SHAMAN PHARMACEUTICALS INC
SC 13D, 2000-01-27
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549



                                 ---------------

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934


                                 ---------------

                          SHAMAN PHARMACEUTICALS, INC.
                                (Name of Issuer)

                                  COMMON STOCK
                         (Title of Class of Securities)

                                    819319 10
                                 (CUSIP Number)

    William D. Savoy                             Gail J. Gordon
    Vulcan Ventures Incorporated                 Foster Pepper & Shefelman PLLC
    110-110th Avenue N.E., Suite 550             1111 Third Avenue, Suite 3400
    Bellevue, WA  98004                          Seattle, WA  98101
    (206) 453-1940                               (206) 447-4400

(Name, Address and Telephone Number of Persons Authorized to Receive Notices and
Communications)

                                December 3, 1999
             (Date of Event which Requires Filing of This Statement)

                                 ---------------

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule because of ss.ss.  240.13d-1(e),  240.13d-1(f) or 240.13nd-1(g),  check
the following box. |_|

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the  schedule  including  all  exhibits.  See  ss.240.13d-7  for other
parties to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


<PAGE>

- --------------------------                             ------------------------
 CUSIP NO.  819319 10                  13D              Page 2 of 9 Pages
            ---------
- --------------------------                             ------------------------

- --------------------------------------------------------------------------------
 1   NAME OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

             Vulcan Ventures Incorporated
- --------------------------------------------------------------------------------
 2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) |_|
                                                               (b) |_|
- --------------------------------------------------------------------------------
 3   SEC USE ONLY


- --------------------------------------------------------------------------------
 4   SOURCE OF FUNDS*

          WC
- --------------------------------------------------------------------------------
 5   CHECK BOX  IF  DISCLOSURE  OF  LEGAL  PROCEEDINGS  IS REQUIRED  PURSUANT TO
     ITEMS 2(d) OR 2(E)


- --------------------------------------------------------------------------------
 6   CITIZENSHIP OR PLACE OF ORGANIZATION

        State of Washington
- --------------------------------------------------------------------------------
   NUMBER OF      7    SOLE VOTING POWER
    SHARES                         0 shares
 BENEFICIALLY   ----------------------------------------------------------------
   OWNED BY       8    SHARED VOTING POWER
     EACH                          528,677,459 shares(1)
   REPORTING    ----------------------------------------------------------------
    PERSON        9    SOLE DISPOSITIVE POWER
     WITH                          0 shares
                ----------------------------------------------------------------
                  10   SHARED DISPOSITIVE POWER
                                   528,677,459 shares(1)
- --------------------------------------------------------------------------------
 11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          528,677,459 shares(1)
- --------------------------------------------------------------------------------
 12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*


- --------------------------------------------------------------------------------
 13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          71.1 %
- --------------------------------------------------------------------------------
 14  TYPE OF REPORTING PERSON*

          CO
- --------------------------------------------------------------------------------
- ---------------
(1) Directly owned by Vulcan  Ventures  Incorporated.  Paul G. Allen is the sole
shareholder  of Vulcan  Ventures  Incorporated  and may be deemed to have shared
voting and dispositive power with respect to such shares.

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


- --------------------------                             ------------------------
 CUSIP NO.  819319 10                  13D              Page 3 of 9 Pages
            ---------
- --------------------------                             ------------------------

- --------------------------------------------------------------------------------
 1   NAME OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

             Paul G. Allen
- --------------------------------------------------------------------------------
 2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) |_|
                                                               (b) |_|
- --------------------------------------------------------------------------------
 3   SEC USE ONLY


- --------------------------------------------------------------------------------
 4   SOURCE OF FUNDS*

          AF
- --------------------------------------------------------------------------------
 5   CHECK BOX  IF  DISCLOSURE  OF  LEGAL  PROCEEDINGS  IS REQUIRED  PURSUANT TO
     ITEMS 2(d) OR 2(E)


- --------------------------------------------------------------------------------
 6   CITIZENSHIP OR PLACE OF ORGANIZATION

