  those  of  the
stockholders.  The lower exercise  prices in effect under the regranted  options
make  those  options  valuable  once  again to the  executive  officers  and key
employees  critical  to the  Company's  financial  performance.  However,  those
individuals  will enjoy the  benefits of the  regranted  options only if they in
fact remain in the Company's  employ and  contribute to the Company's  financial
success  and only if the current  trading  price of the stock is higher that the
exercise price of all regranted options.

      CEO  Compensation.  The annual base salary of Lisa A. Conte, the Company's
President,  Chief  Executive  Officer and Chief  Financial  Officer,  was set at
$311,537 for the 1998 fiscal  year,  as compared to $312,901 for the 1997 fiscal
year,  based on our  performance  review  of Ms.  Conte for  1997.  This  amount
includes $59,573 and $13,431 attributable to child care costs and family travel,
respectively.  In setting Ms. Conte's  compensation,  we considered the level of
experience  and unique  qualifications  Ms. Conte has brought to Shaman as Chief
Executive  Officer,  the Company's goals for which Ms. Conte had  responsibility
and the degree to which she helped the Company  attain  those  goals.  Among the
Company's accomplishments during 1998 which we felt Ms. Conte helped the Company
achieve  were the  generation  of resources  to support the  continued  clinical
development  of the Company's  products in human trials and  development  of new


                                       35
<PAGE>

product and industry  opportunities for Shaman's technology.  The base salary of
Ms.  Conte for the 1998  fiscal  year was at the 45th  percentile  of the salary
levels in effect for chief executive officers at the peer group companies.

      Deduction Limit for Executive Compensation.  As a result of Section 162(m)
of the Internal  Revenue Code,  which was enacted into law in 1993,  the Company
will not be allowed a federal  income tax  deduction  for  compensation  paid to
certain executive officers,  to the extent that compensation  exceeds $1 million
per officer in any one year.  This  limitation will be in effect for each fiscal
year of the  Company  beginning  after  December  31, 1993 and will apply to all
compensation paid to the covered  executive  officers which is not considered to
be  performance  based.   Compensation  which  qualifies  as   performance-based
compensation  will  not have to be  taken  into  account  for  purposes  of this
limitation.  The 1992 Plan has been structured so that any  compensation  deemed
paid in connection  with the exercise of stock  options  granted under that Plan
with an exercise  price equal to the fair market  value of the option  shares on
the grant date will qualify as performance-based compensation.

      We do not  expect  that  the  compensation  to be  paid  to the  Company's
executive officers for the 1999 fiscal year will exceed the $1 million limit per
officer.  Accordingly, we have decided at this time not to take any other action
to limit  or  restructure  the  elements  of cash  compensation  payable  to the
Company's  executive  officers.  We will  reconsider  this  decision  should the
individual  compensation  of any executive  officer ever approach the $1 million
level.

                                  Compensation Committee

                                    Herbert H. McDade, Jr.
                                    Adrian D.P. Bellamy




                                       36
<PAGE>


Compensation of Executive Officers

      The  following  table sets forth the  compensation  earned,  for  services
rendered in all  capacities  to the  Company,  for each of the last three fiscal
years by (i) the  Company's  Chief  Executive  Officer  and (ii) the four  other
highest paid  executive  officers  serving as such at the end of the 1998 fiscal
year whose salary and bonus for that fiscal year was in excess of $100,000.  The
individuals  named in the table will be  hereinafter  referred  to as the "Named
Officers." No other executive  officer who would otherwise have been included in
such  table on the  basis of fiscal  year 1998  salary  and  bonus  resigned  or
terminated employment during the year.


<TABLE>
                           SUMMARY COMPENSATION TABLE
<CAPTION>
                                                            Long-Term
                              Annual Compensation          Compensation
                         --------------------------------- ------------
                                                               Awards
                                                              ---------
                         ----------------------------------------------                                   
                                                 Other     Securities
   Name and                                      Annual    Underlying  All Other
   Principal               Salary                Compen-    Options/    Compen-
   Position       Year     ($)(1)    Bonus ($)   sation($)   SARS (#)  sation($)                   
- ----------------- ----   ----------  ---------  ----------  ---------  ---------
<S>               <C>    <C>         <C>        <C>         <C>        <C>

Lisa A. Conte     1998   311,537(2)    3,000(3)        --   2,045,000(4)    --
  President,      1997   312,901(5)   91,689(6)        --     295,000(4)    --
  Chief           1996   286,190(7)   53,000(8)        --     105,000(4)    --
  Executive
  Officer and
  Chief
  Financial
  Officer

Gerald M.         1998    243,015      3,000(3)       --     215,000       --
Reaven, M.D.      1997    239,114     25,000(9)       --          --       --
  Senior Vice     1996    227,878      3,000          --       5,000       --
  President,
  Medical and
  Clinical
  Advisor

Atul S.           1998    177,474      3,000(3)  125,531(11) 140,000  66,356(12)
Khandwala,        1997    226,031     20,000(9)       --          --  82,217(13)
Ph.D. (10)        1996    187,563      3,000      51,200(14) 125,000 106,399(15)
  Former  
  Senior Vice
  President,
  Development
  and Chief
  Regulatory
  Officer

Steven R. King,   1998    179,329      3,000(3)       --     148,810       --
Ph.D.             1997    176,202     40,000(9)       --          --       --
  Senior Vice     1996    171,822      3,000          --      55,000       --
  President,
  Ethnobotany
  and
  Conservation

James E.          1998    257,544      3,000(3)       --     125,000       --
Pennington,       1997     58,490     70,000(17)      --     125,000       --
M.D. (16)         1996         --         --          --          --       --
  Former
  Senior Vice
  President,
  Clinical
  Research and
  Chief Medical
  Officer

Laurie 
Peltier(18),      1998    152,654      3,000(3)       --      65,000  25,000(19)
Vice President,   1997     87,674     20,000(20)      --      55,000  19,223(21)
  Project         1996         --         --          --          --      --              
  Coordination                                      
                                                      
</TABLE>
- -----------------
(1)   Includes  amounts  deferred  under the  Company's  Internal  Revenue  Code
      Section 401(k) Plan and the Company's Section 125 Plan.
(2)   Includes  $59,573 and $13,431  attributable to child care costs and family
      travel, respectively.
(3)   Represents  all  employees  bonus  paid in  1998  for  achievement  of the
      Company's milestones in 1997.
(4)   Ms. Conte has surrendered all of her currently held options.
(5)   Includes  $61,214 and $27,287  attributable  to childcare costs and family
      travel, respectively.
(6)   Includes  $75,000 paid in 1998 for  achievement of milestones in 1997.
(7)   Includes  $49,646 and $16,858  attributable to child care costs and family
      travel, respectively.
(8)   Includes  $50,000 paid in 1997 for  achievement of milestones in 1996.
(9)   Represents  bonus paid in 1998 for  achievement of milestones in 1997.
(10)  The Company accepted the resignation of Dr. Khandwala  effective
      October 2, 1998.
(11)  Represents amount paid in Common Stock for services rendered.
(12)  Includes  $3,000 received as a housing  subsidy,  $2,018 for travel
      expenses  and  $61,338  for  indebtedness  for which  repayment  was
      forgiven.
(13)  Includes $16,500 received as a housing subsidy, $1,164 for travel expenses
      and $64,553 in indebtedness for which repayment was forgiven.
(14)  Represents fees received from consulting services.
(15)  Includes $13,445 received as a housing subsidy,  $23,746 for moving
      and  relocation  expenses,  $1,562  for  travel  expenses  and  $67,646 in
      indebtedness for which repayment was forgiven.
(16)  Dr.  Pennington  joined the Company in September  1997.  In 1997, he
      earned  $58,490,   based  on  an  annual  salary  of  $255,000.   Dr.
      Pennington  was  terminated  effective  February  19, 1999 due to the
      elimination  of  his  position  in  connection   with  the  Company's
      restructuring.
(17)  Includes  $60,000  sign-on bonus and $10,000 bonus paid in 1998 for
      achievement of milestones in 1997.
(18)  Ms.  Peltier  joined the Company in June 1997. In 1997,  she earned
      $87,674, based on an annual salary of $150,000.
(19)  Represents  closing  costs  on the  sale  of Ms.  Peltier's  former
      residence.


                                       37
<PAGE>

(20)  Includes  $10,000  sign-on  bonus and $10,000 bonus paid in 1998
      for achievement of milestones in 1997.
(21)  Represents moving and relocation expenses.

Stock Option and Stock Appreciation Rights

      The following  table  contains  information  concerning the grant of stock
options under the Plan to the Named Officers during the 1998 fiscal year. Except
for the limited stock  appreciation  right described in footnote (2) below which
formed  part  of  the  option  grant  made  to  each  Named  Officer,  no  stock
appreciation  rights were granted to such Named Officers  during the 1998 fiscal
year.

<TABLE>
                      OPTION/SAR GRANTS IN LAST FISCAL YEAR
<CAPTION>


                                                                  Potential Realizable Value at          
                                                               Assumed Annual Rates of  Stock Price  
                           Individual Grants                     Appreciation for Option Term (1)                         
             ----------------------------------------------  ----------------------------------------                              
                           % of Total         
              Number         Options         
              of             Granted      
              Securities       to            
              Underlying    Employees  Exercise       
              Options/SARs  in Fiscal   Price     Expiration     5%        5%       10%         10%    
 Name(*)      Granted(#)(2)   Year    ($/Share)(3)   Date     12/31/98   3/31/99  12/31/98    3/31/99
- ------------ -------------  ---------  ----------- ---------  --------   ------- ----------   -------
<S>          <C>            <C>        <C>         <C>        <C>        <C>     <C>          <C>    
Lisa A. Conte(4)   545,000   14.60%     1.2810    09/17/08    $439,059      0    $1,112,663      0 
                 1,500,000   40.19%     1.2810    09/17/08   1,208,421      0     3,062,376      0 
                                                                                                                
Gerald M.          215,000    5.76%     1.2810     09/17/08    173,207      0       438,941      0 
Reaven, M.D.    
                                                                                                                         
Atul S.             40,000    1.07%     1.4375     10/19/08      4,211      0         8,535      0 
Khandwala,                                                                                                   
Ph.D. (5) 
                                                                                        
Steven R.          148,810    3.99%     1.2810     09/17/08    119,883      0       303,808      0 
King, Ph.D.         
                                                                                                                            
James              125,000    3.35%     1.2810     09/17/08    100,702      0       255,198      0 
Pennington,                                                                                                   
M.D. (6)   

Laurie Peltier      55,000    1.47%     1.2810     09/17/08     44,309      0       112,287      0 
                    10,000    0.27%     1.2810     09/17/08      8,053      0        20,413      0 
                                                                                                
</TABLE>
- -----------------
(1)   Potential realizable value is based on assumption that the market price of
      the  Common  Stock  appreciates  at  the  annual  rate  shown  (compounded
      annually) from the date of grant until the end of the 10-year option term.
      There can be no assurance  that the actual stock price  appreciation  over
      the 10-year option term will be at the assumed 5% and 10% levels or at any
      other  defined  level.  As of March 31, 1999 the  exercise  price  of all 
      options  was significantly higher than the trading price of the stock on 
      that date.

(2)   Each option has a maximum term of 10 years, subject to earlier termination
      in the event of the  optionee's  cessation  of service  with the  Company.
      Except for the options for 1,500,000  shares granted to Ms. Conte,  40,000
      shares granted to Mr.  Khandwala and 10,000 shares granted to Ms. Peltier,
      each option  granted to the Named Officers in fiscal 1998 were part of the
      September 18,1998 cancellation/regrant program. Accordingly, to the extent
      the cancelled option for the same number of shares was exercisable for any
      of those  shares on the  September  18, 1998  cancellation  date,  the new
      option granted in replacement of that option will become  exercisable  for
      those shares in a series of 12 successive equal monthly  installments upon
      his or her  completion  of each month of service over the one-year  period
      measured from the  September  18, 1998 grant date.  The option will become
      exercisable  for the remaining  option shares in one or more  installments
      over her period of continued  service,  with each such installment to vest
      on the  same  vesting  date in  effect  for  that  installment  under  the
      cancelled option. The options for 1,500,000 shares to Ms. Conte and 10,000
      shares to Ms. Peltier will will become exercisable for 12.5% of the option
      shares  upon  completion  of 6 months of service  measured  from the grant
      date,  and the balance of the option shares will become  exercisable  in a
      series of 42 successive  equal monthly  installments  over the  optionee's
      period of continued  service  thereafter.  The Option for 40,000 shares to
      Mr. Khandwala will become  exercisable in a series of six successive equal
      monthly  installments  over the  optionee's  period of  continued  service
      thereafter.  However,  each of the options  granted to the named executive
      officers will become  immediately  exercisable in full upon an acquisition
      of the  Company by merger or asset  sale,  unless the option is assumed by
      the successor  entity.  Each option includes a limited stock  appreciation
      right which will result in the cancellation of that option,  to the extent
      exercisable for vested shares, upon the successful completion of a hostile
      tender for  securities  possessing  more than 50% of the  combined  voting
      power of the Company's  outstanding voting  securities.  In return for the
      cancelled  option,  the  optionee  will  receive a cash  distribution  per
      cancelled  option share equal to the excess of (i) the highest  price paid
      per share of the Company's  Common Stock in such hostile tender offer over
      (ii) the exercise price payable per share under the cancelled option.

(3)   The  exercise  price  may be paid in cash or in  shares  of  Common  Stock
      (valued at fair market value on the  exercise  date) or through a cashless
      exercise procedure  involving a same-day sale of the purchased shares. The
      Company  may also  finance the option  exercise  by loaning  the  optionee

                                       38
<PAGE>
      
      sufficient  funds to pay the exercise  price for the purchased  shares and
      the federal and state  income tax  liability  incurred by the  optionee in
      connection with such exercise.  The optionee may be permitted,  subject to
      the approval of the Plan  Administrator,  to apply a portion of the shares
      purchased under the option (or to deliver existing shares of Common Stock)
      in satisfaction of such tax liability. 

(4)   Ms. Conte has surrendered all of her currently held options.

(5)   The Company accepted the resignation of Dr. Khandwala  effective
      October 2, 1998.

(6)   Dr.  Pennington  was  terminated  effective  February  19, 1999 due to the
      elimination   of  his   position   in   connection   with  the   Company's
      restructuring.

Option Exercises and Holdings

      The  following  table  provides  information  with  respect  to the  Named
Officers  concerning  the  exercise  of options  during the last fiscal year and
unexercised  options  held as of the end of the fiscal year (as of December  31,
1998). No stock appreciation  rights were exercised during such fiscal year, and
except for the limited stock appreciation right described in Footnote (2) to the
Stock Option/SAR Grants Table which forms part of each outstanding stock option,
no stock appreciation rights were outstanding at the end of that fiscal year.


<TABLE>
                 AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                            AND FY-END OPTION VALUES
<CAPTION>


                     Value                               
                    Realized                             Value of Unexcercised     
                    (Market                               In-the-Money Options 
                    price at                               at FY-End (Market    
           Shares   exercise     No. of Securities         price of shares at               
          Acquired  date less  Underlying Unexcersied    FY-End less excercise            
             on     exercise     Options FY-End (#)          price) ($)(1)      
Name      Exercise  price)  ------------------------- --------------------------   
             (#)     ($)(2) Exercisable Unexercisable  Exercisable Unexercisable 
- ------------ ------- -----  ----------- -------------  ----------- -------------
<S>          <C>     <C>    <C>         <C>           <C>          <C>       
Lisa A.         --      --    95,417      2,024,583     $130,961     $1,265,364
Conte(3)

Gerald M.       --      --    53,750        161,250      $33,594       $100,781
Reaven, M.D.

Atul S.         --      --    13,333         26,667       $6,247        $12,493
Khandwala,
Ph.D. (4)

Steven R.       --      --    41,500        112,957      $25,902        $70,598
King, Ph.D.

James           --      --    15,625        109,375       $9,766        $68,359
Pennington,
M.D. (5)

Laurie          --      --     5,625         59,375       $3,516        $37,106
Peltier

</TABLE>
- -----------------
(1)   Based on the fair market value of the  Company's  Common Stock on December
      31, 1998 of $1.906 per share,  the Nasdaq National Market trading price at
      the close of business that same day. As of March 31, 1999, these options 
      had no value since the exercise price of all options was significantly  
      higher than the current trading price of the stock on that date.

(2)   Equal to the closing  selling price of the purchased  shares on the option
      exercise date less the exercise price paid for such shares.

(3)   Ms. Conte has surrendered all of her currently held options.

(4)   The Company accepted the resignation of Dr. Khandwala  effective
      October 2, 1998.

(5)   Dr.  Pennington  was  terminated  effective  February  19, 1999 due to the
      elimination   of  his   position   in   connection   with  the   Company's
      restructuring.




                                       39
<PAGE>


                                Option Repricings

      As  discussed   in  the   Compensation   Committee   Report  on  Executive
Compensation    below,    the    Company    implemented    a   special    option
cancellation/regrant  program  for  all of its  employees,  including  executive
officers,  holding stock  options with an exercise  price per share in excess of
the fair market value of the  Company's  Common Stock on the regrant  date.  The
cancellations/regrants  were  effected on September  18,  1998,  and a number of
outstanding  options  with an exercise  price in excess of $1.281 per share were
surrendered for  cancellation  and new options for the same aggregate  number of
shares were granted with an exercise price of $1.281 per share.

      The  following  table sets forth  information  with respect to each of the
Named   Officers   concerning   his  or   her   participation   in  the   option
cancellation/regrant program effected on September 18, 1998. The Company has not
implemented  any  other  option  cancellation/regrant   programs  in  which  the
Company's executive officers have participated



<TABLE>
<CAPTION>
                             Number of    Market                      Length of  
                            Securities   Price of   Excercise        Option Term   
                            Underlying   Stock at   Price at        Remaining at
                              Options    Time of    Time of            Date of
                             Repriced   Repricing  Repricing    New    Repricing
                   Repricing     or        or         or     Excercise    or       
    Name             Date    Amended(1) Amendment  Amendment   Price   Amendment
- ------------------ --------- ---------- ---------  --------- --------- ---------
<S>                <C>       <C>        <C>        <C>       <C>       <C>      
Lisa A. Conte(2)    9/18/98    10,000    $1.281    $3.500   $1.281     6.4 years
                    9/18/98   135,000     1.281     3.500    1.281     6.4 years  
                    9/18/98   100,000     1.281     6.875    1.281     7.4 years
                    9/18/98     5,000     1.281     5.875    1.281     8.1 years
                    9/18/98   295,000     1.281     5.016    1.281     8.4 years

Gerald M.           9/18/98   200,000    $1.281    $3.625   $1.281     6.4 years
  Reaven, M.D       9/18/98    10,000     1.281     3.500    1.281     6.4 years
                    9/18/98     5,000     1.281     5.875    1.281     8.1 years

Atul S. Khandwala,      ---       ---       ---       ---      ---           ---
  Ph.D.(3)

Steven R. King,     9/18/98    35,000    $1.281    $5.250   $1.281     6.2 years
  Ph.D              9/18/98    25,000     1.281     3.500    1.281     6.4 years
                    9/18/98    23,810     1.281     3.500    1.281     6.4 years
                    9/18/98    10,000     1.281     3.500    1.281     6.4 years
                    9/18/98    50,000     1.281     6.875    1.281     7.4 years
                    9/18/98     5,000     1.281     5.875    1.281     8.1 years

James Pennington,   9/18/98   125,000    $1.281    $6.063   $1.281     9.0 years
  M.D.(4)

Laurie Peltier      9/18/98    40,000    $1.281    $5.938   $1.281     8.8 years
                    9/18/98    15,000     1.281     5.938    1.281     8.8 years

</TABLE>
- ----------------------
(1)   As of March 31, 1999, the exercise price of the options was significantly
      higher than the  trading  price of the stock on that date.

(2)   Ms. Conte has surrendered all of her currently held options.

(3)   The Company accepted the resignation of Dr. Khandwala effective
      October 2, 1998.

(4)   Dr.  Pennington  was  terminated  effective  February  19, 1999 due to the
      elimination   of  his   position   in   connection   with  the   Company's
      restructuring.


Employment  Contracts,  Termination  Agreements  and  Change of Control
Agreements

      On March 15,  1999,  the Board of  Directors  approved a Change in Control
provision  concerning  severance  benefits for key  executives.  Pursuant to the
provision,  should their employment with the Company  terminate within 12 months
after a Change in  Control,  for any reason  other than for cause,  they will be
entitled to receive in one lump sum payment the cash  equivalent of 12 months of
base salary plus any  benefits to which they would  otherwise  be  entitled.  In
connection  with these  severance  benefits,  the  Company has agreed to pay the
premiums for any COBRA  coverage to which these  individuals  or their spouse or
dependents are entitled under a Company sponsored medical plan after a Change in
Control.  In addition,  in the event of a Change in Control,  all of the options
held  by  such key  executives  will  automatically  become  fully  vested  and


                                       40
<PAGE>


exercisable.   Such  executives'   exercisable  shares  will  be  fixed  at  the
termination  of their  employment,  and they  will have a period of 90 days from
their termination date to purchase such exercisable  shares, as set forth in the
stock option agreements applicable to their options.

      On May  27,  1998,  the  Company  entered  into a  letter  agreement  with
Stephanie  C.  Diaz  pursuant  to which  she  served  as Vice  President,  Chief
Financial  Officer,  commencing in June 1998.  Pursuant to the letter agreement,
Ms. Diaz was paid an annual salary of $135,000 in addition to a $15,000  sign-on
bonus.  In addition,  Ms. Diaz was granted an option for 45,000 shares of Common
Stock on June 30,  1998 with an  exercise  price per share of  $3.375,  the fair
market  value  per  share  of  Common  Stock on that  date.  The  option  became
exercisable  for 12.5% of the option  shares  upon  completion  of six months of
employment  and for  the  balance  of the  option  shares  in 42  equal  monthly
installments  over the next 42 months of  employment.  In the event the  Company
terminated Ms. Diaz's employment other than for cause, she was to be paid salary
and  benefits  for six  months  or  until  she  obtained  full-time  employment,
whichever occurs first. Ms. Diaz resigned from the Company  effective January 4,
1999. In  connection  with a revised  agreement,  Ms. Diaz received a payment of
three months salary and the  continuance  of the exercise  period under existing
options for a period of 12 months following termination of her employment.

      On March 30, 1998, the Company  entered into a letter  agreement with John
W.S. Chow, Ph.D.  pursuant to which he is to serve as Vice President,  Technical
Operations,  commencing in May 1998. Pursuant to the letter agreement,  Dr. Chow
is to be paid an annual salary of $165,000 in addition to the sign-on bonus paid
to him in the amount of $10,000, and he is to be reimbursed, in an amount not to
exceed $25,000,  for closing costs incurred in the sale of his former  residence
in New Jersey and the purchase of his new  residence  in the Bay Area.  Dr. Chow
will,  however,  be  obligated  to repay a prorated  portion of both the sign-on
bonus and the reimbursed  closing costs should he resign from the Company within
two years after his hire date.  Dr.  Chow was also  granted an option for 50,000
shares  of Common  Stock on May 15,  1998  with an  exercise  price per share of
$4.9375,  the fair  market  value per share of Common  Stock on that  date.  The
option will become exercisable in a series of monthly installments over the four
year period  measured  from the grant date as follows:  10% of the option shares
will become exercisable upon his completion of six months of employment measured
from such grant  date,  an  additional  30% of the  option  shares  will  become
exercisable  in a series of 18 successive  equal monthly  installments  upon his
completion  of each  additional  month of  employment  over  the next 18  months
thereafter,  and the remaining 60% of the option shares will become  exercisable
in a series of 24 successive equal monthly  installments  upon his completion of
each additional  month of employment  during the 3rd and 4th years of employment
measured  from the grant date.  Dr. Chow was also granted an  additional  15,000
shares of Common  Stock on May 15, 1998 with an exercise  price of $4.9375,  the
fair market value per share of Common Stock on that date. The 15,000-share grant
will become  exercisable as follows:  7,500 shares upon Dr. Chow's completion of
three years of employment  measured from the grant date, and the remaining 7,500
shares upon his  completion of four years of employment  measured from the grant
date. The Company further agreed to pay Dr. Chow's reasonable moving expenses in
an amount not to exceed  $20,000 and to provide him with an apartment  for up to
four  months at a rental  not to exceed  $2,500 per  month.  Should the  Company
terminate Dr. Chow's employment for any reason other than for cause prior to May
1, 2001,  the Company will  continue to pay Dr. Chow's base salary plus benefits
on a monthly basis for up to six months or until Dr. Chow obtains near full-time
employment or consulting of at least 80% of his time,  whichever  occurs sooner.
The Company also  extended a $300,000  loan to Dr. Chow in  connection  with his
purchase of a new  residence  in the Bay Area.  See "Certain  Relationships  and
Related Transactions."

      On August 21, 1997, the Company entered into a letter agreement with James
Pennington,  Ph.D.  pursuant to which he is to serve as Senior  Vice  President,
Clinical Research and Chief Medical Officer,  commencing October 1997.  Pursuant
to the  letter  agreement,  Dr.  Pennington  is to be paid an  annual  salary of
$255,000 in addition to a sign-on bonus paid to him in the amount of $60,000. In
addition,  Dr.  Pennington  was  granted,  on September  16, 1997,  an option to
purchase  125,000  shares of Common  Stock at a purchase  price of  $6.0625  per
share.  The  option  had a term of 10 years  and was to  become  exercisable  as
follows:  12.5% of the option  shares upon Dr.  Pennington's  completion  of six
months of service,  measured from the grant date,  and the balance of the option
shares in 42 successive equal monthly  installments  upon his completion of each
of the next 42 months of  service  thereafter.  In the  event  that the  Company
terminated  Dr.  Pennington's  employment  other  than  for  cause,  he would be
entitled to receive  salary and benefits for nine months,  or, if sooner,  until
Dr. Pennington  obtained near full time employment or consulting of at least 80%
of his time.  On February 15, 1999,  the Company  entered into an new  agreement
with Dr. Pennington in connection with his resignation as Senior Vice President,
Clinical Research and Chief Medical Officer,  effective February 19, 1999. Under
this  agreement,  payments  will  continue  to be  made  to  Dr.  Pennington  in



                                       41
<PAGE>

compliance with the terms of the agreement described above. In addition, options
previously granted to him will continue to vest during this period following his
termination.

      On February 9, 1996, the Company entered into a letter agreement with Atul
S.  Khandwala,  Ph.D.  pursuant  to  which  served  as  Senior  Vice  President,
Development,  commencing  March  1996.  Pursuant  to the letter  agreement,  Dr.
Khandwala was paid an annual salary of $225,000. In addition,  Dr. Khandwala was
granted an option to purchase 120,000 shares of Common Stock at a purchase price
of $6.875  per  share.  The  option  had a term of ten  years  and would  become
exercisable  over a four-year  period in a series of 48 successive equal monthly
installments upon Dr.  Khandwala's  completion of each month of service with the
Company over the four-year period measured from March 1, 1996. In the event that
the Company terminated Dr. Khandwala's  employment for any reason, Dr. Khandwala
would  receive  salary and  benefits  for a period of six months.  On August 24,
1998,  the Company  entered  into a severance  agreement  with Dr.  Khandwala in
connection with his resignation as Senior Vice President,  Development and Chief
Regulatory  Officer on October 2, 1998.  Under this agreement,  the Company will
continue to forgive the remaining balance of his loan over the remaining two and
one half  years of the loan  term,  provided  that Dr.  Khandwala  continues  to
provide  consulting  services to the Company.  On October 28, 1998,  the Company
entered  into an  agreement  with Dr.  Khandwala  pursuant  to which he rendered
consulting  services to the Company  through April 2, 1999.  In connection  with
this  agreement,  the Company  issued to Dr.  Khandwala  87,326 shares of Common
Stock and  loaned  him the funds  necessary  to satisfy  the  federal  and state
withholding taxes applicable to those shares.  In addition,  the Company granted
Dr. Khandwala an option to purchase 40,000 shares of Common Stock at an exercise
price of $1.4375, the fair market value of the Company's Common Stock on October
20,1998.  The option will become  exercisable  in six  successive  equal monthly
installments on the last day of each month during the Consulting Period.

      None of the Company's other executive officers have employment  agreements
with the Company,  and their  employment  may be  terminated  at any time at the
discretion  of the  Board  of  Directors.  As  administrator  of the  Plan,  the
Compensation  Committee has the authority to provide for accelerated  vesting of
the shares of Common Stock subject to any outstanding  options held by the Chief
Executive  Officer and the Company's  other  executive  officers or any unvested
shares  actually  held by those  individuals  under  the Plan  upon a change  in
control of the Company effected through a successful  tender offer for more than
50% of the Company's  outstanding  voting  securities or through a change in the
majority of the Board as a result of one or more  contested  elections for Board
membership.

Certain Relationships and Related Transactions

      On June 17, 1998,  the Company loaned  $300,000 to John W.S. Chow,  Ph.D.,
the Vice  President,  Technical  Operations,  to reimburse  him for a reasonable
difference  between the purchase  price of his residence in the Bay Area and the
cost of comparable  housing in New Jersey,  his former state of  residence.  The
loan is evidenced by his promissory  note of the same date which will become due
and payable in a series of five successive equal annual  installments,  with the
first such  installment  due on June 25, 1999.  The note will bear interest at a
variable  per annum  rate equal to the  short-term  applicable  federal  rate in
effect  under the federal tax laws for  January of each  calendar  year the loan
remains outstanding. Accordingly, the interest rate in effect for the period Dr.
Chow's note was outstanding during the 1998 calendar year was 5.52%. Accrued and
unpaid  interest  will  become  due and  payable  each year on the same date the
principal  installment  for that  year  becomes  payable.  Each  installment  of
principal  and  accrued   interest  will   automatically  be  forgiven  as  that
installment  becomes due,  provided Dr. Chow continues in the Company's  employ.
However,  the entire unpaid  balance of the note,  together with all accrued and
unpaid  interest,  will  become  immediately  due and  payable  upon Dr.  Chow's
termination  of employment  with the Company prior to June 25, 2003,  unless Dr.
Chow's  employment  is  involuntarily  terminated  by the Company other than for
cause.  In the event (i) the Company  terminates  Dr. Chow's  employment for any
reason other than for cause or (ii) Dr. Chow's  employment  terminates by reason
of his death or disability,  then the entire principal  balance of the note plus
accrued  interest will be forgiven.  The amount  outstanding  on Dr. Chow's note
(including accrued interest) was approximately $313,188 as of March 31, 1999; 
and the highest amount outstanding on that note during the 1998 fiscal year was
$308,729.

      See "Employment  Contracts,  Termination  Agreements and Change of Control
Agreements"  and "Director  Compensation"  with respect to further  transactions
between the Company and its officers and directors.



                                       42
<PAGE>

      The Company's Restated Certificate of Incorporation and Bylaws provide for
indemnification of directors,  officers and other agents of the Company. Each of
the current  directors  and  certain  officers  and agents of the  Company  have
entered into separate indemnification agreements with the Company.




                                       43
<PAGE>




                      SECURITY OWNERSHIP OF MANAGEMENT AND
                            CERTAIN BENEFICIAL OWNERS

      The following  table sets forth certain  information  known to the Company
with  respect to the  beneficial  ownership  of the Common Stock as of March 31,
1999 by (i) all persons who are beneficial owners of five percent or more of the
Common  Stock,  (ii) each  director,  (iii) the Named  Officers  in the  Summary
Compensation  Table above and (iv) all current directors and executive  officers
as a  group.  The  number  of  shares  beneficially  owned by each  director  or
executive  officer is determined  under rules of the SEC and the  information is
not necessarily indicative of beneficial ownership for any other purpose. Shares
of Common  Stock  subject  to  options  or  warrants  currently  exercisable  or
exercisable within 60 days of March 31, 1999 are deemed to be beneficially owned
by the person  holding  such  option or warrant  for  computing  the  percentage
ownership of such person,  but are not treated as outstanding  for computing the
percentage  of any other  person.  Except as  otherwise  indicated,  the Company
believes that the beneficial owners of the Common Stock listed below, based upon
such  information  furnished by such  owners,  have sole  investment  power with
respect to such shares, subject to community property laws where applicable.


<TABLE>
<CAPTION>
                                         Number of       Percent of Total Shares
           Name and Address                Shares          Outstanding (1)(2)
- -------------------------------------  ---------------  ------------------------
<S>                                    <C>              <C>                   
Vulcan Ventures, Inc. (3)..........        2,080,000             5.43%
  110 110th Avenue N.W.
  Suite 550
  Bellevue, WA  98004
Lisa A. Conte (4)..................          883,292             2.28%
Steven R. King, Ph.D. (5)..........          111,745                *
James E. Pennington, M.D. (6)......           41,667                *
Gerald R. Reaven, M.D. (7).........          143,833                *
John Chow (8)......................           14,166                *
J.D. Haldeman (9)..................           14,445                *
Laurie Peltier (10)................           16,667                *
Atul S. Khandwala, Ph.D. (11)......           40,000                *
Thomas Carlson, M.D. (12)..........           61,172                *
G. Kirk Raab (13)..................          310,032                *
Adrian D.P. Bellamy (14)...........           19,583                *
Jeffrey Berg (15)..................            4,167                *
Herbert H. McDade, Jr. (16)........           40,532                *
M. David Titus (17)................           38,451                *
Current Officers and Directors as          
a group (18)
(12 persons).......................        1,658,085             4.21%

</TABLE>
- ----------------------
*....Less than 1.0%


(1)   Percentage  of  beneficial  ownership is  calculated  assuming  38,337,156
      shares of Common Stock were  outstanding as of March 31, 1999.  Beneficial
      ownership is determined in accordance with the rules of the Securities and
      Exchange Commission and generally includes voting or investment power with
      respect  to  securities.  Shares of Common  Stock  subject  to  options or
      warrants   currently   exercisable  or  convertible,   or  exercisable  or
      convertible  within 60 days of March 31, 1999, are deemed  outstanding for
      computing the  percentage of the person holding such option or warrant but
      are not deemed  outstanding  for  computing  the  percentage  of any other
      person. Except as indicated in the footnotes to this table and pursuant to
      applicable  community  property  laws, the persons named in the table have
      sole  voting and  investment  power  with  respect to all shares of Common
      Stock beneficially owned.

