SHAMAN PHARMACEUTICALS INC
PRE 14A, 2000-01-12
PHARMACEUTICAL PREPARATIONS
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                                  SCHEDULE 14A
                                 (Rule 14a-101)
                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION
           Proxy Statement Pursuant to Section 14(a) of the Securities
                              Exchange Act of 1934

     |X|  Filed by the registrant
     |_|  Filed by a party other than the registrant

          Check the appropriate box:

     |X|  Preliminary Proxy Statement       |_| Confidential, for Use of the
                                                Commission Only (as permitted by
                                                Rule 14a-6(e)(2))
     |_|  Definitive Proxy Statement
     |_|   Definitive Additional Materials
     |_|   Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

                          Shaman Pharmaceuticals, Inc.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)


- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)


Payment of Filing Fee (Check the appropriate box):

     |X|  No fee required.

     |_|  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and
          0-11.

          Title of each class of securities to which transaction applies:

- --------------------------------------------------------------------------------
(1)  Aggregate number of securities to which transactions applies:

- --------------------------------------------------------------------------------
(2)  Per unit price or other underlying value of transaction computed pursuant
     to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is
     calculated and state how it was determined):

- --------------------------------------------------------------------------------
(3)  Proposed maximum aggregate value of transaction:

- --------------------------------------------------------------------------------
(4)  Total fee paid:

- --------------------------------------------------------------------------------
     |_|  Fee paid previously with preliminary materials:

- --------------------------------------------------------------------------------

     |_| Check box if any part of the fee is offset as provided by Exchange  Act
Rule  0-11(a)(2)  and identify the filing for which the  offsetting fee was paid
previously.  Identify the previous filing by registration  statement  number, or
the form or schedule and the date of its filing.

(5)  Amount Previously Paid:

- --------------------------------------------------------------------------------
(6)  Form, Schedule or Registration Statement No.:

- --------------------------------------------------------------------------------
(7)  Filing Party:

- --------------------------------------------------------------------------------
(8)  Date Filed:

- --------------------------------------------------------------------------------


<PAGE>


[LOGO] Shaman
- ---------------------
PHARMACEUTICALS, INC.


                          SHAMAN PHARMACEUTICALS, INC.
                              213 East Grand Avenue
                      South San Francisco, California 94080

                                February 9, 2000
Dear Stockholder:

     You are  cordially  invited to attend the Special  Meeting of  Stockholders
("Special Meeting") of Shaman Pharmaceuticals,  Inc. (the "Company"), which will
be held at 9:00 A.M.  Pacific  Standard  Time on Friday,  March 10,  2000 at The
Embassy Suites,  250 Gateway Boulevard,  South San Francisco,  California 94080,
for the following purposes:

     (i)  To approve the transfer of all of the assets and liabilities of Shaman
          Pharmaceuticals,  Inc. to Shaman.com,  Inc. ("Shaman.com") in exchange
          for shares of Common Stock of Shaman.com;

     (ii) To approve an  amendment to the Amended and  Restated  Certificate  to
          delete the provision  stating that a sale of all or substantially  all
          of  the  assets  the  Company  will  be  treated  as  a   liquidation,
          dissolution  or winding up of the  Company,  for purposes of causing a
          required liquidation preference  distribution to the holders of Series
          C Preferred Stock; and

    (iii) To  transact  such other  business  as may  properly  come  before the
          Special  Meeting and any  adjournment  or  postponement  thereof.

     The  enclosed  Proxy  Statement  more fully  describes  the  details of the
business  to be  conducted  at the  Special  Meeting.  After  reading  the Proxy
Statement,  please mark,  date,  sign and return the enclosed  proxy card in the
accompanying  reply  envelope  as soon as  possible.  If you attend the  Special
Meeting and vote by ballot,  your proxy will be  automatically  revoked and only
your vote at the Special  Meeting will be counted.  YOUR SHARES  CANNOT BE VOTED
UNLESS YOU MARK,  DATE, SIGN AND RETURN THE ENCLOSED PROXY OR ATTEND THE SPECIAL
MEETING AND VOTE IN PERSON.

     After  careful   consideration,   the  Company's  Board  of  Directors  has
unanimously approved the proposals and recommends that you vote IN FAVOR OF each
such proposal.

                                        Sincerely,



                                        Lisa A. Conte
                                        President, Chief Executive Officer,
                                        Chief Financial Officer and director

================================================================================
                                    IMPORTANT

     PLEASE  MARK,  DATE,  SIGN AND RETURN THE  ENCLOSED  PROXY  PROMPTLY IN THE
ACCOMPANYING  POSTAGE-PAID  RETURN ENVELOPE SO THAT, IF YOU ARE UNABLE TO ATTEND
THE SPECIAL MEETING, YOUR SHARES MAY BE VOTED.
================================================================================


<PAGE>


                          SHAMAN PHARMACEUTICALS, INC.

                   -----------------------------------------
                   NOTICE OF SPECIAL MEETING OF STOCKHOLDERS
                          TO BE HELD ON MARCH 10, 2000
                   -----------------------------------------

TO THE STOCKHOLDERS OF SHAMAN PHARMACEUTICALS, INC.:


     NOTICE IS HEREBY  GIVEN that a Special  Meeting of  Stockholders  ("Special
Meeting")  of  Shaman   Pharmaceuticals,   Inc.,  a  Delaware  corporation  (the
"Company"), will be held at 9:00 A.M. Pacific Standard Time on Friday, March 10,
2000  at The  Embassy  Suites,  250  Gateway  Boulevard,  South  San  Francisco,
California 94080, for the following purposes:

     (1) To approve the transfer of all of the assets and  liabilities of Shaman
     Pharmaceuticals,  Inc. to Shaman.com,  Inc.  ("Shaman.com") in exchange for
     shares of Common Stock of Shaman.com;

     (2) To approve an  amendment  to the Amended and  Restated  Certificate  to
     delete the provision stating that a sale of all or substantially all of the
     assets the Company will be treated as a liquidation, dissolution or winding
     up  of  the  Company,  for  purposes  of  causing  a  required  liquidation
     preference distribution to the holders of Series C Preferred Stock; and

     (3) To transact such other business as may properly come before the Special
     Meeting and any adjournment or postponement thereof.