        United States of America
- --------------------------------------------------------------------------------
   NUMBER OF      7    SOLE VOTING POWER
    SHARES                         0 shares
 BENEFICIALLY   ----------------------------------------------------------------
   OWNED BY       8    SHARED VOTING POWER
     EACH                          528,677,459 shares(1)
   REPORTING    ----------------------------------------------------------------
    PERSON        9    SOLE DISPOSITIVE POWER
     WITH                          0 shares
                ----------------------------------------------------------------
                  10   SHARED DISPOSITIVE POWER
                                   528,677,459 shares(1)
- --------------------------------------------------------------------------------
 11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          528,677,459 shares(1)
- --------------------------------------------------------------------------------
 12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*


- --------------------------------------------------------------------------------
 13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          71.1 %
- --------------------------------------------------------------------------------
 14  TYPE OF REPORTING PERSON*

          IN
- --------------------------------------------------------------------------------
- ---------------
(1) Directly owned by Vulcan  Ventures  Incorporated.  Paul G. Allen is the sole
shareholder  of Vulcan  Ventures  Incorporated  and may be deemed to have shared
voting and dispositive power with respect to such shares.

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>

Item 1.  Security and Issuer
- ------   -------------------

         This statement relates to the common stock,  $0.001 par value per share
(the "Common Stock"), of Shaman  Pharmaceuticals,  Inc., a Delaware  corporation
(the  "Issuer"),  including  the shares of Common Stock into which shares of the
Issuer's  Series R  Preferred  Stock,  $0.001  par value per  share  ("Series  R
Stock"),  are convertible.  The Issuer's principal executive offices are located
213 E. Grand Avenue South, San Francisco,  California  94080.  Amounts stated in
this statement reflect a one-for-twenty reverse split of the number of shares of
common stock issued and outstanding effective June 22, 1999.

Item 2.  Identity and Background
- ------   -----------------------

     The persons filing this statement are Vulcan Ventures Incorporated ("Vulcan
Ventures") and Paul G. Allen. Vulcan Ventures is a Washington  corporation whose
principal business is investing in various companies.  Paul G. Allen is its sole
shareholder.  The  principal  office of Vulcan  Ventures is located at 110-110th
Avenue N.E.,  Suite 550,  Bellevue,  Washington  98004.  All of Vulcan Ventures'
executive  officers and  directors  are U.S.  citizens.  Their  names,  business
addresses and principal occupations are as follows:

          Paul G. Allen, Vulcan Ventures Incorporated,  110 - 110th Avenue N.E.,
     Suite 550, Bellevue, Washington 98004. Mr. Allen is Chairman, President and
     sole  shareholder of Vulcan Ventures and a Director and sole shareholder of
     Vulcan Northwest Inc.

          William D. Savoy, Vulcan Northwest Inc.,  110-110th Avenue N.E., Suite
     550, Bellevue, Washington 98004. Mr. Savoy is Vice President and a Director
     of Vulcan Ventures and Chairman and President of Vulcan Northwest Inc.

          Bert E. Kolde,  Vulcan Ventures  Incorporated,  110-110th Avenue N.E.,
     Suite 550,  Bellevue,  Washington  98004.  Mr.  Kolde is a Vice  President,
     Secretary, Treasurer and a Director of Vulcan Ventures and a Vice President
     of Vulcan Northwest Inc.

          Jo Allen Patton,  Vulcan Northwest Inc.,  110-110th Avenue N.E., Suite
     550,  Bellevue,  Washington  98004.  Ms. Patton is Vice Chairman and a Vice
     President of Vulcan Ventures and Vulcan Northwest Inc.

     During the last five years, Mr. Allen and Vulcan Ventures have not, nor, to
the best knowledge of Vulcan  Ventures,  has any other person named in this Item
2, been  convicted in a criminal  proceeding  (excluding  traffic  violations or
similar  misdemeanors)  or been a party to a civil  proceeding  of a judicial or
administrative body of competent  jurisdiction as a result of which he is or was
subject to a judgment,  decree or final order enjoining future violations of, or
prohibiting or mandating activities subject to, federal or state securities laws
or finding any violation with respect to such laws.