(2)   This table is based upon information  supplied to the Company by executive
      officers,  directors and stockholders owning greater than five percent, as
      set forth in filings required by the Securities and Exchange Commission or
      as otherwise provided. The address of each officer and director identified
      in this table is that of the Company's  executive offices,  213 East Grand
      Avenue,  South San Francisco,  CA 94080. Unless otherwise indicated in the



                                       44
<PAGE>

      footnotes to this table and subject to applicable community property laws,
      each  of the  stockholders  named  in  this  table  has  sole  voting  and
      investment power with respect to the shares shown as beneficially owned by
      it, him or her.

(3)   Does not  include  20,000  shares of  Series C  Preferred  Stock  which is
      convertible  into shares of Common Stock,  such number which is determined
      in accordance with that certain Series C Stock Purchase Agreement.

(4)   Includes 420,992 shares subject to options  exercisable  within 60 days of
      March 31, 1999.

(5)   Includes  96,487 shares subject to options  exercisable  within 60 days of
      March 31, 1999.

(6)   Represents shares subject to options  exercisable within 60 days
      of March 31, 1999.

(7)   Includes 143,333 shares subject to options  exercisable  within 60 days of
      March 31, 1999.

(8)   Represents shares subject to options  exercisable within 60 days
      of March 31, 1999.

(9)   Represents shares subject to options  exercisable within 60 days
      of March 31, 1999.

(10)  Represents shares subject to options  exercisable  within 60 days of March
      31, 1999.

(11)  Represents shares subject to options  exercisable within 60 days of March
      31, 1999. Dr.  Khandwala  resigned from the Company in October 1998.

(12)  Represents shares subject to options  exercisable  within 60 days of March
      31, 1999.

(13)  Includes 174,380 shares subject to options  exercisable  within 60 days of
      March 31, 1999.  Does not include 1,500 shares of Series C Preferred Stock
      which is convertible  to a certain number of shares of Common Stock,  such
      number which is determined in accordance  with that certain Series C Stock
      Purchase Agreement.

(14)  Represents shares subject to options  exercisable  within 60 days of March
      31, 1999.

(15)  Represents shares subject to options  exercisable  within 60 days of March
      31, 1999.

(16)  Represents shares subject to options  exercisable  within 60 days of March
      31, 1999.

(17)  Includes  33,451 shares subject to options  exercisable  within 60 days of
      March 31, 1999.

(18)  Includes  shares held by family  members  associated  with  directors  and
      officers listed above. Also includes  1,039,375 shares which are currently
      issuable upon the exercise of outstanding options.



                                       45
<PAGE>


Stock Performance Graph

      The graph below  depicts the  Company's  stock price as an index  assuming
$100  invested  on January 26, 1993 (the date of the  Company's  initial  public
offering),  along with the composite prices of companies listed in the Hambrecht
& Quist  Biotechnology  Index and Nasdaq  Total U.S.  Stock Market  Index.  This
information  has  been  provided  to the  Company  by  Hambrecht  &  Quist.  The
comparisons  in the graph are  required by  regulations  of the  Securities  and
Exchange  Commission and are not intended to forecast or to be indicative of the
possible future performance of the Common Stock.

         COMPARISON OF CUMULATIVE TOTAL RETURN SINCE JANUARY 26, 1993**
                       Among Shaman Pharmaceuticals, Inc.,
                  the Hambrecht & Quist Biotechnology Index and
                      The Nasdaq Stock Market - U.S. Index


                               PERFORMANCE GRAPH


** $100 invested on January 26, 1993 in stock or index,  including  reinvestment
of dividends.

      Notwithstanding anything to the contrary set forth in any of the Company's
previous filings under the Securities Act of 1933, as amended, or the Securities
Exchange Act of 1934, as amended, which might incorporate future filings made by
the Company under those statutes, the preceding Compensation Committee Report on
Executive  Compensation  and the  Company  Stock  Performance  Graph will not be
incorporated by reference into any of those prior filings,  nor will such report
or graph be  incorporated  by  reference  into any  future  filings  made by the
Company under those Acts.



                                       46
<PAGE>


 
                        COMPLIANCE WITH SECTION 16(a) OF
                       THE SECURITIES EXCHANGE ACT OF 1934



      Section 16(a) of the Securities Exchange Act of 1934, as amended, requires
the Company's  officers,  directors and persons who are the beneficial owners of
more than 10% of the  Common  Stock to file  initial  reports of  ownership  and
reports of  changes in  ownership  of the  Common  Stock with the United  States
Securities and Exchange Commission ("SEC"). Officers, directors and greater than
10%  stockholders  are required by SEC  regulations  to furnish the Company with
copies of all Section 16(a) forms they file.

     Based  solely on its review of the copies of such  forms  furnished  to the
Company and the written representations that no other reports were required, the
Company  believes  that,  during the period from January 1, 1998 to December 31,
1998,  all  officers,  directors and  beneficial  owners of more than 10% of the
Common Stock complied with all Section 16(a)  requirements,  except as described
herein.  Each of Dr.  Chow and Ms.  Diaz did not timely  file his or her Form 3,
each of which untimely filings was subsequently  corrected.  Each of Mr. McDade,
Mr. Bellamy,  Mr. Raab and Mr. Titus did not timely file a Form 4 for the option
grant on May 15, 1998, which untimely filing was subsequently corrected. Each of
Mr. Berg, Mr. Raab, Mr. Titus, Ms. Conte, Dr. Reaven,  Dr. King, Dr. Pennington,
Ms.  Peltier,  Dr.  Chow and Ms.  Haldeman  was late in  filing a Form 5,  which
untimely filing was subsequently corrected.


                  DEADLINE FOR RECEIPT OF STOCKHOLDER PROPOSALS



      Proposals of stockholders of the Company that are intended to be presented
by such  stockholders  at the Company's  2000 Annual Meeting must be received by
the Company no later than  December ___, 1999 in order that they may be included
in the proxy statement and form of proxy relating to that meeting.

      In addition,  the proxy  solicited for the 2000 Annual Meeting will confer
discretionary  authority to vote on any stockholder  proposals presented at that
meeting,  unless the Company is provided  with notice of such  proposal no later
than ___________, 2000.


                                  ANNUAL REPORT



      A copy of the Company's  Annual Report to Stockholders  for the year ended
December 31, 1998 has been mailed  concurrently with this Proxy Statement to all
stockholders entitled to notice of and to vote at the Annual Meeting. The Annual
Report is not incorporated into this Proxy Statement and is not considered proxy
soliciting material.


                                    FORM 10-K



      The Company  filed an Annual Report on Form 10-K with the  Securities  and
Exchange Commission.  A copy of this report may be obtained,  without charge, by
writing to Investor  Relations,  Shaman  Pharmaceuticals,  Inc.,  213 East Grand
Avenue, South San Francisco, California 94080.



                                       47
<PAGE>

                                  OTHER MATTERS


      The  Company  knows  of no  other  matters  that  will  be  presented  for
consideration  at the Annual Meeting.  If any other matters properly come before
the Annual  Meeting,  it is the  intention of the persons  named in the enclosed
form of Proxy to vote the  shares  they  represent  as the Board may  recommend.
Discretionary  authority  with  respect to such other  matters is granted by the
execution of the enclosed Proxy.




                                    THE BOARD OF DIRECTORS

Dated:  May ___, 1999



                                       48
<PAGE>



                                                       Appendix A



                              AMENDED AND RESTATED
                          CERTIFICATE OF INCORPORATION
                         OF SHAMAN PHARMACEUTICALS, INC.
                             a Delaware Corporation



           SHAMAN  PHARMACEUTICALS,  INC., a corporation  organized and existing
under the laws of the State of Delaware, hereby certifies as follows:

           1. The name of this corporation is Shaman  Pharmaceuticals,  Inc. The
original  Certificate of  Incorporation  of the  corporation  was filed with the
Secretary of State of the State of Delaware on December 21, 1992.

           2. The Amended and Restated  Certificate  of  Incorporation  has been
duly adopted by its Board of Directors and  stockholders  in accordance with the
provisions of Sections 242 and 245 of the General  Corporation  Law of the State
of Delaware.

           3. The text of the Restated  Certificate of  Incorporation is  hereby
restated toread in its entirety as follows:


                                    ARTICLE I

           The name of this corporation is Shaman Pharmaceuticals, Inc.


                                   ARTICLE II

           The address of the registered  office of the corporation in the State
of Delaware  is 1209 Orange  Street,  in the City of  Wilmington,  County of New
Castle.  The name of its  registered  agent at such  address is The  Corporation
Trust Company.


                                   ARTICLE III

           The nature of the business or purposes to be conducted or promoted is
to engage in any lawful act or activity for which  corporations may be organized
under General Corporation Law of Delaware.

                                   ARTICLE IV

     A. Classes of Stock.  The Corporation is authorized to issue two classes of
shares to be  designated,  respectively,  Common Stock  ("Common") and Preferred
Stock  ("Preferred").  The total number of shares of Preferred  the  corporation
shall  have  authority  to issue is  12,000,000  with a par value of $0.001  per
share,



                                       
<PAGE>

and the total number of shares of Common the corporation shall have authority to
issue is 220,000,000 with a par value of $0.001 per share.

         Upon  the  filing  of  this  Amended  and  Restated  Certificate  of 
Incorporation,  each  outstanding  20  shares  of  Common  Stock  shall  be
converted  into one share of Common  Stock (the "Stock  Split").  No  fractional
shares of Common  Stock  shall be issued  upon the Stock  Split.  In lieu of any
fractional  shares  to  which  a  holder  would  otherwise  be  entitled  (after
aggregating  all such shares of Common Stock to which such holder is  entitled),
the Corporation shall issue to such holder one share of Common Stock.

      B. Rights,  Preferences  and  Restrictions  of  Preferred.  The  Preferred
authorized  by this Amended and Restated  Certificate  of  Incorporation  may be
issued from time to time in series.  The Board of Directors is hereby authorized
to fix or alter the rights, preferences,  privileges and restrictions granted to
or imposed upon any  authorized  series of  Preferred,  and the number of shares
constituting  any such series and the  designation  thereof,  or of any of them.
Subject to  compliance  with  applicable  protective  voting rights which may be
granted to the holders of the  Preferred or series  thereof in  Certificates  of
Designation or in the corporation's Certificate of Incorporation, as amended and
restated from time to time, and  requirements and restrictions of applicable law
("Protective Provisions"), the rights, privileges,  preferences and restrictions
of  any  such  additional  series  may  be  subordinated  to,  pari  passu  with
(including,  without  limitation,   inclusion  in  provisions  with  respect  to
liquidation and acquisition  preferences,  redemption and/or approval of matters
by vote or written consent),  or senior to any of those of any present or future
class or series of Preferred or Common.  Subject to compliance  with  applicable
Protective Provisions,  the Board of Directors is also authorized to increase or
decrease the number of shares of any series, prior or subsequent to the issue of
that series, but not below the number of shares of such series then outstanding.
In case the number of shares of any  series  shall be so  decreased,  the shares
constituting  such decrease  shall resume the status which they had prior to the
adoption  of the  resolution  originally  fixing  the  number  of shares of such
series.

           The  number of shares  constituting  the  Series A  Preferred  Stock,
$0.001 par value per share, shall be Four Hundred Thousand (400,000) shares. The
number of shares  constituting  Series C  Preferred  Stock  shall be Two Hundred
Thousand  (200,000)  shares,  $0.001 par value per  share.  The number of shares
constituting  the Series D Convertible  Preferred Stock (the "Series D Preferred
Stock") shall be Six Thousand Two Hundred Eighty-five (6,285) shares, $0.001 par
value per share and shall not be subject to increase.  The Corporation shall not
issue any shares of Series D Preferred  Stock after the Issuance  Date  (defined
below), except that on or prior to May 31, 1999, the corporation may issue up to
1,500  shares  of  Series  D  Preferred   Stock  to  MMC/GATX  in  exchange  for
indebtedness  of the corporation to MMC/GATX on a basis of one share of Series D
Preferred Stock for each $1,000 of such indebtedness.  The Board of Directors is
also  authorized to decrease  number of shares of any series of preferred  stock
prior or subsequent  to the issue of the Series A Preferred  Stock but not below
the  number of shares of such  series  then  outstanding.  In case the number of
shares  of any  series  shall be so  decreased,  the  shares  constituting  such
decrease  shall  resume the status  which they had prior to the  adoption of the
resolution originally fixing the number of shares of such series.



                                       2
<PAGE>

           The rights, preferences,  privileges, and restrictions granted to and
imposed on the Series A Preferred  Stock,  the Series C Preferred Stock, and the
Series D Preferred Stock are as set forth below in this Article IV(B).

           1.   Certain  Defined Terms.  The  following terms shall have  the  
following meanings as used in this  Article  IV(B)  (such meanings to be equally
applicable  to both the singular and plural forms of the terms defined):

           "Adjustment  Notice" means an Adjustment Notice  substantially in the
form set forth in Section 14(f).

           "Affiliate"  means, with respect to any Person, any other Person that
directly,  or  indirectly  through  one or  more  intermediaries,  controls,  is
controlled by, or is under common control with, the subject Person. For purposes
of the term "Affiliate," the term "control"  (including the terms "controlling,"
"controlled by" and "under common control with") means the possession, direct or
indirect, of the power to direct or to cause the direction of the management and
policies of a Person,  whether through the ownership of securities,  by contract
or otherwise.

           "Aggregated  Person"  means,  with respect to any holder of shares of
Series D Preferred  Stock,  any Person whose  beneficial  ownership of shares of
Common Stock would be  aggregated  with such  holder's  beneficial  ownership of
shares  of  Common  Stock  for  purposes  of  Section  13(d) of the 1934 Act and
Regulation 13D-G thereunder.

           "AMEX" means the American Stock Exchange, Inc.

           "Arrearage  Interest"  means interest at the rate of 12% per annum on
any dividend on shares of Series D Preferred Stock which dividend is not paid on
a Dividend  Payment Date,  whether or not declared,  from such Dividend  Payment
Date.

           "Auditors"  means Ernst & Young LLP or such other firm of independent
public accountants of recognized national standing as shall have been engaged by
the corporation to audit its financial statements.

           "Auditors'  Determination"  means a  determination  requested  by the
corporation  and  signed  by the  Auditors  concurring  with  the  corporation's
conclusion  that a requirement of the  corporation to redeem,  or a right of any
holder of shares of Series D Preferred Stock to require redemption of, shares of
Series D Preferred  Stock by reason of the  occurrence  of a specified  Optional
Redemption Event which occurs by reason of an event described in clause (1), (2)
or (3) of the  definition  of  Optional  Redemption  Event  would  result in the
corporation  being  required  to  classify  the  Series  D  Preferred  Stock  as
redeemable  preferred  stock on a balance sheet of the Corporation in accordance
with Generally Accepted Accounting Principles. The Auditors' Determination shall
(i) set forth in reasonable detail all relevant facts considered by the Auditors
in connection therewith, (ii) set forth all applicable accounting principles and
assumptions  used, and (iii) set forth in reasonable  detail or attach copies of
all legal,  expert  and other  advice or  information  used by the  Auditors  in
reaching their  conclusion.  To the extent any facts are assumed for purposes of
either the Corporation's conclusion or the Auditor's Determination, the validity



                                       3
<PAGE>

of such conclusion or  determination  shall depend upon such assumed facts being
true and complete in all material respects.

           "Blackout Period" means the period of up to 20 consecutive days after
the date the  Corporation  notifies  the holders of shares of Series D Preferred
Stock  that  they are  required  to  suspend  offers  and  sales of  Registrable
Securities  as a  result  of an  event  or  circumstance  described  in  Section
3.b.(5)(A)  of the Exchange  Agreement,  which period  commences  after the date
which is 90 days after the date of the  Closing  and  during  which  period,  by
reason of Section 3.b.(5)(B) of the Exchange  Agreement,  the Corporation is not
required to amend any  Registration  Statement or to supplement  the  Prospectus
relating to any Registration Statement;  provided, however, that such period may
be up to 30 consecutive  days if the  Corporation  so elects in accordance  with
Section  3.b.(5)(B)  of the  Exchange  Agreement,  subject  to  the  limitations
provided therein.

           "Board of Directors" or "Board" means the Board of Directors  of  the
Corporation.

           "Business Combination  Redemption Percentage" means 118% with respect
to a redemption of shares of Series D Preferred Stock in accordance with Section
8(c)(ii)(f).

           "Business Combination Redemption Price" means an amount in cash equal
to the product  obtained by  multiplying  (A) the sum of (i) $1,000 plus (ii) an
amount  equal to the  accrued  but  unpaid  dividends  on the  share of Series D
Preferred Stock to be redeemed and any Arrearage  Interest on dividends  thereon
in arrears to the date of payment of the  redemption  price  pursuant to Section
8(c)(ii)(f) times (B) the Business Combination Redemption Percentage.

           "Business Day" means (a) in the case of the Series C Preferred Stock,
any day other than a Saturday,  Sunday or other day on which commercial banks in
The City of San Francisco are authorized or required by law to remain closed and
(b) in the case of the Series D Preferred  Stock, any day other than a Saturday,
Sunday  or  other  day on  which  commercial  banks  in The City of New York are
authorized or required by law to remain closed.

           "Cash and Cash  Equivalent  Balances" of any Person on any date shall
be determined  from such Person's books  maintained in accordance with Generally
Accepted Accounting Principles,  and means, without duplication,  the sum of (1)
the cash accrued by such Person and its subsidiaries on a consolidated  basis on
such date and available for use by such Person and its subsidiaries on such date
and (2) all assets which would,  on a consolidated  balance sheet of such Person
and its  subsidiaries  prepared  as of such date in  accordance  with  Generally
Accepted Accounting Principles, be classified as cash or cash equivalents.

           "Common Stock" means the Common Stock, $0.001 par value per share, of
the  Corporation  or any shares of capital  stock into which such stock shall be
changed or reclassified after the Issuance Date.

           "Control Notice" means a Control Notice substantially in the form set
forth in Section 14(e).



                                       4
<PAGE>

           "Converted  Restriction  Amount" means on any date of determination a
number of shares of Common  Stock  equal to 4.9% of the  shares of Common  Stock
outstanding on such date.

           "Corporation  Notice" means a Corporation Notice substantially in the
form set forth in Section 14(c).

           "Dividend  Payment  Date" means each  February 1, May 1, August 1 and
November 1.

           "Exchange  Agreement"  means  the  Exchange  Agreement,  dated  as of
December  10,  1998,  by and between the  Corporation  and the several  original
holders of the Senior  Subordinated  Convertible  Notes  pursuant  to which such
Senior  Subordinated  Convertible Notes will be exchanged for shares of Series D
Preferred Stock.

           "Generally Accepted  Accounting  Principles" for any Person means the
generally  accepted  accounting  principles and practices applied by such Person
from time to time in the preparation of its audited financial statements.

           "Holder Notice" means a Holder Notice  substantially  in the form set
forth in Section 14(d).

           "Indebtedness"   as  used  in  reference  to  any  Person  means  all
indebtedness of such Person for borrowed money,  the deferred  purchase price of
property,  goods and services and obligations under leases which are required to
be capitalized in accordance with Generally Accepted  Accounting  Principles and
shall include all such  indebtedness  guaranteed in any manner by such Person or
in effect  guaranteed by such Person through a contingent  agreement to purchase
and all  indebtedness  for the  payment or  purchase  of which  such  Person has
contingently  agreed to advance or supply funds and all indebtedness  secured by
mortgage or other lien upon property owned by such Person,  although such Person
has not assumed or become liable for the payment of such indebtedness,  and, for
all purposes hereof,  such  indebtedness  shall be treated as though it has been
assumed by such Person.

           "Issuance  Date"  means (a) with  respect to the  Series C  Preferred
Stock,  the first date of original  issuance of any shares of Series C Preferred
Stock and (b) with respect to the Series D Preferred Stock, the date of original
issuance of the shares of Series D  Preferred  Stock  pursuant  to the  Exchange
Agreement.

           "Initial  Reserve  Amount"  means  6,285,000  shares of Common  Stock
reserved by the Corporation for issuance upon conversion of the shares of Series
D Preferred Stock.

           "Junior Dividend Stock" means,  collectively,  the Series A Preferred
Stock,  the Common  Stock and any other class or series of capital  stock of the
Corporation ranking junior as to dividends to the Series D Preferred Stock.

           "Junior  Liquidation  Stock"  means,   collectively,   the  Series  A
Preferred Stock, the Common Stock and any other class or series of capital stock
of the  Corporation  ranking  junior as to  liquidation  rights to the  Series D
Preferred Stock.



                                       5
<PAGE>

           "Majority  Holders" means at any time the holders of shares of Series
D Preferred Stock which shares  constitute a majority of the outstanding  shares
of Series D Preferred Stock outstanding at such time.

           "Market  Price" of any  security  on any date means the  closing  bid
price of such  security  on such  date on the  Nasdaq or such  other  securities
exchange or other  market on which such  security  is listed for  trading  which
constitutes the principal  securities  market for such security,  as reported by
Bloomberg, L.P.

           "Measurement  Period"  means with  respect to any Series D Conversion
Date,  the  period  consisting  of 12  consecutive  Trading  Days  ending on and
including the Trading Day immediately preceding such Series D Conversion Date.

           "Nasdaq" means The Nasdaq  National Market or The Nasdaq
SmallCap Market, whichever system lists the Common Stock.

           "1934 Act" means the  Securities  Exchange  Act of 1934,
as amended.

           "1933 Act" means the Securities Act of 1933, as amended.

           "NYSE" means the New York Stock Exchange, Inc.

           "Optional  Redemption  Date"  means the date which is three  Business
Days after a holder of shares of Series D  Preferred  Stock who is  entitled  to
redemption  rights under  Section  7(c)(ii)(a)  and  7(c)(ii)(b)  gives a Holder
Notice.

           "Optional Redemption Event" means  any  one  of  thefollowing events:

           1)   For any period of five consecutive Trading  Days following  the 
Issuance  Date there shall  be no reported sale price of the Common Stock on any
of the Nasdaq, the NYSE or the AMEX;

           2)   The Common Stock ceases to be listed for  trading on the Nasdaq,
the NYSE or the AMEX;

           3) Any  consolidation  or merger of the Corporation or any subsidiary
of the  Corporation  with or into another entity or other  business  combination
transaction  involving the  Corporation  or any  subsidiary  of the  Corporation
(other than a merger or  consolidation  of a subsidiary of the Corporation  into
the  Corporation  or a  wholly-owned  subsidiary of the  Corporation)  where the
stockholders of the  Corporation  immediately  prior to such  transaction do not
collectively  own at  least  51% of the  outstanding  voting  securities  of the
surviving corporation of such transaction immediately following such transaction
or the common stock of such  surviving  corporation is not listed for trading on
the Nasdaq, the NYSE or the AMEX; or the sale of all or substantially all of the
assets of the Corporation and its subsidiaries;

           4) The adoption of any amendment to the Certificate of  Incorporation
of the Corporation (other than any certificate designating a series of preferred
stock of the Corporation  which does not contravene the rights of the holders of
shares of Series D Preferred Stock) which  materially and adversely  affects the



                                       6
<PAGE>

rights of the holders of shares of Series D Preferred  Stock in respect of their
interest in the Common  Stock in a  different  and more  adverse  manner than it
affects  the rights of holders of Common  Stock  generally  or the taking of any
other action which materially and adversely affects the rights of the holders of
Series D Preferred Stock;

           5) The inability of any holder of shares of Series D Preferred  Stock
for (x) (i) 20 days (whether or not  consecutive)  or (ii) if in accordance with
Section  3.b.(5)(B) of the Exchange  Agreement the Corporation elects a Blackout
Period of up to 30 consecutive  days which commences more than 90 days after the
Issuance Date, such greater number of days as shall equal the number of days the
Blackout  Period so elected is in effect (but in no event more than 30 days), in
either  the case of such  clause  (i) or such  clause  (ii)  during  the  period
commencing  on the  Issuance  Date and  ending on the first  anniversary  of the
Issuance Date or (y) 60 days (whether or not  consecutive)  subsequent to August
29, 1997, to sell shares of Common Stock issued or issuable  upon  conversion of
shares of Series D Preferred Stock pursuant to any Registration Statement (1) by
reason of the  requirements of the 1933 Act, the 1934 Act or any of the rules or
regulations  under  either  thereof  or (2) due to such  Registration  Statement
containing any untrue statement of material fact or omitting to state a material
fact required to be stated therein or necessary to make the  statements  therein
not  misleading  or any other failure of such  Registration  Statement to comply
with the rules and regulations of the SEC; or

           6) The Corporation shall fail or default in the timely performance of
any material  obligation to a holder of shares of Series D Preferred Stock under
the terms of this Amended and Restated Certificate of Incorporation or under the
Exchange Agreement or any other agreement or document entered into in connection
with the issuance of shares of Series D Preferred  Stock, as such agreements and
instruments may be amended from time to time.

           "Optional Redemption Percentage" means 118%.

           "Optional  Redemption  Price"  means an amount  in cash  equal to the
product  obtained by  multiplying  (a) the sum of (i) $1,000 plus (ii) an amount
equal to the  accrued  but unpaid  dividends  on the share of Series D Preferred
Stock to be redeemed and any Arrearage  Interest on dividends thereon in arrears
to the applicable  Optional  Redemption  Date times (b) the Optional  Redemption
Percentage.

           "Parity   Dividend   Stock"   means   any  class  or  series  or  the
Corporation's  capital  stock  ranking,  as to  dividends,  on a parity with the
Series D Preferred Stock.

           "Parity   Liquidation  Stock"  means  any  class  or  series  of  the
Corporation's  capital stock ranking, as to liquidation rights, on a parity with
the Series D Preferred Stock.

           "Permitted  Indebtedness" means (i) Indebtedness which is outstanding
and which would be reflected  on a balance  sheet of the  Corporation  as of the
Issuance  Date  prepared  in  accordance  with  Generally  Accepted   Accounting
Principles  and (ii)  Indebtedness  incurred to finance (A) inventory or (B) the
lease or  purchase of  equipment  (which  Indebtedness  shall be secured by such
equipment) used in the Corporation's  business,  the outstanding  amount thereof
which does not exceed $10,000,000 during the first year after the Issuance Date,



                                       7
<PAGE>

$15,000,000  during the  second  year after the  Issuance  Date and  $30,000,000
during the third year after the Issuance Date.

           "Person"  means  an  individual,  partnership,  corporation,  limited
liability company, trust, incorporated organization, unincorporated association,
joint stock company, government, governmental agency or political subdivision.

           "Redemption Date" means December 30, 1998.

           "Redemption  Notice" means a Redemption  Notice  substantially in the
form set forth in Section 14(b).

           "Redemption  Price"  means an  amount  in cash  equal to the  product
obtained by  multiplying  (i) the sum of (A) $1,000 plus (B) an amount  equal to
the accrued but unpaid dividends on such share of Series D Preferred Stock to be
redeemed and any Arrearage  Interest on dividends thereon in arrears to the date
of payment of the Redemption Price times (ii) 130%.

           "Registrable  Securities"  means the shares of Common Stock  issuable
upon  conversion of shares of Series D Preferred  Stock and the shares of Common
Stock  issuable as dividends on the Series D Preferred  Stock,  and any stock or
other  securities  into which or for which the  Common  Stock may  hereafter  be
changed, converted or exchanged by the Corporation or its successor, as the case
may be, and any other securities issued to holders of such Common Stock (or such
shares  into  which or for  which  such  shares  are so  changed,  converted  or
exchanged) upon any  reclassification,  share  combination,  share  subdivision,
share dividend, merger, consolidation or similar transaction or event.

           "Registration  Statement"  shall  have  the  meaning provided  in the
Exchange Agreement.

           "SEC" means the United  States  Securities  and Exchange  Commission.

           "Senior  Dividend  Stock"  means the Series C Preferred  Stock of the
Corporation  and any other class or series of capital  stock of the  Corporation
ranking senior as to dividends to the Series D Preferred Stock.

           "Senior  Liquidation Stock" means the Series C Preferred Stock of the
Corporation  and any other class or series of capital  stock of the  Corporation
ranking senior as to liquidation rights to the Series D Preferred Stock.

           "Series  C  Conversion   Agent"  means   Boston   EquiServe   Limited
Partnership,  as Servicing  Agent for  BankBoston,  N.A., or its duly  appointed
successor  who shall be serving as transfer  agent and  registrar for the Common
Stock and who shall have been authorized by the Corporation to act as conversion
agent for the Series C Preferred Stock.

           "Series C  Conversion  Date"  means (1) the date on which a notice of
conversion  of Series C  Preferred  Stock is  actually  received by the Series C
Conversion Agent,  whether by mail,  courier,  personal service,  telephone line
facsimile  transmission  or other means,  in case of a  conversion  of shares of
Series  C  Preferred  Stock  pursuant  to  Section  8(b)(i);  or (2) the  fourth



                                       8
<PAGE>

anniversary  of the  Issuance  Date,  in the case of a  conversion  of shares of
Series C Preferred Stock pursuant to Section 8(b)(ii).

           "Series  C  Conversion  Price"  means an  amount  equal to 85% of the
average  Closing Price of the Common Stock for the ten Trading Day period ending
three Trading Days prior to the Series C Conversion Date.

           "Series D  Conversion  Agent"  means  BankBoston,  N.A.,  or its duly
appointed  successor,  who shall  serve as  conversion  agent  for the  Series D
Preferred Stock.

           "Series  D  Conversion  Date"  means  the  date on  which a  Series D
Conversion Notice is actually received by the Series D Conversion Agent, whether
by mail,  courier,  personal service,  telephone line facsimile  transmission or
other  means,  in case of a  conversion  of shares of Series D  Preferred  Stock
pursuant to Section 8(c)(i).

           "Series D Conversion Notice" means a Notice of Conversion of Series D
Convertible  Preferred  Stock  substantially  in the form set  forth in  Section
14(a).

           "Series D Conversion  Price" means the lesser of (a) $1.125 per share
(subject  to  equitable  adjustments  from  time  to time  on  terms  reasonably
acceptable to the Majority  Holders for (i) stock splits,  (ii) stock dividends,
(iii) combinations, (iv) capital reorganizations, (v) issuance to all holders of
Common  Stock of rights or  warrants to purchase  shares of Common  Stock,  (vi)
distribution  by the  Corporation to all holders of Common Stock of evidences of
indebtedness  of the  Corporation  or cash (other than  regular  quarterly  cash
dividends),  (vii) Tender Offers by the  Corporation or any  Subsidiary  for, or
other repurchases of shares of, Common Stock in one or more transactions  which,
individually or in the aggregate, result in the purchase of more than 10% of the
Common  Stock  outstanding,  and (viii)  similar  events  relating to the Common
Stock,  in each case which occur,  or with respect to which "ex-" trading of the
Common  Stock  begins,  on or after  December  9,  1998,  and on or  before  the
applicable  Series D Conversion  Date) and (b) on any Series D Conversion  Date,
90% of the lowest per share  Trading  Price  during the  applicable  Measurement
Period for such Series D Conversion  Date in a trade in which neither the Holder
nor any of its Affiliates  was the seller,  subject to adjustment in the case of
such clause (a) and clause (b) in accordance with Section 7(c).

           "Series D Preferred  Stock" means the Series D Convertible  Preferred
Stock of the Corporation.

           "Stockholder  Approval"  shall have  the  meaning  provided  in   the
Exchange Agreement.

           "Tender Offer" means a tender offer or exchange offer.

           "Trading Day" means a day on whichever of (x) the national securities
exchange,  (y) Nasdaq or (z) such  other  securities  market,  which at the time
constitutes  the  principal  securities  market for the Common Stock is open for
general trading of securities.

           "Trading Price" on any date means the lowest sale price (regular way)
for one share of the Common Stock on such date,  on the first  applicable  among
the  following:  (a) the  national  securities  exchange  on which the shares of



                                       9
<PAGE>

Common Stock are listed which  constitutes the principal  securities  market for
the  Common  Stock,  (b)  Nasdaq,  or (c) such  other  securities  market  which
constitutes  the principal  securities  market for the Common Stock, in any such
case as reported by  Bloomberg,  L.P. or if no such sale prices are so reported,
then the  representative  bid price of the Common Stock as quoted by a broker or
dealer  which  is a  member  firm of the NASD (in  each  such  case  subject  to
equitable  adjustment  from time to time on terms  reasonably  acceptable to the
Majority Holders for (i) stock splits, (ii) stock dividends, (iii) combinations,
(iv)  capital  reorganizations,  (v)  issuance to all holders of Common Stock of
rights or warrants to purchase  shares of Common Stock at a price per share less
than  the  Trading  Price  which  would   otherwise  be  applicable,   (vi)  the
distribution  by the  Corporation to all holders of Common Stock of evidences of
indebtedness  of the  Corporation  or cash (other than  regular  quarterly  cash
dividends),  (vii) Tender  Offers by the  Corporation  or any  subsidiary of the
Corporation  or other  repurchases  of  shares  of  Common  Stock in one or more
transactions which, individually or in the aggregate,  result in the purchase of
more  than 10% of the  Common  Stock  outstanding,  and  (viii)  similar  events
relating  to the Common  Stock,  in each such case  which  occur on or after the
Issuance Date); provided,  however, that if on any Trading Day there shall be no
reported sale price (regular way) of such security,  the "Trading Price" on such
Trading Day shall be the lowest sale price (regular way) of such security on the
Trading Day next  preceding such Trading Day on which a sale price (regular way)
for such security has been so reported.