     The  foregoing  items of  business  are more fully  described  in the Proxy
Statement accompanying this Notice.

     The record date for determining those  stockholders  entitled to notice of,
and to vote at, the Special Meeting and any  adjournment  thereof is February 2,
2000.  The stock  transfer  books will not be closed between the record date and
the date of the Special Meeting. A list of the stockholders  entitled to vote at
the Special  Meeting will be available for inspection at the Company's  offices,
213 East Grand Avenue, South San Francisco, California 94080, for a period of 10
days prior to the Special Meeting.

     All  stockholders  are cordially  invited to attend the Special  Meeting in
person.   Whether  or  not  you  plan  to  attend,  please  carefully  read  the
accompanying  Proxy  Statement,  which describes the matters to be voted upon at
the Special Meeting,  and mark, date, sign and return the enclosed proxy card in
the reply envelope provided. Should you receive more than one proxy because your
shares are  registered in different  names and  addresses,  each proxy should be
returned  to ensure  that all your  shares  would be voted.  You may revoke your
proxy at any time  prior to the  Special  Meeting.  If you  attend  the  Special
Meeting and vote by ballot,  your proxy vote will be revoked  automatically  and
only your vote at the Special Meeting will be counted. The prompt return of your
proxy card will assist us in preparing for the Special Meeting.

Sincerely,

Lisa A. Conte
President, Chief Executive Officer, Chief Financial Officer and Director
South San Francisco, California
February 9, 2000

YOUR VOTE IS VERY IMPORTANT,  REGARDLESS OF THE NUMBER OF SHARES YOU OWN. PLEASE
READ THE ATTACHED PROXY STATEMENT  CAREFULLY.  IF YOU DO NOT EXPECT TO ATTEND IN
PERSON,  PLEASE  COMPLETE,  SIGN, DATE AND RETURN THE ENCLOSED PROXY CARD IN THE
ACCOMPANYING ENVELOPE AS PROMPTLY AS POSSIBLE.


<PAGE>




                          SHAMAN PHARMACEUTICALS, INC.
                              213 East Grand Avenue
                      South San Francisco, California 94080

                      -------------------------------------

                                 PROXY STATEMENT

                      -------------------------------------
                    FOR THE SPECIAL MEETING OF STOCKHOLDERS
                          TO BE HELD ON MARCH 10, 2000


General Information for Stockholders

     The  enclosed  proxy  ("Proxy")  is  solicited  on  behalf  of the Board of
Directors (the "Board") of Shaman Pharmaceuticals,  Inc., a Delaware corporation
(the  "Company"),  for use at the Special Meeting of Stockholders  (the "Special
Meeting") to be held at 9:00 A.M.  Pacific  Standard  Time on Friday,  March 10,
2000,  at The  Embassy  Suites,  250  Gateway  Boulevard,  South San  Francisco,
California 94080, and at any adjournment thereof.

     This Proxy  Statement  and the  accompanying  form of Proxy are to be first
mailed to the  stockholders  entitled to vote at the Special Meeting on or about
February 9, 2000.

Record Date and Voting

     The  specific  proposals  to be  considered  and acted upon at the  Special
Meeting are  summarized  in the  accompanying  Notice and are  described in more
detail  in this  Proxy  Statement.  All  stockholders  of record at the close of
business  on  February  2, 2000 are  entitled  to notice of, and to vote at, the
Special  Meeting.  As of the close of  business  on such date,  there were _____
shares of the Company's  Common  Stock,  par value $0.001 per share (the "Common
Stock"),  outstanding and entitled to vote, held by ____ stockholders of record.
____ shares of Series C Preferred  Stock were  outstanding  and entitled to vote
and held by ____  stockholders of record,  and ____ shares of Series D Preferred
Stock were  outstanding and held by ___  stockholders of record.  Each holder of
Common  Stock as of the record  date is  entitled  to one vote for each share of
Common  Stock held by such  stockholder  as of the record  date.  Each holder of
Series C Preferred  Stock is entitled to one vote for each share of Common Stock
into which  such  share of Series C  Preferred  Stock is  convertible  as of the
record  date.  Each holder of Series D Preferred  Stock as of the record date is
entitled  to one vote for each  share of Series D  Preferred  Stock held by such
stockholder as of the record date.

     Proposal One will be decided by the  affirmative  vote of a majority of the
voting  shares  outstanding  on the record date  including  all shares of Common
Stock,  Series C Preferred Stock and Series D Preferred Stock voting together as
a single class.  Proposal Two will be decided by the  affirmative  vote of (a) a
majority of all of the Company's outstanding voting shares, including all shares
of Common Stock,  Series C Preferred Stock and Series D Preferred Stock,  voting
together as a single class, and (b) a majority of the outstanding  shares of the
Series C Preferred Stock voting as a separate class. All other matters submitted
for  stockholder  approval  at  this  Special  Meeting  will be  decided  by the
affirmative  vote of a majority of shares  present in person or  represented  by
proxy and entitled to vote on such matters. If a choice as to the matters coming
before the Special Meeting has been specified by a stockholder on the Proxy, the
shares will be voted  accordingly.  If no contrary  instructions  are given, the
shares will be voted in favor of the approval of all proposals  described in the
accompanying  Notice of Special Meeting and in this Proxy  Statement.  All votes
will be tabulated by the inspector of election  appointed  for the meeting,  who
will separately tabulate affirmative and negative votes,  abstentions and broker
non-votes (i.e.,  the submission of a Proxy by a broker


