SHAMAN PHARMACEUTICALS INC
SC 13D/A, 2000-02-03
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549










                                 ---------------

                                 SCHEDULE 13D/A

                    Under the Securities Exchange Act of 1934

                                (Amendment No. 1)

                                 ---------------

                          SHAMAN PHARMACEUTICALS, INC.
                                (Name of Issuer)

                                  COMMON STOCK
                         (Title of Class of Securities)

                                    819319 10
                                 (CUSIP Number)

    William D. Savoy                            Gail J. Gordon
    Vulcan Ventures Incorporated                Foster Pepper & Shefelman PLLC
    110-110th Avenue N.E., Suite 550            1111 Third Avenue, Suite 3400
    Bellevue, WA  98004                         Seattle, WA  98101
    (206) 453-1940                              (206) 447-4400

(Name, Address and Telephone Number of Persons Authorized to Receive Notices and
Communications)

                                January 31, 2000
             (Date of Event which Requires Filing of This Statement)

                                 ---------------

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule because of ss.ss.  240.13d-1(e),  240.13d-1(f) or 240.13nd-1(g),  check
the following box. |_|

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the  schedule  including  all  exhibits.  See  ss.240.13d-7  for other
parties to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

<PAGE>

- --------------------------                             ------------------------
 CUSIP NO.  819319 10                  13D              Page 2 of 7 Pages
            ---------
- --------------------------                             ------------------------

- --------------------------------------------------------------------------------
 1   NAME OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

             Vulcan Ventures Incorporated
- --------------------------------------------------------------------------------
 2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) |_|
                                                               (b) |_|
- --------------------------------------------------------------------------------
 3   SEC USE ONLY


- --------------------------------------------------------------------------------
 4   SOURCE OF FUNDS*

          WC
- --------------------------------------------------------------------------------
 5   CHECK BOX  IF  DISCLOSURE  OF  LEGAL  PROCEEDINGS  IS REQUIRED  PURSUANT TO
     ITEMS 2(d) OR 2(E)

- --------------------------------------------------------------------------------
 6   CITIZENSHIP OR PLACE OF ORGANIZATION

        State of Washington
- --------------------------------------------------------------------------------
   NUMBER OF      7    SOLE VOTING POWER
    SHARES                         0 shares
 BENEFICIALLY   ----------------------------------------------------------------
   OWNED BY       8    SHARED VOTING POWER
     EACH                          3,674,476 shares(1)
   REPORTING    ----------------------------------------------------------------
    PERSON        9    SOLE DISPOSITIVE POWER
     WITH                          0 shares
                ----------------------------------------------------------------
                  10   SHARED DISPOSITIVE POWER
                                   3,674,476 shares(1)
- --------------------------------------------------------------------------------
 11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          3,674,476(1)
- --------------------------------------------------------------------------------
 12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*


- --------------------------------------------------------------------------------
 13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          11.9%
- --------------------------------------------------------------------------------
 14  TYPE OF REPORTING PERSON*

          CO
- --------------------------------------------------------------------------------
- ---------------
(1) Directly owned by Vulcan  Ventures  Incorporated.  Paul G. Allen is the sole
shareholder  of Vulcan  Ventures  Incorporated  and may be deemed to have shared
voting and dispositive power with respect to such shares.

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>

- --------------------------                             ------------------------
 CUSIP NO.  819319 10                  13D              Page 3 of 7 Pages
            ---------
- --------------------------                             ------------------------

- --------------------------------------------------------------------------------
 1   NAME OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

             Paul G. Allen
- --------------------------------------------------------------------------------
 2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) |_|
                                                               (b) |_|
- --------------------------------------------------------------------------------
 3   SEC USE ONLY


- --------------------------------------------------------------------------------
 4   SOURCE OF FUNDS*

          AF
- --------------------------------------------------------------------------------
 5   CHECK BOX  IF  DISCLOSURE  OF  LEGAL  PROCEEDINGS  IS REQUIRED  PURSUANT TO
     ITEMS 2(d) OR 2(E)


- --------------------------------------------------------------------------------
 6   CITIZENSHIP OR PLACE OF ORGANIZATION