           2.  Rank.   The shares of Series C Preferred  Stock shall rank senior
to the Series D Preferred  Stock, and both  the Series C Preferred Stock and the
Series D Preferred Stock shall rank senior to the Series A Preferred  Stock  and
the  Common  Stock  and any  shares of any other series  of  Preferred  Stock or
any  shares  of any  other class of preferred stock of the  Corporation,  now or
hereafter issued, as to payment of  dividends  and  distribution  of assets upon
liquidation, dissolution, or winding up of the Corporation, whether voluntary or
involuntary.  However,  the  relative  rank of the Series D  Preferred Stock to 
future  issuances may be altered  by written  consent of the Majority Holders in
advance of such issuance.

           3.  Dividend Rights.

               a.  Series A Preferred Stock.  Subject to the rights of series of
Preferred Stock which may from time to time come into  existence,  the  holders
of  the  Series A  Preferred Stock shall be entitled to receive,  when  and  as 
declared by the Board of Directors, out of any assets of the corporation legally
available therefor, such  dividends as may be declared  from time to time by the
Board of Directors.   The Board of  Directors  shall not pay any dividend to the
holders of the Common Stock unless and until it has paid an equivalent dividend,
on a pro rata per share basis, to the holders of the Series A Preferred Stock.

               b.  Series C Preferred  Stock.  The holders of shares of Series C
Preferred Stock shall be  entitled  to receive,  when,  as, and if  declared  by
the  Board  of  Directors  out of funds  legally  available  for such  purpose, 
dividends  paid semi-annually on May 31 and November 30 of each year to the 
holders of record of such  shares  on  March  31 and  September 30 of such  year
as  follows:  (i)  a  stock-on-stock  dividend  of $10.00 per  annum,  paid in  
arrears,  in shares of  Common Stock (valued at 85% of the average closing price
of the Common Stock for the ten Trading Day  period  ending three Trading Days 
prior to the date on which  the  dividend  is  paid);  plus  (ii) a cash  amount
equaling  0.00005%  of the Company's  United  States net sales,  if any, for the



                                       10
<PAGE>

preceding two  calendar quarters of its SP-303/Provir  product for the treatment
of diarrhea less $5.00  (the value of the semi-annual stock dividend). Dividends
on the shares of Series C Preferred  Stock shall be  cumulative.   If under  
Delaware law, the Company is unable  to pay the cash  amount  of the  dividends,
then  this  portion  of the  dividends  shall be  payable  in shares of Common  
Stock  (valued  at 85% of the average  closing price of the Common Stock for the
ten Trading Day period ending three Trading Days prior to the date on which the 
dividend is paid).

                c.  Series D Preferred Stock

                    (i) The  holders  of  shares  of  Series D  Preferred  Stock
shall be entitled to receive,  when,  as, and if  declared  by  the  Board  of  
Directors out of funds legally available for such purpose, dividends at the rate
of $55 per annum per share, and no more (except as otherwise provided herein),
which shall be fully  cumulative,  shall accrue without interest (except as
otherwise  provided  herein as to  dividends  in arrears)  from the date of
original  issuance of each share of Series D  Preferred  Stock and shall be
payable  quarterly on each  Dividend  Payment Date of each year  commencing
February 1, 1999 (except that if any such date is not a Business  Day, then such
dividend  shall  be  payable  on the  next  succeeding  day that is a Business
Day) to holders of record as they appear on the stock books of the  Corporation 
on such record dates, not more than ten nor less than five days preceding  the 
payment  dates  for  such  dividends,  as  shall  be fixed  by  the  Board.   
Notwithstanding any other provision hereof, the rate of dividends on the shares 
of Series D  Preferred  Stock  shall be subject to  increase  in accordance with
Section 7(c)(ii)(b)(iv).

           Dividends  on the Series D Preferred  Stock shall be paid in cash or,
subject to the  limitations in Section  3(c)(ii),  shares of Common Stock or any
combination of cash and shares of Common Stock, at the option of the Corporation
as hereinafter provided. The amount of the dividends payable per share of Series
D  Preferred  Stock for each  quarterly  dividend  period  shall be  computed by
dividing the annual dividend amount by four. The amount of dividends payable for
the  initial  dividend  period  and any  period  shorter  than a full  quarterly
dividend  period  shall be  computed  on the basis of a  360-day  year of twelve
30-day  months.  Dividends not paid on a Dividend  Payment Date,  whether or not
such dividends have been declared,  will bear Arrearage  Interest until paid. No
dividends or other distributions,  other than dividends payable solely in shares
of any  Junior  Dividend  Stock,  shall be paid or set apart for  payment on any
shares  of  Junior  Dividend  Stock,  and  no  purchase,  redemption,  or  other
acquisition  shall be made by the  Corporation of any shares of Junior  Dividend
Stock  unless  and  until all  accrued  and  unpaid  dividends  on the  Series D
Preferred  Stock and  Arrearage  Interest  on  dividends  in arrears at the rate
specified herein shall have been paid or declared and set apart for payment.

           If at any time any dividend on any Senior  Dividend Stock shall be in
default,  in whole or in part,  no dividend  shall be paid or  declared  and set
apart for payment on the Series D Preferred  Stock  unless and until all accrued
and unpaid  dividends with respect to the Senior Dividend  Stock,  including the
full  dividends for the then current  dividend  period,  shall have been paid or
declared and set apart for payment, without interest. No full dividends shall be
paid or declared and set apart for payment on any Parity  Dividend Stock for any
period  unless all  accrued  but unpaid  dividends  (and  Arrearage  Interest on
dividends in arrears) have been, or contemporaneously  are, paid or declared and
set apart for such payment on the Series D Preferred  Stock.  No full  dividends
shall be paid or  declared  and set apart for  payment on the Series D Preferred



                                       11
<PAGE>

Stock for any period  unless all  accrued  but unpaid  dividends  have been,  or
contemporaneously  are, paid or declared and set apart for payment on the Parity
Dividend Stock for all dividend  periods  terminating on or prior to the date of
payment of such full  dividends.  When  dividends  are not paid in full upon the
Series D Preferred Stock and the Parity  Dividend  Stock,  all dividends paid or
declared and set apart for payment upon shares of Series D Preferred  Stock (and
Arrearage  Interest on dividends in arrears) and the Parity Dividend Stock shall
be paid or declared  and set apart for  payment pro rata,  so that the amount of
dividends  paid or declared  and set apart for payment per share on the Series D
Preferred  Stock and the Parity  Dividend  Stock shall in all cases bear to each
other the same ratio that accrued and unpaid  dividends  per share on the shares
of Series D Preferred Stock and the Parity Dividend Stock bear to each other.

           Any references to "distribution" contained in this Section 3(c) shall
not be deemed to include any stock dividend or distributions  made in connection
with any liquidation,  dissolution,  or winding up of the  Corporation,  whether
voluntary or involuntary.

                    (ii) If the  Corporation  elects in the exercise of its sole
discretion   to  issue  shares  of  Common  Stock in payment of dividends on the
Series D  Preferred  Stock  with  respect  to any  Dividend  Payment  Date,  the
Corporation shall (1) give notice to the holders of the Series D Preferred Stock
at  least  14  days  prior  to  the  applicable  Dividend  Payment  Date  of the
Corporation's  election to exercise  such right and (2) deliver,  or cause to be
delivered,  by the third  Trading Day after such  Dividend  Payment Date to each
holder of such shares the number of whole shares of Common  Stock  arrived at by
dividing  the  per  share  Series  D  Conversion  Price  (determined  as if  the
applicable Dividend Payment Date were a Series D Conversion Date) of such shares
of Common  Stock into the total  amount of cash  dividends  such holder would be
entitled to receive if the aggregate  dividends on the Series D Preferred  Stock
held by such  holder  which are being paid in shares of Common  Stock were being
paid in cash;  provided,  however,  that if  shares  of  Common  Stock  for such
dividend are not delivered to holders of Series D Preferred Stock on or prior to
the third Trading Day after a Dividend Payment Date, then the Corporation  shall
not be  entitled  to pay such  dividend  in  shares  of  Common  Stock  and such
dividend,  together with Arrearage Interest from the applicable Dividend Payment
Date,  shall be payable  solely in cash.  No  fractional  shares of Common Stock
shall be issued in payment of dividends.  In lieu thereof, the Corporation shall
pay cash in an  amount  equal to the  product  of (x) the  Trading  Price of the
Common Stock for the 12  consecutive  Trading Days ending on and  including  the
Trading Day  immediately  preceding  such  Dividend  Payment  Date times (y) the
fraction of a share of Common  Stock which  would  otherwise  be issuable by the
Corporation.  The  Corporation  shall not  exercise its right to issue shares of
Common Stock in payment of dividends on Series D Preferred Stock if:

                         (A) the  number of shares of Common  Stock at the  time
authorized,  unissued and unreserved for all purposes,  together with the number
of shares of Common Stock held in the Corporation's treasury, is insufficient to
pay the portion of such dividends to be paid in shares of Common Stock;



                                       12
<PAGE>

                         (B) the  issuance or delivery of shares of Common Stock
as a  dividend  payment  would  require  registration  with or  approval  of any
governmental  authority  under any law or regulation,  and such  registration or
approval has not been effected or obtained;

                         (C) the shares  of Common Stock  to  be  issued   as  a
dividend payment have not  been  authorized  for listing, upon  official  notice
of issuance,  on any securities  exchange or market on which the Common Stock is
then  listed;  or have not been  approved  for  quotation if the Common Stock is
traded in the over-the-counter market;

                          (D) the  Series  D  Conversion  Price  (determined as 
if the applicable Dividend Payment Date were a Series D Conversion Date) is less
than the par value of one share of Common Stock;

                          (E)  the shares of Common  Stock t o be issued  as  a
dividend (1) cannot  be  sold or  transferred without restriction by holders  of
shares of Series D Preferred Stock  who receive such shares of Common Stock as a
dividend  payment and who are not  Affiliates of the  Corporation or (2) are  no
longer listed on the NYSE, the AMEX  or the Nasdaq; 

                          (F) the issuance of shares of Common  Stock in payment
of dividends  on Series  D Preferred Stock  held  by  any  holder of  shares  of
Series D Preferred Stock  would  result in such holder (including all Aggregated
Persons of such holder) beneficially owning more than 4.9% of the Common  Stock,
determined  as provided in the proviso to the second sentence of Section  8(c)
(i)(a) or would result in the issuance to such holder (including all  Aggregated
Persons of such holder) of an  aggregate  number of shares of Common Stock upon
conversion of shares of Series D Preferred Stock or in payment of dividends on
shares of Series D Preferred Stock in excess of the 4.9% limitation provided  in
Section 8(c)(i)(b); 

                          (G) an Optional Redemption Event shall  have  occurred
and on the  applicable  Dividend  Payment Date any holder of shares of  Series D
Preferred  Stock  shall be  entitled  to exercise  optional redemption  rights  
under  Section  7(c)(ii)  hereof by reason of such  Optional Redemption Event or
shall  have  exercised  such  optional  redemption  rights and  the  Corporation
shall not have paid the applicable Optional Redemption Price.

           Shares of Common  Stock  issued in payment of  dividends  on Series D
Preferred Stock pursuant to this Section shall be, and for all purposes shall be
deemed to be,  validly  issued,  fully paid and  nonassessable  shares of Common
Stock  of  the  Corporation;   the  issuance  and  delivery  thereof  is  hereby
authorized; and the dispatch in full thereof will be, and for all purposes shall
be deemed to be,  payment in full of the  cumulative  dividends to which holders
are entitled on the applicable Dividend Payment Date.

                    (iii)  Neither the Corporation  nor any subsidiary  of  the
Corporation  shall  (1) make   any  Tender  Offer for  outstanding  shares    of
Common Stock, unless the Corporation contemporaneously therewith makes an offer,
or (2) enter into an agreement  regarding a Tender Offer for outstanding  shares
of Common Stock by any Person other than the  Corporation  or any  subsidiary of
the  Corporation,  unless such Person  agrees  with the  Corporation  to make an
offer,  in either  such case to each  holder of  outstanding  shares of Series D



                                       13
<PAGE>

Preferred  Stock to  purchase  for cash at the time of  purchase  in such Tender
Offer the same  percentage  of shares of Series D  Preferred  Stock held by such
holder as the  percentage  of  outstanding  shares of Common Stock offered to be
purchased in such Tender Offer at a price per share of Series D Preferred  Stock
equal to the greater of (i) the quotient obtained by dividing (a) the sum of (1)
$1,000  plus (2) an amount  equal to the accrued  but unpaid  dividends  on such
share of  Series D  Preferred  Stock and any  Arrearage  Interest  on  dividends
thereon in arrears to the date of purchase pursuant to this Section 3(c)(iii) by
(b) 0.9 and (ii) an amount equal to the product  obtained by multiplying (x) the
number of shares of Common Stock which would,  but for the purchase  pursuant to
such Tender Offer,  be issuable on conversion in accordance with Section 9(a) of
one share of Series D Preferred Stock if a Series D Conversion Notice were given
by the holder of such share of Series D Preferred  Stock on the date of purchase
pursuant to such Tender Offer  (determined  without  regard to any limitation on
beneficial  ownership  contained in the second sentence of Section 8(c)(i)(a) or
in Section  8(c)(i)(b)  times (y) the price per share of Common Stock offered in
such Tender Offer.

           4. Series D Preferred Stock Capital. The amount to be represented in 
the capital  account for  the Series D Preferred Stock  at  all times  for  each
outstanding  share of Series D Preferred Stock shall be an amount at least equal
to the sum of (1) $1,000 plus (2) to the extent that the corporation has surplus
in its capital  account,  an amount equal to the accrued but unpaid dividends on
such share of Series D Preferred  Stock and any Arrearage  Interest on dividends
thereon in arrears to the date of determination  plus (3) to the extent that the
corporation has surplus in its capital  account,  an amount equal to the product
obtained by  multiplying  (a) the sum of (1) $1,000 plus (2) an amount  equal to
the accrued but unpaid  dividends on such share of Series D Preferred  Stock and
any  Arrearage  Interest  on  dividends  thereon  in  arrears  to  the  date  of
determination  times (b) 18%. Upon  original  issuance of each share of Series D
Preferred  Stock,  an amount  equal to $1,000  shall be credited to the Series D
Preferred Stock capital  account of the  corporation  and, to the extent at such
time the corporation has surplus in its capital account,  an amount equal to the
amount  specified  in the  preceding  clause  (3) (or so much  thereof  as is in
surplus)  shall be  transferred  from  surplus to the Series D  Preferred  Stock
capital  account.  If at any time the  corporation  shall have  credited  to the
Series D Preferred  Stock capital  account less than the full amount required by
the preceding  clauses (1) through (3), then (x) if at any time  thereafter  the
corporation  has surplus in its capital  account,  the  corporation  immediately
shall transfer  surplus to the Series D Preferred  Stock capital  account to the
extent  available  and  necessary to satisfy the  requirements  of the preceding
clauses (1) through (3), (y)  notwithstanding  the particular shares of Series D
Preferred  Stock in  respect of which an amount in excess of $1,000 per share of
Series D Preferred  Stock shall have been  transferred to the Series D Preferred
Stock capital account, any amount in excess of $1,000 for each outstanding share
of Series D Preferred Stock shall be treated as Series D Preferred Stock capital
pro rata for all outstanding shares of Series D Preferred Stock and (z) upon any
conversion of a share of Series D Preferred Stock, an amount equal to $0.001 per
share of common  stock  issued  upon such  conversion  shall be  credited to the
common  stock  capital  account and the balance in the Series D Preferred  Stock
capital  account in respect of such converted  share of Series D Preferred Stock
shall be retained in the Series D Preferred Stock capital account, to the extent
required  under the preceding  clauses (1) through (3).  Nothing in this Section
shall require the  corporation  in a balance sheet  prepared in accordance  with
generally accepted  accounting  principles to reflect more than $1,000 per share
in Series D Preferred  Stock capital for purposes of such balance sheet, if such
presentation  would not be in  accordance  with  generally  accepted  accounting



                                       14
<PAGE>

principles,  so long as the  notes  to any  such  balance  sheet  make  adequate
disclosure of the  requirements of this Section and the capital  accounts of the
corporation  for  purposes  of the  general  corporation  law of  the  state  of
Delaware.
           
          5.  Liquidation Preference.

               a. In the event of a liquidation, dissolution, or winding up of 
the  Corporation,  whether voluntary or involuntary, the  holders  of Series   C
Preferred  Stock shall be entitled to receive,  prior and in  preference  to any
distribution  to the  holders  of the  Series D  Preferred  Stock,  the Series A
Preferred  Stock,  and the Common Stock,  out of the assets of the  Corporation,
whether  such assets  constitute  stated  capital or surplus of any  nature,  an
amount per share of Series C Preferred  Stock equal to $100.00  plus any accrued
and  unpaid  dividends  and no  more.  In  the  event  that  the  assets  of the
Corporation are insufficient to make the foregoing distribution, then the entire
assets  of the  Corporation  available  for  distribution  shall be  distributed
ratably  among the  holders  of the  Series C  Preferred  Stock and any stock on
parity with the Series C Preferred  Stock with respect to liquidation  rights in
proportion to the respective preferential amounts to which each is entitled (but
only to the extent of such preferential  amounts).  After payment in full of the
liquidation  price of the shares of the Series C Preferred Stock with respect to
liquidation  rights,  the  holders of such  shares  shall not be entitled to any
further participation in any distribution of the assets by the Corporation.

               b. Upon the completion of the  distribution  required by Section 
5(a) above, if  any assets  remain  in  the  Corporation,  the holders of Series
D Preferred  Stock shall be entitled to receive out of such remaining  assets of
the Corporation, whether such assets constitute stated capital or surplus of any
nature, an amount per share of Series D Preferred Stock equal to the Liquidation
Preference (as defined  above) and no more,  before any payment shall be made or
any assets  distributed  to the holders of Junior  Liquidation  Stock,  provided
however,  that such  rights  shall  accrue to the  holders of Series D Preferred
Stock  only in the event that the  Corporation's  payments  with  respect to the
liquidation preference of the holders of Senior Liquidation are fully met. After
the liquidation  preferences of the Senior  Liquidation Stock are fully met, the
entire assets of the Corporation available for distribution shall be distributed
ratably  among the  holders  of the  Series D  Preferred  Stock  and any  Parity
Liquidation Stock in proportion to the respective  preferential amounts to which
each is entitled (but only to the extent of such  preferential  amounts).  After
payment in full of the liquidation price of the shares of the Series D Preferred
Stock and the Parity  Liquidation Stock, the holders of such shares shall not be
entitled  to any  further  participation  in any  distribution  of assets by the
Corporation. In the event that the assets of the Corporation are insufficient to
make the  foregoing  distribution,  then the  entire  assets of the  Corporation
available for distribution shall be distributed ratably among the holders of the
Series D  Preferred  Stock and any stock on parity  with the Series D  Preferred
Stock with respect to  liquidation  rights  in  proportion  to   the  respective
preferential  amounts to which each is entitled  (but only to the extent of such
preferential  amounts).  With respect to the Series D Preferred Stock, neither a
consolidation or merger of the Corporation  with another  corporation nor a sale
or transfer of all or part of the Corporation's assets for cash, securities,  or
other property in and of itself will be considered a  liquidation,  dissolution,
or winding up of the Corporation.




                                       15
<PAGE>

               c. After  payment in full of the liquidation  price as set  forth
above in Sections 5(a) and 5(b) above, if assets remain in the corporation,  the
holders of Series A Preferred  Stock shall be entitled to receive,  prior and in
preference  to any  distribution  of any of the assets or  surplus  funds of the
Corporation  to the  holders  of the Common  Stock by reason of their  ownership
thereof,  the  amount of  $8.147  (the  "Original  Issue  Price")  per share (as
adjusted for any stock  dividends,  combinations  or splits with respect to such
shares) plus all accrued or declared but unpaid dividends on such share for each
share  of  Series  A  Preferred  Stock  then  held by such  holder.  If upon the
occurrence  of such  event,  the  assets and funds  thus  distributed  among the
holders of the Series A  Preferred  Stock  shall be  insufficient  to permit the
payment to such  holders of the full  aforesaid  preferential  amount,  then the
entire assets and funds of the Corporation  legally  available for  distribution
shall be distributed  ratably among the holders of the Series A Preferred  Stock
in proportion to the preferential  amount each such holder is otherwise entitled
to receive.  

               d. After payment to the holders of the Series C Preferred  Stock,
Series D Preferred  Stock, and Series A Preferred Stock of the amounts set forth
in Sections 5(a), (b), and (c), respectively, above, the entire remaining assets
and funds of the Corporation  legally available for distribution,  if any, shall
be distributed  among the holders of the Common Stock and the Series A Preferred
Stock in  proportion  to the  shares of Common  Stock  then held by them and the
shares of Common Stock which they then have the right to acquire upon conversion
of the  shares of Series A  Preferred  Stock then held by them.  The  holders of
Series C Preferred  Stock and Series D Preferred  Stock shall not be entitled to
any further  participation  in any  distribution  of assets by the  Corporation,
other than payment as set forth in Section 5(a) and 5(b), respectively.  

               e. With  respect to the  Series A  Preferred  Stock and Series C 
Preferred Stock,  (i) any  acquisition of the Corporation by means of merger or 
other form  of corporate  reorganization  in  which  outstanding  shares  of the
Corporation  are exchanged  for  securities or other  consideration  issued,  or
caused to be issued, by the acquiring  corporation or its subsidiary (other than
a mere  reincorporation  transaction) or (ii) a sale of all or substantially all
of the assets of the Corporation, shall be treated as a liquidation, dissolution
or winding  up of the  Corporation  and shall  entitle  the  holders of Series C
Preferred  Stock and Series A Preferred  Stock to receive at the closing thereof
the amount as specified in Section 5(a) and Section 5(c), respectively.

               f. With  respect to the holders of Series A  Preferred  Stock and
Series C Preferred Stock,  whenever the distribution provided for the holders of
the Series A Preferred Stock in this Section 5 shall be payable in securities or
property  other than cash, the value of such  distribution  shall be as follows:

                    (i)  Securities  not subject to  investment  letter or other
similar restrictions on free marketability:




                                       16
<PAGE>

                         (A) If traded on a securities exchange, the value shall
be deemed to be the  average  of the  closing  prices of the securities  on such
exchange  over the 30-day period ending  three (3) days prior to the closing;

                   
                         (B) If  actively  traded  over-the-counter,  the  value
shall be deemed to be the average of the closing bid or sale prices  (whichever
are applicable)  over  the 30-day  period  ending three (3) days prior  to  the 
closing; and
                    
                         (C) If there is no  active  public  market,  the  value
shall be the fair market value  thereof,  as  determined  in good faith by the
Board of Directors of the Corporation.

                     (ii) The method  of  valuation  of  securities  subject to 
investment letter  or other restrictions on  free  marketability  (other    than
restrictions  arising solely by virtue of a stockholder's status as an affiliate
or former  affiliate)  shall be to make an appropriate  discount from the market
value determined as above in (i) (A), (B) or (C) to reflect the approximate fair
market value  thereof,  as determined in good faith by the Board of Directors of
the Corporation.

                     (iii) In the event of any bona-fide  dispute  between the 
Corporation  and one or more  holders of the  Series A  Preferred  Stock as   to
any fair market value  determination  under clauses  (i)(C) or (ii) above,  such
dispute shall be resolved  through  binding  arbitration  under the rules of the
American  Arbitration  Association,  with the  arbitration  panel  consisting of
persons  familiar  with the  valuation  of public and private  entities and such
panel being  advised,  as to such  valuation  issues,  by an investment  bank of
nationally   recognized  standing,   the  costs  thereof  to  be  borne  by  the
non-prevailing party.

           6.  No Sinking Fund.  The shares of Series D Preferred  Stock  shall
not be entitled to the benefits of  any  sinking  fund for the  redemption  or  
repurchase  of  shares  of  Series D Preferred Stock.

           7.  Redemption.

               (a) Series A Preferred  Stock.   The  Series  A Preferred Stock 
is not redeemable.

               (b) Series C  Preferred   Stock.   The  Series  C Preferred Stock
is not redeemable.

               (c) Series D Preferred  Stock.   The  Series  D Preferred   Stock
is   subject   to  the   following   redemption provisions:

                   (i)  Redemption at Option of Corporation.

                        (A) Optional Redemption.

                            (1) So  long as (x) the  Corporation  shall  be in  
compliance  in  all  material  respects  with its obligations  to the holders of
the Series D Preferred Stock  (including,  without  limitation,  its obligations



                                       17
<PAGE>

under the  Exchange  Agreement  and this  Amended and  Restated  Certificate  of
Incorporation)  and (y) on the date the Corporation  gives the Redemption Notice
and on the  Redemption  Date,  the  Corporation  has Cash  and  Cash  Equivalent
Balances (excluding  investment  securities) which are sufficient,  after taking
into account the Corporation's cash requirements during the period from the date
the  Redemption  Notice is given to the  Redemption  Date, to pay the Redemption
Price of the shares of Series D Preferred Stock to be redeemed,  the Corporation
shall  have the right to  redeem  all or any part of the  outstanding  shares of
Series D Preferred  Stock pursuant to this Section  7(c)(i)(A) at the Redemption
Price.  In order to exercise its right of redemption  under this Section 7(c)(i)
(A), the Corporation  shall give a Redemption Notice to the holders of shares of
Series D  Preferred  Stock not less  than 20 or more  than 30 days  prior to the
Redemption Date.

                            (2)  On  the Redemption   Date (or such  later  date
as  a  holder  of  shares  of Series D Preferred  Stock shall  surrender  to the
Corporation  the  certificate(s)  for the  shares  of Series D  Preferred  Stock
redeemed),  the  Corporation  shall pay to or upon the  order of each  holder of
shares of Series D Preferred  Stock by wire  transfer of  immediately  available
funds to such account as shall be  specified  for such purpose by such holder in
an amount equal to the Redemption Price of all of such holder's shares of Series
D Preferred Stock to be redeemed. A holder of shares of Series D Preferred Stock
which are redeemed pursuant to this Section 7(c) (i)(A) shall not be entitled to
payment of the Redemption Price of such shares of Series D Preferred Stock until
such holder shall have surrendered the  certificate(s) for such shares of Series
D  Preferred  Stock to the  Corporation  or, in the case of the  loss,  theft or
destruction of any such certificate,  given indemnity in accordance with Section
13. If the Corporation  shall fail to pay the Redemption  Price of any shares of
Series D Preferred  Stock in full when due,  then the amount  thereof shall bear
interest to the extent not  prohibited by applicable  law at the rate of 12% per
annum from the due date thereof until paid in full.

                            (3)  Notwithstanding  the   giving of a   Redemption
Notice,  each holder of shares of Series D Preferred Stock shall be entitled  to
convert in  accordance with  Section 8(c) any shares of Series D Preferred Stock
which are to be redeemed at any time prior to (1) the Redemption Date or (2) if 
the Corporation fails to pay the Redemption Price in full to such holder  on the
Redemption  Date,  the date on which  the  Corporation pays the Redemption Price
in full to such holder for all shares of Series D Preferred Stock to be redeemed
rom such holder.

                            (4) Any redemption of shares of Series D Preferred
Stock  pursuant  to this  Section  7(c)(i)(A)  shall  be  made  as  nearly   as
practical  pro rata from all  holders  of shares  of  Series D  Preferred  Stock
outstanding,  subject to reduction of the shares of Series D Preferred  Stock to
be  redeemed  from any  holder by reason  of  conversions  of shares of Series D
Preferred  Stock of such holder between the date the Redemption  Notice is given
and the Redemption Date.

                            (5)  Upon receipt by the Corporation  from a holder 
of shares of Series D Preferred Stock of certificates for shares of Series D 
Preferred Stock  evidencing a greater number of shares of  Series D  Preferred  
Stock than the number of shares of Series D Preferred  Stock to be redeemed in  
accordance  with this Section  7(c)(i)(A),  the Corporation shall,  within three
Trading Days after such surrender,  issue and deliver to or  upon the order of 



                                       18
<PAGE>

such  holder a new certificate  for the  balance of shares of Series D Preferred
Stock, if any.

                        (B)  No  Other  Redemption  at  the  Option  of the 
Corporation.  Except as otherwise  specifically provided in Section 7(a), the
Corporation  shall  not have  any  right  to  redeem  any  shares of Series D
Preferred Stock at the option of the Corporation.

                   (ii) Redemption  Upon an Optional  Redemption  Event.

                        (a)  Redemption  Right  Upon Optional Redemption  Event.
If an Optional  Redemption Event occurs,  then each holder of shares of Series D
Preferred  Stock  shall  have the  right,  at such  holder's option,  to require
the  Corporation  to redeem all of such  holder's  shares of Series D  Preferred
Stock,  or any portion  thereof,  on the date that is three Business  Days after
the date of the Holder  Notice  given with  respect to such Optional  Redemption
Event.  Each holder of shares of Series D Preferred  Stock shall  have the right
to require the Corporation to redeem  all or any such portion  of such  holder's
shares of Series D  Preferred  Stock if an  Optional Redemption  Event occurs at
any time while any of such holder's shares of Series D  Preferred  Stock  are  
outstanding  at a price per share of Series D Preferred Stock equal to the 
Optional Redemption Price.

                        (b) Notices;  Method  of  Exercising Optional Redemption
Rights, Etc.

                            (i)  On or before the fifth Business Day  after the
occurrence of an Optional Redemption Event, the Corporation  shall  give to each
holder  of  outstanding  shares  of  Series  D Preferred  Stock  a  Corporation 
Notice of the occurrence of such Optional Redemption Event and of the redemption
right set forth  herein  arising  as a result thereof.
The Corporation Notice shall set forth:

                                 (A)  the date by which  the optional redemption
right must be  exercised,  which date shall be at least 30 days after the date 
such Corporation Notice is given, and

                                 (B)  a description of the procedure  (set forth
below) which each such holder must follow to exercise such holder's optional 
redemption right.

                            No failure of the Corporation  to give a Corporation
Notice or defect therein shall limit the right of any holder of shares of Series
D Preferred Stock to exercise the optional  redemption right or affect the 
validity of the  proceedings  for the  redemption of such holder's shares of 
Series D Preferred Stock.

                            (ii) To exercise  its  optional  redemption  right, 
each holder of  outstanding shares of Series D Preferred Stock shall deliver to 
the Corporation on or before the thirtieth  day after a Corporation  Notice is 
given to such holder (or if no Corporation Notice has been given to such holder,
within forty days after such holder  first learns of the Optional  Redemption  
Event) a Holder  Notice to the Corporation  setting  forth  the  name of such  
holder  and the  number  of such holder's shares of Series D Preferred Stock to 



                                       19
<PAGE>

be redeemed.  A Holder Notice may be revoked by such holder  giving such  Holder
Notice by giving  notice of such revocation to the Corporation at any time prior
to the time the Corporation pays the Optional Redemption Price to such holder.

                            (iii) If a holder of  shares of Series D  Preferred 
Stock  shall  have  given a Holder  Notice, on the date which is three  Business
Days after the date such Holder  Notice is given  (or such  later  date as such 
holder  surrenders  such holder's  certificates  for the shares of Series D 
Preferred Stock redeemed) the Corporation shall make payment in immediately  
available funds of the applicable Optional Redemption Price to such account as 
specified by such holder in writing to the Corporation at least one Business Day
prior to the  applicable  redemption  date.  A holder of shares of  Series  D 
Preferred Stock which are redeemed pursuant to this  Section  shall not be  
entitled to payment of the Optional Redemption Price of such  shares of Series D
Preferred  Stock until such holder  shall have surrendered  the  certificate(s) 
for such shares of Series D Preferred Stock to the  Corporation  or, in the case
of the loss,  theft or destruction of any such certificate, given indemnity in
accordance with Section 11. (iv) Notwithstanding any other provision of this 
Amended and Restated  Certificate of  Incorporation, if an Optional  Redemption 
Event occurs by reason of the occurrence of an event described  in clause  (1), 
(2) or (3) of the  definition  of the term  Optional Redemption  Event, and such
occurrence  is by reason  of events  which are not solely within the control of 
the  Corporation,  the  Corporation  shall have the right to give a Control  
Notice to the  holders of shares of Series D  Preferred Stock at any time after 
such Optional  Redemption  Event occurs and prior to the earlier of (1) the date
on which all  holders  of shares of Series D  Preferred Stock who had the right 
(other than as limited by this Section  7(c)(ii)(b))  to require  redemption  of
any shares of Series D Preferred  Stock by reason of the occurrence of such 
Optional  Redemption  Event no longer have such right and (2) the applicable  
Optional Redemption Date by reason of the earliest Holder Notice given by any  
holder of shares  of  Series D  Preferred  Stock by reason of such Optional  
Redemption Event. If the Corporation  timely gives such Control Notice and an  
Adjustment  Notice  (which may be  combined  in a single  notice) to the holders
of shares of Series D Preferred  Stock, then in lieu of payment of the Optional 
Redemption  Price by reason of any such Optional Redemption Event and commencing
on the first date on which such Optional  Redemption Event occurs the following 
adjustments shall take effect:

                            (A)  In  the  case of  an Optional Redemption  Event
described in clause (1) of the definition of the term Optional Redemption Event,
for a period of 180 days after the occurrence of such Optional Redemption  Event
(i) the Series D Conversion  Price will be 80% of the amount which the Series D 
Conversion  Price would  otherwise be and (ii) the cumulative dividend shall 
accrue on each share of the Series D Preferred  Stock at the rate of $180 per 
annum.