                                       1
<PAGE>


or nominee specifically  indicating the lack of discretionary  authority to vote
on the  matter).  Abstentions  and broker  non-votes  are counted as present for
purposes of determining  the presence or absence of a quorum for the transaction
of business. Abstentions will be counted towards the tabulation of votes cast on
proposals  presented  to the  stockholders  and will  have the  same  effect  as
negative  votes,  whereas  broker  non-votes will not be counted for purposes of
determining whether a proposal has been approved. However, because Proposals One
and Two require the affirmative vote of a majority of the Company's  outstanding
voting shares on the Record Date, broker non-votes with respect to both of those
particular  proposals will have the same effect as votes against the approval of
those proposals.

     Any  stockholder  or  stockholder's   representative   who,  because  of  a
disability,  may need special assistance or accommodation to allow him or her to
participate  at  the  Special  Meeting  may  request  reasonable  assistance  or
accommodation  from the Company by contacting  Investor  Relations in writing at
213 East Grand Avenue, South San Francisco,  California 94080 or by telephone at
(650) 952-7070. To provide the Company sufficient time to arrange for reasonable
assistance,  please submit such requests by February 25, 2000.

Revocability of Proxies

     Any stockholder  giving a Proxy pursuant to this solicitation may revoke it
at any time prior to its exercise by filing with the Secretary of the Company at
its principal  executive offices at 213 East Grand Avenue,  South San Francisco,
California  94080, a written notice of such  revocation or a duly executed Proxy
bearing a later date, or by attending the Special  Meeting and voting in person.

Solicitation

     The  Company  will bear the  entire  cost of  solicitation,  including  the
preparation,  assembly,  printing and mailing of the Notice of Special  Meeting,
this  Proxy  Statement,  the Proxy  and any  additional  solicitation  materials
furnished to stockholders. Copies of solicitation materials will be furnished to
brokerage houses,  fiduciaries and custodians holding shares in their names that
are  beneficially  owned by others so that they may  forward  this  solicitation
material to such beneficial  owners.  To assure that a quorum will be present in
person or by proxy at the  Special  Meeting,  it may be  necessary  for  certain
officers, directors, employees or other agents of the Company to solicit proxies
by  telephone,  facsimile  or other  means or in person.  The  Company  will not
compensate  such  individuals  for any  such  services.  The  Company  does  not
presently intend to solicit proxies other than by mail.

================================================================================
                                    IMPORTANT

Please  mark,  date,  sign and return  the  enclosed  Proxy in the  accompanying
postage-prepaid,  return envelope as soon as possible so that, if you are unable
to attend the Special Meeting, your shares may be voted.
================================================================================


                                       2
<PAGE>

                 MATTERS TO BE CONSIDERED AT THE SPECIAL MEETING

                                  PROPOSAL ONE

                  TRANSFER OF ALL OF THE ASSETS AND LIABILITIES
                          OF THE COMPANY TO SHAMAN.COM
                            IN EXCHANGE FOR SHARES OF
                           COMMON STOCK OF SHAMAN.COM

General Information About the Transaction

     The Company's  stockholders are being asked to act upon a proposed transfer
of  all  of  the  assets  and  liabilities  of  the  Company  to  the  Company's
wholly-owned subsidiary, Shaman.com, Inc, a Delaware corporation ("Shaman.com").
The Company will receive in exchange  for its assets and  liabilities  shares of
common  stock of  Shaman.com  having a value  equal to the net book value of the
assets and  liabilities  transferred.  If this  Proposal  One is  approved,  the
Company  would become a holding  company of  Shaman.com,  and  Shaman.com  would
conduct the Company's current  operations.  This corporate structure is intended
to permit  greater  flexibility in the management and financing of the Company's
business  operations,  since the Company believes that it can more easily obtain
financing of the Company's business through a privately held corporation.

Reasons for the Transfer of Assets to Shaman.com

     Until   December  1998,  the  Company  was  solely  focused  on  developing
pharmaceuticals  products  derived from tropical  plant  sources.  The Company's
pharmaceutical business model was dependent upon its ability to launch its first
pharmaceutical  product  in  1999.  As a  result  of  the  U.S.  Food  and  Drug
Administration   response  to  the  Company's   proposed   fast-track  New  Drug
Application   package  for  its  leading   pharmaceutical   product   candidate,
SP-303/Provir  and  insufficient  resources  to continue  the costly  process of
conducting a second pivotal trial which would have created  significant  delays,
the Company  restructured its business to focus on the development and marketing
of dietary  supplements.  In July 1999, the Company launched its first botanical
product SB-NSF and began marketing this product in September  1999.  SB-NSF is a
botanical  dietary  supplement to normalize  water flow in the bowel and promote
stool formation.

