UNITED STATES SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549
FORM 4
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP
( ) Check this box if no longer subject to Section 16.
1. Name and Address of Reporting Person
Dubin, Steve
14240 TRIDELPHIA ROAD
Glenelg, MD 21737
2. Issuer Name and Ticker or Trading Symbol
Martek Biosciences Corporation (MATK)
3. IRS or Social Security Number of Reporting Person (Voluntary)
4. Statement for Month/Year
4/2000
5. If Amendment, Date of Original (Month/Day/Year)
6. Relationship of Reporting Person(s) to Issuer (Check all applicable)
( ) Director ( ) 10% Owner
(X) Officer (give title below) ( ) Other (specify below)
Officer
7. Individual or Joint/Group Filing (Check Applicable Line)
(X) Form filed by One Reporting Person
( ) Form filed by More than One Reporting Person
<TABLE>
TABLE I -- Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
<CAPTION>
+---------------------------------+----------+-------------+-----------------------------+----------------+-----------+------------+
|1. Title of Security |2. Trans- |3. Trans- |4. Securities Acquired (A) |5. Amount of |6. Owner- |7. Nature |
| | action | action | or Disposed of (D) | Securities | ship | of In- |
| | Date | Code | | Beneficially | Form: | direct |
| | | | | Owned at | Direct | Bene- |
| | (Month/ | | | End of | (D) or | ficial |
| | Day/ +-------+-----+-----------+------+----------+ Month | Indirect| Owner- |
| | Year) |Code |V |Amount |A/D |Price | | (I) | ship |
+---------------------------------+----------+-------+-----+-----------+------+----------+----------------+-----------+------------+
<S> <C> <C> <C> <C> <C> <C> <C> <C> <C>
Common Stock 04/04/2000 M 10000 A $6.250000 D
Common Stock 04/04/2000 S -10000 D $15.156300 D
Common Stock 04/10/2000 M 10000 A $6.250000 D
Common Stock 04/10/2000 S -10000 D $15.812500 73500 D
</TABLE>
<PAGE>
<TABLE>
TABLE II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned
<CAPTION>
+-------------+--------+----------+---------+-----------+---------------------+----------------+----------+--------+-------+-------+
|1. |2. |3. |4. |5. |6. |7. |8. |9. |10. |11. |
| | | | | | | | |Number |Owner- | |
| | | | | | | | |of |ship | |
| | | | | | | | |Deriv- |Form of| |
| | | | | | |Title and Amount| |ative |Deriv- | |
| | | | | | |of Underlying | |Secur- |ative |Nature |
| |Conver- | | |Number of | |Securities | |ities |Secur- |of |
| |sion or | | |Derivative |Date Exercisable +-------+--------+ |Benefi- |ity: |In- |
| |Exercise| | |Securities |and Expiration Date | |Amount | |cially |Direct |direct |
| |Price of|Transac- |Transac- |Acquired(A)|(Month/Day/Year) | |or | |Owned |(D) or |Bene- |
|Title of |Deriv- |tion Date |tion Code|Disposed(D)+----------+----------+ |Number |Price of |at End |In- |ficial |
|Derivative |ative |(Month/ +------+--+-----+-----+Date Exer-|Expira- | |of |Derivative|of |direct |Owner- |
|Security |Security|Day/Year) |Code |V |(A) |(D) |cisable |tion Date |Title |Shares |Security |Month |(I) |ship |
+-------------+--------+----------+------+--+-----+-----+----------+----------+-------+--------+----------+--------+-------+-------+
<S> <C> <C> <C> <C><C> <C> <C> <C> <C> <C> <C> <C> <C> <C>
Stock Options $6.25 04/04/2000 M 10000 09/11/1999 03/11/2009 Common 10000 $6.250000 D
(Right to buy) Stock
Stock Options $6.25 04/10/2000 M 10000 09/11/1999 03/11/2009 Common 10000 $6.250000 45000 D
(Right to buy) Stock
</TABLE>
Explanation of Responses:
SIGNATURE OF REPORTING PERSON
/s/ Steve Dubin
DATE
05/12/2000