                            (B)  In  the case of  an  Optional Redemption  Event
described in clause (2) of the definition of the term Optional Redemption Event,
for so long as such Optional  Redemption Event continues (i) the  Series D  
Conversion  Price  will be 80% of the  amount  which the Series D Conversion  
Price would  otherwise  be and (ii) the  cumulative  dividend  shall accrue on 
each share of Series D Preferred Stock at the rate of $180 per annum.




                                       20
<PAGE>

                            (C)  In  the case  of  an Optional Redemption  Event
described in clause (3) of the definition of the term Optional Redemption Event,
for so long as any shares of Preferred Stock are outstanding (i) the Series D  
Conversion  Price will be 70% of the amount which the Series D Conversion  Price
would  otherwise  be and (ii) the  cumulative  dividend  shall accrue on each 
share of Series D Preferred Stock at the rate of $300 per annum.

           For purposes of this Section 7(c)(ii)(b)(iv),  an Optional Redemption
Event described in clause (1), (2) or (3) of the definition of the term Optional
Redemption  Event shall be deemed to have occurred by reason of events which are
not  solely  within the  control  of the  Corporation  if a  requirement  of the
Corporation to redeem,  or a right of any holder of shares of Series D Preferred
Stock to require  redemption  of,  shares of Series D Preferred  Stock by reason
thereof would result in the Corporation  being required to classify the Series D
Preferred  Stock  as  redeemable  preferred  stock  on a  balance  sheet  of the
Corporation   prepared  in  accordance   with  Generally   Accepted   Accounting
Principles, and, in the case of an Optional Redemption Event described in clause
(3) of the definition of the term Optional  Redemption  Event,  the Board or the
stockholders  of the  Corporation do not have the right to approve or disapprove
the transactions resulting in such event.

                        (d) Other.

                            (1) If the Corporation fails to pay in full when due
the  Optional  Redemption Price for the number of shares of Series D Preferred 
Stock specified in a Holder Notice, then the amount thereof shall bear interest 
to the extent not prohibited by  applicable  law at the rate of 12% per annum 
from the due date thereof until paid in full.

                            (2) In connection  with a redemption  pursuant  to
these  Sections  7(c)(ii)  of  less  than  all  of  the  shares  of  Series  D
Preferred Stock evidenced by a particular certificate, promptly, but in no event
later than  three  Business  Days after  surrender  of such  certificate  to the
Corporation,   the  Corporation  shall  issue  and  deliver  to  such  holder  a
replacement  certificate for the shares of Series D Preferred Stock evidenced by
such  certificate  which have not been redeemed.  

                            (3) A Holder Notice given by a holder of shares of 
Series D Preferred Stock shall be deemed for all purposes to be in proper form 
unless the Corporation  notifies such holder in writing within three  Business 
Days after such Holder Notice has been given (which notice shall specify all 
defects in the Holder Notice),  and any Holder Notice containing any such defect
shall  nonetheless  be  effective  on the date given if such holder promptly 
undertakes in writing to correct all such defects.  Notwithstanding the absence 
of any such undertaking  from such holder, no such claim of error shall limit or
delay performance of the Corporation's obligation to redeem all shares of Series
D Preferred Stock not in dispute.
           


                                       21
<PAGE>

           8.  Conversion.

               a.   Series A Preferred  Stock. The holders of Series A Preferred
Stock have conversion rights as follows:

                    (i)  Right  to  Convert.  Each  share of Series A Preferred 
Stock shall be convertible  into  one  share of Common Stock, as  adjusted   for
any  stock  dividends,  combinations  or splits  with  respect  to such  shares,
provided,  however,  that the minimum number of shares which may be converted at
anyone time shall be 75,000  shares or such lesser  number of shares as shall be
then outstanding.

                    (ii) Automatic Conversion.  Each share of Series A Preferred
Stock shall automatically be converted into Common Stock, upon the earlier to 
occur of:

                         (A)  immediately  in the event  that at any time  prior
to July 23,  1999,  the closing sale price (the "Closing Sale Price") of the 
Corporation's Common Stock (as  listed on the  Nasdaq  National  Market) has for
a period  of sixty  (60) consecutive  trading days exceeded the Original Issue 
Price,  which event shall be  disclosed  to each  holder  of the  Series A  
Preferred  Stock  by  written notification  from the  Corporation,  in which  
event  each  share of  Series A Preferred  Stock  shall  automatically  be  
converted  into one share of Common Stock,  as  appropriately  adjusted for any 
stock  dividends,  combinations  or splits with respect to such shares of Common
Stock; or

                         (B) July 23, 1999,  in which event each share of Series
A Preferred  Stock shall  automatically  be converted into such number of shares
of Common  Stock as equals  the Original  Issue  Price  divided  by  the 
weighted-average  Closing Sale Price for the sixty (60) consecutive trading days
ending two days prior to July 23, 1999, but in no event more than the  Original 
Issue Price  divided by $6.00,  in each case as appropriately  adjusted for any 
stock dividends,  combinations or splits with respect to such shares of Common 
Stock.




                                       22
<PAGE>

                    (iii)  Mechanics of Conversion.  Before any holder of Series
A  Preferred  Stock  shall be entitled to convert the same into shares of Common
Stock,  he shall  surrender  the  certificate  or  certificates therefor,  duly 
endorsed,  at the office of this  Corporation or of any transfer agent for the 
Series A Preferred  Stock,  and shall give written notice by mail, postage 
prepaid, or  by  facsimile,   confirmed by mail, to this  Corporation  at  its 
principal  corporate office, of the election to convert the same and shall state
therein the name or names in which the certificate or certificates for shares of
Common Stock are to be issued.  This  Corporation  shall, as soon as practicable
thereafter,  issue and  deliver  at such  office to such  holder of the Series A
Preferred  Stock, or to the nominee or nominees of such holder, a certificate or
certificates for the number of shares of Common Stock to which such holder shall
be  entitled as  aforesaid.  Such  conversion  shall be deemed to have been made
immediately  prior to the close of business on the date of such surrender of the
Series A Preferred Stock to be converted, or in the case of automatic conversion
pursuant to Section 8(a)(ii),  ten (10) days following  written  notification as
provided in Section 8(a)(ii),  and the person or persons entitled to receive the
shares of Common Stock  issuable upon such  conversion  shall be treated for all
purposes as the record  holder or holders of such  shares of Common  Stock as of
such date.

                    (iv)   Adjustments  to  Conversion Ratio for Stock Dividends
and for  Combinations  or  Subdivisions of Common Stock. In the event that this 
Corporation at any time or from time to time after the purchase date of the 
Series A Preferred shall declare or pay, without consideration,  any dividend on
the Common Stock  payable in Common Stock or in any right to acquire Common 
Stock  for no  consideration,  or  shall  effect  a  subdivision  of the
outstanding  shares of Common  Stock  into a greater  number of shares of Common
Stock (by stock  split,  reclassification  or  otherwise  than by  payment  of a
dividend in Common  Stock or in any right to acquire  Common  Stock),  or in the
event the outstanding  shares of Common Stock shall be combined or consolidated,
by  reclassification  or  otherwise,  into a lesser  number  of shares of Common
Stock,  then the  number  of  shares of Common  Stock  into  which the  Series A
Preferred  Stock  can  be  converted  shall  be  proportionately   decreased  or
increased,  as appropriate.  In the event that this Corporation shall declare or
pay,  without  consideration,  any dividend on the Common  Stock  payable in any
right to acquire Common Stock for no consideration then the Corporation shall be
deemed to have made a dividend  payable  in Common  Stock in an amount of shares
equal to the maximum  number of shares  issuable upon exercise of such rights to
acquire Common Stock.

                    (v)    Adjustments for Reclassification  and Reorganization.
If the Common Stock  issuable  upon  conversion of the Series A Preferred  Stock
shall be changed into the same or a different  number of shares of any other  
class or classes of stock, whether  by capital  reorganization, reclassification
or otherwise (other than a subdivision or combination of shares provided  for in
Section  8(a)(iv)  above or a merger  or other  reorganization referred to in 
Section 5(f) above),  the number of shares of such other class or classes of 
stock into which the Series A Preferred  Stock  shall be  convertible  shall,   
concurrently   with  the   effectiveness  of  such   reorganization  or
reclassification,  be  proportionately  adjusted  so that the Series A Preferred
Stock shall be convertible into, in lieu of the number of shares of Common Stock
which the holders would  otherwise  have been  entitled to receive,  a number of
shares of such  other  class or  classes  of stock  equivalent  to the number of
shares of Common  Stock that would have been  subject to receipt by the  holders
upon conversion of the Series A Preferred Stock immediately before that change.



                                       23
<PAGE>

                    (vi)    No  Impairment.   This  Corporation  will   not, 
 by  amendment   of  its   Certificate   or  through  any   reorganization,
recapitalization,  transfer of assets, consolidation, merger, dissolution, issue
or sale of securities or any other voluntary action,  avoid or seek to avoid the
observance  or  performance  of any of the  terms to be  observed  or  performed
hereunder by this Corporation, but will at all times in good faith assist in the
carrying out of all the provisions of this Section 8(a)(iv) and in the taking of
all such  action as may be  necessary  or  appropriate  in order to protect  the
Conversion  Rights  of the  holders  of the  Series A  Preferred  Stock  against
impairment.

                    (vii)  No  Fractional  Shares  and  Certificate  as  to 
Adjustments.

                        (a)  No  fractional  shares  shall  be  issued  upon
conversion  of the Series A Preferred  Stock,  and the number of shares of
Common Stock to be issued shall be rounded to the nearest  whole share.  Whether
or not fractional  shares are issuable upon such conversion  shall be determined
on the basis of the total  number of Series A  Preferred  Stock the holder is at
the time  converting  into Common Stock and the number of shares of Common Stock
issuable upon such aggregate conversion.

                        (b)  Upon   the   occurrence  of each   adjustment  or
readjustment of the number of shares of Common Stock into which the Series A
Preferred  Stock  can be  converted  pursuant  to this  Section  8(a)(iv),  this
Corporation,   at  its  expense,  shall  promptly  compute  such  adjustment  or
readjustment in accordance with the terms hereof and prepare and furnish to each
holder of Series A Preferred  Stock a certificate  setting forth such adjustment
or  readjustment  and showing in detail the facts upon which such  adjustment or
readjustment is based.  This Corporation  shall, upon the written request at any
time of any holder of Series A Preferred Stock, furnish or cause to be furnished
to such  holder  a like  certificate  setting  forth  (A)  such  adjustment  and
readjustment, (B) the conversion ratio at the time in effect, and (C) the number
of shares of Common Stock and the amount, if any, of other property which at the
time would be received upon the conversion of the Series A Preferred Stock.

                     (viii)    Notices  of  Record  Date.   In  the event of any
taking by this Corporation of a record of the holders of any class of securities
for the  purpose of  determining  the  holders  thereof  who are entitled  to  
receive  any  dividend  (other  than a  cash  dividend)  or  other distribution,
any right to subscribe  for,  purchase or otherwise  acquire any shares of stock
of any class or any other securities or property, or to receive any other right,
this  Corporation  shall  mail to each  holder  of  Series A Preferred Stock, at
least twenty (20) days prior to the date specified therein, a notice  specifying
the date on which  any such  record is to be taken for the purpose of such 
dividend, distribution or right, and the amount and character of such dividend, 
distribution or right.

                    (ix) Reservation  of Stock Issuable  Upon  Conversion.  This
Corporation  shall at all times reserve and keep available out of its authorized
but unissued  shares of Common Stock solely for the purpose of effecting  the  
conversion  of the Series A Preferred  Stock such number of its shares of Common
Stock as shall from time to time be  sufficient  to effect the conversion of all
outstanding  shares  of  the Series A Preferred Stock;  and if at any time the 
number of authorized but unissued shares of Common Stock shall not be sufficient
to effect the  conversion of all the then outstanding  Series A Preferred Stock,
in addition to such other remedies as shall be available to the holder  of such 
Series A  Preferred  Stock,  this  Corporation  will  take such corporate action
as may, in the opinion of its counsel, be necessary to increase its authorized  
but unissued  shares of Common Stock to such number of shares as shall be 
sufficient for such purposes.



                                       24
<PAGE>

                     (x)  Notices.   Any  notice  required  by  the
provisions  of this  Section  8(a)(iv)  to be given to the  holders  of Series A
Preferred  Stock shall be deemed given if  deposited in the United  States mail,
postage prepaid, and addressed to each holder of record at his address appearing
on the books of this Corporation.

                b.   Series  C  Preferred  Stock.  The  holders  of
Series C Preferred Stock have conversion rights as follows:

                     (i)  Conversion  at the Option of the  Holder.
At any time at the option of the holder, Commencing twelve (12) months after the
Issuance  Date,  the holders of the Series C Preferred  Stock may convert at any
time all or from time to time any part of their  outstanding  shares of Series C
Preferred  Stock  into that  number of fully  paid and  nonassessable  shares of
Common  Stock  (calculated  as to each  conversion  to the nearest  1/100th of a
share) as equals the greater of (A) 16.6667  shares of Common  Stock or (B) such
number of shares of Common  Stock as  equals  $100.00  divided  by the  Series C
Conversion Price on the applicable Series C Conversion Date.

                     (ii) Mandatory   Conversion.   Each  share  of
Series C Preferred Stock shall automatically  convert, on the fourth anniversary
of the Issuance Date, into that number of fully paid and nonassessable shares of
Common  Stock  (calculated  as to each  conversion  to the nearest  1/100th of a
share) as equals the greater of (A) 16.6667  shares of Common  Stock or (B) such
number of shares of Common  Stock as  equals  $100.00  divided  by the  Series C
Conversion Price on the applicable Series C Conversion Date.

                     (iii)  Mechanics  of  Conversion.  Before any holder of 
Series C Preferred  Stock shall be entitled to convert the same into shares
of Common Stock, he shall  surrender the  certificate or certificates  therefor,
duly  endorsed,  at the office of the  Transfer  Agent,  and shall give  written
notice by mail,  postage  prepaid,  or by  facsimile,  confirmed by mail, to the
Transfer Agent at its principal corporate office, of the election to convert the
same and  shall  state  therein  the name or names in which the  certificate  or
certificates  for  shares of Common  Stock are to be  issued.  This  Corporation
shall,  as soon as  practicable  thereafter,  issue and  deliver  or cause to be
issued and delivered to such holder of the Series C Preferred  Stock,  or to the
nominee or nominees of such holder, a certificate or certificates for the number
of shares of Common Stock to which such holder  shall be entitled as  aforesaid.
Such conversion shall be deemed to have been made immediately prior to the close
of  business  on the  applicable  Conversion  Date,  and the  person or  persons
entitled to receive the shares of Common  Stock  issuable  upon such  conversion
shall be treated for all purposes as the record holder or holders of such shares
of Common Stock as of such date;  provided,  however,  that a holder of Series C
Preferred  Stock shall not be  entitled  to receive  the shares of Common  Stock
issuable upon any such  conversion  of shares of Series C Preferred  Stock until
such holder  surrenders to the Corporation or the Transfer Agent the certificate
for the shares of Series C Preferred Stock so converted.



                                       25
<PAGE>

                      (iv)   Adjustments  to  Conversion   Ratio  for  Stock  
Dividends and for  Combinations  or  Subdivisions  of Common Stock.  In the
event that this  Corporation at any time or from time to time after the purchase
date of the Series C Preferred shall declare or pay, without consideration,  any
dividend on the Common Stock  payable in Common Stock or in any right to acquire
Common  Stock  for no  consideration,  or  shall  effect  a  subdivision  of the
outstanding  shares of Common  Stock  into a greater  number of shares of Common
Stock (by stock  split,  reclassification  or  otherwise  than by  payment  of a
dividend in Common  Stock or in any right to acquire  Common  Stock),  or in the
event the outstanding  shares of Common Stock shall be combined or consolidated,
by  reclassification  or  otherwise,  into a lesser  number  of shares of Common
Stock,  then the  number  of  shares of Common  Stock  into  which the  Series C
Preferred  Stock  can or  shall be  converted,  to the  extent  such  number  is
determined   under  either   Section   8(b)(i)(A)  or   8(b)(ii)(A),   shall  be
proportionately  decreased or increased, as appropriate.  In the event that this
Corporation  shall declare or pay,  without  consideration,  any dividend on the
Common Stock payable in any right to acquire  Common Stock for no  consideration
then the Corporation  shall be deemed to have made a dividend  payable in Common
Stock in an amount of shares equal to the maximum number of shares issuable upon
exercise  of  such  rights  to  acquire  Common  Stock.
   
                     (v)   Adjustments for Reclassification and  Reorganization.
If the Common  Stock  issuable  upon  conversion  of the Series C Preferred
Stock  shall be  changed  into the same or a  different  number of shares of any
other   class  or   classes  of  stock,   whether  by  capital   reorganization,
reclassification or otherwise (other than a subdivision or combination of shares
provided  for in  Section  8(b)(ii)  above or a merger  or other  reorganization
referred to in Section 4(f) above),  the number of shares of such other class or
classes of stock into which the Series C Preferred  Stock  shall be  convertible
shall,   concurrently   with  the   effectiveness  of  such   reorganization  or
reclassification,  be  proportionately  adjusted  so that the Series C Preferred
Stock shall be convertible into, in lieu of the number of shares of Common Stock
which the holders would  otherwise  have been  entitled to receive,  a number of
shares of such  other  class or  classes  of stock  equivalent  to the number of
shares of Common  Stock that would have been  subject to receipt by the  holders
upon conversion of the Series C Preferred Stock immediately  before that change.

                     (vi) No Impairment. This Corporation will not, by amendment
of  its  Certificate  or  through  any  reorganization,   recapitalization,
transfer  of  assets,  consolidation,  merger,  dissolution,  issue  or  sale of
securities or any other voluntary action,  avoid or seek to avoid the observance
or performance of any of the terms to be observed or performed hereunder by this
Corporation,  but will at all times in good faith  assist in the carrying out of
all the  provisions of this Section 8(b) and in the taking of all such action as
may be necessary or appropriate in order to protect the Conversion Rights of the
holders of the Series C Preferred Stock against impairment.

                     (vii) No  Fractional  Shares and Certificate  as to  
Adjustments.  

                              (A) No fractional  shares shall be issued upon  
conversion of the Series C Preferred Stock, but, in lieu of any fraction of
a share of Common  Stock  which  would  otherwise  be issuable in respect of the
aggregate  number  of  shares  of  Series  C  Preferred  Stock  surrendered  for
conversion at one time by the same holder,  the Corporation shall pay in cash to


                                       26
<PAGE>

such holder at the time of issuance of shares of Common Stock in connection with
such  conversion  an amount  equal to the product of (i) an amount  equal to the
average  closing  price of a share of Common Stock for the 10 Trading Day period
ending three Trading Days prior to the Conversion  Date times (ii) such fraction
of a share of Common Stock.  Whether or not fractional  shares are issuable upon
such conversion shall be determined on the basis of the total number of Series C
Preferred  Stock the holder is at the time  converting into Common Stock and the
number of shares of Common Stock issuable upon such aggregate conversion.

                              (B)  Upon   the    occurrence   of   each
adjustment  or  readjustment  of the number of shares of Common Stock into which
the Series C Preferred  Stock can be converted  pursuant to this  Section  8(b),
this  Corporation,  at its expense,  shall promptly  compute such  adjustment or
readjustment  in accordance  with the terms hereof and, upon the written request
at any time of any holder of Series C  Preferred  Stock,  prepare and furnish to
such holder of Series C Preferred  Stock a  certificate  setting  forth (A) such
adjustment  or  readjustment  and  showing  in detail  the facts upon which such
adjustment or  readjustment  is based,  (B) the conversion  ratio at the time in
effect,  and (C) the number of shares of Common Stock and the amount, if any, of
other  property  which at the time would be received upon the  conversion of the
Series C Preferred Stock.

                     (viii) Notices of Record Date. In the event of any taking 
by this  Corporation  of a record of the holders of any class of securities
for the purpose of determining  the holders  thereof who are entitled to receive
any dividend  (other than a cash dividend) or other  distribution,  any right to
subscribe for, purchase or otherwise acquire any shares of stock of any class or
any  other  securities  or  property,  or  to  receive  any  other  right,  this
Corporation  shall mail to each  holder of Series C  Preferred  Stock,  at least
twenty (20) days prior to the date specified  therein,  a notice  specifying the
date on which any such record is to be taken for the  purpose of such  dividend,
distribution  or  right,   and  the  amount  and  character  of  such  dividend,
distribution or right.

                    (ix)  Reservation of Stock Issuable Upon Conversion.  This 
Corporation  shall  at all  times  reserve  and keep  available  out of its
authorized  but  unissued  shares of Common  Stock solely for the purpose of (i)
effecting the  conversion of the Series C Preferred  Stock and (ii) of effecting
the issuance of any shares of Common  Stock  issuable  upon any  stock-for-stock
dividend  declared on the Series C Preferred Stock, such number of its shares of
Common  Stock  as  shall  from  time to time be  sufficient  to (a)  effect  the
conversion of all outstanding  shares of the Series C Preferred Stock and (b) to
effect  the  issuance  of  any  shares  of  Common  Stock   issuable   upon  any
stock-for-stock dividend declared on the Series C Preferred Stock; and if at any
time the number of authorized  but unissued  shares of Common Stock shall not be
sufficient  to (x) effect the  conversion of all the then  outstanding  Series C
Preferred  Stock or (y)  effect  the  issuance  of any  shares of  Common  Stock
issuable upon any  stock-for-stock  dividend  declared on the Series C Preferred
Stock,  then,  in addition to such other  remedies as shall be  available to the
holder  of such  Series C  Preferred  Stock,  this  Corporation  will  take such
corporate action as may, in the opinion of its counsel, be necessary to increase
its authorized  but unissued  shares of Common Stock to such number of shares as
shall be sufficient for such purposes.  




                                       27
<PAGE>

                    (x) Notices.  Any notice  required by the provisions of this
Section 8(b)to be given to the holders of Series C Preferred Stock shall be 
deemed given if deposited in the United States mail, postage prepaid, and 
addressed to each holder of record at his address appearing on the books of this
Corporation.

                c.  Series D Preferred  Stock. The holders of Series D Preferred
Stock shall have conversion rights as follows:

                    (i)  Conversion at the Option of the Holder.

                          (a)  Conversion  Right.  The  holders  of the Series D
Preferred  Stock may  convert at any time all or from time to time any part  of
their  outstanding  shares of Series D  Preferred  Stock  into fully  paid  and
nonassessable  shares of Common Stock and such other  securities and property as
hereinafter  provided.  Commencing  on  the  Issuance  Date,  and  at  any  time
thereafter,  each  share of Series D  Preferred  Stock may be  converted  at the
office of the  Corporation or at such additional  office or offices,  if any, as
the  Board of  Directors  may  designate,  into such  number  of fully  paid and
nonassessable  shares of Common Stock  (calculated as to each  conversion to the
nearest  1/100th of a share)  determined  by dividing  (x) the sum of (i) $1,000
plus (ii) an amount  equal to the accrued but unpaid  dividends  on the share of
Series D Preferred Stock being converted and any Arrearage Interest on dividends
thereon in arrears to the applicable  Series D Conversion Date by (y) the Series
D  Conversion  Price on the  applicable  Series  D  Conversion  Date;  provided,
however, that in no event shall any holder of shares of Series D Preferred Stock
be entitled to convert any shares of Series D Preferred  Stock in excess of that
number of shares of Series D Preferred Stock upon conversion of which the sum of
(1) the  number  of shares of Common  Stock  beneficially  owned by such  holder
(including shares of Common Stock  beneficially  owned by all Aggregated Persons
of such holder) (other than shares of Common Stock deemed  beneficially owned by
such holder or any Aggregated Person of such holder through the ownership of (x)
unconverted  shares  of Series D  Preferred  Stock  and (y) the  unconverted  or
unexercised  portion of any  instrument  which contains  limitations  similar to
those set forth in this  sentence)  and (2) the number of shares of Common Stock
issuable upon the conversion of the number of shares of Series D Preferred Stock
with respect to which the  determination  in this  proviso is being made,  would
result in beneficial ownership by such holder and all Aggregated Persons of such
holder of more than 4.9% of the outstanding shares of Common Stock.

                               (b)  Certain  Limitations  on Conversion Rights.
Notwithstanding   any  other   provision   of   this   Amended  and   Restated
Certificate of Incorporation, in no event shall any holder of shares of Series D
Preferred  Stock be entitled on any date to convert a number of shares of Series
D Preferred Stock in excess of that number of shares of Series D Preferred Stock
upon  conversion of which such holder and any  Aggregated  Person of such holder
would have acquired, through conversion of shares of Series D Preferred Stock or
otherwise,  a number  of shares  of  Common  Stock in  excess  of the  Converted
Restriction  Amount during the 30-day period ending on and including the date of
the  determination  being made pursuant to this Section  8(c)(i)(b)  (other than
shares  of  Common  Stock  deemed  beneficially  owned  by  such  holder  or any
Aggregated Person of such holder through the ownership of (x) unconverted shares
of Series D Preferred  Stock and (y) the  unconverted or unexercised  portion of
any  instrument  which contains  limitations  similar to those set forth in this
sentence).




                                       28
<PAGE>

                              (c)  Beneficial  Ownership.  For  purposes  of the
proviso to the second sentence of Section  8(c)(i)(b)and for purposes of Section
8(c)(i)(b),  (x)  beneficial  ownership  shall be determined in accordance  with
Section  13(d)  of the 1934  Act and  Regulation  13D-G  thereunder,  except  as
otherwise  provided  in clause  (1) of the  proviso to the  second  sentence  of
Section  8(c)(i)(b) or as provided in Section 8(c)(i)(b) and (y) the Corporation
shall be  entitled to rely,  and shall be fully  protected  in  relying,  on any
statement  or  representation  made by a holder of shares of Series D  Preferred
Stock to the Corporation in connection with a particular conversion, without any
obligation on the part of the  Corporation to make any inquiry or  investigation
or to examine its records or the  records of any  transfer  agent for the Common
Stock and without any liability of the Corporation with respect thereto.
                        
                         (ii) Other Provisions.

                              (a) The  holders of shares of  Series D  Preferred
Stock at the close of  business on the record  date for any  dividend payment to
holders of Series D Preferred  Stock  shall be entitled to receive the  dividend
payable   on  such   shares  on  the   corresponding   dividend   payment   date
notwithstanding  the conversion  thereof after the record date for such dividend
payment date or the Corporation's default in payment of the dividend due on such
dividend payment date; provided,  however, that the holder of shares of Series D
Preferred Stock converted during the period between the close of business on any
record  date  for a  dividend  payment  and  the  opening  of  business  on  the
corresponding  dividend  payment date must pay to the  Corporation,  within five
days after  receipt by such holder,  an amount equal to the dividend  payable on
such  shares  on such  dividend  payment  date if such  dividend  is paid by the
Corporation to such holder.  A holder of shares of Series D Preferred Stock on a
record date for a dividend  payment who (or whose  transferee)  converts  any of
such shares into shares of Common Stock on or after such  dividend  payment date
will receive the dividend  payable by the Corporation on such shares of Series D
Preferred  Stock on such dividend  payment date, and the converting  holder need
not make any  payment of the amount of such  dividend  in  connection  with such
conversion of shares of Series D Preferred  Stock.  Except as provided above, no
adjustment  shall be made in respect of cash dividends on Common Stock or Series
D Preferred  Stock that may be accrued and unpaid at the date of  conversion  of
shares of Series D Preferred Stock.

                              (b) The right of the holders of Series D Preferred
Stock to convert their shares shall be exercised by delivering(which may be made
by telephone line facsimile transmission, which shall be conclusively deemed for
all purposes of this Amended and Restated  Certificate of  Incorporation to have
been  given  on the date  sent if the  sender  shall  have  received  electronic
confirmation  of the receipt by the Series D Conversion  Agent of such facsimile
transmission) to the Series D Conversion  Agent a Series D Conversion  Notice at
the address or telephone line facsimile  number provided in the form of Series D
Conversion Notice set forth in Section 14(a) (or such other address or facsimile
number of the Series D Conversion  Agent as shall be provided by the Corporation
by notice to the holders of the shares of Series D Preferred Stock), with a copy
to the Corporation at its address or telephone line facsimile number provided in
or  pursuant  to Section  12;  provided,  however,  that any failure or delay in
giving a copy of a Series D  Conversion  Notice  to the  Corporation  shall  not
affect the validity of or Series D Conversion  Date for such Series D Conversion
Notice.  The number of shares of Common Stock to be issued upon each  conversion
of shares of  Series D  Preferred  Stock  shall be the  number  set forth in the
applicable Series D Conversion  Notice,  which number shall be conclusive absent



                                       29
<PAGE>

manifest error.  The Corporation  shall notify a holder who has given a Series D
Conversion Notice of any claim of manifest error within three Trading Days after
such holder  gives such Series D Conversion  Notice,  and no such claim of error
shall limit or delay performance of the  Corporation's  obligation to issue upon
such conversion the number of shares of Common Stock which are not in dispute. A
Series D Conversion Notice shall be deemed for all purposes to be in proper form
unless the  Corporation  notifies a holder of shares of Series D Preferred Stock
being converted within three Trading Days after a Series D Conversion Notice has
been given (which  notice shall  specify all defects in such Series D Conversion
Notice),  and any Series D Conversion  Notice  containing  any such defect shall
nonetheless  be effective on the date given if the  converting  holder agrees to
correct all such defects promptly.

                              (c) If a holder of Series D Preferred Stock elects
to convert any shares of Series D Preferred  Stock in accordance  with  Section
8(c)(i),  such  holder  shall not be required to  surrender  the  certificate(s)
representing  such  shares  of  Series  D  Preferred  Stock  physically  to  the
Corporation  unless all of the shares of Series D  Preferred  Stock  represented
thereby are so converted.  Each holder of shares of Series D Preferred Stock and
the Corporation shall maintain records showing the number of shares so converted
and the dates of such  conversions or shall use such other method,  satisfactory
to such holder and the Corporation,  so as to not require physical  surrender of
such  certificates  upon each such  conversion.  In the event of any  dispute or
discrepancy,   such  records  of  the  Corporation   shall  be  controlling  and
determinative in the absence of manifest error.  Notwithstanding  the foregoing,
if any shares of Series D Preferred Stock evidenced by a particular  certificate
therefor are converted as aforesaid,  the holder of Series D Preferred Stock may
not transfer the  certificate(s)  representing such shares of Series D Preferred
Stock unless such holder first physically  surrenders such certificate(s) to the
Corporation, whereupon the Corporation will forthwith issue and deliver upon the
order of such holder of shares of Series D Preferred Stock new certificate(s) of
like tenor,  registered  as such  holder of shares of Series D  Preferred  Stock
(upon  payment  by such  holder of shares  of  Series D  Preferred  Stock of any
applicable  transfer  taxes) may  request,  representing  in the  aggregate  the
remaining  number  of shares of Series D  Preferred  Stock  represented  by such
certificate(s). Each holder of shares of Series D Preferred Stock, by acceptance
of a certificate for such shares,  acknowledges and agrees that (1) by reason of
the provisions of this paragraph, following conversion of any shares of Series D
Preferred Stock represented by such certificate,  the number of shares of Series
D Preferred Stock represented by such certificate may be less than the number of
shares stated on such  certificate and (2) the Corporation may place one or more
legends on the  certificates for shares of Series D Preferred Stock which refers
to or describes the provisions of this paragraph.  The Corporation may by notice
to any  holder of shares of Series D  Preferred  Stock  require  such  holder to
surrender  the  certificate(s)  for such  holder's  shares of Series D Preferred
Stock  in  exchange  for  issuance  by  the  Corporation  of  one  or  more  new
certificates  for the  number  of  shares  evidenced  by the  certificate(s)  so
surrendered.

                              (d) The  Corporation  shall pay any transfer tax  
arising in connection  with any conversion of shares of Series D Preferred stock
except that the Corporation shall not, however, be required to pay any tax which
may be payable in respect of any  transfer  involved  in the issue and  delivery
upon  conversion of shares of Common Stock or other  securities or property in a
name other than that of the holder of the shares of the Series D Preferred Stock
being converted,  and the Corporation  shall not be required to issue or deliver
any such shares or other  securities or property  unless and until the Person or



                                       30
<PAGE>

Persons  requesting the issuance  thereof shall have paid to the Corporation the
amount of any such tax or shall  have  established  to the  satisfaction  of the
Corporation  that  such tax has  been  paid.  A holder  of  shares  of  Series D
Preferred  Stock who converts such shares shall be responsible for the amount of
any withholding tax payable in connection with such conversion.