     The Company has incurred significant losses in each year since its founding
in  1989.  As of  September  30,  1999 the  Company's  accumulated  deficit  was
approximately $168.5 million. The Company will need to obtain additional funding
through public or private equity or debt financing,  collaborative agreements or
from other  sources to continue its research and  development  activities,  fund
operating  expenses and  commercialize its products.  The Company's  projections
show that cash on hand as of  September  30, 1999 should be  sufficient  to fund
operations at the current  level only through the first quarter of 2000.  Unless
the  Company  is   successful  in  its  effort  to  sell  or   out-license   its
pharmaceutical  products,  or to sell or establish  collaborative  agreements to
sell its botanical  products,  it will be unable to fund its current  operations
beyond the first quarter of 2000. The Company believes that as a publicly traded
company,  it will be unable to obtain adequate financing to continue  operations
and to  further  its  business  plans,  and  that  creating  a  privately  held,
wholly-owned  subsidiary  for the  Company's  operations  is  necessary  to seek
financing for the Company's  business,  since the simpler structure of a private
company will be more  attractive to outside  investors as a private  investment.
However, there can be no guarantee that Shaman.com will be successful in raising
any  financing  to be able to continue  its  operations  or further its business
plans.  In addition,  the Company's  operations  will better thrive in a private
company  unencumbered  by the  expenses  generated  by the  extensive  reporting
requirements of the federal securities laws.


                                       3
<PAGE>


Material Differences in the Rights of the Company's  Stockholders  Following the
Transfer of Assets

     The transfer of the Company's  assets and  liabilities  will not change the
ownership  rights of the  Company's  stockholders  in the  Company.  Each of the
Company's  stockholders  will still own shares of the Common  Stock or Preferred
Stock, as the case may be, of the Company and will continue with the same voting
and dividend rights as before. However, the transfer will effect a change in the
nature of each of the  Company's  stockholder's  ownership  of the assets of the
Company. Prior to the transfer, the Company directly owned all of its assets. By
transferring all of the assets to Shaman.com,  a wholly-owned  subsidiary of the
Company, the Company's  stockholders will now indirectly own such assets through
the Company's ownership of Shaman.com.  As a result of the proposed transaction,
the  stockholders  of the  Company  will not  directly  elect the  Directors  of
Shaman.com. Directors of Shaman.com will be elected by the Board of the Company,
which will be the sole  shareholder  of  Shaman.com.  The Board of  Directors of
Shaman.com  will in turn elect the  officers of  Shaman.com  and will  otherwise
control the business and affairs of  Shaman.com.  It is generally  expected that
the officers,  directors,  and other senior  management  employees of Shaman.com
will be comprised  principally  of persons also serving as officers,  directors,
and  other  senior  executives  of the  Company.  Similarly,  the  stockholders'
statutory right to inspect the books and records of the Company under applicable
Delaware  law may not extent to the books and  records of  Shaman.com.  However,
because the Company is a public company subject to the reporting requirements of
the Securities Exchange Act of 1934,  information  regarding the Company and its
subsidiary is available to stockholders without resort to the statutory right to
inspect the Company's books and records.

     In the event that the Company proposes to make a further disposition of the
stock of Shaman.com or if Shaman.com  disposes of its assets,  in either case to
an unrelated  third party or  affiliate  other than  another  subsidiary  of the
Company,  the  Company  will seek  stockholder  approval  if the stock or assets
involved  constitute  substantially  all of the assets of  Shaman.com.  For this
reason, the proposed  transaction does not alter stockholders' rights to approve
such  dispositions.  The Company has no present intention to cause Shaman.com to
make a further  transfer  of assets  (other  than a sale or  out-license  of the
Company's  pharmaceutical  assets) to an unrelated third party. The Company does
not intend to seek stockholder approval of any subsequent dispositions of assets
by Shaman.com or of the stock of  Shaman.com,  unless such assets or stock to be
transferred constitute all or substantially all of the assets of the Company and
Shaman.com as a whole.

     In the future, the Company's stockholders will experience dilution in their
indirect  ownership of Shaman.com if Shaman.com is successful in raising  equity
financing.  Currently,  Shaman.com is a wholly-owned  subsidiary of the Company.
Therefore, the stockholders of the Company indirectly own all of the outstanding
capital stock of Shaman.com.  However, Shaman.com will need to obtain additional
financing through private equity or debt financings or from other sources or may
enter into  collaborative  arrangements that involve either sales of its capital
stock or  transactions  involving an exchange of shares of its capital stock for
shares of the third  party's  capital  stock or shares of  Shaman.com's  capital
stock for certain of the third party's assets. If additional funds are raised by
issuing equity securities, the Company will no longer own all of the outstanding
capital  stock of  Shaman.com,  and the  indirect  ownership  percentage  of the
Company's stockholders will correspondingly decrease. Additionally, as employees
are hired for Shaman.com,  such employees will likely receive options to acquire
shares of  Shaman.com  common  stock.  Any such  issuance  of  options,  and the
subsequent exercise thereof,  would dilute the Company's  stockholders' indirect
ownership  interest  in  Shaman.com.  The  Company  and  Shaman.com  may  not be
successful in raising equity or debt financing.


                                       4
<PAGE>


Effect on Company's Financial Statements

     The  implementation  of Proposal One will not have a material effect on the
financial  statements  of the  Company.  The  Company  will  however  report its
financial  operations and condition on a consolidated  basis.  The net income of
Shaman.com,   reflected  as  income  on  the  Company's  consolidated  financial
statements,  will be available for the payment of dividends to  stockholders  of
the  Company to the extent  that the Company  has  received  dividends  or other
distributions from Shaman.com.

Financial Accounting Implications

     For financial  accounting and reporting purposes,  Shaman.com will be fully
consolidated with the Company, and this transaction is not expected to otherwise
have any material financial reporting implications for the Company.

Federal Tax Consequences

     Following is a summary of the material  federal income tax  consequences of
the proposed transfer of the Company's assets to Shaman.com (the "Transaction").
The summary does not purport to discuss all potential tax issues or consequences
of the  Transaction.  In addition,  no summary is provided as to (1) any federal
income tax  consequences  other than as  expressly  set forth herein and (2) any
state and local tax consequences.