Item 3.  Source and Amount of Funds or Other Consideration
- ------   -------------------------------------------------

     Vulcan Ventures funded its purchases of the Issuer's capital stock from its
own  working  capital.  None of the  funds  used  to  purchase  such  securities
consisted of funds or other consideration borrowed or otherwise obtained for the
purpose of acquiring, holding, trading or voting the shares of common stock.

Item 4.  Purpose of Transaction
- ------   ----------------------

     Vulcan  Ventures and Mr. Allen  acquired  the  securities  reported in this
statement for  investment  purposes.  Vulcan  Ventures or Mr. Allen may purchase
additional  shares  of common  stock  from time to time,  depending  on  various
factors,  including,  without  limitation,  the price of the common stock, stock
market conditions and the business prospects of the Issuer.  Vulcan Ventures and
Mr. Allen may also determine to dispose

                                  Page 4 of 9
<PAGE>

of some or all of their  beneficial  holdings of the Issuer's  securities.  They
reserve the right to increase  or decrease  their  holdings on such terms and at
such times as they may decide.

     Except as set forth in this  statement,  Vulcan Ventures and Mr. Allen have
no  present  plan  or  proposal  that  relates  to or  would  result  in (i) the
acquisition  by any  person  of  additional  securities  of the  Issuer,  or the
disposition  of  securities  of the  Issuer;  (ii)  an  extraordinary  corporate
transaction, such as a merger, reorganization,  liquidation, or sale or transfer
of a material amount of assets involving the Issuer or any of its  subsidiaries,
(iii) any change in the Issuer's present Board of Directors or management,  (iv)
any material change in the Issuer's present capitalization or dividend policy or
any other material change in the Issuer's business or corporate  structure,  (v)
any change in the Issuer's  charter or by-laws or other  actions that may impede
the  acquisition  of control of the Issuer by any  person,  (vi) any change that
would result in the Issuer's  common stock becoming  eligible for termination of
its registration  pursuant to Section 12(g)(4) of the Securities Exchange Act of
1934, as amended,  or to cease to be authorized to be quoted in Nasdaq, or (vii)
any similar action.

Item 5.  Interest in Securities of the Issuer
- ------   ------------------------------------

     As of the date hereof, Vulcan Ventures owns of record and beneficially, (i)
20,000  shares of the Issuer's  Series C Preferred  Stock,  par value $0.001 per
share  ("Series  C Stock"),  (ii)  110,263  shares of the Series R Stock,  (iii)
warrants to purchase 8,333 shares of Series R Stock (the  "Warrants"),  and (iv)
5,459,812 shares of the Common Stock (the "Common Shares"),  including 5,299,418
shares  paid as a  dividend  on the  Series C Stock on  November  29,  1999.  In
addition,  assuming  exercise of the Warrants,  Vulcan Ventures may be deemed to
own beneficially an additional 523,217,647 shares of Common Stock into which the
Series R Preferred Stock automatically is convertible on February 1, 2000, based
upon the Conversion Price, as defined below, as of January 26, 2000. As the sole
shareholder of Vulcan  Ventures,  Mr. Allen shares voting and dispositive  power
with Vulcan  Ventures  over the shares of the  Issuer's  capital  stock owned by
Vulcan Ventures. Therefore, Mr. Allen may be deemed the beneficial owner of such
shares.

     The Issuer  issued  Series R Stock  pursuant  to the terms set forth in the
Issuer's  rights  offering,  which was  completed  in August  1999 (the  "Rights
Offering").  In the Rights Offering, the Issuer offered shares of Series R Stock
at a price of $15.00 per share to the  holders of record of the Common  Stock as
of July 14, 1999 (including Vulcan Ventures).  Vulcan Ventures  purchased 93,333
shares of Series R Stock for cash and 16,930  shares of Series R Stock and 8,333
Warrants for the  cancellation  of indebtedness of the Issuer to Vulcan Ventures
under a bridge loan. As of November 30, 1999,  777,101 shares of Series R Stock,
including those acquired by Vulcan Ventures, were outstanding.