                              (e) (1) The Corporation shall duly  reserve and at
all times prior to the Stockholder Approval will continue  to reserve 6,285,000
shares of its authorized and unissued Common Stock, free from preemptive rights,
for issuance upon  conversion of the shares of Series D Preferred Stock (subject
to reduction from time to time for shares of Common Stock issued upon conversion
of  shares  of  Series  D  Preferred  Stock).  From  and  after  the date of the
Stockholder  Approval,  the Corporation will duly reserve,  free from preemptive
rights, for issuance upon conversion of the shares of Series D Preferred Stock a
number of shares of its  authorized and issued Common Stock equal to 175% of the
number of shares of Common  Stock which would be issuable on  conversion  of all
authorized  shares of Series D Preferred  Stock on the  Issuance  Date if all of
such  shares  of  Series  D  Preferred  Stock  were  outstanding  on  such  date
(determined without regard to the limitations on conversion continued in Section
8(c)(i),  subject  to  reduction  from time to time for  shares of Common  Stock
issued upon  conversion of shares of Series D Preferred  Stock.  The Corporation
(and any successor corporation) shall take all action necessary so that a number
of shares of the  authorized  but unissued  Common Stock (or common stock in the
case of any successor corporation) equal to the number of shares of Common Stock
(or such common stock)  issuable upon conversion of the Series D Preferred Stock
outstanding, determined without regard to any limitation on beneficial ownership
contained in Section  8(c)(i),  are at all times reserved by the Corporation (or
any successor  corporation),  free from preemptive  rights, for such conversion,
subject to the provisions of the next succeeding  paragraph.  If the Corporation
shall issue any  securities  or make any change in its capital  structure  which
would  change the number of shares of Common  Stock into which each share of the
Series  D  Preferred  Stock  shall  be  convertible  as  herein  provided,   the
Corporation shall at the same time also make proper provision so that thereafter
there shall be a  sufficient  number of shares of Common  Stock  authorized  and
reserved,  free from preemptive rights, for conversion of the outstanding Series
D Preferred  Stock on the new basis. If at any time the number of authorized but
unissued  shares of Common Stock shall be insufficient to permit the Corporation
to reserve such number of shares of Common Stock, the Corporation promptly shall
seek such corporate  action as may, in the opinion of its counsel,  be necessary
to increase its authorized but unissued shares of Common Stock to such number of
shares as shall be sufficient to meet such requirement.

                                        (2)  The  Initial   Reserve   Amount
shall be allocated  among the shares of Series D Preferred  Stock at the time of
initial issuance thereof pro rata based on the total number of authorized shares
of Series D Preferred  Stock provided in Article  IV(B).  Each  certificate  for
shares of Series D Preferred Stock initially  issued shall bear a notation as to
the number of shares  constituting  the  portion of the Initial  Reserve  Amount
allocated  to the  shares  of  Series  D  Preferred  Stock  represented  by such
certificate  for  purposes  of  conversion   thereof.   Upon  surrender  of  any
certificate   for  shares  of  Series  D   Preferred   Stock  for   transfer  or
re-registration  thereof  (or, at the option of the holder of such  certificate,
for  conversion  pursuant  to Section  8(c)(i) of less than all of the shares of
Series D Preferred Stock  represented  thereby),  the  Corporation  shall make a
notation on the new certificate  issued upon such transfer or re-registration or
evidencing  such  unconverted  shares,  as the case may be, as to the  number of



                                       31
<PAGE>

shares of Common Stock from the Initial Reserve Amount  remaining  available for
conversion  of the  shares of Series D  Preferred  Stock  evidenced  by such new
certificate.  If any  certificate  for  shares  of Series D  Preferred  Stock is
surrendered for division into two or more certificates representing an aggregate
number of shares of Series D  Preferred  Stock  equal to the number of shares of
Series D Preferred  Stock  represented by the  certificate  so  surrendered  (as
reduced by any contemporaneous  conversion of shares of Series D Preferred Stock
represented by the certificate so surrendered),  each certificate issued on such
division  shall bear a notation  of the portion of the  Initial  Reserve  Amount
allocated thereto  determined by pro rata allocation of the remaining portion of
the Initial Reserve Amount  allocated to the certificate so surrendered.  If any
shares of Series D  Preferred  Stock  represented  by a single  certificate  are
converted in full pursuant to Sections  8(c),  all of the portion of the Initial
Reserve  Amount  allocated  to such  shares of Series D  Preferred  Stock  which
remains  unissued after such conversion  shall be  re-allocated  pro rata to the
outstanding  shares of Series D Preferred  Stock held of record by the holder of
record at the close of business on the date of such  conversion of the shares of
Series D Preferred Stock so converted,  and if there shall be no other shares of
Series D Preferred  Stock held of record by such holder at the close of business
on such date, then such portion of the Initial Reserve Amount shall be allocated
pro rata among the shares of Series D Preferred  Stock  outstanding at the close
of business on such date.  The provisions of this Section  8(c)(ii)(E)  shall be
inapplicable after the Stockholder  Approval is obtained.  If shares of Series D
Preferred  Stock are not issued to  MMC/GATX  in  accordance  with this  Article
IV(B),  the shares from the Initial  Reserve  Amount  which were  available  for
allocation to such shares of Series D Preferred  Stock shall be allocated to the
issued shares of Series D Preferred  Stock pro rata based on the amounts thereof
initially issued.

                              (f) (1) In case of any  consolidation or merger of
the  Corporation  with  any  other   corporation   (other  than  a  wholly-owned
subsidiary of the  Corporation)  in which the  Corporation  is not the surviving
corporation,  or in case of any sale or transfer of all or substantially  all of
the assets of the Corporation,  or in the case of any share exchange pursuant to
which all of the  outstanding  shares of Common Stock are  converted  into other
securities or property,  the  Corporation  shall make  appropriate  provision or
cause appropriate provision to be made so that each holder of shares of Series D
Preferred Stock then outstanding shall have the right thereafter to convert such
shares of Series D  Preferred  Stock  into the kind of shares of stock and other
securities  and  property  receivable  upon such  consolidation,  merger,  sale,
transfer,  or share  exchange  by a holder of shares of Common  Stock into which
such shares of Series D Preferred  Stock could have been  converted  immediately
prior to the effective date of such consolidation,  merger, sale,  transfer,  or
share  exchange  and on a basis which  preserves  the  economic  benefits of the
conversion  rights of the  holders  of shares of Series D  Preferred  Stock on a
basis as nearly as practical as such rights exist hereunder  prior thereto.  If,
in connection with any such  consolidation,  merger,  sale,  transfer,  or share
exchange,  each holder of shares of Common Stock is entitled to elect to receive
securities,  cash,  or other assets upon  completion  of such  transaction,  the
Corporation  shall  provide or cause to be  provided  to each holder of Series D
Preferred  Stock the right to elect prior to the completion of such  transaction
the  securities,  cash, or other assets into which the Series D Preferred  Stock
held  by  such  holder  shall  be  convertible  after  completion  of  any  such
transaction on the same terms and subject to the same  conditions  applicable to
holders of the Common Stock (including,  without limitation, notice of the right
to elect,  limitations  on the period in which such election  shall be made, and
the effect of failing to exercise the election).  Notwithstanding  the forgoing,



                                       32
<PAGE>

in connection with any such merger,  consolidation,  sale, transfer or exchange,
the  Corporation  shall  have  the  right,  in  lieu  of  making  provision  for
preservation  of economic  benefits of the  conversion  rights of the holders of
shares of Series D Preferred Stock, to redeem all outstanding shares of Series D
Preferred Stock immediately after completion of such transaction at a redemption
price  per  share of  Series D  Preferred  Stock in cash  equal to the  Business
Combination  Redemption  Price.  Such right of redemption  shall be exercised by
notice from the Corporation to the holders of shares of Series D Preferred Stock
stating that the  Corporation  is  exercising  its  redemption  right under this
Section  8(c)(ii)(f),  which notice shall be given at least 20 days and not more
than 30 days prior to completion of such transaction and shall specify that such
redemption  shall occur on the Business Day  immediately  following  the date of
completion of such  transaction.  On the date  specified in such notice (or such
later date as a holder of shares of Series D  Preferred  Stock  surrenders  such
holder's  certificates  for shares of Series D  Preferred  Stock  redeemed)  the
Corporation shall make payment in immediately  available funds of the applicable
Business  Combination  Redemption  Price to each  holder  of  shares of Series D
Preferred  Stock to be redeemed to such  account as  specified by such holder in
writing to the  Corporation  at least one  Business Day prior to such payment of
the  Business  Combination  Redemption  Price.  A holder  of  shares of Series D
Preferred Stock which are redeemed  pursuant to this Section  8(c)(ii)(f)  shall
not be entitled to payment of the Business Combination  Redemption Price of such
shares of Series D Preferred Stock until such holder shall have  surrendered the
certificate(s)  for such shares of Series D Preferred  Stock to the  Corporation
or, in the case of the loss, theft or destruction of any such certificate, given
indemnity in accordance  with Section 14. If the  Corporation  shall fail to pay
the Business  Combination  Redemption  Price of any shares of Series D Preferred
Stock in full when due,  then the  amount  thereof  shall bear  interest  to the
extent not  prohibited by  applicable  law at the rate of 12% per annum from the
due date thereof until paid in full.  Notwithstanding  the giving of a notice of
redemption pursuant to this Section 8(c)(ii)(f), each holder of shares of Series
D Preferred  Stock shall be entitled to convert in accordance  with this Section
8(c)(ii)(f)  any shares of Series D Preferred  Stock which are to be redeemed at
any time prior to (1) the redemption  date specified in the notice of redemption
or (2) if the Corporation fails to pay the Business Combination Redemption Price
in full to such  holder  when due,  the date on which the  Corporation  pays the
Business  Combination  Redemption Price in full to such holder for all shares of
Series D Preferred Stock to be redeemed from such holder.  The Corporation shall
not  effect  any  such  transaction  unless  it  shall  have  complied  with the
provisions of this  paragraph.  The above  provisions  shall  similarly apply to
successive consolidations, mergers, sales, transfers, or share exchanges.
                         
                                         (2)  Whenever   the  Corporation  shall
propose to take any of the actions specified in this Section 8(c)(ii)(f)(2), the
Corporation  shall  cause a notice to be  mailed,  at least 20 days prior to the
date on which the books of the  Corporation  will close or on which the security
holders entitled to participate in such  transaction will be determined,  to the
holders of record of the  outstanding  Series D  Preferred  Stock on the date of
such notice.  Such notice shall  specify the action  proposed to be taken by the
Corporation and the date as of which holders of record of the Common Stock shall
participate  in any such  actions or be entitled to exchange  their Common Stock
for securities or other property, as the case may be.

                                   (g) Upon receipt by the Series D  Conversion 
Agent from a  holder  of  shares  of  Series  D Preferred  Stock  of a  Series D
Conversion Notice, the Corporation shall issue and deliver or cause to be issued
and  delivered to or upon the order of such holder  certificates  for the Common



                                       33
<PAGE>

Stock  issuable  upon  such  conversion  by the close of  business  on the third
Trading Day after such Series D  Conversion  Notice is  received,  and as of the
close of business  on the date of such  receipt  such  holder (or such  holder's
assignee)  shall be deemed  to be the  holder  of  record  of the  Common  Stock
issuable  upon such  conversion,  and all rights  with  respect to the shares of
Series D Preferred Stock so converted shall forthwith terminate except the right
to receive the Common  Stock or other  securities,  cash,  or other  assets,  as
herein  provided,  on such  conversion.  If a holder of Series D Preferred Stock
shall have given a Series D Conversion  Notice in  accordance  with the terms of
this  Amended and  Restated  Certificate  of  Incorporation,  the  Corporation's
obligation to issue and deliver the  certificates for Common Stock issuable upon
such conversion shall be absolute and unconditional,  irrespective of any action
or inaction by the converting  holder to enforce the same, any waiver or consent
with respect to any provision thereof,  the recovery of any judgment against any
Person  or any  action  to  enforce  the  same,  any  failure  or  delay  in the
enforcement of any other  obligation of the Corporation to the holder of record,
or any setoff,  counterclaim,  recoupment,  limitation  or  termination,  or any
breach or alleged  breach by the holder or any other Person of any obligation to
the Corporation,  or any violation or alleged violation of law by such holder or
any other  Person,  and  irrespective  of any  other  circumstance  which  might
otherwise  limit such obligation of the Corporation to such holder in connection
with such  conversion;  provided,  however,  that nothing  herein shall limit or
prejudice  the right of the  Corporation  to pursue  any such claim in any other
manner permitted by applicable law.

           The occurrence of an event which requires an equitable  adjustment of
the Trading Price as contemplated  by the definition  thereof in Section 1 shall
in no way  restrict  or delay  the  right of any  holder  of  shares of Series D
Preferred  Stock to receive shares of Common Stock upon  conversion of shares of
Series D Preferred  Stock,  and the  Corporation  shall use its best  efforts to
implement each such  adjustment on terms  reasonably  acceptable to the Majority
Holders within two Trading Days after such occurrence.

           If the Corporation  fails to issue and deliver the  certificates  for
the Common Stock to the holder  converting shares of Series D Preferred Stock as
and when required to do so, in addition to any other liabilities the Corporation
may have  hereunder and under  applicable law (1) the  Corporation  shall pay or
reimburse  such  holder on demand  for all  out-of-pocket  expenses,  including,
without limitation,  reasonable fees and expenses of legal counsel,  incurred by
such  holder as a result of such  failure,  (2) the  Series D  Conversion  Price
applicable  to such  conversion  shall be reduced by  one-tenth  of a percentage
point from the Series D Conversion Price otherwise applicable to such conversion
for each  Trading  Day  during  the  period  from the date the  Corporation  was
required to deliver such shares of Common Stock to the date the  Corporation  so
delivers such shares of Common Stock; provided,  however, that in no event shall
any such reduction be made for any Trading Day in such period which is after the
date which is 120 days after the date the  Corporation  was  required to deliver
such shares of Common Stock in  connection  with such  conversion,  and (3) such
holder may by written  notice or oral  notice  (promptly  confirmed  in writing)
given at any time prior to delivery to such holder of the  certificates  for the
shares of Common  Stock  issuable  upon  such  conversion  of shares of Series D
Preferred Stock,  rescind such conversion,  whereupon such holder shall have the
right  to  convert  such  shares  of  Series D  Preferred  Stock  thereafter  in
accordance herewith; provided, however, that the Corporation shall not be liable
to any holder of shares of Series D Preferred  Stock under the preceding  clause
(1) or clause (2) to the extent the failure of the  Corporation to deliver or to
cause to be  delivered  such shares of Common Stock  results  from fire,  flood,
storm, earthquake,  shipwreck,  strike, war, acts of terrorism,  crash involving
facilities  of a common  carrier,  acts of God, or any similar event outside the
control of the  Corporation  (it being  understood that the action or failure to
act of the Series D  Conversion  Agent shall not be deemed an event  outside the
control of the  Corporation  except to the extent  resulting  from fire,  flood,



                                       34
<PAGE>

storm, earthquake,  shipwreck,  strike, war, acts of terrorism,  crash involving
facilities of a common  carrier,  acts of God, the  bankruptcy,  liquidation  or
reorganization of the Series D Conversion Agent under any bankruptcy, insolvency
or other  similar law or any similar  event  outside the control of the Series D
Conversion  Agent). A holder of shares of Series D Preferred Stock who has given
a Series D  Conversion  Notice shall  notify the  Corporation  in writing (or by
telephone  conversation,  confirmed in writing) as promptly as practicable after
becoming aware that shares of Common Stock issued upon such  conversion have not
been received as provided in this Section 8(c)(vii).

                         (h) No fractional  shares.  No  fractional  shares of
Common Stock shall be issued upon conversion of Series D Preferred Stock but, in
lieu of any  fraction  of a share of Common  Stock and the  related  right which
would  otherwise  be  issuable in respect of the  aggregate  number of shares of
Series D Preferred  Stock  surrendered  for  conversion  at one time by the same
holder, the Corporation shall pay in cash to such holder at the time of issuance
of shares of Common Stock in connection  with such conversion an amount equal to
the  product of (A) the  arithmetic  average  of the Market  Price of a share of
Common  Stock on the three  consecutive  Trading  Days ending on the Trading Day
immediately  preceding the Series D Conversion Date times (B) such fraction of a
share of Common Stock

      9.   Voting Rights.

           Except as  otherwise  required by law or expressly  provided  herein,
each share of Series A Preferred  Stock and Series C Preferred  Stock shall have
voting  rights  and powers  equal to the voting  rights and powers of the Common
Stock  (except as  otherwise  expressly  provided  herein or as required by law,
voting  together  with the Common Stock as a single class) and shall be entitled
to notice of any  stockholders'  meeting  in  accordance  with the Bylaws of the
Corporation.   Fractional  votes  shall  not,  however,  be  permitted  and  any
fractional voting rights resulting from the above formula (after aggregating all
shares into which shares of Series A Preferred  Stock,  Series C Preferred Stock
and Series D Preferred  Stock held by each holder could be  converted)  shall be
rounded to the nearest whole number (with one-half being rounded upward).

           Each holder of shares of Series A  Preferred  Stock shall be entitled
to the number of votes equal to the number of shares of Common  Stock into which
such shares of Series A Preferred Stock could then be converted.  Each holder of
shares of Series C Preferred  Stock shall be entitled  (i) during the first year
after  the  issuance  thereof  to six  votes  for each one  share  held and (ii)
thereafter,  to one vote for each share of Common Stock into which such share of
Series C Preferred  Stock is convertible on the record date for the matter to be
voted upon.  Each holder of Common  Stock shall be entitled to one vote for each
share of Common Stock held.

           Except as  otherwise  required by law or expressly  provided  herein,
shares of Series D Preferred Stock shall not be entitled to vote on any matter.



                                       35
<PAGE>


               a.  Series D Voting Rights and Restrictions.

                    (1) Certificate of  Incorporation; Certain Stock. The affir-
mative vote or written consent of the Majority  Holders, voting  separately as a
class, will be required for (i) any amendment, alteration, or repeal, whether by
merger or  consolidation  or  otherwise,  of the  Corporation's  Certificate  of
Incorporation if the amendment,  alteration,  or repeal materially and adversely
affects the rights,  preferences or privileges of the Series D Preferred  Stock,
or (ii) the  creation  or  issuance  of any  Senior  Dividend  Stock  or  Senior
Liquidation  Stock;  provided,  however,  that any  increase  in the  authorized
Preferred  Stock of the  Corporation  or the  creation and issuance of any stock
which is both Junior Dividend and Junior  Liquidation  Stock shall not be deemed
to affect  materially and adversely  such rights,  preferences or privileges and
any such  increase or creation and issuance may be made without any such vote by
the holders of Series D Preferred Stock except as otherwise required by law; and
provided further,  however,  that no such amendment,  alteration or repeal shall
(A) reduce the Optional Redemption Price, Redemption Price or the amount payable
to a holder of shares of Series D Preferred Stock pursuant to Section 3(c)(iii),
(B) reduce the  percentage  in, or otherwise  change the  definition of Majority
Holders, (C) change the method of calculating the Series D Conversion Price in a
manner  adverse to the holders of shares of Series D  Preferred  Stock or reduce
the number of shares of Common Stock  issuable upon any  conversion of shares of
Series D Preferred  Stock, or (D) amend,  modify or repeal any provision of this
Section 9(a)(1),  unless in each such case referred to in the preceding  clauses
(A) through (D) such amendment,  modification or repeal has been approved by the
affirmative vote or written consent of the holders of all outstanding  shares of
Series D Preferred Stock, voting separately or as a class.

                      (2)  Repurchases of Series D Preferred  Stock.  The  
Corporation  shall not repurchase or otherwise acquire any shares of Series
D Preferred Stock (other than pursuant to Section 7(c)(i) unless the Corporation
offers to repurchase or otherwise  acquire  simultaneously a pro rata portion of
each holder's  shares of Series D Preferred Stock for cash at the same price per
share.

                      (3)  Other.  So long as any shares of Series D Preferred
Stock are outstanding:

                          (a) Limitation on Indebtedness.  The Corporation will 
not itself,  and will not permit any subsidiary of the  Corporation to, create,
assume,  incur,  in any manner become liable in respect of,  including,  without
limitation,  by reason of any  business  combination  transaction,  or suffer to
exist (all of which are  referred to herein as  "incurring"),  any  Indebtedness
other than Permitted Indebtedness.

                          (b) Payment of  Obligations.  The Corporation will pay
and discharge,  and will cause each  subsidiary of the  Corporation  to pay and
discharge, all their respective material obligations and liabilities, including,
without limitation,  tax liabilities,  except where the same may be contested in
good faith by appropriate proceedings.



                                       36
<PAGE>

                          (c) Maintenance of Property; Insurance.

                              (i) The  Corporation  will  keep,  and will cause 
each subsidiary of the  Corporation  to keep, all material  property  useful and
necessary in its business in good working order and condition, ordinary wear and
tear excepted
     
                              (ii) The Corporation will maintain, and will cause
each subsidiary  of the  Corporation  to maintain,  with  financially  sound and
responsible insurance companies,  insurance in at least such amounts and against
such  risks as are  usually  insured  against in the same  geographic  region by
companies of comparable size that are engaged in the same or a similar business,
subject to customary deductibles.

                         (d) Conduct of Business and Maintenance of Existence.  
The Corporation   will  continue,   and  will  cause  each  subsidiary  of  the
Corporation  to  continue,  to engage in  business of the same  general  type as
conducted by the Corporation and such subsidiaries on December 9, 1998, the date
the  Certificate of Designation  for the Series D Preferred Stock was filed with
the Secretary of State of Delaware,  and will  preserve,  renew and keep in full
force and effect, and will cause each subsidiary of the Corporation to preserve,
renew and keep in full force and effect,  their respective  corporate  existence
and their  respective  material rights,  privileges and franchises  necessary or
desirable in the normal conduct of business.

                          (e) Compliance with Laws. The Corporation will comply,
and will cause each  subsidiary of the  Corporation to comply,  in all material
respects with all applicable laws, ordinances,  rules,  regulations,  decisions,
orders and  requirements  of  governmental  authorities  and courts  (including,
without limitation, environmental laws) except (i) where compliance therewith is
contested in good faith by appropriate  proceedings or (ii) where non-compliance
therewith could not reasonably be expected to have a material  adverse effect on
the business,  condition  (financial  or  otherwise),  operations,  performance,
properties  or  prospects of the  Corporation  and its  subsidiaries  taken as a
whole.

                          (f)  Investment  Company  Act.  The  Corporation will 
not be or  become  an  open-end  investment  trust,  unit  investment  trust or
face-amount  certificate  company that is or is required to be registered  under
Section 8 of the  Investment  Company Act of 1940, as amended,  or any successor
provision.
    
                          (g) Transactions with Affiliates. The Corporation will
not, and will not permit any  subsidiary  of the  Corporation  to,  directly  or
indirectly, pay any funds to or for the account of, make any investment (whether
by acquisition of stock or Indebtedness, by loan, advance, transfer of property,
guarantee  or  other  agreement  to  pay,  purchase  or  service,   directly  or
indirectly,  any  Indebtedness,  or  otherwise)  in,  lease,  sell,  transfer or
otherwise dispose of any assets, tangible or intangible,  to, or participate in,
or effect any  transaction  in connection  with,  any joint  enterprise or other
joint  arrangement  with, any Affiliate of the Corporation,  except, on terms to
the  Corporation  or such  subsidiary no less favorable than terms that could be
obtained  by the  Corporation  or such  subsidiary  from a Person that is not an
Affiliate  of the  Corporation,  as  determined  in good  faith by the  Board of
Directors.

          10. Status of Converted or Redeemed  Stock.  In the event any Series A
Preferred  Stock or Series C  Preferred  Stock shall be  converted   pursuan  to



                                       37
<PAGE>

Section 8(a) or 8(b),  respectively,  hereof,  the shares so converted  shall be
promptlycanceled  after the conversion thereof. All such shares shall upon their
cancellation  become  authorized but unissued  shares of Preferred Stock and may
bereissued  as  part  of a new  series  of  Preferred  Stock  to be  created  by
resolution or resolutions  of the Board of Directors,  subject to the conditions
and restrictions on issuance set forth herein.

          11.  Outstanding  Shares. For purposes of the Certificate of 
Designation for the Series D Convertible  Preferred Stock filed on December 9,
1998,  all shares of Series D  Preferred  Stock  shall be deemed  outstanding
except  (i) from the date a Series D  Conversion  Notice is given by a holder of
Series D Preferred  Stock, all shares of Series D Preferred Stock converted into
Common Stock and (ii) from the date of registration  of transfer,  all shares of
Series D Preferred  Stock held of record by the Corporation or any subsidiary or
Affiliate (as defined herein) of the Corporation (other than any original holder
of shares of Series D Preferred Stock) and (iii) from the applicable  Redemption
Date,  Optional  Redemption  Date or  date of  redemption  pursuant  to  Section
8(c)(ii)(f),  all shares of Series D Preferred Stock which are redeemed, so long
as in each case the  Redemption  Price,  Optional  Redemption  Price or Business
Combination  Redemption  Price,  as the case may be, of such  shares of Series D
Preferred  Stock  shall  have  been  paid by the  Corporation  as and  when  due
hereunder.  

         12. Notices.  Any notices required or permitted to be given under the 
terms of this Certificate of Incorporation shall be in writing and shall be
delivered personally (which shall include telephone line facsimile transmission)
or by courier,  and shall be deemed given upon  receipt,  (a) in the case of the
Corporation,  addressed to the  Corporation at 213 East Grand Avenue,  South San
Francisco,  California 94080,  Attention:  President and Chief Executive Officer
(telephone line facsimile  transmission  number (650)  873-8367),  or (b) in the
case of any  holder  of shares of Series D  Preferred  Stock,  at such  holder's
address or telephone line facsimile transmission number shown on the stock books
maintained by the  Corporation  with respect to the Series D Preferred  Stock or
such other  address as the  Corporation  shall  have  provided  by notice to the
holders of shares of Series D Preferred Stock in accordance with this Section or
any holder of shares of Series D  Preferred  Stock  shall have  provided  to the
Corporation in accordance with this Section.

          13.  Replacement of  Certificates.  Upon receipt by the Corporation of
evidence reasonably satisfactory to the Corporation of the ownership of and the 
loss,  theft,  destruction  or mutilation o f any  certificate  for shares   of
Series C  Preferred  Stock or  Series D  Preferred  Stock and (1) in the case of
loss,  theft  or  destruction,  of  indemnity  from  the  record  holder  of the
certificate  for such shares of Series C  Preferred  Stock or Series D Preferred
Stock  reasonably  satisfactory  in form to the  Corporation  (and  without  the
requirement  to  post  any  bond  or  other  security)  or (2) in  the  case  of
mutilation,  upon surrender and  cancellation of the certificate for such shares
of Series C Preferred Stock or Series D Preferred  Stock,  the Corporation  will
execute and deliver to such holder a new certificate for such shares of Series C
Preferred Stock or Series D Preferred Stock without charge to such holder.


                                       38
<PAGE>



          14.  Forms of Notices.

               a.  Notice of Conversion of Series D Convertible Preferred Stock.


                              NOTICE OF CONVERSION
                                       OF
                      SERIES D CONVERTIBLE PREFERRED STOCK
                                       OF
                          SHAMAN PHARMACEUTICALS, INC.

TO:   BankBoston, N.A.,
   as Conversion Agent
150 Royall Street
Canton, Massachusetts 02021
Attention:  Client Administration
Facsimile No.:  (781) 575-2549

cc:   Shaman Pharmaceuticals, Inc.
213 East Grand Avenue
South San Francisco, California  94080
Attention:  Chief Financial Officer
Facsimile No.: (650) 873-8367

           (1) Pursuant to the terms of the Series D Convertible Preferred Stock
(the "Preferred Stock"), of Shaman Pharmaceuticals, Inc., a Delaware corporation
(the  "Corporation"),  the undersigned  (the "Holder")  hereby elects to convert
_______________  shares of the  Preferred  Stock,  including  accrued and unpaid
dividends per share of $________  and Arrearage  Interest per share of $________
into  shares of Common  Stock,  $0.001 par value (the  "Common  Stock"),  of the
Corporation,  at a Series D  Conversion  Price  per  share  of  Common  Stock of
$________ or such other  securities  into which the Preferred Stock is currently
convertible.  Capitalized  terms used in this Notice and not  otherwise  defined
herein  have the  respective  meanings  provided  in the  Amended  and  Restated
Certificate of Incorporation.

           (2) The number of shares of Common Stock issuable upon the conversion
of  the   shares  of   Preferred   Stock  to  which  this   Notice   relates  is
__________________________.

           (3)  Check  (and  complete,  if  applicable)  one of the
following:

           /__/ (A) Set forth  below or on a  schedule  which  accompanies  this
           Notice  are  the  Trading  Prices  during  the   Measurement   Period
           applicable to this Notice and an indication of the Trading Price used
           to determine the Series D Conversion Price set forth above.





                                       39
<PAGE>




Date                                                  Trading Price

1.    __________________________              $____________________

2.    __________________________              $____________________

3.    __________________________              $____________________

4.    __________________________              $____________________

5.    __________________________              $____________________

6.    __________________________              $____________________

7.    __________________________              $____________________

8.    __________________________              $____________________

9.    __________________________              $____________________

10.   __________________________              $____________________

11.   __________________________              $____________________

12.   __________________________              $____________________


           /__/ (B) The  conversion to which this Notice relates is based on the
           fixed  Series D  Conversion  Price  specified  in  clause  (a) of the
           definition  of such term in the Amended and Restated  Certificate  of
           Incorporation.

           (4)  Please  issue  certificates  for the  number of shares of Common
Stock or other securities into which such number of shares of Preferred Stock is
convertible in the name(s)  specified  immediately below or, if additional space
is necessary, on an attachment hereto:

_________________________________         _________________________________
      Name                                      Name

_________________________________         _________________________________
      Address                                   Address

_________________________________         _________________________________
      SS or Tax ID Number                       SS or Tax ID Number



                                       40
<PAGE>

           (5) The undersigned  hereby  represents to the  Corporation  that the
exercise  of  conversion  rights  contained  in this Notice does not violate the
provisions  of  Section  8(b)  of  this  Amended  and  Restated  Certificate  of
Incorporation  relating to beneficial  ownership in excess of 4.9% of the Common
Stock.

           (6) If the shares of Common Stock  issuable  upon  conversion  of the
Preferred  Stock  have not been  registered  for resale  under the 1933 Act,  as
amended (the "1933 Act") and are not being  offered or sold pursuant to Rule 144
under the 1933 Act (or any  successor or  replacement  rule or  provision),  the
Holder  represents  and  warrants  that (i) the  shares of  Common  Stock not so
registered are being acquired for the account of the Holder for investment,  and
not with a view to, or for resale in connection  with,  the public  distribution
thereof other than pursuant to  registration  under the 1933 Act or an exemption
from  registration  under  the 1933  Act,  and that the  Holder  has no  present
intention  of  distributing  or  reselling  the  shares of  Common  Stock not so
registered  other  than  pursuant  to  registration  under  the  1933  Act or an
exemption  from  registration  under  the 1933 Act and  (ii)  the  Holder  is an
"accredited  investor" as defined in Regulation D under the 1933 Act. The Holder
further  agrees that (A) the shares of Common Stock not so registered  shall not
be sold or transferred  unless (i) they first shall have been  registered  under
the 1933 Act,  (ii) the  Corporation  first  shall have been  furnished  with an
opinion of legal  counsel  reasonably  satisfactory  to the  Corporation  to the
effect that such sale or transfer is exempt from the  registration  requirements
of the 1933 Act or (iii) such  shares are  offered or sold  pursuant to Rule 144
under the 1933 Act (or any successor or replacement rule or provision),  and (B)
until such shares are registered for resale under the 1933 Act, the  Corporation
may place a legend on the  certificate(s)  for the shares of Common Stock not so
registered to that effect and place a  stop-transfer  restriction in its records
relating to the shares of Common Stock not so registered, all in accordance with
the Exchange Agreement by which the Holder is bound.

Date _________________________      ________________________________
                                    Signature of Holder
                                    (Must be signed exactly as name
                                    appears on the Preferred Stock Certificate.)




                                       41
<PAGE>




                b.     Form of Redemption Notice.


                                REDEMPTION NOTICE
              (Section 7(a) of Amended and Restated Certificate of
                                 Incorporation)

TO:   _____________________________
           (Name of Holder)

           (1) Pursuant to the terms of the Series D Convertible Preferred Stock
(the "Preferred Stock"),  Shaman  Pharmaceuticals,  Inc., a Delaware corporation
(the "Corporation"),  hereby notifies the above-named holder (the "Holder") that
the  Corporation  is  exercising  its  right to redeem  _____________  shares of
Preferred  Stock  held by the  Holder in  accordance  with  Section  7(a) of the
Amended and Restated Certificate of Incorporation:

           (2)  The Redemption Date is December 30, 1998.

           (3)  The Redemption  Price per share of Preferred  Stock
is $_________.

           (4) Upon surrender to the Corporation of the  certificate(s)  for the
shares of  Preferred  Stock to be  redeemed  (but in no event  earlier  than the
Redemption Date), the Corporation will make payment of the applicable Redemption
Price in accordance with the Amended and Restated Certificate of Incorporation.

           (5)  Capitalized  terms used herein and not otherwise  defined herein
have the respective meanings provided in the Amended and Restated Certificate of
Incorporation.

                               SHAMAN PHARMACEUTICALS, INC.



                               By _______________________________
                                     Title:




                                       42
<PAGE>




                c.     Form of Corporation Notice.


                               CORPORATION NOTICE
             (Section 7(c)(i) of Amended and Restated Certificate of
                                 Incorporation)

TO:   _____________________________
           (Name of Holder)

           (1)  An  Optional  Redemption  Event  described  in the  Amended  and
Restated  Certificate of Incorporation (the "Amended and Restated Certificate of
Incorporation")  of Series D Convertible  Preferred  Stock, par value $0.001 per
share (the  "Preferred  Stock"),  of Shaman  Pharmaceuticals,  Inc.,  a Delaware
corporation (the "Corporation"), occurred on _____________________,  _______. As
a  result  of such  Optional  Redemption  Event,  the  above-named  holder  (the
"Holder")  is entitled to exercise its optional  redemption  rights  pursuant to
Section 7(c)(ii) of the Amended and Restated Certificate of Incorporation.

           (2)  The  Holder's  optional  redemption  right  must be
exercised on or before
__________________,__________.