     The facts  relevant to this  summary are set forth in this Proxy  Statement
and related  documents.  This summary is based on the  Internal  Revenue Code of
1986, as amended (the "Code"), the income tax regulations issued by the Internal
Revenue  Service  (the  "IRS"),   including   temporary  and  proposed  Treasury
regulations  ("Treas.  Reg."),  administrative  rulings of the IRS, and judicial
decisions  as of the date of this Proxy  Statement - all of which are subject to
change at any time either  prospectively  or  retroactively.  In some cases, the
proper  interpretation  of such  authorities or their  application to particular
factual situations is unclear.

Capitalization of Shaman.com

     The Company  proposes  the transfer of all of its assets to  Shaman.com  in
exchange for (a) all of the issued and  outstanding  voting stock of  Shaman.com
and  (b) the  assumption  by  Shaman.com  of all of the  Company's  liabilities.
Section 351 of the Code  provides  that no "gain or loss shall be  recognized if
property is  transferred  to a  corporation...solely  in  exchange  for stock or
securities  in  such   corporation"  and  immediately  after  the  exchange  the
transferor   "controls"   the   corporation  to  which  the  property  has  been
transferred. The statute, in short, renders non-taxable transfers of property in
exchange for a proprietary  interest in a controlled  corporation.  Accordingly,
except to the extent that the Company's liabilities assumed by Shaman.com exceed
the Company's  adjusted basis in the assets it transfers to Shaman.com,  no gain
or loss should be recognized by the Company as a result of the Transaction. Code
sections  351(a)  and 357  (c)(1).  Shaman.com  will  realize no gain or loss by
reason of the  Transaction.  Code  sections  351(a)  and  118(a).  Even were the
Company  to  recognize  gain  on  the  transaction  by  reason  of  Shaman.com's
assumption of the  Company's  liabilities,  the  Company's net operating  losses
might be sufficient to offset any such gain.

Shaman.com's Basis in its Assets

     Shaman.com's  basis in the assets transferred to it will be the same as the
Company's  basis  in  those  assets  increased  by the  amount  of gain (if any)
recognized by the Company. Code section 362(a).


                                       5
<PAGE>


Consolidated Returns

     Because the Company  will possess at least 80% of the total voting power of
the stock of Shaman.com,  the Company and  Shaman.com  constitute an "affiliated
group" of corporations  eligible to file  consolidated  federal corporate income
tax returns.  Code ss. 1501 and 1504 (a)(1) and (2). The issuance of  additional
Shaman.com  shares to third parties could cost the Company and Shaman.com  their
"affiliated  group"  status  and with it the  privilege  of filing  consolidated
returns.

Rights of Dissenting Stockholders

     If the  proposed  transfer  of all of the  assets  and  liabilities  of the
Company to Shaman.com is  consummated,  a stockholder  objecting to the terms of
the proposed  transaction or voting against  Proposal One is not entitled to any
appraisal or similar rights under Delaware or California law.

Vote Required for Stockholder Approval

     The affirmative vote of a majority of all shares the Company's  outstanding
voting  shares is required for approval of the transfer of all of the assets and
liabilities  of the Company to Shaman.com in exchange for shares of common stock
of Shaman.com.

Recommendation of the Board of Directors

     The Board recommends that the stockholders vote IN FAVOR OF the transfer of
all of the assets and  liabilities  of the Company to Shaman.com in exchange for
shares of common stock of Shaman.com.

     The Board has carefully  considered  the benefits and risks of the proposed
transaction described in this Proposal One and believes that the Company and its
stockholders will benefit from the increased potential ability of Shaman.com, as
a privately  held company,  to raise capital to maintain  operations and further
its business plan and work to increase the value of its assets.


                                       6
<PAGE>


                                  PROPOSAL TWO

                                AMENDMENT TO THE
             COMPANY'S CERTIFICATE OF INCORPORATION TO AMEND CERTAIN
                LIQUIDATION PREFERENCE RIGHTS OF PREFERRED STOCK


     The Board has adopted a resolution proposing and declaring the advisability
of amending  Article IV,  Section B.5 (e) of the Company's  Amended and Restated
Certificate of Incorporation  to amend the provision  stating that a sale of all
or  substantially  all of the  assets  of  the  Company  will  be  treated  as a
liquidation, dissolution or winding up of the Company. The proposed amendment to
Section B.5 (e) provides that a sale or transfer of all or substantially  all of
the assets of the Company to any entity other than a  subsidiary  of the Company
will be treated as a liquidation,  dissolution or winding up of the Company.  If
approved by the  Company's  stockholders  as provided  herein,  the amendment to
Section  B.5 (e) will be  effected  by an  amendment  to Section  B.5 (e) of the
Company's Amended and Restated Certificate in substantially the form attached to
this Proxy Statement as Exhibit A which will become effective upon the filing of
the amendment with the Secretary of State of Delaware.  The following discussion
is  qualified  in its  entirety  by the  full  text of the  amendment,  which is
incorporated by reference herein.

Currently,  this  section of the Amended and  Restated  Certificate  provides as
follows:

     "With respect to the Series A Preferred Stock, Series C Preferred Stock and
Series D Preferred  Stock  (except as limited with respect to Series D Preferred
Stock  as set  forth  in  Section  5 (b)  above),  (i)  any  acquisition  of the
Corporation  by means of merger or other  form of  corporate  reorganization  in
which  outstanding  shares of the  Corporation  are exchanged for  securities or
other consideration issued, or caused to be issued, by the acquiring corporation
or its subsidiary (other than a mere reincorporation transaction) or (ii) a sale
of all or substantially  all of the assets of the Corporation or (iii) any other
transaction  or series of related  transactions  by the  Corporation in which in
excess of 50% of the Corporation's voting power is transferred, shall be treated
as a liquidation, dissolution or winding up of the Corporation and shall entitle
the  holders of the Series C  Preferred  to receive at the  closing  thereof the
amount as specified in Section 5 (a) and Section 5 (c), respectively."