        United States of America
- --------------------------------------------------------------------------------
   NUMBER OF      7    SOLE VOTING POWER
    SHARES                         0 shares
 BENEFICIALLY   ----------------------------------------------------------------
   OWNED BY       8    SHARED VOTING POWER
     EACH                          3,674,476 shares(1)
   REPORTING    ----------------------------------------------------------------
    PERSON        9    SOLE DISPOSITIVE POWER
     WITH                          0 shares
                ----------------------------------------------------------------
                  10   SHARED DISPOSITIVE POWER
                                   3,674,476 shares(1)
- --------------------------------------------------------------------------------
 11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          3,674,476 shares(1)
- --------------------------------------------------------------------------------
 12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*


- --------------------------------------------------------------------------------
 13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          11.9%
- --------------------------------------------------------------------------------
 14  TYPE OF REPORTING PERSON*

          IN
- --------------------------------------------------------------------------------
- ---------------
(1) Directly owned by Vulcan  Ventures  Incorporated.  Paul G. Allen is the sole
shareholder  of Vulcan  Ventures  Incorporated  and may be deemed to have shared
voting and dispositive power with respect to such shares.

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>

Introductory Note
- -----------------

     This Amendment No. 1 (the "Amendment") amends and supplements the statement
on Schedule  13D,  filed by Vulcan  Ventures  Incorporated  and Paul G. Allen on
January 27, 2000,  relating to the common stock, $0.001 par value per share (the
"Common Stock"), of Shaman  Pharmaceuticals,  Inc., a Delaware  corporation (the
"Issuer").  Except as  otherwise  stated,  amounts  set forth in this  statement
reflect a one-for-fifty  reverse split of the outstanding Common Stock as of the
close of business on January 31, 2000 and the automatic conversion of each share
of the Issuer's Series R Stock into 31 shares of Common Stock (on a post-reverse
split basis) on February 1, 2000.

     Only those items amended are reported herein. Capitalized terms not defined
herein have the meaning ascribed to them in the Schedule 13D.

Item 5.  Interest in Securities of the Issuer
- -------  ------------------------------------

     On February 1, 2000, the 110,263 shares of Series R Stock held of record by
Vulcan Ventures  automatically  converted into 3,418,153 shares of Common Stock.
Therefore,   as  of  the  date  hereof,  Vulcan  Ventures  owns  of  record  and
beneficially  20,000 shares of the Issuer's Series C Stock and 3,418,153  shares
of  Common  Stock.  In  addition,   assuming  exercise  of  Warrants  originally
exercisable  for shares of the Issuer's  Series R Stock and now  exercisable for
shares of Common  Stock at a price of $0.497 per share  until  August 23,  2002,
Vulcan  Ventures  may be deemed to own an  additional  258,323  shares of Common
Stock.  Therefore,  the  aggregate  number of shares of Common Stock that Vulcan
Ventures may be deemed  beneficially  to own is 3,676,476  shares,  representing
approximately 11.9% of the Common Stock outstanding as of February 1, 2000. This
percentage is based upon  30,491,643  shares of Common Stock  outstanding  as of
February 1, 2000, as reported to Vulcan Ventures by the Issuer.  (That number is
subject to upward  adjustment  for  rounding  in  connection  with the  Issuer's
reverse split as of January 31, 2000 and the automatic  conversion of the Series
R Stock.) The Issuer's Certificate of Incorporation  prohibits conversion of the
Series C  Preferred  to the extent  such  conversion  would  cause the  holder's
beneficial ownership of Common Stock to exceed 4.9% of the outstanding shares of
Common  Stock.  Therefore,  the shares of Common  Stock into which the Series C
Stock held by Vulcan Ventures is convertible are not deemed  beneficially  owned
by Vulcan Ventures or Mr. Allen.

     As the sole  shareholder  of Vulcan  Ventures,  Mr. Allen shares voting and
dispositive  power with Vulcan Ventures over the shares of the Issuer's  capital
stock  owned  by  Vulcan  Ventures.  Therefore,  Mr.  Allen  may be  deemed  the
beneficial owner of such shares.

     To the best knowledge of Vulcan  Ventures and Mr. Allen,  none of the other
parties named in Item 2 owns any of the Issuer's common stock.