           (3) At or before the date set forth in the preceding  paragraph  (2),
the Holder must deliver to the Corporation:

           (a)  a Holder  Notice,  in the form set forth in Section
      14(d)   of  the   Amended   and   Restated   Certificate   of
      Incorporation; and

           (b)  the  certificates for the shares of Preferred Stock
      to  be   redeemed,   duly   endorsed   for  transfer  to  the
      Corporation the shares to be redeemed.

           (4)  Capitalized  terms used herein and not otherwise  defined herein
have the respective meanings provided in the Amended and Restated Certificate of
Incorporation.


Date _________________________            SHAMAN PHARMACEUTICALS, INC.



                                       By__________________________
                                          Title:




                                       43
<PAGE>




                       d. Form of Holder Notice.


                                  HOLDER NOTICE
            (Section 7(c)(ii) of Amended and Restated Certificate of
                                 Incorporation)

TO:   SHAMAN PHARMACEUTICALS, INC.

           (1)  Pursuant  to the  terms of the  Series D  Convertible  Preferred
Stock,  par  value  $0.001  per  share  (the  "Preferred   Stock"),   of  Shaman
Pharmaceuticals,   Inc.,  a  Delaware  corporation  (the   "Corporation"),   the
undersigned  hereby  elects to exercise its right to require  redemption  by the
Corporation  pursuant to Sections 7(c)(ii)(a) and 7(c)(ii)(b) of the Amended and
Restated  Certificate of  Incorporation of  _______________  shares of Preferred
Stock at an  Optional  Redemption  Price per share in cash equal to the  product
obtained by  multiplying  (a) the sum of (i) $1,000 plus (ii) an amount equal to
$___________  for the  accrued  but unpaid  dividends  on each share of Series D
Preferred Stock to be redeemed and any Arrearage  Interest on dividends  thereon
in arrears to the date of redemption times (b) 118% .

           (2) The  aggregate  Optional  Redemption  Price of all shares of  
Preferred Stock to be redeemed from the undersigned is $_____________.

           (3)  Capitalized  terms used herein and not otherwise  defined herein
have the respective meanings provided in the Amended and Restated Certificate of
Incorporation.


Date: _______________________             NAME OF HOLDER:




                                       By____________________________
                                          Signature of Registered Holder
                                          (Must be signed exactly as name
                                          appears on the stock certificate.)




                                       44
<PAGE>




                e.       Form of Control Notice.


                                 CONTROL NOTICE
            (Section 7(c)(iv) of Amended and Restated Certificate of
                                 Incorporation)

TO:   _____________________________
           (Name of Holder)

           (1)  Pursuant  to the  terms of the  Series D  Convertible  Preferred
Stock,   par  value   $0.001  per  share   (the   "Preferred   Stock"),   Shaman
Pharmaceuticals,  Inc.,  a  Delaware  corporation  (the  "Corporation"),  hereby
notifies the  above-named  holder (the  "Holder")  that in  accordance  with the
Amended and Restated  Certificate of Incorporation and by reason of events which
are not solely within the control of the Corporation,  on  _____________(fill in
date) an Optional  Redemption  Event subject to Section  7(c)(ii)(b)(iv)  of the
Amended and Restated Certificate of Incorporation occurred.

           (2)  Attached  to this  Notice  is an  Auditors'  Determination  with
respect to the occurrence referred to in paragraph (1).

           (3)  Capitalized  terms used herein and not otherwise  defined herein
have the respective meanings provided in the Amended and Restated Certificate of
Incorporation.

Date: _________________________        SHAMAN PHARMACEUTICALS, INC.



                                       By________________________________
                                          Title:




                                       45
<PAGE>



                    f.  Form of Adjustment Notice.


                                ADJUSTMENT NOTICE
            (Section 7(c)(iv) of Amended and Restated Certificate of
                                 Incorporation)

VIA FACSIMILE

TO:   ____________________________
           (Name of Holder)

           (1)  Pursuant  to the  terms of the  Series D  Convertible  Preferred
Stock,   par  value   $0.001  per  share   (the   "Preferred   Stock"),   Shaman
Pharmaceuticals,  Inc., a Delaware corporation (the "Corporation"),  confirms to
the  above-named  holder (the  "Holder")  of shares of  Preferred  Stock that on
_______________  (fill in date) the  Corporation  gave the Holder and each other
holder of shares of  Preferred  Stock a Control  Notice in  accordance  with the
Amended and Restated  Certificate of  Incorporation  of the Preferred Stock (the
"Amended and Restated  Certificate of  Incorporation"),  and hereby notifies the
Holder of the adjustments set forth below.

           (2)  Effective on  _________(fill  in date),  the Series D Conversion
Price of the  Preferred  Stock is ____% (fill in  percentage)  of the amount the
Series D  Conversion  Price would  otherwise  be without  regard to  adjustments
pursuant to Section  7(c)(ii)(b)(iv) of the Amended and Restated  Certificate of
Incorporation.

           (3) Effective on _________(fill in date),  cumulative dividends shall
accrue on each outstanding share of Preferred Stock in the amount of $__________
per annum.

           (4) The foregoing  adjustments  to the Series D Conversion  Price and
the cumulative annual dividend amount will continue in effect until a subsequent
Adjustment Notice is given to the Holder.

           (5)  Capitalized  terms used herein and not otherwise  defined herein
have the respective meanings provided in the Amended and Restated Certificate of
Incorporation.


Date _________________________         SHAMAN PHARMACEUTICALS, INC.



                                       By___________________________
                                         Title:




                                       46
<PAGE>




           C.   Common Stock.

                1.  Dividend  Rights.  Subject to the prior rights of holders of
all  classes  of  stock  at the  time  outstanding  having  prior  rights  as to
dividends,  the holders of the Common shall be entitled to receive,  when and as
declared by the Board of Directors, out of any assets of the corporation legally
available  therefor,  such dividends as may be declared from time to time by the
Board of Directors.

                2.   Redemption.  The Common is not redeemable.

                3. Voting Rights.  The holder of each share of Common shall have
the right to one  vote,  and shall be  entitled  to notice of any  stockholders'
meeting  in   accordance   with  this  Amended  and  Restated   Certificate   of
Incorporation and the Bylaws of this corporation,  and shall be entitled to vote
upon such matters and in such manner as may be provided by law.

               4. Residual  Rights.  All rights accruing to the outstanding  
shares of the corporation not expressly provided for to the contrary herein
shall be vested in the Common.


                                    ARTICLE V

           Except as otherwise provided in this Amended and Restated Certificate
of  Incorporation,  in furtherance and not in limitation of the powers conferred
by statute,  the Board of  Directors is expressly  authorized  to make,  repeal,
alter,  amend  and  rescind  from  time to time any or all of the  Bylaws of the
corporation.


                                   ARTICLE VI

           The number of directors of the  corporation  shall be fixed from time
to time by a Bylaw or  amendment  thereof duly adopted by the Board of Directors
or by the stockholders.

           The Board of  Directors  shall be and is  divided  into two  classes,
Class I and  Class  II.  Such  classes  shall be as  nearly  equal in  number of
directors as possible. Each director shall serve for a term ending on the second
annual meeting  following the annual meeting at which such director was elected.
The foregoing  notwithstanding,  each  director  shall serve until his successor
shall have been duly  elected  and  qualified,  unless he shall  resign,  become
disqualified, disabled or shall otherwise be removed. Any director or the entire
Board of Directors may be removed,  with or without  cause,  by the holders of a
majority of the shares entitled to vote at an election of directors.

           At each  annual  election,  directors  chosen to succeed  those whose
terms then  expire  shall be of the same class as the  directors  they  succeed,
unless  by  reason  of any  intervening  changes  in the  authorized  number  of
directors,  the Board shall designate one or more directorships  whose term then
expires  as  directorships  of  another  class in order  more  nearly to achieve
equality of number of directors among the classes.



                                       47
<PAGE>

           Notwithstanding  the rule  that the two  classes  shall be as  nearly
equal in number of  directors  as  possible,  in the event of any  change in the
authorized  number of directors  each director then  continuing to serve as such
shall  nevertheless  continue as a director of the class of which he is a member
until the  expiration of his current term,  or his prior death,  resignation  or
removal. If any newly created directorship may,  consistently with the rule that
the two classes shall be as nearly equal in number of directors as possible,  be
allocated  to one of two  classes,  the Board  shall  allocate it to that of the
available  classes  whose term of office is due to expire at the  earliest  date
following such allocation.

                                   ARTICLE VII

           Elections  of  directors  need not be by  written  ballot  unless the
Bylaws of the corporation shall so provide.

                                  ARTICLE VIII

           Meetings of  stockholders  may be held within or outside of the State
of Delaware, as the Bylaws may provide. The books of the corporation may be kept
(subject  to any  provision  contained  in the  statutes)  outside  the State of
Delaware at such place or places as may be  designated  from time to time by the
Board of Directors or in the Bylaws of the corporation.

                                   ARTICLE IX

           A director of the corporation  shall not be personally  liable to the
corporation  or its  stockholders  for monetary  damages for breach of fiduciary
duty as a director,  except for liability  (i) for any breach of the  director's
duty of  loyalty  to the  corporation  or its  stockholders,  (ii)  for  acts or
omissions not in good faith or which involve intentional misconduct or a knowing
violation of law,  (iii) under Section 174 of the Delaware  General  Corporation
Law, or (iv) for any  transaction  from which the director  derived any improper
personal benefit.  If the Delaware General  Corporation Law is hereafter amended
to  authorize,  with the  approval of the  corporation's  stockholders,  further
reductions  in the  liability  of the  corporation's  directors  for  breach  of
fiduciary duty,  then a director of the corporation  shall not be liable for any
such breach to the fullest extent permitted by the Delaware General  Corporation
Law as so amended.  Any repeal or  modification  of the foregoing  provisions of
this  Article IX by the  stockholders  of the  corporation  shall not  adversely
affect any right or protection of a director of the corporation  existing at the
time of such repeal or modification.

                                    ARTICLE X

           The corporation  reserves the right to amend, alter, change or repeal
any   provision   contained  in  this  Amended  and  Restated   Certificate   of
Incorporation,  in the manner now or hereafter  prescribed  by statute,  and all
rights conferred on stockholders herein are granted subject to this reservation.




                                       48
<PAGE>

           IN  WITNESS  WHEREOF,   this  Amended  and  Restated  Certificate  of
Incorporation  has  been  signed  by the  President  and  the  Secretary  of the
corporation this 11th day of March, 1999.

                                    SHAMAN PHARMACEUTICALS, INC.



                                    By:  /s/ Lisa A. Conte
                                         ------------------------
                                         Lisa A. Conte, President





                                       49
<PAGE>



                          SHAMAN PHARMACEUTICALS, INC.
                                      PROXY

                  Annual Meeting of Stockholders, June 11, 1999

         This Proxy is Solicited on Behalf of the Board of Directors of
                          Shaman Pharmaceuticals, Inc.



          The undersigned revokes all previous proxies,  acknowledges receipt of
the Notice of the Annual Meeting of Stockholders  to be held on Friday, June 11,
1999 and the Proxy  Statement and appoints  Lisa A. Conte and G. Kirk Raab,  and
each of them, the Proxy of the undersigned,  with full power of substitution, to
vote all shares of Common  Stock or Preferred  Stock of Shaman  Pharmaceuticals,
Inc. (the "Company") which the undersigned is entitled to vote, either on his or
her own behalf or on behalf of any entity or entities,  at the Annual Meeting of
Stockholders  of the  Company  to be held at The  Embassy  Suites,  250  Gateway
Boulevard,  South San Francisco,  California,  94080 on Friday, June 11, 1999 at
9:00 A.M.  Pacific  Time  (the  "Annual  Meeting"),  and at any  adjournment  or
postponement thereof, with the same force and effect as the undersigned might or
could do if personally  present  thereat.  The shares  represented by this Proxy
shall be voted in the manner set forth on the reverse side.

1. To elect two Class I  directors  to serve on the Board of  Directors  for two
   years or until their respective successors are duly elected and qualified:

                                                         WITHHOLD
                                                         AUTHORITY
                                            FOR           TO VOTE
                                            ---           -------
            G. Kirk Raab
            Herbert H.  McDade, Jr.
            M. David Titus
            Loren D. Israelsen
          
2. FOR   AGAINST   ABSTAIN  To approve an amendment to the Company's Amended and
   Restated Certificate of Incorporation (the "Restated  Certificate") to effect
   a 20-for-1 reverse stock split of the Company's outstanding Common Stock;

3. FOR   AGAINST   ABSTAIN  To approve an amendment to the Company's Amended and
   Restated   Certificate   of  Incorporation (the "Restated  Certificate")  to
   increase  the number of authorized  shares of the Company's  Preferred  Stock
   by 10,000,000 shares, from 2,000,000 shares to 12,000,000 shares;

4. FOR   AGAINST   ABSTAIN  To approve an amendment to the Company's Amended and
   Restated   Certificate   of  Incorporation (the "Restated  Certificate")  to
   increase  the number of authorized  shares of  the Company's Common Stock by
   150,000,000 shares, from 70,000,000 shares to 220,000,000 shares;

5. FOR   AGAINST   ABSTAIN  To approve an amendment and restatement of the 
   Company's Restated Certificate to (i)delete the provision stating that a 
   transaction or series of transactions in which in excess of 50% of the 
   Company's voting power is transferred will be treated as a liquidation, 
   dissolution or winding up of the Company, for purposes of causing a required
   liquidation preference distribution to the holders of the Company's Preferred
   Stock, and (ii)delete the reference to the Series D Preferred Stock from the 
   section, to clarify that the section, as a result of the amendment in this 
   proposal, no longer applies to the Series D Preferred Stock;

6. FOR AGAINST ABSTAIN  To approve amendments to the Company's 1992 Stock Option
   Plan (the "1992  Plan")  which will  result in a series of  increases  to the
   number of shares  issuable  thereunder, provide a special  one-time option
   grant to the non-employee Board members, extend the terms of the 1992 Plan
   and increase the limit on the number of shares for which a participant may be
   granted options per calendar year;

7.  FOR AGAINST ABSTAIN  To ratify the Board of  Director's  selection of Ernst 
    & Young  LLP to  serve  as the Company's independent auditors for  the  year
    ending December 31,  1999; and

8. FOR AGAINST ABSTAIN In accordance with the discretion of the proxy holders,to
   act upon all  matters  incident  to the conduct of the meeting and upon other
   matters as may properly come before the meeting.



                                      1
<PAGE>

      The Board of Directors recommends a vote IN FAVOR OF each of the directors
listed  above  and a vote IN FAVOR OF the  other  proposals.  This  Proxy,  when
properly  executed,  will be voted as specified  above. If no  specification  is
made, this Proxy will be voted IN FAVOR OF the election of the directors  listed
above and IN FAVOR OF the other proposals.

      Please print the name(s) appearing on each share certificate(s) over which
      you have voting authority:________________________________________________
                                          (Print name(s) on certificate)

      Please sign your name:__________________________   Date:__________________
                             (Authorized Signature(s))




                                       2
<PAGE>


                                                            Exhibit A


                          SHAMAN PHARMACEUTICALS, INC.
                             1992 STOCK OPTION PLAN

                (As Restated and Amended through March 15, 1999)



                                   ARTICLE ONE
                                     GENERAL

I. PURPOSE OF THE PLAN

     A. This 1992  Stock  Option  Plan  ("Plan")  is  intended  to  promote  the
interests  of  Shaman   Pharmaceuticals,   Inc.,  a  Delaware  corporation  (the
"Company"),  by providing a method whereby  eligible  individuals may be offered
the opportunity to acquire a proprietary  interest,  or otherwise increase their
proprietary  interest,  in the Company as an incentive for them to remain in the
service of the Company (or its parent or subsidiary corporations).

     B. The Plan became  effective on the date on which shares of the  Company's
common  stock  were  first  registered  under  Section  12(g) of the  Securities
Exchange  Act of  1934,  as  amended  (the  "1934  Act").  Such  date is  hereby
designated  as the  Effective  Date of the Plan. 

     C. This Plan  shall  serve as the  successor  to the  Company's  1990 Stock
Option Plan (the "1990 Plan"),  and no further option grants shall be made under
the 1990 Plan  from and  after the  Effective  Date of this  Plan.  All  options
outstanding  under the 1990 Plan on such Effective Date are hereby  incorporated
into this Plan and shall  accordingly  be treated as  outstanding  options under
this Plan. However, each outstanding option so incorporated shall continue to be
governed solely by the express terms and conditions of the instrument evidencing
such grant, and no provision of this Plan shall be deemed to affect or otherwise
modify the rights or  obligations  of the holders of such  incorporated  options
with  respect  to their  acquisition  of shares of the  Company's  common  stock
thereunder  or their  exercise  of any  outstanding  stock  appreciation  rights
thereunder.  

     D. For purposes of the Plan, the following  provisions  shall be applicable
in  determining  the parent and  subsidiary  corporations  of the  Company:  

          Any  corporation  (other than the  Company)  in an  unbroken  chain of
     corporations  ending with the Company shall be considered to be a parent of
     the Company,  provided each such  corporation  in the unbroken chain (other
     than the Company) owns, at the time of the determination,  stock possessing
     fifty  percent  (50%) or more of the  total  combined  voting  power of all
     classes of stock in one of the other corporations in such chain.


<PAGE>

          Each  corporation  (other than the  Company)  in an unbroken  chain of
     corporations  beginning  with  the  Company  shall  be  considered  to be a
     subsidiary of the Company,  provided each such corporation  (other than the
     last  corporation)  in  the  unbroken  chain  owns,  at  the  time  of  the
     determination,  stock  possessing  fifty percent (50%) or more of the total
     combined  voting  power  of all  classes  of  stock  in  one  of the  other
     corporations in such chain.

     E. All share figures in this March 15, 1999 restatement of the Plan reflect
the 20-for-1  reverse split of the Common Stock authorized by the Board on March
15,  1999,  subject to  stockholder  approval  at the 1999  Annual  Stockholders
Meeting.

II.   STRUCTURE OF THE PLAN

     A. Stock Programs.  The Plan shall be divided into two separate components:
the  Discretionary  Option  Grant  Program  specified  in  Article  Two  and the
Automatic   Option  Grant  Program   specified  in  Article  Three.   Under  the
Discretionary Option Grant Program,  eligible individuals may, at the discretion
of the Plan Administrator, be granted options to purchase shares of Common Stock
in accordance  with the  provisions of Article Two.  Under the Automatic  Option
Grant Program,  certain non-employee members of the Company's Board of Directors
(the "Board") will at periodic  intervals  automatically  receive special option
grants to purchase  shares of Common Stock in accordance  with the provisions of
Article Three.

     B. General Provisions.  Unless the context clearly indicates otherwise, the
provisions  of  Articles  One and  Four of the  Plan  shall  apply  to both  the
Discretionary  Option Grant Program and the  Automatic  Option Grant Program and
shall  accordingly  govern the interests of all individuals under the Plan. 

III.  ADMINISTRATION OF THE PLAN

     A. The  Discretionary  Option  Grant  Program  shall be  administered  by a
committee  ("Committee") of two (2) or more non-employee Board members appointed
by the Board.  Members of the  Committee  shall serve for such period of time as
the Board may  determine  and shall be  subject  to  removal by the Board at any
time.

     B. The Committee as Plan Administrator  shall have full power and authority
(subject  to the express  provisions  of the Plan) to  establish  such rules and
regulations  as it may deem  appropriate  for the proper  administration  of the
Discretionary  Option Grant Program and to make such  determinations  under, and
issue  such   interpretations  of,  the  provisions  of  such  program  and  any
outstanding  option grants as it may deem  necessary or advisable.  Decisions of
the Plan  Administrator  shall be final and  binding on all  parties who have an
interest in the  Discretionary  Option Grant Program or any  outstanding  option
thereunder.  

     C.   Administration   of  the  Automatic  Option  Grant  Program  shall  be
self-executing  in accordance  with the express terms and  conditions of Article
Three, and the Committee as Plan  Administrator  shall exercise no discretionary
functions  with  respect to option  grants made  pursuant to that  program.  



                                       2
<PAGE>

IV.   OPTION GRANTS

     A. The persons  eligible to participate in the  Discretionary  Option Grant
Program under Article Two of the Plan shall be limited to the following:

          (i) officers and other key  employees of the Company (or its parent or
          subsidiary  corporations)  who render services which contribute to the
          management, growth and financial success of the Company (or its parent
          or subsidiary corporations);

          (ii) non-employee  members of the Board; 

          (iii) non-employee  members of the board of directors of any parent or
          subsidiary   corporation;   and  

          (iv) those  consultants  or other  independent  advisors  who  provide
          valuable  services  to  the  Company  (or  its  parent  or  subsidiary
          corporations).  B. The Plan Administrator shall have full authority to
          determine the eligible  individuals  who are to receive  option grants
          under the Discretionary  Option Grant Program, the number of shares to
          be covered by each such  grant,  the status of the  granted  option as
          either an incentive stock option ("Incentive  Option") which satisfies
          the  requirements  of Section 422 of the  Internal  Revenue  Code or a
          non-statutory option not intended to meet such requirements,  the time
          or times at which each granted option is to become exercisable and the
          maximum term for which the option may remain outstanding.

V.    STOCK SUBJECT TO THE PLAN

     A. Shares of the  Company's  common  stock (the  "Common  Stock")  shall be
available  for  issuance  under  the Plan and  shall be drawn  from  either  the
Company's  authorized  but unissued  shares of Common  Stock or from  reacquired
shares of Common Stock,  including shares repurchased by the Company on the open
market.  The maximum  number of shares of Common  Stock which may be issued over
the  term of the  Plan  shall  not  exceed  7,000,000  shares  (1),  subject  to
adjustment  from time to time in accordance  with the provisions of Paragraphs B
and E of this Section V. Such authorized  share reserve includes the increase of
6,689,167  shares  authorized  by the  Board  on  March  15,  1999,  subject  to
stockholder approval at the 1999 Annual Stockholders  Meeting. To the extent one
or more

- -----------------
(1)Such share reserve reflects (i) the 1-for-3 reverse stock split of the Common
   Stock  effected  in  connection  with the  reincorporation  of the Company in
   Delaware and the  associated  exchange of three (3) shares of the  California
   corporation's  common stock for one (1) share of the  Delaware  corporation's
   common stock on January 25, 1993,  (ii) the 6,689,167  share  increase to the
   Plan  authorized  by the  Board on March 15,  1999,  subject  to  stockholder
   approval at the 1999 Annual  Meeting and (iii) the 20-for-1  reverse split of
   the  Common  Stock,  authorized  by the Board on March 15,  1999,  subject to
   stockholder approval at the 1999 Annual Meeting.

                                       3
<PAGE>

outstanding options under the 1990 Plan which  have been incorporated  into this
Plan are subsequently  exercised,  the number of shares  issued with respect to 
each such option shall reduce, on a share-for-share  basis, the number of shares
available for issuance under this Plan.

     B. On February 1, 2000, the number of shares of Common Stock issuable under
the Plan shall automatically increase by that number of shares which, when added
to the number of shares subject to then  outstanding  options under the Plan and
the  number  of  shares  available  for  future  option  grant  under  the  Plan
immediately  prior to such  increase,  will equal the  lesser of (a)  25,000,000
shares or (b) twenty percent (20%) of the sum of (i) the number of voting shares
of the Company's  capital stock outstanding at that time plus (ii) the number of
shares of Common Stock  subject to the then  outstanding  options under the Plan
plus (iii) the number of shares available for future option grant under the Plan
(after taking such increase into account). In addition,  the share reserve under
the Plan shall  automatically  increase on the first trading day of January each
calendar year, beginning with calendar year 2001 and continuing through calendar
year 2008, by an amount equal to four percent (4%) of the total number of shares
of Common Stock outstanding on the last trading day of the immediately preceding
calendar year, but in no event will any such annual  increase  exceed the lesser
of (a) 5,000,000 shares of Common Stock or (b) that number of additional  shares
of Common Stock needed so that the number of shares  available  for future grant
under the Plan (after taking that annual increase into account) will, when added
to the number of shares subject to the then  outstanding  options,  equal twenty
percent  (20%) of the sum of (i) the  number of voting  shares of the  Company's
capital stock  outstanding at that time plus (ii) the number of shares of Common
Stock  subject  to the then  outstanding  options  under the Plan plus (iii) the
number of shares of Common  Stock  available  for future  option grant under the
Plan.  

     C. Subject to stockholder approval at the 1999 Annual Stockholders Meeting,
the  maximum  number  of shares  of  Common  Stock for which any one  individual
participating   in  the  Plan  may  be  granted  stock  options  and  separately
exercisable stock  appreciation  rights shall be limited to 5,000,000 shares per
calendar  year,  beginning  with the 1999 calendar  year,  rather than the prior
limitation of 125,000 shares  (2,500,000  shares pre-spilt) per calendar year(2)
(excluding  any stock  options or stock  appreciation  rights  granted  prior to
December 31, 1993).

     D.  Should  one or more  outstanding  options  under  this Plan  (including
outstanding  options under the 1990 Plan  incorporated into this Plan) expire or
terminate  for any  reason  prior to  exercise  in full  (including  any  option
cancelled in accordance with the  cancellation-regrant  provisions of Section IV
of Article  Two of the Plan),  then the  shares  subject to the  portion of each
option not so exercised shall be available for subsequent option grant under the
Plan. In addition,  any unvested  shares issued under the Plan and  subsequently
repurchased by the Company at the original  exercise price per share pursuant to
the Company's repurchase rights under the Plan shall be added back to the number
of  shares  of  Common  Stock  reserved  for  issuance  under the Plan and shall
accordingly be available for reissuance  through one or more  subsequent  option
grants under the Plan. However,  shares subject to any option or portion thereof

- -----------------
(2)The increase in this limitation from 125,000 (pre-split  2,500,000) shares to
   5,000,000  shares per calendar year was  authorized by the Board on March 15,
   1999, subject to stockholder approval at the 1999 Annual Meeting.



                                       4
<PAGE>

surrendered or cancelled in accordance  with Section V of Article Two or Section
III of  Article  Three  shall  reduce on a  share-for-share  basis the number of
shares of Common Stock available for subsequent option grants under the Plan. In
addition,  should the  exercise  price of an  outstanding  option under the Plan
(including  any option  incorporated  from the 1990 Plan) be paid with shares of
Common Stock or should shares of Common Stock otherwise  issuable under the Plan
be withheld by the Company in satisfaction of the withholding  taxes incurred in
connection  with the exercise of an outstanding  option under the Plan, then the
number of shares of Common Stock  available for issuance under the Plan shall be
reduced by the gross number of shares for which the option is exercised, and not
by the net  number  of  shares of Common  Stock  actually  issued to the  option
holder.  

     E. In the event any change is made to the Common Stock  issuable  under the
Plan by reason of any stock split, stock dividend, recapitalization, combination
of shares,  exchange of shares or other change affecting the outstanding  Common
Stock  as  a  class  without  the  Company's  receipt  of  consideration,   then
appropriate  adjustments shall be made to (i) the maximum number and/or class of
securities  issuable  under the Plan,  (ii) the maximum  number  and/or class of
securities for which any one individual participating in the Plan may be granted
stock options and separately  exercisable stock appreciation rights per calendar
year,  (iii) the number and/or class of securities  for which  automatic  option
grants are to be subsequently made to each newly-elected  Board member under the
Automatic  Option Grant Program,  (iv) the number and/or class of securities and
price per  share in effect  under  each  option  outstanding  under  either  the
Discretionary Option Grant or Automatic Option Grant Program under the Plan, (v)
the number and/or class of  securities  and price per share in effect under each
outstanding  option  incorporated into this Plan from the 1990 Plan and (vi) the
maximum  number  and/or  class of  securities  by which the share  reserve is to
increase on February 1, 2000 and each  subsequent  calendar year pursuant to the
automatic  share  increase  provisions  of Section V.B of this Article One. Such
adjustments  to the  outstanding  options are to be  effected in a manner  which
shall  preclude the  enlargement  or dilution of rights and benefits  under such
options.  The adjustments  determined by the Plan Administrator  shall be final,
binding and conclusive. 



                                       5
<PAGE>



                                   ARTICLE TWO
                       DISCRETIONARY OPTION GRANT PROGRAM

I.   TERMS AND CONDITIONS OF OPTIONS

     Options granted pursuant to the Discretionary Option Grant Program shall be
authorized  by  action  of  the  Plan   Administrator   and  may,  at  the  Plan
Administrator's   discretion,  be  either  Incentive  Options  or  non-statutory
options.  Individuals  who are not  Employees  of the  Company  or its parent or
subsidiary  corporations may only be granted non-statutory options. Each granted
option shall be evidenced by one or more instruments in the form approved by the
Plan Administrator;  provided,  however,  that each such instrument shall comply
with the terms and conditions  specified  below.  Each instrument  evidencing an
Incentive Option shall, in addition,  be subject to the applicable provisions of
Section II of this Article Two.

     A. Option Price.

          (1)  The  option   price  per  share   shall  be  fixed  by  the  Plan
Administrator in accordance with the following provisions:

               (i) The option price per share of the Common Stock  subject to an
Incentive  Option  shall in no event be less than one hundred  percent (100%) of
the fair  market  value of such  Common  Stock on the grant date.

               (ii) The option price per share of the Common Stock  subject to a
non-statutory stock option shall be determined   by  the  Plan Administrator in 
its sole  discretion and may  be less than, equal to or greater  than the fair 
market  value of such Common Stock on the grant date. 

          (2)  The option price shall become  immediately  due upon exercise of
the option  and, subject to the provisions of Section VI of this Article Two and
the instrument evidencing the grant,  shall be payable in one of the following 
alternative forms specified below:

               - full payment in cash or check drawn to the Company's order;

               - full payment in shares of Common Stock held by the optionee for
               the requisite period necessary to avoid a charge to the Company's
               earnings  for  financial  reporting  purposes  and valued at fair
               market  value  on the  Exercise  Date (as  such  term is  defined
               below);

               - full payment in a combination  of shares of Common Stock of the
               Company held by the optionee for the requisite  period  necessary
               to  avoid  a  charge  to the  Company's  earnings  for  financial
               reporting  purposes  and  valued  at  fair  market  value  on the
               Exercise Date and cash or check drawn to the Company's order; or


                                       6
<PAGE>

               - full  payment  through  a  broker-dealer  sale  and  remittance
               procedure  pursuant  to which  the  optionee  (I)  shall  provide
               irrevocable  instructions to a Company-designated  brokerage firm
               to effect the immediate sale of the purchased shares and remit to
               the Company, out of the sale proceeds available on the settlement
               date,  sufficient  funds  to cover  the  aggregate  option  price
               payable for the purchased shares plus all applicable  Federal and
               State income and employment  taxes required to be withheld by the
               Company in  connection  with such purchase and (II) shall provide
               directives  to the  Company to deliver the  certificates  for the
               purchased  shares  directly  to such  brokerage  firm in order to
               complete the sale transaction.

           For purposes of this subparagraph (2), the Exercise Date shall be the
date on which written notice of the option exercise is delivered to the Company.
Except to the extent the sale and remittance procedure is utilized in connection
with the exercise of the option,  payment of the option price for the  purchased
shares must accompany such notice.

          (3) The  fair  market  value  per  share  of  Common  Stock  shall  be
determined in accordance with the following provisions:

               - If the Common  Stock is not at the time  listed or  admitted to
               trading  on any  national  stock  exchange  but is  traded on the
               Nasdaq  National  Market,  the  fair  market  value  shall be the
               closing selling price per share on the date in question,  as such
               price is  reported  by the  National  Association  of  Securities
               Dealers on the Nasdaq National Market or any successor system. If
               there is no reported  closing  selling price for the Common Stock
               on the date in question,  then the closing  selling  price on the
               last  preceding  date for which such  quotation  exists  shall be
               determinative of fair market value.

               - If the  Common  Stock  is at the time  listed  or  admitted  to
               trading on any  national  stock  exchange,  then the fair  market
               value shall be the closing selling price per share on the date in
               question on the exchange  determined by the Plan Administrator to
               be the  primary  market  for the Common  Stock,  as such price is
               officially  quoted in the composite tape of  transactions on such
               exchange.  If there is no reported  sale of Common  Stock on such
               exchange  on the date in  question,  then the fair  market  value
               shall be the closing  selling  price on the  exchange on the last
               preceding date for which such quotation exists.

     B.  Term  and  Exercise  of  Options.   Each  option   granted  under  this
Discretionary  Option Grant Program shall be  exercisable  at such time or times
and during such period as is determined by the Plan  Administrator and set forth
in the instrument  evidencing the grant. No such option,  however,  shall have a
maximum term in excess of ten (10) years from the grant date.



                                       7
<PAGE>

     C.Limited  Transferability of Options. During the lifetime of the optionee,
Incentive  Options  shall be  exercisable  only by the optionee and shall not be
assignable  or  transferable  other than by will or by the laws of  descent  and
distribution following the optionee's death. However, non-statutory options may,
in connection  with the optionee's  estate plan, be assigned in whole or in part
during  the  optionee's  lifetime  to  one or  more  members  of the  optionee's
immediate  family  or to a trust  established  exclusively  for one or more such
family  members.  The  assigned  portion may only be  exercised by the person or
persons  who  acquire a  proprietary  interest  in the  option  pursuant  to the
assignment.  The terms  applicable to the assigned  portion shall be the same as
those in effect for the option immediately prior to such assignment and shall be
set forth in such documents issued to the assignee as the Plan Administrator may
deem appropriate. 

     D. Termination of Service.

          (1)  The  following   provisions  shall  govern  the  exercise  period
applicable to any  outstanding  options held by the optionee at the time of
cessation of Service or death.

               - Should an  optionee  cease  Service  for any reason  (including
               death or permanent  disability as defined in Section  22(e)(3) of
               the Internal  Revenue Code) while holding one or more outstanding
               options  under this Article Two, then none of those options shall
               (except to the extent otherwise provided pursuant to subparagraph
               D.(3)  below)  remain  exercisable  for  more  than a  thirty-six
               (36)-month  period (or such shorter period determined by the Plan
               Administrator  and set  forth in the  instrument  evidencing  the
               grant) measured from the date of such cessation of Service.