     Stockholders  are being asked to vote on a proposal to amend subclause (ii)
of this section.  The effect of this amendment  would be that a sale or transfer
by the Company of all or substantially  all of its assets to a subsidiary (as in
the case of Proposal One) would not be treated as a liquidation  event, and that
such  transaction   would  therefore  not  result  in  a  requirement  that  the
liquidation  preference  amounts of the preferred  stock be  distributed  to the
holders of Series C Preferred  Stock.  The amendment of subclause  (ii) will not
affect the  holders of Series D  Preferred  Stock  since  Section B.5 (b) of the
Amended  and  Restated  Certificate  provides  that  sales or  transfers  of the
Company's assets are not considered in and of themselves as a liquidation  event
for holders of Series D Preferred Stock.

Reasons for the Amendment

     The proposed  amendment would avoid having a transfer or sale of all of the
assets of the Company to a subsidiary of the Company  cause a liquidation  event
under the Amended and  Restated  Certificate  that would  require the Company to
distribute  to the  holders  of  Series  C  Preferred  Stock  their  liquidation
preference  amounts.  If the Company  effects the  transaction  contemplated  in
Proposal  One, the Company could be required to pay the  liquidation  amounts in
cash to its Series C Preferred  Stock  holders.  The  Company  does not have the
financial  resources to pay the  liquidation  preference  amounts,  and any such
required  payment  would  therefore  be  detrimental  to  the  Company  and  its
stockholders.  The  possibility  that the  transfer  of all of the assets of the
Company to its wholly-owned  subsidiary could result in requiring the


                                       7
<PAGE>


Company  to  distribute  the  Series  C  preferred   stockholders'   liquidation
preference  amounts  would make it  impossible to proceed with Proposal One, and
the Board believes it is necessary and in the best interests of its stockholders
to avoid this possibility.  Proposal One would permit greater flexibility in the
financing of new and existing  business  operations  and the  formation of joint
ventures or other business combinations with third parties.

Vote Required for Stockholder Approval

     The affirmative vote of (a) a majority of all of the Company's  outstanding
voting shares,  including all shares of Common Stock,  Series C Preferred  Stock
and Series D  Preferred  Stock,  voting  together as a single  class,  and (b) a
majority  of the  outstanding  shares of Series C  Preferred  Stock  voting as a
separate  series,  is  required  to approve  the  amendment  of the  Amended and
Restated  Certificate to amend  subclause (ii) of Article IV, Section B.5 (e) of
the Amended and Restated  Certificate  to provide that a sale or transfer of all
or  substantially  all of the assets to an entity other than a subsidiary of the
Company  will be  treated  as a  liquidation,  dissolution  or winding up of the
Company.

Recommendation of the Board of Directors

     The Board of Directors  recommends that the  stockholders  vote IN FAVOR OF
the   amendment  of  the   Company's   Amended  and  Restated   Certificate   of
Incorporation.  The fact that a transfer  of all of the assets of the Company to
its wholly-owned  subsidiary could result in requiring the Company to distribute
the Series C Preferred Stock holders'  liquidation  preference amount would make
it impossible  to proceed with Proposal One if approved,  since the Company does
not have the financial resources to pay the liquidation preference amounts.


                                       8
<PAGE>

                             ADDITIONAL INFORMATION

         SECURITY OWNERSHIP OF MANAGEMENT AND CERTAIN BENEFICIAL OWNERS

     The following table sets forth certain information known to us with respect
to the beneficial  ownership of the common stock and Series R Preferred Stock as
of  December  15,  1999 by (1) all  persons  who are  beneficial  owners of five
percent or more of the common stock or Series R Preferred  Stock, as applicable,
(2) each  director  and  officer of Shaman  and (3) all  current  directors  and
executive  officers as a group. The number of shares  beneficially owned by each
director  or  executive  officer is  determined  under  rules of the SEC and the
information is not necessarily  indicative of beneficial ownership for any other
purpose.  Shares of common  stock or Series R Preferred  Stock,  as  applicable,
subject to options or warrants  currently  exercisable or exercisable  within 60
days of  December  15, 1999 are  included  in the number of shares  beneficially
owned by the person  holding such option or warrant for computing the percentage
ownership of such person,  but are not treated as outstanding  for computing the
percentage of any other person.  Except as otherwise indicated,  we believe that
the beneficial  owners of the common stock and Series R Preferred Stock,  listed
below,  based upon such information  furnished by such owners,  have sole voting
and investment power with respect to such shares,  subject to community property
laws where applicable.