     On  February  1,  2000,  each  share of Series R Stock  automatically  will
convert into a number of shares of Common  Stock equal to $15.00  divided by the
conversion price then in effect (the "Conversion  Price").  The Conversion Price
will be equal to the  lesser of (i) $0.10 per  share,  or (ii) the price that is
equal to 10% of the  average  closing  sales  price of  Common  Stock for the 10
trading  days ending  three  trading  days prior to February 1, 2000.  The exact
number of shares of Common Stock into which each share of Series R Stock will be
converted  will not be  calculable  until  January  27,  2000.  Pursuant to Rule
13d-3(d)(1) of the Securities  Exchange Act of 1934 (the "Exchange Act"), Vulcan
Ventures  is  deemed  beneficially  to own  securities  that it has the right to
acquire within 60 days.  Therefore,  Vulcan Ventures was deemed  beneficially to
own the Underlying Shares as of December 3, 1999.

     Based upon the  Conversion  Price of the Series R Stock as of  December  3,
1999,  the shares of Series R Stock that Vulcan  Ventures holds and the Series R
Stock  issuable  upon exercise of the Warrants  would  convert into  847,114,286
shares of Common Stock  ("Underlying  Shares") upon the automatic  conversion of
the Series R Stock on February 1, 2000. In accordance  with Rule  13d-3(d)(1)(i)
of the Exchange  Act,  assuming  conversion of only the shares of Series R Stock
owned by Vulcan Ventures and the shares of Series R Stock issuable upon exercise
of the Warrants,  the sum of the  Underlying  Shares and the Common Shares would
represent  93.5% of the total shares of Common Stock  outstanding as of December
3, 1999. Based upon the Conversion Price of the Series R Stock as of January 26,
2000,  the shares of Series R Stock that Vulcan  Ventures holds and the Series R
Stock  issuable  upon exercise of the Warrants  would  convert into  523,217,647
Underlying Shares. In that case, the sum of the Underlying Shares and the Common
Shares  would  represent  71.1% of  the  Common  Stock  outstanding.    However,
all  shares of  the  Series R  Stock  will  automatically  convert  to shares of
Common  Stock  on  February  1,  2000.  Based  upon  the  Conversion Price as of
January  26, 2000  and  assuming  conversion  into  Common  Stock on February 1,

                          Page 5 of 9
<PAGE>

2000 of all of  the outstanding shares of Series R Stock, the  Common Shares and
the Common  Stock into  which  Vulcan Venture's  shares of Series R Stock  would
convert would represent 13.6% of the total shares of Common Stock.

     Vulcan Ventures  purchased  20,000 shares of Series C Stock in a registered
public  offering  pursuant to a prospectus  dated August 18, 1998. Each share of
Series C Stock  entitles  the holder to  receive  cumulative  dividends  payable
semi-annually  on May  30  and  November  29 of  each  year  as  follows:  (1) a
stock-on-stock  dividend  of $10.00 per  annum,  paid in  arrears,  in shares of
common stock, valued at 85% of the average closing price of the common stock for
the 10 trading  days ending  three  trading  days prior to the date on which the
dividend  is paid;  plus (2) a cash  amount  payable in shares of common  stock,
valued  at 85% of the  average  closing  price of the  common  stock  for the 10
trading days ending  three  trading days prior to the date on which the dividend
is paid, if the Issuer is unable under Delaware law to pay the cash amount. Each
share of Series C Stock is  convertible,  at any time  commencing  on August 18,
1999 at the election of the holder,  and  automatically on August 18, 2004, into
the greater of (1) 0.8333 shares of common stock or (2) such number of shares of
common stock as equals $100 divided by 85% of the average  closing  price of the
common stock for the 10 trading days ending three trading days prior to the date
of conversion. The Issuer's Certificate of Incorporation prohibits conversion of
the  Series C Stock to the  extent  such  conversion  would  cause the  holder's
beneficial ownership of Common Stock to exceed 4.9% of the outstanding shares of
Common Stock.