               - Any option  held by the  optionee  under this  Article  Two and
               exercisable  in whole or in part on the date of his/her death may
               be subsequently  exercised by the personal  representative of the
               optionee's  estate or by the person or persons to whom the option
               is transferred  pursuant to the optionee's  will or in accordance
               with the laws of descent and distribution. Any exercise, however,
               must occur prior to the earlier of (i) the third  anniversary  of
               the date of the optionee's death or (ii) the specified expiration
               date of the  option  term.  Upon the  occurrence  of the  earlier
               event, the option shall terminate and cease to be outstanding.

               - Under no  circumstances,  however,  shall  any such  option  be
               exercisable  after the  specified  expiration  date of the option
               term.

               - During the applicable  post-Service exercise period, the option
               may not be exercised in the aggregate for more than the number of
               shares  (if any) in which the  optionee  is vested at the time of
               his/her cessation of Service.  Upon the expiration of the limited
               post-Service  exercise  period or (if earlier) upon the specified
               expiration  date of the  option  term,  each  such  option  shall
               terminate and cease to be outstanding  with respect to any vested
               shares  for which the option has not  otherwise  been  exercised.
               However,  each outstanding option shall immediately terminate and



                                       8
<PAGE>

               cease to be outstanding,  at the time of the optionee's cessation
               of  Service,  with  respect to any shares for which the option is
               not otherwise at that time  exercisable  or in which the optionee
               is not otherwise vested.

               - Should (i) the optionee's  Service be terminated for misconduct
               (including,  but not limited to, any act of  dishonesty,  willful
               misconduct,  fraud or embezzlement) or (ii) the optionee make any
               unauthorized  use or disclosure of  confidential  information  or
               trade  secrets  of  the  Company  or  its  parent  or  subsidiary
               corporations, then in any such event all outstanding options held
               by  the  optionee   under  this   Article  Two  shall   terminate
               immediately and cease to be outstanding.

          (2) The Plan Administrator shall have complete discretion, exercisable
either at the time the option is granted or at any time while the option remains
outstanding,  to permit one or more  options  held by the optionee under this  
Article Two to be  exercised,  during the limited  post-Service exercise period 
applicable  under  subparagraph  (1) above,  not only with respect to the number
of vested  shares of Common Stock for which each such option is exercisable  at 
the time of the  optionee's  cessation of Service but also with respect to one 
or more  subsequent  installments in which the optionee would otherwise have 
vested had he/she continued in Service.

          (3) The Plan Administrator  shall  also have full power and  authority
to extend the period of time for  which  the  option  is to  remain  exercisable
following the  optionee's  cessation of Service or death from the limited period
in effect under  subparagraph  (1) above to such  greater  period of time as the
Plan  Administrator  shall deem appropriate.  In no event,  however,  shall such
option be exercisable  after the specified  expiration  date of the option term.


          (4) For purposes of the foregoing  provisions of this Section I.D (and
for all other purposes under the Discretionary Option Grant Program): 

               - The optionee shall (except to the extent otherwise specifically
               provided  in  the  applicable  stock  option  or  stock  purchase
               agreement)  be deemed to remain in the Service of the Company for
               so long as such individual  renders  services on a periodic basis
               to the Company (or any parent or subsidiary  corporation)  in the
               capacity of an Employee, a non-employee member of the Board or an
               independent consultant or advisor.

               - The optionee  shall be considered to be an Employee for so long
               as he or she  remains in the employ of the Company or one or more
               parent or  subsidiary  corporations,  subject to the  control and
               direction  of the  employer  entity not only as to the work to be
               performed but also as to the manner and method of performance.

     E. Stockholder  Rights.  An optionee shall have no stockholder  rights with
respect to any shares  covered by the option  until such  individual  shall have
exercised the option and paid the option price for the purchased shares.



                                       9
<PAGE>

     F. Repurchase Rights. The shares of Common Stock acquired upon the exercise
of any Article Two option grant may be subject to  repurchase  by the Company in
accordance with the following provisions:  

          (i) The Plan Administrator  shall have the discretion to authorize the
     issuance of unvested  shares of Common Stock under this Article Two. Should
     the optionee cease Service while holding such unvested shares,  the Company
     shall have the right to repurchase any or all of those  unvested  shares at
     the option price paid per share.  The terms and conditions  upon which such
     repurchase  right shall be exercisable  (including the period and procedure
     for exercise and the appropriate vesting schedule for the purchased shares)
     shall  be  established  by the  Plan  Administrator  and set  forth  in the
     instrument evidencing such repurchase right.

          (ii) All of the  Company's  outstanding  repurchase  rights under this
     Article Two shall automatically  terminate,  and all shares subject to such
     terminated  rights shall  immediately  vest in full, upon the occurrence of
     any Corporate  Transaction under Section III of this Article Two, except to
     the extent:  (i) any such  repurchase  right is  expressly  assigned to the
     successor  corporation (or parent thereof) in connection with the Corporate
     Transaction  or  (ii)  such  accelerated  vesting  is  precluded  by  other
     limitations  imposed by the Plan  Administrator  at the time the repurchase
     right is issued.  

          (iii) The Plan Administrator  shall have the discretionary  authority,
     exercisable either before or after the optionee's  cessation of Service, to
     cancel the Company's  outstanding  repurchase rights with respect to one or
     more  shares   purchased  or   purchasable   by  the  optionee  under  this
     Discretionary  Option Grant Program and thereby  accelerate  the vesting of
     such shares in whole or in part at any time. 

II. INCENTIVE OPTIONS

     The  terms  and  conditions  specified  below  shall be  applicable  to all
Incentive Options granted under this Article Two.  Incentive Options may only be
granted to  individuals  who are  Employees  of the Company.  Options  which are
specifically  designated as  "non-statutory"  options when issued under the Plan
shall not be subject to such terms and conditions.



                                       10
<PAGE>

     A. Dollar Limitation. The aggregate fair market value (determined as of the
respective  date or dates of  grant) of the  Common  Stock for which one or more
options  granted to any Employee after December 31, 1986 under this Plan (or any
other option plan of the Company or its parent or subsidiary  corporations)  may
for the first time become  exercisable  as  incentive  stock  options  under the
Federal  tax laws during any one  calendar  year shall not exceed the sum of One
Hundred Thousand Dollars ($100,000). To the extent the Employee holds two (2) or
more such  options  which  become  exercisable  for the  first  time in the same
calendar year, the foregoing limitation on the exercisability of such options as
incentive stock options under the Federal tax laws shall be applied on the basis
of the order in which such options are  granted.  Should the number of shares of
Common Stock for which any  Incentive  Option first becomes  exercisable  in any
calendar  year exceed the  applicable  One Hundred  Thousand  Dollar  ($100,000)
limitation, then that option may nevertheless be exercised in that calendar year
for the excess number of shares as a non-statutory  option under the Federal tax
laws.

     B. 10%  Stockholder.  If any  individual  to whom an  Incentive  Option  is
granted  is the  owner of stock  (as  determined  under  Section  424(d)  of the
Internal  Revenue  Code)  possessing  ten  percent  (10%)  or more of the  total
combined  voting  power of all classes of stock of the Company or any one of its
parent or subsidiary corporations,  then the option price per share shall not be
less than one hundred and ten percent  (110%) of the fair market value per share
of Common Stock on the grant date, and the option term shall not exceed five (5)
years,  measured  from the grant  date.  Except  as  modified  by the  preceding
provisions  of this Section II, the  provisions of Articles One, Two and Four of
the Plan shall apply to all Incentive Options granted hereunder.

III.  CORPORATE TRANSACTIONS/CHANGES IN CONTROL

     A. In the event of any of the following  stockholder-approved  transactions
(a "Corporate Transaction") to which the Company is a party:

          (i) a  merger  or  consolidation  in  which  the  Company  is not  the
     surviving  entity,  except for a transaction the principal purpose of which
     is to change the State of the Company's incorporation,

          (ii) the sale,  transfer or other  disposition of all or substantially
     all of the assets of the Company in complete  liquidation or dissolution of
     the  Company,  or 

          (iii) any reverse merger in which the Company is the surviving  entity
     but in which  securities  possessing  more than fifty  percent (50%) of the
     total  combined  voting power of the Company's  outstanding  securities are
     transferred  to  person  or  persons  different  from  those  who held such
     securities immediately prior to such merger,



                                       11
<PAGE>

     then  each option  which  is  at  the time  outstanding  under this Article
     Two  shall  automatically  accelerate  so  that  each  such  option  shall,
     immediately  prior  to the  specified  effective  date  for  the  Corporate
     Transaction,  become fully  exercisable with respect to the total number of
     shares  of  Common  Stock at the time  subject  to such  option  and may be
     exercised for all or any portion of such shares.  However,  an  outstanding
     option under this Article Two shall not so accelerate if and to the extent:
     (i) such option is, in connection with the Corporate Transaction, either to
     be assumed by the successor corporation or parent thereof or to be replaced
     with a  comparable  option to purchase  shares of the capital  stock of the
     successor corporation or parent thereof, (ii) such option is to be replaced
     with a cash incentive program of the successor  corporation which preserves
     the option  spread  existing at the time of the Corporate  Transaction  and
     provides for subsequent payout in accordance with the same vesting schedule
     applicable  to such  option,  or (iii) the  acceleration  of such option is
     subject to other limitations  imposed by the Plan Administrator at the time
     of the option grant. The determination of option comparability under clause
     (i) above shall be made by the Plan  Administrator,  and its  determination
     shall be final, binding and conclusive.

     B. Immediately following the consummation of the Corporate Transaction, all
outstanding  options  under this  Article  Two shall  terminate  and cease to be
outstanding,  except to the extent  assumed by the successor  corporation or its
parent company.

     C. Each  outstanding  option  under  this  Article  Two which is assumed in
connection with the Corporate  Transaction or is otherwise to continue in effect
shall be appropriately  adjusted,  immediately after such Corporate Transaction,
to apply and pertain to the number and class of securities which would have been
issued to the option holder, in consummation of such Corporate Transaction,  had
such  person   exercised  the  option   immediately   prior  to  such  Corporate
Transaction.  Appropriate  adjustments  shall also be made to the  option  price
payable  per  share,  provided  the  aggregate  option  price  payable  for such
securities  shall  remain  the  same.  In  addition,  the  class  and  number of
securities  available  for issuance  under the Plan on both an aggregate and per
participant basis following the consummation of the Corporate  Transaction shall
be appropriately  adjusted. 

     D. The grant of options  under this  Article Two shall in no way affect the
right of the Company to adjust,  reclassify,  reorganize or otherwise change its
capital or business structure or to merge, consolidate,  dissolve,  liquidate or
sell or  transfer  all or any  part of its  business  or  assets.  

     E.  The  Plan  Administrator   shall  have  the  discretionary   authority,
exercisable  either at the time the  option is  granted or at any time while the
option is outstanding,  to provide for the automatic acceleration of one or more
outstanding  options under this Article Two (and the  termination of one or more
of the Company's outstanding  repurchase rights under this Article Two) upon the
occurrence of the Change in Control. The Plan Administrator shall also have full
power  and  authority  to  condition  any  such  option  acceleration  (and  the
termination  of  any   outstanding   repurchase   rights)  upon  the  subsequent
termination of the optionee's  Service within a specified  period  following the
Change in  Control.  

     F. For purposes of this Section III, a Change in Control shall be deemed to
occur in the event:  



                                       12
<PAGE>

          (i) any person or related group of persons  (other than the Company or
     a person that directly or  indirectly  controls,  is  controlled  by, or is
     under common  control with,  the Company)  directly or indirectly  acquires
     beneficial  ownership (within the meaning of Rule 13d-3 of the 1934 Act) of
     securities  possessing  more than fifty percent (50%) of the total combined
     voting power of the Company's  outstanding  securities pursuant to a tender
     or exchange offer made directly to the Company's stockholders; or

          (ii) there is a change in the  composition  of the Board over a period
     of twenty-four (24) consecutive  months or less such that a majority of the
     Board  members  ceases,  by reason of one or more  proxy  contests  for the
     election of Board members,  to be comprised of  individuals  who either (A)
     have been Board members  continuously since the beginning of such period or
     (B) have been elected or nominated  for  election as Board  members  during
     such period by at least a majority of the Board members described in clause
     (A) who were still in office at the time such  election or  nomination  was
     approved by the Board.  

     G. Any options  accelerated in connection  with the Change in Control shall
remain fully  exercisable  until the  expiration  or sooner  termination  of the
option term.

     H. The exercisability as incentive stock options under the Federal tax laws
of any options accelerated under this Section III in connection with a Corporate
Transaction or Change in Control shall remain  subject to the dollar  limitation
of Section II of this Article Two. 

IV. CANCELLATION AND REGRANT OF OPTIONS

     The Plan Administrator  shall have the authority to effect, at any time and
from time to time, with the consent of the affected optionees,  the cancellation
of any or all outstanding options under this Article Two (including  outstanding
options  under  the 1990  Plan  incorporated  into  this  Plan)  and to grant in
substitution  new options under the Plan covering the same or different  numbers
of shares of Common  Stock but with an option  price per share based on the fair
market value of the Common Stock on the date of the new grant.

V.    STOCK APPRECIATION RIGHTS

     A. Provided and only if the Plan Administrator determines in its discretion
to implement the stock  appreciation  right provisions of this Section V, one or
more  optionees  may be  granted  the  right,  exercisable  upon such  terms and
conditions as the Plan Administrator may establish,  to surrender all or part of
an unexercised option under this Article Two in exchange for a distribution from
the Company in an amount  equal to the excess of (i) the fair  market  value (on
the option  surrender  date) of the number of shares in which the optionee is at
the time vested under the surrendered  option (or surrendered  portion  thereof)
over (ii) the aggregate option price payable for such vested shares.



                                       13
<PAGE>

     B. No surrender  of an option  shall be  effective  hereunder  unless it is
approved by the Plan  Administrator.  If the surrender is so approved,  then the
distribution to which the optionee shall accordingly  become entitled under this
Section V may be made in shares of Common  Stock  valued at fair market value on
the option  surrender  date, in cash, or partly in shares and partly in cash, as
the Plan Administrator shall in its sole discretion deem appropriate.  

     C. If the  surrender  of an option is rejected  by the Plan  Administrator,
then the  optionee  shall  retain  whatever  rights the  optionee  had under the
surrendered option (or surrendered portion thereof) on the option surrender date
and may  exercise  such  rights  at any time  prior to the later of (i) five (5)
business days after the receipt of the rejection  notice or (ii) the last day on
which the option is otherwise  exercisable  in accordance  with the terms of the
instrument  evidencing such option, but in no event may such rights be exercised
more than ten (10)  years  after the date of the  option  grant.  

     D. One or more officers of the Company  subject to the  short-swing  profit
restrictions  of the Federal  securities  laws may, in the Plan  Administrator's
sole  discretion,  be granted limited stock  appreciation  rights in tandem with
their  outstanding  options  under the Plan.  Upon the  occurrence  of a Hostile
Take-Over  effected at any time when the Company's  outstanding  Common Stock is
registered  under Section 12(g) of the 1934 Act,  each  outstanding  option with
such a limited stock appreciation right shall automatically be cancelled, to the
extent such option is at the time exercisable for fully-vested  shares of Common
Stock. The optionee shall in return be entitled to a cash  distribution from the
Company  in an  amount  equal to the  excess of (i) the  Take-Over  Price of the
vested  shares of Common Stock at the time subject to the  cancelled  option (or
cancelled portion of such option) over (ii) the aggregate exercise price payable
for such  shares.  The cash  distribution  shall  be made  within  five (5) days
following the  consummation  of the Hostile  Take-Over.  The Plan  Administrator
shall  pre-approve,  at the time the limited  right is granted,  the  subsequent
exercise  of that  right in  accordance  with the  terms  of the  grant  and the
provisions of this Section V.D. No additional approval of the Plan Administrator
or the Board shall be required at the time of the actual option cancellation and
cash  distribution.  The balance of the option (if any) shall continue to remain
outstanding  and  become  exercisable  in  accordance  with  the  terms  of  the
instrument  evidencing such grant. 

     E. For  purposes of Section  V.D,  the  following  definitions  shall be in
effect: 

          A Hostile  Take-Over  shall be deemed to occur in the event any person
     or  related  group of persons  (other  than the  Company  or a person  that
     directly or  indirectly  controls,  is  controlled  by, or is under  common
     control  with,  the Company)  acquires  directly or  indirectly  beneficial
     ownership  (within the meaning of Rule 13d-3 of the 1934 Act) of securities
     possessing more than fifty percent (50%) of the total combined voting power
     of the Company's  outstanding  securities  pursuant to a tender or exchange
     offer made directly to the Company's  stockholders which the Board does not
     recommend such stockholders to accept.



                                       14
<PAGE>

          The  Take-Over  Price  per  share  shall be  deemed to be equal to the
     greater  of (a) the fair  market  value per  share of  Common  Stock on the
     option   cancellation  date,  as  determined   pursuant  to  the  valuation
     provisions  of Section  I.A.(3) of this  Article  Two,  or (b) the  highest
     reported  price per share of Common  Stock paid in  effecting  such Hostile
     Take-Over.  However,  if the cancelled option is an Incentive  Option,  the
     Take-Over Price shall not exceed the clause (a) price per share.

     F. The  shares  of  Common  Stock  subject  to any  option  surrendered  or
cancelled for an appreciation  distribution pursuant to this Section V shall not
be available for subsequent option grant under the Plan.

VI.   LOANS OR INSTALLMENT PAYMENTS

     The  Plan  Administrator  may,  in  its  discretion,  assist  any  optionee
(including  an optionee  who is an officer or  director  of the  Company) in the
exercise of one or more options granted to such optionee under this Article Two,
including the  satisfaction  of any Federal and State income and  employment tax
obligations  arising therefrom,  by (i) authorizing the extension of a loan from
the Company to such optionee or (ii)  permitting  the optionee to pay the option
price for the purchased Common Stock in installments over a period of years. The
terms of any loan or installment  method of payment (including the interest rate
and  terms of  repayment)  will be upon  such  terms  as the Plan  Administrator
specifies in the  applicable  option  agreement or otherwise  deems  appropriate
under the circumstances.  Loans and installment  payments may be granted with or
without  security or collateral.  However,  the maximum credit  available to the
optionee  shall not  exceed  the sum of (i) the  aggregate  option  price of the
purchased  shares  plus (ii) any  Federal and State  income and  employment  tax
liability  incurred  by the  optionee  in  connection  with the  exercise of the
option.


                                       15
<PAGE>

                                  ARTICLE THREE
                         AUTOMATIC OPTION GRANT PROGRAM


           The  provisions  of this  Article  Three  reflect  the changes to the
Automatic  Option  Grant  Program  authorized  by the Board on March  15,  1999,
subject to stockholder approval at the 1999 Annual Meeting.

I.    ELIGIBILITY

     The individuals eligible to receive automatic option grants pursuant to the
provisions  of  this  Article  Three  program  shall  be  limited  to (i)  those
individuals  who are serving as  non-employee  Board members on February 1, 2000
and (ii) those  individuals  who are first elected or appointed as  non-employee
Board members after February 1, 2000,  whether through  appointment by the Board
or election by the Company's stockholders, provided they have not otherwise been
in the prior employ of the Company (or any parent or subsidiary corporation).

II.   TERMS AND CONDITIONS OF AUTOMATIC OPTION GRANTS

     A. Grant Dates. Option grants shall be made under this Article Three on the
dates specified below.  Stockholder  approval of this March 15, 1999 restatement
at the 1999 Annual  Stockholders  Meeting shall constitute  pre-approval of each
option  granted under this Article  Three after the date of that Annual  Meeting
and  the  subsequent  exercise  of each  such  option  in  accordance  with  the
provisions of this Article Three.

          Each  individual  who is serving  as a  non-employee  Board  member on
     February  1, 2000 shall  automatically  be  granted,  at the that  time,  a
     non-statutory  stock  option to  purchase  that  number of shares of Common
     Stock equal to one half of one percent (0.5%) of the total number of voting
     shares of the Company's capital stock outstanding at that time.

               (i)  (iii)Each   individual  who  first  joins  the  Board  as  a
          non-employee  Board member after February 1, 2000 shall  automatically
          be  granted,  upon his or her initial  appointment  or election to the
          Board, a non-statutory  stock option to purchase that number of shares
          of Common  Stock equal to one half of one percent  (0.5%) of the total
          number of voting shares of the Company's  capital stock outstanding on
          February 1, 2000, provided such individual has not previously been the
          Company's employ.

     No other option  grants  shall be made to the  non-employee  Board  members
under this Article Three.  The number of shares subject to the automatic  option
grants to be made to each  newly-elected or appointed  non-employee Board member
shall be subject to periodic adjustment pursuant to the applicable provisions of
Section V.E of Article One.

     B. Exercise  Price.  The exercise price per share of each automatic  option
grant made under this Article Three shall be equal to one hundred percent (100%)
of the fair market value per share of Common Stock on the automatic grant date.



                                       16
<PAGE>

     C. Payment.  

     The  exercise  price  shall  be  payable  in  one of the  alternative forms
specified below:

               (i) full payment in cash or check made  payable to the  Company's
          order; or

               (ii)  full  payment  in  shares  of  Common  Stock  held  for the
          requisite period necessary to avoid a charge to the Company's reported
          earnings and valued at fair market value on the Exercise Date (as such
          term is defined  below);  or 

               (iii) full  payment in a  combination  of shares of Common  Stock
          held for the  requisite  period  necessary  to  avoid a charge  to the
          Company's  reported  earnings  and valued at fair market  value on the
          Exercise  Date and cash or check payable to the  Company's  order;  or
          
               (iv)  full  payment  through  a  sale  and  remittance  procedure
          pursuant  to which the  non-employee  Board  member (I) shall  provide
          irrevocable  instructions  to a  Company-designated  brokerage firm to
          effect the  immediate  sale of the  purchased  shares and remit to the
          Company,  out of the sale proceeds  available on the settlement  date,
          sufficient funds to cover the aggregate exercise price payable for the
          purchased shares and shall (II) concurrently provide directives to the
          Company to deliver the  certificates for the purchased shares directly
          to such brokerage firm in order to complete the sale transaction.  For
          purposes of this  subparagraph  C, the Exercise Date shall be the date
          on which  written  notice of the option  exercise is  delivered to the
          Company,  and the fair market  value per share of Common  Stock on any
          relevant date shall be determined in accordance with the provisions of
          Section  I.A.(3)  of  Article  Two.  Except to the extent the sale and
          remittance  procedure  specified above is utilized for the exercise of
          the option,  payment of the option price for the purchased shares must
          accompany the exercise notice.

     D. Option Term.  Each automatic grant under this Article Three shall have a
maximum term of ten (10) years measured from the automatic grant date.

     E.  Exercisability.  Each automatic grant shall become  exercisable for the
option  shares  in  a  series  of  forty-eight  (48)  successive  equal  monthly
installments upon the optionee's  completion of each month of Board service over
the forty-eight  (48)-month  period measured from the grant date of that option.
The  option  shall not  become  exercisable  for any  additional  option  shares
following the optionee's  cessation of Board service for any reason.  

     F. Limited Transferability of Options.  Options granted under the Automatic
Option Grant  Program may, in  connection  with the  optionee's  estate plan, be
assigned  in whole or in part  during  the  optionee's  lifetime  to one or more
members of the optionee's immediate family or to a trust established exclusively
for one or more such family members.  The assigned portion may only be exercised



                                       17
<PAGE>

by the  person or  persons  who  acquire a  proprietary  interest  in the option
pursuant to the assignment.  The terms  applicable to the assigned portion shall
be the  same as  those  in  effect  for the  option  immediately  prior  to such
assignment  and shall be set forth in such  documents  issued to the assignee as
the Plan  Administrator may deem appropriate.  

     G. Effect of Termination of Board Membership.

          (1)  Should  the  optionee  cease to serve as a Board  member  for any
     reason (other than death) while holding one or more automatic option grants
     under this Article  Three,  then such  optionee  shall have a six (6)-month
     period following the date of such cessation of Board membership in which to
     exercise  each such option for any or all of the shares of Common Stock for
     which the  option is  exercisable  at the time of such  cessation  of Board
     service.  Each such  option  shall  immediately  terminate  and cease to be
     outstanding,  at the time of such cessation of Board service,  with respect
     to  any  shares  for  which  the  option  is not  otherwise  at  that  time
     exercisable.

          (2) Should the optionee die while  serving as a member of the Board or
     within  six  (6)  months  after  cessation  of  Board  service,  then  each
     outstanding  automatic  option  grant held by the  optionee  at the time of
     death may subsequently be exercised, for any or all of the shares of Common
     Stock for which the  option is  exercisable  at the time of the  optionee's
     cessation of Board service (less any option shares  subsequently  purchased
     by the  optionee  prior to death),  by the personal  representative  of the
     optionee's  estate  or by the  person  or  persons  to whom the  option  is
     transferred  pursuant to the optionee's will or in accordance with the laws
     of descent and  distribution.  Any such  exercise  must occur within twelve
     (12) months  after the date of the  optionee's  death.  However,  each such
     automatic  option  grant  shall  immediately  terminate  and  cease  to  be
     outstanding, at the time of the optionee's cessation of Board service, with
     respect to any option shares for which it was not otherwise  exercisable at
     that time.  

          (3) In no event shall any  automatic  option  grant under this Article
     Three remain  exercisable  after the specified  expiration  date of the ten
     (10)-year  option term. Upon the expiration of the applicable  post-service
     exercise  under  subparagraph  1  or 2  above  or  (if  earlier)  upon  the
     expiration of the ten  (10)-year  option term,  the automatic  option grant
     shall terminate and cease to be outstanding for any unexercised  shares for
     which the option was exercisable at the time of the optionee's cessation of
     Board service. 

     H. Stockholder  Rights.  The holder of an automatic option grant under this
Article Three shall have none of the rights of a stockholder with respect to any
shares  subject to such option until such  individual  shall have  exercised the
option and paid the exercise price for the purchased shares.

     I. Remaining  Terms.  The remaining  terms and conditions of each automatic
option grant shall be as set forth in the prototype  Non-statutory  Stock Option
Agreement attached as Exhibit A to the Plan. 



                                       18
<PAGE>

III.  CORPORATE  TRANSACTION/CHANGE IN CONTROL/HOSTILE TAKE-OVER

     A. In the event of any of the following  stockholder-approved  transactions
to which the Company is a party (a "Corporate Transaction"):

          (i) a  merger  or  consolidation  in  which  the  Company  is not  the
     surviving  entity,  except for a transaction the principal purpose of which
     is to change the State of the Company's incorporation,

          (ii) the sale,  transfer or disposition of all or substantially all of
     the assets of the Company in liquidation or dissolution of the Company,  or
    

          (iii) any reverse merger in which the Company is the surviving  entity
     but in which  securities  possessing  more than fifty  percent (50%) of the
     total  combined  voting power of the Company's  outstanding  securities are
     transferred  to  person  or  persons  different  from  those  who held such
     securities  immediately  prior to such merger,  the  exercisability of each
     automatic  option grant at the time  outstanding  under this Article  Three
     shall automatically  accelerate so that each such option shall, immediately
     prior to the specified effective date for the Corporate Transaction, become
     fully  exercisable  with  respect  to the total  number of shares of Common
     Stock at the time  subject to such option and may be  exercised  for all or
     any portion of such shares.  Immediately  following the consummation of the
     Corporate Transaction, all automatic option grants under this Article Three
     shall terminate and cease to be  outstanding,  except to the extent assumed
     by the successor corporation or its parent company.

     B.  In  connection  with  any  Change  in  Control  of  the  Company,   the
exercisability of each automatic option grant at the time outstanding under this
Article  Three shall  automatically  accelerate  so that each such option shall,
immediately  prior to the  specified  effective  date for the Change in Control,
become  fully  exercisable  with respect to the total number of shares of Common
Stock at the time  subject to such  option and may be  exercised  for all or any
portion of such shares at any time prior to the expiration or sooner termination
of the option  term.  For purposes of this  Article  Three,  a Change in Control
shall be deemed to occur in the event:

          (i) any person or related group of persons  (other than the Company or
     a person that directly or  indirectly  controls,  is  controlled  by, or is
     under common  control with,  the Company)  directly or indirectly  acquires
     beneficial  ownership  (within the meaning of Rule 13d-3 of the  Securities
     Exchange Act of 1934, as amended) of securities  possessing more than fifty
     percent  (50%)  of  the  total  combined  voting  power  of  the  Company's
     outstanding securities pursuant to a tender or exchange offer made directly
     to the Company's stockholders; or



                                       19
<PAGE>

          (ii) there is a change in the  composition  of the Board over a period
     of twenty-four (24) consecutive  months or less such that a majority of the
     Board  members  ceases,  by reason of one or more  proxy  contests  for the
     election of Board members,  to be comprised of  individuals  who either (A)
     have been Board members  continuously since the beginning of such period or
     (B) have been elected or nominated  for  election as Board  members  during
     such period by at least a majority of the Board members described in clause
     (A) who were still in office at the time such  election or  nomination  was
     approved by the Board. 

     C. Upon the  occurrence of a Hostile  Take-Over,  each option granted under
this Article Three shall  automatically be cancelled,  and the optionee shall in
return be entitled to a cash distribution from the Company in an amount equal to
the excess of (i) the Take-Over  Price of the shares of Common Stock at the time
subject to the cancelled  option  (whether or not the option is otherwise at the
time exercisable for such shares) over (ii) the aggregate exercise price payable
for such  shares.  Such cash  distribution  shall be paid  within  five (5) days
following the consummation of the Hostile Take-Over. Stockholder approval of the
March  15,  1999  restatement  of the  Plan at the  1999  Annual  Meeting  shall
constitute  pre-approval  of each option  granted  after the date of that Annual
Meeting  with  such an  automatic  cancellation  provision  and  the  subsequent
cancellation  of that option in accordance  with such  provision.  No additional
approval of the Plan Administrator or the Board shall be required at the time of
the actual option cancellation and cash distribution.

     D. For purposes of this Section III, the following  definitions shall be in
effect: 

          A Hostile  Take-Over  shall be deemed to occur in the event any person
     or  related  group of persons  (other  than the  Company  or a person  that
     directly or  indirectly  controls,  is  controlled  by, or is under  common
     control  with,  the Company)  directly or  indirectly  acquires  beneficial
     ownership (within the meaning of Rule 13d-3 of the Securities  Exchange Act
     of 1934, as amended) of securities possessing more than fifty percent (50%)
     of the total combined voting power of the Company's outstanding  securities
     pursuant  to a tender or  exchange  offer made  directly  to the  Company's
     stockholders  which the  Board  does not  recommend  such  stockholders  to
     accept.

          The  Take-Over  Price  per  share  shall be  deemed to be equal to the
     greater  of (a) the fair  market  value per  share of  Common  Stock on the
     option   cancellation  date,  as  determined   pursuant  to  the  valuation
     provisions of Section  I.A.(3) of Article Two, or (b) the highest  reported
     price per share  paid by the  tender  offeror  in  effecting  such  Hostile
     Take-Over.

     E.  The  shares  of  Common  Stock  subject  to each  option  cancelled  in
connection  with the Hostile  Take-Over  shall not be available  for  subsequent
option grant under this Plan.

     F. The automatic option grants  outstanding  under this Article Three shall
in no way affect the right of the Company to adjust,  reclassify,  reorganize or
otherwise  change its capital or business  structure  or to merge,  consolidate,
dissolve,  liquidate  or sell or  transfer  all or any part of its  business  or
assets. 


                                       20
<PAGE>

                                  ARTICLE FOUR
                                  MISCELLANEOUS

I.    AMENDMENT OF THE PLAN AND AWARDS

     The Board has complete and exclusive power and authority to amend or modify
the Plan (or any component thereof) in any or all respects whatsoever.  However,
no such amendment or  modification  shall,  without the consent of the Company's
stockholders, adversely affect rights and obligations with respect to options at
the time outstanding under the Plan. In addition, certain amendments may require
stockholder approval pursuant to applicable laws or regulations.

II.   TAX WITHHOLDING

     The  Company's  obligation  to deliver  shares or cash upon the exercise of
stock  options  or stock  appreciation  rights  granted  under the Plan shall be
subject to the  satisfaction of all applicable  Federal,  State and local income
tax and employment tax withholding requirements.

     The Plan  Administrator  may, in its discretion and in accordance  with the
provisions of this Section II of Article Four and such supplemental rules as the
Plan  Administrator  may  from  time to time  adopt  (including  the  applicable
safe-harbor  provisions  of SEC  Rule  16b-3),  provide  any or all  holders  of
non-statutory  options  under the Plan  (other  than the  automatic  grants made
pursuant  to  Article  Three of the Plan)  with the  right to use  shares of the
Company's Common Stock in satisfaction of all or part of the Federal,  State and
local  income and  employment  withholding  taxes to which such  holders  may be
subject in  connection  with the  exercise of their  options  (the  "Withholding
Taxes").  Such right may be provided to any such option holder in either or both
of the following formats:

          (i) Stock Withholding:  The holder of the non-statutory  option may be
     provided with the election to have the Company withhold, from the shares of
     Common Stock  otherwise  issuable  upon the exercise of such  non-statutory
     option,  a portion of such shares with an aggregate fair market value equal
     to the  percentage of the applicable  Withholding  Taxes (not to exceed one
     hundred percent (100%)) designated by the option holder.