<TABLE>
<CAPTION>
- --------------------------------------------------------------------------------------------------------
 Name and Address of                     Shares of Common Stock       Series R Preferred Stock
     Beneficial Owner(1)                         Owned                      Shares Owned(3)
- --------------------------------------------------------------------------------------------------------
                                                Number           Percent(2)    Number          Percent(2)
- -------------------------------------------------------------------------------------------------------
<S>                                        <C>                      <C>      <C>                 <C>
Vulcan Ventures, Inc.                        5,459,812(4)           8.01%    118,596(5)           15.10%
110-110th Avenue NW,  Suite 550
Belleview, WA  98084
- -------------------------------------------------------------------------------------------------------
Lipha S.A.                                      87,247               *       133,334              17.16%
37 rue Saint-Romain
69379 Lyon cedex 08
- -------------------------------------------------------------------------------------------------------
H. Reisman Corporation                               0               *        67,862               8.73%
P.O. Box 759
377 Crane Street
Orange, NJ 07051
- -------------------------------------------------------------------------------------------------------
Lisa A. Conte                                   23,110               *        36,626(6)            4.50%
- -------------------------------------------------------------------------------------------------------
John W.S. Chow                                       0               *         3,167(7)                *
- -------------------------------------------------------------------------------------------------------
Thomas Carlson, M.D.                                 0               *         7,483(8)                *
- -------------------------------------------------------------------------------------------------------
Steven R. King, Ph.D.                              763               *        10,917(9)            1.39%
- -------------------------------------------------------------------------------------------------------
Gerald R. Reaven, M.D.                              25               *         1,195(10)                *
- -------------------------------------------------------------------------------------------------------
Tom White                                           25               *         2,251(11)                *
- -------------------------------------------------------------------------------------------------------
Adrian D.P. Bellamy                                  0               *         8,262(12)           1.05%
- -------------------------------------------------------------------------------------------------------
Jeffrey Berg                                         0               *         5,736(13)                *
- -------------------------------------------------------------------------------------------------------
Loren D. Israelsen                                  45               *        24,736(14)           3.16%
- -------------------------------------------------------------------------------------------------------
Herbert McDade, Jr.                                  0               *         6,069(15)                *
- -------------------------------------------------------------------------------------------------------
G. Kirk Raab                                   397,457(16)           *        13,998(17)           1.77%
- -------------------------------------------------------------------------------------------------------
M. David Titus                                     250               *         7,269(18)                *
- -------------------------------------------------------------------------------------------------------
Directors and officers as a group              421,610               *       127,709(19)          14.50%
- -------------------------------------------------------------------------------------------------------
</TABLE>

*    Less than 1.0%


                                       9
<PAGE>


(1) This table is based upon information  supplied to us by executive  officers,
directors and  stockholders  owning  greater than five percent,  as set forth in
filings  required by the  Securities  and  Exchange  Commission  or as otherwise
provided.  The address of each officer and director  identified in this table is
that of Shaman's executive offices,  213 East Grand Avenue, South San Francisco,
CA 94080.

(2) Percentage of beneficial  ownership is calculated assuming 68,135,451 shares
of common stock were  outstanding as of December 15, 1999, and 777,101 shares of
Series R Preferred  Stock were  outstanding as of December 15, 1999.  Beneficial
ownership is  determined  in  accordance  with the rules of the  Securities  and
Exchange  Commission  and generally  includes  voting or  investment  power with
respect to securities.  Shares of common stock or Series R Preferred  Stock,  as
applicable, subject to options and warrants currently exercisable or exercisable
within 60 days of  December  15,  1999,  are  included  in the  number of shares
outstanding  for computing the  percentage of the person  holding such option or
warrant but are not included in the number of shares  outstanding  for computing
the percentage of any other person.

(3) The  Company's  Series R  Preferred  Stock  will  automatically  convert  on
February 1, 2000 into a number of shares of Common Stock equal to $15.00 divided
by the conversion  price then in effect.  The conversion price shall be equal to
the lesser of $0.10 per share,  or the price that is equal to 10% of the average
closing  sales price of the common  stock for the 10 trading  days ending  three
trading days prior to February 1, 2000.  However,  the Series R Preferred  Stock
will  convert on  February  1, 2000 only to extent  that the  Company has enough
common  stock  shares  authorized  to issue all shares of common stock needed to
effect the conversion of all outstanding shares of the Series R Preferred Stock,
after taking into account the number of common stock shares  necessary to effect
the conversion of any then  outstanding  shares of Series C Preferred  Stock and
Series D Preferred Stock. Based on a conversion price of $0.002,  which is equal
to 10% of the average  closing  price of the  Company's  Common Stock for the 10
trading  days  ending  three  trading  days  prior to  December  15,  1999,  the
outstanding  shares of Series R Preferred  Stock and  outstanding  warrants  and
options would be convertible into 8,294,107,500 shares of Common Stock.

(4) Does  not  include  20,000  shares  of  Series C  Preferred  Stock  which is
convertible  to a certain  number of shares of common  stock,  such number which
shall be determined in accordance  with Shaman's  certificate of  incorporation.
The certificate of incorporation  prohibits conversion of the Series C Preferred
Stock  to the  extend  such  conversion  would  cause  the  holder's  beneficial
ownership  of Common  Stock to exceed 4.9% of the  outstanding  shares of Common
Stock.

(5) Includes 8,333 shares issuable upon exercise of outstanding  warrants within
60 days of December 15, 1999.

(6) Includes  2,500 shares  issuable upon exercise of  outstanding  warrants and
33,459 shares of issuable  upon  exercise of options  within 60 days of December
15, 1999.

(7) Includes 667 shares issuable upon exercise of outstanding warrants and 2,500
shares of issuable upon exercise of options within 60 days of December 15, 1999.

(8) Includes 400 shares issuable upon exercise of outstanding warrants and 7,083
shares of issuable upon exercise of options within 60 days of December 15, 1999.

(9) Includes  500 shares  issuable  upon  exercise of  outstanding  warrants and
10,417 shares of issuable  upon  exercise of options  within 60 days of December
15, 1999.

(10)  Represents  shares of issuable upon exercise of options  within 60 days of
December 15, 1999.

(11) Includes  2,151 shares of issuable upon exercise of options  within 60 days
of December 15, 1999.

(12)  Includes 833 shares  issuable upon  exercise of  outstanding  warrants and
5,736 shares of issuable upon exercise of options within 60 days of December 15,
1999.

(13)  Represents  shares of issuable upon exercise of options  within 60 days of
December 15, 1999.