     Since the date on which the Schedule 13D was filed, Vulcan Ventures and Mr.
Allen have sold an  aggregate of 5,459,812  shares  pre-reverse  split of Common
Stock  in  over-the-counter  transactions  at the  following  pre-reverse  split
prices:

         ----------------- ------------------------- -----------------------
                           Number of Shares of       Gross Sales
         Date              Common Stock              Price Per Share
         ----------------- ------------------------- -----------------------
         1/28/99                    200,000                  .0990
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                     60,000                  .1090
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    140,000                  .1100
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    185,000                  .1150
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                     40,000                  .1180
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                     55,000                  .1200
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                     10,000                  .1250
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    100,000                  .1260
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                     10,000                  .1270
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    200,000                  .1300
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    400,000                  .1350
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    100,000                  .1400
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    200,000                  .1480
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
         1/31/00                    250,000                  .0590
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    250,000                  .0600
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    509,812                  .0610
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    150,000                  .0625
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    100,000                  .0640
         ----------------- ----------------- ------- -------------- --------

                                  Page 4 of 7
<PAGE>
         ----------------- ----------------- ------- -------------- --------
                                    250,000                  .0680
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    150,000                  .0700
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    100,000                  .0720
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    750,000                  .0740
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    500,000                  .0750
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    250,000                  .0760
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    100,000                  .0780
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    150,000                  .0790
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                    220,000                  .0800
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                     10,000                  .0900
         ----------------- ----------------- ------- -------------- --------
         ----------------- ----------------- ------- -------------- --------
                                     20,000                  .0950
         ----------------- ----------------- ------- -------------- --------

     Except as set forth in this  statement,  Vulcan Ventures and Mr. Allen have
not, nor, to the knowledge of Vulcan Ventures has any of its executive officers,
directors or  controlling  persons,  effected any  transactions  in the Issuer's
common stock during the past sixty days.

Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to
        Securities of the Issuer.
- ------- ------------------------------------------------------------------------

     Except as set forth in this statement, Vulcan Ventures and Mr. Allen do not
have,  nor,  to the  knowledge  of  Vulcan  Ventures  does any of the  executive
officers,  directors  or  controlling  persons  of  Vulcan  Ventures  have,  any
contracts,  arrangements,  understandings or relationships  (legal or otherwise)
with any person with respect to any  securities  of the Issuer,  finder's  fees,
joint ventures, loan or option agreements, puts or calls, guarantees of profits,
division of profits or loss, or the giving or withholding of proxies.

Item 7.  Material To Be Filed as Exhibits.
- -------  --------------------------------

         Exhibit           Description
         -------           -----------

           99.1            Joint Filing Agreement  (Incorporated by reference to
                           the Reporting Persons' Schedule 13D filed January 27,
                           2000 with respect to the Issuer's securities.)
           99.2            Power of Attorney filed on  August 30, 1999, with the
                           Schedule 13G  of  Vulcan  Ventures,  Incorporated and
                           Paul G. Allen  for  Pathogenesis,  Inc. (Incorporated
                           herein by reference.)

                                  Page 5 of 7
<PAGE>
                                   SIGNATURES

     After  reasonable  inquiry and to the best of my  knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.


                                    VULCAN VENTURES INCORPORATED





     February 2, 2000                By:      /s/ William D. Savoy
                                        ----------------------------------------
                                        William D. Savoy, Vice President


     February 2, 2000                                   *
                                     -------------------------------------------
                                     Paul G. Allen


                                     *By:     /s/ William D. Savoy
                                         ---------------------------------------
                                      William  D. Savoy as  Attorney-in Fact for
                                      Paul G.  Allen  pursuant  to  a  Power  of
                                      Attorney  filed on  August 30,  1999, with
                                      the  Schedule  13G  of  Vulcan  Ventures,
                                      Incorporated and Paul G. Allen for
                                      Pathogenesis, Inc. and incorporated herein
                                      by reference.

                                  Page 6 of 7
<PAGE>

                                  EXHIBIT INDEX


         Exhibit           Description

           99.1            Joint Filing Agreement  (Incorporated by reference to
                           the Reporting Persons' Schedule 13D filed January 27,
                           2000 with respect to the Issuer's securities.)

           99.2            Power of Attorney filed on August 30, 1999, with  the
                           Schedule 13G of  Vulcan  Ventures,  Incorporated  and
                           Paul G. Allen  for  Pathogenesis,  Inc. (Incorporated
                           herein by reference.)

                                  Page 7 of 7


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