          (ii) Stock Delivery:  The Plan  Administrator  may, in its discretion,
     provide  the  holder  of the  non-statutory  option  with the  election  to
     deliver,  at the time the  non-statutory  option is exercised,  one or more
     shares of Common Stock  already held by such  individual  with an aggregate
     fair market value equal to the percentage of the Withholding Taxes incurred
     in connection  with such option exercise (not to exceed one hundred percent
     (100%)) designated by the option holder. 



                                       21
<PAGE>

III.  EFFECTIVE DATE AND TERM OF PLAN

     The  information  provided  in this  Section  III is based upon a number of
specific  amendments  made to the Plan  since  the  Effective  Date.  Except  as
otherwise  expressly  indicated  below,  none of the share  numbers  reflect the
20-for-1  reverse split of the Common Stock authorized by the Board on March 15,
1999.

     A. The Plan first became  effective on the Effective Date and serves as the
successor to the  Company's  1990 Stock Option Plan.  No further  option  grants
shall be made under the 1990 Plan from and after the Effective Date.

     B. On May 26,  1993,  the Board  amended the Plan to increase the number of
shares issuable thereunder by 1,000,000 shares. The 1,000,000-share increase was
approved by the Company's  stockholders at the 1994 Annual Stockholders Meeting.
On March 28, 1994, the Board further  amended the Plan to impose a limitation on
the maximum number of shares for which any one individual  participating  in the
Plan may be granted stock options and separately  exercisable stock appreciation
rights.  

     C. On February 24, 1995,  the Board amended the Plan to increase the number
of  shares  of  Common  Stock  issuable   thereunder  by  545,000  shares.   The
545,000-share  increase was approved by the Company's  stockholders  at the 1995
Annual Stockholders  Meeting. 

     D. On February 24, 1995, the Board further amended the Plan to increase the
number of shares of Common  Stock for which  automatic  option  grants are to be
made to  continuing  non-employee  Board  members  on the  date  of each  Annual
Stockholders Meeting held after February 24, 1995. The amendment was approved by
the Company's stockholders at the 1995 Annual Stockholders Meeting. 

     E. On August 21, 1995, the Board amended the Plan to extend the eligibility
provisions of the Discretionary  Option Grant Program to all non-employee  Board
members other than those at the time serving on the Committee acting as the Plan
Administrator.  The amendment was approved by the Company's  stockholders at the
1996 Annual  Stockholders  Meeting.  

     F. In January  1996,  the Board  adopted an amendment to the Plan which (i)
increased the number of shares of Common Stock  available for issuance under the
Plan by an additional  450,000  shares and (ii)  increased the maximum number of
shares for which any one  individual may be granted stock options and separately
exercisable stock appreciation  rights over the remaining term of the Plan by an
additional  250,000  shares of Common  Stock.  The amendment was approved by the
Company's  stockholders at the 1996 Annual Stockholders  Meeting. 

     G. In February  1997,  the Board adopted a series of amendments to the Plan
(the "1997 Amendments") which (i) increased the number of shares of Common Stock
available for issuance  under the Plan by an  additional  700,000  shares,  (ii)
increased  the limit on the  maximum  number of shares of the  Company's  common
stock for which any one  individual  may be granted stock options and separately
exercisable  stock  appreciation  rights under the Plan from  500,000  shares to



                                       22
<PAGE>

750,000 shares,  (iii) rendered the non-employee Board members who serve as Plan
Administrator  eligible to receive option grants under the Discretionary  Option
Grant  Program,   (iv)  allowed  unvested  shares  issued  under  the  Plan  and
subsequently  repurchased  by the Company at the option  exercise price paid per
share to be reissued under the Plan,  (v) removed  certain  restrictions  on the
eligibility of non-employee  Board members to serve as Plan  Administrator,  and
(vi)  effected  a series of  additional  changes to the  provisions  of the Plan
(including  the  stockholder  approval  requirements,   the  transferability  of
non-statutory  stock options and the  elimination  of the six (6)-month  holding
period requirement as a condition to the exercise of stock appreciation  rights)
in  order  to take  advantage  of the  recent  amendments  to Rule  16b-3 of the
Securities and Exchange  Commission  which exempts  certain officer and director
transactions  under the Plan from the  short-swing  liability  provisions of the
federal  securities  laws. The 1997 Amendments were approved by the stockholders
at the 1997  Annual  Stockholders  Meeting.  

     H. On January 29,  1998,  the Board  adopted an amendment to the Plan which
increased the number of shares of Common Stock  available for issuance under the
Plan  by an  additional  500,000  shares.  The  amendment  was  approved  by the
stockholders at the 1998 Annual Stockholders  Meeting. 

     I. On September 18, 1998,  the Board adopted an amendment to the Plan which
increased the number of shares of Common Stock  available for issuance under the
Plan by an  additional  2,000,000  shares.  The  amendment  was  approved by the
stockholders  at the Special  Stockholders  Meeting held in January  1999. 

     J. On March 15, 1999,  the Board  authorized an amendment to the Plan which
(i) increased the number of shares of Common Stock  available for issuance under
the Plan by an  additional  6,689,167  shares(3),  (ii)  implemented a series of
automatic  increases to the share reserve under the Plan,  beginning February 1,
2000 and continuing from calendar year 20001 through  calendar year 2008,  (iii)
increased  the  maximum  number of shares  for which any one  individual  may be
granted stock options and separately  exercisable stock appreciation  rights per
calendar  year from 125,000  shares(4) to 5,000,000  shares(5),  (iv) effected a
series  of  changes  to  the  Automatic  Option  Grant  Program  (including  the
implementation  of a special  one-time  option grant to all  non-employee  Board
members  and  the   elimination  of  the  initial  and  annual  awards  made  to
non-employee  Board  members),  and (v) extended the term of the Plan by six (6)
years(6). The March 15, 1999 amendment is subject to stockholder approval at the
1999 Annual Stockholders  Meeting. If such stockholder approval is not obtained,
then any

- -----------------
(3)This  number  reflects  the  20-for-1  reverse  split  of  the  Common  Stock
   authorized by the Board on March 15, 1999, subject to stockholder approval at
   the 1999 Annual Meeting.

(4)This  number  reflects  the  20-for-1  reverse  split  of  the  Common  Stock
   authorized by the Board on March 15, 1999, subject to stockholder approval at
   the 1999 Annual Meeting.

(5)This  number  reflects  the  20-for-1  reverse  split  of  the  Common  Stock
   authorized by the Board on March 15, 1999, subject to stockholder approval at
   the 1999 Annual Meeting.

(6)This  amendment  was  authorized  by the Board on March 15, 1999,  subject to
   stockholder approval at the 1999 Annual Meeting.


                                       23
<PAGE>

options granted on the basis of the various share increases authorized under the
amendment will terminate  without becoming  exercisable for any of the shares of
Common Stock subject to those options, and no further option grants will be made
on the basis of those share increases. However, the Plan will continue to remain
in effect,  and option grants may continue to be made pursuant to the provisions
of the Plan in effect prior to the March 15, 1999 amendment, until the available
reserve of Common Stock as last approved by the stockholders has been issued. 

     K. Each option issued and outstanding under the 1990 Plan immediately prior
to the  Effective  Date shall be  incorporated  into this Plan and treated as an
outstanding  option under this Plan,  but each such option shall  continue to be
governed  solely by the terms and conditions of the instrument  evidencing  such
grant,  and nothing in this Plan shall be deemed to affect or  otherwise  modify
the rights or  obligations  of the holders of such options with respect to their
acquisition  of shares of Common Stock  thereunder.  

     L.  The  sale and  remittance  procedure  authorized  for the  exercise  of
outstanding  options under this Plan shall be available for all options  granted
under this Plan on or after the Effective Date and for all non-statutory options
outstanding  under  the 1990 Plan and  incorporated  into  this  Plan.  The Plan
Administrator  may also allow such  procedure to be utilized in connection  with
one or more disqualifying dispositions of Incentive Option shares effected after
the Effective Date,  whether such Incentive Options were granted under this Plan
or the 1990  Plan.  

     M. The  option  acceleration  provisions  of  Section  III of  Article  Two
relating  to  Corporate  Transactions  and  Changes in Control  may, in the Plan
Administrator's  discretion,  be extended to one or more stock options which are
outstanding  under the 1990 Plan on the Effective Date of this Plan but which do
not otherwise  provide for such  acceleration.  

     N. The Plan shall  terminate  upon the earlier of (i) December 31, 20087 or
(ii) the date on which all shares  available  for issuance  under the Plan shall
have been issued or cancelled pursuant to the exercise, surrender or cash-out of
the options  granted  under the Plan. If the date of  termination  is determined
under clause (i) above,  then all option grants  outstanding  on such date shall
thereafter  continue to have force and effect in accordance  with the provisions
of the  instruments  evidencing  such grants.  

     O. Options to purchase shares of Common Stock may be granted under the Plan
which are in excess of the number of shares then  available  for issuance  under
the Plan, provided each option granted is not to become exercisable, in whole or
in part, at any time prior to stockholder approval of an amendment authorizing a
sufficient  increase in the number of shares  available  for issuance  under the
Plan. 

- -----------------
7  The six (6)-year  extension of the term of the Plan is subject to stockholder
   approval at the 1999 Annual Meeting.


                                       24
<PAGE>

IV. USE OF PROCEEDS

     Any cash proceeds  received by the Company from the sale of shares pursuant
to options granted under the Plan shall be used for general corporate purposes.

V.  REGULATORY APPROVALS

     The  implementation  of the Plan, the granting of any option thereunder and
the issuance of stock upon the  exercise or surrender of the option  grants made
hereunder  shall be subject to the  Company's  procurement  of all approvals and
permits required by regulatory  authorities  having  jurisdiction over the Plan,
the options granted under it, and the stock issued pursuant to it.

VI.   NO EMPLOYMENT/SERVICE RIGHTS

     Neither the action of the Company in establishing  the Plan, nor any action
taken by the Plan Administrator  hereunder,  nor any provision of the Plan shall
be construed so as to grant any  individual the right to remain in the employ or
service of the Company (or any parent or subsidiary  corporation) for any period
of specific duration,  and the Company (or any parent or subsidiary  corporation
retaining  the services of such  individual)  may  terminate  such  individual's
employment or service at any time and for any reason, with or without cause.

VII.  MISCELLANEOUS PROVISIONS

     A. The right to acquire Common Stock or other assets under the Plan may not
be assigned, encumbered or otherwise transferred by any optionee.

     B. The  provisions of the Plan relating to the vesting and  termination  of
outstanding options shall be governed by the laws of the State of California, as
such laws are applied to contracts  entered into and performed in such State. 

     C. The provisions of the Plan shall inure to the benefit of, and be binding
upon,  the  Company  and  its  successors  or  assigns,   whether  by  Corporate
Transaction or otherwise,  and the optionees, the legal representatives of their
respective  estates,  their  respective  heirs or legatees  and their  permitted
assignees.




                                       25
<PAGE>





                                    EXHIBIT A

                      Non-Statutory Stock Option Agreement

                         Automatic Option Grant Program




                                       26
<PAGE>




[SHAMAN'S LETTERHEAD]


                                                            Exhibit B

 

To Our Stockholders:

      On March 23, 1999, Shaman  celebrated its 10th Anniversary.  Ten years ago
as we began our  journey,  we never  could  have  predicted  the path we are now
taking.   Yet  in  many  ways  our   destination   and  our  goal  has  remained
consistent--to  create novel,  proprietary  products to meet unmet health needs,
and in so doing,  to provide value for our  stockholders.  Our means to reaching
these goals has never wavered--to  collaborate with the rainforest's  indigenous
people to look for unique solutions to today's  healthcare  needs.  Although our
goals are the same, we have altered our path.

      As we now enter the market for  botanical  dietary  supplements,  it is as
though Shaman has come home--to an industry  that  appreciates  our hard work in
identifying  novel new botanical  products and our commitment to  sustainability
and  reciprocity,  to a pool of  potential  partners who  appreciate  the unique
quality and science we bring to the table, and to a growing consumer base who is
today more ready and eager than ever to try novel dietary supplements.

      We are entering this market as some important transitions are occurring in
the  industry.  The 1994 Dietary  Supplement  Health and  Education  Act (DSHEA)
created a clear and legal regulatory pathway for the introduction of our product
candidates.  More recently, the entrance of large consumer healthcare companies,
such as American Home Products,  Bayer, and Warner-Lambert,  has created a model
for branded,  proprietary,  higher margin products for us to follow.  Also, with
the maturing  demographics of the U.S. consumer public and a greater emphasis on
self-medication  and natural solutions,  the market seems to be primed and ready
to accept the types of products we plan to introduce.

      Finally,  and perhaps most importantly,  had we not made the investment in
our  technology  over the past 10 years,  we could not pursue  our new  business
today. The application of this "investment" to the dietary  supplement  business
is allowing us to change the  industry  even as we enter it.  Shaman  offers the
industry  a novel,  proprietary  product  pipeline,  the  depth of which has not
previously been available. It is a natural and logical extension of all that has
transpired at Shaman.

      Although the potential is great,  we can not make Shaman a success at this
time without additional funding. We expect to launch our first botanical dietary
supplement,  SB-300,  by mid-year.  However,  product  launches require adequate
support of inventory,  advertising,  and promotion.  For these activities,  more
funding is necessary.



                                    
<PAGE>



      As we  considered  funding  options,  we  were  acutely  sensitive  to the
concerns of our common stockholders about dilution.  Given our current low stock
price, and the anticipated  conversion of a large block of our current preferred
stockholders  to common stock,  we understand  your concerns.  In looking at our
options for raising  additional  funds,  our primary concern has been to protect
our common stockholders.  We feel we have a potential solution with our proposed
Rights Offering.

      The Rights  Offering  provides many benefits.  First and foremost,  common
stockholders  who  participate  in the Rights  Offering will be able to preserve
their pro rata stake in Shaman for a minimal additional investment,  and thereby
are protected  against the dilution  potential of our certain current  preferred
holders.  In fact, this may be the only solution to the current  dilution issue.
And, as for our current preferred stockholders,  they still receive the benefits
of conversion  which they initially  sought,  regardless of the Rights Offering.
Second,  the rights  offering  will provide cash to fund the launch of our first
product.

      While  we are  pursuing  the  Rights  Offering,  be  assured  that  we are
continuing  to explore  every  option  for  funding to bridge our needs from now
until the Rights  Offering  closes.  In  particular,  we have  initiated  a debt
financing, in which a group of investors,  including senior management,  members
of our Board of  Directors,  and several of our large  stockholders,  would loan
Shaman  approximately  $1 million.  This confirms the  commitment and confidence
that these individuals and institutions have in Shaman's new strategy.

      Finally,  our initial barometer of success at Shaman will be the launch of
our first dietary supplement  product,  SB-300.  This product, an extract of the
Croton tree, contains as one of its ingredients,  SP-303, the  clinically-proven
antidiarrheal  compound.  Given the continuing  unmet need for promoting  normal
bowel function in people with HIV/AIDS,  we will initially  target our marketing
and promotion to this  audience.  By launching  SB-300,  we also will be able to
keep our commitment to the HIV/AIDS Community by giving a portion of these sales
to the Shaman HIV Investment Trust, a Community-governed charitable organization
providing funding for HIV/AIDS services, education and research.

      In addition to preparing  for the launch of SB-300,  we are also  actively
engaged in discussions with other companies in the dietary  supplement  industry
for collaborations and  commercialization  partnerships.  We have had particular
interest from the large consumer healthcare companies targeting the mass market,
as well as  multi-level  marketing  companies.  Both of these types of potential
partners value the novelty and quality of Shaman's approach.



                                       2
<PAGE>


      In closing, we would like to say that everyone at Shaman is very committed
and working  diligently  to make our new  enterprise  a success,  for our future
customers  and for our  stockholders.  We have faced and managed  through a very
challenging turn of events. We responded quickly and showed great flexibility in
pursuing this new  opportunity.  We will settle for nothing but success,  and we
thank  you for your  dedication  to and  support  of  Shaman.  As we rise like a
Phoenix,  we are motivated to provide benefits to our customers  seeking healthy
lifestyles,  to our dedicated  stockholders  and to the communities with whom we
work.


/s/  Lisa A.  Conte                                /s/  G.  Kirk Raab          
- -------------------------------------              ----------------------
Lisa A. Conte                                      G. Kirk Raab
President and Chief Executive Officer              Chairman of the Board



                                       3
<PAGE>


[SHAMAN'S LETTERHEAD]



                                                             Exhibit C

                       
                          SHAMAN PHARMACEUTICALS, INC.
                            1999 Annual Meeting Proxy
                                       Q&A


- --------------------------------------------------------------------------------
              TO SPEAK TO A REPRESENTATIVE ON OUR INVESTOR HOTLINE,
  PLEASE DIAL 1-800-XXX-XXXX between the hours of X:XX A.M. and X:XX P.M. EDT.
- --------------------------------------------------------------------------------


      Following the  completion of the June 11, 1999,  Annual  Meeting of Shaman
Pharmaceuticals, and pending approval of the necessary proposals in the attached
proxy,  Shaman  expects  to  conduct a Rights  Offering,  and  intends to file a
registration  statement  with the SEC covering the issuance of rights to acquire
shares of Series R Preferred Stock to its stockholders. Shaman plans to offer to
stockholders   on  a  pro  rata  basis  shares  having  an  aggregate  value  of
$10,000,000.  You will receive more information on the Rights Offering following
the Annual Meeting, including detailed Questions and Answers (Q&A).

     The  approval of the  proposals  in this proxy will allow Shaman to proceed
with the Rights Offering to our current  stockholders.  The goals of this Rights
Offering are:

1) To attempt to protect the ownership of our current Common Stockholders in the
   face of  significant  potential  dilution  as  currently  held Series C and D
   Preferred  Stock  converts to Common  Stock.  The offering is  structured  to
   assure that the current stockholders of the Company will retain a significant
   portion of the value of the Company  without regard to  intervening  dilution
   caused by continued conversion of currently outstanding convertible Preferred
   Stock;

2) To raise funds for our Botanicals  operations,  and specifically, the launch 
   of our first product later this summer.

General:

I didn't get a proxy for some of my shares--why? How do I get one?

You may have bought stock at different  times,  or even from different  sources.
Each transaction is treated separately.

If the  stock  is held in your  name (in  other  words  you were  issued a stock
certificate),  then please contact: BankBoston, N.A., c/o Boston Equiserve, P.O.
Box 8040, Boston, MA 02266-8040; Telephone:
(781)575-3170; Fax: (781)828-8813.

If the stock is held in a "street name" (the  brokerage firm holds the shares of
your stock as part of your  brokerage  account),  then you should  contact  your
broker.

When is your stockholder meeting and where?

The Annual Meeting of  Stockholders  will be held on Friday June 11, 1999 at The
Embassy Suites, 250 Gateway Blvd, South San Francisco, California, 94080,at 9:00
A.M. Pacific Time.

How do I get something put on the agenda for the stockholder's meeting?

As stated in last year's 1998 Annual Meeting  proxy,  the deadline for getting a
stockholder  proposal on the agenda for this annual  meeting  was  December  17,
1998,  which  would have  allowed  sufficient  time for it to be included in the
proxy for this year's upcoming annual meeting.  There will be an opportunity for
stockholders to ask questions about the company and the proposals that have been
included in the proxy materials during the annual meeting.

Can I talk to someone at the Company?

We would be happy to answer your questions about the proxy and the proposed
Rights Offering. Please telephone our investor hotline at 1-800-XXX-XXXX between
the hours of X:XX A.M. and X:XX P.M. EDT.


<PAGE>

Why is this so complicated? Isn't there an easier way to raise money?

The Board of Directors and  management  have put a process in place,  that while
somewhat more  complicated  that other kinds of fundraising,  gives the existing
stockholders  an  opportunity  to participate in the financing and protect their
ownership  position  in the  Company,  while  allowing  the Company to raise the
capital necessary to implement its plans.

This is an attempt to protect the  ownership  position of existing  stockholders
who choose to participate in the face of significant dilution potential from our
current  Preferred  Stockholders and particularly the Series C Preferred when it
can begin to convert into Common Stock beginning later this year. By investing a
relatively  small  amount of money (up to $10  million),  the  stockholders  who
participate  in the  offering  can  leverage  over $150  million  which has been
invested  in the  company to date.  Using the  technology  and know how that was
developed  in the  pharmaceutical  business,  the  Company  hopes  to turn  that
investment  into  a  viable  near  term  opportunity  in the  botanical  dietary
supplement  business,  in addition to pursuing  outlicensing revenue that may be
generated from the pharmaceuticals business.

Reverse split:

What is a reverse split? What does it mean that I get 1 share for every 20 I now
own?

A  stockholder  who owns 100 shares prior to the reverse split will own 5 shares
afterwards.  Since  all  stockholders  will be  treated  in the  same  way,  the
ownership  position of each stockholder is unaffected.  In the simplest sense, a
reverse stock split is really just an accounting  adjustment-sort of like having
one two pound package versus two one pound packages-you still have two pounds.


The other effect of a reverse stock split is that the common shares  immediately
after the reverse split should trade at a  significantly  higher price per share
than before the split.

Why do we need to do a reverse split now?

The company is running out of authorized shares of Common Stock,  based upon the
expected conversion when the Series C and D Preferred Stock converts into Common
Stock.  If we do not have enough common  shares  available to  accommodate  this
conversion,  the company faces significant  financial penalties beyond currently
available  resources in the company.  The reverse  split will free up authorized
shares needed to meet these  conversion  obligations.  To the extent an existing
stockholder  participates  in the Rights  Offering at his pro rata  share,  this
should  substantially  reduce the potential  dilution effect of the Series C and
Series D Preferred Stock he would have experienced  without the Rights Offering.
For these  reasons we believe that it in the best  interest of  stockholders  to
vote in favor of a reverse stock split.

Isn't this just a way of freeing up more available shares to sell later?

We do need to have  sufficient  shares  available to allow for the conversion of
the Series C and D Preferred Stock into Common Stock,  without which the company
faces significant  financial  penalties beyond currently  available resources in
the  company.  These  shares may also be needed for the  conversion  into Common
Stock of the Series R Preferred  Stock issued in the Rights  Offering.  If we do
not need  these  shares  to  satisfy  conversions,  the  excess  shares  are not
currently anticipated to be issued.

The company is also asking for authorization for more common shares as well. Why
do you need more shares if you are doing the reverse split?

We may need both  approvals  so as to have  sufficient  shares  of Common  Stock
available to accommodate the conversion of the existing Preferred C and D stock,
as well as the conversion of the Series R Preferred Stock that will be issued in
the  Rights  Offering.  If we do not need  these  all these  shares  to  satisfy
conversions, the excess shares are not currently anticipated to be issued.



                                       2
<PAGE>


If these common shares are utilized for the  conversion of the Preferred R Stock
from the Rights Offering,  such shares may be required per a conversion formula.
To the extent an existing stockholder participates in the Rights Offering at his
pro rata share, this should  substantially  reduce the potential dilution effect
of the Series C and Series D Preferred Stock he would have  experienced  without
the Rights Offering.


If we do the reverse split, will we get listed on NASDAQ again?

There are a number of  requirements  that the  company  must meet in order to be
re-listed  on NASDAQ.  The  reverse  split does not  automatically  entitle  the
company to be re-listed.


What happens if I don't own at least 20 shares?

Stockholders  who own less than 20 shares  will be given 1 share of stock  after
the reverse split. In a similar manner,  those stockholders who own more than 20
shares would be rounded up in calculating the number of post-split  shares which
they would receive.  For example,  a stockholder who owned 25 shares of stock as
of the date of record would receive 2 shares post split.

How and when do I get the new shares? What do I do with the old shares?

As soon as practical after the effective date of the reverse split,  you will be
mailed forms that you will use to  surrender  the old stock  certificates.  Once
your old shares  have been  received,  new shares  will be mailed to you.  Those
stockholders  who have the stock  certificates  in their name will  receive  the
forms directly.  If your stock is held in a brokerage account,  your broker will
handle the paperwork on your behalf.

Will I have to pay taxes as a result of the reverse split?

In general  there will be no federal  tax  liability  as a result of the reverse
split if a stockholder is not rounded up as a result of the reverse stock split.
However,  stockholders  who receive a full share of stock instead of the partial
share of stock to which they are entitled may have a tax consequence relating to
the value of the fractional  additional  share they have  received.  The Company
urges  stockholders  to consult a tax  professional  who is capable of answering
specific  questions as they pertain to your individual  circumstance and federal
and state tax laws.

Additional Common Shares:

Why does the Company need so many more shares of Common Stock;  we just approved
an increase in Common shares from 40 million to 70 million shares?

The company is running out of common  shares based upon the expected  conversion
of the Series C and D Preferred Stock into common shares. The company also needs
to have enough common shares to accommodate the conversion of Series R investors
who  purchase in the Rights  Offering.  If we do not have enough  common  shares
available  to  accommodate  these  conversions,  the company  faces  significant
financial penalties beyond currently available resources in the company.

If these common shares are utilized for the  conversion of the Preferred R Stock
from the Rights Offering,  such shares may be required per a conversion formula.
Hence,  we feel that it is in the best interest of stockholders to vote in favor
of the increase in authorized common shares.

Won't the reverse stock split take care of the problem?

No, it may not. The Series C and D and R conversion  conversions are tied to the
actual  market  price of the stock.  Based upon the  current  share  price,  the
company  anticipates  needing both the reverse  split as well as the  additional
common shares being authorized.  We may not require all these additional shares,
yet we have built in a "safety factor" in calculating the number possibly needed
because,  if we do not have enough common shares available to accommodate  these
conversions,  the company faces significant financial penalties beyond currently
available  resources in the  company.  If we do not need these shares to satisfy
conversions, the excess shares are not currently anticipated to be issued.




                                       3
<PAGE>

Additional Preferred Shares:

Why do we need more  shares  again?  I thought we just  increased  the number of
Preferred shares from 1 million to 2 million?

In order to do the Rights Offering, the company has determined that it is in the
best interest of stockholders  to structure it as a Preferred  Stock  financing.
The  company  needs  stockholder  approval  in order to have  enough  shares  of
Preferred  Stock to complete the Rights  Offering as currently  structured.  The
number of preferred  shares was increased  previously,  but that did not address
the anticipated Rights Offering need for more shares of Preferred Stock.

The Rights Offering will provide the company with capital so that it can develop
the Botanicals  business.  In addition,  it attempts to protect the ownership of
our current Common Stockholders in the face of significant potential dilution as
currently held Series C and D Preferred Stock converts to Common Stock.  Without
the additional authorized preferred shares and the Rights Offering,  the company
would not have  sufficient  funds  needed to operate the business and would face
significant  dilution as a result of the conversion of the Preferred  Stock into
common.

What is the difference between "Common Stock" and "Preferred Stock"?

Common  Stock is  typically  the stock that trades once a company  goes  public.
Preferred  Stock has certain  features and rights that are different than Common
Stock. Different classes of preferred typically have different rights associated
with them with regard to conversion rights, voting, redemption etc.

If I vote for more  preferred  shares,  doesn't  that  just  mean  I'll get more
diluted?

If additional  preferred  shares are not  authorized,  the Company does not have
enough  preferred  shares to complete  the Rights  Offering as  structured,  and
existing  investors will be subject to  significant  dilution as a result of the
Series C and D conversions.  To the extent an existing stockholder  participates
in the Rights Offering at his pro rata share, this should  substantially  reduce
the potential  dilution  effect of the Series C and Series D Preferred  Stock he
would have experienced without the Rights Offering.  For this reason, we believe
it is in the best interest of  stockholders  to vote in favor of increasing  the
number of preferred shares.

How did the company  get into this  problem  with the Series C and D  Preferred?
Shouldn't they have known that this would negatively impact Common Stockholders?

We have  always  believed  that we  were  acting  in the  best  interest  of our
stockholders  to raise  financial  resources  under terms available at the times
such financings were undertaken.  Regardless of what has happened as a result of
the Series C and D  Preferred,  we view the Rights  Offering  as the best way to
protect current stockholders.

Can these preferred shares be issued to anyone? How do I know they won't go into
more death-spiral preferred types of offerings like the Series C & D?

The intention is to offer all the new Preferred  shares in the Rights  Offering.
If we do not need these shares to satisfy conversions, the excess shares are not
currently anticipated to be issued. The existing investors are being offered the
opportunity to buy the shares in this offering.  If existing stockholders do not
participate  to the full value of the offering,  then the company will offer the
uncommitted amount to select institutional investors.

To the extent an existing stockholder participates in the Rights Offering at his
pro rata share, this should  substantially  reduce the potential dilution effect
of the Series C and Series D Preferred Stock he would have  experienced  without
the Rights Offering.

Amendment to the Rights of the Preferred Stock

Why are you seeking to amend the rights of the Preferred Stockholders?

At  present,  the  Preferred  Stockholders  potentially  have a right to  be
repaid their  investment  (or a  significant  penalty  amount) in the event of a
change  of  control  of over 50% of the  Company's  voting  stock.  The  Company
believes that under certain  circumstances  the proposed  Rights  Offering could
inadvertently trigger this provision.



                                       4
<PAGE>


Why would the Rights Offering potentially trigger a change of control? What is a
change of control?

The Rights  Offering could trigger a change of control if some  investors  chose
not to  participate  while  others  decided  to invest  more than their pro rata
share.  While the  Stockholders  in the company  might not change,  the relative
stock holdings could change enough to trigger the change of control provision.

A change of control in this context means that the stockholder  base of the
Company  changes  such as that over 50% of voting  power of the Company that was
previously  held by one group of persons is tranferred to a different  person or
persons who previously did not hold a significant, or controlling, amount of our
voting stock;  typically this type of sudden and significant  change is a result
of a merger or takeover. A Rights Offering also could have the same effect.

What are the ramifications of a change of control?

Under the  Company's  current  Certificate  of  Incorporation,  a change of
control is treated as an event that would  require  that the  Company  repay the
Preferred  Stockholders their liquidation  preference amount or other penalties.
Since  this could  jeopardize  the  ability of the  Company to effect the Rights
Offering,   it  is  neither  in  the  best  interest  of  the  Company  nor  its
stockholders, and the Company is recommending that stockholders vote in favor of
this amendment.

Why is it in the best interests of the stockholders  to amend the rights of the 
Preferred Stockholders?

This amendment would  eliminate the  possibility  that the Rights Offering would
trigger a change of  control.  By  voting in favor of this  amendment,  it would
ensure that Shaman would not incur any penalties from a possible trigger of this
provision and would therefore eliminate the possibilty that the provision could
cost the Company to be unable to effect the Rights Offering.

Option Plan:

How can you  ask for an  option  plan to  reward  management  and the  board  of
directors when the stock has performed so poorly?

The  management  and  Board  are  as  disappointed  as the  stockholders  in the
performance of the stock.

In order  for the  company  to be  successful  in the  future,  a number  of key
milestones  must be met. To meet those,  the company must be able to attract and
retain key  management;  stock  options are an effective  way to do this.  As an
alternative,  Shaman would have to utilize substantial cash reserves to attract,
hire,  and retain new  employees or to utilize  consultants.  Employees  will be
rewarded as the company is successful  and creates  value for all  stockholders.
Currently,  due to the stock price,  no currently held options have any positive
value. Additionally,  all members of the Board of Directors have surrendered all
previously held stock options.

Does  this  mean  management/employees/the   board  own  20%  of  the
company?  Isn't that a lot?

The option pool will at any given time represent at most 20% of the  outstanding
shares of the  company,  which is typical for many  technology-based  companies.
However, all of these shares may not necessarily be granted. The actual issuance
of options can only be made with Board approval and are typically  vested over a
four-year period.

Does this mean the current  employees get even more options?  At what price? Who
is getting them, and how many is each person getting?

The  employee  option  pool  will  provide  options  to  existing  employees  as
appropriate with the approval of the Board of Directors. In order to attract and
retain  key  employees,  the  long-term  value  of the  stock  options  must  be
sufficient so as to be competitive. The dietary supplement business will require
that the company hire experienced  management to run that business;  options are
required for these employees. Given the amount of new shares that will be issued
as  part  of  the  Rights  Offering,  the  option  pool  needs  to be  increased
proportionally. Presently, our intention is to ask all employees who receive new
options  to  surrender  all their old  options  before  receiving  new  options.
Currently,  due to the stock price,  no currently held options have any positive
value.

Who decides how the option pool is split up?

The Board has a compensation  committee that determines  appropriate  grants for
senior  management.  Senior management makes  recommendations to the Board as to
appropriate  grants for other  employees.  In both cases,  option grants must be
approved  first  by the  compensation  committee,  then  by the  full  Board  of
Directors.



                                       5
<PAGE>


What does the automatic increase of 4% per year mean?

This means that the option pool will be able to  increase by 4% a year,  however
in no case will the option pool  available  for future  grants exceed 20% of the
outstanding  shares at a given  time.  The  company  believes  that this  annual
increase  will be adequate  to provide  options to new  employees  as well as to
existing  employees  as  necessary.  This is done so that  stockholders  are not
inconvenienced by seeking approval every year.

What does the maximum grant number mean?

This is the maximum number of shares that can be granted to any one employee. It
is required by law to set this number in the option plan and to have it approved
by proxy by the stockholders.

Why are you extending the plan?

The  existing  plan is set to expire  in 2002.  Given all the work that has gone
into  developing  this plan,  the Board felt that it would be cost effective and
therefore prudent to extend the plan until 2008.

Why are the  non-employee  members  of the  Board  of  Directors  being  granted
options? Why are they surrendering their existing options?

Each of the non-employee Directors are given an option grant as compensation for
their work on the Board.  Each of them has agreed to  surrender  their  existing
grants and receive new option  grants that will be made at the same price as the
Preferred R stock will  convert.  The Board will  therefore be on an equal basis
with the existing stockholders who participate in the Rights Offering.



                                       6
<PAGE>




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