(14) Includes 19,000 shares held by LDI Group,  of which Mr.  Israelsen owns 80%
and 5,736 shares  issuable upon  exercise of options  within 60 days of December
15, 1999.

(15)  Includes 333 shares  issuable upon  exercise of  outstanding  warrants and
5,736 shares of issuable upon exercise of options within 60 days of December 15,
1999.

(16)  Does not  include  1,500  shares  of  Series C  Preferred  Stock  which is
convertible  to a certain  number of shares of common  stock,  such number which
shall be determined in accordance  with Shaman's  certificate of  incorporation.
The certificate of incorporation  prohibits conversion of the Series C Preferred
Stock  to the  extend  such  conversion  would  cause  the  holder's  beneficial
ownership  of Common  Stock to exceed 4.9% of the  outstanding  shares of Common
Stock.


                                       10
<PAGE>


(17)  Includes 833 shares  issuable upon  exercise of  outstanding  warrants and
11,472 shares of issuable  upon  exercise of options  within 60 days of December
15, 1999.

(18)  Includes 833 shares  issuable upon  exercise of  outstanding  warrants and
5,736 shares of issuable upon exercise of options within 60 days of December 15,
1999.

(19)  Represents  total shares held by  directors  and  officers  listed  above.
Includes 6,899 shares issuable upon exercise of outstanding  warrants and 96,957
shares of issuable upon exercise of options within 60 days of December 15, 1999.



                                       11
<PAGE>

                                  OTHER MATTERS

     The Board knows of no other business which will be presented at the Special
Meeting.  If any other business is properly  brought before the Special Meeting,
it is  intended  that  proxies  in the  enclosed  form will be voted in  respect
thereof in accordance with the judgment of the persons voting the proxies.

     It is important that the proxies be returned  promptly and that your shares
be  represented.  Stockholders  are urged to mark,  date,  execute and  promptly
return the accompanying proxy card in the enclosed envelope.



By Order of the Board of Directors,



Lisa A. Conte,
President and Chief Executive Officer,
Chief  Financial Officer and Director


February _, 2000
South San Francisco, California



                                       12
<PAGE>



                                    EXHIBIT A

                    AMENDMENT TO ARTICLE IV, SECTION B.5 (e)
                       OF THE CERTIFICATE OF INCORPORATION
        TO AMEND CERTAIN LIQUIDATION PREFERENCE RIGHTS OF PREFERRED STOCK


     The following are the  resolutions of the Board of Directors  regarding the
amendment to the  Certificate  of  Incorporation  amending  certain  liquidation
preference rights of preferred stock:

     RESOLVED,  that the subclause (ii) of Article IV, of Section B.5 (e) of the
Restated and Amended  Certificate of  Incorporation  of Shaman  Pharmaceuticals,
Inc. is hereby amended to read in its entirety as follows so as to amend certain
liquidation  preference  rights of preferred stock in the event of a sale of all
or  substantially  all of the assets of the  corporation  to a subsidiary of the
corporation:

          "(ii)  a sale  of  all or  substantially  all  of  the  assets  of the
     Corporation to any entity other than a subsidiary of the Corporation or."



                                       13
<PAGE>


                          SHAMAN PHARMACEUTICALS, INC.
                                      PROXY

                 Special Meeting of Stockholders, March 10, 2000

         This Proxy is Solicited on Behalf of the Board of Directors of
                          Shaman Pharmaceuticals, Inc.


     The undersigned revokes all previous proxies,  acknowledges  receipt of the
Notice of the Special  Meeting of  Stockholders to be held on March 10, 2000 and
the Proxy  Statement  and appoints  Lisa A. Conte and G. Kirk Raab,  and each of
them, the Proxy of the undersigned, with full power of substitution, to vote all
shares of Common Stock or Preferred Stock of Shaman  Pharmaceuticals,  Inc. (the
"Company")  which the undersigned is entitled to vote,  either on his or her own
behalf  or on behalf  of any  entity or  entities,  at the  Special  Meeting  of
Stockholders  of the  Company  to be held at The  Embassy  Suites,  250  Gateway
Boulevard, South San Francisco,  California,  94080 on Friday, March 10, 2000 at
9:00 A.M. Pacific Standard Time (the "Special Meeting"),  and at any adjournment
or postponement thereof, with the same force and effect as the undersigned might
or could do if personally present thereat.  The shares represented by this Proxy
shall be voted in the manner set forth on the reverse side.

     1.   |_| FOR |_| AGAINST |_| ABSTAIN To approve the  transfer of all of the
          assets and liabilities of Shaman Pharmaceuticals,  Inc. to Shaman.com,
          Inc.  ("Shaman.com")  in  exchange  for  shares  of  Common  Stock  of
          Shaman.com;

     2.   |_| FOR |_| AGAINST |_| ABSTAIN To approve an amendment to the Amended
          and Restated  Certificate to delete the provision  stating that a sale
          of all or substantially  all of the assets the Company will be treated
          as a  liquidation,  dissolution  or  winding  up of the  Company,  for
          purposes of causing a required liquidation preference  distribution to
          the holders of Series C Preferred Stock; and

     3.   To  transact  such other  business  as may  properly  come  before the
          Special Meeting and any adjournment or postponement thereof.

     The Board of Directors  recommends a vote IN FAVOR OF each of the proposals
listed above.  This Proxy,  when properly  executed,  will be voted as specified
above. If no specification is made, this Proxy will be voted IN FAVOR OF each of
the proposals listed above.

     Please print the name(s) appearing on each share  certificate(s) over which
you have voting authority: _______________________________________________
                                   (Print name(s) on certificate)

Please sign your name: _____________________________________ Date: ___________
                           (Authorized Signature(s))




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