     To the best knowledge of Vulcan  Ventures and Mr. Allen,  none of the other
parties named in Item 2 owns any of the Issuer's common stock.

     Except as set forth in this  statement,  Vulcan Ventures and Mr. Allen have
not, nor, to the knowledge of Vulcan Ventures has any of its executive officers,
directors or  controlling  persons,  effected any  transactions  in the Issuer's
common stock during the past sixty days.

Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to
Securities of the Issuer.

     The Issuer  has  registered  100,000  shares of Common  Stock  that  Vulcan
Ventures acquired in a private placement in November 1998 for resale pursuant to
a  prospectus  dated  December  1,  1998,  which  forms  part of a  Registration
Statement on Form S-3.

     Except as set forth in this statement, Vulcan Ventures and Mr. Allen do not
have,  nor,  to the  knowledge  of  Vulcan  Ventures  does any of the  executive
officers,  directors  or  controlling  persons  of  Vulcan  Ventures  have,  any
contracts,  arrangements,  understandings or relationships  (legal or otherwise)
with any person with respect to any  securities  of the Issuer,  finder's  fees,
joint ventures, loan or option agreements, puts or calls, guarantees of profits,
division of profits or loss, or the giving or withholding of proxies.

Item 7.  Material To Be Filed as Exhibits.
- ------   ---------------------------------

     Exhibit      Description
     -------      -----------

      99.1        Joint Filing Agreement
      99.2        Power of Attorney filed on August 30, 1999, with the Schedule
                  13G of  Vulcan  Ventures, Incorporated  and Paul G. Allen for
                  Pathogenesis, Inc. (Incorporated herein by reference.)

                                   Page 6 of 9

<PAGE>


                                   SIGNATURES

     After  reasonable  inquiry and to the best of my  knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.

                          VULCAN VENTURES INCORPORATED



     January 26, 2000                By:      /s/ William D. Savoy
                                        ----------------------------------------
                                        William D. Savoy, Vice President


     January 26, 2000                                   *
                                     -------------------------------------------
                                     Paul G. Allen


                                     *By:     /s/ William D. Savoy
                                         ---------------------------------------
                                      William  D. Savoy as  Attorney-in Fact for
                                      Paul G.  Allen  pursuant  to  a  Power  of
                                      Attorney  filed on  August 30,  1999, with
                                      the  Schedule  13G  of  Vulcan  Ventures,
                                      Incorporated and Paul G. Allen for
                                      Pathogenesis, Inc. and incorporated herein
                                      by reference.

                                   Page 7 of 9

<PAGE>

                                  EXHIBIT INDEX



     Exhibit      Description
     -------      -----------

      99.1        Joint Filing Agreement
      99.2        Power of Attorney filed on August 30, 1999, with the Schedule
                  13G of  Vulcan  Ventures, Incorporated  and Paul G. Allen for
                  Pathogenesis, Inc. (Incorporated herein by reference.)

                                  Page 8 of 9




                                  EXHIBIT 99.1

                             Joint Filing Agreement
                             ----------------------


     We, the  signatories of the statement to which this Joint Filing  Agreement
is attached,  hereby  agree that such  statement  is filed,  and any  amendments
thereto filed by either or both of us will be filed, on behalf of each of us.

Dated:  January 26, 2000.

                                    VULCAN VENTURES INCORPORATED





     January 26, 2000                By:      /s/ William D. Savoy
                                        ----------------------------------------
                                        William D. Savoy, Vice President


     January 26, 2000                                   *
                                     -------------------------------------------
                                     Paul G. Allen


                                     *By:     /s/ William D. Savoy
                                         ---------------------------------------
                                      William  D. Savoy as  Attorney-in Fact for
                                      Paul G.  Allen  pursuant  to  a  Power  of
                                      Attorney  filed on  August 30,  1999, with
                                      the  Schedule  13G  of  Vulcan  Ventures,
                                      Incorporated and Paul G. Allen for
                                      Pathogenesis, Inc. and incorporated herein
                                      by reference.



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